EMG signals observed and the threshold in terms of voltage [17]
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"10507",leadTitle:null,fullTitle:"Current Topics in Chirality - From Chemistry to Biology",title:"Current Topics in Chirality",subtitle:"From Chemistry to Biology",reviewType:"peer-reviewed",abstract:"Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions.",isbn:"978-1-83968-954-3",printIsbn:"978-1-83968-953-6",pdfIsbn:"978-1-83968-955-0",doi:"10.5772/intechopen.92523",price:119,priceEur:129,priceUsd:155,slug:"current-topics-in-chirality-from-chemistry-to-biology",numberOfPages:196,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"692993cd6e2996714124df690df7c2e9",bookSignature:"Takashiro Akitsu",publishedDate:"September 1st 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10507.jpg",numberOfDownloads:2494,numberOfWosCitations:1,numberOfCrossrefCitations:6,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:8,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:15,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 30th 2020",dateEndSecondStepPublish:"October 28th 2020",dateEndThirdStepPublish:"December 27th 2020",dateEndFourthStepPublish:"March 17th 2021",dateEndFifthStepPublish:"May 16th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"147861",title:"Dr.",name:"Takashiro",middleName:null,surname:"Akitsu",slug:"takashiro-akitsu",fullName:"Takashiro Akitsu",profilePictureURL:"https://mts.intechopen.com/storage/users/147861/images/system/147861.jpg",biography:"Takashiro Akitsu, Ph.D., is now a professor in the Department of Chemistry, Faculty of Science Division II, Tokyo University of Science, Japan. Studying crystal and electronic structures of chiral copper complexes, he graduated from Osaka University and obtained his Ph.D. in Physical and Inorganic Chemistry in 2000. Dr. Akitsu studied at the Institute for Protein Research (metalloproteins), Keio University (photo and magnetic functional organic/inorganic hybrid compounds), and Stanford University (physical and bioinorganic chemistry) before moving to Tokyo University of Science. He has published 220 articles and book chapters. He has also served as an editorial board member and peer reviewer for many journals and was involved in the organizing committees for several international conferences.",institutionString:"Tokyo University of Science",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"6",institution:{name:"Tokyo University of Science",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"494",title:"Bioorganic Chemistry",slug:"organic-chemistry-bioorganic-chemistry"}],chapters:[{id:"76921",title:"Introductory Chapter: Chirality",doi:"10.5772/intechopen.98305",slug:"introductory-chapter-chirality",totalDownloads:124,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Takashiro Akitsu",downloadPdfUrl:"/chapter/pdf-download/76921",previewPdfUrl:"/chapter/pdf-preview/76921",authors:[{id:"147861",title:"Dr.",name:"Takashiro",surname:"Akitsu",slug:"takashiro-akitsu",fullName:"Takashiro Akitsu"}],corrections:null},{id:"76283",title:"Low Melting Mixture of L-(+)-Tartaric Acid and N,N′-Dimethyl Urea: A New Arrival in the Green Organic Synthesis",doi:"10.5772/intechopen.97392",slug:"low-melting-mixture-of-l-tartaric-acid-and-em-n-n-em-dimethyl-urea-a-new-arrival-in-the-green-organi",totalDownloads:269,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"After the first report of deep eutectic mixtures by the team of Abbott in 2003, the advent of green synthesis has been progressively changing the way synthetic chemistry is thought and also taught. Since then, a plethora of efforts worldwide have been taken to stretch the ideas of sustainable as well as environmentally benign approaches to do the crucial synthetic organic transformations under operationally simple yet effective conditions. Although, till date, several green synthetic strategies for examples ultrasound, microwaves, flow as well as grindstone chemistry etc., and green reaction media (e.g. ionic liquid, water, scCO2, and so forth) have successfully been invented. But a low melting mixture of L-(+)-tartaric acid (TA) and N,N′-dimethylurea (DMU), usually plays a double and/or triple role (solvent, catalyst, and/or reagent), though still infancy but enjoys several eye-catching properties like biodegradability, recyclability, non-toxicity, good thermal stability, tunable physiochemical properties, low vapor pressure as well as reasonable prices in addition to the easy preparation with wide functional groups tolerance. To this context, keeping the importance of this novel low melting mixture in mind, we intended to reveal the advancements taken place in this wonderful area of research since its first report by the Köenig’s group in 2011 to till date. In this particular chapter, firstly we would disclose the importance of the green synthesis followed by a brief description of deep-eutectic solvents (DESs) particularly emphasizing on the role of L-(+)-TA and DMU from modern synthetic chemistry perspective.",signatures:"Rashid Ali",downloadPdfUrl:"/chapter/pdf-download/76283",previewPdfUrl:"/chapter/pdf-preview/76283",authors:[{id:"346341",title:"Dr.",name:"Rashid",surname:"Ali",slug:"rashid-ali",fullName:"Rashid Ali"}],corrections:null},{id:"76467",title:"Gold Catalyzed Asymmetric Transformations",doi:"10.5772/intechopen.97519",slug:"gold-catalyzed-asymmetric-transformations",totalDownloads:260,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In this chapter, the strategies developed to attain asymmetric reactions with gold are disclosed. Because of its preferred linear arrangement, to induce asymmetry, gold(I) needs to fulfill one of the following requirements: a) the use of bulky chiral ligands, that create a chiral pocket around the active site, b) the coordination to bifunctional ligands capable to establish secondary interactions with substrates, or c) tight ion pairing with chiral counteranions. On the other hand, gold(III) profits of a square-planar coordination mode, which approaches chiral ligands to substrates. However, its tendency to be reduced leads to difficulties for its applications in catalytic asymmetric transformations. Pioneering works using cyclometaled structures, have found the balance between stability and activity, showing its potential in asymmetric transformations.",signatures:"Susana Porcel García",downloadPdfUrl:"/chapter/pdf-download/76467",previewPdfUrl:"/chapter/pdf-preview/76467",authors:[{id:"337879",title:"Dr.",name:"Susana",surname:"Porcel-García",slug:"susana-porcel-garcia",fullName:"Susana Porcel-García"}],corrections:null},{id:"75126",title:"Chiral Alkaloid Analysis",doi:"10.5772/intechopen.96009",slug:"chiral-alkaloid-analysis",totalDownloads:325,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Alkaloids are distributed in plant kingdom and play important role in protection, germination as well as plant growth stimulants. Most of them are chiral compounds and are clinically administered as the racemic mixture, even though its enantiomers have been known to exert different pharmacological activity. Liquid chromatography using chiral stationary phases (CSP) proved to be an essential tool with a wide range of applications, including analysis of the stereochemistry of natural compounds. This review gives an overview of chiral separation alkaloids that were used in theoretical studies and/or applications in recent years. It shows the possibilities of polysaccharide CSPs have now also been established as the first-choice of chiral phases for enantiomer separation.",signatures:"Ngoc Van Thi Nguyen, Kim Ngan Huynh Nguyen, Kien Trung Nguyen, Kyeong Ho Kim and Hassan Y. Aboul-Enein",downloadPdfUrl:"/chapter/pdf-download/75126",previewPdfUrl:"/chapter/pdf-preview/75126",authors:[{id:"336695",title:"Associate Prof.",name:"Ngoc-Van Thi",surname:"Nguyen",slug:"ngoc-van-thi-nguyen",fullName:"Ngoc-Van Thi Nguyen"},{id:"336699",title:"Prof.",name:"Kyeong Ho",surname:"Kim",slug:"kyeong-ho-kim",fullName:"Kyeong Ho Kim"},{id:"336700",title:"MSc.",name:"Kim-Ngan Huynh",surname:"Nguyen",slug:"kim-ngan-huynh-nguyen",fullName:"Kim-Ngan Huynh Nguyen"},{id:"345414",title:"Prof.",name:"Kien T.",surname:"Nguyen",slug:"kien-t.-nguyen",fullName:"Kien T. Nguyen"},{id:"345931",title:"Prof.",name:"Hassan Y.",surname:"Aboul-Enein",slug:"hassan-y.-aboul-enein",fullName:"Hassan Y. Aboul-Enein"}],corrections:null},{id:"75328",title:"Role of Click Chemistry in Organic Synthesis",doi:"10.5772/intechopen.96146",slug:"role-of-click-chemistry-in-organic-synthesis",totalDownloads:496,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Click chemistry involves highly efficient organic reactions of two or more highly functionalized chemical entities under eco-benign conditions for the synthesis of different heterocycles. Several organic reactions such as nucleophilic ring-opening reactions, cyclo-additions, nucleophilic addition reactions, thiol-ene reactions, Diels Alder reactions, etc. are included in click reactions. These reactions have very important features i.e. high functional group tolerance, formation of a single product, high atom economy, high yielding, no need for column purification, etc. It also possesses several applications in drug discovery, supramolecular chemistry, material science, nanotechnology, etc. Being highly significant and valuable, we have elaborated on several aspects of click reactions in organic synthesis in this chapter. Recent advancements in the field of organic synthesis using click chemistry approach have been deliberated by citing last five years articles.",signatures:"Ayushi Sethiya, Nusrat Sahiba and Shikha Agarwal",downloadPdfUrl:"/chapter/pdf-download/75328",previewPdfUrl:"/chapter/pdf-preview/75328",authors:[{id:"337057",title:"Assistant