Mutual inductance measurements.
\r\n\tThe purpose of the book is to bring together the latest knowledge about genetic diversity by presenting the studies of some of the scientists who are engaged in development of new tools and ideas used to reveal genetic diversity, often from very different perspectives. The book should prove useful to students, researchers and experts in the area of biology, medicine and agriculture.
",isbn:"978-1-80356-945-1",printIsbn:"978-1-80356-944-4",pdfIsbn:"978-1-80356-946-8",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"0b1e679fcacdec2448603a66df71ccc7",bookSignature:"Prof. Mahmut Çalışkan and Dr. Sevcan Aydin",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11643.jpg",keywords:"PCR Based Methods, Protein Based Methods, Sequencing, Conservation of Genetic Resources, Natural Variation, Molecular Markers, Genetic Manipulation in Animals, Resistance to Disease, Genetic Manipulation in Plants, Use of Microorganisms in Biotechnology, Genetic Differentiation, Gene Therapy and Gene Editing",numberOfDownloads:16,numberOfWosCitations:0,numberOfCrossrefCitations:0,numberOfDimensionsCitations:0,numberOfTotalCitations:0,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 7th 2022",dateEndSecondStepPublish:"June 16th 2022",dateEndThirdStepPublish:"August 15th 2022",dateEndFourthStepPublish:"November 3rd 2022",dateEndFifthStepPublish:"January 2nd 2023",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"2 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Professor of genetics and molecular biology and Head of Biotechnology division at İstanbul University in Turkey whose main research areas include plant molecular genetics, microbial biotechnology and characterization and biotechnological use of halophilic archaeal strains.",coeditorOneBiosketch:"Associate Professor of Biotechnology Division in Department of Biology at Istanbul University in Turkey whose main research areas include genetics, environmental biotechnology and bioengineering.",coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"51528",title:"Prof.",name:"Mahmut",middleName:null,surname:"Çalışkan",slug:"mahmut-caliskan",fullName:"Mahmut Çalışkan",profilePictureURL:"https://mts.intechopen.com/storage/users/51528/images/system/51528.png",biography:"Mahmut Çalışkan is a Professor of Genetics and Molecular Biology in the Department of Biology, Biotechnology Division, Istanbul University, Turkey. He obtained a BSc from Middle East Technical University, Ankara, and a Ph.D. from the University of Leeds, England. His main research areas include the role of germin gene products during early plant development, analysis of genetic variation, polymorphisms, and the characterization and biotechnological use of halophilic archaea.",institutionString:"Istanbul University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"8",institution:{name:"Istanbul University",institutionURL:null,country:{name:"Turkey"}}}],coeditorOne:{id:"462767",title:"Dr.",name:"Sevcan",middleName:null,surname:"Aydin",slug:"sevcan-aydin",fullName:"Sevcan Aydin",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003QRfRpQAL/Profile_Picture_2022-03-24T08:49:06.jpg",biography:"Sevcan Aydın is an Associate Professor of Biotechnology Division in Department of Biology at Istanbul University in Türkiye. She obtained her bachelor's degree from Biology Department of Ege University. She obtained her Ph.D. in Biotechnology Programme of Istanbul Technical University. 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Halil Kavakli and Gul Cevahir Oz",coverURL:"https://cdn.intechopen.com/books/images_new/5508.jpg",editedByType:"Edited by",editors:[{id:"51528",title:"Prof.",name:"Mahmut",surname:"Çalışkan",slug:"mahmut-caliskan",fullName:"Mahmut Çalışkan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4534",title:"Molecular Approaches to Genetic Diversity",subtitle:null,isOpenForSubmission:!1,hash:"47e298294c997622c48b72b4f6d06f41",slug:"molecular-approaches-to-genetic-diversity",bookSignature:"Mahmut Caliskan, Guul Cevahir Oz, I. Halil Kavakli and Birguul Ozcan",coverURL:"https://cdn.intechopen.com/books/images_new/4534.jpg",editedByType:"Edited by",editors:[{id:"51528",title:"Prof.",name:"Mahmut",surname:"Çalışkan",slug:"mahmut-caliskan",fullName:"Mahmut Çalışkan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7947",title:"The Recent Topics in Genetic Polymorphisms",subtitle:null,isOpenForSubmission:!1,hash:"d77e0df1c9ae7d3721747744650bfcd3",slug:"the-recent-topics-in-genetic-polymorphisms",bookSignature:"Mahmut Çalışkan, Osman Erol and Gül Cevahir Öz",coverURL:"https://cdn.intechopen.com/books/images_new/7947.jpg",editedByType:"Edited by",editors:[{id:"51528",title:"Prof.",name:"Mahmut",surname:"Çalışkan",slug:"mahmut-caliskan",fullName:"Mahmut Çalışkan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10886",title:"Genetic Polymorphisms",subtitle:"New Insights",isOpenForSubmission:!1,hash:"a71558dd7dfd16ad140168409f887f7e",slug:"genetic-polymorphisms-new-insights",bookSignature:"Mahmut Çalışkan",coverURL:"https://cdn.intechopen.com/books/images_new/10886.jpg",editedByType:"Edited by",editors:[{id:"51528",title:"Prof.",name:"Mahmut",surname:"Çalışkan",slug:"mahmut-caliskan",fullName:"Mahmut Çalışkan"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6694",title:"New Trends in Ion Exchange Studies",subtitle:null,isOpenForSubmission:!1,hash:"3de8c8b090fd8faa7c11ec5b387c486a",slug:"new-trends-in-ion-exchange-studies",bookSignature:"Selcan Karakuş",coverURL:"https://cdn.intechopen.com/books/images_new/6694.jpg",editedByType:"Edited by",editors:[{id:"206110",title:"Dr.",name:"Selcan",surname:"Karakuş",slug:"selcan-karakus",fullName:"Selcan Karakuş"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"38774",title:"Evaluation of Maximum Voltage or Maximum Link Distance on Implantable Devices",doi:"10.5772/48648",slug:"evaluation-of-maximum-voltage-or-maximum-link-distance-on-implantable-devices",body:'The current technology allows the implementation of electronic devices under the skin for therapeutic purposes. As a result the wireless technology can be used to monitor some illness and mitigate the patient`s discomfort. As an example, consider the case of diabetes patients that must undergo to daily painful blood collections to monitor the blood sugar levels. Therefore an electronic device capable of measuring the blood sugar level and transmit the result to an external device would greatly improve the quality of life of those patients. Nevertheless, the placement of an implantable device requires a minor surgery.
