\r\n\tAs the subject of adhesives is in constant development, this book's purpose is to get together information about adhesives science and technology, recent advances, and applications that use adhesive technology. Also, to make these contents available to engineering students, engineers, researchers, and the people interested in this topic. The book is expected to present works that aim to contribute to the development of new technologies and the use of non-traditional materials in engineering.
",isbn:"978-1-83880-670-5",printIsbn:"978-1-83880-669-9",pdfIsbn:"978-1-83880-671-2",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"c58b7d4c17e2a202af1dc4b906b7becb",bookSignature:"Prof. António Bastos Pereira and Dr. Alexandre Luiz Pereira",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11819.jpg",keywords:"The Technology of the Adhesives, Recent Advances, New Perspectives, Structural Adhesives Bonding, Durability of Structural Adhesives, New Applications, Repair of Composites, Bonding of Composites, Experimental Mechanics Tests, Thermal Analysis, Finite Element Method, Numerical Analysis.",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 15th 2022",dateEndSecondStepPublish:"June 22nd 2022",dateEndThirdStepPublish:"August 21st 2022",dateEndFourthStepPublish:"November 9th 2022",dateEndFifthStepPublish:"January 8th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Dr. António Pereira is a professor and researcher, who graduated from the University of Porto, and gained experience as an engineer working at Renault, with an h-index of 23, and more than 1500 citations for 70 papers published in SCI journals.",coeditorOneBiosketch:"An active researcher in Solid Mechanics, Dr. Alexandre Luiz Pereira holds a degree in Mathematics from the State University of Rio de Janeiro, and a degree in Mechanical Engineering from the Fluminense Federal University in Brazil.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"211131",title:"Prof.",name:"António",middleName:"Bastos",surname:"Pereira",slug:"antonio-pereira",fullName:"António Pereira",profilePictureURL:"https://mts.intechopen.com/storage/users/211131/images/system/211131.png",biography:"Founding shareholder and Director of Martifer Group (ca. 3500 employees) (1990-1999) - was responsible for the planning and production of about 500 steel structures and industrial equipment with a total amount exceeding 100 million euros.\nAssistant Professor at the Department of Mechanical Engineering, University of Aveiro, since 2000. Board Member and Member of the Executive Committee at the Department of Mechanical Engineering, University of Aveiro (2011 – 2015), currently Director of TEMA - Centre for Mechanical Technology and Automation.\nHis main research area has been mechanics of composite materials, with particular emphasis on delamination fracture mechanics. He has published 44 papers in SCI journals and has delivered 30 presentations at international conferences. His h-index at scopus is 16 with more than 770 citations.",institutionString:"University of Aveiro",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}}],coeditorOne:{id:"452095",title:"Dr.",name:"Alexandre Luiz",middleName:null,surname:"Pereira",slug:"alexandre-luiz-pereira",fullName:"Alexandre Luiz Pereira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003LeECuQAN/Profile_Picture_1642158596909",biography:"Alexandre Luiz Pereira is Ph.D. in Mechanical Engineering and Materials Technology. During the period of the Ph.D., he did a Postgraduate Internship at the Department of Mechanical Engineering at the University of Aveiro/Portugal (UA). Since 2014 he has been a professor and researcher at the Federal Center of Technological Education in Rio de Janeiro (CEFET/RJ). He is currently the coordinator of the Mechanical Engineering course at the CEFET/RJ Campus Angra dos Reis. His main research areas focus on the study of materials technology, from structural and hybrid composites, hyperelastic materials, and adhesives joints.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"0",totalChapterViews:"0",totalEditedBooks:"0",institution:null},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"14",title:"Materials Science",slug:"materials-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"444312",firstName:"Sara",lastName:"Tikel",middleName:null,title:"Ms.",imageUrl:"https://mts.intechopen.com/storage/users/444312/images/20015_n.jpg",email:"sara.t@intechopen.com",biography:"As an Author Service Manager, my responsibilities include monitoring and facilitating all publishing activities for authors and editors. 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Churchill, Maja Dutour Sikirić, Božana Čolović and Helga Füredi Milhofer",coverURL:"https://cdn.intechopen.com/books/images_new/8812.jpg",editedByType:"Edited by",editors:[{id:"219335",title:"Dr.",name:"David",surname:"Churchill",slug:"david-churchill",fullName:"David Churchill"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"39220",title:"Numerical Simulations of Water Waves' Modulational Instability Under the Action of Wind and Dissipation",doi:"10.5772/48595",slug:"numerical-simulations-of-water-waves-modulational-instability-under-the-action-of-wind-and-dissipati",body:'The seek of uniform, propagative wave train solutions of the fully nonlinear potential equations has been a major topic for centuries. [5] was the first to propose an expression of such waves, the so called Stokes’ waves. However, pioneer works of [6] emphasized that such waves might be unstable, providing a geometric condition for this stability problem. Later on, [1] showed analytically that Stokes’ waves of moderate amplitude are unstable to long wave perturbations of small amplitude travelling in the same direction. This instability is named the Benjamin-Feir instability (or modulational instability). This result was derived independently by [7] in an averaged Lagrangian approach, and by [8] who used an Hamiltonian formulation of the water wave problem. Using this approach, the latter author derived the nonlinear Schrödinger equation (NLS), and confirmed the previous stability results.
