Number of retrieved synonyms and hypernyms words.
\r\n\t
",isbn:"978-1-83881-111-2",printIsbn:"978-1-83880-992-8",pdfIsbn:"978-1-83881-112-9",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"acb2875b3bfc189c9881a9b44b6a5184",bookSignature:"Dr. Abdo Abou Jaoudé",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11865.jpg",keywords:"Linear Operators, Normal Operators, Spectral Theorem, Applications, Differential Operators, Integral Operators, Functional Calculus, Complex Variables, Complex Analysis, Theory, Recent Advances, Latest Trends",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 13th 2022",dateEndSecondStepPublish:"June 21st 2022",dateEndThirdStepPublish:"August 20th 2022",dateEndFourthStepPublish:"November 8th 2022",dateEndFifthStepPublish:"January 7th 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"7 days",secondStepPassed:!0,areRegistrationsClosed:!1,currentStepOfPublishingProcess:3,editedByType:null,kuFlag:!1,biosketch:"Abdo Abou Jaoudé is a pioneering Associate Professor of Mathematics and Statistics at Notre Dame University-Louaizé. 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They are largely used in the next generation of the Semantic Web that focuses on supporting a better cooperation between humans and machines [2]. Since manual ontology construction is costly, time-consuming, error-prone, and inflexible to change, it is hoped that an automated ontology learning process will result in more effective and more efficient ontology construction and also be able to create ontologies that better match a specific application [20]. Ontology learning has recently become a major focus for research whose goal is to facilitate the construction of ontologies by decreasing the amount of effort required to produce an ontology for a new domain. However, most current approaches deal with narrowly-defined specific tasks or a single part of the ontology learning process rather than providing complete support to users. There are few studies that attempt to automate the entire ontology learning process from the collection of domain-specific literature and filtering out documents irrelevant to the domain, to text mining to build new ontologies or enrich existing ones.
\n\t\t\tThe World Wide Web is a rich source of documents that is useful for ontology learning. However, because there is so much information of varying quality covering a huge range of topics, it is important to develop document discovery mechanisms based on intelligent techniques such as focused crawling [7] to make the collection process easier for a new domain. However, due to the huge number of retrieved documents, we still require an automatic mechanism rather than domain experts in order to separate out the documents that are truly relevant to the domain of interest. Text classification techniques can be used to perform this task.
\n\t\t\tIn order to enrich an ontology’s vocabulary, several ontology learning approaches attempt to extract relevant information from WordNet, a semantic network database for the English language developed by Princeton University [23]. WordNet provides a rich knowledge base in which concepts, called synonymy sets or synsets, are linked by semantic relations. However, a main barrier to exploiting the word relationships in WordNet is that most words have multiple senses. Due to this ambiguity, not all senses for a given word can be used as a source of vocabulary. Expanding a concept’s vocabulary based on an incorrect word sense would add many unrelated words to that concept and degrade the quality of the overall ontology. Thus, candidate word senses must be filtered very carefully. Most existing approaches have had mixed results with sense disambiguation, so the vocabulary for a specific domain mined from WordNet typically requires further manual filtering to be useful.
\n\t\t\tIn our work, we employ a general ontology learning framework extracts new relevant vocabulary words from two main sources, i.e., Web documents and WordNet. This framework can be used for ontologies in any domain. We demonstrate our approach to a biological domain, specifically the domain of amphibian anatomy and morphology. In this work, we are exploring two techniques for expanding the vocabulary in an ontology: 1) lexical expansion using WordNet; and 2) lexical expansion using text mining. The lexical expansion from WordNet approach accurately extracts new vocabulary for an ontology for any domain covered by WordNet. We start with a manually-created ontology on amphibian morphology. The words associated with each concept in the ontology, the concept-words, are mapped onto WordNet and we employ a similarity computation method to identify the most relevant sense from multiple senses returned by WordNetfor a given concept-word. We then enrich the vocabulary for that original concept in the amphibian ontology by including the correct sense’s associated synonyms and hypernyms.
\n\t\t\tOur text mining approach uses a focused crawler to retrieve documents related to the ontology’s domain, i.e., amphibian, anatomy and morphology, from a combination of general search engines, scholarly search engines, and online digital libraries. We use text classification to identify, from the set of all collected documents, those most likely to be relevant to the ontology’s domain. Because it has been shown to be highly accurate, we use a SVM (Support Vector Machine) classifier for this task [6] [40]. Finally, we implemented and evaluatedseveral text mining techniques to extract relevant information for the ontology enrichment from the surviving documents.
\n\t\t\tIn this paper, we describe our work on the ontology learning process and present experimental results for each of the two approaches. In section 2, we present a brief survey of current research on ontology learning, focused crawlers, document classification, information extraction, and the use of WordNet for learning new vocabulary and disambiguating word senses. In section 3, we present our ontology learning framework and our two approaches, i.e., lexical expansion using WordNet and text mining. Sections 4 and 5 describe these approaches in more detail and report the results of our evaluation experiments. The final section presents conclusions and discusses our ongoing and future work in this area.
\n\t\tAn ontology is an explicit, formal specification of a shared conceptualization of a domain of interest [11], where formal implies that the ontology should be machine-readable and the domain can be any that is shared by a group or community. Much of current research into ontologies focuses on issues related to ontology construction and updating. In our view, there are two main approaches to ontology building: (i) manual construction of an ontology from scratch, and (ii) semi-automatic construction using tools or software with human intervention. It is hoped that semi-automatic generation of ontologies will substantially decrease the amount of human effort required in the process [12][18][24]. Because of the difficulty of the task, entirely automated approaches to ontology construction are currently not feasible.
\n\t\t\tOntology learning has recently been studied to facilitate the semi-automatic construction of ontologies by ontology engineers or domain experts. Ontology learning uses methods from a diverse spectrum of fields such as machine learning, knowledge acquisition, natural language processing, information retrieval, artificial intelligence, reasoning, and database management [29]. Gómez-Pérez et al [10] present a thorough summary of several ontology learning projects that are concerned with knowledge acquisition from a variety of sources such as text documents, dictionaries, knowledge bases, relational schemas, semi-structured data, etc. Omelayenko [24] discusses the applicability of machine learning algorithms to learning of ontologies from Web documents and also surveys the current ontology learning and other closely related approaches. Similar to our approach, authors in [20] introduces an ontology learning framework for the Semantic Web thatincluded ontology importation, extraction, pruning, refinement, and evaluation giving the ontology engineers a wealth of coordinated tools for ontology modeling. In addition to a general framework and architecture, they have implemented Text-To-Onto system supporting ontology learning from free text, from dictionaries, or from legacy ontologies. However, they do not mention any automated support to collect the domain documents from the Web or how to automatically identify domain-relevant documents needed by the ontology learning process. Maedche et al. have presented in another paper [21] a comprehensive approach for bootstrapping an ontology-based information extraction system with the help of machine learning. They also presented an ontology learning framework which is one important step in their overall bootstrapping approach but it has still been described as a theoretic model and did not deal with the specific techniques used in their learning framework. Agirre et al., [1] have presented an automatic method to enrich very large ontologies, e.g., WordNet, that uses documents retrieved from the Web. However, in their approach, the query strategy is not entirely satisfactory in retrieving relevant documents which affects the quality and performance of the topic signatures and clusters. Moreover, they do not apply any filtering techniques to verify that the retrieved documents are truly on-topic. Inspiring the idea of using WordNet to enrich vocabulary for ontology domain, we have presented the lexical expansion from WordNet approach [18] providing a method of accurately extract new vocabulary for an ontology for any domain covered by WordNet.
\n\t\t\tMany ontology learning approaches require a large collection of input documents in order to enrich the existing ontology [20]. Although most employ text documents [4], only a few deal with ontology enrichment from documents collected from the Web rather than a manually created, domain-relevant corpus. To create a corpus from the Web, one can use general purpose crawlers and search engines, but this approach faces problems with scalability due to the rapid growth of the Web. Focused crawlers, on the other hand, overcome this drawback, i.e., they yield good recall as well as good precision, by restricting themselves to a limited domain [7]. Ester et al [7] introduce a generic framework for focused crawling consisting of two major components: (i) specification of the user interest and measuring the resulting relevance of a given Web page; and (ii) a crawling strategy.
