Mechanical properties of host structure and piezoelectric patch
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More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"10203",leadTitle:null,fullTitle:"Dyes and Pigments - Novel Applications and Waste Treatment",title:"Dyes and Pigments",subtitle:"Novel Applications and Waste Treatment",reviewType:"peer-reviewed",abstract:"Dyes and pigments have been utilized since ancient times. They play an important role in everyday life and their use is interwoven with human culture. Even though numerous dyes and pigments have been synthesized to date, and a lot of knowledge has been gained regarding their production and properties, scientific research is pushing the boundaries towards novel dyes and pigments for high-tech applications. At the same time, the accumulation of dyes and pigments in natural environments and pollution of water resources due to their massive use are important consequences to consider. New methods for the degradation and removal of dyes and pigments from affected areas are highly sought after. As such, this book examines new trends in smart and functional dyes and pigments and their uses as well as novel treatment approaches to dye and pigment waste.",isbn:"978-1-83968-615-3",printIsbn:"978-1-83968-614-6",pdfIsbn:"978-1-83968-616-0",doi:"10.5772/intechopen.90970",price:119,priceEur:129,priceUsd:155,slug:"dyes-and-pigments-novel-applications-and-waste-treatment",numberOfPages:216,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"624f533946a159bc8a03f109c2e1dc91",bookSignature:"Raffaello Papadakis",publishedDate:"July 21st 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10203.jpg",numberOfDownloads:3960,numberOfWosCitations:0,numberOfCrossrefCitations:2,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:7,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:9,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 28th 2020",dateEndSecondStepPublish:"September 25th 2020",dateEndThirdStepPublish:"November 24th 2020",dateEndFourthStepPublish:"February 12th 2021",dateEndFifthStepPublish:"April 13th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"251885",title:"Dr.",name:"Raffaello",middleName:null,surname:"Papadakis",slug:"raffaello-papadakis",fullName:"Raffaello Papadakis",profilePictureURL:"https://mts.intechopen.com/storage/users/251885/images/system/251885.png",biography:"Raffaello holds a Chemical Engineering Diploma (2005) and a PhD degree in the field of physical organic chemistry (2010), both from the National Technical University of Athens, Greece. During his PhD, he specialized in the synthesis of solvatochromic probes and molecular switches. \n\nIn 2010 he moved to Marseille, France (September 2010–January 2013) to start working as a researcher at the Institute of Molecular Sciences, CNRS/Aix-Marseille University, in the field of water oxidation catalysts in the research group of Dr. Thierry Tron.\n\nRaffaello subsequently joined the group of Dr. Henrik Ottosson (2014 Uppsala University) where he worked as a PostDoc and later on as a researcher focusing on excited state (anti)aromaticity and graphene photochemistry. \n\nHis research interests revolve around physical organic and materials chemistry with an emphasis on the chemistry and photochemistry of graphene as well as polysaccharide chemistry. He is the author and co-author of 30 peer-reviewed scientific papers, four book chapters and has more than 35 contributions in international conference proceedings. \n\nFurthermore, Raffaello is an active referee of scientific peer-reviewed papers of world-class chemistry journals and he has acted repeatedly as a scientific expert evaluating international research grant proposals (including EU-grant applications). He is also the academic editor of a Book related to Dyes and Pigments and the Molecules (MDPI) issue: “Coupling Heterocyclic to Graphene Chemistry: Syntheses, Functionalizations, Interactions and Catalysis”. \n\nCurrently, in his work at TdB Labs as a senior research scientist, Raffaello is particularly interested in polysaccharide fluorescent labeling as well as fluorescent dyes and their applications.",institutionString:"TdB Labs",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Uppsala University",institutionURL:null,country:{name:"Sweden"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"296",title:"Textile Engineering",slug:"textile-engineering"}],chapters:[{id:"77175",title:"Introductory Chapter: Dyes and Pigments - Past, Present, and Future",doi:"10.5772/intechopen.98599",slug:"introductory-chapter-dyes-and-pigments-past-present-and-future",totalDownloads:154,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Raffaello Papadakis",downloadPdfUrl:"/chapter/pdf-download/77175",previewPdfUrl:"/chapter/pdf-preview/77175",authors:[{id:"251885",title:"Dr.",name:"Raffaello",surname:"Papadakis",slug:"raffaello-papadakis",fullName:"Raffaello Papadakis"}],corrections:null},{id:"76890",title:"Probing Solvation Effects in Binary Solvent Mixtures with the Use of Solvatochromic Dyes",doi:"10.5772/intechopen.98180",slug:"probing-solvation-effects-in-binary-solvent-mixtures-with-the-use-of-solvatochromic-dyes",totalDownloads:235,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"In this work three molecules exhibiting dual sensing solvatochromic behaviors are examined in the context of solvation in binary solvent mixtures (BSMs). The compounds studied involve two functional groups with high responsiveness to solvent polarity namely pentacyanoferrate(II) (PC) and azo groups. Two of these compounds are [2]rotaxanes involving alpha- or beta- cyclodextrin (CyD) and the third is their CyD-free precursor. The dual solvatochromic behavior of these compounds is investigated in water/ethlylene glycol (EG) mixtures and their dual solvatochromic responses are assessed in terms of the intensity of solvatochromism and the extent of preferential solvation. To achieve this the linear solvation model by Kamlet, Abboud and Taft [J. Organomet. Chem. 1983, 48, 2877–2887] and the two-phase model of solvation by Bagchi and coworkers [J. Phys. Chem. 1991, 95, 3311–3314] are employed. The influence of the presence or lack of CyD (alpha- or beta-) on these dual solvatochromic sensors is analyzed.",signatures:"Ioanna Deligkiozi and Raffaello Papadakis",downloadPdfUrl:"/chapter/pdf-download/76890",previewPdfUrl:"/chapter/pdf-preview/76890",authors:[{id:"251885",title:"Dr.",name:"Raffaello",surname:"Papadakis",slug:"raffaello-papadakis",fullName:"Raffaello Papadakis"},{id:"252046",title:"Dr.",name:"Ioanna",surname:"Deligkiozi",slug:"ioanna-deligkiozi",fullName:"Ioanna Deligkiozi"}],corrections:null},{id:"75483",title:"Dyes as Labels in Biosensing",doi:"10.5772/intechopen.96540",slug:"dyes-as-labels-in-biosensing",totalDownloads:350,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Investigation and evaluation of dyes play a vital role in the process of introduction novel labels and their corresponding sensing methods, which signify opportunities for the development of biosensors. This chapter introduces applications of various dyes as labels in biosensing. Bio-recognition molecules with dyes transduce biological information into measurable optical, electrochemical, magnetic or other kinds of signals for quantification. The dyes used in this field were summarized and reviewed according to their signal types, namely colorimetric, fluorescent and electrochemical. Some dyes can transduce signals between multiple physical signals. For some most important dyes, detailed descriptions were given focused on their unique properties, labeling methods and sensing mechanisms.",signatures:"Hu Li, Yuanyuan Han, Haiyan Zhao, Hassan Jafri and Bo Tian",downloadPdfUrl:"/chapter/pdf-download/75483",previewPdfUrl:"/chapter/pdf-preview/75483",authors:[{id:"328317",title:"Prof.",name:"Hu",surname:"Li",slug:"hu-li",fullName:"Hu Li"},{id:"332401",title:"Dr.",name:"Yuanyuan",surname:"Han",slug:"yuanyuan-han",fullName:"Yuanyuan Han"},{id:"332404",title:"Dr.",name:"Bo",surname:"Tian",slug:"bo-tian",fullName:"Bo Tian"},{id:"332405",title:"Dr.",name:"Haiyan",surname:"Zhao",slug:"haiyan-zhao",fullName:"Haiyan Zhao"},{id:"341008",title:"Prof.",name:"Syed Hassan Mujtaba",surname:"Jafri",slug:"syed-hassan-mujtaba-jafri",fullName:"Syed Hassan Mujtaba Jafri"}],corrections:null},{id:"76485",title:"Natural Dyes: From Cotton Fabrics to Solar Cells",doi:"10.5772/intechopen.97487",slug:"natural-dyes-from-cotton-fabrics-to-solar-cells",totalDownloads:276,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This article will discuss natural dyes’ role, from colouring the cotton fabrics with some functionality to harvesting sunlight in the dye-sensitized solar cells. Natural dye colourants are identical to the low light- and wash-fastness. Therefore, an approach to improving the colourant’s physical properties is necessary. Colouring steps employing silica nanosol and chitosan will be presented. The first part will be these multifunctional natural dye coatings on cotton fabrics. Then, functionality such as hydrophobic surfaces natural dyed cotton fabrics will be discussed. Natural dyes are also potential for electronic application, such as solar cells. So, the second part will present natural dyes as the photosensitizers for solar cells. The dyes are adsorbed on a semiconductor oxide surface, such as TiO2 as the photoanode. Electrochemical study to explore natural dyes’ potential as sensitizer will be discussed, for example, natural dyes for Batik. Ideas in improving solar cell efficiency will be discussed by altering the photoanode’s morphology. The ideas to couple the natural dyes with an organic–inorganic hybrid of perovskite and carbon dots are then envisaged.",signatures:"Indriana Kartini and Adhi Dwi Hatmanto",downloadPdfUrl:"/chapter/pdf-download/76485",previewPdfUrl:"/chapter/pdf-preview/76485",authors:[{id:"179563",title:"Dr.",name:"Indriana",surname:"Kartini",slug:"indriana-kartini",fullName:"Indriana Kartini"},{id:"351799",title:"Dr.",name:"Adhi Dwi",surname:"Hatmanto",slug:"adhi-dwi-hatmanto",fullName:"Adhi Dwi Hatmanto"}],corrections:null},{id:"75235",title:"Photochromic Dyes for Smart Textiles",doi:"10.5772/intechopen.96055",slug:"photochromic-dyes-for-smart-textiles",totalDownloads:513,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Photochromism is a light induced reversible color change phenomenon in photochromic molecule due to light and heat effect and molecular species exist in two forms which have different absorption spectra. The fascinating color change by photochromic molecules in response to specific wavelength of light produces number of applications such as U.V. protective fabrics, ophthalmic photochromic lenses, optical data storing, optical switch, sensors and display. This chapter provides a brief and conclusive review of photochromism their mechanism and application in Textiles. Although photochromic materials are in use since 1960 in lenses and sunglasses, but the development is slow due to technical difficulties and poor commercial application. Now there is renewed interest in photochromic materials which are used in nanofibers in smart textiles and in allied items.",signatures:"Virendra Kumar Gupta",downloadPdfUrl:"/chapter/pdf-download/75235",previewPdfUrl:"/chapter/pdf-preview/75235",authors:[{id:"305259",title:"Dr.",name:"Virendra",surname:"Kumar Gupta",slug:"virendra-kumar-gupta",fullName:"Virendra Kumar Gupta"}],corrections:null},{id:"76188",title:"Application of Smart and Functional Dyes in Textiles",doi:"10.5772/intechopen.96045",slug:"application-of-smart-and-functional-dyes-in-textiles",totalDownloads:390,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Our future will be based on functional and AI based smart products, where every industry wants to develop these kinds of products. Textile industry also cannot remain untouched with this technological innovation. Dyes have been utilising for coloration of textiles since ancient time. But at present with various advancement in technology as well as requirements of consumers, the need for functional and smart dyes arises. Various current researches are based on application of smart and functional dyes on textile to develop smart and functional textiles. The dyes which add the functional and smart properties to the textiles can be called as functional and smart dyes. Functional and smart dyes are available in both synthetic and natural form. But with the environment concern, the researchers are going on to find out natural source of these dyes. Functional dyes such as UV protective dye, antimicrobial dye, moth repellent dye offer specific function after application on textiles. Smart dyes like photochromic, thermochromic, electrochromic and solvatochromic etc. are playing very imp role to develop a smart textile which can offer reversible colour change which leads to impart various properties such as thermoregulation, camophlage properties into the textiles. Functional dyes generally limited to the textiles sector but smart dyes are not just restricted to it. Application of smart dyes is extended to various fields such as automobiles, robotics, aircrafts, medicine and surgery etc. This chapter will