Once the implantable device is placed in a subject, the battery lifetime and its charge will dictate the system lifespan [1].
Consequently, it could be used the passive target technology, in which the device contains its own energy source. Thus the limitation imposed by batteries would not exist in addition to size reduction to the device. The radio frequency identification – RFID technology fits perfectly into that application.
An important parameter to be analyzed is the operation frequency. The communication frequency between the external reader and the implantable device should suffer the smallest interference due to the human tissue. The frequency of 13.56 MHz offers low attenuation and can be chosen for implantable devices. This chapter discusses the energy transfer from reader to tag by inductive coupling and its limitations. It presents a way to evaluate the target voltage provided by the inductive coupling by using basic circuit theory.
Figure 1 shows a typical inductive coupling system. Observe that the system is composed by the reader and the tag. The reader is used to receive data from the tag and also to transfer energy to it.
It is chosen series resonance configuration, as shown in Figure 2, in order to raise the voltage at inductor L1, since voltage in a series resonance inductor is larger than the voltage provided by the source. From basic circuit theory and by observing Figure 3, the impedance seen by the reader is given as:
Typical inductive coupling system.
Simplified inductive coupling circuit at the reader.
The resonance, for low frequency operation, is given as:
However impedance Z becomes resistive and equal to
At this point it is important to define the quality factor of the resonant circuit,
The reader receives data and power by the inductive coupling through
A current flowing in a straight infinite conductor generates a magnetic flow density (or magnetic induction) proportional to the current. That relationship was observed by Biot Savart, as given by (5).
where:
From (5), there will be a magnetic flow area around the conductor. The magnetic flow is given by (6)
where:
In that line, the magnetic flow is proportional to the current flowing in the conductor and there is a linear relationship between them, known as inductance, as shown by (7).
The premise of infinite and straight conductor of the Biot Savart law is not obeyed in the construction of inductors, thus the inductance parameter of a component will depend on many factors such as geometric shape, number of coils and resistance of the conductor.
Whenever two inductors are close, the magnetic flow generated by one influences the flow in the other, as indicated in Figure 3.
Simplified inductive coupling.
Therefore, a time varying current i1 flowing on inductor 1 generates a magnetic flow 21 into inductor 2. The density of magnetic flow that reaches inductor 2 depends on the position and distance between the inductors. Thus mutual inductance is defined as the number of coils of inductor 2 that receives the magnetic flow generated by inductor 1, divided by current i1, as shown by (8).
where :
12 is the magnetic flow on inductor 2 due to inductor 1,
M is mutual inductance between inductors 1 and 2.
If there is any current on inductor 2, the same phenomenon occurs, as given by (9).
Consider two inductors of length D and sectional areas A1 and A2, much smaller than D, number of coils N1 and N2 for inductors 1 and 2, respectively, and placed on the same vertical axis, as shown in Figure 4. As can be observed, inductor 1 is placed inside inductor 2 and they have the same orientation. If it is applied a current into inductor 2, the mutual inductance is given by (9).
Long inductors coupled on the same axis.
If the magnetic field is uniform inside inductor 2, then flow 12 can be taken as (10).
Expression (10) can be placed into (9), as:
By considering that the inductors core is air and the coils are composed of close and simple layers, the Biot e Savart expression can be used, where:
Thus, by combining (11) and (12):
From the analysis of (13) it can be observed that for the auto inductance, the number of coils is the same, thus the expression becomes:
For the inductor, the coupling will be taken in its own area, meaning that they are equal, thus:
By combining (15) and (16), one obtains:
In real case, areas A1 and A2 are not equal, indicating that the magnetic flow is not covered completely by both inductors. Therefore, the coupling factor is reduced, as given by:
where k is the magnetic coupling factor.
Although we have discussed inductive coupling between reader and target, at resonance, that characterize a double resonance, we can use simple resonance. In this configuration the reader presents just an inductor magnetically coupled to the inductor at the tag. The simplified circuit is shown in Figure 5. Observe the resonant circuit is positioned at the tag. In order to simplify the analysis, consider the circuit in free space. By considering also inductors without loss, the circuit of Figure 5 can be equated by using (2), resulting into (19) and (20).
Inductive coupling with simple resonance at the tag.
where M is the mutual inductance between inductors L1 and L2.
From (20):
Now, replacing (22) into (19):
Thus, the impedance seen by the generator is:
From the analysis of (24), it can be observed that the inductance seen by the reader is inductance L1 added to impedance Za reflected from the target, and represented by:
Therefore, by using the same analysis, the impedance Zb reflected on inductor L2 is:
The equivalent circuit reflected at the target is shown in Figure 6.
Equivalent circuit reflected at the inductor L2.
By considering the equivalent circuit at resonance, then:
From the development of (27):
From (28), the resonance frequency is given as:
Thus the resonance frequency at the target was modified by the term r given by:
Consequently, the resonant frequency varies according to the coupling factor k. Thus, the distance between the inductors and their relative orientation can modify the amount of energy transferred by the inductive coupling. In order to validate equation (29), it was run a Spice simulation with a coupling factor ranging from 0.1 to 0.3, as shown in Figure 7. It can be observed that resonance frequency increases along with the coupling factor. As an initial condition, L1 and L2 were taken as 3,5 H and capacitor C1 equals to 38 pF. Observe, from Figure 7, that voltage on inductor L increases along with the coupling factor.
Spice simulation of coupling factor.