\n\t\t\tRather than working with domain-relevant documents from which vocabulary can be extracted, some ontology construction techniques exploit specific online vocabulary resources. WordNet is an online semantic dictionary, partitioning the lexicon into nouns, verbs, adjectives, and adverbs [23]. Some current researchers extract words from WordNet’s lexical database to enrich ontology vocabularies [8][16][31]. In [27], Reiter et al describe an approach that combines the Foundational Model of Anatomy with WordNet by using an algorithm for domain-specific word sense disambiguation. In another approach similar to ours, Speretta et al exploit semantics by applying existing WordNet-based algorithms [31]. They calculate the relatedness between the two words by applying a similarity algorithm, and evaluated the effect of adding a variable number of the highest-ranked candidate words to each concept. A Perl package called Word-Net::Similarity [25] is a widely-used tool for measuring semantic similarity that contains implementations of eight algorithms for measuring semantic similarity. In our work, we evaluate the WordNet-based similarity algorithms by using the JSWL package developed by [26] that implements some of the most commons similarity and relatedness measures between words by exploiting the hyponymy relations among synsets.
\n\t\t\tSemantic similarity word sense disambiguation approaches in WordNet can be divided into two broad categories based on (i) path length and (ii) information content. Warinet al [37] describe a method of disambiguating an ontology and WordNet using five different measures. These approaches disambiguate semantic similarity based on the information content, (e.g., Lin [16], Jiang-Conrath [13], and Resnik [28]) and path length method (e.g., Leacock-Chodorow [15], and Wu-Palmer [38]). They present a new method that disambiguatesthe words in their ontology, the Common Procurement Vocabulary. Semantic similarity can also be calculated using edge-counting techniques. Yang and Powers [39] present a new path-weighting model to measure semantic similarity in WordNet. They compare their model to a benchmark set by human similarity judgments and found that their geometric model simulates human judgments well. Varelas et al [35] propose the Semantic Similarity Retrieval Model (SSRM), a general document similarity and information retrieval method suitable for retrieval in conventional document collections and the Web. This approach is based on the term-based Vector Space Model by computing TF-IDF weights to term representations of documents. These representations are then augmented by semantically similar terms (which are discovered from WordNet by applying a semantic query in the neighborhood of each term) and by re-computing weights to all new and pre-existing terms.
\n\t\t\tText mining, also known as text data mining or knowledge discovery from textual databases, refers generally to the process of extracting interesting and non-trivial patterns or knowledge from unstructured text documents [3][12]. Tan [33] presents a good survey of text mining products/applications and aligns them based on the
In order to improve accuracy of the learned ontologies, the documents retrieved by focused crawlers may need to be automatically filtered by using some text classification technique such as Support Vector Machines (SVM), k-Nearest Neighbors (kNN), Linear Least-Squares Fit, TF-IDF, etc. A thorough survey and comparison of such methods and their complexity is presented in [40] and the authors in [6] conclude that SVM to be most accurate for text classification and it is also quick to train. SVM [34] is a machine learning model that finds an optimal hyper plane to separate two then classifies data into one of two classes based on the side on which they are located [5] [14].The k-nearest neighbors (kNN) algorithm is among the simplest of all machine learning algorithms: an object is classified by a majority vote of its neighbors, with the object being assigned to the class most common amongst its k nearest neighbors. In pattern recognition, the kNN is a method for classifying objects based on closest training examples in the feature space. It is a type of instance-based learning where the function is only approximated locally and all computation is deferred until classification. This algorithm has also been used successfully in many text categorization applications [41].
\n\t\tIn this section, we present the architecture of our ontology learning process framework (c.f. Figure 1) that incorporates two approaches, i.e., lexical expansion and text mining, to identify new domain-relevant vocabulary for ontology enrichment. These approaches are presented in detail in sections 4 and 5.
\n\t\t\t\tThis approach starts from a small manually constructed ontology, then tries to mine relevant words from WordNet in order to enrich the vocabulary associated with ontology concepts. It contains main following steps:
\n\t\t\t\t\tExtract all single concept-words from the seed ontology. Filter these words by removing stop-words; locate each remaining word’s senses within WordNet.
Build a reference hypernym tree for each word sense as a reference source for semantic similarity disambiguation.
If a concept-word has multiple senses, identify the correct word sense usinga similarity computation algorithm on reference hypernym tree.
Select the most similar sense and add its synonyms and hypernyms to the corresponding concept in the ontology.
Architecture of ontology learning framework.
The main processes are as following:
\n\t\t\t\t\tWe begin with an existing small, manually-created amphibian morphology ontology [22]. From this, we automatically generate queries for each concept in the hierarchically-structured ontology.
We submit these queries to a variety of Web search engines and digital libraries. The program downloads the potentially relevant documents listed on the first page (top-ranked 10) results.
Next, we apply SVM classification to filter out documents in the search results that match the query well but are less relevant to the domain of our ontology. For example, a document contains the word “cell” but it is in the context of cellphone, telecommunication… will be filtered out. Other documents containing that word “cell” with the context of amphibian, embryo structure or biological… will be kept.
After the above process, we have created a collection of documents relevant to amphibian morphology. These are input to an information extraction (IE) system to mine information from documents that can be used to enrich the ontology.
\n\t\t\t\t\t\n\t\t\t\tThe need for terminological standardization of anatomy is pressing in amphibian morphological research [22]. A long-term NSF-sponsored project, AmphibAnat, aims to integrate the amphibian anatomical ontology knowledge base with systematic, biodiversity, embryological and genomic resources. However, another important goal of this project is to semi-automatically construct and enrich the amphibian anatomical ontology. An amphibian ontology will facilitate the integration of anatomical data representing all orders of amphibians, thus enhancing knowledge representation of amphibian biology and diversity.
\n\t\t\t\tA part of the amphibian ontology
Based on information in a manually constructed seed ontology, we use a focused crawler and data-mining software in order to mine electronic resources for instances of concepts and properties to be added to the existing ontologies [17][19]. We also use concept-words of this ontology to match the corresponding relevant words and senses in WordNet. The current amphibian ontology created by this project consists of 1986 semantic concepts (with the highest depth level is 9) and 570 properties. Figure 2 presents a part of this ontology which is available in two main formats: (i) OWL and (ii) OBO - Open Biomedical Ontology.
\n\t\t\t\t\n\t\t\tIn this section, we introduce our two main vocabulary-extraction approaches, one based on identifying information from an already-existing vocabulary resource (WordNet) and one based on extracting vocabulary directly from the domain literature.The advantages of using WordNet is that it contains words and relationships that are, because it was manually constructed, highly accurate.However, the drawbacks are that the vocabulary it contains is broad and thus ambiguous.Also, for specialized domains, appropriate words and/or word senses are likely to be missing. Thus, we contrast this approach with one that works directlyon the domain literature.In this case, the appropriate words and word senses are present and ambiguity is less of a factor. However, the relationships between the word senses are implicit in how they are used in the text rather than explicitly represented.
\n\t\t\tThis approach attempts to identify the correct WordNet sense for each concept-word and then add that sense’s synsets and hypernyms as new vocabulary for the associated concept. We base our concept-word sense disambiguation on comparing the various candidate senses to those in a reference source of senses for the domain of the ontology. To provide this standard reference, we manually disambiguate the WordNet senses for the concept-words in the top two levels of the amphibian ontology. We then create a reference hypernym tree that contains the WordNethypernyms of these disambiguated WordNet senses. The problem of solving the lexical ambiguity that occurs whenever a given concept-word has several different meanings is now simplified to comparing the hypernym tree for each candidate word sense with the reference hypernym tree. We then compute a tree similarity metric between each candidate hypernym tree and the reference hypernym tree to identify the most similar hypernym tree and, by association, the word sense most closely related to the ontology domain.
\n\t\t\t\tWordNet has become a broad coverage thesaurus that is now widely used in natural language processing and information retrieval [32]. Words in WordNet are organized into synonym sets, called
For a given word, we can build a hypernym tree including all hypernyms in their hierarchy returned by WordNet. When a word has multiple senses, we get a set of hypernym trees, one per sense. In order to find the hypernyms of a given word in WordNet, we must provide the word and the syntactic class in which we are interested. In our approach, since ontologies generally represent information about objects, we are restricting the word senses considered to only the noun senses for a candidate word.
\n\t\t\t\tBecause WordNet organizes nouns into IS-A hypernym hierarchies that provide taxonomic information, it is useful for identifying semantic similarity between words [25]. Our approach constructs a reference hypernym tree (or standard hypernym tree) from a few manually disambiguated words. When a word has multiple senses, we construct the hypernym tree for each sense. Then, we calculate how close each candidate sense’s hypernym tree is to this reference source. We argue that the more similar a hypernym tree is to the reference tree, the closer the word sense is to the key concepts in the ontology.
\n\t\t\t\t\tA part of the reference hypernym tree.
To build the reference hypernym tree, we consider only the top two levels of concepts of the amphibian ontology since they cover many vocabularies appearing at lower levels. In addition, since the concepts are also related using the “IS A” relation, the hypernyms of the concepts in top two levels of the ontology are also hypernyms of the concepts in the lower levels. The main steps of this process are as following: first, we convert each concept in top two level into concept-words that can be submitted to WordNet, for instance the concept “anatomical_structure” is divided into two concept-words “anatomical” and “structure”. The top two levels of our ontology contain 15 concepts and 19 concept-words. Then, we use WordNet to collect all the hypernyms for each concept-word. We manually choose the hypernym that best matches the meaning in our domain and then add to the reference hypernym tree. Figure 3 presents a part of our reference hypernym tree that contains 110 hypernyms covering 12 hierarchical levels. This reference tree will be used as truth to evaluate the correct sense extracted from WordNet for each experiment word.