mainly deal with the types, application methods and application area of functional and smart dyes especially in connection with textiles.",signatures:"Deepti Pargai",downloadPdfUrl:"/chapter/pdf-download/76188",previewPdfUrl:"/chapter/pdf-preview/76188",authors:[{id:"229144",title:"Dr.",name:"Deepti",surname:"Pargai",slug:"deepti-pargai",fullName:"Deepti Pargai"}],corrections:null},{id:"74585",title:"Applications of Metal Complexes Dyes in Analytical Chemistry",doi:"10.5772/intechopen.95304",slug:"applications-of-metal-complexes-dyes-in-analytical-chemistry",totalDownloads:291,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Trace elements, especially heavy metals, are considered to be one of the main sources of pollution in the environment since they have a significant effect on ecological quality. Commonly, the analytical methods for the determination of trace metals are the spectrometry techniques. While, the electroanalytical methods are recognized as a powerful technique for trace metals owing to its remarkable sensitivity, relatively inexpensive instrumentation, ability for multi-element determination at trace and ultra trace level. New alternative electrode materials are highly desired to develop sensitive stripping sensors for meeting the growing demands for on-site environmental monitoring. Dyes aromatic heterocyclic compound, used in food, textile and cosmetic industries has been used for spectrophotometric determination of metals. In electrochemitry, methods for metals determination based on their complexation with dyes were proposed. In this chapter, a brief summary of spectrometry methods and electrochemical sensors for heavy metals detection based on the formation of metals dyes complexes is presented.",signatures:"Mariame Coulibaly",downloadPdfUrl:"/chapter/pdf-download/74585",previewPdfUrl:"/chapter/pdf-preview/74585",authors:[{id:"230530",title:"Dr.",name:"Mariame",surname:"Coulibaly",slug:"mariame-coulibaly",fullName:"Mariame Coulibaly"}],corrections:null},{id:"76561",title:"Structure and Properties of Dyes and Pigments",doi:"10.5772/intechopen.97104",slug:"structure-and-properties-of-dyes-and-pigments",totalDownloads:798,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Colour is one of the elements of nature that makes human life more aesthetic and fascinating in the world. Plants, animals, and minerals have been used as primary sources for colourants, dyes or pigments since ancient times. In our daily life, we know about many substances which have specific colours. These are the substances which are used as colourants i.e.; colour imparting species. Both dyes and pigments are coloured as they absorb only some wavelength of visible light. Their structures have Aryl rings that have delocalized electron systems. These structures are said to be responsible for the absorption of electromagnetic radiation that has varying wavelengths, based upon the energy of the electron clouds. Dyes are coloured organic compounds that are used to impart colour to various substrates, including paper, leather, fur, hair, drugs, cosmetics, waxes, greases, plastics and textile materials. A Dye is a coloured compound due to the presence of chromophore and its fixed property to the acid or basic groups such as OH, SO3H, NH2, NR2, etc. The polar auxochrome makes the dye water-soluble and binds the dye to the fabric by interaction with the oppositely charged groups of the fabric structure. Pigments are organic and inorganic compounds which are practically insoluble in medium in which they are incorporated. Dyes and pigments are the most important colourants used to add colour or to change the colour of something. They are widely used in the textile, pharmaceutical, food, cosmetics, plastics, paint, ink, photographic and paper industries. This chapter is devoted to the structure and properties of dyes and pigments.",signatures:"Ashok Kumar, Utkarsh Dixit, Kaman Singh, Satya Prakash Gupta and Mirza S. Jamal Beg",downloadPdfUrl:"/chapter/pdf-download/76561",previewPdfUrl:"/chapter/pdf-preview/76561",authors:[{id:"289139",title:"Mr.",name:"Ashok",surname:"Kumar",slug:"ashok-kumar",fullName:"Ashok Kumar"},{id:"347915",title:"Mr.",name:"Utkarsh",surname:"Dixit",slug:"utkarsh-dixit",fullName:"Utkarsh Dixit"},{id:"347916",title:"Prof.",name:"Kaman",surname:"Singh",slug:"kaman-singh",fullName:"Kaman Singh"},{id:"352123",title:"Dr.",name:"Satya Prakash",surname:"Gupta",slug:"satya-prakash-gupta",fullName:"Satya Prakash Gupta"}],corrections:null},{id:"75257",title:"A Brief Comparative Study on Removal of Toxic Dyes by Different Types of Clay",doi:"10.5772/intechopen.95755",slug:"a-brief-comparative-study-on-removal-of-toxic-dyes-by-different-types-of-clay",totalDownloads:280,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Increasing amount of organic dyes in the ecosystem particularly in wastewater has propelled the search for more efficient low-cost bio adsorbents. Different techniques have been used for the treatment of wastewater containing toxic dyes such as: biological degradation, oxidation, adsorption, reverse osmosis, and membrane filtration. Among all these processes mentioned, adsorption with low cost adsorbents has been recognized as one of the cost effective and efficient techniques for treatment of industrial wastewater from organic and inorganic pollutants. Clays as material adsorbents for the removal of various toxic dyes from aqueous solutions as potential alternatives to activated carbons has recently received widespread attention because of the environmental-friendly nature of clay materials. This chapter presents a comprehensive account of the techniques used for the removal of industrial cationic and anionic dyes from water during the last 10 years with special reference to the adsorption by using low cost materials in decontamination processes. Effects of different adsorption parameters on the performance of clays as adsorbents have been also discussed. Various challenges encountered in using clay materials are highlighted and a number of future prospects for the adsorbents are proposed.",signatures:"Ahmed Zaghloul, Ridouan Benhiti, Rachid Aziam, Abdeljalil Ait Ichou, Mhamed Abali, Amina Soudani, Fouad Sinan, Mohamed Zerbet and Mohamed Chiban",downloadPdfUrl:"/chapter/pdf-download/75257",previewPdfUrl:"/chapter/pdf-preview/75257",authors:[{id:"312525",title:"Prof.",name:"Mohamed",surname:"Chiban",slug:"mohamed-chiban",fullName:"Mohamed Chiban"},{id:"345722",title:"Dr.",name:"Abdeljalil",surname:"Ait Ichou",slug:"abdeljalil-ait-ichou",fullName:"Abdeljalil Ait Ichou"},{id:"347556",title:"Dr.",name:"Ahmed",surname:"Zaghloul",slug:"ahmed-zaghloul",fullName:"Ahmed Zaghloul"},{id:"347558",title:"Dr.",name:"Ridouan",surname:"Benhiti",slug:"ridouan-benhiti",fullName:"Ridouan Benhiti"},{id:"347559",title:"Dr.",name:"Rachid",surname:"Aziam",slug:"rachid-aziam",fullName:"Rachid Aziam"},{id:"347560",title:"Dr.",name:"Mhamed",surname:"Abali",slug:"mhamed-abali",fullName:"Mhamed Abali"},{id:"347561",title:"Dr.",name:"Amina",surname:"Soudani",slug:"amina-soudani",fullName:"Amina Soudani"},{id:"347562",title:"Dr.",name:"Fouad",surname:"Sinan",slug:"fouad-sinan",fullName:"Fouad Sinan"},{id:"347563",title:"Dr.",name:"Mohamed",surname:"Zerbet",slug:"mohamed-zerbet",fullName:"Mohamed Zerbet"}],corrections:null},{id:"74930",title:"Preparation of Functionalized Hydroxyapatite with Biopolymers as Efficient Adsorbents of Methylene Blue",doi:"10.5772/intechopen.95347",slug:"preparation-of-functionalized-hydroxyapatite-with-biopolymers-as-efficient-adsorbents-of-methylene-b",totalDownloads:303,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In this study, we reported the synthesis of hydroxyapatite modified with biopolymers as λ-carrageenan and sodium alginate, which could be used as effective adsorbents of cationic dyes. Evidence of chemical modification was proved through chemical analysis, Fourier Trans-form Infrared spectroscopy, powder X-ray diffraction, scanning electron microscopy, and specific surface area. The adsorption process was studied using methylene blue as representative cationic dye. The adsorbed quantity reached, at equilibrium, 142.85 mg/g and 98.23 mg/g using hydroxyapatite-sodium alginate and hydroxyapatite-(λ-carrageenan), respectively. However, it does not exceed 58.8 mg/g in the case of the unmodified hydroxyapatite. The adsorption of methylene blue using hybrid materials complied well with the pseudo-second-order suggesting a chemi-sorption. Freundlich and Langmuir isotherm described well the adsorption mechanism of the hydroxyapatite-(λ-carrageenan) and hydroxyapatite-sodium alginate, respectively. The high capacities of MB removal obtained in this study suggest the potential use of these materials in the treatment from wastewaters.",signatures:"Hassen Agougui, Youssef Guesmi and Mahjoub Jabli",downloadPdfUrl:"/chapter/pdf-download/74930",previewPdfUrl:"/chapter/pdf-preview/74930",authors:[{id:"226318",title:"Dr.",name:"Mahjoub",surname:"Jabli",slug:"mahjoub-jabli",fullName:"Mahjoub Jabli"},{id:"330245",title:"Associate Prof.",name:"Hassen",surname:"Agougui",slug:"hassen-agougui",fullName:"Hassen Agougui"},{id:"339741",title:"Dr.",name:"Youssef",surname:"Guesmi",slug:"youssef-guesmi",fullName:"Youssef Guesmi"}],corrections:null},{id:"74730",title:"Treatment of Textile Dyeing Waste Water Using TiO2/Zn Electrode by Spray Pyrolysis in Electrocoagulation Process",doi:"10.5772/intechopen.95325",slug:"treatment-of-textile-dyeing-waste-water-using-tio-sub-2-sub-zn-electrode-by-spray-pyrolysis-in-elect",totalDownloads:371,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"An alternative form of treatment for the remediation of textile waste water, electrocoagulation (EC) methods are used. This work deals mainly with the treatment of waste water for textile dyeing preceded by the use of wastewater. The goal of the proposed study is to evaluate the efficiency of the electrocoagulation process using TiO2/Zn electrodes using TiCl3 via spray pyrolysis. The surface morphology of the electrode was studied by SEM, XRD and EDS analysis. The efficiency of electrocoagulation treatment process to treat synthetic waste water containing Coralene Navy RDRLSR, Coralene Red 3G, Rubru RD GLFI dye was studied. The effect of parameters such as current density, influence of effluent pH, supporting electrolyte NaCl concentration, and EC time on dye removal efficiency were investigated. The result indicates that this process is very efficient and was able to achieve color removal (99.5%) at pH 8.5 and 0.15 A in 10 minutes.",signatures:"Parameswari Kalivel",downloadPdfUrl:"/chapter/pdf-download/74730",previewPdfUrl:"/chapter/pdf-preview/74730",authors:[{id:"335736",title:"Dr.",name:"Parameswari",surname:"Kalivel",slug:"parameswari-kalivel",fullName:"Parameswari Kalivel"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"9203",title:"Chemistry and Technology of Natural and Synthetic Dyes and Pigments",subtitle:null,isOpenForSubmission:!1,hash:"126a19fe8435f744b10161895ed51116",slug:"chemistry-and-technology-of-natural-and-synthetic-dyes-and-pigments",bookSignature:"Ashis Kumar Samanta, Nasser S. 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Mechanical vibrations cause undesirable effects such as noise and acoustic signature and consequences of severe vibrations may lead to a decrease in service life of machines, or even cause damages on the components. In order to reduce vibration levels in ground,marine and aerospace applications as well as nano and micro devices, active control methods for vibration and noise reduction has been proposed in the last decade.
In 1980s, the usages of large structures as the components of the space vehicles were resulted in new challenges in vibration control since these structures are lightly damped and have long decay times. Researchers were motivated to design and implement active vibration control to these lightly damped structures with piezoelectric materials. In one of the first research studies relevant to this area, Bailey and Hubbard[1] designed an active damper system by using piezoelectric material as distributed actuator for the vibration suppression of a cantilever beam. Subsequently, Crawley and Luis[2] developed and experimentally verified the analytical model of piezoelectric materials. The main contribution of Crawley and Luis was the accurate prediction of performance and effectiveness of piezoelectric materials when they are used as actuators. While passive isolation techniques are not generally feasible and efficient for low frequency vibration suppression; aforementioned initiative studies showed that piezoelectric materials can be used to suppress the low frequency vibration. Indeed, Ro and Baz[3] investigated and compared the overall effectiveness of the active and passive treatments for vibration and noisereduction. Their resultsrevealed that active treatments such as bonded piezoelectric patch actuators can significantly reduce the vibration and noise radiation better than the passive treatments. Currently, different types of piezoelectric elements are available in market which can be employed widely as actuators and sensors for active vibration reduction of structures.
