Summary statistics of the number of iterations of the EM,
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"2090",leadTitle:null,fullTitle:"Induction Motors - Modelling and Control",title:"Induction Motors",subtitle:"Modelling and Control",reviewType:"peer-reviewed",abstract:"Motivated by the need of energy-efficiency improvements, process optimization, soft-start capability and numerous other environmental benefits, it may be desirable to operate induction motors for many applications at continuously adjustable speeds. The induction motor drives can provide high productivity with energy efficiency in different industrial applications and are the basis for modern automation. This book provides an account of this developing subject through such topics as modelling, noise, control techniques used for high-performance applications and diagnostics. 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From 1987 to 1988, he was an Electrotechnical Engineer in Project Department, Adira Company, Porto, Portugal, and from 1988 to 1989, he was researcher with INESC, Porto, Portugal. Since 1989, he has been with the University of Porto, where he is currently an Assistant Professor with the Department of Electrical and Computer Engineering, Faculty of Engineering, University of Porto. 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We should first define our terms. The phrase ‘risk management’ will refer primarily to the risk of life and limb of human beings, present and future and to the life and health of the planet. Secondarily, it will refer to the taking of risk with the possessions, e.g., the wealth of human beings. For the most part, the discussion will refer to the primary sense of the term and only occasionally in special contexts, to the second. It should be pointed out, at the outset, that the phrase ‘risk management’ is already biased in favor of risk. The phrase implies that the taking of risk is either necessary and/or advantageous and if it carries any negative consequences, these consequences can be mitigated or eliminated by proper management. This bias toward risk is assumed in the acceptance of the use of the phrase ‘risk management’. A major purpose of this investigation is to call into question this built-in bias toward risk.
In the strictest sense, the proper reference for the inquiry should be ‘risky decision taking’ or ‘risky decision making’ rather than ‘risk management’. Such a refining of the subject of inquiry would make the concept of risk either neutral or questionable since the ‘taking’ of risk implies negative consequences whilst ‘risk management’ carries with it the hidden meaning that risk is already being protected against or absorbed by effective management policies. The phrase ‘risk management’ grants risk a protective coating such that the consequences of the risk are camouflaged. As a result, the following discussion will focus primarily on the entire question of ‘taking risk’ or making ‘risky decisions’ in the first place and only secondarily with the ‘management of risk’. For the sake of convenience, in general we will employ the term ‘risk taking’ as a short-hand for ‘risky decision making’ which will always stand for ‘risking the consequences to the principal risk takers as a result of decision making’. The phrase ‘principal risk takers’ refers to those whose lives will be affected by the occurrence of the risk, the primary actors who will be directly involved in taking the risk in the risky situation; e.g., in the case of the Challenger, the astronauts and civilians aboard rather than the ‘decision makers’, the four middle managers. It is gratifying to learn that the U.S. government is currently teaching the terms and definitions for the proper understanding of risk management that the author of this chapter originated that are at the basis of the ideas in this chapter in its educational training courses for FEMA, the Federal Emergency Management Association.
In the specific case from which we will draw most of our information and discussion, the launching of the U. S. space shuttle,
The ethical issues involved in the decision to launch were further nullified by the choice of terminology utilized to classify the level of risk involved in the malfunction of the part that eventually did malfunction (the O-ring). The label utilized was criticality 1, the definition of the consequence of its occurrence being, loss of mission and life. When one of the four managers who overrode the unanimous decision of 14 engineers and managers not to launch was asked at the Presidential Commission hearings, whether the phrase ‘loss of mission and life’ had a negative connotation, the answer given by the manager, Larry Mulloy, was that such a description had no negative connotation and simply meant that you have a single point failure with no back-up and the failure of that single system is catastrophic. Richard C. Cook, Challenger Revealed, An Insider’s Account of How the Reagan Administration Caused the Greatest Tragedy of the Space Age, New York: Avalon, 2006, p. 243. Without Richard Cook’s early articles in the New York Times, it is possible that the entire Challenger investigation would not have occurred. It was a source of inspiration to be in communication with Richard Cook at the time of my writing the Challenger chapters in my book, Saving Human Lives: Lessons in Management Ethics.
The reaction of Richard Cook, the budget analyst at the time, shows how the language of choice removes ethical considerations from one’s consciousness:
How extraordinary: possible “loss of mission and life” doesn’t have a negative connotation. Ibid.
Cook goes on to say that there was no negative connotation because it had been deemed an acceptable risk and, moreover, there had never been any criteria for defining an “acceptable risk”. This was a result of using a failure modes effects analysis without any quantitative risk measures. In other words, the odds of the risk of a catastrophe occurring to the Challenger, were conjured out of thin air, not calculated, because it was a subjective engineering judgment that was not based upon any previous performance data.
Three conclusions present themselves. Firstly, there must exist considerable ethical blindness when loss of life has no negative connotation. Secondly, there must be considerable ethical blindness when loss of life is somehow considered an acceptable risk. Thirdly, there must be considerable epistemological blindness when a notion of “acceptable risk” can be in use without being based on any objective measurements. Cook, one of the few if not the only source on the Challenger who goes into detail on this point, points to one study, conducted in 1984, which concluded that the chance of a Solid Rocket Booster explosion was one in thirty-five launches. Ibid., p. 356.
In 1977, NASA commissioned a group called the Wiggins Group to study the possibility of flight failures and by examining data for all previous space launches, a likely failure rate of one in fifty-seven was derived. According to Cook, NASA complained that many of the launch vehicles the Wiggins group included were not similar enough to the Ibid., pp. 126-7.
An important distinction to keep in mind when considering the whole question of risk taking is the distinction between the likelihood of the occurrence of the risk under question versus the harmful consequence of the actual occurrence of risk under question. Clearly, when the likelihood of occurrence is high and the consequence of occurrence severe in terms of harm doing to risk takers, be it the public at large and/or the environment, this is an example of the kind of risk that should never be taken except under the most severely warranted circumstances. The example of self-defense, when confronted with a murderer who is armed and plans to murder you, comes to mind. Here, the likelihood that your defense will result in his escalating his response is very high, and the consequence of his escalation, in the hypothetical circumstance, could prove to be fatal. Nevertheless, in order to protect your own life, you must take the risk of self-defense under these circumstances.
There is no need to consider the case in which the incidence of occurrence is low and the consequence is also low. For the sake of convenience, whenever the term ‘consequence’ is used it is understood that what is meant is ‘harmful consequence’ to primary risk taker, general public, the environment, future generations or all of the above.
We also need not consider the kind of risk that involves little consequence even if the possibility of its incidence is high. For example, when we carry a glass of milk across the floor, we may easily spill some milk. But, the consequence of the spill (excepting the scenario that we or the person to whom we are carrying the milk are starving) is of no great import. Our discussion need not include examples of high risks of incidence that involve harmless consequences.
The kind of risk with which we most frequently struggle is the risk in which the incidence of its occurrence is low, but the consequence of its occurrence is grave. The example of an airplane exploding in mid-air is a good example of this type of risk. We assume in the state of technology that currently exists commercial air travel is an advantage that we do not wish to surrender. We also know that in the general, unknown risk category, that a plane may explode in mid-air. This risk taking is minimized by careful and regular inspection of the mechanical parts of the airplane and a replacement of said parts and said plane on a needful basis. Other aspects of this risk are minimized by guarding against a drunken pilot, hijacking by suicidal terrorists, etc. In such cases, risk is minimized. It is more accurate to consider that the risk in these cases is
We assume, as an ethical premise, that there should never be a risk taken to potential life and limb unless it is absolutely necessary. A good example of this would be the Hippocratic Oath taken by physicians which begins with the axiom: ‘
What about cases of advantage rather than absolute necessity? For example, let us again consider the case of commercial airplane travel. There is certainly risk involved and it would seem to be the case that the concept of risk management would come into play. Upon closer examination, however, when one considers the safety precautions that are taken through mechanical inspection, etc., one realizes that it is ‘risk taking’ that is modified, that is, one is reducing the risk involved, rather than “managing” an existing risk.