Within the last fifty years, the study of this instability became central for fundamental and applied research. The modulation instability is one of the most important mechanisms for the formation of rogue waves [9]. A complete review on the various phenomena yielding to rogue waves can be found in the book of [10]. In the absence of forcing and damping, Stokes’ waves of specific initial steepness are submitted to this instability, when they encounter perturbations of specific wave numbers [11, 12]. In this case, they encounter a nonlinear quasi-recursive evolution, the so called Fermi-Pasta-Ulam recurrence phenomenon ([13]). This phenomenon corresponds to a series of modulation - demodulation cycles, during which initially uniform wave trains become modulated, leading possibly to the formation of a huge wave. Modulation is due to an energy transfer from the wave carrier to the unstable sidebands. In the wave number space, these unstable sidebands are located in a finite narrow band centered around the carrier wave number. During the demodulation, the energy returns to the fundamental component of the original wave train. Using the Zakharov equation, [14] questions the relevance of the Benjamin-Feir index to indicate the intensity of modulational instability. Indeed, this index is often used to quantify the intensity of interactions between a carrier wave and the finite amplitude sidebands. However, [14] emphasized that nonlinear interactions occur also for sidebands located beyond the Benjamin-Feir instability domain.
A damped nonlinear Schrödinger equation (dNLS) was derived by [15] who revisited the Benjamin-Feir instability in the presence of dissipation. They studied numerically the evolution of narrow bandwidth waves of moderate amplitude. More recently [2] investigated theoretically the modulational instability within the framework of the dNLS equation and demonstrated that any amount of dissipation stabilizes the modulational instability in the sense of Lyapunov. Namely, they showed that the zone of unstable region, in the wavenumber space, shrinks as time increases. As a result, any initially unstable mode of perturbation will finally become stable. [2] have confirmed their theoretical predictions by laboratory experiments for waves of small to moderate amplitude. Later, [3] developed fully nonlinear numerical simulations which agreed with the theory and experiments of [2].
From the latter study we could conclude that dissipation may prevent the development of the Benjamin-Feir instability. This effect questions the occurrence of modulational instability of water wave trains in the field. [16] speculated about the effect of dissipation on the early development of rogue waves and raised the question whether or not the Benjamin-Feir instability was able to spawn a rogue wave.
Nevertheless, these authors did not take the effect of wind into account. When considering the occurrence of modulational instability in the field, the role of wind upon this instability in the presence of dissipation needs to be addressed. Based on this assumption, [4] derived a forced and damped nonlinear Schrödinger equation (fdNLS), and extended the analysis of [2] when wind input is introduced. The influence of wind was introduced through a pressure term acting at the interface, in phase with the wave slope, accordingly to Miles’ theory [17]. This quasi-laminar theory of wind wave amplification is based on the Miles’ shear flow instability. This mechanism of wave amplification is a resonant interaction between water waves and a plane shear flow in air which occurs at the critical height where the wind velocity matches the phase velocity of the surface waves. Stokes waves propagating in the presence of such a forcing, when not submitted to modulational instability, encounter an exponential growth. They demonstrated, within the framework of fdNLS equation, that Stokes’ waves were unstable to modulational instability as soon as the friction velocity is larger than a threshold value. Conversely, for a given friction velocity it was found that only carrier waves presenting frequencies (or wavenumbers) lower than a threshold value are subject to Benjamin-Feir instability. Otherwise, due to dissipation, modulational instability restabilizes in the sense of Lyapunov.
As it was mentioned, this physical result is based on the solution of an approached model, the fdNLS equation. Thus, a proper verification is required. However, the phenomenon at hand is based on the long-time behavior of the modulated wave train when propagating in the presence of wind and dissipation. This remark explains the difficulty to provide an experimental verification of the theory. This physical problem is then especially well adapted for a numerical verification. This verification was performed in a first time by [18], who investigated the development of the modulational instability under wind action and viscous dissipation within the framework of fully nonlinear potential equations. This work is an extension of that of [3] when wind input is considered. Later on, [19] emphasized that the equations empirically introduced by [3] were not completely representative of the dispersion relation in the presence of damping, and corrected the equations to overcome this problem, in accordance with the demonstration of [20] and [21].
This work aims to emphasize how numerical simulations can provide useful information to validate long term results based on weakly nonlinear theory. Furthermore, the numerical approach presented here constitutes an extension of the results of [4] to higher orders of nonlinearity and larger band spectra, too. The long time evolution of modulated wave trains can be investigated in a way not allowed by fdNLS equation. The numerical simulations enable to produce results concerning the long time behavior of the modulated wave train. Especially, the phenomenon of permanent frequency downshift will be investigated.
In section 2, the governing equations of the problem are presented. Section 3 presents the weakly nonlinear model obtained by [4], and summarizes their results. The numerical model used to investigate the long time behavior of the modulated wave train is developed in section 4. The initial conditions used to support the numerical strategy for validating the theory introduced by [4] is presented in section 5. Finally, the results obtained are described in section 6.