In the literature, there are published review articles discussing fundamental aspects of active vibration control. Rao and Sunar[4] published a review paper on the use of piezoelectric materials as sensors and actuators for control of flexible structures. In this review paper, they presented the general framework of structural control strategies and presented the applications in various fields. One of the most common application areas is aerospace industry, since the aerospace structures are flexible and have limited tolerance for vibration. In a different review study, Loewy[5]presented the key applications of smart structures in aeronautical applications with potential usages. In this work, smart materials are categorized in terms of their energy-exchange capabilities. The benefits of using smart structures in aeronautical applications are also presented.
The active vibration control systems should be feasible and reliable to be used in marine, aerospace and automotive applications. The reliability and feasibility of the control systems are related to dynamics of piezoelectric actuators and implementation of controller algorithms. Thus, it is needed to predict performance of the piezoelectric sensor and actuators embedded in control systems before implementation and production. For this purpose, Chee et al.[6] presented the modeling approaches for performance investigation of piezoelectric materials. As discussed in their article, analytical and finite element modeling of piezoelectric materials with host structures can be built using the linear constitutive piezoelectric equations only for low actuation authority.In case of high actuation authority; the nonlinearitiesoccurs and different methodologies should be considered.
The choice of the controller type and optimal positioning of sensors and actuators are other important aspects of design and implementation of active vibration control systems. There are also published technical review papers discussing the controller algorithms and optimal placement of actuators and sensors. For instance, Alkhatib and Golnaraghi[7] reviewed the controller architectures and presented the general design procedures for the active vibration control systems. In this review paper, the advantages and disadvantages of different controller architectures with various application examples are presented. Specifically that review paper states that the active damping system is advantageous when the vibration suppression is aimed only around resonance frequencies. It is also noted that the active damping system ensures stability when collocated sensor and actuator pairs are used. In another review paper, Gupta et al.[8] concentrated on the optimal positioning of piezoelectric sensors and actuators. In this technical review, the optimization techniques are presented based upon six optimizing criteria, namely (i) maximizing modal forces/moments applied by piezoelectric actuators, (ii) maximizing deflection of the host structure, (iii) minimizing control effort/maximizing energy dissipated, (iv) maximizingdegree of controllability, (v) maximizing degree of observability, and (vi) minimizing spill-over effects. Gupta et al. presented the optimal positioning results in the literature in a tabular form for beam and plate like structures.
For robust and adaptive active vibration control systems, the structural modeling techniques and estimation of uncertainties are important. A comprehensive methodology for the design and validation of a robust controller is presented by Iorga et al. [9]. In their paper, structuralmodeling techniques with uncertainty analysis areexplained and
The piezoelectric materials also attracted attention of the researchers working on noise reduction. In a review paper on smart structures and integrated systems, Chopra[10] stated that most of the applications for aerospace vehicles are focused on minimization of vibration levels; however, interior and exterior noise reduction, using piezoelectric materials is also a potential research area for transport vehicles. Hanselka[11] named the use of smart materials in active noise and vibration control as an innovative technology and gave an application example of active noise reduction. In thatapplication, piezoelectric materials served as sensors and actuators to reduce structural-borne noise and the results showed that the application of current developments is possible and advantageous.
This chapter is organized as follows. In section 2, the design procedure and algorithms for active vibration and noise control systems are explained briefly. In section 3, a proportional velocity feedback implementation for active vibration control system developed in our laboratory is presented. Finally, the vibration and noise reduction performance of the controller is discussed.
Undesired mechanical vibrations and noise can be avoided or minimized by active vibration and noise control systems. The design of such systems starts with the dynamic characterization of the target structure that is called host structure for embedding or bonding the smart materials. The dynamic characterization procedure can be carried out numerically and/or experimentally by investigating the vibration characteristics of the structure. By utilizing sensors and actuators, system identification methods can be applied for modeling the whole system. The next step is the reduction of the developed model such that the computations can be performed in a reasonable time.In fact, the model reduction techniques shall be applied while considering the controllability and observability properties of the system. The steps between the characterization of the host structure and the reduced order model are referred as “modeling stage”. Having determined the reduced-order model, the controller is designed and configured until the performance objectives are met. This stage is called the controller stage where the aim is to design and implement the controller for the performance requirements. The design steps of modeling and controller stages are presented in flow chart by Preumont [12] and depicted in Fig. 1. In the next section, the controller architectures will be discussed in detail.
This section presents an overview of controller algorithms for active vibration and noise control systems. In general, the controllers are designed for two different tasks: tracking a trajectory or rejecting disturbances. For active vibration suppression systems, the task is the rejection of external disturbances and reduction of vibration levels. These can be achieved via feedback and feedforward controllers. The generic block diagrams [7] of these controller algorithms are presented in Fig. 2a and\n\t\t\t\t\t\tFig. 2b. Basically, the feedback controller generates controller output signal based on summation of plant response and external disturbance. On the other hand,feedforward controller generates controller output by measuringexternal disturbance and predicting the plant response.
Control System Design Steps
The feedback controller algorithms can be divided into two categories[13] : active damping systems and model-based controllers. In an active damping system, the vibration of the host structure (acceleration, velocity or displacement) can be suppressed around the resonance frequencies. The closed-loop transfer function of the active damping system can be derivedby using the block diagram shown in Fig. 2a as it follows:
Here, the sensor output signal is denoted by y, external disturbance is shown with d and controller output is u. The open-loop system is presented with G(s) in Laplace domain. After algebraic manipulations, one can obtain the following relation for the closed-loop system:
In Equation 2, the closed-loop transfer function shows that the effect of external disturbance on the sensor output can be minimized by increasing the magnitude of the
a) Feedback control block diagram b) Feedforward control block diagram
In the case of model-based controller, the open-loop system dynamics is represented with the state-space model as in Equation 3:
In this state-space form,
The aim of this state-space closed-loop system is to eliminate the effect of disturbance on output signal similar to the active damping. The gain matrix
For control applications, it is necessary to understand the system dynamics appropriately since the controller design parameters are determined based on the system dynamics. As stated in section 2.2 there are different types of the control algorithms and for each type of the controller,system identification is essential. This system identification can be carried out via a vibration testing& analysis methods. Aim of such method is to extract Frequency Response Functions (FRF) where these functionspresents the system response to a specific input in frequency range of interest by means of magnitude and phase. A representative FRF is shown in Fig. 3 for a structure where piezoelectric materials are used as bonded patch actuators (to excite the structure) and LDV as velocity sensor (to measure the vibration response).
Example FRF of a system
The modal (resonance) frequencies of the systems are indicated in magnitude plot of FRFs as sharp peaks where the active damping systems are most effective. In active damping systems, the higher frequency modes may deteriorate the stability due to phase lag. Such effects of the higher frequency modes can be suppressed by including the low-pass filters. On the other hand, model based controllers usemathematical relations which in turn represents the system response based on FRF. Since the scope of this chapter is devoted only to proportional analog velocity feedback controller, more detailed information on model-based controllers and mathematical system representations can be found in references [6, 7, 9, and 12].
In this section an active vibration control system using an analog velocity feedback algorithm is described. At first, the system architecture is explained. Later, the controller design and implementation steps are discussed. In the final step, the evaluation of the controller performance is presented.
The structure used in this study is a rectangular box (1 x 1 x 2 m) and shown in Fig. 4. The surrounding cavity walls are constructed using wood filled concrete with a thickness of 10 mm. This box is separated inside with a thin plate to obtain two enclosed compartments. The two compartments are used for investigation of vibration and noise transmission. The thin steel separation plate (1 x 1 m) in the rectangular box has a thickness 1.8 mm and clamped along on all four edges.
Rectangular box for vibration and noise reduction experiments
In the presence of mechanical and acoustical vibrations, the thin separation plate transmits the vibration and noise to the compartments. By attenuating vibrations of the separation plate, the noise radiation can be also reduced. In this study, the piezoelectric patch actuators bonded on the separation plate are employed as actuators to control and suppress vibration. The piezoelectric actuator is a PI Dura-act 875 bender type piezoelectric patch. This type of patch is compact, lightweight and insulated so it can be easily attached to the host structure and it does not add additional weight. The mechanical properties of the steel and piezoelectric patches are given in Table 1.
Since the piezoelectric materials generate high strain on the host structure, the most effective position for the piezoelectric patch is around the high strain regions on the host structure. In fact, for a clamped-clamped plate, the maximum curvature (highest strain region) changes over the surface for each vibration mode. The maximum curvature of the first mode of a clamped-clamped plate occurs at the center and along the edges; whereas in the second vibration mode, maximum curvature is in the middle of the upper and lower halves of the plate. After these high strain regions are identified, the piezoelectric patches are attached to the center and upper-left (-35 cm, 35 cm from the left upper corner) of the plate in order to suppress first two modes. For suppression of vibration and noise, two piezoelectric patches are used in independent and pair configuration. Fig. 5 shows the thin-separation plate and piezoelectric patches.
Property | Steel | Piezoelectric Patch |
Length (mm) | 1000 | 65 |
Width (mm) | 1000 | 31 |
Depth (mm) | 1.5 | 0.5 |
Elastic modulus (GPA) | 190 | 70.2 |
Poisson’s ratio | 0.33 | 0.36 |
Density (kg/m3) | 6305 | 7800 |
Piezoelectric Strain Constant d31 (10-10 m/V) | - | 1.74 |
Piezoelectric Strain Constant d33 (10-10 m/V) | - | 3.94 |
Piezoelectric Strain Constant d51 (10-10 m/V) | - | 5.35 |
Mechanical properties of host structure and piezoelectric patch
Thin steel plate with piezoelectric patches
This section presents design and implementation of the active vibration controller via piezoelectric actuators. At first, proportional feedback controller is presented and then analog implementation of the controller is explained.
Proportional feedback control is a very simple and easily implementable controller methodology. Since only a sensor signal is passed through a negative amplifier and fed back to the system, the total computational and implementation cost is very low. Thus, it is possible to apply this control scheme using analog circuits since it does not need online calculation of parameters such as controller gains and current states’ values. In addition to these, by using collocated sensor and actuator pair, proportional feedback controller provides active damping at the resonance frequencies of the structure. In fact, this active damping can be employed effectively in the lower-frequency modes of the structure because of stability issues. At the high-frequencies, the phase lag may deteriorate the stability of the collocation and the closed-loop system can be unstable. This high-frequency stability problem is eliminated usually by decreasing the proportional gain or including a low-pass filter in the closed-loop. In this paper, we consider a proportional velocity feedback controller along with a low-pass filter to eliminate high-frequency dynamics.
The undesired vibrations of the thin separation plate are originated by external disturbances and the controller is designed for the expected disturbances including frequencies up to the third resonance mode. By only aiming low-frequency vibration suppression of the plate, high frequency performance of the controller is not considered. For this purpose, a low pass filter which has a cut-off frequency around third resonance mode is considered. In order to have decay at the frequencies higher than the cut-off frequency, the filter is included as an input low-pass filter and is placed between the sensor signal and the controller.
Then, the amplifier gain is adjusted by utilizing the tools of Ziegler-Nichols method. In Ziegler-Nichols method, the important step is the determination of critical gain (gain margin of the closed-loop system). This critical gain is defined as the amplifier ratio at which response of the controlled plant has sustained oscillations and closed-loop system is at the stability limit. Proportional feedback criterion of Ziegler-Nichols method claims that 0.8 times the critical gain yields the best proportional controller performance.
Having determined the cut-off frequency of the filter and amplifier ratio, the proportional velocity feedback controller is finalized for the implementation and experiments.
The designed proportional velocity feedback controller is implemented on a breadboard by using the circuit shown in Fig. 6. This analog circuit includes one inverting amplifier and low-pass filter.
The measured sensor voltage signal (Vin) is passed through a low pass filter which is in the form of resistor-capacitor (RC) filter. The cut-off frequency of this filter equals to one divided by multiplication of resistor and capacitance value. The aim of this low-pass filter is the reduction of high-frequency components of the sensor signal. After passing through this filter, the filtered signal is fed to the inverting amplifier. This inverting amplifier includes an operational amplifier (op-amp) and two resistors as indicated in Fig. 6. The op-amp is powered by dual polarity. The filtered sensor voltage is connected through input resistor Rc to the positive input channel of the op-amp. Then, a jumper resistor Rf is included between positive input channel and the output channel, whereas negative input channel is connected to the ground. By passing through this inverting amplifier, the sign of filtered sensor signal is inverted and its voltage value is amplified. The amplifier ratio is equivalent the ratio of jumper resistor Rf and input resistor Rc. Finally, this amplified and inverted signal serves as the proportional controller output signal.