There are two tuned circuits in the double resonance, where the primary is the reader and the secondary is the tag. Figure 8 presents the basic configuration for the double resonance inductive coupling.
Double resonance inductive coupling.
From the analysis of Figure 8 and by considering free space and inductors without loss, then:
From (32) it can be obtained that:
By replacing (33) into (31) one obtains:
Therefore, the impedance seen by the generator is:
It can be rewritten as:
Expression (36) allows the behavior analysis of the impedance at the generator, as shown in Figure 8. As previously shown, the mutual inductance depends on the coupling factor. Therefore, it can be verified the influence of the coupling factor in the response of a double tuned circuit. It was run a Spice simulation, as shown in Figure 9, where the coupling factor ranged from 0.1 to 0.2, and the frequency varied from 12 to 16 MHz. As an initial condition, L1 and L2 were taken as 3,5 H and capacitors C1 and C2 are equal to 38 pF. In that case, the resonance frequencies at primary and secondary are equal and it will be taken as an individual resonance.
Spice simulation of double resonance.
From Figure 9 it can be observed that larger coupling factor causes larger deviation of the resonance frequency from the individual frequency. The energy transfer by RF coupling is directly dependent on the variation of the coupling and consequently dependent on the approaching between reader and tag, in other words orientation of the reader and tag inductances strongly changes the double resonance between reader and tag.
According to [3] and [4], the mutual inductance between two inductors can be measured. Considering two magnetically coupled inductors, as shown in Figure 10, the inductance seen by the generator is given as:
Magnetically coupled circuits.
Thus, the inductance seen at the generator terminals is the inductance plus the mutual inductance of inductor 1 over inductor 2, plus the mutual inductance of inductor 2 over inductor 1. Now, considering the series association, as shown in Figure 11, the total inductance is given as:
Series association of inductors.
If inductances L1 and L2 are associated in series, as shown in Figure 11, the resulting inductance is the sum of the individual inductance and the mutual inductances. If the measurement method is altered, as shown in Figure 12, where one inductor is inverted, the new series inductance is given as:
Series association of inductors, in which one inductor is inverted.
Now, subtracting L’ from L’’ results:
By considering M12 = M21 =M, then:
Once L1 and L2 are known, the coupling factor can be found as:
The energy transfer between reader and tag in free space can be modeled using the classic circuit theory. Consider Figure 13 that represents the magnetic coupling between reader and tag.
Magnetic coupling between reader and tag.
Observe that resistor R2 represents the losses on L2, Rtag represents the load at the tag and R1 represents the losses at inductor L1. The analysis can be greatly simplified if the reader circuit can be converted into the series equivalent circuit, since the reader load could be represented as the resistance losses of capacitor C2. Therefore, the quality factor of capacitor C2 can be expressed in terms of its losses resistance, as indicated in Figure 14. The equivalence between series and parallel circuit is granted if the real and imaginary parts are equal, thus:
Capacitive equivalent circuits.
That approximation allows the conversion of tag load Rp into Rs, as given by (44). The approximation is possible since the capacitor presents low losses at the frequency range. Thus, tag load provides the larger contribution in the energy dissipation in the magnetic coupling between reader and tag.
Observe also that the equivalent capacitor given by (45) is frequency dependent that implies in another source of variation in the resonance frequency at the tag. Based on that premise, the equivalent circuit is shown in Figure 15.
Modified equivalent circuit.
The circuit of Figure 15 can be equated as:
Thus:
where M is the mutual inductance between L1 and L2.
Combining (48) and (49) results into:
It can be observed from (5) the possibility of predicting the voltage at the tag, under free space conditions. Nevertheless, in real application, the tag shall be placed inside a human being, usually in the belly area, in order to measure any biological data. Since pork tissue presents electromagnetic properties similar to human tissue, it will be used in the measurements.
It was used the test set up shown in Figure 16, where L1 =1.77 uH and L2 =5.4uH. Observe that the inductors are axially aligned. That orientation was chosen to achieve the best magnetic coupling, considering the ratio between length and diameter of the inductor. The inductors series resistances R1 =1.14Ω and R2 =2.2 Ω (at 13.56 MHz) were obtained using a network analyzer. The experimental measurements and the simulations were conducted considering a generator having a 1V and a 50 Ω internal impedance. The tag load was taken as a 1 kΩ resistor. Table 1 presents the measurement results.
Free space measurement test set up.
Measurement | Distance | |
5mm | 0.917 uH | |
10mm | 0.692uH | |
15mm | 0.532uH | |
20mm | 0.370uH | |
25mm | 0.287uH |
Mutual inductance measurements.
It was conducted a set of simulations of equations (44), (45) and (50) for the range of 12 to 16 MHz and the result is shown in Figure 17. It can be observed that the tag voltage is approximately 1V and the resonance frequency varied with the mutual impedance. Thus a variation in the resonance frequency will cause a change in the inductor series resistance. Therefore, in case of frequency deviation at the generator, the resistance losses can change and may alter the measurement data. As a consequence, variable capacitors C1 and C2 were added to adjust the tag voltage level at the same operation frequency. That procedure maintain the inductor characteristics regardless any frequency variation. Table 2 shows a comparison between free space measurement and simulation data.
MATLAB simulation.
Distance | Measured | Simulated | |
25mm | 769mV | 1001mV | 0.287uH |
20mm | 943mV | 1061mV | 0.370uH |
15mm | 1038mV | 1063mV | 0.532uH |
10mm | 1026mV | 1055mV | 0.692uH |
5mm | 1007mV | 1052mV | 0.917uH |
Comparison between free space measurement and simulation data.
As it can be observed, there is an error between the measurement and the simulation data, as it is shown in Table 3. Note that the error is smaller than 4.3% for distances smaller than 15mm. The error becomes larger for distance over 15mm, since there is magnetic field scattering due to coil imperfections. The connection cables between generator and reader may cause a magnetic field distribution, thus increasing the error.