The approach used in this study is based on the potential flow theory. The fluid is assumed to be incompressible, inviscid, and animated by an irrotational motion. Thus, the fluid velocity derives from a potential
The wind has already been introduced in the dynamic boundary condition through a pressure term acting at the free surface in several numerical potential models. Among them, one may cite [22], [23] and [24] who introduced and discussed this approach for BIEM methods and [25], [26], and [27] who extended it to HOS methods. The pressure term used here is based on the Miles’ theory [17], accordingly to the approach of [4]. The viscosity was introduced heuristically by [3] who used the HOS method to address the question raised in [2] on the restabilisation of the Benjamin-Feir instability of a Stokes wave train in the presence of dissipation. The introduction was made through the addition of a damping term in the dynamic boundary condition. However, a proper derivation of the kinematic and dynamic boundary condition in the presence of viscosity was made by [20], and later on by [21]. A modification of both kinematic and dynamic condition was found, resulting in a slight difference in the dispersion relation, as it was discussed by [19]. Finally, the system of equations corresponding to the potential theory, in the presence of wind and viscous damping reads
where
where
The Nonlinear Schrödinger equation can be obtained from the fully nonlinear potential theory by using the multi-scale method. The equations are expanded in Taylor series, around a small parameter,
to investigate both damping and amplification effects on the Benjamin-Feir instability. Herein,
[4] found that the stability of the envelope depends on the sign of the constant
This condition can be rewritten as follows
where
Within the framework of two-dimensional flows, a High-Order Spectral Method is used to solve numerically the basic partial differential equations corresponding to equations (1 - 4). The lateral conditions correspond here to space-periodic conditions. The horizontal bottom condition corresponds to infinite depth. The velocity potential is expanded in a series of eigenfunctions fulfilling both these lateral and bottom conditions. A spectral treatment is well adapted to investigate numerically the long time behavior of periodic water waves encountering the modulational instability.
We first introduce the following dimensionless variables into equations (1), (2), (3) and (4):
where
Following [8], we introduce the velocity potential at the free surface
with
The main difficulty in this approach is the computation of the vertical velocity at the free surface,
The term
At a given instant of time,
The boundary conditions, together with the Laplace equations
Note that
Substitution of equation (20) into the set of equations (18 - 19) provides an expression of the modes
This expression might be substituted into the kinematic and dynamic boundary conditions (13) and (14), yielding to the evolution equations for
where
In fact, the version of [29] differs from the version of [28] not only in the expression of the approximated vertical velocity at the surface, but also in its subsequent treatment in the free surface equations. According to [29], the surface equations must be truncated at consistent nonlinear order if they are to simulate a conservative Hamiltonian system. This requires to treat carefully all nonlinear terms containing
From a numerical point of view, one part of the initial condition is obtained by considering a Stokes wavetrain
One of the difficulties involved in this study is to define clearly the stability. Indeed, since Stokes’ waves are propagating under the action of wind and viscosity, this flow cannot be considered stationary nor periodic. Discussing of the combined influence of wind forcing and damping on the modulational instability, however, implies to define a reference flow. In order to do so, we first consider the evolution of the unperturbed Stokes’ waves in the presence of forcing and dissipation (unseeded case). It is checked that the instability does not develop spontaneously in the laps of time considered. Afterwards, we consider the evolution of the initially perturbed Stokes’ wave train under the same conditions of wind forcing and damping (seeded case). The nonlinear evolution of the Stokes’ wavetrain perturbed by the modulational instability in the presence of wind and dissipation is then compared to that of the reference flow. In that way, the deviation from the reference flow can be interpreted in terms of modulational instability, and the influence of wind forcing and dissipation can be analyzed. Following our previous works [18, 19], the evolution of the energy of the perturbation is thus obtained.
Figures 1 and 2 present the time evolution of the amplitudes of three components of the water waves’ spectrum. The mode
Time evolution of the normalized amplitudes of the fundamental mode (
Time evolution of the normalized amplitudes of the fundamental mode (
Figure 1 shows the time evolution of the normalized amplitudes
Surface wave profiles at different times, obtained while propagating initial condition corresponding to seeded case with
Surface wave profiles at different times, obtained while propagating initial condition corresponding to seeded case with
Figure 2 corresponds to
In our previous work [18], we assumed that the dominant mode describes the main behavior of a wave train, and we introduced a norm measuring the distance between the fundamental modes of the unperturbed and perturbed Stokes wave corresponding to unseeded case and seeded case respectively. However, it is more consistent to consider the energy of the perturbation, as it was stated in [19]. Thus, another norm can be introduced as
where
Time evolution of the norm
Theoretical ( —) and numerical ( –
Figure 4 shows the time evolution of this norm for two sets of parameters
Many numerical simulations have been run for various values of the parameters
This result provides a validation of the weakly nonlinear theory obtained in the framework of nonlinear Schrödinger equation. However, the numerical approach allows to investigate the long time evolution of the wave train, taking into account the strongly nonlinear behavior of water waves. One phenomenon especially illustrates this nonlinear behavior: the permanent frequency downshift. This phenomenon was discussed by [32] and [33] within the framework of gravity waves. These authors considered that dissipation due to breaking wave was responsible for this permanent downshift. [34] modeled the phenomenon in the presence of wind and eddy viscosity, and latter on [35] in the presence of only molecular viscosity. All these works are based on equations valid up to fourth order in nonlinearity, or higher. Indeed, it is well known that the frequency downshift cannot be observed in the framework of nonlinear Schrödinger equation, which preserves the symmetry between subharmonic and superharmonic components. In fact, [36] concluded that in the absence of wind and dissipation, it was not possible to observe the phenomenon even with higher order equations.