Implementation diagram for analog proportional velocity feedback controller
Experimental setup for active vibration and noise reduction
The experimental setup for active vibration control via analog velocity feedback controller is presented in Fig. 7 with the data acquisition system. The data acquisition system has the ability of generation and recording analog voltage signal while communicating with a PC through Ethernet connection. The system provides high frequency sampling with high measurement accuracy and also generates the disturbance signal to drive the shaker amplifier. The mechanical shaker is located in the left compartment in Fig.4, and attached to the thin-separation plate via a connecting rod and a force sensor. The vibration of this plate is measured by Polytech PDV100 laser Doppler vibrometer (LDV). The target location of the vibrometer is determined as the same point of the piezoelectric patch to obtain a collocated sensor and actuator pair. The voltage output of the LDV is connected to the analog controller as a sensor signal and sent to the data acquisition system for recording. By connecting the sensor signal to the analog circuit, the controller output signal is acquired. This controller signal is amplified by E-413 Dura-act Piezo Driver and sent to the PZT patches (Dura-act P876.A12). Control input voltage between -2V and +8V are accepted by the voltage amplifier and the input signal is amplified by factor of 50. By closing-the-controller loop, an active damping system for vibration suppression is created. While the vibration suppression experiments are conducted, the output signal of a microphone properly located in one of the compartments is also recorded at the same timeto demonstrate the suppression of noise.
In this section, active vibration suppression of the thin separation plate and noise reduction inside the compartment via analog velocity feedback controller is presented. The experimental results are given in frequency and time domains for three different piezoelectric patch configurations. At first, the piezoelectric patch located at center and upper-left is used as an actuator independently, and then they are employed together as an actuator.
The performance of the analog velocity feedback control for the vibration suppression is evaluated in the time domain by disturbing the thin separation plate with the mechanical shaker. For this purpose, disturbance signal is applied to the mechanical shaker via data acquisition unit as a sine-wave at the first resonance frequency (approximately 13 Hz) and at the second-resonance frequency (approximately 26 Hz) of the plate. The vibration of the plate is monitored by targeting laser displacement to the center of the piezoelectric actuator patch. The experiments are conducted for each piezoelectric actuator configuration. Fig. 8 presents the results for forced vibration at the first resonance frequency. Fig. 8 (a) presents the open-loop vibration at the center of the plate. The open-loop response corresponds to the structural vibrations of the thin plate when the analog feedback controller is inactive. Fig. 8(b) shows the closed-loop vibration response of the plate when the active vibration suppression is obtained via piezoelectric patch located at center. In Fig. 8(c), the piezoelectric patch located at upper-left and is employed as actuator independently. The Fig. 8(d) shows the closed-response for the piezoelectric actuator in pair configuration where the center and upper-left patch are used as actuator jointly and laser displacement sensor is targeted to the center of the upper-left patch.
As can be seen from the subfigures of Fig. 8, the vibration of the plate at the first resonance frequency is attenuated for each piezoelectric actuator configuration. In fact, the best performance is acquired when the piezoelectric center patch is used as actuator independently. The performance of this configuration is better than the pair configuration because of phase mismatch of the piezoelectric patches in pair. Fig. 8 presents the open and closed vibration of the plate for the second resonance forced vibration. To measure the open-loop vibrations of the plate, the LDV is targeted to the center of the upper-left patch. Fig. 9(a) presents the open-loop vibration measured at this location. Fig. 9(b) shows the performance of the active vibration control via piezoelectric actuator patch located at the upper-left of the plate. Besides, Fig. 9(c) presents the effectiveness of piezoelectric pair configuration for the vibration suppression of the plate.
Vibration response of the plate at the first resonance frequency (a) Open-loop (b) Closed-loop with piezoelectric patch located at center (c) Closed-loop with piezoelectric patch located at upper-left (d) Closed-loop with piezoelectric actuator patches in pair
Vibration response of the plate at the second resonance frequency (a) Open-loop (b) Closed-loop with piezoelectric patch located at upper-left (c) Closed-loop with piezoelectric actuator patches in pair
Piezoelectric Patch Configuration | LDV Target Location | First Mode | Second Mode |
Center | Center | 44.6% (5.1dB) | - |
Upper-left | Center | 20.4% (1.9 dB) | 73.8% (11.6 dB) |
Center and Upper-left (Pair Configuration) | Upper-left | 32.3% (3.4 dB) | 74.9% (11.9 dB) |
Vibration suppression levels in time domain for different piezoelectric actuator configurations
To employ piezoelectric patches in pair for the second resonance mode of the plate, the LDV is targeted again to the center of the upper-left piezoelectric patch. It is obvious that the independent configuration of piezoelectric patch located at upper-leftprovides better vibration suppression when it is compared with the pair configuration. The reduction levels for each configuration are presented in Table 2.
The aim of this section is to present the performance of the active vibration suppression in the frequency domain. The experiments are conducted for the same piezoelectric actuator configurations. In contrast to time-domain results, the disturbance signal applied to the mechanical shaker is changed to sine-sweep in the bandwidth of 2 Hz to 100 Hz. By monitoring the open-loop and closed-loop response of the plate, frequency responses are gathered using the data acquisition system. Fig. 10 presents the frequency responses for different piezoelectric configurations between vibrometer and the force transducer at the tip of the mechanical shaker. In Fig. 10(a), the performance of the active vibration suppression system via piezoelectric patch located at center is presented. It is noticeable that the vibration is attenuated very well in the first resonance mode of the plate; however the other resonance frequencies of the plate are not affected. This is due to the fact that the position of piezoelectric patch located at center corresponds to the anti-mode of the higher order modes. So, the higher structural modes are not affected. Fig. 10(b) presents the closed-loop performance of the piezoelectric patch located at upper-left. As can be seen this figure, the closed-loop system reduces the vibration of the plate in a broad frequency range for this configuration. Fig. 10(c) shows the effectiveness of the closed-loop system via piezoelectric actuator pair. It is noticeable that the performance of the closed-loop is improved considerably when piezoelectric pair configuration is adopted instead of using upper-left patch independently. Indeed, the closed-loop system reduces the vibration levels as compared to open-loop in all piezoelectric actuator configurations. Table 3 lists the vibration reduction levels in the frequency domain.
Frequency responses for different piezoelectric actuator configurations (a) Closed-loop with piezoelectric patch located at center(LDV at center) (b) Closed-loop with piezoelectric patch located at upper-left(LDV at upper-left) (c) Closed-loop with piezoelectric actuator patches in pair(LDV at upper-left)
Piezoelectric Patch Configuration | LDV Target Location | First Mode | Second Mode |
Center | Center | 63.7 % (8.8 dB) | - |
Upper-left | Center | 34.1 % (4.4 dB) | 52.8 % (6.5 dB) |
Center and Upper-left (Pair Configuration) | Upper-left | 50.6 % (6.1 dB) | 54.0 % (6.7 dB) |
Vibration suppression levels in time domain for different piezoelectric actuator configurations
This section presents the noise reduction in one of the compartments for controller-inactive and active cases while disturbing the thin plate via shaker. The noise inside the compartment is measured with a microphone. The frequency responses between the microphone and the force transducer are gathered using the data acquisition system. Fig. 11presents the results for noise in the frequency domain. As in the same manner with vibration suppression experiments, open-loop response shows the noise radiation in the compartment when the controller is inactive, whereas closed-loop response is monitored when the controller is active. In Fig. 11(a), the performance of noise reduction via piezoelectric patch located at center is given. It is noticeable that the low-frequency acoustic mode in the compartment coincides with the vibration mode of the plate. Since the vibration of plate at the first resonance mode is considerably attenuated, the noise radiation is also reduced for this mode. At the higher-acoustics modes, the closed-loop system does not improve and deteriorate the noise radiation in the compartment. Fig. 11(b) presents the effectiveness of the piezoelectric patch located at upper-left. Similar to the previous results, noise radiation is reduced by suppressing the vibration of the plate. However, it is obvious that the performance of the piezoelectric patch located at center is fairly better than the performance of the piezoelectric patch located at upper-left.
Noise levels in the one of the compartments for different piezoelectric patch configurations (a) Open and closed-response for the piezoelectric patch located at center (b) Open and closed-loop response for the piezoelectric patch located at upper-left
In the first part of this chapter, a short review of literature about active vibration control is presented.The general controller design approach and the differences between various controller algorithms are discussed.
In the second part of this chapter, an application using an analog velocity feedback controller for vibration suppression of a flexible plate is presented. Experiments for vibration suppression of the flexible plate are conducted and by measured the vibration of the plate; the time-responses and frequency-responses are presented. Finally, the acoustic response in one of the compartments is also obtained for different piezoelectric actuator configurations. The results revealed that vibration reduction of the separation plate improves the noise radiation and the sound pressure level is decreased due to the reduction of the vibration. However, for an effective and powerful noise reduction, robust controller algorithms with multiple piezoelectric actuator patches can be preferred.
The great journey of building rational scientific knowledge includes observing, making conjectures, and severely verifying them for flaws, limitations, and errors. When conjectures falter, scientists revisit, revise, abandon, start afresh, search for alternatives, etc. They seek unity in diversity or generalize to include diversity, with the knowledge that “truth” is not knowable. In this journey, they seek to be rational, parsimonious1 in making conjectures, and methodical, open, transparent, and consistent when sharing them. Conjectures are deemed scientifically valid only if there is potential scope of finding an error [1]. “Though [a mistake] stresses our fallibility it does not resign itself to scepticism, for it also stresses the fact that knowledge can grow, and that science can progress—just because we can learn from our mistakes” [1]. The process is criticism controlled.
\nIn the last few decades, technology has provided some remarkable tools to accelerate, not merely speed up, this process, and these tools have tremendous potential of becoming even more versatile. In the context of synthetic biology, the tools include the triad: clustered regularly interspaced short palindromic repeats (CRISPR) gene editing technology in genetic engineering, artificial intelligence (AI), and quantum computing (QC). There is also a torrential gathering of data since the Human Genome Project [2] published a draft sequence and initial analysis of the human genome in February 2001 [3]. The new sources include data flowing from the Human Cell Atlas project, which plans to identify and locate every type of cell we possess [4], and various brain projects initiated in the US, Europe, Japan, and Korea, and privately funded Allen Institute for Brain Science. China and Taiwan are also getting in the fray [5]. To make sense of the growing mountains of data in terms of finding “the molecular logic of the living state” in a timely manner rather than drowning in it will require data curation and analysis tools and resources that presently only CRISPR, AI, and QC can provide. This appears fortuitous since we anticipate a catastrophic speciation of the
This chapter is therefore written for the millennials on whose shoulders will fall the responsibility of navigating through a socioeconomic epochal change that is already under way—the emerging postindustrial era—and a possibly unanticipated speciation of the
Biology is a game of creation, survival by adaptation, and annihilation; it is a game that is “red in tooth and claw”. Survival of the fittest (also called natural selection) means survival of those best able to adapt to the environment they are in. This is not about individual survival but of cohesive groups belonging to a species capable of exchanging genes or interbreeding. Natural selection is an ultraslow process in which sudden, dramatic changes in the environment generally mean sudden decimation of species living in it.
(Left) World population growth. (Right) World population growth, 1950–2050. Source:
With the benefit of hindsight, we can discern the heralding signs of speciation that went unnoticed. In the rapidly growing global population (presently at 7.7 billion plus), the collective population of the more developed countries (characterized by high living standards and education, and low birth rate) since the last several decades has stabilized to about 1.3 billion (including immigrants), while that of the less developed countries (with opposite characteristics) is steadily rising. Concurrently, globally wealth has concentrated into fewer and fewer hands. In January 2018, Oxfam reported that “82% of all wealth created in the last year went to the top 1%, and nothing went to the bottom 50%”, that the wealthiest 42 people now had as much wealth as the poorest half, and two-thirds of billionaires wealth come from inheritance, monopoly, and cronyism [7, 8]. The environment for the poorest (hence unfittest) is already brutal.
\nWhen natural speciation starts, its largest and earliest victims will come from the less developed countries before it hits the developed ones. In this respect, Africa appears to be highly vulnerable; it “has become the source of some of the greatest threats to the global economic order. Rather than capitalizing on opportunities, international engagement is increasingly focused on mitigating risks” [9]. When speciation begins, these risk mitigation efforts will be in vain because it is the global socioeconomic structure itself that will be disintegrating. The
Speciation is about adapting to the environment.