Distance | Error |
5mm | -4.3% |
10mm | -2.75% |
15mm | -2.34% |
20mm | -11.12% |
25mm | -23.17% |
Error between measurement and simulation data for free space.
Once the tag voltage for free space is known, it can be compared to implanted conditions, where there is tissue between reader and tag. Figure 18 shows the set up used for the measurements, and Table 4 provides the tag voltage comparison between free space and pork tissue conditions. Since pork tissue presents electromagnetic properties similar to human tissue, it will be used in the measurements.
Distance | Free Space | Pork Tissue |
10mm | 1932mV | 1869mV |
15mm | 1869mV | 1787mV |
20mm | 1671mV | 1549mV |
25mm | 1247mV | 1202mV |
Comparison between free space and pork tissue data.
The generator voltage was raised to approximately 1.94V in order to assure that low voltage measurements are not spoiled by noise. The pork tissue thickness is approximately 10mm. As it can be directly observed form Table 4, the free space data is different form the pork tissue data. The small difference suggests that at 13.56MHz the pork tissue causes s variation in the magnetic permeability as compared to free space. The error between free space and pork tissue data is presented in Table 5. The 5mm measurement was not conducted due to the pork tissue thickness The first measurement, 10mm, was conducted with the reader in direct contact with the pork tissue.
Test set up using pork tissue.
Distance | Error |
10mm | -3.26% |
15mm | -4.39% |
20mm | -7.30% |
25mm | -3.61% |
Error between free space and pork tissue data.
The classic circuit theory can be used to obtain the tag voltage from the mutual inductance between reader and tag in a RFID system. Therefore, based on the estimate of the mutual inductance between reader and tag, it is possible to estimate voltage at the tag. Nevertheless the main distress is the variation on the resonance frequency due to the mutual inductance, and ultimately, the coupling factor.
Two approximations must be conducted to estimate the tag voltage. The first one is due to the magnetic scattering between reader and tag inductors that becomes more relevant as the distance between them increases. The second approximation is due to the tissue that alters the magnetic permeability and consequently reduces the tag voltage. Thus, by considering the simulation errors and the errors due to the tissue, it is possible to estimate the voltage at the tag. Table 6 presents the compiled errors.
Distance | Error |
10mm | -5.92% |
15mm | -6.66% |
20mm | -17.60% |
25mm | -26.90% |
Total errors between simulated and measured data.
Therefore, by taking into account both approximations it is possible to estimate the voltage drop at the tag and consequently, the power reduction. Once the power reduction is known, it can be taken into account during the tag circuit design. Consequently, the use of classic theory of magnetically coupled circuits is a simple way to estimate the voltage in implanted devices. Nevertheless additional studies regarding the resonance frequency variation is still required.
The present day busy and techno savvy life of the people and more with youngsters are provoking people to think of utilizing the brain power more than the other body parts as used in the so to say busy and intelligent life style. Technology is being used by all much more than ever before. It has already been tried with Human Computer Interaction (HCI) applications successfully [1]. The present day presentation, reading, writing and speaking are expected to be done in smart system, where multiple works can be done simultaneously using finger tips, gesture, posture, vision and speech or any other system, which is user friendly and controlled by the brain signals a bit directly giving emphasis to cognition management before execution. Or we can say that in IUI the net impact is the influence of Artificial Intelligence (AI) on Human Computer Interaction on the activities of HCI. Instead of the traditional interfaces one can use Intelligent Interfaces to interact with the day to day life activities starting from study table to any type of action (Figure 1).
Interdependency of interactions with techniques, machines and interfaces [
It is assumed and accepted that Human Computer Interaction has been observed as implicit interaction with respect to traditional communication. Few years back we are habituated to use traditional communication system like telephone, letter writing, personal meeting etc. Later with the development of computers we are in a situation of using the computer, mailing service and mobile phones etc. But as we are entering more towards automation the communication system that we are going to use in near future is totally advanced with respect to the Human Computer Interaction system (HCI) [2, 3, 4]. Automation along with the Artificial Intelligence has influenced our life so much that we are bound to move with the fast moving system in the world (Figure 2).
The concept diagram for the need and basics of intelligent user interface [
It is observed that the availability of automation and speedy life style has forced us to opt for automation. Presently every country is having supportive infrastructure to manage this type of automation. Different type of Interfaces is the basic need to meet the challenges of the smart world through which we are passing through presently. Among the smart Intelligent Interfaces different type of intelligent interfaces may include devices like signal based, gesture based, and speech based but not limited to these types. In a specific way it may be mentioned that IUI uses the following platforms to be effective and useful [5] (Figure 3).
Components of intelligent user interfaces [
The challenges to this device development and utilization are many fold. Among those some very important issues are
Illiteracy
English Illiteracy
Unavailability of Network
Unavailability of Suitable Devices
Language compatibility
and many more human centric issues, which need attention to provide solutions.
Intelligent user interfaces deal with interactive human like interaction to solve any problem. Most effectively without typing can a person deal with the computer and its usage is the challenge of the day.
Explosive materials availability and use in different sectors like national, international and global information extraction and exchange platform. Available present facilities or devices are not enough for futuristic use.
To provide solutions to such situations development of Intelligent User Interfaces are a must. Such Interfaces may include technological concepts like
Image Processing (Gesture)
Speech Processing (Command mode)
Sensors like light, sound, temperature, tactile and pressure sensors to make the Intelligent Interfaces interactive with gesture and posture without writing code or operating with human interventions (tactile sensor for touch sensitive interactions etc.)
Internet of Things (IOT) compatible devices etc.
These factors have motivated the users of different levels to utilize the Multimedia facilities towards the interface development to the challenges due to the complexities in connectivity like telephone network, wireless and satellite communications. Multimedia solutions are a part of the solutions to such problems. Such efforts are supported by the improved microprocessor and storage facilities available now. Such device development may be included in all applications through different WIMP (windows, icons, menus, and pointing) interfaces [6]. It was realized that the real world problem can be better solved by providing Intelligent Interfaces.