There is a confusion that is frequently made between general and unknown risk that is operative in the universe and any specific risk that is known in advance to exist. For example, whenever one gets out of one’s bed in the morning, one may trip, fall, crack one’s skull and have a concussion. This is the general and unknown risk that is operative in the universe. We should not construe risk in these terms as this kind of risk exists, for the most part, outside of human control and intervention.
Risks that are foreknown in advance to the principals involved in the risk-taking are the only kind of risks that our discussion should consider. A classic case in point of the contrast that exists between general, unknown risk and specifically foreknown risk is the case of the faulty and dangerous O-rings that were known in advance to exist (by managers and engineers though not by the principal risk takers) prior to the fatal flight of the space shuttle
One can argue, fallaciously, that whenever an astronaut goes into space, that astronaut is subject to that general, unknown, universal-style risk of space travel. This, however, is not comparable to an astronaut going into space equipped with the full knowledge of the existence of a real, specific and pre-existing mechanical fault that could be potentially fatal to her or his space craft. It is only with the latter kind of known risk, known fully to those taking the risk, that a discussion on risk management should focus. Such was not the case with the astronauts and civilian passengers of the U.S. space shuttle,
In the case of the Robert Elliott Allinson, Saving Human Lives, Lessons in Management Ethics, Dordrecht: Springer, 2005, p. 156.
Claus Jensen writes in Ibid., p. 184.
Chairman Rogers raised the question of whether any astronaut office representative was aware [of the O-ring problem]’ Weitz, [an astronaut’s representative] answered: “We were not aware of any concern with the O-rings, let alone the effect of weather on the O-rings. Ibid., pp. 184-5, 187.
Despite the very clear declarations above, nowhere in the 575 pages of Diane Vaughan’s book, Ibid., p. 187.
All of the above clearly points to the fact that the objection that one always takes a general, unknown existential risk in life and is aware of this fact is irrelevant whenever there is a specifically foreknown risk that carries with it great and unfortunate consequence. These points make a further argument to support the case that the very notion of risk management needs to be replaced with the idea of risk taking when a known risk carries with it a high probability of life and death danger and there is nothing crucial to be gained by taking such a risk, such a risk is never “managed”, such a risk is never
In the classic case of the space shuttle Challenger example, two years after the horrific event, when the official, U. S. government committee on Shuttle Criticality, Review and Hazard Analysis examined the risk that had been taken in launching the Challenger, the Chairman of that committee wrote in the very first paragraph of chapter four of their report, entitled ‘Risk Assessment and Risk Management’:
Almost lost in the strong public reaction to the Challenger failure was the inescapable fact that major advances in mankind’s capability to explore and operate in space – indeed, even in routine, atmospheric flight – will only be accomplished in the face of risk.
And, later, in the body of that same report, the Committee wrote: ‘The risks of space flight must be accepted by those who are asked to participate in each flight … Preface by Alton Slay, Chairman, Committee on Shuttle Criticality, Review and Hazard Analysis, Post-Challenger Evaluation of Space Shuttle Risk Assessment and Management, Washington, D.C.: National Academy Press, 1988, p. v; p. 33.
It is rather easy to spot the fallacy that is being made in this case. It is the fallacy of equating a general unknown risk (space flight in general) with a specifically foreknown fatal risk (the flawed design of the O-rings about which the senior engineer Roger Boisjoly had issued red flagged warnings). Robert Elliott Allinson, Saving Human Lives, Lessons in Management Ethics, Dordrecht: Springer, 2005, p. 138.
When one examines the
The O-ring design of giant rubber gaskets keeping combustible hot gases from leaking out, in actual fact, ranked fourth out of four submitted engineering designs and, according to an important article co-written by Trudy Bell, Senior Editor of the engineering journal, Robert Elliott Allinson, ‘Risk Management: demythologizing its belief foundations,’ International Journal of Risk Assessment and Management, Volume 7, No. 3, 2007, p. 302.
There was also no need to choose a design for the space shuttle that did not include an abort system, that is explosive bolt hatches, space pressure suits and a parachute descent system. That it did not include such a safety system was a matter of policy, not impossibility since earlier spacecraft had been equipped with launch escape systems. Again, nowhere, in any place, in the 575 pages of Ms. Vaughan’s, Op. cit., pp. 188-189.
The above examples make it clear that the problem of risk lies in the
One can look into the matter in more detail. Suffice it to say for the present discussion and analysis that there were two levels of risk taking that were matters of choice, not management. The first level was the choice of design. The choice of design could have been altered to have prevented the breaking apart of the space shuttle. The choice of the design could have been altered to prevent the death of the crew and passengers. It was design
There has been much erroneous discussion of the technical issues of the temperature and the O-rings and as a result, massive misconceptions have created complicated layers of confusion around the issue. The mass of confusion surrounding the technical issues is, to the best of this author’s knowledge, discussed in proper factual detail in the two chapters on the Challenger disaster in the author’s Saving Human Lives, Lessons in Management Ethics (now in Kindle and Google Books). The author is indebted to extensive private correspondence with Roger Boisjoly for clearing up the confusion about the technical issues that made understanding the Challenger issues murky and seemingly resistant to plain understanding. To the best of the author’s knowledge, such clear explanations that Boisjoly gives, sorting out the mistakes in previous analyses of the Challenger disaster such as in Diane Vaughan’s confused studies on the issue only exist in print in the author’s Saving Human Lives. Cf., especially Chapter Seven, ‘The Space Shuttle Challenger Disaster,’ and Chapter Eight, ‘Post-Challenger Investigations’, pp. 107-197.
According to Roger Boisjoly, the senior scientist at NASA and the one who knew the most about the O-rings, she routinely mixed up data relating to field joints and nozzle joints and did not have a clue about the difference between the two joints. Saving Human Lives, pp.192-3 et passim. Ibid., p. 192. (emphasis his) Ibid., pp. 172-3. The author of this chapter was gratified when he personally received a hand-written letter written to him by the famous sociologist David Riesman from Harvard, author of The Lonely Crowd, who wrote to commend the merits of this author’s first review of Diane Vaughan’s book, The Challenger Launch Decision: Risky Technology, Culture and Deviance at NASA, which was to come out in Society . Later, he was prompted by this author’s second review, which took a very different tack, and which appeared in Business Ethics Quarterly to read her book after which he wrote to this author to say that Diane Vaughan’s book was simply, in his words, ‘a bad book’.
We can point to three elementary characteristics of warning signals to illustrate that the risk was foreknown and knowledge of it was transmitted: The three characteristics of warning signals. To focus on risky technology is to put the cart before the horse. Risky choice is the horse: it pulls the technology along behind it. Without the horse, the cart would not move. Technology has no power on its own. It is the servant of decision making 10 14-15.
In the case of the The hypothesis of “weak signals” to describe the warnings of the failure of the O-rings was put forward by Diane Vaughan in her book, The Challenger Launch Decision: Risky Technology, Culture and Deviance at NASA.
This “weak signals” hypothesis is easily refuted when one considers the
The Op. cit., p. 170.
Finally, the
It should be noted that this signal was not a one-time occurrence. Ibid., p. 151.
In terms of, in terms of the form of the “weak signals” hypothesis, it should be noted that when it came to the timing of the launch, 14 managers and engineers alike unanimously voted against it. Ibid., pp. 174, 195. Ibid., for an extended analysis of the unsound and unethical decision making process engaged in by the four middle managers.
It should be emphasized that the Committee on Shuttle Criticality, Review and Hazard Analysis did not focus on the life and death consequences to the principals involved in taking the risk of launching the Challenger, but rather focused on the general, abstract case of space flight as an opportunity for learning about the universe. In short, they examined a “straw man” and not the real case in front of them to examine.