Kurzweil also forecasts that the future will provide opportunities of unparalleled human-machine synthesis:
\nKurzweil’s forecasts are based on his “law of accelerating returns” that enunciates that fundamental measures of information technology follow predictable and exponential trajectories seemingly unaffected by dramatic socioeconomic events such as war or peace, and prosperity or recession, paralleling Moore’s law in computer technology—the number of transistors on integrated circuit chips doubles approximately almost every 2 years. Indeed, it turns out that once a technology becomes
During the industrial era just behind us, most people reached their peak capacity to educate and skill themselves in activities (including earning a living) that required mechanizable “intelligent” rote education. That AI machines, in principle, can far surpass humans in such activities had become evident when Alan Turing showed how arithmetical calculations can be mechanized [12] and Gödel had earlier shown that any axiomatic system can be arithmetized [13]. This meant that any form of rational knowledge could be axiomatized and rote education programmed into computers. While creating new knowledge would still require human creativity, once that knowledge had matured and was formalized into an axiomatic system, it would be mechanizable and expandable. It would then be a matter of time that humans would increasingly face competition from machines and eventually be overwhelmed by them. Kurzweil’s prediction that this would happen during 2029–2045 is bolstered by recent advances in AI. Ongoing advances in deep learning by machines indicate that through self-learning they can become highly creative and creators of original technology (the patent system will go for a toss) and scientific discoveries without human intervention may well become the norm [14]. Of some 150 predictions since the 1990s, Kurzweil claims an 86% accuracy rate [11, 15, 16]. Since synthetic biology has now come under the grip of mathematics, its exponential development is certain. Synthetic biology is now a part of information technology.
\nIt is only in the last few years that the enormous significance of the exponential growth property of the law of accelerating returns has sunk in the minds of people. As one can see from Figure 2 (left), till one reaches the vicinity of the knee of the curve, the curve looks deceptively linear with a mild slope. This allows human minds to extrapolate into the future from gathered knowledge and experience. At the knee, the curve bends upward so rapidly that the human mind cannot respond fast enough to absorb, assess, contemplate, and react rationally. Knee-jerk reaction is about the best humans are capable of in such a situation.
Exponential growth. Source: (top left) Author. Nature of exponential growth. (Top right) Steve Jurvetson. An updated version of Moore’s Law (based on Kurzweil’s graph). Wikimedia Commons.
Once AI breaches a certain threshold, one should expect a runaway technological growth resulting in a phase transition in human civilization, including perhaps the speciation of the
Exponential growth in AI has advanced the possibility that artificially induced speciation of
The language of information now pervades molecular biology—genes are linear sequences of bases (like letters of an alphabet) that carry information (like words) to produce proteins (like sentences). For the process of going from DNA sequences to proteins, we use words like “transcription” and “translation,” and of passing genetic “information” from one generation to another. It is rather uncanny that molecular biology can be understood by ignoring chemistry and treating the DNA as a computer program (with enough input data included) in stored memory residing in a computer (the cellular machinery). It is this aspect that bioinformatics exploits. It is analogous to viewing Euclidean geometry not in terms of drawings but in terms of algebra.
\nIn a sense, in the DNA sequences in our cells, written using an alphabet of only four letters, lies hidden the story of who we are and where we come from. For all we know, it might even tell us where we might be going. Albert Lehninger wrote:
\nIt is this “molecular logic of the living state” that is yet to be completely understood, and therein may lie our ability to understand emotion, cognition, and intelligence. So, in a deep sense, the DNA is the master molecule of life. A marvelous thing about cells is that they are so designed that for many purposes one can totally ignore their chemistry and think just about their logic. The fact that one can get away with this is one of the most elegant aspects of molecular biology. The algorithmic side of molecular biology is bioinformatics, the study of information flows in living matter. Bioinformatics is about the development and application of algorithms and methods to turn biological data into knowledge of biological systems. Of fundamental interest is the organization and control of genes in the DNA sequence, the identification of transcriptional units in the DNA, the prediction of protein structure from sequence, and the analysis of molecular function. If there is mathematical logic in living things, then one naturally seeks to determine the formal mathematical system that governs life, that is, how information in the DNA is stored and used by the rest of the cell’s machinery to do the myriad of things that it does.
\nWe already know that a DNA molecule—a genotype—is converted into a physical organism—a phenotype—by a very complex process, involving the manufacture of proteins, the replication of the DNA, the replication of cells, the gradual differentiation of cell types, and so on. This epigenetic process is guided by a set of enormously complex cycles of chemical reactions and feedback loops. By the time the full organism appears, there is no discernible similarity between the physical characteristics of the organism and its genotype. Yet molecular biologists attribute the physical structure of the organism to the information encoded in its DNA, and to that alone. This is because there is overwhelming experimental evidence that only DNA transmits hereditary properties. The genotype and the phenotype are isomorphic. However, this isomorphism is so complex that so far it has not been possible to divide the phenotype and genotype into parts, which can be mapped onto each other directly, unlike as, say, in the case of a music record and a record player where portions of a record’s track can be easily mapped to specific musical notes [20]. One hopes that AI and QC together will enable us to find this complex mapping. It is all about information processing.
\nBy information we mean the precise determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein. We gain knowledge of biological systems when we can interpret information in some “meaningful” way without it being easily refuted. That is, we make conjectures and put them through rigorous tests of refutations. Molecular biologists are becoming increasingly sure that “life is a partnership between genes and mathematics” [21]. Indeed, we increasingly tend to believe as Max Tegmark does about the Universe itself:
\nOne can well imagine the enormous strides synthetic biology will make when researchers get a deeper understanding of the Book of Life, with AI software becoming their research assistant, and quantum computers executing all the computing required by the AI software.
\nThe time has come for synthetic biology, AI, and QC to join hands and form a purposeful, integrated discipline to further explore the secrets of life, create new life, and find harmonious ways by which
Mathematics is the
Creating and advancing rational knowledge,
Both AI and QC are inseparable from mathematics; they are powerful means of processing and interpreting information (e.g., in the DNA) as well as aiding in inventing novel DNA for specific purposes. Both support and are supported by 3D printing that began by making plastic widgets, but now make guns, houses, prosthetic limbs, vehicle parts, etc. from inanimate matter. The day is not far off when it will advance to printing living, breathing, bio-organs, such as hearts [26] and kidneys, using nanotechnology, computer-aided engineering, and inanimate biodegradable or biocompatible materials and chemicals to build stem cells. Replicating and growing cells, say, in petri dishes is well established, and such cells are already in use as bioink in bioprinters. 3D printing offers the possibility of printing an entire organ, along with a system of arteries, capillaries, and veins that can support it [27, 28]. A major issue in developing this technology is to make it immune-system friendly, since the body may reject organs or cells thus produced, something that can occur even when tissue from one area of the body is put into another.
\nCRISPR technology has enabled a simple and affordable method of manipulating and editing DNA that has radically changed the ambitions of synthetic biologists. The technology promises to revolutionize how
CRISPR is a series of short repeating DNA sequences with “spacers” separating them. The CRISPR technology harnesses an ancient bacteria-based defense system. Bacteria use these genetic sequences to “remember” the viruses that have attacked them by the simple mechanism of incorporating the virus’ DNA into their own bacterial genome. The viral DNA thus resides as spacers in the CRISPR sequence as identification tags the bacteria can use to mount an attack if the virus attacks again. Accompanying the CRISPR are locally stationed genes called Cas (
The ability to cut DNA allows one to either knock out, say, an unwanted disease-causing gene, or splice a “fixed” version of a gene into the DNA. This is analogous to the “Find & Replace” function in text editing software. Indeed, CRISPR technology has advanced so rapidly beyond the Find & Replace function that by December 2017, the Salk Institute had designed a version of the CRISPR-Cas9 system that could switch on or off a targeted gene without even editing the gene. The basic ingredients of gene editing are (1) a piece of RNA, called the guide RNA, that locates the targeted gene, (2) the scissors (the CRISPR-associated protein 9), and (3) the desired DNA segment for insertion after the break. Once the guide RNA locates the targeted gene, Cas9 makes a double-stranded break in the DNA carrying the targeted gene and replaces it with the desired DNA segment. A quick tutorial on CRISPR is available at [29].
\nCRISPR-based therapies are still nascent. As expected, single-gene disorders are among the best understood because of their simple inheritance patterns (recessive or dominant) and relatively simple genetic etiology (cause). Such disorders include cystic fibrosis, hemochromatosis, Tay-Sachs, and sickle cell anemia. For example, cure for sickle cell disease (an inherited form of anemia in which distorted red blood cells—rigid, sticky, and shaped like sickles—are present in such numbers as to prevent adequate oxygen supply throughout the body) has gained prominence because it is related to an abnormal hemoglobin molecule, which comes from a well-understood genetic mutation. Hence efforts are concentrated on creating therapeutic strategies for fixing the mutated gene. Online Mendelian Inheritance in Man® (OMIM®) provides an Online Catalog of Human Genes and Genetic Disorders, a comprehensive database provides information about the etiology, clinical symptoms, and a bibliography of thousands of genetic conditions.4
\nThis behavior is a product of the brain-mind system an individual is born with and the environment it finds itself in. From conception to death, behavior and intelligence evolve through intimate interaction between the individual and the environment where the individual essentially tries to coexist with the environment by exploring networking strategies,
It is this scientific knowledge ferreted out by a few geniuses among the
Big data revolution, development and deployment of wearable medical devices, and mobile health applications have provided new powerful tools to the biomedical community for applying AI and machine learning algorithms to vast amount of data. Its impact in predictive analytics, precision medicine, virtual diagnosis, patient monitoring, and drug discovery and delivery is already being felt. More powerful advances are anticipated in the near future. Even at this early stage, AI excels even human experts in certain well but narrowly defined tasks. AI is at a stage where basic building blocks are being built. Soon we will learn to network these blocks and build increasingly powerful systems and subsystems that will solve increasingly complex problems and even create new knowledge. We already have a glimpse of it in Alphabet’s AlphaGo Zero’s ability to learn complex decision-making from scratch [33, 34]. “Previous versions of AlphaGo initially trained on thousands of human amateur and professional games to learn how to play Go. AlphaGo Zero skips this step and learns to play simply by playing games against itself, starting from completely random play. In doing so, it quickly surpassed human level of play and defeated the previously published champion-defeating version of AlphaGo by 100 games to 0” [34]. It acquired this ability within 40 days of self-training in an essentially iterative manner. The key here is the iterative strategy it used. Indeed,
Notwithstanding AlphaGo’s success, many real-life problems are still far too difficult not just for current AI systems but also for the vast-vast majority of
The solution to eliminating manual labor may well be the creation of an artificial brain using synthetic biology. For the present, AI serves mainly by “augmenting human intelligence”. But then automation too had begun by augmenting brawn (muscle) power to eventually become the superbrawn power during the industrial revolution. It only required the
Quantum mechanics deals with the world inhabited by photons, electrons, protons, atoms, molecules, etc. and how they interact among themselves to create larger matter entities. It is an incredibly mysterious world understood only in the language of advanced mathematics. This is the part of physics that tells us how atoms congregate into molecules by adjusting the electrons they carry into configurations that we call chemical bonds, how strong or weak those bonds will be or whether they will bond at all, what a congregation’s physical and chemical properties will be. It has led to many technical innovations and many more are expected, for example, in synthetic biology. The success of quantum mechanics in using mathematical abstractions is such that to a lay person it appears mystical, which even religious mystics cannot understand! Its remarkable success comes even though we still do not know what is meant by measurement in the quantum world and how the measurement process captures the information it outputs and why it releases information in a randomized way. Yet its success is undeniably visible:
\nUnderstanding quantum mechanics is out of reach except for a few thousand people in the world at any given time! This should immediately alert us to the fact that human intelligence needed to cope with AI-QC combination in the future will be very high and successor species of the
Computing technology has now advanced to a stage where quantum computers can do everything that a UTM can do, and some more. A quantum computer’s phenomenal computing power comes from the extraordinary laws of quantum mechanics that include such esoteric concepts as superposition of quantum states, entanglement (“spooky action at a distance”), and tunneling through insulating walls, which, though highly counterintuitive, play extremely useful roles in understanding Nature at subatomic levels. However, it is not clear if these concepts can be ignored in biology and living processes in the way they are ignored in the design of cars and airplanes. May be not because there are areas in biology where quantum effects have been found, for example, in protein-pigment (or ligand) complex systems [40]. Thus, while the role of quantum mechanics is clear in quantum computing and hence in advancing both AI and synthetic biology research, it is not yet known if in the design of DNA, knowledge of quantum mechanics is required or that natural selection favors quantum-optimized processes. Essentially, we do not know if any cellular DNA maintains or can maintain sustained entangled quantum states between different parts of the DNA (even if it involves only atoms in a nucleotide). But we cannot rule out the possibility that sporadic random entanglements do occur that result in biological mutations or that researchers will not be able to achieve it in the laboratory and find novel uses for it in synthetic biology [41]. For example, in principle, it is possible to design molecular quantum computers, insert them in cells that can observe cellular activity, and activate select chemical pathways in the cell in a programmed manner. There is increasing speculation that some brain activity, for example, cognition, may be quantum mechanical [42].