Lot of research activities are being carried out and are also presently getting improved due to the dynamic growth of requirements both by human being and machine providing services to mankind in the field of Human Computer Interaction. Techniques embedded with Artificial Intelligence and Machine Learning in the physical devices leads towards the design and development of Intelligent User Interfaces. The Interfaces should be adaptive and adaptable to be intelligent [6, 7].
With respect to implicit Human Computer Interface development in anticipation to the behavior of the user the context expected to be developed the interfaces are to be designed. Most importantly the sensor output based interactions and context dependency can be solved for the purpose using Machine Learning Techniques as well as rule based systems. Thus the sensor based output interpretation and its generic user based modelling to use at large and in particular are challenges for the Intelligent User Interface users as their requirement is dynamic and sources of knowledge in streaming a type of Big Data. It also takes care of emotions of the user and acts accordingly. Context based factors are user based factors like and depends on Physical Environment like location, infrastructure and Human factors like user, social environment. Some of the Interfaces developed by the author in Indian Languages may be discussed here.
Any situation which deals with user and its action and provides output in the form of action which is proactive and functions with prior and appropriate anticipation of the result towards the user need is like motion detector in door opener and locker, beginning of an escalator or conveyor belt, smart communication devices like smart mobiles or tablets which changes it operational conveniences while moving in railway stations, shopping malls long corridors which enables user to pass through being unmindful towards the path. Making on and off of the rooms and room air-conditioners and adjusting the temperature inside the room may be a conference room even is the required setups which needs intelligence interfaces.
It is quite important to find the relationships between the intelligence in a system and the user interaction, which is called the intelligent processing found in the user interface(s) of the system. Such a system should meet the conditions namely effective, natural, or otherwise appropriate interaction of users with the system [8]. Here mainly the system helps the user with pseudo human communication system like speech, gesture or any other form of communication like human beings. Here the interfaces function like an intelligent human being to assist the user to function as per his/her will. This supports the interaction system like human to human interaction with the specially developed system with intelligent interfaces.
Further to say that implicit human computer interaction is an important aspect towards the development of Intelligent Interfaces. The most complex factor which is cognition oriented is computing the human behavior like recognition, interpretation, modelling processing and synthesis of human affects the emotions. Recognized human computer interaction can help in developing effective Intelligent Interfaces. Emotion is of great importance while developing Intelligent User Interfaces as use of those purely depends on the emotions of the users.
Different types of emotions are described by different scientists in due course. Some of those are mentioned below for reference.
Under discrete model Ekman’s Model is well established in treating emotions in terms of discrete and different construct for the analysis of emotion. As per Paul Ekman Model there are seven basic emotions namely Happiness, Sadness, Fear, Disgust, Anger, Contempt and Surprise.
Under Dimensional Model emotions are described mostly through Russel’s Model and Plutchik’s Model.
Russel’s Model by James A Russell describes in two dimensional circular space like arousal and valence with as much as twenty-eight types of emotion having five major classes namely Happy, Relaxed, Sad, Angry and Normal.
Plutchik’s Model by Robert Plutchik [9] has eight standard models described as an extension of Russel’s Model where the eight emotions are anger, anticipation, joy, trust, fear, surprise, sadness and disgust (Figures 4 and 5).
Russel’s model of emotions, where 28 types of emotions are displayed [
Pultchik’s wheel of emotion showing major eight types of emotion observed [
Pultchik’s Wheel of Emotion is described as the wheel of emotion classification and have eight types of resultant emotions. To identify the exact emotion of the user to work accordingly is a sensitive issue.
It is quite important to find the relationships between the intelligence in a system and the user interaction, which is called the intelligent processing is found in the user interface(s) of the system. Such a system should meet the conditions namely effective, natural, or otherwise appropriate interaction of users with the system. Sine here mainly the system helps with human like communication system like speech, gesture or any other form of communication like human beings. Here the interfaces function like an intelligent human being to assist the user to function as per his/her will. This supports the interaction system like human to human interaction with the specially developed system with intelligent interfaces.
Intelligent user Interface systems should have mainly the following criteria like: recommender systems, products, documents, or any other consequential follow-up action. This involves intelligent technology to support information retrieval, appropriate learning environments with learning assistance interface agent with capacity to monitor a situation intelligently assessing the situation and acts for the user of the system using the knowledgebase created with the domain. The main factor of Intelligent Interfaces is the cognition and the agent has to act and react as per the emotions embedded into the need of the user.
The Intelligent Agent that functions behind the IUI has at least the following characteristics [5].
Input analysis
Output functioning
Agent based interaction
Multimodal output presentation interfaces
Well defined model based interfaces
Image based Interaction Interface
Speech based interaction interface
Text analyzing capacity
Heuristic Searching capacity
Intelligent output layout designing capacity
Handling the challenges due to multilingual speech instructions
The performance of an intelligent component may be sensible to failure leading to inappropriate interpretations of commands leading to action and appropriate reaction as Intelligent processing is often relatively difficult for users to predict, understand, and control a demanding situation online. If the demand is bit more elongated depending on relatively extensive information about the users, the intelligent systems may raise certain types of privacy and security risks as private data may not be easy due to security point.
Major challenge to such a situation is evaluating the order of performance of the algorithms used in design and execution of the Intelligent Interfaces. This involves Smart speech processing for talking to the smart human user, Image processing for viewing the activities of the smart human user and Natural Language Processing for understanding the language of a human who is not aware of the language the system is dealing with. As such system will be immediate use of the elderly people and small children. Besides these the factor that influences more is the environment which, controls the functioning of the Intelligent User Interfaces mostly as it changes its features like facilities with respect to user interaction accordingly.
To have Smart Eyes, Ears and Skin (touch) for the IUI are the foremost devices to be developed to enable it to act as the IUI in true sense. Besides the sensor based applications are a basic need for such a system. Presently sensors are operational through Internet. Most of the activities can be controlled by such devices called Internet of Things or IOT. These are the smallest unit in IUI for the largest objective satisfaction. The most important point here to use such devices in IUI is the Security in using IOT as it is internet controlled Cyber intervention are very much expected [11].