In the case of the red-flagged warnings, regarding the launching of the
The first straw man was to examine the case as if all aboard were astronauts. This assertion was contrary to fact. Not every person aboard the shuttle was an astronaut. In addition to the five astronauts, one of whom was a female, Judith Resnik, there were two passengers: one, a junior and high school teacher, a 37 year old mother of two, Christa McAuliffe and the other, Greg Jarvis, an engineer from Hughes Aircraft (not a member of the Astronaut Corp) who had been given a ride in a space flight as a prize for winning a company competition. Mrs. McAuliffe was scheduled to deliver a nationwide “lesson from space” called the “Ultimate Field Trip” to the nation’s school children. She was also supposed to receive a telephone call from President Reagan in mid-flight.
Part of the consequences, then, was the risk of the death of two civilians, who were there, not to operate the space craft, but one to act as a Teacher in Space and the other to claim his contest prize. Both civilians were given the deceptive, camouflage designation of “payload specialists” that implied some kind of crew responsibilities that did not exist. For a cover, Mr. Jarvis was given the task of conducting a fluid dynamics experiment and Mrs. McAuliffe was to videotape six science demonstrations of the effects of weightlessness on gravity, etc. Richard C. Cook, Challenger Revealed, An Insider’s Account of How the Reagan Administration Caused the Greatest Tragedy of the Space Age, New York: Avalon, 2006, pp. 177-8.
The second straw man argument is to assume that knowing the risk of space flight in general was equivalent to knowing the risk of a launch under weather conditions that were known to be unsafe with the O-ring technology in use. Again, neither the astronauts nor the two civilians aboard were made aware of the risk that they were taking. They may have been aware of the existential, general unknown risk of space exploration, but they were not aware of the specific, needless risk they were actually committing to take by being launched into space with a known, faulty technology. Op. cit.., p. 156.
Was Mrs. Christa McAuliffe made aware of the risk that she was taking? Grace Corrigan wrote:
With respect to the Challenger launch, ‘ … Christa felt no anxiety about the flight. ‘I don’t see it as a dangerous thing to do.’ She said, pausing for a moment. ‘Well, I suppose it is, with all those rockets and fuel tanks. But if I saw it as a big risk, I’d feel differently.’ Grace George Corrigan, A Journal for Christa, Christa McAuliffe, Teacher in Space, Lincoln and London: University of Nebraska Press, 1993, pp. 115, 118.
It was not only the case that Christa felt no pre-flight fears. She was never even informed that there was any real problem about which she should have been informed. Corrigan relates Christa McAuliffe’s account of what the President and the pilot from a previous launch told her in the White House:
‘They were told about the dangers of the space program. She said that one could be intimidated thinking of all that he had said until you realize that NASA employed the most sophisticated safety features, and they would never take any chances with their equipment, much less an astronaut’s life.’
When interviewed by Space News Roundup, she said that, ‘When the Challenger had the problem back in the summer with the heat sensors on the engine … and … one of Boston’s papers called me and asked me what I thought was wrong, … I said, ‘I have no idea. What has NASA said?’ Op. cit., p. 185.
It is obvious that Christa McAuliffe was not informed of any O-ring faults and the consequent life and death risk she was engaged and committed to taking by her participation. Is this a case where the statement from the Committee on Shuttle Criticality, Review and Analysis, that ‘The risks of space flight must be accepted by those who are asked to participate in each flight’ is even relevant when no one has been informed about the specific risks to which this particular flight will be prone? The fallacy of conflating the general, unknown risks of space flight with the specifically known risks of this flight makes “risk management” here into an unethical practice. There is, strictly speaking, no risk management that is being practiced. There is simply a wanton risk taking with human life.
The Nobel laureate physicist, Richard Feynman was shocked to learn that NASA management had claimed that the risk factor of a launch crash was 1 in 100,000 which they had arrived at through a subjective engineering judgment without relying upon any actual past performance data. If one calculated risk based upon actual past performance data, the risk was, according to Professor Feynman, 1 in 100. Ibid., p. 183.
From the above example, one can generate the conclusion that whenever possible, when calculating risk, one should not calculate risk in any other way than from the conclusions generated from actual, real-life, past performance data. The lesson to be learned is that in risk assessment, past performance data, when available, must always be consulted. One should avoid guess work. Unless the risk estimates are based on past performance data as a data base, according to Professor Feynman, ‘it’s all tomfoolery’. Ibid., p. 183.
Major General Kutnya, Director of Space Systems and Command Control, USAF, and Presidential Commission member, argued that the O-ring evidence was analogous to evidence that an airliner wing was about to fall off. Professor Feynman pointed out with respect to Diane Vaughan’s contention that there was a ‘safety factor of three’, that because in previous cases, the O-ring had burned only one third of the way through, that did not prove that there was a safety factor of three. If we merge the O-ring and the airplane wing examples, the argument that General Kutnya, an Air Force General and Professor Feynman, a Professor of Physics, give is that if the wings of an aircraft have burned one-third of the way through, that did not mean that they had a two-thirds safety margin as Diane Vaughan, a sociologist with a Masters Degree in Sociology, thinks. If a part that is designed to hold back inflammatory gases is weakened by one-third, then its capacity to hold those gases back is diminished by one-third. In such a weakened state, the margin between its holding up and its caving in to the pressure of the gases is seriously undermined. It is not that it possesses a two-thirds safety margin; it is that one-third of its capacity is diminished. It may not be capable of standing up to a heavy load. Its safety margin at that point may be zero.
In Professor Feynman’s words:
If a bridge is designed to withstand a certain load … it may be designed for the materials used to actually stand up under three times the load … But if the expected load comes on to the new bridge and a crack appears in a beam, this is a failure of the design. The O-rings of the solid rocket boosters were not designed to erode. Erosion was a clue that something was wrong. Erosion was not something from which safety could be inferred.’ Ibid., p. 183.
If we are to generalize from these arguments to future scenarios of risk assessment, we must be careful never to consider problems that develop as evidence that the design is still basically sound. Problems are danger signals, not signals that everything is fine. When safety is compromised, it does not signify that there is still a viable margin of safety. When safety is weakened, what we have left is not a state of safety conditions which are a little less than perfect; we have conditions which are not safe.
One must also be very careful when one considers safety back-ups. In engineering language, safety back-ups are referred to as redundancies. (It is important to take note of the difference in English language usage in the case of technical engineering terms and ordinary English language usage since, in the latter case, a redundancy is that which is unnecessary!) In the case of the Challenger, the back-up system was a secondary O-ring seal. The secondary seal was known also to be prone to failure. In effect, there was no secondary seal. Of course, if we are to consider the argument made above carefully, if the primary seal is unsafe, and the secondary seal is made from the same materials with the same design, how is it any safer? When examining any safety back-ups, one must be certain that the back-ups are not of the same faulty design as the technology that they are supposedly “backing-up”. Since the O-ring was considered to be at Criticality 1 (no back-up), it is thus not suprising that the secondary seal was not considered to be a back-up by this designation.
In addition, it must not be forgotten that initially all 14 engineers and managers unanimously voted against launching the Challenger. Such a vote of no confidence would be proof enough that all 14 engineers and managers had no confidence in the secondary seal. If, when Professor Feynman in his famous, improvised experiment during the televised hearings dropped a piece of the rubber O-ring into a glass of ice water obtained from a waiter, and demonstrated that it had no resiliency left to it at a freezing temperature and therefore could not expand to contain superhot inflammable gases, how would a second piece of the same rubber material be of any use? If one piece of rubber would not seal, why would another piece of the same rubber not also be stiff? Ibid., p. 171.
As a final point in the question of risk taking, we must consider what gives any person or group of people the right to make decisions which will have life and death consequences for those who partake in the actions that will take place as a result of that decision-making. It has been argued that astronauts already knew the risks of space travel when they undertake such an adventurous role. Again, this is to confuse the general unknown risk of space travel with the specifically foreknown risk of launching with an unsafe part. It is also to ignore the fact that two civilians were aboard in addition to the five astronauts.