\n\t\t\t\t\t\n\t\t\t\tIn this section, we present our tree-based similarity measurement technique that is used to compare hypernym trees corresponding to different senses of a concept-word with the reference hypernym tree. Our similarity measure is based on two factors:
\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
Once the hypernym tree is constructed for each sense, we are able to apply the similarity computation algorithm to calculate these two above factors (i.e. D and CE) for each case. Then, we weight these two factors to get the highest value.
\n\t\t\t\t\t\n\t\t\t\t\t\tFigure 4 shows an example of how the reference hypernym tree can be used to disambiguate word senses and select the most relevant one. Suppose that the hypernym trees in this example, i.e., HTree1, HTree2 and HTree3, each correspond to one sense of a given concept-word. We compare each hypernym tree to the reference hypernym tree by calculating the matched tree depth and the number of common elements between two trees. Results show that the first tree HTree1 is closest to the standard tree with the depth (D=6) and number of common elements (CE=13) are greater than others.
\n\t\t\t\t\tSimilarity computation using the Reference (Standard) HypernymTree.
\n\t\t\t\t\t\t
As discussed in Section 3.2, we use the amphibian morphology ontology developed by the AmphibAnat project [22] for our experiments. We used WordNet (3.0) as the lexical source and the API library of MIT Java WordNet Interface (JWI 2.1.5) to locate the synsets and hypernyms for a given concept-word.
\n\t\t\t\t\tWe begin by processing names for the concepts in the top two levels of the amphibian ontology and manually disambiguating them to create the reference hypernym tree. We then process the names for the 1971 concepts in levels 3 and below. Since many concepts are named with phrases of two or more wordsm and WordNet only contains single words, we need to convert these words into single words, i.e., the concept-words. After removing duplicate concept-words, e.g., concepts “anatomical_structure” and “multi-tissue_structure” have a duplicate concept-word, “structure”, stopwords (e.g., of, to, for) and numbers, we end up with a set of 877 unique concept-words. However, because the ontology is very domain specific, many of these concept-words do not appear in WordNet at all. Very specific terms in the amphibian domain, e.g., premaxilla, dorsalis, adjectives, e.g., nervous, embryonic, hermaphroditic, and incomplete words added during the ontology creation process, e.g., sp, aa, do not appear in WordNet. Therefore, we report results using only the 308 concept-words that were contained in WordNet.
\n\t\t\t\t\tWe matched these 308 words to WordNet to identify all their corresponding senses, synonyms and hypernyms. However, not all of the senses for a given word are relevant so we need to disambiguate the semantic similarity of these senses to choose the closest and most correct one for our amphibian domain. We applied each of three similarity computation algorithms, to determine the closest sense for each word and evaluated them: 1) based on the number of matched tree depth (#Depth); 2) based on the number of common elements ( #CE); and 3) based on the sum of both factors (#Depth+CE). For each method, we got a list of word senses selected by the algorithm and compared these senses to the truth-list provided by our human expert to evaluate the effectiveness of our algorithm.
\n\t\t\t\t\t\n\t\t\t\t\t\t
In order to evaluate the results of our both approaches, i.e., Lexical Expansion and Text Mining, we needed to know the correct word sense (if any) for each word. An expert in the amphibian domain helped us by independently judging the words and senses identified by each technique and identifying which were correct. These judgments formed the truth lists against which the words extracted by text mining and the senses chosen by the lexical expansion were compared.
\n\t\t\t\t\tInformation extraction effectiveness is measured in terms of the classic Information Retrieval metrics of Precision, Recall and F-measure. We used these measures for both approaches, but with some different definitions of measure for each approach. In the lexical expansion approach, since each word in WordNet may have different senses and we have to find the correct one, we define:
\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t
•
We use F-measure which is calculated as following for both approaches.
\n\t\t\t\t\tBecause we want to enhance the ontology with only truly relevant words, we want a metric that is biased towards high precision versus high recall. We chose to use the F-measure with a β value that weights precision four times higher than recall.
\n\t\t\t\tAmong 308 word returned from WordNet, human expert judged that 252 of the extracted words were correct. Of the 56 incorrect words returned, there were no senses in WordNet relevant to the amphibian domain. Since each of above 252 returned words may have some correct senses judged by the human expert, we got finally 285 correct senses.In order to see how well each algorithm performed, we implemented different thresholds to see how results are varied as we increased our selectivity based on level of match and/or number of common elements matched. We varied the depth from 1 to 10, the common elements from 2 to 20, and the sum of the two from 3 to 30. For example with the #Depth+CE method, the range of threshold t is from 3 to 30; the value t=15 means that we take only senses having the number #Depth+CE is greater than 15. Figures 5, 6 and 7 show the F-measures achieved by three methods of #Depth, #CE and #Depth+CE respectively using various threshold values.
\n\t\t\t\t\tF-measure of the #Depth only method (β=0.25).
F-measure of the #CE only method (β=0.25).
F-measure of the #Depth+CE method (β=0.25).
We found that we got poor results when using depth only, i.e., a maximum F-measure of 0.42 with a threshold of 1, but the common elements approach performed better with a maximum F-measure of 0.67 with a threshold of 10. However, the best result was achieved when we used the sum of depth and common element using a threshold t=15. This produced a precision of 74% and recall of 50% and an F-measure of 0.72. In this case, 155 words were found by the algorithm of which 115 were correct. Table 1 presents the number of unique synonym and hypernym words we could add to the ontology from WordNet based on our disambiguated senses.
\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t
#words returned | \n\t\t\t\t\t\t\t\t308 | \n\t\t\t\t\t\t\t\t291 | \n\t\t\t\t\t\t\t\t271 | \n\t\t\t\t\t\t\t\t225 | \n\t\t\t\t\t\t\t\t155 | \n\t\t\t\t\t\t\t\t98 | \n\t\t\t\t\t\t\t\t62 | \n\t\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t\t8 | \n\t\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t
# words correct | \n\t\t\t\t\t\t\t\t190 | \n\t\t\t\t\t\t\t\t178 | \n\t\t\t\t\t\t\t\t176 | \n\t\t\t\t\t\t\t\t149 | \n\t\t\t\t\t\t\t\t115 | \n\t\t\t\t\t\t\t\t70 | \n\t\t\t\t\t\t\t\t38 | \n\t\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t
#SYN | \n\t\t\t\t\t\t\t\t417 | \n\t\t\t\t\t\t\t\t352 | \n\t\t\t\t\t\t\t\t346 | \n\t\t\t\t\t\t\t\t308 | \n\t\t\t\t\t\t\t\t231 | \n\t\t\t\t\t\t\t\t140 | \n\t\t\t\t\t\t\t\t78 | \n\t\t\t\t\t\t\t\t26 | \n\t\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t
#HYN | \n\t\t\t\t\t\t\t\t164 | \n\t\t\t\t\t\t\t\t156 | \n\t\t\t\t\t\t\t\t151 | \n\t\t\t\t\t\t\t\t123 | \n\t\t\t\t\t\t\t\t80 | \n\t\t\t\t\t\t\t\t48 | \n\t\t\t\t\t\t\t\t42 | \n\t\t\t\t\t\t\t\t12 | \n\t\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t
Number of retrieved synonyms and hypernyms words.
To better understand this approach, we present an example based on the concept-word “cavity.” WordNet contains 4 different senses for this word: 1) pit, cavity, 2) cavity, enclosed space; 3) cavity, caries, dental caries, tooth decay; and 4) cavity, bodily cavity, cavum. Based on the total value of #Depth+CE, our algorithm correctly selects the fourth sense as the most relevant for the amphibian ontology (c.f., Table 2). Based on this sense, we then consider the synonyms
\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t
1st sense | \n\t\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t\t7 | \n\t\t\t\t\t\t\t\t12 | \n\t\t\t\t\t\t\t
2nd sense | \n\t\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t\t7 | \n\t\t\t\t\t\t\t\t11 | \n\t\t\t\t\t\t\t
3rd sense | \n\t\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t\t7 | \n\t\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t
Example of semantic similarity computation for the concept-word “cavity”.
In order to collect a corpus of documents from which ontological enrichments can be mined, we use the seed ontology as input to our focused search. For each concept in a selected subset of ontology, we generate a query that is then submitted to two main sources, i.e., search engines and digital libraries. To aid in query generation strategies, we created an interactive system that enables us to create queries from existing concepts in the ontology and allows us to change parameters such as the Website address, the number of returned results, the format of returned documents, etc.