User Interfaces are developed using mostly languages like XML, UML and UIML etc.as it deals with different types of users and their requirements in open mode [11].
There are models which are used towards the development of these Intelligent Interfaces.
First one is the Domain Model, which deals with data storage aspects as per the need of the users to complete an assigned work.
Next is the Task Model which is designed to represent the tasks the users may be allowed to perform taking into consideration the time factor of execution. It is mostly ConcurTaskTRees notation based model.
Vanderdonckt and Bodart described the Abstract User Interface Model which includes the user interface expressed in terms of abstract interaction objects [6]. This model is platform independent like Desktop, Laptop, PDA and Smart Phones and modality independent like voice or image input and output.
Then is the Concrete User Interface Model which represents the user interface, which is a composition concrete interaction objects [6]. Here the final user interface is developed to interact with the specified users of the system to support the Human Computer Interaction.
Finally, the Context Model deals with the whole of the context those are to be stored towards the operation and management of the system. It is a combination of the user model, a platform model and an environment model.
This is a combination of Artificial Algorithms to Human Centered Computing or in short Human Centered Artificial Intelligence or HCAI.
Success of IUI depends on many factors like Misinterpretation of Cognitive Interaction leading to incorrect understanding by user, erroneous interpretation of instructions by the devices leading to controlling of the system by the user. Depending upon the length of the query demanded by the user the issue of security and privacy will be compromised leading to complex situation [12, 13].
The important factor leading the functioning of the IUI is the dynamism of the user demand depending upon the environment to which the system is exposed to at that time. The solution may be strong algorithm development according to the dynamism of the situation around the user.
One of the most used IUI will be the Tabletop Devices as Intelligent User Interface [14, 15]:
The Tabletop design is an example of IUI to be used in different fields like Education system and Ambient Assistance system as an Augmented Reality facility to cater the needs of the present day situation, when the students aa well as the elderly people are exposed to distance mode of learning and functioning with multimodal facilities around them. This will enhance the growth of interactive tabletop device development activities to cater to the need of academicians and industry people. This has happened due to the increase of interactive systems with digital support brining digital power to table surfaces to support human activities intelligently. To mention the core aspects of interactive tabletop computing devices it may be mentioned that (i) Hardware development of horizontal touch surfaces, (ii) Multimodal Interfacing facilities as per the need like touch, speech, voice and gesture facilities meeting the novel touch and modes of use by the user. A snap shot of the Samsung SUR40 Intelligent User Interface is given below [15] (Figure 6).
Samsung SUR40 tabletop intelligent user Interface [
One can think of designing an interface intelligent enough to cater the needs of the user. But the category of the users is a big challenge towards the development of the devices. Intelligent User Interface design will mostly depend on the features of Speech Processing, Image Processing and Natural Language Processing Tools.
A screen shot of a Speech Processing Tool developed for Odia Language is given below. This based on the concatenative method of phones used in Odia Language. It helps a user to listen to any text written in Odia language being converted to speech form. It uses the Artificial Intelligence based techniques to cater to the need of the user. This technique has already been tested for many Indian Languages including Indian English. Here the phones, which is the smallest sound unit used in any language are identified and depending upon the pronunciation rules those are concatenated to form a word, thus a sentence. A text may be directly written or read from a file already available like office orders. It reads it out for the user [16, 17, 18, 19] (Figure 7).
Odia language phone based text-to-speech system [
It is observed that many documents are in scanned document form which is not possible to link it to any Text-To-Speech System. Here is a successful attempt to read the content for the needy persons like illiterate and visually challenged [20, 21, 22, 23, 24, 25].
A snap shot of the intelligent user interface for physically challenged is shown below, which works on mouse click as well as speech commands [26, 27, 28, 29, 30] (Figure 8).
Odia language optical character recognition system which performs on speech commands and reads out the output the OCRed text to the listen [
For all such type of Intelligent Interface Development, Natural Language matters as the user may not be English Language Always. The problem to make it more effective towards global use the language factor consisting of Image and Speech are to be handled where the natural process of writing, speaking matters. Thus the factors to be considered are to be considered in connection with the Natural Language Processing aspect.
Here the author has used several user interfaces which are able to manage intelligently the commands or uses expressed in terms of speech or written form. To solve it and exactly interpret to convert it to command for the device different aspects of NLP like Machine Translation, Name Entity Recognition, Grammar restriction free command etc. free like natural speech in command mode are dealt with. Some of the works are mentioned in the papers [31, 32, 33, 34].
Even the gesture is most important as any user will prefer to use gesture to express the mind as at cognition level the brain synthesizes the command and expresses it different form like Speech or Text.
While entering to Industrial Revolution 4.0, which is a combination of Automation and Internet, device development is a challenge. More of Automated devices are to be developed, which will use Sensor based commands and will execute it as per the need of the users. Thus IOT based device development is inevitable.
Such work involving the Sensor based includes but not limited to Multiple Sensor based Table Tops. It may be multimodal, multiuser and affordance of the table for multimodal operations accommodating the objects on the Tabletop. Here not only the Tabletops support hand and gesture mode operation but also tangible interaction and often needed visualization [35, 36].
Table Top applications have a massive application in viewing dominated working platform like photo or videos, brain teasing activities like game or competition besides normal computational work to advanced visualization of Dataset dynamically.
The important points for research to be handled for such devices are
Computer Supported Cooperative Work (CSCW), which is the computer-mediated group collaboration and social interactions
Human Computer Interaction (HCI) beyond the desktop setup to individual user actions and reactions.
Ubiquitous Computing (UbiComp) to accommodate variety of input data and output models.
Tangible User Interfaces (TEI) which involves interaction with physical objects on a tabletop and to ovoid those dynamically.
Considering the simple Table top application as one of the simple examples of IUI we observe that the following few parameters are to be taken into consideration while developing the devices. To achieve it mostly we have to go for IOT based services.