What if we consider the question of decision making over life and death when the one involved is oneself? Suppose, for example, the astronauts and the civilians had been told of the dangers. It is entirely possible that the astronauts would still have chosen to launch. Even if the decision were placed in the hands of the Captain of the astronauts on that launch and he was fully informed of the dangers, should he have the right to decide if the launch should proceed? In a war, a general does decide if troops should engage in battle. There, of course, there may be a set of circumstances when something very valuable (the lives of one’s countrymen for example) must be protected. But, here, we are still considering the scenario where there is nothing great to be gained – such as protecting one’s countrymen from destruction - by proceeding with the timing of this launch..
What if we leave the decision to launch to the astronauts themselves and make sure that they are fully informed of the dangers? (For the sake of this discussion, we except the case that there are two civilian passengers aboard). The crew, who perceive themselves as heroes, are likely to decide to vote to launch. When the author had the privilege to personally interview Kathyrn Cordell Thornton, the celebrated astronaut who was part of the 100 strong astronaut corps at the time of the Challenger, and then Director of the Center for Science, Mathematics and Engineering Education at the University of Virginia, and the author of this chapter was privileged to be accompanied in this interview by the distinguished business ethicist, Patricia Werhane, we discussed this very issue. The author of this chapter vividly recalls Thornton saying that, ‘if these astronauts had refused to go up, there would be 100 others behind them waiting to take their place.’ This is not surprising when one considers the peer expectations of that kind of group. There is a psychological expectation that they should be fearless. This is no different from football players going into the field with a head injury. The question now has become, does one have a right to take a risk with one’s own life? One could say that this is a matter of individual choice. But, is it?
One can consider the choice of a circus performer who decides to risk her or his life by performing on a high wire with no safety net. Should this be a matter of individual choice? Suppose the circus performer has overestimated her or his abilities? Again, the possibility of the incidence may be low, but the consequences are fatal. The performer is placing a greater value on the spectacle value of a performance without safety than on the value of her or his life. Should such a decision be left in the hands of an individual performer? Or, should such a decision be overridden, if necessary, by the director of the circus?
Do we ever have a right to make life and death decisions that affect our own life and death? Or, is the value of life so precious that it should never be risked unless there is an absolute necessity? If we take the latter position, no one has the right to take such a risk with one’s own life except under the conditions of absolute necessity; e.g., as in the case of self-defense.
The case becomes more clear when we consider the circumstance of intended suicide. Assuming a situation in which the intended is not the victim of an incurable disease and is not making a forced choice (such as when a Nazi may say to a Jew, ‘Kill yourself now or I will kill your child’), does anyone have a right to gratuitously take her or his own life? While it may be thought that this is still a matter of individual choice and one can point to the custom of ancient Romans and Japanese in this regard, one must remember that in the case of ancient Rome and Japanese tradition, it was a case of personal honor and not merely gratuitous. In the case of the ancient Romans and the Japanese, these honorable suicides were not sanctioned because the individuals involved were desperately unhappy with their lives.
In the case of the astronauts – leaving aside the civilians, the secondary school teacher and the journalist who have no such honor code –
Ultimately, the deciders, those who are taking the risk of other people’s lives in their own hands, have the responsibility of
We should not leave the discussion of this one classical example without reiterating that the astronauts and the civilians aboard could have easily been provided with proper space suits, parachutes and ejection chairs. No one died as a result of the explosion. Horrifically, all died because of too fast a collision with the ocean. All were breathing until ocean contact. Ibid., p. 188. Ibid.
Classic examples of risk management would appear to be the actions of fund managers. Under the arguments advanced above, if one likens one’s funds as the means to one’s livelihood, one should never take risk with other people’s money. While this would appear to be impossible without doing away with capitalism altogether, there is one interesting counter example that should give pause to one’s thought. There is one hedge fund company on Wall Street that guarantees any loss of any client’s investment up to four million US dollars. Cf., Peter Lattman and Jenny Anderson, ‘For 92nd St. Y, a Break from Wall Street Worry,’ NY Times, November 29. 2011. In this article, this guarantee is offered by the hedge fund manager, John A. Paulson.
Before departing from this topic, we must address an objection commonly brought forth, which in the designation of the author may be labeled, the ‘Hindsight Objection’. The following is the ‘Hindsight Objection’. There are always warnings of disasters and they are commonly ignored. When no disaster occurs, these warnings are forgotten. If one went back to every successful venture; e.g. a space flight, one would find the ignored warnings. Therefore, if one infers from warnings that an unsuccessful flight occurred, one is inferring from unwarranted premises. Whenever one goes back and traces the causes of disasters to unheeded warnings, one is justifying warnings through hindsight which is always 20-20. Hence, the label, the Hindsight Objection.
There are two major replies to this objection. The first reply is that it is entirely hypothetical. In order to make good on the Hindsight Objection, one must bring forth evidence to support it. In other words, one must take a successful venture; e.g., a space flight, and show first of all that there were red-flagged warnings that the flight should not have taken place. If the ‘red-flagged’ designator is not in use, the warnings must be shown to be of high-priority status, i.e., it should be demonstrated that such warnings were equivalent in status to the warnings not to launch disastrous flights, such as the dire warnings that were lodged in the attempt to stop the launch of the Challenger. Warnings must be vetted in terms of the criteria spelled out above, in terms of source, form and content. What is commonly brought forth as “hindsight evidence” in the case of the Challenger are operational parts which are designated as Criticality 1, of which there were many such on the Challenger which did not fail. A Criticality 1 designation indicates that the failure of such a part would result in the loss of the vehicle and human life. But a Criticality 1 designation is not equivalent to a red-flagged warning that the part designated as Criticality 1 was likely to malfunction. One cannot point to parts with a Criticality 1 designation that did not fail as evidence that there were warnings that failure was imminent. A part with a Criticality 1 designation could, theoretically, be extremely safe. To count as a legitimate warning, there must be a specific, high priority (red-flagged) warning concerning the faulty design or operational capacity under certain weather conditions, etc., of a part which possesses a Criticality 1 designation.
This first condition, the prior presence of red-flagged warnings that meet the above criteria in terms of source (knowledgeable expert witness), form (red-flagged), and content (spelling out the specific flaw in the part), to the best of my research and knowledge, have never been met. The Hindsight Objection is always made as a purely hypothetical objection without any evidence for its truth value ever put forth. In the case of space flights (this example is used because it is best known to the author), one must show that there were other launches in which the senior scientist issued repeated red-flagged alerts and all of the engineers and managers voting on the planned launch voted unanimously against the launch. Has anyone ever brought forth any evidence in support of the Hindsight Objection claim?
The second major objection is that even if one could offer an example of a flight which met the equivalent set of warnings that were issued in the case of the Challenger, one might miss the point that such warnings are not intended to be construed to be 100% reliable predictions concerning the particular flight in question. Such warnings are not meant to be on the level not of, if this flight will take place, but of when this flight, or a similar flight, takes place, such a likelihood of such a flight ending in disaster is a horrific eventuality. If the warnings are not justified on the basis of one flight, they might well be on the basis of the third or the seventh flight. When one leaves the auto mechanic’s shop with faulty brakes, the service manager might warn the customer that the brakes may fail. If the brakes do not fail on the first hill, that does not mean that her or his warning was without value. They may fail on the ninth hill. Thus, even if one could find a case in which dire warnings that fit the above criteria were present and the flight or sail went without incident, that would not prove that all such flights were to be considered safe.
It is informative to reflect on the fact that Boisjoly’s warnings cover both the likelihood of the possibility of the
It is therefore worthwhile to consider abandoning the concept of risk management and replacing it with the concept of risk taking. When one removes the euphemism of risk management and replaces it with risk taking, it becomes abundantly evident that it is actual human life with which one is taking risk. One is playing G-d with human life.