Prof.",name:"Shikha",surname:"Agarwal",slug:"shikha-agarwal",fullName:"Shikha Agarwal"},{id:"345237",title:"Ms.",name:"Ayushi",surname:"Sethiya",slug:"ayushi-sethiya",fullName:"Ayushi Sethiya"},{id:"345238",title:"Ms.",name:"Nusrat",surname:"Sahiba",slug:"nusrat-sahiba",fullName:"Nusrat Sahiba"}],corrections:null},{id:"74989",title:"Anion-π Catalysis: A Novel Supramolecular Approach for Chemical and Biological Transformations",doi:"10.5772/intechopen.95824",slug:"anion-catalysis-a-novel-supramolecular-approach-for-chemical-and-biological-transformations",totalDownloads:254,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Catalysts by virtue of lowering the activation barrier helps in the completion of a chemical reaction in a lesser amount of time without being themselves consumed. Utilizing the diverse non-covalent interactions in the design and construction of catalysts, recently anion-π interactions were also introduced, giving rise to an emerging field of anion-π catalysis. In the newly constructed anion-π catalysts, significant lowering of activation energy occurs by virtue of anion-π interactions. Till now, several important reactions generating chiral centers have been carried out on the π-acidic surfaces of anion-π catalysts, thereby revealing the significance of anion-π catalysis in the domain of asymmetric synthesis. The motive of this chapter is to highlight the role of anion-π catalysis in asymmetric synthesis and we surely believe that it will offer new opportunities in supramolecular chemistry.",signatures:"Ishfaq Ahmad Rather and Rashid Ali",downloadPdfUrl:"/chapter/pdf-download/74989",previewPdfUrl:"/chapter/pdf-preview/74989",authors:[{id:"334623",title:"Dr.",name:"Rashid",surname:"Ali",slug:"rashid-ali",fullName:"Rashid Ali"},{id:"334663",title:"Mr.",name:"Ishfaq Ahmad",surname:"Rather",slug:"ishfaq-ahmad-rather",fullName:"Ishfaq Ahmad Rather"}],corrections:null},{id:"75903",title:"Chiroptical Polymer Functionalized by Chiral Nanofibrillar Network",doi:"10.5772/intechopen.96853",slug:"chiroptical-polymer-functionalized-by-chiral-nanofibrillar-network",totalDownloads:242,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Chirality is one of the basic factors that influence a wide range of activities from chemical synthesis to tissue construction in life phenomena. Recently, researchers have attempted to use chirality as an optical signal. In animals, it is used to transmit information to insects and crustaceans, and it has also been confirmed that it promotes growth in plants. This chapter presents a new organic system that produces a chiral optical signal, that is, circularly polarized luminescence (CPL), which has been attracting attention in recent years. In particular, the chapter is focused on the generating CPL through chirality induction with the chiral self-assembling phenomenon and explaining its application as an optical film.",signatures:"Hirotaka Ihara, Makoto Takafuji and Yutaka Kuwahara",downloadPdfUrl:"/chapter/pdf-download/75903",previewPdfUrl:"/chapter/pdf-preview/75903",authors:[{id:"52605",title:"Prof.",name:"Makoto",surname:"Takafuji",slug:"makoto-takafuji",fullName:"Makoto Takafuji"},{id:"299189",title:"Prof.",name:"Hirotaka",surname:"Ihara",slug:"hirotaka-ihara",fullName:"Hirotaka Ihara"},{id:"340695",title:"Dr.",name:"Yutaka",surname:"Kuwahara",slug:"yutaka-kuwahara",fullName:"Yutaka Kuwahara"}],corrections:null},{id:"77627",title:"Chirality in Anticancer Agents",doi:"10.5772/intechopen.98977",slug:"chirality-in-anticancer-agents",totalDownloads:194,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Many drugs are chiral and their therapeutic activity depends on specific recognition of chiral biomolecules. The biological activity of enantiomers can also differ drastically in terms of toxicity and pharmacokinetics. Chiral natural biological molecules, such as nucleic acids, enzymes are targeted molecules for the development of anticancer drugs. The interest in chiral agents is logically a result of the different interaction with biomolecules leading in the end consequence to improve anticancer activity and maybe to less undesirable effects. This review outlines the effects of chirality on the efficiency of anticancer metal-based agents and potential organic drugs. A variety of up-to-date examples of structurally diverse chiral agents exhibiting different mechanisms in their antitumor activity is presented.",signatures:"Jindra Valentová and Lucia Lintnerová",downloadPdfUrl:"/chapter/pdf-download/77627",previewPdfUrl:"/chapter/pdf-preview/77627",authors:[{id:"337877",title:"Associate Prof.",name:"Jindra",surname:"Valentova",slug:"jindra-valentova",fullName:"Jindra Valentova"},{id:"421770",title:"Dr.",name:"Lucia",surname:"Lintnerová",slug:"lucia-lintnerova",fullName:"Lucia Lintnerová"}],corrections:null},{id:"75525",title:"Mirror Symmetry of Life",doi:"10.5772/intechopen.96507",slug:"mirror-symmetry-of-life",totalDownloads:330,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Functioning in the Earth gravity field imposes on living organisms a necessity to read directions. The characteristic feature of their bodies, regardless unicellular or multicellular, is axial symmetry. The development of body plan orchestrated by spatiotemporal changes in gene expression patterns is based on formation of the vertical and radial axes. Especially for immobile plants, anchored to the substrate, vertical axis is primary and most important. But also in animals the primary is the axis, which defines the anterior and posterior pole of the embryo. There are many little known chiral processes and structures that are left- or right oriented with respect to this axis. Recent developments indicate the role of intrinsic cell chirality that determines the direction of developmental chiral processes in living organisms. The still enigmatic events in cambia of trees and handedness of phyllotaxis as well as plant living crystals are in focus of the chapter.",signatures:"Beata Zagórska-Marek",downloadPdfUrl:"/chapter/pdf-download/75525",previewPdfUrl:"/chapter/pdf-preview/75525",authors:[{id:"336914",title:"Prof.",name:"Beata",surname:"Zagórska-Marek",slug:"beata-zagorska-marek",fullName:"Beata Zagórska-Marek"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5891",title:"Descriptive Inorganic Chemistry Researches of Metal Compounds",subtitle:null,isOpenForSubmission:!1,hash:"7201c7d0481358aa6aabe036eb9ff095",slug:"descriptive-inorganic-chemistry-researches-of-metal-compounds",bookSignature:"Takashiro Akitsu",coverURL:"https://cdn.intechopen.com/books/images_new/5891.jpg",editedByType:"Edited by",editors:[{id:"147861",title:"Dr.",name:"Takashiro",surname:"Akitsu",slug:"takashiro-akitsu",fullName:"Takashiro Akitsu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6190",title:"Symmetry (Group Theory) and Mathematical Treatment in Chemistry",subtitle:null,isOpenForSubmission:!1,hash:"3e429d96a01f4a95d3918d671f776dfc",slug:"symmetry-group-theory-and-mathematical-treatment-in-chemistry",bookSignature:"Takashiro Akitsu",coverURL:"https://cdn.intechopen.com/books/images_new/6190.jpg",editedByType:"Edited by",editors:[{id:"147861",title:"Dr.",name:"Takashiro",surname:"Akitsu",slug:"takashiro-akitsu",fullName:"Takashiro Akitsu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7549",title:"Basic Concepts Viewed from Frontier in Inorganic Coordination Chemistry",subtitle:null,isOpenForSubmission:!1,hash:"7bbd9beaeefecb9ec112a0a09432d241",slug:"basic-concepts-viewed-from-frontier-in-inorganic-coordination-chemistry",bookSignature:"Takashiro Akitsu",coverURL:"https://cdn.intechopen.com/books/images_new/7549.jpg",editedByType:"Edited by",editors:[{id:"147861",title:"Dr.",name:"Takashiro",surname:"Akitsu",slug:"takashiro-akitsu",fullName:"Takashiro Akitsu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8370",title:"Crystallography",subtitle:null,isOpenForSubmission:!1,hash:"d9e4456913ce86a573bc759d78238203",slug:"crystallography",bookSignature:"Takashiro Akitsu",coverURL:"https://cdn.intechopen.com/books/images_new/8370.jpg",editedByType:"Edited by",editors:[{id:"147861",title:"Dr.",name:"Takashiro",surname:"Akitsu",slug:"takashiro-akitsu",fullName:"Takashiro Akitsu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8346",title:"Chirality from Molecular Electronic States",subtitle:null,isOpenForSubmission:!1,hash:"2c8c9c50832625da3dc4cee759352246",slug:"chirality-from-molecular-electronic-states",bookSignature:"Takashiro Akitsu",coverURL:"https://cdn.intechopen.com/books/images_new/8346.jpg",editedByType:"Edited by",editors:[{id:"147861",title:"Dr.",name:"Takashiro",surname:"Akitsu",slug:"takashiro-akitsu",fullName:"Takashiro Akitsu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2326",title:"Cellulose",subtitle:"Fundamental Aspects",isOpenForSubmission:!1,hash:"de85a5810169999b1c069d863593e56a",slug:"cellulose-fundamental-aspects",bookSignature:"Theo van de Ven and Louis Godbout",coverURL:"https://cdn.intechopen.com/books/images_new/2326.jpg",editedByType:"Edited by",editors:[{id:"130492",title:"Dr.",name:"Theo G.M.",surname:"Van De Ven",slug:"theo-g.m.-van-de-ven",fullName:"Theo G.M. 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The field of electromyography is studied in Biomedical Engineering. And prosthesis using electromyography is achieved under Biomechatronics [1]. The electric signal produced during muscle activation, known as the myoelectric signal, is produced from small electrical currents generated by the exchange of ions across the muscle membranes and detected with the help of electrodes. Electromyography is used to evaluate and record the electrical activity produced by muscles of a human body. The instrument from which we obtain the EMG signal is known as electromyograph and the resultant record obtained is known as electromyogram [2].