The other point to be handled by the scientists are
The Touch Panel, Sensor grid (electrodes) covered by front layer, which enables accurate detection of multi-touch, high positional accuracy.
The other point is Surface/projected capacitive solutions only work with finger or special stylus and not suited for large panels with slower transmission of electrical current. These items are mostly used in Smart Mobiles, which is under metamorphism as per the requirements and demands of the users.
Low-cost manufacturing, Low power consumption compared to other approaches.
Inputs requires pressure on the outer layer.
Reactive to the stylus or when user wearing gloves.
Reduced display quality due to the additional complex layers for execute the functioning details.
Compatible to Mobile Phones, PDAs, Digital Cameras or any other devices under development and use plan.
These are the future challenges which need quick solutions to meet the busy, preoccupied and smart users for their needs. Hope the trend of current research leading to such requirements can provide solutions to these problems as Intelligent User Interfaces are unavoidable in the future generation technology users. It is as dynamic as the need of the end user and the development is a challenge to the developers.
These are leading to the aspects of Augmented Reality and Virtual Reality, which is the Next Generation Computing.
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MS pathogenesis is not clear. Destruction of myelin by inflammation caused by autoimmune reactions has been proposed. Interestingly, healthy humans usually do not develop abzymes (Abzs). It was shown that DNase and MBP-hydrolyzing Abzs are easily detectable at the beginning of autoimmune diseases (ADs) including MS, when concentrations of antibodies to autoantigens are not yet significantly increased and correspond to levels in healthy donors. In addition, the relative enzymatic activity of antibodies from cerebrospinal fluid (CSF) is ~50-fold higher than that from the sera of the same MS patients. Experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice, a model mimicking relevant aspects of human MS was used. During development of spontaneous and MOG35-55-induced EAE in C57BL/6 mice, a specific reorganization of the immune system of mice was observed. 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Rakotonirina",authors:[{id:"31580",title:"Prof.",name:"Elisabeth",middleName:null,surname:"Ngo Bum",slug:"elisabeth-ngo-bum",fullName:"Elisabeth Ngo Bum"},{id:"46671",title:"Dr.",name:"Germain",middleName:"Sotoing",surname:"Taïwe",slug:"germain-taiwe",fullName:"Germain Taïwe"},{id:"46672",title:"MSc.",name:"Fleur",middleName:null,surname:"Moto",slug:"fleur-moto",fullName:"Fleur Moto"},{id:"46673",title:"Prof.",name:"Gwladys",middleName:"Temkou",surname:"Ngoupaye",slug:"gwladys-ngoupaye",fullName:"Gwladys Ngoupaye"},{id:"46674",title:"MSc.",name:"Espoir",middleName:null,surname:"Ayissi",slug:"espoir-ayissi",fullName:"Espoir Ayissi"},{id:"46675",title:"MSc.",name:"Christian",middleName:null,surname:"Dong",slug:"christian-dong",fullName:"Christian Dong"},{id:"46676",title:"MSc.",name:"Frédéric",middleName:null,surname:"Maidawa",slug:"frederic-maidawa",fullName:"Frédéric Maidawa"},{id:"46677",title:"MSc.",name:"Gildas",middleName:null,surname:"Djafsia",slug:"gildas-djafsia",fullName:"Gildas Djafsia"},{id:"46678",title:"MSc.",name:"Leopold",middleName:null,surname:"Nanga",slug:"leopold-nanga",fullName:"Leopold Nanga"},{id:"46679",title:"MSc.",name:"Saleh",middleName:null,surname:"Soudi",slug:"saleh-soudi",fullName:"Saleh Soudi"},{id:"46680",title:"Dr.",name:"Alice",middleName:null,surname:"Rakotonirina",slug:"alice-rakotonirina",fullName:"Alice Rakotonirina"},{id:"46681",title:"Dr.",name:"Silvère",middleName:null,surname:"Rakotonirina",slug:"silvere-rakotonirina",fullName:"Silvère Rakotonirina"}]},{id:"44560",doi:"10.5772/54744",title:"The Role of Epigenetics in Neurodegenerative Diseases",slug:"the-role-of-epigenetics-in-neurodegenerative-diseases",totalDownloads:4012,totalCrossrefCites:10,totalDimensionsCites:18,abstract:null,book:{id:"3278",slug:"neurodegenerative-diseases",title:"Neurodegenerative Diseases",fullTitle:"Neurodegenerative Diseases"},signatures:"Luca Lovrečić, Aleš Maver, Maja Zadel and Borut Peterlin",authors:[{id:"75615",title:"Dr.",name:"Luca",middleName:null,surname:"Lovrecic",slug:"luca-lovrecic",fullName:"Luca Lovrecic"}]}],mostDownloadedChaptersLast30Days:[{id:"44555",title:"Pharmacological Treatment of Acute Ischemic Stroke",slug:"pharmacological-treatment-of-acute-ischemic-stroke",totalDownloads:3674,totalCrossrefCites:7,totalDimensionsCites:9,abstract:null,book:{id:"3278",slug:"neurodegenerative-diseases",title:"Neurodegenerative Diseases",fullTitle:"Neurodegenerative Diseases"},signatures:"Humberto Mestre, Yael Cohen-Minian, Daniel Zajarias-Fainsod and\nAntonio Ibarra",authors:[{id:"72488",title:"Dr.",name:"José Juan Antonio",middleName:null,surname:"Ibarra Arias",slug:"jose-juan-antonio-ibarra-arias",fullName:"José Juan Antonio Ibarra Arias"},{id:"120571",title:"Mr.",name:"Humberto",middleName:null,surname:"Mestre",slug:"humberto-mestre",fullName:"Humberto Mestre"},{id:"165904",title:"Dr.",name:"Daniel",middleName:null,surname:"Zajarias-Fainsod",slug:"daniel-zajarias-fainsod",fullName:"Daniel Zajarias-Fainsod"},{id:"165905",title:"Mrs.",name:"Yael",middleName:null,surname:"Cohen-Minian",slug:"yael-cohen-minian",fullName:"Yael Cohen-Minian"}]},{id:"60608",title:"Mucuna and Parkinson’s Disease: Treatment with Natural Levodopa",slug:"mucuna-and-parkinson-s-disease-treatment-with-natural-levodopa",totalDownloads:4670,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Mucuna pruriens is a tropical bean containing large amounts of levodopa and is the most important natural remedy for Parkinson’s disease. Famous