Whenever, under whatever circumstances, risk management is being considered, one must first consider whether any risk must be in existence in the first place. In a condition of great advantage, such as commercial air travel, the existence of risk is minimized in the first place. After its minimization, it is not a case of risk management that is practiced as much as it is a case of safety protection. It is not a case of a mere shift in wording, because if we employ the language of safety we will be reminded of the ethical priority of the preciousness of human life (together with its corollaries of future generations and the health of the planet). The risk of airplane travel is minimized with proper attention to mechanical safety, pilot training, etc.
To make a brief shift to another example to ensure that the problems with the concept of risk management are not confined to the case of the
Whatever we do in life, we cannot close our eyes and pretend that we can remove all dangers from any human endeavor. But a step forward can be made if we consider safety protection as our highest priority. In doing so, we must pay attention to the
The idea of “risk management” implies that risk must be present. We must ever guard against complacency. If we keep uppermost in mind that the preciousness of life is our highest priority, we will ensure that the presence of the possible incidence and the consequence of risk is kept at the lowest possible point.
The notion of providing enough safety boats for half of the passengers (the model of the Titanic) fits perfectly into the concept of “managing risk”. When we do this, we have performed some kind of cost-benefit analysis, or, to speak more strictly, some kind of probability-benefit analysis, and have reached a decision that by providing life boats for only half of the passengers we are fulfilling the responsibility of “managing risk”. It is not clear how this decision was reached. Perhaps, it was reached by assuming that only half of the passengers would make it to the life boats, hence, by providing half of the needed boats, we have “managed” the risk.
In conclusion, if we use the language of risk taking, the provision of life boats for half of the passengers on board is still a case of
Ibid., p. 87.
It is hoped that this introduction to the new idea of risk taking as opposed to risk management will create reflection and commitment to a greater ethical sensitivity when we consider how our decision making may affect other people’s lives. Do we ever have a right to take decisions that risk other people’s lives? If the message of this chapter is heard, then we do not ever have the right to risk other people’s lives unless we provide full and adequate protection for the consequences of the risk that we are taking with other people’s lives. If we change our language habits from commonly using the phrase ‘risk management’ to never using this term, but rather replacing it with the phrase, ‘risk taking’, we may have a more ethically responsible world.
Mixture models become increasingly popular due to their modeling flexibility and are applied to the clustering and classification of heterogeneous data, see [1, 2, 3]. The EM algorithm [4] is largely used for the maximum likelihood estimation of mixture models because the algorithm is stable in convergence and simple in implementation. Despite such advantages, it is pointed out that the EM algorithm is local and has slow convergence as the main drawback.
To circumvent the problem of slow convergence of the EM algorithm, various acceleration algorithms incorporating optimization methods are proposed. The optimization methods include the multivariate Aitken method [5], the conjugate gradient method [6], and the quasi-Newton method [7, 8]. However, these methods require matrix computation such as matrix inversion or evaluation of Hessian and Jacobian matrices and a line search for step length optimization. Therefore, their acceleration algorithms tend to lack one or more of the nice properties of the EM algorithm, although they may converge faster than the EM algorithm.
As another approach, the
In application of the EM algorithm to mixture models, the algorithm is sensitive to the choice of the initial value and may find estimates at a local maximum of the log-likelihood function. Several strategies are proposed to efficiently initiate the EM algorithm for getting the global maximum of the log-likelihood function, see [14, 15, 16, 17]. We use the emEM algorithm [14] for the mixture model estimation and improve its computation speed by the
The chapter is organized as follows. Section 2 describes the EM algorithm for normal mixture models. In Section 3, we introduce the
Let
where
Direct maximization of the function (2) is complicated, and then the maximum likelihood estimate (MLE) of
In the setting of the EM algorithm, we regard
Given
and the MLE
for
Mixture models treat
The quantity
The M-step finds
When replacing
From Eqs. (6) and (7), we also have
We describe the EM algorithm for the normal mixture model in Algorithm 1.
In order to accelerate the convergence of the EM algorithm, we can use the
We briefly introduce the v
where
We define the EM algorithm as a mapping
The
Assume that the sequence
The theorems with the convergence and acceleration of the algorithm are given in [18].
As shown in Algorithm 2, the
When this occurs, the EM step is restarted with
By our experiments, the restarting procedure is performed almost every time when we only use the restarting condition
The restarting conditions are summarized as follows:
Condition (i) means that the log-likelihood function can be increased by restarting. Condition (ii) is used to reduce the frequency of restarting. This is the key idea of the restarting procedure. The
update
and reset
The
Theoretical results of convergence and speed of convergence of the
We investigate how much faster the
The R package
Tables 1 and 2 report the results of the number of iterations and CPU time of these algorithms for each
Min. | 1st Qu. | Median | Mean | 3rd Qu. | Max. | ||
---|---|---|---|---|---|---|---|
EM | 172.00 | 467.25 | 771.00 | 1069.48 | 1302.25 | 10852.00 | |
133.00 | 308.50 | 445.00 | 697.74 | 706.50 | 8090.00 | ||
83.00 | 182.50 | 253.50 | 424.22 | 396.50 | 4967.00 | ||
EM | 210.00 | 403.50 | 628.50 | 716.33 | 946.75 | 1973.00 | |
121.00 | 276.75 | 400.50 | 484.83 | 604.75 | 1566.00 | ||
68.00 | 167.50 | 244.50 | 307.99 | 359.75 | 1183.00 | ||
EM | 166.00 | 372.75 | 468.50 | 618.63 | 755.75 | 2193.00 | |
120.00 | 248.75 | 331.50 | 400.00 | 461.50 | 1452.00 | ||
58.00 | 139.00 | 194.50 | 241.25 | 291.25 | 884.00 | ||
EM | 141.00 | 334.75 | 492.50 | 879.35 | 783.00 | 24886.00 | |
101.00 | 235.50 | 351.00 | 687.31 | 516.00 | 24756.00 | ||
57.00 | 144.00 | 226.00 | 431.55 | 336.50 | 14288.00 | ||
EM | 193.00 | 361.25 | 499.00 | 655.80 | 647.75 | 5910.00 | |
144.00 | 252.00 | 323.50 | 454.45 | 473.75 | 5825.00 | ||
99.00 | 163.75 | 230.50 | 302.13 | 299.00 | 4771.00 |
Summary statistics of the number of iterations of the EM,
Min. | 1st Qu. | Median | Mean | 3rd Qu. | Max. | ||
---|---|---|---|---|---|---|---|
EM | 0.39 | 1.04 | 1.68 | 2.31 | 2.80 | 22.73 | |
0.30 | 0.75 | 1.08 | 1.66 | 1.66 | 19.18 | ||
0.22 | 0.49 | 0.66 | 1.11 | 1.04 | 13.21 | ||
EM | 0.75 | 1.40 | 2.07 | 2.64 | 3.30 | 8.53 | |
0.45 | 1.01 | 1.46 | 1.99 | 2.52 | 7.60 | ||
0.35 | 0.68 | 1.00 | 1.44 | 1.68 | 8.26 | ||
EM | 0.42 | 0.93 | 1.16 | 1.53 | 1.86 | 5.34 | |
0.28 | 0.65 | 0.86 | 1.06 | 1.24 | 3.80 | ||