The human body is a wonder of nature. The functioning of human body is an intriguing and fascinating activity. Motion of the human body is a perfect integration of the brain, nervous system and muscles. It is altogether a well-organized effort of the brain with 28 major muscles to control the trunk and limb joints to produce forces needed to counter gravity and propel the body forward with minimum amount of energy expenditure [3]. The movement of the human body is possible through muscles in coordination with the brain. Whenever the muscles of the body are to be recruited for a certain activity, the brain sends excitation signals through the Central Nervous System (CNS). Muscles are innervated in groups called ‘Motor Units’. A motor unit is the junction point where the motor neuron and the muscle fibers meet. A depiction of the Motor Unit is given in Figure 1. When the motor unit is activated, it produces a ‘Motor Unit Action Potential’ (MUAP) [4]. The activation from the Central Nervous System is repeated continuously for as long as the muscle is required to generate force. This continued activation produces motor unit action potential trains. The trains from concurrently active motor units superimpose to produce the resultant EMG signal. A group of muscles are involved in a certain movement of the human body. The number of muscles recruited depends upon the activity in which the body is involved. E.g. in lifting a small weight such as a tiny pebble, fewer amount of muscles will be involved as compared to lifting a heavy mass like a 6 kg weight, where the muscles employed will be greater. In technical terms, whenever it is required to generate greater force, the excitation from the Central Nervous System increases, more motor units are activated and the firing rate of all the motor units increase resulting in high EMG signal amplitudes [4,5].
A Motor Unit consists of one motor neuron and all the muscle fibers it stimulates [
Electromyography enables us to generate force, create movements and allow us to do countless other functions through which we can interact with the world around us. The electromyograph is a bioelectric signal which has, over the years, developed a vast range of applications. Clinically, electromyography is being used as diagnostic tool for neurological disorders. It is frequently being used for assessment of patients with neuromuscular diseases, low back pain and disorders of motor control [7]. Other than physiological and biomechanical research, EMG has been developed as an evaluation tool in applied research, physiotherapy, rehabilitation, sports medicine and training, biofeedback and ergonomics research.
In the recent past, EMG has also found its use in rehabilitation of patients with amputations in the form of robotic prosthesis. EMG proves to be a valuable tool as it provides a natural way of sensing and classifying different movements of the body. A multi-degree of freedom robotic mechanism can effectively imitate the motion of the human limb. Recent advances in electronics and microcontroller technology have allowed improved control options for robotic mechanisms. One of the most vital advantages of microprocessor technology in robotic prosthetics is the advanced EMG filtering algorithms. Nowadays, control options are even available to those who were not at one time qualified for such prosthetic management.
This chapter will discuss in detail, the effective use of surface electromyography (SEMG) as a tool for achieving robotic prosthesis. An elaborate account of SEMG electrode types, signal acquisition technique, electronics circuit design considerations and the control procedure to drive electric motors in a robotic mechanism is provided in this chapter.
The bioelectrical activity inside the muscle of a human body is detected with the help of EMG electrodes. There are two main types of EMG electrodes: surface (or skin electrodes) and inserted electrodes. Inserted electrodes have further two types: needle and fine wire electrodes. The three electrodes (needle, fine wire and surface) are explained as follows. Among these three electrodes, surface EMG electrodes will be specifically discussed in detail as it pertains to the topic of this chapter.
Needle electrodes are widely used in clinical procedures in neuromuscular evaluations. The tip of the needle electrode is bare and used as a detection surface. It contains an insulated wire in the cannula. The signal quality from the needle electrodes is comparatively improved from other available types. Needle electrodes have two main advantages. One is that its relatively small pickup area enables the electrode to detect individual MUAPs during relatively low force contractions. The other is that the electrodes may be conveniently repositioned within the muscle (after insertion) so that new tissue territories may be explored [5]. A needle electrode is shown in Figure 2.
A Needle EMG Electrode [
Wire electrodes are made from any small diameter, highly non-oxidizing, stiff wire with insulation. Alloys of platinum, silver, nickel, and chromium are typically used. Wire electrodes are extremely fine, they are easily implanted and withdrawn from skeletal muscles, and they are generally less painful than needle electrodes whose cannula remains inserted in the muscle throughout the duration of the test [5]. A fine wire electrode is shown in Figure 3.
Fine Wire EMG Electrode
Surface EMG electrodes provide a non-invasive technique for measurement and detection of EMG signal. The theory behind these electrodes is that they form a chemical equilibrium between the detecting surface and the skin of the body through electrolytic conduction, so that current can flow into the electrode.
These electrodes are simple and very easy to implement. Application of needle and fine wire electrodes require strict medical supervision and certification. Surface EMG electrodes require no such formalities. Surface EMG electrodes have found their use in motor behavior studies, neuromuscular recordings, sports medical evaluations [9] and for subjects who object to needle insertions such as children. Apart from all this, surface EMG is being increasingly used to detect muscle activity in order to control device extensions to achieve prosthesis for physically disabled and amputated population.
Surface EMG has some limitations as well. Since these electrodes are applied on the skin, hence, they are generally used for superficial muscles only. Crosstalk from other muscles is a major problem. Their position must be kept stable with the skin; otherwise, the signal is distorted.
There are two types of surface EMG electrodes: Gelled and Dry EMG electrodes [10].
2.3.1.1. Gelled EMG Electrodes
Gelled EMG electrodes contain a gelled electrolytic substance as an interface between skin and electrodes. Oxidation and reduction reactions take place at the metal electrode junction. Silver – silver chloride (Ag-AgCl) is the most common composite for the metallic part of gelled electrodes. The AgCl layer allows current from the muscle to pass more freely across the junction between the electrolyte and the electrode. This introduces less electrical noise into the measurement, as compared with equivalent metallic electrodes (e.g. Ag). Due to this fact, Ag-AgCl electrodes are used in over 80% of surface EMG applications [10].
Disposable gelled EMG electrodes are most common; however, reusable gelled electrodes are also available. Special skin preparations and precautions such as (hair removal, proper gel concentration, prevention of sweat accumulation etc.) are required for gelled electrodes in order to acquire the best possible signal. Gelled EMG electrodes are shown in Figure 4.
Gelled EMG Electrodes
2.3.1.2. Dry EMG electrodes
Dry EMG electrodes do not require a gel interface between skin and the detecting surface. Bar electrodes and array electrodes are examples of dry electrodes. These electrodes may contain more than one detecting surface. In many examples, an in-house pre-amplification circuitry may also be employed in these electrodes. A reusable bar electrode is shown in Figure 5. Dry electrodes are usually heavier (>20g) as compared to gelled electrodes (<1g). This increased inertial mass can cause problems for electrode fixation; therefore, a material for stability of the electrode with the skin is required [10].
A Reusable Bar Electrode (an Example of Dry EMG Electrode)
There are two categories of surface EMG electrodes [5]: Passive and Active EMG electrodes. They are briefly explained as follows:-
2.3.2.1. Passive EMG electrodes
These electrodes should be connected to an external amplification circuitry with the help of connecting wires for the proper acquisition of the EMG signal. Passive EMG electrodes can be disposable or reusable.
Electrodes shown in Figure 4 and Figure 5 both fall under passive surface EMG electrodes.
2.3.2.2. Active EMG electrodes
Active EMG electrodes contain a pre-amplifier attachment for surface electrodes. Needle and fine wire surface electrodes are also available. These electrodes usually fall under the dry surface EMG electrodes type. The in-house high impedance amplifier in these electrodes transfers the pre-amplified signal to the rest of the circuitry. Figure 6 shows an active EMG electrode.
The Delsys 2.1 Active EMG Electrode [
Surface EMG is relatively easy to use as compared to other EMG electrodes. This is the reason why it is being extensively used in the control of robotic mechanisms to achieve prosthesis. It is also widely used in latest EMG researches by engineers as no medical certification or expertise is required for its application. Its use in rehabilitation prosthesis is favorable as it does not cause any kind of discomfort to the subject on whom it is applied. Other kinds of EMG electrodes (needle and fine wire), when inserted into the skin of the subject, may effect a twitching sensation and cause him or her to make movements.
In order to get the best results from SEMG, it is really important to have a proper understanding of the muscles from which the EMG signal is being extracted. The placement on skin also requires adequate study and requires skin preparation beforehand as well.
The EMG electrodes, their types, sub-types and categories have already been explained in detail in the previous section. Since, our concern is only with Surface EMG (SEMG), hence, we will only deal with the placement and signal acquisition technique using surface EMG electrodes.
Skeletal muscle architecture is defined in terms of "the arrangement of muscle fibers relative to the axis of force generation." The skeletal muscle arrangement as well as their activity reveals striking organization at the macroscopic level. The functional properties of the skeletal muscle depend strongly on their architecture [12].