\n\t\t\t\t\tWe next automatically submit the ontology-generated queries to multiple search engines and digital libraries related to the domain (e.g., Google, Yahoo, Google Scholar, http://www.amphibanat.org). For each query, we process the top 10 results from each search site using an HTML parser to extract the hyperlinks for collecting documents.
\n\t\t\t\tAlthough documents are retrieved selectively through restricted queries and by focused search, the results can contain some documents that are less relevant or not relevant at all. Therefore, we still need a mechanism to evaluate and verify the relevance of these documents to the predefined domain of the ontology. To remove unexpected documents, first we automatically remove those that are blank or too short, are duplicated documents, or those that are in a format that is not suitable for text processing. We then use LIBSVMclassification tool [5] to separate the remaining documents into two main categories: (i) relevant and (ii) non-relevant to the domain of ontology. We have also varied different parameters of LIBSVM such as kernel type (-t), degree (-d), weight (-wi)… in order to select the best parameters for our classification. Only those documents that are deemed truly relevant are input to the pattern extraction process.
\n\t\t\t\t\tThe SVM classification algorithm must first be trained, based on labeled examples, so that it can accurately predict unknown data (i.e., testing data). The training phase consists of finding a hyper plane that separates the elements belonging to two different classes. Our topic focused search combining with the SVM classification as described in [17] is 77.5% accurate, in order to evaluate our text mining approach in the absence of noise, we report in this paper our results based on the labeled relevant training examples. In future, the topic focused crawler will be used to feed directly into the text mining process.
\n\t\t\t\tAfter the topic-specific searching produces a set of documents related to the amphibian morphology domain, this phase information mines important vocabulary from the text of the documents. Specifically, our goal is to extract a set of words that are most related to the domain ontology concept-words. We have implemented and evaluated a vector space approach using two methods to calculate the Open Directory Project http://www.dmoz.org/
\n\t\t\t\t\t\t
This method,
where
\n\t\t\t\t\t\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
A word list sorted by weights is generated for each document from which the top k words are selected. These word lists are then merged in sorted order these words to only one list ranked by their weight. We performed some preliminary experiments, not reported here, which varied k from 1 to 110. The results reported here use k = 30, a value that was found to perform best.
\n\t\t\t\t\tb. Corpus-based selection (L2)
\n\t\t\t\t\tThis method,
where
\n\t\t\t\t\tW(i) is the weight of term i in the corpus
\n\t\t\t\t\tThe other factors are calculated as in L1 method.
\n\t\t\t\t\tc. Part-of-speech restriction (L1N, L2N)
\n\t\t\t\t\tFor each of the previous approaches, we implemented a version that removed all non-nouns from the final word list. We call the word lists,
a. Dataset and Experiments
\n\t\t\t\t\tThe current amphibian ontology is large and our goal is to develop techniques that can minimize manual effort by growing the ontology from a small, seed ontology. Thus, rather than using the whole ontology as input to the system, for our experiments we used a subset of only the five top-level concepts from the ontology whose meaning broadly covered the amphibian domain. Ultimately, we hope to compare the larger ontology we build to the full ontology built by domain expert.
\n\t\t\t\t\tWe found that when we expand the query containing the concept name with keywords describing the ontology domain overall, we get a larger number of relevant results. Based on these explorations, we created an automated module that, given a concept in the ontology, currently generates 3 queries with the expansion added, e.g., “amphibian” “morphology” “pdf”. From each of the five concepts, we generate three queries, for a total of 15 automatically generated queries. Each query is then submitted to each of the four search sites from which the top ten results are requested. This results in a maximum of 600 documents to process. However, because some search sites return fewer than ten results for some queries, we perform syntactic filtering, and duplicate documents are returned by search engines, in practice this number was somewhat smaller.
\n\t\t\t\t\tIt is crucial to have a filtering stage to remove irrelevant and slightly relevant documents to the amphibian ontology. We have adopted an SVM-based classification technique trained on 60 relevant and 60 irrelevant documents collected from the Web. In earlier experiments, our focused search combining with the SVM classification was able to collect new documents and correctly identify those related to the domain with an average accuracy 77.5% [17][19].
\n\t\t\t\t\tUltimately, the papers collected and filtered by the topic-specific spider will be automatically fed into the text mining software (with an optional human review in between). However, to evaluate the effectiveness of the text mining independently, without noise introduced by some potentially irrelevant documents, we ran our experiments using 60 documents manually judged as relevant, separated into two groups of 30, i.e.,
For the document-based approach, we took the top 30 words from each document and merged them. This created a list of 623 unique words (
When we selected only the nouns from L1 and L2, this resulted in lists L1N and L2N that contained 277 and 300 words, respectively. When these were merged and duplicates were removed, 375 words were submitted for judgment of which 253 were judged relevant and 122 were judged irrelevant to the amphibian morphology domain
\n\t\t\t\t\t\n\t\t\t\t\t\t
In the text mining approach, we define:
\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
Based on these two measures, we also calculate the F-measure as the equation (3) to evaluate methods’ performances.
\n\t\t\t\tWe evaluated our results by comparing the candidate word lists that were extracted from the relevant documents using our algorithms with the judgments submitted by our human domain expert. Since not all words on the word lists are likely to be relevant, we varied how many of the top weighted words were used. We chose threshold values t from 0.1 to 1.0 corresponding to the percentage of top candidate words that are extracted (e.g., t=0.1 means that top 10% words are selected). We carried out 6 different tests corresponding to the four candidate lists, i.e.,
F-measure of the tests in Group_A (β=0.25).
The best result was achieved in the test L1N, using the highest weighted nouns extracted from individual documents. By analyzing results, we find that the best performance is achieved with a threshold t=0.6, i.e., the top 60% of the words (277 words total) in the candidate list are used. This threshold produced precision of 88% and recall of 58% meaning that 167 words were added to the ontology of which 147 were correct.
\n\t\t\t\t\tTo confirm our results, we validated the best performing algorithm,
\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t28 | \n\t\t\t\t\t\t\t\t55 | \n\t\t\t\t\t\t\t\t83 | \n\t\t\t\t\t\t\t\t110 | \n\t\t\t\t\t\t\t\t139 | \n\t\t\t\t\t\t\t\t167 | \n\t\t\t\t\t\t\t\t194 | \n\t\t\t\t\t\t\t\t222 | \n\t\t\t\t\t\t\t\t249 | \n\t\t\t\t\t\t\t\t277 | \n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t22 | \n\t\t\t\t\t\t\t\t50 | \n\t\t\t\t\t\t\t\t77 | \n\t\t\t\t\t\t\t\t101 | \n\t\t\t\t\t\t\t\t124 | \n\t\t\t\t\t\t\t\t147 | \n\t\t\t\t\t\t\t\t162 | \n\t\t\t\t\t\t\t\t188 | \n\t\t\t\t\t\t\t\t206 | \n\t\t\t\t\t\t\t\t225 | \n\t\t\t\t\t\t\t
Number of words can be added.
\n\t\t\t\t\t\tTable 3 reports in more detail on the number of candidate words and how many correct words can be added to the ontology through the text mining process with the document-based selection and restricting our words to nouns only, i.e. the L1N test with threshold 0.6 on the validation documents,
The experimental results show that the ontology enrichment process can be used with new relevant vocabularies extracted from both of our approaches of text mining and lexical expansion. Overall, the text mining approach achieved a better result than the WordNet approach. Table 4 shows the performance comparison of these two approaches in their best case.
\n\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t
Precision | \n\t\t\t\t\t\t\t0.74 | \n\t\t\t\t\t\t\t0.88 | \n\t\t\t\t\t\t
Recall | \n\t\t\t\t\t\t\t0.50 | \n\t\t\t\t\t\t\t0.58 | \n\t\t\t\t\t\t
F-Measure | \n\t\t\t\t\t\t\t0.72 | \n\t\t\t\t\t\t\t0.85 | \n\t\t\t\t\t\t
#Candidate Words | \n\t\t\t\t\t\t\t155 | \n\t\t\t\t\t\t\t167 | \n\t\t\t\t\t\t
#Words mined correctly | \n\t\t\t\t\t\t\t115 | \n\t\t\t\t\t\t\t147 | \n\t\t\t\t\t\t
#Words mined incorrectly | \n\t\t\t\t\t\t\t40 | \n\t\t\t\t\t\t\t20 | \n\t\t\t\t\t\t
Comparison of two approaches in the best case.