If going back to figure 1, for the initially perturbed case (seeded case), the development of the modulational instability is responsible for the frequency downshift observed at around
Nondimensional time
To investigate the effect of wind and damping, another series of simulations is performed. Namely, the values of
In this work, it was evidence how numerical simulations can provide a good demonstration of a weakly nonlinear theory that cannot be achieved by means of experimental demonstration. In this study, an extension of the work of [4] to the fully nonlinear case was suggested. Within the framework of the NLS equation the latter authors considered the modulational instability of Stokes wave trains suffering both effects of wind and dissipation. The results they obtained show that the modulational instability depends on both frequency of the carrier wave and strength of the wind velocity. They plotted the curve corresponding to marginal stability in the
The determination within the chapter is based on a paper [1]. Bayes classifiers are broadly utilized right now for recognition, identification, and knowledge discovery. The fields of application are, for case, image processing, personalized medicine [2], chemistry (QSAR (quantitative structure-activity relationship) [3, 4]; see Figure 1). The especial importance Bayes Classifiers have in Medical Diagnostics and Bioinformatics. Cogent illustrations of this can be found in the work of Raymer and colleagues [5].
\nQuantitative structure-activity relationship.
Let us give some example of using QSAR from papers [3, 4]:
\n“Molecular recognition and binding performed by proteins are the background of all biochemical processes in a living cell. In particular, the usual mechanism of drug function is effective binding and inhibition of activity of a target protein. Direct modeling of molecular interactions in protein-inhibitor complexes is the basis of modern computational drug design but is an extremely complicated problem. In the current paradigm, site similarity is recognized by the existence of chemically and spatially analogous regions from binding sites. We present a novel notion of binding site local similarity based on the analysis of complete protein environments of ligand fragments. Comparison of a query protein binding site (target) against the 3D structure of another protein (analog) in complex with a ligand enables ligand fragments from the analog complex to be transferred to positions in the target site, so that the complete protein environments of the fragment and its image are similar. The revealed environments are similarity regions and the fragments transferred to the target site are considered as binding patterns. The set of such binding patterns derived from a database of analog complexes forms a cloudlike structure (fragment cloud), which is a powerful tool for computational drug design.”
\nHowever, these Bayes classifiers have momentous property—by strange way the Naive Bayes classifier more often than not gives a decent and great description of recognition. More complex models of Bayes classifier cannot progress it significantly [1]. In the paper [6] creators clarify this exceptional property. In any case, they utilize a few suspicions (zero–one misfortune) which diminish all-inclusiveness and simplification of this proof. We allow in this chapter a common verification of Naive Bayes classifier optimality. The induction within the current chapter is comparative to [1]. The consequent attractive consideration of Naive Bayes classifier optimality problem was made in [7, 8]. Be that as it may, shockingly these papers do not incorporate any investigation of the past one [1].
\nWe would like to prove Naive Bayes classifier optimality using QSAR terminology. Indeed, we use QSAR only for clearness; the proof is correct for any field of use of Naive Bayes classifier.
\nLet us define the essential issue that we attempt to unravel within the chapter. Assume that we have a set of states for a complex of ligand-active site of protein and a set of factors that characterize these states. For each state, we know the likelihood dispersion for each factor. In any case, we have no data of the approximate relationships of the factors. Presently, assume that we know factor values for some test of the state. What is the probability that this test corresponds to some state? It could be a commonplace issue of recognition over a condition of incomplete data.
\nIn the simplest case, we can define two states for “ligand-active site of protein” complex. It is 0 (ligand is not bound to active site of protein) or 1 (ligand is not bound to active site of protein).
\nThe next step is definition of factors (reliabilities below) that characterize strength of a bond for “ligand-active site of protein” complex. Let us grant an illustration of factors (reliabilities below) from experience of QSAR in papers [3, 4]:
\n“First, consider the protein 5 A°-environment A = {a1, a2,…aN} of one ligand atom X in the analog protein, that is, all atoms from the binding site that are in the 5 A°-neighborhood of X. Suppose that the complete target binding site T consists of N′ atoms: T = {t1, t2,…tN’} and there exists a subset T0\n
Function
R = 2n/(N + N′), using the notation presented above. In fact, we use a somewhat more complicated definition that accounts for the quality of spatial superposition of matched atoms and their distance from X′.”
\nWe do not want to discuss here these definitions for these factors and states. Our purpose is not the demonstration of effectiveness of these definitions or effectiveness of QSAR. The interested reader can learn it from papers [3, 4] and references inside of these papers. As we said above, we use QSAR only for clearness; the proof is correct for any field of use of Naive Bayes classifier.