There are various kinds of muscle fiber arrangements, which are discussed as follows:-
Muscles with fibers that extend parallel to the muscle force-generating axis are termed
Muscles with fibers that are oriented at a single angle relative to the force generating axis are termed unipennate muscles. Example of unipennate muscle is Extensor Digitorum Longus.
The angle between the fiber and the force-generating axis generally varies from 0° to 30°. The muscles are oriented at more than one angle. Most muscles fall into this category and they are called as
The muscles which surround an opening so as to form a closed shape are known as circular muscles. Example of such kind of muscle is Orbicularis Oris (mouth muscle).
The muscles in which their fibers converge on the insertion to maximize force of contraction are known as
A detailed depiction of these muscle arrangements is provided in Figure 7.
Muscles and their Architecture [
Application of surface EMG electrodes requires proper skin preparation beforehand. In order to obtain a good quality EMG signal, the skin’s impedance must be considerably reduced. For this purpose, the dead cells on the skin e.g. hair must be completely removed from the location where the EMG electrodes are to be placed. It is advisable to use an abrasive gel to reduce the dry layer of the skin [9]. There should be no moisture on the skin. The skin should be cleaned with alcohol in order to eliminate any wetness or sweat on the skin.
Skin Preparation prior to application of EMG electrodes
The application of EMG electrodes requires adequate know how of the skeletal muscles. The EMG electrode placement will be discussed in detail under this section.
In most cases, two detecting surfaces (or EMG electrodes) are placed on the skin in bipolar configuration [14, 15]. In order to acquire the best possible signal, the EMG electrode should be placed at a proper location and its orientation across the muscle is important. The surface EMG electrodes should be placed between the motor unit and the tendinous insertion of the muscle, along the longitudinal midline of the muscle [15]. The distance between the center of the electrodes or detecting surfaces should only be 1-2 cm. The longitudinal axis of the electrodes (which passes through both detecting surfaces) should be parallel to the length of the muscle fibers.
As mentioned previously, the EMG detecting surfaces should be placed in between the motor unit and the tendon insertion of the muscle. Detecting surfaces placed on the belly of the muscle has proved to be a more than acceptable location. Here, the target muscle fiber density is the highest [15]. Figure 9 shows the proper EMG electrode placement. When the electrodes are arranged in this way, the detecting surfaces intersect most of the same muscle fibers, and as a result, an improved superimposed signal is observed.
The electrodes should not be placed elsewhere. In the past, a misconception prevailed that the EMG detecting surfaces should be placed on the motor unit. But, as a matter of fact, the electrode location on the motor point serves as the worst location for signal detection [15]. Similarly, the electrodes should neither be placed at or near the tendon nor at the edge of the muscle. The muscle fibers become thinner and smaller in number when they approach the tendon of the muscle resulting in a weak EMG signal, proving the fact that electrode placement near the tendon is not feasible. If the electrode is placed at the edge of the muscle, the chances of crosstalk from other muscles will considerably increase, and the resultant signal will be disturbed by those of other muscles [15].
The ideal position of the electrode (two detecting surfaces) is between the innervation zone (or motor unit) and the tendinous insertion (or belly of the muscle) [
Before we move on to the signal acquisition phase, it is very important to get acquainted with the EMG signal and the various concerns and factors affecting the qualitative properties of the signal.
The EMG signal’s amplitude lies in between 1-10 mV, making it a considerably weak signal. The signal lies in the frequency range from 0-500 Hz and most dominant in between 50-150 Hz [15].
The EMG signal is highly influenced by noise [16], as shown in Figure 10. The characteristics of electrical noise can be caused from various sources. Ambient noise can be caused by electromagnetic radiation sources e.g. radio transmission devices, fluorescent lights and power line interference from electrical wires. These interferences are almost impossible to avoid from external means. This particular noise exists in the frequency range of 50-60 Hz. Noise can also be generated from motion artifact. The two main sources of this noise are instability of electrode skin interface and movement of the electrode cable and lies mostly in the range of 0-20 Hz. It can be eliminated by proper set of EMG equipment and circuitry. The maximum fidelity of the signal is determined by the acquired EMG signal-to-noise ratio [5, 14].
The signal from the EMG detecting surfaces is gathered with respect to a reference. An EMG reference electrode acts as a ground for this signal. It should be placed far from the EMG detecting surfaces, on an electrically neutral tissue [15].
EMG Spectrum and noise influence on this spectrum [
The EMG electrode placement has been elaborately explained under the previous heading. So, after properly understanding the target muscle profile, preparing the skin and positioning the EMG detecting surfaces, comes the EMG signal acquisition step.
EMG signal is acquired through differential amplification technique. The differential amplifier should have high input impedance and very low output impedance. Ideally, a differential amplifier has infinite input and zero output impedance [17].
Differential amplification is achieved with the help of an instrumentation amplifier for high input impedance. A classic three amplifier instrumentation amplifier is shown in Figure 11.
The instrumentation amplifier carries out differential amplification by subtracting the voltages V1 and V2. This way, the noise signal which is common at V1 and V2 (electrode inputs) e.g. power line interference etc. are eliminated. The tendency of a differential amplification to reject signals common to both inputs is determined by common mode rejection ratio (CMRR). A CMRR of 90 dB is enough for elimination of common signals for instrumentation amplifiers, but latest technology, even though expensive, provides us with a CMRR of 120 dB. But there are reasons for not pushing the CMRR to the limit, as the electrical noise detected by the electrodes may not be in phase [15]. The gain for the instrumentation amplifier can be set using a single resistor (Rgain). The gain equation and output equation of the instrumentation amplifier is given in Eq. 1 and 2.
A small gain of 5 or 6 is recommended for signal acquisition. Extensive amplification will be carried out in further steps. The placement of the EMG detecting surfaces can be done through three different configurations: monopolar, bipolar and multipolar.
A Three Amplifier Instrumentation Amplifier
The monopolar configuration is implemented using only a single electrode on the skin with respect to a reference electrode as shown in Figure 12. This method is used because of its simplicity, but is strictly not recommended as it detects all the electrical signals in the vicinity of the detecting surface [5, 14].
Monopolar signal acquisition technique
Bipolar configuration is used to acquire EMG signal using two EMG detecting surfaces with the help of a reference electrode. The signals from the two EMG surfaces are connected to a differential amplifier. The two detecting surfaces are placed only 1-2 cm from each other. The differential amplifier suppresses the common noise signals to both inputs and then amplifies the difference [5, 14]. The limitations of the monopolar configuration are catered for by this configuration. This is the most commonly used electrode configuration. The bipolar EMG electrode configuration is shown is Figure 13.
Bipolar Configuration
This configuration uses more than two detecting surfaces to acquire the EMG signal with the help of a reference electrode. This configuration further reduces crosstalk and noise concerns [14]. A much more enhanced EMG signal is acquired from this configuration. The signals from three or more EMG detecting surfaces, placed 1-2 cm from each other, are passed through more than two stages of differential amplification. For example if three detecting surfaces are used then double differential technique is employed.
This configuration is used in comprehensive researches carried out to study EMG muscle fiber orientation, conduction velocity and motor point localization.
This section will discuss the electrical design considerations in order to synthesize the best possible EMG signal from the muscles of the human body in thorough detail. The basic circuitry for signal acquisition or preamplification circuitry is explained in due detail in the previous section. In this section we will discuss the circuitry implemented after the preamplification stage.
As discussed earlier, there are many concerns regarding the proper detection of the EMG signal. Once the electrode is properly placed and the signal is extracted, noise plays a major role in hampering the recording of the EMG signal. For this purpose, the signal has to be properly filtered, even after differential amplification [18, 19].
The noise frequencies contaminating the raw EMG signal can be high as well as low. Low frequency noise can be caused from amplifier DC offsets, sensor drift on skin and temperature fluctuations and can be removed using a high pass filter. High frequency noise can be caused from nerve conduction and high frequency interference from radio broadcasts, computers, cellular phones etc. and can be deleted using a low pass filter.
In order to remove these high and low frequencies, high pass and low pass bio-filters will be discussed in adequate detail in this section.
A high pass filter is used to remove low frequency component from a particular electrical signal. A term ‘cut-off frequency’, denoted by ‘
A high pass filter response
A high pass filter can be developed by using a resistor and a capacitor. This circuit will then be known as a CR circuit [20]. This circuit is a first order high pass filter. It is the simplest high pass filter possible. The high pass filtered signal is gathered across the resistor. The filter is shown in Figure 15.
The cut-off frequency of the high pass filter is given in Eq. 3.
A second order high pass filter can also be designed. An effective design can employ an active electronic component [20]. The design uses two first order filters in series and is facilitated by an operational amplifier. The circuit is given Figure 16.
For this circuit, if R1 = R2; C1 = C2 then
R3 and R4 are optional and are required for separate gain settings as:-
Using a 2nd order filter is recommended as they provide a roll-off of 40 dB/dec as compared to 20 dB/dec provided by 1st order filters [18]. The use of active components can isolate the filter from the rest of the circuitry.
First order high pass filter
A 2nd Order High Pass Filter
The concept of low pass filters is entirely opposite to that of high pass filters. In these filters, the frequencies less than the cut-off frequency are transmitted and above that are removed [18]. A low pass filter response is shown in Figure 17.