\nA combination of emerging technologies such as CRISPR, AI, and QC; new delivery models for products and services that form the core around which
Synthetic biology, using methods and rational knowledge of molecular biology, physical sciences, and engineering, aims to design and construct novel biological parts, artificial biological pathways, devices, organisms, and systems for useful purposes. This will also permit us, at all levels of the hierarchy of biological structures (molecules, cells, tissues, and organisms), to redesign existing natural biological systems and may even help us recreate certain extinct species (if we can also recreate the environment, they had adapted to). It is not surprising that an extinct species has never revived itself since speciation and environment go together. Successes of synthetic biology will change the face of human civilization and almost certainly bring in new elements into play when
Since the discovery of the double-helix structure of cellular DNA by James Watson and Francis Crick in 1953 [43] and its significance that the “precise sequence of the bases is the
Just 20 years after Watson and Crick, in 1973 Cohen and Boyer published their pioneering work in recombinant DNA [45] and gave birth to genetic engineering and the biotechnology industry based on their patents [46] under liberal licensing terms. The next landmark was the creation of a bacterial cell controlled by a chemically synthesized genome by Craig Venter and his group in 2010 [47]. In 2014, Floyd Romesberg and colleagues [48] reported the creation of a semisynthetic organism with an expanded genetic alphabet by creating artificial nucleotides not found in Nature. Since its discovery in 2012 [49, 50, 51], CRISPR gene editing technology pioneered by Jennifer Doudna and Emmanuelle Charpentier, and Feng Zhang has come to occupy center stage in molecular biology as a new way of making precise, targeted changes to the genome of a cell or an organism. It has set the stage for major advances in synthetic biology (see Section 4.1). Another major advance was reported by Venter and his research group in March 2016 following their successful creation in 2010 of a bacterial cell controlled by a chemically synthesized genome noted above. In fact, they succeeded in creating a bacterium that contains the minimal genetic ingredients needed for free living. The genome of this bacterium consists of only 473 genes, including 149 whose precise biological function is unknown. It is a minimalist version of the genome of Mycoplasma mycoides [52, 53].
\nSynthesis capabilities have developed at a pace where DNA synthesis is now automated. All one needs to do is to provide the desired DNA sequence to a vendor. Researchers in synthetic biology are now inching toward anticipating and preempting evolutionary events that if left to themselves would perhaps take a few million years to occur, and of even resurrecting extinct species. The time is ripe to integrate synthetic biology with AI and QC with a common language to enable seamless communication among them, connect with, and discover conceptual similarities for consistent integration of subsystems and validation of the whole system. That common language is mathematics; it comes with the added benefit that it can be used to also communicate between humans and machines. It is fortuitous that the DNA serves as the “Book of Life” that appears to have structure and grammar amenable to translation into mathematics. Once translated, biologists will discover some amazing patterns that have a direct bearing on life at the molecular level. We introduce a few of these below in brief.
\nAll macromolecules are constructed from a few simple compounds comprising a few atoms. It appears paradoxical that the DNA that serves as the epitome of life is itself lifeless. The molecule conforms to all the physical and chemical laws that describe the behavior of inanimate matter. All living organisms extract, transform, and use energy by interacting with the environment. Unlike inanimate matter, a living cell has the unique capacity, using the genetic information contained completely within itself, to grow and maintain itself and do mechanical, chemical, osmotic, and other types of work. But its most unique attribute is its programmed capacity to self-replicate and self-assemble. The great mystery that engulfs molecular biology is: “How does life emerge from an interacting collection of inanimate molecules that constitute living organisms to maintain and perpetuate life?” Once this is understood, chemical engineers will create a new life industry and commoditize it! Imagine buying customized pets as starters.
\nAs noted in Section 3, the mystery of life is almost certainly encoded in mathematics. The chemical basis of life is one indication because chemistry now has a strong mathematical foundation via quantum chemistry. Even more striking is the fact that all living organisms—bacterium, fish, plant, bird, animal—share common basic chemical features, for example, the same basic structural unit (the cell), the same kind of macromolecules (DNA, RNA (ribonucleic acids), and proteins) built from the same kind of monomeric subunits (nucleotides and amino acids), the same pathways for synthesis of cellular components, the same genetic code, and evolutionary ancestors. The monomeric subunits can be covalently linked in a virtually limitless variety of sequences just as the 26 letters of the English alphabet or the two binary numbers (0, 1) in binary arithmetic can be arranged into a limitless number of strings that stand for words, sentences, books, computer programs, etc.
\nOrganic compounds of molecular weight less than about 500, such as amino acids, nucleotides, and monosaccharides, serve as monomeric subunits of proteins, nucleic acids, and polysaccharides, respectively. A protein molecule may have a thousand or more amino acids linked in a chain, and DNA typically has millions of nucleotides arranged in sequence. Only a small number of chemical elements from the periodic table of chemistry appear in biomolecules. The carbon atom dominates and, by virtue of its special covalent bonding properties, permits the formation of a wide variety of molecules by bonding with itself, and atoms of hydrogen, oxygen, nitrogen, etc. Nature has placed further constraints. DNA is constructed from only four different kinds of subunits, the deoxyribonucleotides; the RNA is composed from just four types of ribonucleotides; and proteins are put together using 20 different kinds of amino acids. The 8 kinds of nucleotides (4 for DNA and 4 for RNA) from which all nucleic acids are built and the 20 amino acids from which all proteins are built are identical in all living organisms. So, at this level, living organisms are remarkably alike in their chemical makeup. This by itself provides a tantalizing hope that the DNA may indeed be completely decipherable as to its grammar and information content.
\nThe above observations strongly suggest the likelihood of an underlying, as yet undiscovered set of “axioms” of life that enforce emergent, organizing principles around which diverse life forms evolve and adapt to the environment at various levels, without transgressing any physical or chemical law. The organizing principles appear to include (1) Nature is red in tooth and claw (species are connected to each other in a predator-prey, food-chain relationship in a sparse resource matrix), (2) rules of genetic inheritance, (3) rules of environmental adaptation, and (4) rules of speciation. At each level, the rules are likely to appear stochastic given that there are innumerable interacting factors ranging from nature to nurture.
\nIn 1960, Erdős and Rényi [54, 55] proved a remarkable result in graph theory, which implies that when a large number of entities (e.g., men, machines, ideas, or arbitrary combinations of them represented by dots) begin to connect (link) randomly, a critical condition arises, following which a phase transition occurs in the way the entities form or reform into clusters of connected entities. The critical condition is reached when in a set of
Synthetic biologists must never forget that between the molecular and environmental levels, there are multiple intermediate levels through which regulated command and control communications pass. At all levels, level-related phase transitions and predatory fights for resources can occur and spread to other levels. In fact, the intimately coupled relationship between
The deep significance of this intimate bonding between the
Rapidly increasing connectivity among men and machines has imposed upon the global socio-politico-economic structure, a series of issue-dependent phase transitions. More will occur in areas where massive connectivity is in the offing. Immediately before a transition, existing man-made laws begin to crack, and in the transition, they break down. Posttransition, new laws must be framed and enforced to establish order. Since such a phase transition is a statistical phenomenon, the only viable way of managing it is to manage groups by abbreviating individual rights. The emergence of strongman style of leadership and its contagious spreading across the world is thus to be expected because job-seeking millennials will expect them to destroy the past and create a new future over the rubble. It appears inevitable that many humans will perish during the transition for lack of jobs or their inability to adapt to new circumstances. Robots and humanoids will gain domination over main job clusters, while society undergoes radical structural changes. Ironically, robots neither need jobs, nor job satisfaction, nor a livelihood. There will be ruthlessness in the reorganization.
\nConsider the iteration
The logistic map.
There are countless situations for which the logistic map captures the essence of a situation. For example, in genetics it describes the change in gene frequency in time, or in epidemiology the fraction of the population infected at time
Now consider the following complex iteration. Given the complex variable
Mandelbrot set.
In 1981–1982, Adrien Douady and John H. Hubbard [58] proved that the Mandelbrot set is connected. Quite astoundingly, the Mandelbrot set, when magnified enough, is seen to contain rough copies of itself, tiny bug-like objects (molecules) floating off from the main body, but no matter how great the magnification, none of these molecules exactly match any other (see Figure 5 and follow the white-bordered square from left to right). The boundary of
Infinite variations of the Mandelbrot set are embedded in the set itself. Source: Ishaan Gulrajani, A zoom sequence of the Mandelbrot set showing quasi-self-similarity, 01 October 2011,
Since the logistic map and the Mandelbrot set map quadratic functions, and both represent behavior under iteration, it is not surprising that a one-to-one correspondence exists between the constants
(Left) Connection between the logistic map and the Mandelbrot set. (Public domain) Source: Georg-Johann Lay, 07 April 2008, at
It appears that the Mandelbrot set,
The pace at which a system is driven through cyclic (iterative, also called self-referential) processes, that is, cycles of construction and destruction constrained by recyclable finite resources, has a profound effect on how the system evolves. A remarkably simple model as the logistic map shows an amazing variety of nonintuitive dynamics that a nonlinear system can display. It too provides a basic involuntary mechanism by which a society spontaneously reorganizes itself. In his seminal paper on the logistic map, Robert May, a theoretical ecologist and former President of the Royal Society (2000–2005) was so struck by the deep relationship between complexity and stability in natural communities that he exhorted:
\nWhat lessons can we draw from such simple mathematical models? For one, the logistic map indicates that the Earth’s supply chain (the environment) has been grossly disrupted. In this predator-prey game where some
In the present global environment, saturated by connectivity between humans, machines, and ideas, the largest component emerging in any socioeconomic context is populated by the deprived who cannot fend for themselves.
In the absence of irreversible ecological damage, it is possible that, in the early stages, replenishment may happen by itself since Nature would have decimated a large component of the population from the less developed countries, thus presenting the survivors with a sudden increase in per capita resources. We may infer by analogy from the Mandelbrot set that once a new species survives long enough to avoid extinction (because it begins with a small population, which needs time to grow into adulthood), even if it is in some remote fringes of the set, it will likely someday reach the main (central) part of the set since the set is connected. Once this happens, the new species will likely continue for a very long time until it is decimated by the Sun entering its dying phase by turning into a giant red star. That will be a few billion years hence.
\nThe way we acquire knowledge is iterative and nonlinear—we conjecture and put our conjectures on trial, that is, put them to severe critical tests (refutations). As the trial progresses, we edit, discard, refine, and add to our conjectures in a pseudorandom manner controlled by criticism, driven by instinct, hunches, inspiration, etc. Conjectures and refutations in scientific research are deemed self- and community-driven adversarial processes. We connect the dots. At every step of linking the dots, we consult the axioms (conjectures) and the rules for deriving conclusions (theorems) to ensure that we are within the axiomatic system we have put on trial. This means that the process leads us to understand the Universe solely based on our chosen beliefs (axiomatic system).
\nAs far as we can tell, creating an axiomatic system is a nonmathematical and a highly intelligent act. Developing a sequence of theorems with a specific nontrivial goal in mind (developing algorithms) is also a highly intelligent act. However, executing an algorithm, once developed, can be mechanized and does not require intelligence, in fact, none at all. If the most useful aspect of intelligence is algorithmic, then it must be mechanizable and converted into computation. We believe the DNA is a book of knowledge about the birth and death of life. In principle, it is in machine-readable form. AI and quantum computing are the most powerful tools we presently have to decipher it. When AI drives our lives, it is the algorithm that really drives us.
\nSome recent bold experiments using CRISPR gene editing have provided glimpses of DNA editing as a new source of creating a variety of biomatter and life forms. For example, experiments are in progress for producing meat (beef, pork, poultry, and sea food) without killing animals by growing meat in the laboratory from cultured stem cells by multiplying them dramatically and allowing them to differentiate into primitive fibers that then bulk up to form muscle tissue. This would substantially reduce environmental costs of meat production and eliminate much of the cruel and unethical treatment of animals [62]. Another example is producing offsprings from same-sex mice parents, again using stem cells and CRISPR gene editing technology [63].