\nLet us consider the case when no relationships exist between reliabilities. In this case, the Naive Bayes model is a correct arrangement of the issue. We demonstrate in this chapter that for the case that we don’t know relationships between reliabilities even approximately—the Naive Bayes model is not correct, but ideal arrangement in a few senses. More point by point, we demonstrate that the Naive Bayes model gives minimal mean error over all conceivable models of relationship. We assume in this confirmation that all relationship models have the same likelihood. We think that this result can clarify the depicted over secretive optimality of Naive Bayes model.
\nThe Chapter is built as described in the following statements. We grant correct numerical description of the issue for two states and two reliabilities in Section 2. We characterize our notations in Section 3. We define general form of conditional likelihood for all conceivable relationships of our reliabilities in Section 4. We characterize the limitations of the functions depicting the relationships in Section 5. We find the formula for an interval between two models of probability (correlation) in Section 6. We discover constraints for our fundamental functions in Section 7. We illuminate our primary issue; we demonstrate Naive Bayes model’s optimality for uniform distribution of all conceivable relationships in Section 8. We discover mean error between the Naive Bayes model and a genuine model for uniform distribution of all conceivable relationships in Section 9. We consider the case of more than two states and reliabilities in Section 10. We make conclusions in Section 11.
\nSuppose that A is a state for “ligand-active site of protein” complex. It is 0 (ligand is not bound to active site of protein) or 1 (ligand is not bound to active site of protein). Accept that the \n
We want to find the likelihood
\nin terms of \n
\n\n
\n\n
here
\n\n\n
We can find
\nLet us define the function \n
Let us say that if \n
then
\nLet us define the following
Take attention that since \n
To be brief, let us use the following concise designation:
\nBy the definition
\nWe currently obtain
\nAs a result from Eqs. (2) and (3)
\nNow from Eq. (1)
\nNote, that for values of \n
We can write
\nAs a result
\nThus, we obtain the following condition:
\nand similarly
\nSimilarly, we can get
\nObviously
\nAll the solutions of Eqs. (11)–(15) together with (8) can define the set of all possible realizations of \n
Let us give some example of a solution of (11), (12) and (14), (15):
\nLet \n
We define the distance between the proposed approximation of \n
Now we have from Eqs. (2) and (3) and Eqs. (4)–(7)
\nHere
\nWe will consider further all functions with arguments \n
By the same way
\nWe know that functions \n
By the same way
\nWe shall find the best approximation of \n
where the expected value (or expectation or mathematical expectation or mean or the first moment) \n
For the sake of brevity, we denote
\nThus
\nIt remains to calculate the expected value in Eq. (19).
\nWe have by obvious assumptions
\nLemma 1
\nProof: We can take into the consideration the function \n
Here \n
All matrixes \n
This density function should be symmetric according to transpositions of columns and rows of the matrix \n
We can consider function \n
We can transpose columns and rows \n
From this equation we can conclude that \n
and
\nFrom
\nwe can conclude that
\nSo we can obtain that \n
Lemma 2: Probability distribution functions \n
Proof: Let us make sampling of the function \n
All columns \n
From this equation, we can conclude that function \n
From (20) we obtain
\nLet us define
\nBy Lemma 1, \n
It remains to find
\nSince
\nif the expression in square brackets is minimized at each point, then the whole integral in Eq. (22) is minimized. Thus, we may proceed as follows:
\nHence the optimum \n
The mean distance from (18) is
\nwhere \n
From this equation we can find boundaries of the \n
The second condition is
\nSo from these two equations, we can conclude
\nIn the next step, we would like find function \n
Restrictions for function \n
In discrete form (for \n
Let us define a function \n
Then the function that satisfies equal probability distribution with considering restrictions (i) and (ii) is the following:
\nhere \n
We can define the constant \n
It can be proved for \n
Here we can find \n
Quest function \n
where
\nFrom Eqs. (24) and (25), we can find
\nwhere \n
If \n
where \n
Let A be a state, with values in set \n
We want to find the probability \n
We have evidential restraints for\n
Using as an illustration the QSAR, we demonstrated effectively that the Naive Bayes model gives minimal mean error over uniform dispersion of all conceivable relationships between characteristic reliabilities. This result can clarify the portrayed over secretive optimality of Naive Bayes model. We too found the mean error that the Naive Bayes model gives for uniform distribution of all conceivable relationships of reliabilities.
\nMedicinal chemistry (quantitative structure-activity relationships, QSAR) prediction increasingly relies on Bayesian network-based methods. Its importance derives partly from the difficulty and inaccuracies of present quantum chemical models (e.g., in SYBYL and other software) and from the impracticality of sufficient characterization of structure of drug molecules and receptor active sites, including vicinal waters in and around hydrophobic pockets in active sites. This is particularly so for biologicals (protein and nucleic acid APIs (nucleic acid active pharmaceutical ingredients)) and target applications that exhibit extensive inter-receptor trafficking, genomic polymorphisms, and other system biology phenomena. The effectiveness and accuracy of Bayesian methods for drug development likewise depend on certain prerequisites, such as an adequate distance metric by which to measure similarity/difference between combinatorial library molecules and known successful ligand molecules targeting a particular receptor and addressing a particular clinical indication. In this connection, the distance metric proposed in Section 6 of the chapter manuscript and the associated Lemmas and Proofs are of substantial value in the future of high-throughput screening (HTS) and medicinal chemistry.