The simplest low pass filter can be designed with the help of a resistor and a capacitor called as a 1st order RC circuit [20]. The low pass filtered signal is detected across the capacitor. The 1st order low pass filter circuit is shown in Figure 18.
Low Pass Filter Response
Order Low Pass Filter
The cut-off frequency equation for the circuit in Figure 18 is the same as that of Eq. 3.
A 2nd order low pass filter can be more effective as compared to a 1st order one. It can be designed by cascading two 1st order filters attached to an operational amplifier. The circuit is given in Figure 19.
Order Low Pass Filter
For R1 = R2 and C1 = C2, the cut-off frequency of the circuit in Figure 19 is the same as that of Eq. 4. R3 and R4 are optional as they are required for separate gain settings as given in Eq. 5. A 2nd order low pass filter is again recommended as compared to a 1st order one for the same reasons mentioned for a 2nd order high pass filter.
As mentioned previously, for the transmission of pure EMG, the high and low frequency noise should be deleted. For this purpose, only a specific band of frequency should be carried forward [20]. This can be made possible with the help of a band pass filter. A band pass filter response is shown in Figure 20.
Band Pass Filter Response
The frequency region where the response of the EMG signal is ‘1’ is called the ‘passband’ and in the case of band pass filter, it is between
A band pass filter can be designed by connecting a low pass and a high pass filter in series. By selecting proper values of R and C, we can develop a band pass filter which can carry forward the most effective component of the EMG signal. It is recommended that for EMG,
After the signal has been filtered properly and a suitable band of EMG frequency is obtained, the next stage is amplification. The EMG signal obtained has to be powered up to a suitable level. The amplification of the EMG signal can be easily carried out with the help of a non-inverting amplifier, shown in Figure 21.
The gain of the amplifier is provided in the figure as ‘Av’. The non-inverting amplifier is only used when the signal is being received from a single wire referenced to ground. Amplification can be done in stages in order to cater for chip requirements, by cascading them in series.
The EMG signal, as mentioned before, is very weak i.e. only 1-10 mV. For certain muscles, for which the signal response is very strong e.g. Biceps Brachii, a gain of 500-1000 can be enough. But for muscles, whose EMG response is weak e.g. Flexor Palmaris Longus (ring finger muscle), the gain settings should be very high i.e. 10000.
The proper gain setting solely depends upon the signal response observed from the subject’s target muscle. It is to be noted that every subject gives a separate signal response. Some subjects will give weak responses as compared to others. So, in that case, appropriate gain value should be set once the subject’s EMG signal response is properly observed.
A Non-Inverting Amplifier
In order to successfully achieve robotic prosthesis, an effective control technique is very important in order to drive the electric motors in the mechanism. With the advent of modern microcontroller technology, the control options available today have never been so effective.
For implementing the desired control to the motors, the amplified EMG signal in analog form has to be converted into digital format. After this, the motors are driven with the help of a microcontroller through the thresholding technique. These techniques will be discussed in detail in this section.
The digitization process of the analog signal is carried out with an Analog to Digital Converter (ADC). Nowadays, the ADC has become a common component of modern electronic devices. Their use has become highly varied and widespread. Before using the ADC, its specifications, advantages and limitations have to be analyzed in order to select the most appropriate one for the application. In the same way, important considerations have to be taken into account while converting EMG signals into digital format.
Control of the motor will be developed after the EMG signal is converted into digital format. A particular ADC has a specific range of conversion i.e. there are maximum and minimum levels defined for an ADC over which it can operate. An ADC can convert the analog signal over a certain number of bits. The number of bits which an ADC can convert is known as its “quantization scheme”. If an ADC has a defined range and a quantization scheme of
While converting an EMG signal into digital format, three specifications should be taken into account. 1) Quantization, 2) Range of conversion and 3) Sampling rate [21].
The number of bits, which an analog signal can be converted into digital format by an ADC, is known as quantization. The maximum amount of voltage an ADC can convert into digital quantized bits defines the range of an ADC. The sampling rate means the number of samples an ADC can convert in one second.
After the EMG signal has been amplified up to a suitable level, the range of an ADC should be selected so that it can comprehend a particular voltage level. The number of quantization bits is important, as they determine the resolution of the ADC. The more the number of quantization bits, the less will be resolution of the ADC; the more it will help in control purposes. The ADC sampling rate is also a key consideration. It should be kept as large as possible so that the data loss of EMG is kept at a minimum [21].
ADCs are now available as a peripheral with microcontroller chips and can give sampling rates greater than 1000 kSPS and quantization schemes of more than 24 bits.
The control of robotic prosthesis is provided through the thresholding technique [21]. Once the signal is received in digital format, taking all necessary considerations as described before, a suitable threshold is applied to that particular quantized digital signal.
Before applying the threshold, the digital quantized signal is to be observed properly. A threshold value should then set be accordingly. It is recommended to set the threshold value to a point which is less than half the digital quantized output of the EMG signal. When the digital signal exceeds this threshold, the microcontroller should set an output pin to ’1’ and ‘0’ otherwise [21]. E.g. if the maximum value of the digital quantized signal is 750 (decimal value) then we can set a threshold of 275. This signal is forwarded to an H-bridge or a motor driver in order to drive the respective electric motors of a robotic mechanism.
The motor driver should be designed or selected according to our requirements of electric motor. Usually a motor driver which can drive a 12V motor and handle up to 4A current can adequately meet requirements for a robotic arm.
A useful way of acquiring EMG signals and motor drive has been explained in this chapter. Modern microelectronics and controllers have enabled us to develop efficient control of prosthetic robotic mechanisms. To summarize the discussions made earlier, Figure 22 shows a block diagram depicting all the necessary steps required to achieve successful prosthesis.
Block diagram indicating all steps for driving a robotic mechanism
As an example, we discuss the control of a robotic hand. There are two primary motions of the human hand, flexing and extending. For flexion, electrode should be placed on Flexor Digitorum Profundus and for extension; the electrode should be placed on Extensor Digitorum Communis [21]. As both muscles exhibit different signal patterns, therefore, a multi-channel input scheme should be employed, so that both signals are gathered independently. Both signals should be observed carefully and a suitable threshold should be set after filtering and amplification. The same procedure is to be followed in order to develop control of all the fingers of the robotic hand i.e. by placing EMG electrodes on specific muscles which control them, allowing us to classify different motions of the hand [22].
The signal observed from a subject with a moderate built is shown in Table 1. The amplification set for the detected EMG signals from the subject was 10,000. Table 1 provides the EMG signal response from each of the subject’s fingers after amplification and threshold set for their control [21].
Size is a very important factor while designing an electronics circuit. A circuit occupying minimum space will be most appropriate in application. A size effective circuit will be easy to place and handle in a robotic mechanism. Advances in biomedical instrumentation have brought fruitful gains to robotic prosthetic technology. The ADS1298 is a 64 pin IC with 8 differential inputs with programmable gain amplifiers (PGAs) and a 24 bit ADC. The PGAs can provide a maximum gain of 12 but the 24 bit ADC quantization scheme is enough to process the EMG signal [23]. With all necessary peripherals attached to a single IC, the size of the whole circuitry can be reduced up to 95%.
Latest robotic researches have enabled us to design and create multi-degree of freedom robotic mechanisms [24]. A good mechanical design and apparatus is essential for efficient robotic prosthesis. Newer electronic components and materials have made robotic prosthesis more functional and adaptable. When we talk about materials, the perfect one should be lighter, durable, adjustable and comfortable for the user. Nowadays, carbon fiber frames are being employed as a solution to this matter. An example of a carbon fiber limb is the state of the art Ottoblock C-Leg. The C-Leg has a built in computer which analyzes data from various sensors and actuates the knee using a hydraulic cylinder.
When a human uses a robot, he desires to use his natural limb movements to control the mechanism. In order to achieve this, EMG provides the perfect assistance to allow a subject to make normal movements using a robotic apparatus, hence, efficient controllers and improved algorithms are essential for enhanced control of the device. Given the fact that EMG was introduced more than 30 years ago, the research community has a come a long way in coming up with innovative techniques, hardware solutions and advanced procedures to design, control and utilize these signals to produce resourceful prosthetic means to tackle disabilities and amputations effectively.
Threshold Set (V) | ||||
1 | Thumb (flexing) | 0.8 | 3.7 | 1.4 |
2 | Index (flexing) | 0.6 | 1.4 | 0.8 |
3 | Ring (flexing) | 0.2 | 2.5 | 0.7 |
4 | Pinkie (flexing) | 0.2 | 1 | 0.5 |
5 | Hand (flexing) | 0.2 | 5 | 1 |
6 | Hand (extending) | 0.15 | 4.5 | 0.8 |
EMG signals observed and the threshold in terms of voltage [17]
Scientists working on upper limb prosthesis define their goal in this field as to develop a ‘simultaneous, independent, and proportional control of multiple degrees of freedom with acceptable performance and near “normal” control complexity and response time’ [25]. The major challenges faced in prosthetics are: electromechanical implementation, use of EMG control signals and the interface between robotic and clinical communities [26]. Designing a robotic mechanism which is fully capable of integrating with human neuromuscular system is a tough proposition. The requirements can only be fulfilled if the apparatus is of light and flexible material with small but powerful actuators, size effective electronic components, sensors which can easily adapt with the skin and a long lasting battery life. Only then the machine will qualify to be used in everyday practical life [26].