0.20 | 0.44 | 0.59 | 0.71 | 0.86 | 2.39 | ||
EM | 0.25 | 0.64 | 0.92 | 1.65 | 1.50 | 46.11 | |
0.22 | 0.49 | 0.72 | 1.42 | 1.08 | 50.36 | ||
0.16 | 0.35 | 0.51 | 0.95 | 0.80 | 29.07 | ||
EM | 0.51 | 1.02 | 1.42 | 1.84 | 1.88 | 17.86 | |
0.43 | 0.75 | 1.02 | 1.37 | 1.47 | 17.75 | ||
0.32 | 0.54 | 0.76 | 0.99 | 1.00 | 14.29 |
Summary statistics of CPU time of the EM,
To measure the speed of convergence of the EM and two acceleration algorithms, we calculate iteration and CPU time speedups. The iteration speedup of an acceleration algorithm for the EM algorithm is defined by
The CPU time speedup is also calculated similarly to the iteration speedup. Tables 3 and 4 show the results of the iteration and CPU time speedups of two acceleration algorithms. We compare the mean values of the iteration and CPU time speedups of the algorithms. The
Min. | 1st Qu. | Median | Mean | 3rd Qu. | Max. | ||
---|---|---|---|---|---|---|---|
1.05 | 1.34 | 1.54 | 1.61 | 1.77 | 3.58 | ||
1.15 | 2.08 | 2.73 | 3.03 | 3.48 | 11.36 | ||
1.07 | 1.32 | 1.52 | 1.52 | 1.68 | 2.15 | ||
1.20 | 1.97 | 2.57 | 2.58 | 2.98 | 6.08 | ||
1.13 | 1.32 | 1.48 | 1.51 | 1.62 | 2.33 | ||
1.45 | 2.09 | 2.42 | 2.60 | 2.94 | 9.04 | ||
1.01 | 1.30 | 1.46 | 1.47 | 1.63 | 2.06 | ||
1.33 | 1.84 | 2.23 | 2.32 | 2.67 | 4.32 | ||
1.01 | 1.28 | 1.46 | 1.49 | 1.65 | 2.33 | ||
1.24 | 1.86 | 2.17 | 2.37 | 2.59 | 6.75 |
Summary statistics of the iteration speedup of the
Min. | 1st Qu. | Median | Mean | 3rd Qu. | Max. | ||
---|---|---|---|---|---|---|---|
0.97 | 1.22 | 1.45 | 1.47 | 1.67 | 3.37 | ||
1.05 | 1.71 | 2.24 | 2.50 | 2.85 | 8.60 | ||
0.85 | 1.21 | 1.39 | 1.40 | 1.56 | 2.07 | ||
0.78 | 1.61 | 2.04 | 2.08 | 2.40 | 4.48 | ||
1.02 | 1.27 | 1.39 | 1.43 | 1.53 | 2.11 | ||
1.20 | 1.70 | 2.03 | 2.17 | 2.43 | 7.48 | ||
0.92 | 1.17 | 1.33 | 1.34 | 1.50 | 2.06 | ||
1.12 | 1.48 | 1.76 | 1.86 | 2.12 | 3.21 | ||
0.84 | 1.18 | 1.39 | 1.39 | 1.55 | 2.21 | ||
1.00 | 1.57 | 1.77 | 1.98 | 2.24 | 5.47 |
Summary statistics of the CPU time speedup of the
Boxplots of the iteration speedup of the
Boxplots of the CPU time speedup of the
Figure 3 shows the boxplots of the iteration and CPU time speedups of the
Boxplots of the iteration and CPU time speedups of the
The results from the tables and figures demonstrate that the restarting step in the
It is well known that the log-likelihood function (2) may have numerous maximums. The EM algorithm does not guarantee to obtain the global maximum of the log-likelihood function due to its local convergence. Thus, the initial value of
We apply the emEM algorithm [14] to the mixture model estimation. The algorithm is a popular one and usually provides excellent results when the number of components is not large [21]. The emEM algorithm selects an initial value in the em step that is several short runs of the EM algorithm using different initial values and a lax convergence criterion and obtains
The em step consists of three steps. The first step generates
Let
Obtain
The em step performs multiple runs of the EM algorithm, and then its computation may be time-consuming. We replace the EM algorithm with the
Obtain
We evaluate the performance of the
By using MixSim, we simulate
Tables 5 and 6 present the number of iterations and CPU time for each
emEM | |||||||
---|---|---|---|---|---|---|---|
em | EM | total | total | ||||
1912 | 3834 | 5746 | 1415 | 1429 | 2844 | ||
1995 | 1490 | 3485 | 925 | 354 | 1279 | ||
2352 | 725 | 3077 | 997 | 451 | 1448 | ||
3344 | 885 | 4229 | 1516 | 397 | 1913 | ||
2641 | 957 | 3598 | 1234 | 435 | 1669 |
The numbers of iterations of the emEM and
emEM | |||||||
---|---|---|---|---|---|---|---|
em | EM | total | total | ||||
6.04 | 7.37 | 13.41 | 4.67 | 3.22 | 7.89 | ||
6.36 | 3.14 | 9.50 | 3.23 | 1.00 | 4.23 | ||
8.81 | 1.61 | 10.42 | 3.98 | 1.86 | 5.84 | ||
12.55 | 2.33 | 14.88 | 6.04 | 1.19 | 7.23 | ||
11.01 | 2.44 | 13.45 | 5.35 | 1.43 | 6.78 |
CPU times of the emEM and
In this chapter, we introduced the
When the EM algorithm is applied to normal mixture models, the algorithm may converge slowly and be heavily dependent on the initial value. The first problem is solved by the acceleration of the EM algorithm. The numerical experiments indicated the availability of the
The
Let
and then generates a vector
For practical implementation, we apply the v
Then the vector
When setting
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Leite",authors:[{id:"1164",title:"Dr.",name:"Fabio",middleName:"Lima",surname:"Leite",slug:"fabio-leite",fullName:"Fabio Leite"},{id:"136651",title:"MSc.",name:"Ricardo",middleName:null,surname:"De Oliveira",slug:"ricardo-de-oliveira",fullName:"Ricardo De Oliveira"},{id:"136652",title:"M.Sc.",name:"Diego",middleName:"Aparecido Carvalho",surname:"Albuquerque",slug:"diego-albuquerque",fullName:"Diego Albuquerque"},{id:"136653",title:"Prof.",name:"Tersio",middleName:null,surname:"Cruz",slug:"tersio-cruz",fullName:"Tersio Cruz"},{id:"136657",title:"Prof.",name:"Fabio",middleName:null,surname:"Yamaji",slug:"fabio-yamaji",fullName:"Fabio Yamaji"}]},{id:"49054",doi:"10.5772/60952",title:"Anion Exchange Resins as Effective Sorbents for Removal of Acid, Reactive, and Direct Dyes from Textile Wastewaters",slug:"anion-exchange-resins-as-effective-sorbents-for-removal-of-acid-reactive-and-direct-dyes-from-textil",totalDownloads:3184,totalCrossrefCites:24,totalDimensionsCites:47,abstract:"Coloured wastewaters are a consequence of batch processes in both dye-manufacturing and dye-consuming industries. Dyes are widely used in a number of industries, such as textile and leather dyeing, food, cosmetics, paper printing, gasoline, with the textile industry as the largest consumer. Dyeing as a fundamental operation during textile fibre processing causes the production of more or less coloured wastewaters, depending on the degree of fixation of dyes on substrates, which varies with the nature of substances, desired intensity of coloration, and application method. Dye bearing effluents are considered to be a very complex and inconsistent mixture of many pollutants ranging from dyes, dressing substances, alkalis, oils, detergents, salts of organic and inorganic acids to heavy metals.Thus after dyeing wastewaters are characterized not only by intensive and difficult for removal colour but also by high pH, suspended and dissolved solids, chemical and biochemical oxygen demands. Ion exchange is a very versatile and effective tool for treatment of aqueous hazardous wastes including dyes. The role of ion exchange in dye effluents treatment is to reduce the magnitude of hazardous load by converting them into a form in which they can be reused, leaving behind less toxic substances in their places or to facilitate ultimate disposal by reducing the hydraulic flow of the stream bearing toxic substances. Another significant feature of the ion exchange process is that it has the ability to separate as well as to concentrate pollutants. Taking into account high capacity and selectivity of ion exchange resins for different dyes, they seem to be proper materials for dyes sorption from textile effluents. The aim of the paper is to study the removal of the acid, reactive and direct textile dyes such as C.I. Acid Orange 7, C.I. Reactive Black 5 and C.I. Direct Blue 71 on the commercially available anion exchangers (Lewatit MonoPlus MP 62, Lewatit MonoPlus MP 64, Lewatit MonoPlus MP 500, Lewatit MonoPlus M 500, Amberlite IRA 67, Amberlite IRA 478RF, Amberlite IRA 458 and Amberlite IRA 958) differing not only in