\nIn another development, till recently it was believed that mitochondrion DNA (mtDNA) in nearly all mammals (including humans) is inherited exclusively from the mother. However, recently, Luo et al. [64] have uncovered multiple instances of biparental inheritance of mtDNA “spanning three unrelated multiple generation families, a result confirmed by independent sequencing across multiple unrelated laboratories with different methodologies. Surprisingly, this pattern of inheritance appears to be determined in an autosomal dominant like manner.” Given that the mitochondrion is an energy-producing organelle in the cell, this discovery will have profound implications in synthetic biology and in the design of new drugs.
\nOnce humans master the art of designing DNA for self-replicating, multicellular organisms (we already know how to design cells not found in Nature and edit DNA), they will create living species of their own design. We also anticipate that when AI machines master the art of learning from mistakes (i.e., the art of making conjectures and refuting them in a spiraling process toward better knowledge, a possibility that mathematically exists), they would have taught themselves how to handily beat humans in intelligent activities and thereby break the human monopoly on intelligence. The seeds of this were sown when the AI program called AlphaGo decisively defeated the world’s greatest Go players in 2016 [65, 66]. AlphaGo has achieved what many scientific researchers had dreamed of achieving. It means that a machine can teach itself in a tiny fraction of the time it takes humans to explore
So, what comes after
The stage appears set for some remarkable advances in synthetic biology including artificial speciation as an alternative to the natural evolution of species.
We, the
The raw physical limitations of the
Modern computers have made increasingly powerful and compute intensive mathematical algorithms accessible to even those not trained in science and mathematics for solving complex problems. Rapid advances in artificial intelligence (AI) and quantum computing show an inevitable trend that a vast array of human activities that till now required intelligent
We therefore anticipate a forced speciation of the
Rapidly advancing research in the life sciences, while promising tools to meet global challenges in health, agriculture, the environment, and economic development, some of which are already on the horizon, also raises the specter of new social, ethical, legal, and security challenges. These include the development of ethical principles for human genome editing, establishment of regulatory systems for the safe conduct of field trials of gene drive-modified organisms, and many others. Additional concerns arise since the knowledge, tools, and techniques resulting from such research could easily lead to the development of bioweapons, facilitate bioterrorism, and the extinction of the
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Implications for parent education and prevention of risks for early and excessive exposure to digital technologies are discussed.",book:{id:"9043",slug:"parenting-studies-by-an-ecocultural-and-transactional-perspective",title:"Parenting",fullTitle:"Parenting - Studies by an Ecocultural and Transactional Perspective"},signatures:"Loredana Benedetto and Massimo Ingrassia",authors:[{id:"193200",title:"Prof.",name:"Loredana",middleName:null,surname:"Benedetto",slug:"loredana-benedetto",fullName:"Loredana Benedetto"},{id:"193901",title:"Prof.",name:"Massimo",middleName:null,surname:"Ingrassia",slug:"massimo-ingrassia",fullName:"Massimo Ingrassia"}]},{id:"45773",doi:"10.5772/57003",title:"Cultural Variations in Parenting Styles in the Majority World Evidences from Nigeria and Cameroon",slug:"cultural-variations-in-parenting-styles-in-the-majority-world-evidences-from-nigeria-and-cameroon",totalDownloads:5104,totalCrossrefCites:0,totalDimensionsCites:9,abstract:null,book:{id:"3440",slug:"parenting-in-south-american-and-african-contexts",title:"Parenting in South American and African Contexts",fullTitle:"Parenting in South American and African Contexts"},signatures:"Esther F. Akinsola",authors:[{id:"160225",title:"Dr.",name:"Esther",middleName:"Foluke",surname:"Akinsola",slug:"esther-akinsola",fullName:"Esther Akinsola"}]},{id:"45934",doi:"10.5772/57083",title:"Brazilian Mothers’ Cultural Models: Socialization for Autonomy and Relatedness",slug:"brazilian-mothers-cultural-models-socialization-for-autonomy-and-relatedness",totalDownloads:1703,totalCrossrefCites:2,totalDimensionsCites:8,abstract:null,book:{id:"3440",slug:"parenting-in-south-american-and-african-contexts",title:"Parenting in South American and African Contexts",fullTitle:"Parenting in South American and African Contexts"},signatures:"Maria Lucia Seidl-de-Moura, Rafael Vera Cruz de Carvalho and\nMauro Luís Vieira",authors:[{id:"108479",title:"Dr.",name:"Maria Lucia",middleName:null,surname:"Seidl-De-Moura",slug:"maria-lucia-seidl-de-moura",fullName:"Maria Lucia Seidl-De-Moura"}]},{id:"45939",doi:"10.5772/57242",title:"Child-Rearing Practices of Brazilian Mothers and Fathers: Predictors and Impact on Child Development",slug:"child-rearing-practices-of-brazilian-mothers-and-fathers-predictors-and-impact-on-child-development",totalDownloads:2992,totalCrossrefCites:1,totalDimensionsCites:4,abstract:null,book:{id:"3440",slug:"parenting-in-south-american-and-african-contexts",title:"Parenting in South American and African Contexts",fullTitle:"Parenting in South American and African Contexts"},signatures:"Cesar Augusto Piccinini, Patricia Alvarenga and Angela Helena\nMarin",authors:[{id:"161058",title:"Dr.",name:"Cesar",middleName:null,surname:"Piccinini",slug:"cesar-piccinini",fullName:"Cesar Piccinini"}]}],mostDownloadedChaptersLast30Days:[{id:"72249",title:"Digital Parenting: Raising and Protecting Children in Media World",slug:"digital-parenting-raising-and-protecting-children-in-media-world",totalDownloads:1623,totalCrossrefCites:4,totalDimensionsCites:10,abstract:"Digital media have quickly changed ways in which parents and children communicate, enjoy themselves, acquire information, and solve problems daily (both in ordinary and exceptional circumstances such as COVID-19 home confinement). Very young children are regular users of smartphones and tablet, so their early digital engagement poses new challenges to parent-child relationships and parental role. First, the chapter introduces the “digital parenting” construct, moving through the literature from “traditional” parenting styles to more recent studies on “parental mediation,” that is, the different behaviors parents adopt to regulate children’s engagement with the Internet and digital media. Second, the chapter reviews empirical researches on different parental mediation practices (active or restrictive behaviors) and how they are adjusted according to the child’s characteristics (age, digital competences, etc.) or parent’s media competence and beliefs. Finally, from a bidirectional perspective of parent-child relationships, the chapter discusses the role of youths’ social involvement, communication, self-disclosure, and digital skills on parent’s beliefs and practices. Implications for parent education and prevention of risks for early and excessive exposure to digital technologies are discussed.",book:{id:"9043",slug:"parenting-studies-by-an-ecocultural-and-transactional-perspective",title:"Parenting",fullTitle:"Parenting - Studies by an Ecocultural and Transactional Perspective"},signatures:"Loredana Benedetto and Massimo Ingrassia",authors:[{id:"193200",title:"Prof.",name:"Loredana",middleName:null,surname:"Benedetto",slug:"loredana-benedetto",fullName:"Loredana Benedetto"},{id:"193901",title:"Prof.",name:"Massimo",middleName:null,surname:"Ingrassia",slug:"massimo-ingrassia",fullName:"Massimo Ingrassia"}]},{id:"72823",title:"Helicopter Parenting and Adolescent Development: From the Perspective of Mental Health",slug:"helicopter-parenting-and-adolescent-development-from-the-perspective-of-mental-health",totalDownloads:984,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Helicopter parenting is a unique form of parenting style that is generally described as highly intensive and highly involved with the children. A particular parenting style influences all phases of development and life style of adolescent. Helicopter parents overly protect their children from the difficulties by setting some set of instructions without consideration of the uniqueness of their children. Recent literature has got huge attention on this parenting style and debating the pros and cons on the development of child. Higher life satisfaction and better psychological wellbeing have been found in the children of highly intrusive parents. When there are positive effects of helicopter parenting, there are negative outcome and impacts that have also been studied. The difficulties in emotional regulation, academic productivity, and social skills among children raised by helicopter parenting have been reported in the literature. Low self-efficacy, lack of trust on peers, and alienation from peers have also been associated with helicopter parenting. The chapter highlights the associated aspects of childhood and adolescence, raised by helicopter parenting. As parents have their own concern about raising their children in certain manner, it is important to understand the underlying mechanism of parenting style. Therefore, this chapter also describes the theoretical framework. The associated mental health issues and supportive psychological intervention to be also discussed.",book:{id:"9043",slug:"parenting-studies-by-an-ecocultural-and-transactional-perspective",title:"Parenting",fullTitle:"Parenting - Studies by an Ecocultural and Transactional Perspective"},signatures:"Deepika Srivastav and M.N. Lal Mathur",authors:[{id:"320545",title:"Ph.D.",name:"Deepika",middleName:null,surname:"Srivastav",slug:"deepika-srivastav",fullName:"Deepika Srivastav"},{id:"322605",title:"Dr.",name:"M.N.Lal",middleName:null,surname:"Mathur",slug:"m.n.lal-mathur",fullName:"M.N.Lal Mathur"}]},{id:"45760",title:"Parenting and Culture – Evidence from Some African Communities",slug:"parenting-and-culture-evidence-from-some-african-communities",totalDownloads:9632,totalCrossrefCites:10,totalDimensionsCites:27,abstract:null,book:{id:"3440",slug:"parenting-in-south-american-and-african-contexts",title:"Parenting in South American and African Contexts",fullTitle:"Parenting in South American and African Contexts"},signatures:"Patricia Mawusi Amos",authors:[{id:"162496",title:"Mrs.",name:"Patricia",middleName:"Mawusi",surname:"Mawusi Amos",slug:"patricia-mawusi-amos",fullName:"Patricia Mawusi Amos"}]},{id:"72914",title:"Parent-Adolescent Relationship and the Impact of Substance Dependency within the Trajectory of Adolescent Substance Use Disorder",slug:"parent-adolescent-relationship-and-the-impact-of-substance-dependency-within-the-trajectory-of-adole",totalDownloads:681,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Adolescents strive for freedom and autonomy; thus, communication with their parents needs to be enhanced. Building solid healthy relationships at this stage of their lives is of utmost importance to help them cope with the changes and challenges they are experiencing. The purpose of this chapter is to explore the parent-adolescent relationship in the substance dependency field. The focus is on the relationship between parents and their adolescents who have a substance use disorder. Parenting adolescents poses its own set of challenges, making it difficult to build and maintain healthy parent-adolescent relationships. We argue that although adolescent substance use disorder has been extensively researched, the relationship between parents and adolescents with substance use disorder has surprisingly not received the same attention. It is this gap that this chapter seeks to address. With this in mind, the ecological systems theory was employed here to shed light on the importance and significance of developing healthy parent-adolescent relationships. The findings show that the parent-adolescent relationship primarily informs the daily living of both the parents and the adolescents. The parent-adolescent relationship is therefore very important as it represents whole-family functioning.",book:{id:"9043",slug:"parenting-studies-by-an-ecocultural-and-transactional-perspective",title:"Parenting",fullTitle:"Parenting - Studies by an Ecocultural and Transactional Perspective"},signatures:"Faith Mathibela and Rebecca Mmamoagi Skhosana",authors:[{id:"317920",title:"Mrs.",name:"Faith",middleName:null,surname:"Mathibela",slug:"faith-mathibela",fullName:"Faith Mathibela"}]},{id:"56390",title:"Introductory Chapter: Sociology of Knowledge and Epistemological Paradox of Globalization",slug:"introductory-chapter-sociology-of-knowledge-and-epistemological-paradox-of-globalization",totalDownloads:1836,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"5924",slug:"epistemology-and-transformation-of-knowledge-in-global-age",title:"Epistemology and Transformation of Knowledge in Global Age",fullTitle:"Epistemology and Transformation of Knowledge in Global Age"},signatures:"Zlatan Delić",authors:[{id:"31746",title:"Dr.",name:"Zlatan",middleName:null,surname:"Delic",slug:"zlatan-delic",fullName:"Zlatan Delic"}]}],onlineFirstChaptersFilter:{topicId:"276",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:140,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:123,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. He won the “Catedra Telefonica” Awards in Modality of Knowledge Transfer, 2017, 2018, and 2019 editions, and awards in Modality of COVID Research in 2020.