The human hand has 20 degrees of freedom, and the body works in a unique variety of ways to tackle various hindrances placed in front of it. It is therefore, a great challenge to extract all of these motions from the body and utilize them in a resourceful way. Nowadays, two degree of freedom mechanisms are most common. To achieve further DOFs, sensors will be required to be placed at more sophisticated locations, which is a tough task.
The most important challenge of robotic prosthesis in rehabilitation is the feasibility of the mechanism. The apparatus should be comfortable, silent and aesthetically viable for the subject [26]. Our target should be the effective use of the robotic artificial limb on the physically disabled, not to waste our efforts in fruitless objects. Hence, for the reliability of the mechanism’s implementation on the amputated population, clinician’s approval should be made a part of the procedure.
Due to its practicality and noninvasiveness, SEMG proves to play a significant role in medical applications and rehabilitation prosthesis. However, the human machine interface will decide if the robotic mechanism will be used in everyday life application or not. It is very important to improve the Quality of Life (QOL) of elder and disabled population. It is believed that in the near future, “we will be able to replace entire limbs with prosthetics that can replicate one’s own biological functions precisely, casting natural outward appearance and requiring minimum upkeep” [26].
Robotic researchers and biomedical engineers have been trying to combine their techniques to make the perfect biomechatronic mechanism. However, in order to ensure that challenges are met and to create a more smart and intelligent machine, communication between clinicians, users and engineers should be established on a greater scale.
The study was carried out at College of Electrical and Mechanical Engineering (CEME), NUST in collaboration with Armed Forces Institute of Rehabilitation Medicine (AFIRM). The author is highly indebted to Brig. Dr. Javaid Iqbal and Dr. Umer Shahbaz Khan for their help in the study and CEME for providing necessary funds to make this research possible. Special thanks to all colleagues and people who have willingly helped out with their abilities.
Oral ulcerative lesions are defects in the oral epithelia, its underlying connective tissue or both. The oral mucosa is considered among one of the susceptible areas in the human body to painful ulceration [1, 2]. An oral ulcer is not a disease itself but rather a sign of a different underlying condition, therefore it is usually challenging to diagnose the accurate etiology [1]. It is important to identify the etiologic factor to provide a complete resolution to patients rather than constantly prescribing certain medicines to suppress the symptoms [3].
Regardless of the etiology of these lesions, oral ulcerative lesions may be categorized as minor, major or herpetiform ulcerations. Minor ulcerations are usually less than 1 cm in diameter, and they most commonly present on the labial or buccal mucosa or the ventral surface of the tongue. Less common locations include the dorsum of the tongue, hard palate or the gingiva [4, 5].
Ulcerations that measure more than 1 cm in diameter are referred to as major oral ulcerations and have a lower prevalence than minor ones. Among these three types, the least common type is the herpetiform ulceration, which unlike what its name suggests, is irrelevant to herpetic stomatitis since no vesicle formation is observed in advance [5]. These type of ulcerations are multiple and usually are much smaller in diameter (1–3 mm) [4].
Another helpful classification is based on the duration of these lesions, which may aid clinicians establish a more logical stepwise progression towards an accurate diagnosis. Accordingly, an oral ulcerative lesion is diagnosed as acute if it lasts for less than two weeks, chronic if it persists for more than two weeks or recurrent if it presents with a history ulcerative episode with intermittent periods of healing [1].
A short-lived oral ulcerative lesion which resolves in less than two weeks is considered as an acute oral ulcer and is commonly referred to as an “aphtha” [1, 2]. This word itself is attributed to Hippocrates which was used to describe disorders of the mouth in general back in his time (460–370 BC) [3]. In order to accurately diagnose and evaluate patients with acute ulcerative lesions, it is crucial that the physician is aware of the broad spectrum of possibilities that may cause these lesions. It is recommended to assess the history of the lesions first, meaning to question the patient regarding any periodic episodes, in order to exclude conditions which are characterized with recurrent oral ulcerations [2].
Clinically acute oral ulcers usually have an oval shape with an erythematous periphery due to the dilation of the blood vessels. Although commonly these are painful lesions, the pain is relatively weaker when the ulcer bed is layered with a yellowish fibro-membrane [2].
Most common acute oral ulcerations may be related to trauma (i.e., traumatic ulcers), chemotherapy (i.e. chemotherapy induced ulcers), necrotizing sialometaplasia, primary herpetic gingivostomatitis, herpes zoster infection, herpangina, hand-foot mouth disease, erythema multiforme, necrotizing ulcerative gingivitis, oral hypersensitivity reactions or plasma cell stomatitis [1, 6, 7].
Irritation fibroma of the right vestibular sulcus and an acute traumatic ulceration of the maxillary frenulum due to ill-fitting dentures.
Oral hypersensitivity reaction, three days after switching to a new brand of toothpaste.
Severe epithelial sloughing and erythema on a patient with plasma cell stomatitis.
Chronic ulcerative lesions have a slower onset than acute ulcers and last for more than two weeks. Several vesiculobullous entities, lupus erythematosus, tuberculosis, some mycoses, eosinophilic ulcers and oral cancer are among the most common conditions associated with chronic oral ulcerative lesions [6].
Wickham’s striae: The characteristic white, lace-like keratotic configurations seen in lichen planus.
Erosive lichen planus with an ulcerative area covered with a yellowish white pseudomembrane.
Typical “crater like lesion with rolled borders”-look on a malignant ulcerative lesion of the hard palate.
Cause-based treatment options are more beneficial than palliative management options. Therefore it is crucial for physicians to make a sound clinical examination and take a through patient history [3]. Biopsy should be considered if an ulcerative lesion with an unknown etiology shows no signs of healing after two weeks, or if the lesions is not responsive to a treatment aimed at a probable known etiology. Ulcers of less than 5 mm diameter are advised to undergo an excisional biopsy, whereas for larger ones an incisional biopsy is suggested [6].
The author declares no conflict of interest.
Supporting women in scientific research and encouraging more women to pursue careers in STEM fields has been an issue on the global agenda for many years. But there is still much to be done. And IntechOpen wants to help.
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\\n\\nPlus, we want this project to have an impact beyond scientific circles. We will publicize the research in the Women in Science program for a wider general audience through:
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\n\nWe aim to publish 100 books in our Women in Science program over the next three years. We are looking for books written, edited, or co-edited by women. Contributing chapters by men are welcome. As always, the quality of the research we publish is paramount.
\n\nAll project proposals go through a two-stage peer review process and are selected based on the following criteria:
\n\nPlus, we want this project to have an impact beyond scientific circles. We will publicize the research in the Women in Science program for a wider general audience through:
\n\nInterested? If you have an idea for an edited volume or a monograph, we’d love to hear from you! Contact Ana Pantar at book.idea@intechopen.com.