In the text mining approach, we got the best results using a vector space approach with the document-based selection and restricting our words to nouns only. Overall, our algorithm produced good accuracy, over than 81% for all cases. If we restrict our candidates to only the top-weighted candidates extracted from the documents, the precision is higher but the recall decreases. In the best case, where the F-measure is maximized, the precision is 88% on the test collection. Our algorithm was also validated with another dataset (i.e. documents in
The results in the lexical analysis approach also show that our similarity computation method can provide an effective way to identify the correct sense for words in a given ontology. These senses then provide a source of new vocabulary that can be used to enrich the ontology. Our algorithm was best with the precision of 74% in the method of #Depth+CE. If we consider words with fewer senses, the accuracy of detection of correct words is higher. This level of accuracy was achieved using a reference hypernym tree with 110 hypernyms, built from only 14 manually disambiguated concept-words from the top two levels of our amphibian morphology ontology. From these words, we are able to identify a large collection of synonyms and hypernyms that are a good potential source for the ontology enrichment process.
\n\t\t\tIn previous sections, we have presented our main approaches to mine new relevant vocabularies to enrich a domain ontology from two main sources: (i) the WordNet database; and (ii) domain-relevant documents collected from the Internet. In this section we describe how we enrich the domain ontology by adding these newly-mined words to the appropriate concepts. Our main task in this phase is finding a method to add correctly a new candidate word to the best appropriate ontology concept vocabulary.
\n\t\t\tAs presented in the section 4.1, our lexical expansion approach has identifies the correct WordNet sense for each concept-word and then considering that sense’s synsets and hypernyms as new vocabulary for the associated concept.In the previous phase, we used the hypernyms trees to identify the correct sense for each concept-word. For each correct sense, we add the synonym words (synsets) of that sense to the ontology concept vocabulary. Because we know which concept the synset is associated with, an advantage of this approach is that it is trivial to attach the new vocabulary to the correct concept.
\n\t\t\t\tFrom the 285 correct senses mined in the first phase, our lexical expansion mineda total of 352 new synonym words over 155 concept words that were returned. Many synonym words were duplicates, so we refined the candidate vocabulary by removing redundant words, leaving 321 new words to add to the ontology.
\n\t\t\t\tTo evaluate the accuracy of this approach, we presented each of these 155 word-concept pairings to a human domain expert and asked them to validate whether or not the pairing is accurate. In their judgment, 115 words were relevant to the amphibian morphology domain, and their 260 synonyms words were considered. We then refined these synonym words by removing duplicates. Thus, we ultimately added 231 words to the appropriate concepts, almost entirely automatically. The precision of adding correct synonym words to the ontology was 71.9%. The only manual step in this process is the filtering out of the incorrect word-senses extracted from WordNet.
\n\t\t\tTo reiterate our task, given a list of potential synonyms to be added to an ontology, we want to develop an algorithm to automatically identify the best matching concept for each candidate. Unlike the WordNet approach, this is a much more difficult task for words mined from the literature. The candidate words are domain relevant, but exactly where in the ontology do they belong?We again turn to thedomain-relevant corpus of documents to determine the concept in the ontology to which these newly mined candidate words should be attached. The main differences between our approach and that of others are:
\n\t\t\t\t\tThe documents are used as the knowledge base of word relationships as well as the source of domain-specific vocabulary. Specifically, for each concept (and each candidate word), chunks of text are extracted around the word occurrences to create concept-word contexts and candidate word contexts. The words around each concept and/or candidate word occurrence thus contain words related to the semantics of the concept/candidate word.
Word phrases can be handled. Instead of handling each word in a word phrase separately and then trying to combine the results, as we did with WordNet, we can process the word phrase as a whole. For each word phrase, we extract text chunks in which all of the words occur. Thus, the contexts are related to the concept-word as a whole, not just the individual component words.
The four main steps of our approach are:
\n\t\t\t\t\tExtract text chunks surrounding the concept-word(s) from each input document. Combine the text chunks extracted to create context files that represent the concept. Using the same method, create context files for each candidate word (i.e., potential synonym).
For each candidate, calculate the context-based similarity between the candidate context and each concept context.
Identify the most similar concepts using kNN (k nearest neighbors).
Assign the candidate words to the concept(s) with the highest similarity.
This process begins with a set of domain-related documents that are used as a knowledge base. From each preprocessed text file, we locate all candidate word occurrences and then created windows of plus/minus N words around each occurrence. Overlapping windows are then combined to create non-overlapping text chunks. Because varying numbers of overlapping windows may be combined to create the text chunks, the text chunks vary in size and in the number of word occurrences they contain. In order to illustrate the text chunks selection process, consider a single document representing the concept name “neural_canal” with the query keywords are “neural” and “canal”.
\n\t\t\t\t\ta. Step 1: Identify windows around each query keyword
\n\t\t\t\t\tIn one part of the document under consideration with the window size of +-10, there are three occurrences of both terms “neural” and “canal” and thus three windows of size 21 with a word in the middle. We can see that Windows 1, 2, and 3 all contain keywords and they are overlapping.
\n\t\t\t\t\tWindow 1: (middle keyword is “neural”)
\n\t\t\t\t\tmorphy pronounced reduction process boulengerella lateristriga maculata hypothesized synapomor‐ phic species neural synapomorphy laterosensory canal system body majority characiforms completely developed posterior
\n\t\t\t\t\tWindow 2: (middle keyword is “canal”)
\n\t\t\t\t\tprocess boulengerella lateristriga maculata hypothesized synapomorphic species neural synapomor‐ phy laterosensory canal system body majority characiforms completely developed posterior neural lat‐ erosensory canal
\n\t\t\t\t\tWindow 3: (middle keyword is “neural”)
\n\t\t\t\t\t\nb. Step 2: Combine overlapping chunks of text\n
\n\t\t\t\t\tIn this step, we combine all overlapping windows to create the text chunks as following.
\n\t\t\t\t\tc. Step 3: Combining chunks of text across document
\n\t\t\t\t\tIn this step, we simply combine the text chunks extracted for a given context from a document by appending them together.
\n\t\t\t\tAfter having extracted text chunks surrounding to keyword instances (i.e., concepts or synonyms), we have two sets of contexts: (1)
a. Individual Vector
\n\t\t\t\t\tLet’s take an example of a concept keyword Ck represented by 5 context files extracted from 5 relevant documents (i.e., N=5). This keyword will have 5 individual vectorsrepresenting for each individual context file. We used the KeyConcept package [9] to index features and calculate their weights; each individual vector has the following format:
\n\t\t\t\t\tin which weightij = rtfij * idfj,, the relative term frequency rtfij and the inverse document frequency idfij are respectively calculated by the following formulas
\n\t\t\t\t\tIn our experiments, the document collection we used is very specific to the amphibian morphology domain. In order to make the idf value more fair and accurate, we adopt the idf dataset based on the ODP that we had used in the previous paper [19].
\n\t\t\t\t\tb. Centroid Vectors
\n\t\t\t\t\tThe centroid vector of the concept keyword Ck is calculated based on the individual vectors over N relevant documents.
\n\t\t\t\t\tIn the next sections, we present our methods to calculate the similarity between two sets, i.e., (1) S representing candidate synonyms; and (2) C representing concepts, to create and rank a list of synonym-concept assignments.
\n\t\t\t\t\tSince each context is essentially a collection of text, we use the classic cosine similarity metric from the vector space model to measure the semantic relatedness of two contexts. For each context Sm representing a candidate synonym and Cn representing a concept, the similarity of each pair (Sm, Cn) is the weight of cosine similarity value calculated by the following formula:
\n\t\t\t\t\twhere
\n\t\t\t\t\t\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
Note that these similarity values are normalized by the size of the context.
\n\t\t\t\t\tSince each keyword is presented either by N individual vectors (i.e., N context files) or a centroid vector over N context files, we propose to conduct four different methods to calculate the similarities between candidate synonym vectors and concept vectors:
\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t
Finally, for each candidate synonym it is assigned to the top concepts whose context Cn has the highest similarity values to the context for Sm.
\n\t\t\t\t\tOnce the similarity between each word pair in (Sm, Cn) is calculated, we use the kNN method to rank the similarity computation results. The higher the similarity means the candidate synonym would be closer to the target concept. For each candidate word, we take top k items from the similarity sorted list. Then, we accumulate the weights of pairs having the same concept names. The final ranked matching list is determined by the accumulated weights. We then pick the pairs having highest weights value between Sm and Cn as the potential concepts to which the candidate synonym is added.
\n\t\t\t\ta. Baseline: Existing WordNet-Based Algorithms
\n\t\t\t\t\tWe evaluated four WordNet-based algorithms that had produced high accuracy as reported, i.e., Resnik [27], Jiang and Conrath [13], Lin [16], and Pirro and Seco [26], using all 191 test synonyms in our dataset.