\nHowever, our purpose here was not demonstration of effectiveness of these definitions or effectiveness of QSAR. The interested reader can learn it from papers [3, 4] and references inside of these papers. As we said above, we use QSAR only for clearness; the proof is correct for any field of use of Naive Bayes classifier.
\nSupporting women in scientific research and encouraging more women to pursue careers in STEM fields has been an issue on the global agenda for many years. But there is still much to be done. And IntechOpen wants to help.
",metaTitle:"IntechOpen Women in Science Program",metaDescription:"Supporting women in scientific research and encouraging more women to pursue careers in STEM fields has been an issue on the global agenda for many years. But there is still much to be done. And IntechOpen wants to help.",metaKeywords:null,canonicalURL:null,contentRaw:'[{"type":"htmlEditorComponent","content":"At IntechOpen, we’re laying the foundations for the future by publishing the best research by women in STEM – Open Access and available to all. Our Women in Science program already includes six books in progress by award-winning women scientists on topics ranging from physics to robotics, medicine to environmental science. Our editors come from all over the globe and include L’Oreal–UNESCO For Women in Science award-winners and National Science Foundation and European Commission grant recipients.
\\n\\nWe aim to publish 100 books in our Women in Science program over the next three years. We are looking for books written, edited, or co-edited by women. Contributing chapters by men are welcome. As always, the quality of the research we publish is paramount.
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\\n\\n“My scientific path has given me the opportunity to work with colleagues all over Europe, including Germany, France, and Norway. Editing the book Graph Theory: Advanced Algorithms and Applications with IntechOpen emphasized for me the importance of providing valuable, Open Access literature to our scientific colleagues around the world. So I am highly enthusiastic about the Women in Science book collection, which will highlight the outstanding accomplishments of women scientists and encourage others to walk the challenging path to becoming a recognized scientist." Beril Sirmacek, TU Delft, The Netherlands
\\n\\nAdvantages of Publishing with IntechOpen
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\n\nWe aim to publish 100 books in our Women in Science program over the next three years. We are looking for books written, edited, or co-edited by women. Contributing chapters by men are welcome. As always, the quality of the research we publish is paramount.
\n\nAll project proposals go through a two-stage peer review process and are selected based on the following criteria:
\n\nPlus, we want this project to have an impact beyond scientific circles. We will publicize the research in the Women in Science program for a wider general audience through:
\n\nInterested? If you have an idea for an edited volume or a monograph, we’d love to hear from you! Contact Ana Pantar at book.idea@intechopen.com.
\n\n“My scientific path has given me the opportunity to work with colleagues all over Europe, including Germany, France, and Norway. Editing the book Graph Theory: Advanced Algorithms and Applications with IntechOpen emphasized for me the importance of providing valuable, Open Access literature to our scientific colleagues around the world. So I am highly enthusiastic about the Women in Science book collection, which will highlight the outstanding accomplishments of women scientists and encourage others to walk the challenging path to becoming a recognized scientist." Beril Sirmacek, TU Delft, The Netherlands
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González Rodríguez, Rocío Baños Rodríguez and Citlalli Hernández Guerrero",authors:[{id:"108938",title:"Dr.",name:"Victor",middleName:null,surname:"Bravo-Cuevas",slug:"victor-bravo-cuevas",fullName:"Victor Bravo-Cuevas"},{id:"109673",title:"Dr.",name:"Katia",middleName:null,surname:"González-Rodríguez",slug:"katia-gonzalez-rodriguez",fullName:"Katia González-Rodríguez"},{id:"109689",title:"Prof.",name:"Rocio",middleName:"Elizabeth",surname:"Baños-Rodríguez",slug:"rocio-banos-rodriguez",fullName:"Rocio Baños-Rodríguez"},{id:"109690",title:"BSc.",name:"Citlalli",middleName:null,surname:"Hernández-Guerrero",slug:"citlalli-hernandez-guerrero",fullName:"Citlalli Hernández-Guerrero"}]},{id:"36318",doi:"10.5772/35865",title:"Ground Penetrating Radar: A Useful Tool for Shallow Subsurface Stratigraphy Characterization",slug:"ground-penetrating-radar-a-useful-tool-for-shallow-subsurface-stratigraphy-characterization",totalDownloads:4165,totalCrossrefCites:2,totalDimensionsCites:4,abstract:null,book:{id:"1550",slug:"stratigraphic-analysis-of-layered-deposits",title:"Stratigraphic Analysis of Layered Deposits",fullTitle:"Stratigraphic Analysis of Layered