\n\n“My scientific path has given me the opportunity to work with colleagues all over Europe, including Germany, France, and Norway. Editing the book Graph Theory: Advanced Algorithms and Applications with IntechOpen emphasized for me the importance of providing valuable, Open Access literature to our scientific colleagues around the world. So I am highly enthusiastic about the Women in Science book collection, which will highlight the outstanding accomplishments of women scientists and encourage others to walk the challenging path to becoming a recognized scientist." Beril Sirmacek, TU Delft, The Netherlands
\n\nAdvantages of Publishing with IntechOpen
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This study is aimed to focus on proceeding of the most vital metabolic processes namely reserve mobilization, phytohormonal regulation, glyoxylate cycle and respiration process under either stressful or non-stressful conditions that may be led to suggest and conduct the more successful experimental improvements. Seed imbibition triggered the activation of various metabolic processes such as synthesis of hydrolytic enzymes which resulted in hydrolysis of reserve food into simple available form for embryo uptake. Abiotic stresses potentially affect seed germination and seedling establishment through various factors, such as a reduction in water availability, changes in the mobilization of stored reserves, hormonal balance alteration and affecting the structural organization of proteins. Recent strategies for improving seed quality involved classical genetic, molecular biology and invigoration treatments known as priming treatments. H2O2 accumulation and associated oxidative damages together with a decline in antioxidant mechanisms can be regarded as a source of stress that may suppress germination. Seed priming was aimed primarily to control seed hydration by lowering external water potential, or shortening the hydration period.",book:{id:"6096",slug:"advances-in-seed-biology",title:"Seed Biology",fullTitle:"Advances in Seed Biology"},signatures:"Awatif S. Ali and Alaaeldin A. Elozeiri",authors:[{id:"207241",title:"Dr.",name:"Awatif",middleName:null,surname:"Ali",slug:"awatif-ali",fullName:"Awatif Ali"}]},{id:"62738",doi:"10.5772/intechopen.79550",title:"The Role of UV-Visible Spectroscopy for Phenolic Compounds Quantification in Winemaking",slug:"the-role-of-uv-visible-spectroscopy-for-phenolic-compounds-quantification-in-winemaking",totalDownloads:2728,totalCrossrefCites:19,totalDimensionsCites:53,abstract:"Phenolic compounds are bioactive substances present in a large number of food products including wine. The importance of these compounds in wine is due to their large effect on the organoleptic attributes of wine. Phenolic compounds play a crucial role in the colour as well as mouthfeel properties of wines. UV-visible spectroscopy appears as a suitable technique for the evaluation of phenolic compounds’ properties and content. The ability of the phenolic ring to absorb UV light and the fact that some of the phenolic substances are coloured compounds, i.e. show absorption features in the visible region, make UV-visible spectroscopy a suitable technique to investigate and quantify grape and wine phenolic compounds. A number of analytical techniques are currently used for phenolic quantification. These include both simpler approaches (spectrophotometric determinations) as well as more complex methodologies such liquid chromatography analysis. Moreover, a number of spectroscopy applications have also been recently reported and are becoming popular within the wine industry. This chapter reviews information on the UV-visible spectral properties of phenolic compounds, changes occurring during wine ageing and also discusses the current UV-visible based analytical techniques used for the quantification of phenolic compounds in grapes and wine.",book:{id:"6878",slug:"frontiers-and-new-trends-in-the-science-of-fermented-food-and-beverages",title:"Frontiers and New Trends in the Science of Fermented Food and Beverages",fullTitle:"Frontiers and New Trends in the Science of Fermented Food and Beverages"},signatures:"Jose Luis Aleixandre-Tudo and Wessel du Toit",authors:[{id:"250919",title:"Dr.",name:"Jose Luis",middleName:null,surname:"Aleixandre-Tudo",slug:"jose-luis-aleixandre-tudo",fullName:"Jose Luis Aleixandre-Tudo"},{id:"261223",title:"Prof.",name:"Wessel",middleName:null,surname:"Du Toit",slug:"wessel-du-toit",fullName:"Wessel Du Toit"}]},{id:"38354",doi:"10.5772/48453",title:"Oxygen Scavengers: An Approach on Food Preservation",slug:"oxygen-scavengers-an-approach-on-food-preservation",totalDownloads:16150,totalCrossrefCites:8,totalDimensionsCites:46,abstract:null,book:{id:"1128",slug:"structure-and-function-of-food-engineering",title:"Structure and Function of Food Engineering",fullTitle:"Structure and Function of Food Engineering"},signatures:"Renato Souza Cruz, Geany Peruch Camilloto and Ana Clarissa dos Santos Pires",authors:[{id:"144206",title:"Dr.",name:"Renato",middleName:null,surname:"Cruz",slug:"renato-cruz",fullName:"Renato Cruz"},{id:"144215",title:"Dr.",name:"Ana Clarissa",middleName:null,surname:"Pires",slug:"ana-clarissa-pires",fullName:"Ana Clarissa Pires"},{id:"144219",title:"MSc.",name:"Geany",middleName:null,surname:"Camilloto",slug:"geany-camilloto",fullName:"Geany Camilloto"}]}],mostDownloadedChaptersLast30Days:[{id:"38363",title:"Pulsed Electric Fields for Food Processing Technology",slug:"pulsed-electric-fields-for-food-processing-technology",totalDownloads:29444,totalCrossrefCites:15,totalDimensionsCites:72,abstract:null,book:{id:"1128",slug:"structure-and-function-of-food-engineering",title:"Structure and Function of Food Engineering",fullTitle:"Structure and Function of Food Engineering"},signatures:"Maged E.A. Mohamed and Ayman H. Amer Eissa",authors:[{id:"147638",title:"Dr.",name:"Maged",middleName:"E. A.",surname:"Mohammed",slug:"maged-mohammed",fullName:"Maged Mohammed"}]},{id:"66671",title:"Extraction and Purification of Pectin from Agro-Industrial Wastes",slug:"extraction-and-purification-of-pectin-from-agro-industrial-wastes",totalDownloads:2721,totalCrossrefCites:1,totalDimensionsCites:9,abstract:"With the advent of science and technology, agro-industrial wastes are converted into various value-added products to meet the demands of increasing population. In recent years, natural polymers have evoked tremendous interest due to easy conversion into value-added products. Apart from various natural polymers, pectin occupied a prominent place due to diverse pharmaceutical and therapeutic applications. Excess utilisation of pectin, the gap between production and demand is widening. To fulfil this gap various techniques are adopted for obtaining high yield pectin from various agro-industrial wastes. This chapter will be focusing on extraction and purification of pectin from various agro-industrial wastes, considered as main environmental pollutants.",book:{id:"8504",slug:"pectins-extraction-purification-characterization-and-applications",title:"Pectins",fullTitle:"Pectins - Extraction, Purification, Characterization and Applications"},signatures:"Erumalla Venkatanagaraju, N. Bharathi, Rachiraju Hema Sindhuja, Rajshree Roy Chowdhury and Yarram Sreelekha",authors:null},{id:"69396",title:"Soybean Amino Acids in Health, Genetics, and Evaluation",slug:"soybean-amino-acids-in-health-genetics-and-evaluation",totalDownloads:1383,totalCrossrefCites:0,totalDimensionsCites:6,abstract:"Soybean is an important source of protein and amino acids for humans and livestock because of its well-balanced amino acid profile. This chapter outlines the strengths and weaknesses of soybean as a complete amino acid source as well as the relative importance of individual amino acids. Special attention is paid to the sulfur-containing amino acids, methionine and cysteine. Breeding and genetic engineering efforts are summarized to highlight previous accomplishments in amino acid improvement and potential avenues for future research. Agronomic properties and processing methods that affect amino acid levels in soybean food and feed are also explained. A brief introduction into current amino acid evaluation techniques is provided. By understanding the complexities of amino acids in soybean, protein quality for humans and livestock can be maximized.",book:{id:"6972",slug:"soybean-for-human-consumption-and-animal-feed",title:"Soybean for Human Consumption and Animal Feed",fullTitle:"Soybean for Human Consumption and Animal Feed"},signatures:"William Monte Singer, Bo Zhang, M.A. Rouf Mian and Haibo Huang",authors:[{id:"308970",title:"Mr.",name:"William",middleName:null,surname:"Singer",slug:"william-singer",fullName:"William Singer"},{id:"309005",title:"Dr.",name:"Bo",middleName:null,surname:"Zhang",slug:"bo-zhang",fullName:"Bo Zhang"},{id:"310776",title:"Dr.",name:"M.A. Rouf",middleName:null,surname:"Mian",slug:"m.a.-rouf-mian",fullName:"M.A. Rouf Mian"},{id:"310777",title:"Dr.",name:"Haibo",middleName:null,surname:"Huang",slug:"haibo-huang",fullName:"Haibo Huang"}]},{id:"56975",title:"Metabolic Processes During Seed Germination",slug:"metabolic-processes-during-seed-germination",totalDownloads:6166,totalCrossrefCites:29,totalDimensionsCites:63,abstract:"Seed germination is crucial stage in plant development and can be considered as a determinant for plant productivity. Physiological and biochemical changes followed by morphological changes during germination are strongly related to seedling survival rate and vegetative growth which consequently affect yield and quality. This study is aimed to focus on proceeding of the most vital metabolic processes namely reserve mobilization, phytohormonal regulation, glyoxylate cycle and respiration process under either stressful or non-stressful conditions that may be led to suggest and conduct the more successful experimental improvements. Seed imbibition triggered the activation of various metabolic processes such as synthesis of hydrolytic enzymes which resulted in hydrolysis of reserve food into simple available form for embryo uptake. Abiotic stresses potentially affect seed germination and seedling establishment through various factors, such as a reduction in water availability, changes in the mobilization of stored reserves, hormonal balance alteration and affecting the structural organization of proteins. Recent strategies for improving seed quality involved classical genetic, molecular biology and invigoration treatments known as priming treatments. H2O2 accumulation and associated oxidative damages together with a decline in antioxidant mechanisms can be regarded as a source of stress that may suppress germination. Seed priming was aimed primarily to control seed hydration by lowering external water potential, or shortening the hydration period.",book:{id:"6096",slug:"advances-in-seed-biology",title:"Seed Biology",fullTitle:"Advances in Seed Biology"},signatures:"Awatif S. Ali and Alaaeldin A. Elozeiri",authors:[{id:"207241",title:"Dr.",name:"Awatif",middleName:null,surname:"Ali",slug:"awatif-ali",fullName:"Awatif Ali"}]},{id:"51587",title:"Casein Proteins: Structural and Functional Aspects",slug:"casein-proteins-structural-and-functional-aspects",totalDownloads:4815,totalCrossrefCites:17,totalDimensionsCites:40,abstract:"Mammalian milk is a complex fluid mixture of various proteins, minerals, and lipids, which play an important role in providing nutrition and immunity to the newborn. Casein proteins, which form about 80% of the bovine milk proteins, form large colloidal particles with calcium phosphate to form casein micelles, which for many years have been an important subject of interest. Casein micelles are composed of four main types of proteins: αS1‐casein, αS2‐casein, β‐casein, and k‐casein. These constituent casein proteins lack well‐defined secondary and tertiary structure due to large amount of propyl residues. These micelles are being extensively studied because of their importance in functional behavior of milk and various milk products. However, the exact structure and nature of these casein micelles are still under debate. These different casein proteins possess different functional properties due to their primary amino acid sequence.",book:{id:"5060",slug:"milk-proteins-from-structure-to-biological-properties-and-health-aspects",title:"Milk Proteins",fullTitle:"Milk Proteins - From Structure to Biological Properties and Health Aspects"},signatures:"Mohd Younus Bhat, Tanveer Ali Dar and Laishram Rajendrakumar\nSingh",authors:[{id:"178323",title:"Dr.",name:"Laishram R",middleName:null,surname:"Singh",slug:"laishram-r-singh",fullName:"Laishram R Singh"},{id:"183444",title:"Mr.",name:"Md. Younus",middleName:null,surname:"Bhat",slug:"md.