\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\tLIN | \n\t\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t\t9 | \n\t\t\t\t\t\t\t\t11 | \n\t\t\t\t\t\t\t\t12 | \n\t\t\t\t\t\t\t\t13 | \n\t\t\t\t\t\t\t\t13 | \n\t\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t\t
JIANG | \n\t\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t\t7 | \n\t\t\t\t\t\t\t\t7 | \n\t\t\t\t\t\t\t\t9 | \n\t\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t\t11 | \n\t\t\t\t\t\t\t\t11 | \n\t\t\t\t\t\t\t\t11 | \n\t\t\t\t\t\t\t|
RESNIK | \n\t\t\t\t\t\t\t\t2 | \n\t\t\t\t\t\t\t\t9 | \n\t\t\t\t\t\t\t\t9 | \n\t\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t\t15 | \n\t\t\t\t\t\t\t\t16 | \n\t\t\t\t\t\t\t\t16 | \n\t\t\t\t\t\t\t\t16 | \n\t\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t|
PIRRO | \n\t\t\t\t\t\t\t\t1 | \n\t\t\t\t\t\t\t\t3 | \n\t\t\t\t\t\t\t\t4 | \n\t\t\t\t\t\t\t\t5 | \n\t\t\t\t\t\t\t\t9 | \n\t\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t\t10 | \n\t\t\t\t\t\t\t\t12 | \n\t\t\t\t\t\t\t\t13 | \n\t\t\t\t\t\t\t\t13 | \n\t\t\t\t\t\t\t|
\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\tLIN | \n\t\t\t\t\t\t\t\t0.52% | \n\t\t\t\t\t\t\t\t2.09% | \n\t\t\t\t\t\t\t\t2.09% | \n\t\t\t\t\t\t\t\t4.71% | \n\t\t\t\t\t\t\t\t5.76% | \n\t\t\t\t\t\t\t\t6.28% | \n\t\t\t\t\t\t\t\t6.81% | \n\t\t\t\t\t\t\t\t6.81% | \n\t\t\t\t\t\t\t\t7.85% | \n\t\t\t\t\t\t\t\t7.85% | \n\t\t\t\t\t\t\t
JIANG | \n\t\t\t\t\t\t\t\t0.52% | \n\t\t\t\t\t\t\t\t1.05% | \n\t\t\t\t\t\t\t\t1.57% | \n\t\t\t\t\t\t\t\t3.66% | \n\t\t\t\t\t\t\t\t3.66% | \n\t\t\t\t\t\t\t\t4.71% | \n\t\t\t\t\t\t\t\t5.24% | \n\t\t\t\t\t\t\t\t5.76% | \n\t\t\t\t\t\t\t\t5.76% | \n\t\t\t\t\t\t\t\t5.76% | \n\t\t\t\t\t\t\t|
\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t|
PIRRO | \n\t\t\t\t\t\t\t\t0.52% | \n\t\t\t\t\t\t\t\t1.57% | \n\t\t\t\t\t\t\t\t2.09% | \n\t\t\t\t\t\t\t\t2.62% | \n\t\t\t\t\t\t\t\t4.71% | \n\t\t\t\t\t\t\t\t5.24% | \n\t\t\t\t\t\t\t\t5.24% | \n\t\t\t\t\t\t\t\t6.28% | \n\t\t\t\t\t\t\t\t6.81% | \n\t\t\t\t\t\t\t\t6.81% | \n\t\t\t\t\t\t\t
Evaluation of WordNet-based algorithms.
Our baseline approach using WordNet was complicated by the fact that it does not contain word phrases, which are very common in the concepts and synonyms in our ontology. We separate each word phrase (e.g., neural_canal) into single words, e.g., neural and canal, then submit each to WordNet to calculate the similarity. Then, we add together the individual word similarity score to produce the total similarity value for each phrase. For each of the 191 synonyms in the test set, the similarity between that synonym and each of the 530 concept names pairs was calculated, and then the concepts were ranked in decreasing order by similarity. Table 5 presents the accuracy for each method at different cutoff points in the list.
\n\t\t\t\t\tFrom the Table 5, we can see that Resnik’s algorithm works best with this test set, although is only 1.05% accurate at the rank 1 location and 8.9% the correct concept appeared within the top 10 ranked concepts. The other approaches are not as accurate.
\n\t\t\t\t\tb. Context-Based Algorithms
\n\t\t\t\t\tWe evaluated results by comparing the list of top ranked concepts for each synonym produced using our context-based method with the truth list we extracted from the ontology. The performance is reported over varying text chunk sizes (or text window sizes -
Result of the context-based similarity computation methods
By analyzing results, we find that the best performance is achieved in the Indi2Indi method with the window size (wsize) 4 and the k value 30 (c.f. Figure 9). Other methods slightly performed less well than the Indi2Ind. When the window size is increased, the performance is not improved.
\n\t\t\t\t\tc. Comparison with Baseline
\n\t\t\t\t\tFrom the above charts (c.f. Figure 9), we found that the context-based method works better with small text window size (i.e. size=4, 6). We evaluated the same reported pairs of synonym and concept-words with our text mining methods and the above WordNet-based algorithms. Figure 10 shows that our context-based similarity computation methods consistently outperform the best WordNet-based algorithm. Even the less promising
The experimental results support our belief that we might not need to rely on the WordNet database to determine similar words. The WordNet-based algorithms have not provided high precision results since many words are compound and/or do not exist in the WordNet database.
\n\t\t\t\t\tComparison of our context-based methods vs. WordNet-based algorithms
Our context-based approach was evaluated using synonyms from the amphibian ontology itself as our truth dataset. The experimental results show that our text mining approaches outperform the common similarity calculation algorithms based on WordNet in terms of correctly adding new words to the ontology concepts. Our best algorithm, Indi2Indi, with a window size of 4 and k=30 for kNN, selected the correct concept within the top 10 concepts 19.37% of the time. In comparison, the best WordNet-based algorithm only achieved 8.9% on the same task.
\n\t\t\t\tOverall, using WordNet similarity algorithms to assign a new vocabulary to an existing ontology might not be an effective solution since it depends on the WordNet database. One of the main drawbacks of the WordNet database is the unavailability of many words, particularly for narrowly-defined domains. Another problem with WordNet-based algorithms is that, because WordNet is so broad in scope, an extra step is neededfor semantic disambiguation thatcan further decrease accuracy.In contrast, the text mining approach can be applied to any domain and can use information from the Internet to mine new relevant vocabularies.
\n\t\t\t\tCompared with the lexical expansion approach, in terms of correctly assigning new words to specific ontology concepts, both context-based and WordNet-based text mining algorithms have lower precision (19.37% and 8.9% vs. 71.9%). This difference is to be expected because, with the lexical expansion approach, we already know the concepts to whichthe new words are to be attached.With that process, we start with a concept and try to find relevant domain-specific words.In contrast, the text mining approach starts with domain-relevant words and then tries to find matching concepts.
\n\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t
# Total words | \n\t\t\t\t\t\t\t321 | \n\t\t\t\t\t\t\t191 | \n\t\t\t\t\t\t\t191 | \n\t\t\t\t\t\t
# Correct words added | \n\t\t\t\t\t\t\t231 | \n\t\t\t\t\t\t\t17 | \n\t\t\t\t\t\t\t37 | \n\t\t\t\t\t\t
Precision | \n\t\t\t\t\t\t\t71.9% | \n\t\t\t\t\t\t\t8.9% | \n\t\t\t\t\t\t\t19.3% | \n\t\t\t\t\t\t
Comparison of different approaches on number of words added and accuracy.
\n\t\t\t\t\tTable 6 summarizes the results for the various approaches.It is clear that, in spite of the difficulty in finding domain-specific words in WordNet, the lexical expansion approach achieves both the best ontology enrichment, both in terms of the number of words added to the ontology and the quality of those additions.
\n\t\t\tThe goal of this research study is to implement and validate an ontology learning framework in order to enrich the vocabulary of the domain ontology from Web documents related to the domain and from the WordNet semantic lexicon. We have presented two approaches, i.e., lexical expansion using WordNet and text mining, to perform these tasks. In the first approach, we built a reference hypernym tree by manually disambiguating top two levels of concepts from the ontology and compared three similarity computation methods to allow us to disambiguate the other concept-words in the ontology using WordNet. For the correct sense, we then enriched the corresponding concept with its synonyms and hypernyms. In our second approach, we implemented a focused crawler that retrieved documents in the domain of amphibian morphology that incorporates an SVM-based filter. The most relevant documents are submitted for information extraction using text mining.