\n\nPublic References:\nResearcher ID http://www.researcherid.com/rid/N-5967-2014\nORCID https://orcid.org/0000-0002-4621-2768 \nScopus Author ID https://www.scopus.com/authid/detail.uri?authorId=6602376272\nScholar Google https://scholar.google.es/citations?user=G1ks9nIAAAAJ&hl=en \nResearchGate https://www.researchgate.net/profile/Carlos_Travieso",institutionString:null,institution:{name:"University of Las Palmas de Gran Canaria",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"23",title:"Computational Neuroscience",coverUrl:"https://cdn.intechopen.com/series_topics/covers/23.jpg",isOpenForSubmission:!0,editor:{id:"14004",title:"Dr.",name:"Magnus",middleName:null,surname:"Johnsson",slug:"magnus-johnsson",fullName:"Magnus Johnsson",profilePictureURL:"https://mts.intechopen.com/storage/users/14004/images/system/14004.png",biography:"Dr Magnus Johnsson is a cross-disciplinary scientist, lecturer, scientific editor and AI/machine learning consultant from Sweden. \n\nHe is currently at Malmö University in Sweden, but also held positions at Lund University in Sweden and at Moscow Engineering Physics Institute. \nHe holds editorial positions at several international scientific journals and has served as a scientific editor for books and special journal issues. \nHis research interests are wide and include, but are not limited to, autonomous systems, computer modeling, artificial neural networks, artificial intelligence, cognitive neuroscience, cognitive robotics, cognitive architectures, cognitive aids and the philosophy of mind. \n\nDr. Johnsson has experience from working in the industry and he has a keen interest in the application of neural networks and artificial intelligence to fields like industry, finance, and medicine. \n\nWeb page: www.magnusjohnsson.se",institutionString:null,institution:{name:"Malmö University",institutionURL:null,country:{name:"Sweden"}}},editorTwo:null,editorThree:null},{id:"24",title:"Computer Vision",coverUrl:"https://cdn.intechopen.com/series_topics/covers/24.jpg",isOpenForSubmission:!0,editor:{id:"294154",title:"Prof.",name:"George",middleName:null,surname:"Papakostas",slug:"george-papakostas",fullName:"George Papakostas",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002hYaGbQAK/Profile_Picture_1624519712088",biography:"George A. 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He has (co)authored more than 150 publications in indexed journals, international conferences and book chapters, 1 book (in Greek), 3 edited books, and 5 journal special issues. His publications have more than 2100 citations with h-index 27 (GoogleScholar). His research interests include computer/machine vision, machine learning, pattern recognition, computational intelligence. \nDr. Papakostas served as a reviewer in numerous journals, as a program\ncommittee member in international conferences and he is a member of the IAENG, MIR Labs, EUCogIII, INSTICC and the Technical Chamber of Greece (TEE).",institutionString:null,institution:{name:"International Hellenic University",institutionURL:null,country:{name:"Greece"}}},editorTwo:null,editorThree:null},{id:"25",title:"Evolutionary Computation",coverUrl:"https://cdn.intechopen.com/series_topics/covers/25.jpg",isOpenForSubmission:!0,editor:{id:"136112",title:"Dr.",name:"Sebastian",middleName:null,surname:"Ventura Soto",slug:"sebastian-ventura-soto",fullName:"Sebastian Ventura Soto",profilePictureURL:"https://mts.intechopen.com/storage/users/136112/images/system/136112.png",biography:"Sebastian Ventura is a Spanish researcher, a full professor with the Department of Computer Science and Numerical Analysis, University of Córdoba. Dr Ventura also holds the positions of Affiliated Professor at Virginia Commonwealth University (Richmond, USA) and Distinguished Adjunct Professor at King Abdulaziz University (Jeddah, Saudi Arabia). Additionally, he is deputy director of the Andalusian Research Institute in Data Science and Computational Intelligence (DaSCI) and heads the Knowledge Discovery and Intelligent Systems Research Laboratory. He has published more than ten books and over 300 articles in journals and scientific conferences. Currently, his work has received over 18,000 citations according to Google Scholar, including more than 2200 citations in 2020. In the last five years, he has published more than 60 papers in international journals indexed in the JCR (around 70% of them belonging to first quartile journals) and he has edited some Springer books “Supervised Descriptive Pattern Mining” (2018), “Multiple Instance Learning - Foundations and Algorithms” (2016), and “Pattern Mining with Evolutionary Algorithms” (2016). He has also been involved in more than 20 research projects supported by the Spanish and Andalusian governments and the European Union. He currently belongs to the editorial board of PeerJ Computer Science, Information Fusion and Engineering Applications of Artificial Intelligence journals, being also associate editor of Applied Computational Intelligence and Soft Computing and IEEE Transactions on Cybernetics. Finally, he is editor-in-chief of Progress in Artificial Intelligence. He is a Senior Member of the IEEE Computer, the IEEE Computational Intelligence, and the IEEE Systems, Man, and Cybernetics Societies, and the Association of Computing Machinery (ACM). Finally, his main research interests include data science, computational intelligence, and their applications.",institutionString:null,institution:{name:"University of Córdoba",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"26",title:"Machine Learning and Data Mining",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",isOpenForSubmission:!0,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. 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Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7064",title:"Current Perspectives in Human Papillomavirus",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7064.jpg",slug:"current-perspectives-in-human-papillomavirus",publishedDate:"May 2nd 2019",editedByType:"Edited by",bookSignature:"Shailendra K. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:303,paginationItems:[{id:"280338",title:"Dr.",name:"Yutaka",middleName:null,surname:"Tsutsumi",slug:"yutaka-tsutsumi",fullName:"Yutaka Tsutsumi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/280338/images/7961_n.jpg",biography:null,institutionString:null,institution:{name:"Fujita Health University",country:{name:"Japan"}}},{id:"116250",title:"Dr.",name:"Nima",middleName:null,surname:"Rezaei",slug:"nima-rezaei",fullName:"Nima Rezaei",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/116250/images/system/116250.jpg",biography:"Professor Nima Rezaei obtained an MD from Tehran University of Medical Sciences, Iran. He also obtained an MSc in Molecular and Genetic Medicine, and a Ph.D. in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also completed a short-term fellowship in Pediatric Clinical Immunology and Bone Marrow Transplantation at Newcastle General Hospital, England. Dr. Rezaei is a Full Professor of Immunology and Vice Dean of International Affairs and Research, at the School of Medicine, Tehran University of Medical Sciences, and the co-founder and head of the Research Center for Immunodeficiencies. He is also the founding president of the Universal Scientific Education and Research Network (USERN). Dr. Rezaei has directed more than 100 research projects and has designed and participated in several international collaborative projects. He is an editor, editorial assistant, or editorial board member of more than forty international journals. He has edited more than 50 international books, presented more than 500 lectures/posters in congresses/meetings, and published more than 1,100 scientific papers in international journals.",institutionString:"Tehran University of Medical Sciences",institution:{name:"Tehran University of Medical Sciences",country:{name:"Iran"}}},{id:"180733",title:"Dr.",name:"Jean",middleName:null,surname:"Engohang-Ndong",slug:"jean-engohang-ndong",fullName:"Jean Engohang-Ndong",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180733/images/system/180733.png",biography:"Dr. Jean Engohang-Ndong was born and raised in Gabon. After obtaining his Associate Degree of Science at the University of Science and Technology of Masuku, Gabon, he continued his education in France where he obtained his BS, MS, and Ph.D. in Medical Microbiology. He worked as a post-doctoral fellow at the Public Health Research Institute (PHRI), Newark, NJ for four years before accepting a three-year faculty position at Brigham Young University-Hawaii. Dr. Engohang-Ndong is a tenured faculty member with the academic rank of Full Professor at Kent State University, Ohio, where he teaches a wide range of biological science courses and pursues his research in medical and environmental microbiology. Recently, he expanded his research interest to epidemiology and biostatistics of chronic diseases in Gabon.",institutionString:"Kent State University",institution:{name:"Kent State University",country:{name:"United States of America"}}},{id:"188773",title:"Prof.",name:"Emmanuel",middleName:null,surname:"Drouet",slug:"emmanuel-drouet",fullName:"Emmanuel Drouet",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/188773/images/system/188773.png",biography:"Emmanuel Drouet, PharmD, is a Professor of Virology at the Faculty of Pharmacy, the University Grenoble-Alpes, France. As a head scientist at the Institute of Structural Biology in Grenoble, Dr. Drouet’s research investigates persisting viruses in humans (RNA and DNA viruses) and the balance with our host immune system. He focuses on these viruses’ effects on humans (both their impact on pathology and their symbiotic relationships in humans). He has an excellent track record in the herpesvirus field, and his group is engaged in clinical research in the field of Epstein-Barr virus diseases. He is the editor of the online Encyclopedia of Environment and he coordinates the Universal Health Coverage education program for the BioHealth Computing Schools of the European Institute of Science.",institutionString:null,institution:{name:"Grenoble Alpes University",country:{name:"France"}}},{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",biography:"Dr. Rodriguez-Morales is an expert in tropical and emerging diseases, particularly zoonotic and vector-borne diseases (especially arboviral diseases). He is the president of the Travel Medicine Committee of the Pan-American Infectious Diseases Association (API), as well as the president of the Colombian Association of Infectious Diseases (ACIN). He is a member of the Committee on Tropical Medicine, Zoonoses, and Travel Medicine of ACIN. He is a vice-president of the Latin American Society for Travel Medicine (SLAMVI) and a Member of the Council of the International Society for Infectious Diseases (ISID). Since 2014, he has been recognized as a Senior Researcher, at the Ministry of Science of Colombia. He is a professor at the Faculty of Medicine of the Fundacion Universitaria Autonoma de las Americas, in Pereira, Risaralda, Colombia. He is an External Professor, Master in Research on Tropical Medicine and International Health, Universitat de Barcelona, Spain. He is also a professor at the Master in Clinical Epidemiology and Biostatistics, Universidad Científica del Sur, Lima, Peru. In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. 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Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343",scope:"Biomedical Engineering is one of the fastest-growing interdisciplinary branches of science and industry. 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This series is intended for doctors, engineers, and scientists involved in biomedical engineering or those wanting to start working in this field.",coverUrl:"https://cdn.intechopen.com/series/covers/7.jpg",latestPublicationDate:"August 3rd, 2022",hasOnlineFirst:!0,numberOfOpenTopics:3,numberOfPublishedChapters:107,numberOfPublishedBooks:12,editor:{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}},subseries:[{id:"7",title:"Bioinformatics and Medical Informatics",keywords:"Biomedical Data, Drug Discovery, Clinical Diagnostics, Decoding Human Genome, AI in Personalized Medicine, Disease-prevention Strategies, Big Data Analysis in Medicine",scope:"Bioinformatics aims to help understand the functioning of the mechanisms of living organisms through the construction and use of quantitative tools. The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",annualVolume:11403,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",institutionString:null,institution:{name:"Medical University of Silesia",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"5886",title:"Dr.",name:"Alexandros",middleName:"T.",surname:"Tzallas",fullName:"Alexandros Tzallas",profilePictureURL:"https://mts.intechopen.com/storage/users/5886/images/system/5886.png",institutionString:"University of Ioannina, Greece & Imperial College London",institution:{name:"University of Ioannina",institutionURL:null,country:{name:"Greece"}}},{id:"257388",title:"Distinguished Prof.",name:"Lulu",middleName:null,surname:"Wang",fullName:"Lulu Wang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRX6kQAG/Profile_Picture_1630329584194",institutionString:"Shenzhen Technology University",institution:{name:"Shenzhen Technology University",institutionURL:null,country:{name:"China"}}},{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",fullName:"Reda R. Gharieb",profilePictureURL:"https://mts.intechopen.com/storage/users/225387/images/system/225387.jpg",institutionString:"Assiut University",institution:{name:"Assiut University",institutionURL:null,country:{name:"Egypt"}}}]},{id:"8",title:"Bioinspired Technology and Biomechanics",keywords:"Bioinspired Systems, Biomechanics, Assistive Technology, Rehabilitation",scope:'Bioinspired technologies take advantage of understanding the actual biological system to provide solutions to problems in several areas. Recently, bioinspired systems have been successfully employing biomechanics to develop and improve assistive technology and rehabilitation devices. The research topic "Bioinspired Technology and Biomechanics" welcomes studies reporting recent advances in bioinspired technologies that contribute to individuals\' health, inclusion, and rehabilitation. Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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