-younus-bhat",fullName:"Md. Younus Bhat"}]}],onlineFirstChaptersFilter:{topicId:"36",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81975",title:"Self-Sustained Communities: Food Security in Times of Crisis",slug:"self-sustained-communities-food-security-in-times-of-crisis",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.104425",abstract:"The COVID-19 pandemic has caused an increase in the number of poor people around the world and led to the risk of food insecurity on a global scale. Even in Thailand, a country where food production exceeds domestic demand, the COVID-19 pandemic affects food security. The increased unemployment and the consequent loss of income resulting from the pandemics undermine food accessibility and affordability for many people. This chapter addresses the problem of food insecurity in Thailand during and after the COVID-19 crisis. It provides an analysis of the current status of food insecurity and food system resilience in Thailand and suggests solutions. It also proposes the adoption of a “Food Self-Sustained Community (FSSC)” model, which refers to the concept of building food security in a community. By planning and designing in advance, a community can switch its normal form of production seamlessly to a self-sufficiency model that prepares it for future crises, so that the community can produce enough food for all members without relying on sources outside the community.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Kriengsak Chareonwongsak"},{id:"81297",title:"Legumes Cropping and Nitrogen Fixation under Mediterranean Climate: The Case of Montado/Dehesa System",slug:"legumes-cropping-and-nitrogen-fixation-under-mediterranean-climate-the-case-of-montado-dehesa-system",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.104473",abstract:"Climate change contributes to the environmental pressures that the Montado/Dehesa systems are experiencing, leading to an impoverishment of the floristic composition of the understorey. The strongly acidic soils of these systems are associated with nutrient deficiencies, nutritional disorders and the toxicity of metals, especially Mn and Al; these problems are discussed with emphasis on the antagonism between Fe and Mn and the relationship between K concentration and Mg uptake and concentration. The potential for the use of the legume-rhizobia symbiosis to increase biological nitrogen fixation and avenues for research are discussed. The co-colonization of the roots of legumes with arbuscular mycorrhizal (AM) fungi and the effects on P and Mn uptake are discussed. A better understanding of the relationships between soil pH, organic matter content (SOM), microbial community, soil P content and the plant strategies to mobilize it, as well as plant effects on the soil solution concentrations of Mn, is important for the management of these systems. The increase of biological nitrogen fixation in these systems, through the breeding of tolerant cultivars to acidic soils and a stepwise legumes enrichment, alongside soil fertility management, may contribute to increasing biomass production, SOM content and overall ecological plasticity.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Fernando Teixeira"},{id:"81493",title:"Rust Disease Classification Using Deep Learning Based Algorithm: The Case of Wheat",slug:"rust-disease-classification-using-deep-learning-based-algorithm-the-case-of-wheat",totalDownloads:79,totalDimensionsCites:0,doi:"10.5772/intechopen.104426",abstract:"Rusts are plant diseases caused by obligate fungi parasites. They are usually host-specific and cause greater losses of yields in crops, trees, and ornamental plants. Wheat is a staple food crop bearing losses specifically due to three species of rust fungi namely leaf rust (Puccinia triticina), stem rust (Puccinia graminis), and yellow rust (Puccinia striiformis). These diseases are usually inspected manually by a human being but at a large scale, this process is labor-intensive, time-consuming, and prone to human errors. Therefore, there is a need for an effective and efficient system that helps in the identification and classification of these diseases at early stages. In the present study, a deep learning-based CNN (i.e., VGG16) transfer learning model has been utilized for wheat disease classification on the CGIAR image dataset, containing two classes of wheat rust disease (leaf rust and stem rust), and one class of healthy wheat images. The deep learning models produced the best results by tuning the various hyper-parameters such as batch size, number of epochs, and learning rate. The proposed model has reported the best classification accuracy rate of 99.54% on 80 epochs using an initial learning rate from 0.01 and decayed to 0.0001.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Shivani Sood, Harjeet Singh and Suruchi Jindal"},{id:"81235",title:"Global Food System Transformation for Resilience",slug:"global-food-system-transformation-for-resilience",totalDownloads:65,totalDimensionsCites:1,doi:"10.5772/intechopen.102749",abstract:"Our world is incredibly diverse and beautiful, everything we do has an impact on the environment, and our actions are intertwined. Recognizing how our actions affect the Earth on a global scale means, we need to change the way we do things. We must ensure that the value society derives from our actions comes at a low cost to the environment. A sustainable strategy to establish a resilient food system is to ensure that human demand for the Earth’s resources for food is kept within the supply of these resources. While more than 800 million people worldwide suffer from chronic malnutrition, our food systems emit roughly a third of all greenhouse emissions. Also, over 80% of our biodiversity gets lost. Hence, scaling up food system is simply not an option to feed nine to ten billion people by 2050 as we will need to produce more food in the next four decades than all of history’s farmers have harvested in the last eight thousand years. Therefore, rather than upscaling, the global food systems require transformation. Four critical aspects of this transformation include: “Boosting the small; Transforming the Big; Losing Less; and Eating Smarter.” Examining these four areas more deeply, it becomes evident that, while new technology will be critical to the transformation, government involvement, as well as better financial and behavioral change from residents and consumers, will be required. This chapter focuses on these four pillars that make up the global food system transformation for resilience.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Jasper Okoro Godwin Elechi, Ikechukwu U. Nwiyi and Cornelius Smah Adamu"},{id:"80749",title:"Analysis of the Nexus between Coping Strategies and Resilience to Food Insecurity Shocks: The Case of Rural Households in Boricha Woreda, Sidama National Regional State, Ethiopia",slug:"analysis-of-the-nexus-between-coping-strategies-and-resilience-to-food-insecurity-shocks-the-case-of",totalDownloads:67,totalDimensionsCites:1,doi:"10.5772/intechopen.102613",abstract:"This chapter reports on the coping strategies employed by households in the event of food insecurity shocks and the nexus between the types of coping strategies and resilience to food insecurity in one of the food-stressed woreda from Sidama National Regional State, Ethiopia. The households use various consumption-based coping strategies that run from compromising the quality of food-to-food rationing. Repeatedly occurring food shortage has also forced some households to employ resilience erosive coping mechanisms such as selling reproductive assets. Such coping strategies have an important implication on the household’s capacity to cope with the future food insecurity-related shocks, with a statistically significant relationship between the nature of coping strategies utilized in response to previous food insecurity-related shocks and the household’s resilience to upcoming shocks. Coordinating crises management based on humanitarian intervention with households’ livelihood assets protection and resilience strengthening is the major policy implication of this study.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Adane Atara Debessa, Degefa Tolossa and Berhanu Denu"},{id:"80753",title:"Toward Safe Food Systems: Analyses of Mycotoxin Contaminants in Food and Preventive Strategies Thereof for Their Formation and Toxicity",slug:"toward-safe-food-systems-analyses-of-mycotoxin-contaminants-in-food-and-preventive-strategies-thereo",totalDownloads:64,totalDimensionsCites:0,doi:"10.5772/intechopen.101461",abstract:"Mycotoxin contaminants in food pose a threat to human and animal health. These lead to food wastage and threaten food security that is already a serious problem in Africa. In addition, these affect trading and especially affect incomes of rural farmers. The broad impacts of these contaminants require integrated solutions and strategies. It is thus critical to not only develop strategies for analysis of these toxins but also develop removal and preventive strategies of these contaminants to ensure consumer safety and compliance with regulatory standards. Further within the aim of promoting food safety, there is need for operational policy framework and strategy on the management of these contaminants to promote their mitigation. This chapter discusses integrated strategies for monitoring and control of mycotoxin contamination in food matrices to promote their mitigation and build resilient food systems in Africa and thus reinforce efforts to reach sustainable food security.",book:{id:"10897",title:"Food Systems Resilience",coverURL:"https://cdn.intechopen.com/books/images_new/10897.jpg"},signatures:"Dikabo Mogopodi, Mesha Mbisana, Samuel Raditloko, Inonge Chibua and Banyaladzi Paphane"}],onlineFirstChaptersTotal:10},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:32,numberOfPublishedChapters:319,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:141,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:133,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:5,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:16,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/23.jpg",latestPublicationDate:"June 25th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"280770",title:"Dr.",name:"Katherine K.M.",middleName:null,surname:"Stavropoulos",slug:"katherine-k.m.-stavropoulos",fullName:"Katherine K.M. Stavropoulos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRdFuQAK/Profile_Picture_2022-05-24T09:03:48.jpg",biography:"Katherine Stavropoulos received her BA in Psychology from Trinity College, in Connecticut, USA. Dr. Stavropoulos received her Ph.D. in Experimental Psychology from the University of California, San Diego. She completed her postdoctoral work at the Yale Child Study Center with Dr. James McPartland. Dr. Stavropoulos’ doctoral dissertation explored neural correlates of reward anticipation to social versus nonsocial stimuli in children with and without autism spectrum disorders (ASD). 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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