\n\t\t\tOur approaches were empirically tested based on the seed amphibian ontology with WordNet lexical synsets and with retrieved Web document. While both approaches performed well, the text mining approach had higher precision for extracting relevant vocabulary to enrich the ontology. However, that approach had greater difficulty attaching the new vocabulary to the correct concept. Considering the ultimate utility of these two approaches, the text mining approach depends on the number and quality of the documents collected by the topic specific crawler. In addition, although it extracts good words, these words are not matched with particular concepts within the ontology. A further pairing process, most likely involving WordNet, is needed to complete the ontology enrichment process. In contrast, the lexical expansion approach using WordNet is only dependent on the concept-words in the ontology itself. It also extracts words from WordNet on a concept-by-concept basis, so no extra process is required to match new words with concepts. However, it does suffer from inaccuracies when the incorrect senses of words are used for expansion. It also requires a small amount of manual effort in order to disambiguate a few concept-words in order to construct the reference hypernym tree.
\n\t\t\tIn future, we hope to combine these two approaches to exploit the strengths of each. For example we can use WordNet pair the text mining with concepts and use the documents to identify and disambiguate the multiple senses for the concept-words found in WordNet. In order to mine more vocabularies for the ontology, we will deal with the concept-words that currently do not appear in WordNet due to the very narrowness of the domain. Our other main task is to validate our approach on ontologies from other domains, to confirm that it is domain-independent. Finally, we need to incorporate the results of this work into a complete system to automatically enrich our ontology.
\n\t\tThis research is partially supported by the NSF grant DBI-0445752: Semi-Automated Construction of an Ontology for Amphibian Morphology.
\n\t\tA wound is any type of injury which can be in the form of a cut, bruise or contusion caused by some external force. Open wounds are susceptible of getting infected by microorganisms like bacteria, virus or fungi if left unattended. Infected wounds pose a major challenge for healthcare system due to its direct relation with mortality and morbidity of the affected patients [1]. When a wound is infected it causes stress (physiological and psychological) and slows down the wound healing process and in some cases worsens the situation [2]. Approximately 2% of all hospitalized patients worldwide have a chronic wound, and older adult patients are at highest risk, because aging impairs the healing process [3, 4]. As many as 70% of these wounds recur, and 34% are accompanied by infection [5]. A survey by Medicare beneficiaries in 2018 stated that approximately 8.2 million individuals were having some kind of wounds, with or without infection and they estimated the treatment cost to be near about 28.1 billion to 96.8 billion dollars making it a big economic challenge as well [6]. Infectious wounds like surgical wounds, diabetic foot and ulcer are more problematic and are reported more frequently than other infectious wounds [7]. Silver since time memorial is used for its good antimicrobial potential due to its interference with the thiol group of the microbial membrane. It also increases production of reactive oxygen species with in the microbe resulting in damage of DNA and bacterial proteins [8]. Due to its broad spectrum antimicrobial activity, silver nanoparticles are getting a great attention especially in the form of dressing for the infected wounds. This chapter will throw light on the various applications and recent trends in the health care system for treatment of infectious wounds using silver nanoparticles.
In general, any form of breakage or harm to the surface of skin can be termed as a wound and broadly classified into two types i.e. acute wound and chronic wound. An acute wound is one in which the wound physiology tends to remain normal during the process of healing. Acute wounds are usually bites, minor burns, cuts and surgical wounds. It is seen that such kind of wounds heal within a predictable timespan depending upon the location, depth and type of wound. In case of chronic wounds the physiology of the wound is disturbed due to various endogenous mechanisms which results in damaging the integrity of the tissue. Examples of chronic wounds are ulcers, diabetic foot and pressure sores. These types of wounds aggravate by aging, malnutrition, diseases which results in immunosuppression within the patient like AIDS or in patients on immunosuppressant drugs [9, 10]. Wound is said to be infected when there is entry of a microbe from the breached skin, which slows down the healing process and results in appearance of signs and symptoms like pain, discoloration of the wounded area, edema, puss, abnormal smell, tenderness etc. [11]. Most of the hard to heal infected wounds are observed to possess biofilms in them [12]. Biofilms are surface linked microbial structural communities having sessile cells present in the matrix produced by the microbe itself, made of polysaccharides, deoxyribonucleic acid and other components which are an essential type of adaptation strategy for the survival of bacteria as it protects it from the harsh surroundings and several immune responses by the extracellular polymeric substance (EPS) [13]. Bacteria possessing biofilms has increased chance of gene transfer of antibiotic resistance gene to other bacterial species [14, 15]. Bacteria having biofilms are tough to treat even with higher doses as biofilms prevent antimicrobial agents to reach up to bacteria [16, 17]. Although there are many beliefs regarding the defensive mechanism of biofilms against the antimicrobial agents but till date its nature of defense is unknown [18].
Replacement of damaged tissue by newly produced tissue is termed as wound healing [19]. Skin (epidermis and dermis) acts as a protective layer against the harsh environment and when this barrier is breached a sequence of biochemical events takes place to repair the damage [19, 20]. The process of wound healing is generally described in four phases i.e. blood clotting, inflammation, tissue growth and tissue remodeling [21]. In the first phase with in some time platelets starts covering the area of the affected site. They release a particular chemical signal which promotes clotting resulting in activation of fibrin which produces a mesh to which platelets bind and forms a clot. This phase is also known as hemostasis [22, 23]. In second phase or inflammation stage clearing of debris and bacterial cells takes place via process of phagocytosis where white blood cells and macrophages engulf and destroys them [24]. In the next phase that is proliferation phase or tissue growth phase angiogenesis, collagen deposition, granulation tissue formation, epithelialization and wound contraction takes place [25]. At last the tissue enters the maturation or the remodeling phase in which collagen is realigned and the cells which are not needed are removed by apoptosis [26].
Since early times silver appeared in recorded history texts for its excellent antimicrobial action. The ancient Greek historian ‘Herodotus’ describes that at the times of war Persian kings among with his provisions used to take boiled water from silver jars [27, 28]. Raulin in 1869 was the first person who observed the antimicrobial activity of silver by observing that
Any small particle which ranges between 1 to 100 nanometers (10−9) in size is known as a nanoparticle. It cannot be detected with naked human eye and it exhibits different chemical and physical properties in comparison to their large material counterparts [36]. Among many inorganic nanoparticles, silver nanoparticles (AgNPs) have got researchers attention around the globe due its novel physical, chemical and biological properties as compared to their bulk form. They have particular chemical and physical properties like high electrical and thermal conductivity [37], surface enhanced Raman scattering effect [38], catalytic activity [39], chemical stability [40] and nonlinear optical behavior [41]. The above stated properties make it the material of choice to be used in electronics, and for medical use. Silver nanoparticles are also known for their antiviral, antibacterial and antifungal activity. Due to smaller size, surface area to volume ratio is increased which results in increase in the amount of atoms on the surface, that other forms. The net effect gives rise to unpredictable properties associated with nanoparticles [42]. Silver nanoparticles has shown proven antimicrobial activity in many in vivo and in vitro studies and have application in soaps, cosmetics, food packaging and wound dressing [43]. Due to epidermal keratin and phospholipids, and protein thiol groups, skin was thought to be impermeable to silver nanoparticles but some studies demonstrated, if any absorption beyond the stratum corneum [44, 45]. Silver wound dressings are in direct contact with damaged skin resulting in systemic absorption also associated with some toxicity [46].
In an average human concentration of silver in plasma is less than 2 μg/mL which is derived from inhalation of particulate matter and diet [44]. Silver can enter human body by inhalation, oral ingestion and dermal absorption [34]. Pinocytosis and endocytosis are believed to be two processes by which the silver nanoparticles may enter the body. It is seen that the particles that are of nanoscale penetrate much deeper than those of regular size leading to a novel delivery therapy [47, 48]. Till now exact mechanism of action of silver nanoparticles is not clear but several actions have been proposed by the scientists for its antimicrobial activity. Continual release of silver ion is considered to be the main reason for its antimicrobial activity [49]. Due to sulfur protein affinity and electrostatic attraction silver ions adhere to the wall of cells and cytoplasmic membrane which increases its permeability and penetrability into the cytoplasmic membrane leading to disruption of the bacterial cell wall [50]. When the silver ion enters the cell it can deactivate the respiratory enzymes and can generate reactive oxygen species [51]. Reactive oxygen species acts as a key component and a major reason for cell membrane disruption and DNA damage (by interacting with sulfur and phosphorus of DNA) causing problem in DNA replication, reproduction results in death of the microbes. Silver ions also inhibit the synthesis of proteins by denaturation of ribosomes and cause interruption the production of ATP [52]. After anchoring the surface of the cell silver nanoparticles gets accumulated in the pits of the cellular wall of microbe resulting in cell membrane denaturation [53]. Due to nanosize they easily penetrate cell membrane, leading to rupture of cell organelles and even lysis. They also affect the bacterial transduction process by interfering with the phosphorylation of protein substrates which can result in cell apoptosis and cell multiplication [53, 54]. Gram-negative bacterial strains are more sensitive towards the effect of silver nanoparticles because the cellular walls of these bacteria are narrower than the gram positive bacteria [55]. One drawback of silver nanoparticles is that they are not much effective in the case of bacteria having biofilms. Biofilms protects the membrane from both nanoparticles and silver ions by altering their transport due to its complicated structure [56]. The pathway of the nanoparticles penetration is highly obstructed if the size is grater that 50 nm [57]. It is also observed that adsorption and accumulation of the silver nanoparticles on the biofilm results in reduced diffusion of nanoparticles in bacteria [58].