Deposits"},signatures:"Giovanni Leucci",authors:[{id:"106172",title:"Dr.",name:"Giovanni",middleName:null,surname:"Leucci",slug:"giovanni-leucci",fullName:"Giovanni Leucci"}]},{id:"36322",doi:"10.5772/34019",title:"The Paleogene Dinoflagellate Cyst and Nannoplankton Biostratigraphy of the Caspian Depression",slug:"the-paleogene-dinoflagellate-cyst-and-nannoplankton-biostratigraphy-of-the-caspian-depression",totalDownloads:2396,totalCrossrefCites:2,totalDimensionsCites:4,abstract:null,book:{id:"1550",slug:"stratigraphic-analysis-of-layered-deposits",title:"Stratigraphic Analysis of Layered Deposits",fullTitle:"Stratigraphic Analysis of Layered Deposits"},signatures:"Olga Vasilyeva and Vladimir Musatov",authors:[{id:"98322",title:"Dr.",name:"Olga",middleName:"N.",surname:"Vasilyeva",slug:"olga-vasilyeva",fullName:"Olga Vasilyeva"},{id:"136891",title:"Dr.",name:"Vladimir",middleName:null,surname:"Musatov",slug:"vladimir-musatov",fullName:"Vladimir Musatov"}]},{id:"36325",doi:"10.5772/35219",title:"Sedimentary Tectonics and Stratigraphy: The Early Mesozoic Record in Central to Northeastern Mexico",slug:"sedimentary-tectonics-and-straigraphy-the-early-mesozoic-record-in-central-to-northeastern-mexico",totalDownloads:2590,totalCrossrefCites:0,totalDimensionsCites:4,abstract:null,book:{id:"1550",slug:"stratigraphic-analysis-of-layered-deposits",title:"Stratigraphic Analysis of Layered Deposits",fullTitle:"Stratigraphic Analysis of Layered Deposits"},signatures:"Jose Rafael Barboza-Gudino",authors:[{id:"103498",title:"Dr.",name:"José Rafael",middleName:null,surname:"Barboza-Gudiño",slug:"jose-rafael-barboza-gudino",fullName:"José Rafael Barboza-Gudiño"}]}],mostDownloadedChaptersLast30Days:[{id:"36319",title:"Orbital Control on Carbonate-Lignite Cycles in the Ptolemais Basin, Northern Greece - An Integrated Stratigraphic Approach",slug:"orbital-control-on-carbonate-lignite-cycles-in-the-ptolemais-basin-northern-greece-an-integrate",totalDownloads:2725,totalCrossrefCites:1,totalDimensionsCites:3,abstract:null,book:{id:"1550",slug:"stratigraphic-analysis-of-layered-deposits",title:"Stratigraphic Analysis of Layered Deposits",fullTitle:"Stratigraphic Analysis of Layered Deposits"},signatures:"M.E. Weber, N. Tougiannidis, W. Ricken, C. Rolf, I. Oikonomopoulos and P. Antoniadis",authors:[{id:"104271",title:"Dr.",name:"Michael E.",middleName:null,surname:"Weber",slug:"michael-e.-weber",fullName:"Michael E. Weber"}]},{id:"36325",title:"Sedimentary Tectonics and Stratigraphy: The Early Mesozoic Record in Central to Northeastern Mexico",slug:"sedimentary-tectonics-and-straigraphy-the-early-mesozoic-record-in-central-to-northeastern-mexico",totalDownloads:2589,totalCrossrefCites:0,totalDimensionsCites:4,abstract:null,book:{id:"1550",slug:"stratigraphic-analysis-of-layered-deposits",title:"Stratigraphic Analysis of Layered Deposits",fullTitle:"Stratigraphic Analysis of Layered Deposits"},signatures:"Jose Rafael Barboza-Gudino",authors:[{id:"103498",title:"Dr.",name:"José Rafael",middleName:null,surname:"Barboza-Gudiño",slug:"jose-rafael-barboza-gudino",fullName:"José Rafael Barboza-Gudiño"}]},{id:"36321",title:"Pliocene Mediterranean Foraminiferal Biostratigraphy: A Synthesis and Application to the Paleoenvironmental Evolution of Northwestern Italy",slug:"pliocene-mediterranean-foraminiferal-biostratigraphy-a-synthesis-and-application-to-the-paleoenviro",totalDownloads:2735,totalCrossrefCites:5,totalDimensionsCites:13,abstract:null,book:{id:"1550",slug:"stratigraphic-analysis-of-layered-deposits",title:"Stratigraphic Analysis of Layered Deposits",fullTitle:"Stratigraphic Analysis of Layered Deposits"},signatures:"Donata Violanti",authors:[{id:"103001",title:"Prof.",name:"Donata",middleName:null,surname:"Violanti",slug:"donata-violanti",fullName:"Donata Violanti"}]},{id:"66289",title:"Chemostratigraphy of Paleozoic Carbonates in the Western Belt (Peninsular Malaysia): A Case Study on the Kinta Limestone",slug:"chemostratigraphy-of-paleozoic-carbonates-in-the-western-belt-peninsular-malaysia-a-case-study-on-th",totalDownloads:657,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The Peninsular Malaysia is divided into Western, Central, and Eastern tectonostratigraphic belts based on major geological and geophysical phenomena. The Kinta Limestone is a Paleozoic succession located within the Western Belt. Due to structural and tectonothermal complexity, the sedimentological and paleontological works in these carbonates have proven to be problematic unless combined with geochemical approach. Thus, the current study has integrated stratigraphical, sedimentological, and geochemical studies to assess the lithofacies variations and to interpret the depositional environments. An intensive fieldwork has been carried out in order to assess the extent of metamorphism and to locate the less altered sections for further studies. Three boreholes have been drilled on N-S transect of the Kinta Valley recovering a 360 m core. The core description, the mineralogical analysis, and