basicity of the functional groups but also in composition and structure of the matrix. Comparison of the sorption parameters obtained by the batch method taking into account influence of phase contact time, dyes initial concentration and solution pH were discussed in detail. Desorption conditions depending on the dyes sorption mechanism were also presented. Influence of the auxiliaries typically present in textile effluents such as inorganic electrolytes and different surfactants on the amounts of dyes retained by the anion exchangers was presented. The adsorption behaviour of the polyacrylic Amberlite IRA 958 demonstrates that it can be a promising adsorbent for the textile wastewater treatment. The results obtained with raw textile wastewaters purification confirmed this statement.",book:{id:"4599",slug:"ion-exchange-studies-and-applications",title:"Ion Exchange",fullTitle:"Ion Exchange - Studies and Applications"},signatures:"Monika Wawrzkiewicz and Zbigniew Hubicki",authors:[{id:"141883",title:"Prof.",name:"Zbigniew",middleName:null,surname:"Hubicki",slug:"zbigniew-hubicki",fullName:"Zbigniew Hubicki"},{id:"173310",title:"Dr.",name:"Monika",middleName:null,surname:"Wawrzkiewicz",slug:"monika-wawrzkiewicz",fullName:"Monika Wawrzkiewicz"}]},{id:"52110",doi:"10.5772/64935",title:"Electrodeposition from Deep Eutectic Solvents",slug:"electrodeposition-from-deep-eutectic-solvents",totalDownloads:3485,totalCrossrefCites:7,totalDimensionsCites:29,abstract:"Deep eutectic solvents constitute a class of compounds sharing many similarities with properly named ionic liquids. The accepted definition of ionic liquid is a fluid (liquid for T<100 °C) consisting of ions, while DES are eutectic mixtures of Lewis or Brønsted acids and bases. Their most attractive properties are the wide potential windows and the chemical properties largely different from aqueous solutions. In the last few decades, the possibility to electrodeposit decorative and functional coatings employing deep eutectic solvents as electrolytes has been widely investigated. A large number of the deposition procedures described in literature, however, cannot find application in the industrial practice due to competition with existing processes, cost or difficult scalability. From one side, there is the real potential to replace existing plating protocols and to find niche applications for high added-value productions; to the other one, this paves the path towards the electrodeposition of metals and alloys thermodynamically impossible to be obtained via usual aqueous solution processes. The main aim of this chapter is therefore the critical discussion of the applicability of deep eutectic solvents to the electrodeposition of metals and alloys, with a particular attention to the industrial and applicative point of view.",book:{id:"5381",slug:"progress-and-developments-in-ionic-liquids",title:"Ionic Liquids",fullTitle:"Progress and Developments in Ionic Liquids"},signatures:"R. Bernasconi, G. Panzeri, A. Accogli, F. Liberale, L. Nobili and L.\nMagagnin",authors:[{id:"188210",title:"Associate Prof.",name:"Luca",middleName:null,surname:"Magagnin",slug:"luca-magagnin",fullName:"Luca Magagnin"},{id:"194387",title:"MSc.",name:"Roberto",middleName:null,surname:"Bernasconi",slug:"roberto-bernasconi",fullName:"Roberto Bernasconi"},{id:"194388",title:"MSc.",name:"Gabriele",middleName:null,surname:"Panzeri",slug:"gabriele-panzeri",fullName:"Gabriele Panzeri"},{id:"194389",title:"MSc.",name:"Alessandra",middleName:null,surname:"Accogli",slug:"alessandra-accogli",fullName:"Alessandra Accogli"},{id:"194390",title:"MSc.",name:"Francesco",middleName:null,surname:"Liberale",slug:"francesco-liberale",fullName:"Francesco Liberale"},{id:"194391",title:"Prof.",name:"Luca",middleName:null,surname:"Nobili",slug:"luca-nobili",fullName:"Luca Nobili"}]},{id:"25422",doi:"10.5772/28293",title:"Electrochemical Polymerization of Aniline",slug:"electrochemical-polymerization-of-aniline",totalDownloads:11460,totalCrossrefCites:3,totalDimensionsCites:29,abstract:null,book:{id:"607",slug:"electropolymerization",title:"Electropolymerization",fullTitle:"Electropolymerization"},signatures:"Milica M. Gvozdenović, Branimir Z. Jugović, Jasmina S. Stevanović, Tomislav Lj. Trišović and Branimir N. Grgur",authors:[{id:"73400",title:"Dr.",name:"Milica",middleName:null,surname:"Gvozdenović",slug:"milica-gvozdenovic",fullName:"Milica Gvozdenović"},{id:"78801",title:"Dr.",name:"Branimir",middleName:null,surname:"Jugović",slug:"branimir-jugovic",fullName:"Branimir Jugović"},{id:"78807",title:"Dr.",name:"Jasmina",middleName:null,surname:"Stevanović",slug:"jasmina-stevanovic",fullName:"Jasmina Stevanović"},{id:"120374",title:"Dr.",name:"Tomislav",middleName:null,surname:"Trišović",slug:"tomislav-trisovic",fullName:"Tomislav Trišović"},{id:"120376",title:"Prof.",name:"Branimir",middleName:null,surname:"Grgur",slug:"branimir-grgur",fullName:"Branimir Grgur"}]}],mostDownloadedChaptersLast30Days:[{id:"52110",title:"Electrodeposition from Deep Eutectic Solvents",slug:"electrodeposition-from-deep-eutectic-solvents",totalDownloads:3487,totalCrossrefCites:7,totalDimensionsCites:29,abstract:"Deep eutectic solvents constitute a class of compounds sharing many similarities with properly named ionic liquids. The accepted definition of ionic liquid is a fluid (liquid for T<100 °C) consisting of ions, while DES are eutectic mixtures of Lewis or Brønsted acids and bases. Their most attractive properties are the wide potential windows and the chemical properties largely different from aqueous solutions. In the last few decades, the possibility to electrodeposit decorative and functional coatings employing deep eutectic solvents as electrolytes has been widely investigated. A large number of the deposition procedures described in literature, however, cannot find application in the industrial practice due to competition with existing processes, cost or difficult scalability. From one side, there is the real potential to replace existing plating protocols and to find niche applications for high added-value productions; to the other one, this paves the path towards the electrodeposition of metals and alloys thermodynamically impossible to be obtained via usual aqueous solution processes. The main aim of this chapter is therefore the critical discussion of the applicability of deep eutectic solvents to the electrodeposition of metals and alloys, with a particular attention to the industrial and applicative point of view.",book:{id:"5381",slug:"progress-and-developments-in-ionic-liquids",title:"Ionic Liquids",fullTitle:"Progress and Developments in Ionic Liquids"},signatures:"R. Bernasconi, G. Panzeri, A. Accogli, F. Liberale, L. Nobili and L.