A dressing is a sterile material applied to a wound to promote healing and protect the wound from further harm [59, 60]. It has been designed in such a way that it is in direct contact with the wound, as distinguished from a bandage, which is most often used to hold a dressing in place. Silver dressings are used for both types of wounds (acute and chronic) and when there is risk of high level of bio burden or local infection for example in the case of burns [61]. Silver dressings helps in reducing the bioburden in infected or colonized wounds and also acts as a barrier to reduce any further chance of infection [62].
There are four types of silver nanoparticles synthesis, namely chemical, irradiation, green and thermal. In chemical synthesis, two types of synthesis methods are used which are Brust-Schiffrin synthesis which is mainly used for golden nanoparticles and Turkevich method which is based on reduction of the boiling solution of silver salt with citrate salt solution [63, 64]. Irradiation synthesis is connected with radiation of precursors or intermediate products of reaction with electromagnetic radiation with different wavelengths [65, 66, 67]. In green synthesis plant, fungus or bacterial extract is mixed with silver ion usually silver nitrate, the bioactive molecules of extracts reduce silver ion to elementary silver and then it is precipitated in alcohol. Advantages of this synthesis are that cost involved in synthesis is low, environment friendly and plant extracts contain medicinal compounds which are used in conventional medicine [68, 69, 70, 71, 72, 73, 74, 75, 76, 77]. Thermal synthesis is based on the principle of thermal reduction of silver salt. After the synthesis of the silver nanoparticles, they are incorporated in membrane or composite material, nanofibers, hydrogels, etc. and are used as a wound dressing.
Membrane and composite material-immobilized nanoparticles can have many functions including antimicrobial activity. Silver nanoparticles incorporated in membranes like polyethersulfone, acetate cellulose, polydopamine-coated poly(ether imide) etc. showed significant antimicrobial activity against diverse range of microbes thus have capability to sterile wound environment and promote healing process [78], representative examples are summarized in Table 1.
Polymer used | Method of preparation of nanoparticles | Size (nm) | Result |
---|---|---|---|
Bacterial cellulose | Thermal method (thermal reduction at 80o C | 10–30 | Reduction seen in |
Chitin | Irradiation method, (gamma rays, 60Co) | 3–13 | Significant bactericidal effect (p < 0.01) [80] |
Bacterial cellulose | Green method (cellulose from | 50–150 | Strong activity against |
Chitosan, Polyvinyl alcohol, Curcumine | Green method (chitosan) | 16 | Significant effects against |
Chitosan and Chitin | Green method ( | 60–150 | Good healing activity [83] |
Konjac Glucomannan | Green method (egg white) | 8–32 | Accelerates wound healing and fibroblast growth promotion [84] |
Bacterial cellulose | Chemical method (NaBH4) | 3–17 | Inhibiton of growth of |
Chitin | Chemical method (sodium citrate) | 5 | Inhibiton of growth of |
Poly vinyl pyrrolidine chitosan | Chemical method (sodium citrate) | 10–30 | Reduces growth of |
Chitosan | Chemical method (NaBH4) | 15 | Facilitates cell proliferation and mitigate bacterial infection [88] |
Bacterial cellulose | Chemical method (NaBH4) | 5–14 | Inhibition of growth of |
Silver nanoparticles based membrane composites for wound management.
Powdered silver nanoparticles are used for incorporation into different types of clothing and dressings. Representative examples are summarized in Table 2.
Material used for preparation of clothing and dressings | Method of preparation of nanoparticles | Size (nm) | Result |
---|---|---|---|
Cotton fabrics | Chemical method (alkali solution of starch) | 22–24 | Inhibition of growth of |
Dressing material | Chemical method (NaBH4) | 4–24 | Reduction in wound inflammation and fibrogenic cytokines modulation [91] |
Cotton fabrics | Green method ( | 2 | Reduction of growth on |
Silver nanoparticles incorporated wound dressing | Green method ( | 200–800 | Effective wound healing activity [93] |
Silver nanoparticles incorporated clothing and dressings for wound management.
Nanofibers are emerged as an important structures with wide range of biological as well as physical applications like air filtration, immunoanalysis and as pseudo-enzymes etc. [81, 82, 83, 84, 94, 95]. Apart from that active research is also ongoing for utilization of silver nanoparticles incorporated nanofibers for wound management. Examples of nanofibers are given in Table 3.
Polymer used for preparation of nanofibers | Method of preparation of nanoparticles | Size (nm) | Result |
---|---|---|---|
Collagen | Chemical method (sodium citrate) | 25–55 | Accelerated wound healing [96] |
Poly vinyl pyrrolidine | Chemical method (N,N- DMF) | 3–5 | Effective antibacterial action [97] |
Poly methyl methacrylate-co-dopamine | Chemical method (Silver ion dipped in PMMDM) | <20 | Effective antibacterial and wound healing action [98] |
Plumbagine | Chemical method (PBG reduction) | 60 | High antibacterial activity [99] |
Gelatine | Chemical method (Silver nitrate reduced with gelatin powder) | 11–20 | High anti antibacterial activity against Gram positive bacteria [100] |
Poly ethylene oxide poly caprolactone | Chemical method (Silver nitrate reduced with PEO and DMF) | 13–17 | Good antibacterial potential [101] |
Alginate | Chemical method (NaBH4) | 5–17 | Reduces the inflammatory phase and increased epidermal thickness [102] |
Chitosan, glucose, Poly vinyl alcohol | Green method (chitosan, glucose) | 10–30 | Good antibacterial activity against gram negative bacteria [103] |
Poly galacturonic acid | Green method (PGA, HA) | 5–13 | Maximum wound epithelization and collagen deposition [104] |
Poly caprolactone | Green method ( | 5–20 | Excellent antibacterial activity against |
Poly vinyl alcohol | Irreadiation method | 23–24 | Significant antibacterial activity against |
Silver nanoparticles incorporated nanofibers for wound management.
Hydrogels have excellent capacity to absorb wound exudates and at the same time maintain the moisture in wound environment to ensure proper healing. Hydrogels form impermeable physical barrier on wound surface and prevent bacterial invasion (Figure 1) and apart from that hydrogels also showcased its tendency to absorb wide range of metals [59, 96, 107, 108]. Some silver nanoparticles incorporated hydrogels showed excellent wound healing activity as shown in Table 4.
Schematic layout of hydrogel membrane reducing bacterial invasion and accelerating wound healing process.
Polymer used for preparation of hydrogels | Method of preparation of nanoparticles | Size (nm) | Result |
---|---|---|---|
Poly acrylic acid and poly vinyl alcohol | Chemical method (NaBH4) | 2–3 | Significant antibacterial activity against |
Beta- chitin | Chemical method (sodium citrate) | 4–8 | It showed inhibitory effects on the bacteria growth [110] |
Chitosan | Green method (sericin and chitosan) | 240–970 | Bactericidal action [111] |
2-acrylamide-2-methylpropane sulphonic acid sodium salt | Irradiation method (UV radiation) | — | Used as a burn wound dressing due to its good antibacterial activity [112] |
Poly vinyl alcohol | Irradiation method (UV radiation, gamma rays 60Co) | 90 | Antimicrobial activity against |
Collagen | Thermal method (reduction at 40°C | 5–14 | Antimicrobial activity against |
Carboxymethylcellulose | Thermal method (reduction at 70–100°C | 7–21 | Removes the exudates and prevents wound maceration [115] |
Silver nanoparticles incorporated hydrogels for wound management.
Silver nanoparticles functionalized wound dressings have significant antimicrobial activity and provide faster and effective tissue repair thus they are widely explored for wound healing activity. Beside this they are far away from clinical practice as well as commercialization. More rigorous preclinical investigations are still required to validate their capability for tissue regeneration. Apart from that work is also needed to be done on industrial scale up techniques for commercialization.
Nanomaterial’s now a days representing potential ways for combating microbial related diseases and disorders. Wounds especially chronic ones burdened with resistant microbes are posing serious challenge to healthcare system. For that purpose silver nanoparticles impregnated wound dressing due to their excellent antimicrobial potential are not less than a boon. Along with sterilization they are proven to fasten tissue repair in wounds. Presently more rigorous efforts are needed in their preclinical investigations to evaluate their efficacy verses safety ratio. They have capability to become potential wound dressing of future.
The authors are also thankful to Guru Nanak Dev University, Amritsar for providing various facilities to carry out the work.
The authors declare no conflict of interest.
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