the geochemical analyses including major and trace elements and organic carbon contents have allowed for a significant advancement of the knowledge existing on this basin. The obtained results have indicated that the Kinta Limestone is chiefly composed of carbonate mudstones, siltstones, shales, and minor cherty units. It preserves the main sedimentary features from metamorphism, especially in the northern part of the Kinta Valley. The detrital siliciclastic debris is minimum in the limestones. The overall dominance of fine-grained textures, the lacking of detrital siliciclastic deposits, presence of bedded cherts, and high organic carbon content outlined by geochemistry and the occurrence of uncommon benthic fauna have suggested the deposition in a slope environment with low energy and low oxygen content. The lithological changes from carbonate to siliciclastic deposits have outlined the occurrence of sea level fluctuations in the Paleozoic. The various analyses combined with chemostratigraphy, an independent of type locality and stratotype, enable to interpret the depositional environment of the Kinta Limestone. Thus, it can be useful to correlate to other formations in or similar types of basins in the southeast Asia.",book:{id:"7392",slug:"new-insights-into-the-stratigraphic-setting-of-paleozoic-to-miocene-deposits-case-studies-from-the-persian-gulf-peninsular-malaysia-and-south-eastern-pyrenees",title:"New Insights into the Stratigraphic Setting of Paleozoic to Miocene Deposits",fullTitle:"New Insights into the Stratigraphic Setting of Paleozoic to Miocene Deposits - Case Studies from the Persian Gulf, Peninsular Malaysia and South-Eastern Pyrenees"},signatures:"Haylay Tsegab and Chow Weng Sum",authors:null},{id:"36324",title:"Paleocene Stratigraphy in Aqra and Bekhme Areas, Northern Iraq",slug:"paleocene-stratigraphy-in-aqra-and-bekhme-areas-northern-iraq",totalDownloads:3796,totalCrossrefCites:0,totalDimensionsCites:2,abstract:null,book:{id:"1550",slug:"stratigraphic-analysis-of-layered-deposits",title:"Stratigraphic Analysis of Layered Deposits",fullTitle:"Stratigraphic Analysis of Layered Deposits"},signatures:"Nabil Y. Al-Banna, Majid M. Al-Mutwali and Zaid A. Malak",authors:[{id:"105926",title:"Prof.",name:"Nabil Yousif",middleName:"Yousif",surname:"Al-Banna",slug:"nabil-yousif-al-banna",fullName:"Nabil Yousif Al-Banna"},{id:"111588",title:"Prof.",name:"Majed",middleName:null,surname:"Al-Mutwali",slug:"majed-al-mutwali",fullName:"Majed Al-Mutwali"},{id:"111590",title:"Dr.",name:"Zaid",middleName:"Abdulwahab",surname:"Malak",slug:"zaid-malak",fullName:"Zaid Malak"}]}],onlineFirstChaptersFilter:{topicId:"656",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. 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His later study in cooperation with experts in nephrology and immunology resulted in the designation of the new diagnostic method of UTI, patented in 2017. He is currently working at the Department of Microbiology, Medical University of Gdańsk (GUMed), Poland. Since many years, he is a member of steering committee of Gdańsk branch of Polish Society of Microbiologists, a member of ESCMID. He is also a reviewer and a member of editorial boards of a number of international journals.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorTwo:{id:"484980",title:"Dr.",name:"Katarzyna",middleName:null,surname:"Garbacz",slug:"katarzyna-garbacz",fullName:"Katarzyna Garbacz",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003St8TAQAZ/Profile_Picture_2022-07-07T09:45:16.jpg",biography:"Katarzyna Maria Garbacz, MD, is an Associate Professor at the Medical University of Gdańsk, Poland and she is head of the Department of Oral Microbiology of the Medical University of Gdańsk. She has published more than 50 scientific publications in peer-reviewed journals. She has been a project leader funded by the National Science Centre of Poland. Prof. Garbacz is a microbiologist working on applied and fundamental questions in microbial epidemiology and pathogenesis. Her research interest is in antibiotic resistance, host-pathogen interaction, and therapeutics development for staphylococcal pathogens, mainly Staphylococcus aureus, which causes hospital-acquired infections. Currently, her research is mostly focused on the study of oral pathogens, particularly Staphylococcus spp.",institutionString:"Medical University of Gdańsk, Poland",institution:null},editorThree:null},{id:"4",title:"Fungal Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",isOpenForSubmission:!0,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null},{id:"5",title:"Parasitic Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",isOpenForSubmission:!0,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null},{id:"6",title:"Viral Infectious Diseases",coverUrl:"https://cdn.intechopen.com/series_topics/covers/6.jpg",isOpenForSubmission:!0,editor:{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. 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