\nMagagnin",authors:[{id:"188210",title:"Associate Prof.",name:"Luca",middleName:null,surname:"Magagnin",slug:"luca-magagnin",fullName:"Luca Magagnin"},{id:"194387",title:"MSc.",name:"Roberto",middleName:null,surname:"Bernasconi",slug:"roberto-bernasconi",fullName:"Roberto Bernasconi"},{id:"194388",title:"MSc.",name:"Gabriele",middleName:null,surname:"Panzeri",slug:"gabriele-panzeri",fullName:"Gabriele Panzeri"},{id:"194389",title:"MSc.",name:"Alessandra",middleName:null,surname:"Accogli",slug:"alessandra-accogli",fullName:"Alessandra Accogli"},{id:"194390",title:"MSc.",name:"Francesco",middleName:null,surname:"Liberale",slug:"francesco-liberale",fullName:"Francesco Liberale"},{id:"194391",title:"Prof.",name:"Luca",middleName:null,surname:"Nobili",slug:"luca-nobili",fullName:"Luca Nobili"}]},{id:"74147",title:"Electrochemical Impedance Spectroscopy (EIS): A Review Study of Basic Aspects of the Corrosion Mechanism Applied to Steels",slug:"electrochemical-impedance-spectroscopy-eis-a-review-study-of-basic-aspects-of-the-corrosion-mechanis",totalDownloads:2662,totalCrossrefCites:11,totalDimensionsCites:21,abstract:"AC impedance measurements have been applied for over twenty years in electrochemistry and physics to investigate the electrical properties of conductive materials and their interfaces using an external electrical impulse (VOLTAGE, V or CURRENT, I) as driving force. Furthermore, its application has recently appeared to be destined in the Biotechnology field as an effective tool for rapid microbiologic diagnosis of living organism in situ. However, there is no doubt that the electrochemical impedance spectroscopy (EIS) is still one of the most useful techniques around the world for metal corrosion control and its monitoring. Corrosion has long been recognized as one of the most expensive stumbling blocks that concern many industries and government agencies, because it is a steel destructive phenomenon that occurs due to the chemical interaction with aqueous environments and takes place at the interface between metal and electrolyte producing an electrical charge transfer or ion diffusion process. Consequently, it is experimentally possible to determine through the EIS technique the mechanism and control that kinectics of corrosion reactions encounter. First, EIS data is collected through a potentiostat/galvanostat apparatus. After, it is fitted to a mathematical model (i.e. an equivalent electrical circuit, EEC) for its interpretation and analysis, fundamentally seeking a meaningful physical interpretation. Finally, this review reports some basic aspects of the corrosion mechanism applied to steels through the experimental EIS response using Nyquist or Bode plots. Examples are given for different applied electrochemical impedance cases in which steel is under study intentionally exposed to a corrosive aqueous solution by applying a sinusoidal potential at various test conditions.",book:{id:"10054",slug:"electrochemical-impedance-spectroscopy",title:"Electrochemical Impedance Spectroscopy",fullTitle:"Electrochemical Impedance Spectroscopy"},signatures:"Héctor Herrera Hernández, Adriana M. Ruiz Reynoso, Juan C. Trinidad González, Carlos O. González Morán, José G. Miranda Hernández, Araceli Mandujano Ruiz, Jorge Morales Hernández and Ricardo Orozco Cruz",authors:[{id:"114381",title:"Dr.",name:"Jorge",middleName:null,surname:"Morales-Hernandez",slug:"jorge-morales-hernandez",fullName:"Jorge Morales-Hernandez"},{id:"215540",title:"Dr.",name:"Araceli",middleName:null,surname:"Mandujano Ruiz",slug:"araceli-mandujano-ruiz",fullName:"Araceli Mandujano Ruiz"},{id:"268773",title:"Dr.",name:"Hector",middleName:null,surname:"Herrera Hernandez",slug:"hector-herrera-hernandez",fullName:"Hector Herrera Hernandez"},{id:"268774",title:"Dr.",name:"Carlos O.",middleName:null,surname:"Gonzalez Moran",slug:"carlos-o.-gonzalez-moran",fullName:"Carlos O. Gonzalez Moran"},{id:"314695",title:"Dr.",name:"Adriana Mercedes",middleName:null,surname:"Ruiz Reynoso",slug:"adriana-mercedes-ruiz-reynoso",fullName:"Adriana Mercedes Ruiz Reynoso"}]},{id:"62242",title:"Oxygen Reduction Reaction",slug:"oxygen-reduction-reaction",totalDownloads:4028,totalCrossrefCites:8,totalDimensionsCites:18,abstract:"In this chapter, the oxygen reduction reaction (ORR), which is one of the most important reactions in energy conversion systems such as fuel cells, including its reaction kinetics, is presented. Recent developments in electrocatalysts for ORR in fuel cells, including low and non-Pt electrocatalysts, metal oxides, transition metal macrocycles and chalgogenides, are discussed. Understanding of the interdependence of size, shape and activity of the electrocatalysts is evaluated. The recent development of ORR electrocatalysts with novel nanostructures is also reported. The mechanism catalysed by these electrocatalysts is presented. Finally, the perspectives of future trends for ORR are discussed.",book:{id:"6778",slug:"electrocatalysts-for-fuel-cells-and-hydrogen-evolution-theory-to-design",title:"Electrocatalysts for Fuel Cells and Hydrogen Evolution",fullTitle:"Electrocatalysts for Fuel Cells and Hydrogen Evolution - Theory to Design"},signatures:"Lindiwe Khotseng",authors:[{id:"236596",title:"Dr.",name:"Lindiwe Eudora",middleName:null,surname:"Khotseng",slug:"lindiwe-eudora-khotseng",fullName:"Lindiwe Eudora Khotseng"}]},{id:"40709",title:"The Role of Ion Exchange Chromatography in Purification and Characterization of Molecules",slug:"the-role-of-ion-exchange-chromatography-in-purification-and-characterization-of-molecules",totalDownloads:12954,totalCrossrefCites:2,totalDimensionsCites:9,abstract:null,book:{id:"2549",slug:"ion-exchange-technologies",title:"Ion Exchange Technologies",fullTitle:"Ion Exchange Technologies"},signatures:"Hidayat Ullah Khan",authors:[{id:"140538",title:"Dr.",name:"Hidayat",middleName:null,surname:"Khan",slug:"hidayat-khan",fullName:"Hidayat Khan"}]},{id:"49055",title:"Ion Exchange Method for Removal and Separation of Noble Metal Ions",slug:"ion-exchange-method-for-removal-and-separation-of-noble-metal-ions",totalDownloads:3029,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"Ion exchange has been widely applied in technology of chemical separation of noble metal ions. This is associated with dissemination of methods using various ion exchange resins which are indispensable in many fields of chemical industry. Due to small amounts of noble elements in nature and constant impoverishment of their natural raw materials, of particular importance are physicochemical methods of their recovery from the second sources e.g. worn out converters of exhausted gases, chemical catalysts, dental alloys, anodic sludges from cooper and nickiel electrorefining as well as waste waters and running off waters from refineries containing trace amount of noble metals. It should be stated that these waste materials are usually pyro- and hydrometallurgically processed. Recovery of noble metals, from such raw materials requires individual approach to each material and application of selective methods for their removal. Moreover, separation of noble metals, particularly platinum metals and gold from geological samples, industrial products, synthetic mixtures along with other elements is a problem of significant importance nowadays. In the paper the research on the applicability of different types of ion exchangers for the separation of noble metals will be presented. The effect of the different parameters on their separation will be also discussed. The examples of the removal of noble metals chlorocomplexes will also be presented in detail.",book:{id:"4599",slug:"ion-exchange-studies-and-applications",title:"Ion Exchange",fullTitle:"Ion Exchange - Studies and Applications"},signatures:"Zbigniew Hubicki, Monika Wawrzkiewicz, Grzegorz Wójcik, Dorota\nKołodyńska and Anna Wołowicz",authors:[{id:"141883",title:"Prof.",name:"Zbigniew",middleName:null,surname:"Hubicki",slug:"zbigniew-hubicki",fullName:"Zbigniew Hubicki"},{id:"173610",title:"Dr.",name:"Dorota",middleName:null,surname:"Kołodyńska",slug:"dorota-kolodynska",fullName:"Dorota Kołodyńska"}]}],onlineFirstChaptersFilter:{topicId:"505",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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