neurologists have patented methods of extraction for its advantages over the synthetic forms, Sinemet and Madopar. This natural levodopa is less toxic and has a faster and more lasting effect and can delay the need for pharmaceuticals and combination therapies. Currently, there are many patients with Parkinson’s disease who take Mucuna and spontaneously reduce the dose of conventional drugs and do so behind their doctors’ backs. Mucuna should always be taken under medical supervision.",book:{id:"6406",slug:"parkinson-s-disease-understanding-pathophysiology-and-developing-therapeutic-strategies",title:"Parkinson's Disease",fullTitle:"Parkinson's Disease - Understanding Pathophysiology and Developing Therapeutic Strategies"},signatures:"Rafael González Maldonado",authors:[{id:"214658",title:"Dr.",name:"Rafael",middleName:null,surname:"Gonzalez-Maldonado",slug:"rafael-gonzalez-maldonado",fullName:"Rafael Gonzalez-Maldonado"}]},{id:"19700",title:"Physiotherapy for Children with Cerebral Palsy",slug:"physiotherapy-for-children-with-cerebral-palsy",totalDownloads:21776,totalCrossrefCites:1,totalDimensionsCites:3,abstract:null,book:{id:"630",slug:"epilepsy-in-children-clinical-and-social-aspects",title:"Epilepsy in Children",fullTitle:"Epilepsy in Children - Clinical and Social Aspects"},signatures:"Mintaze Kerem Günel",authors:[{id:"38412",title:"Prof.",name:"Mintaze",middleName:null,surname:"Kerem Günel",slug:"mintaze-kerem-gunel",fullName:"Mintaze Kerem Günel"}]},{id:"51151",title:"Association Between Multiple Sclerosis Risk and Human Immunodeficiency Virus Infection: Insights and Challenges",slug:"association-between-multiple-sclerosis-risk-and-human-immunodeficiency-virus-infection-insights-and-",totalDownloads:2060,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Multiple sclerosis (MS) is a convoluted autoimmune and inflammatory disease of the central nervous system (CNS) in which the protective myelin sheath is eroded and the underlying nerve fibers are damaged. There is no conclusive knowledge on the role played by different etiological factors in its development, and studies have shown that it primarily results due to complex interactions between the genetic, geographic and infectious components. Among the risk factors reported to have a possible role in MS development, retroviruses also appear to influence it. Studies suggest human immunodeficiency virus (HIV) infection to be inversely related to MS risk, but to date, the association between the two remains enigmatic. This protective inverse association has become an area of active research and the most plausible explanations for this may be immune suppression and/or antiretroviral medications. The purpose of writing this chapter is to provide background information on the unfathomable relationship between HIV infection and the risk of developing MS while at the same time providing description of the insights garnered from recent studies. While highlighting the application of ART (antiretroviral therapy) as budding future alternative for MS management, this chapter provides momentum for further studies.",book:{id:"5156",slug:"trending-topics-in-multiple-sclerosis",title:"Trending Topics in Multiple Sclerosis",fullTitle:"Trending Topics in Multiple Sclerosis"},signatures:"Ehtishamul Haq, Insha Zahoor and Mushfiquddin Khan",authors:[{id:"181077",title:"Dr.",name:"Ehtishamul",middleName:null,surname:"Haq",slug:"ehtishamul-haq",fullName:"Ehtishamul Haq"},{id:"185233",title:"Dr.",name:"Insha",middleName:null,surname:"Zahoor",slug:"insha-zahoor",fullName:"Insha Zahoor"},{id:"185234",title:"Dr.",name:"Mushfiquddin",middleName:null,surname:"Khan",slug:"mushfiquddin-khan",fullName:"Mushfiquddin Khan"}]},{id:"63824",title:"Plasmapheresis in Treatment of Myasthenia Gravis",slug:"plasmapheresis-in-treatment-of-myasthenia-gravis",totalDownloads:1353,totalCrossrefCites:1,totalDimensionsCites:1,abstract:"Treatment of myasthenia gravis is still a rather difficult task, since there is no single tactic to use different drugs (corticosteroids, rituximab, immunoglobulins), especially since it is associated with a number of side effects. They are not able to remove the accumulating autoantibodies and immune complexes, the large size of which does not allow them to be excreted by the kidneys as well. Special problems of treatment arise when myasthenic crises develop associated with respiratory failure requiring artificial lungs ventilation. Plasmapheresis can help to solve this for it is possible to remove antibodies and other pathological metabolites. In addition, regular plasmapheresis is able not only to prevent exacerbations but also to reduce doses of the maintenance therapy with less risk of their side effects, which is confirmed by our own experience.",book:{id:"7160",slug:"selected-topics-in-myasthenia-gravis",title:"Selected Topics in Myasthenia Gravis",fullTitle:"Selected Topics in Myasthenia Gravis"},signatures:"Valerii Voinov",authors:null}],onlineFirstChaptersFilter:{topicId:"1056",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81721",title:"Atrial Fibrillation and Stroke",slug:"atrial-fibrillation-and-stroke",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.104619",abstract:"Atrial fibrillation (AF) represents a major cause of morbidity and mortality in adults, especially for its strong association with thromboembolism and stroke. In this chapter, we aim to provide an overview on this cardiac arrhythmia, addressing several important questions. Particularly, we faced the possible mechanisms leading to an increased risk of embolism in AF, emphasizing how Virchow’s triad for thrombogenesis is unable to fully explain this risk. Disentangling the risk of stroke caused by AF and by other associated vascular conditions is extremely challenging, and risk stratification of patients with AF into those at high and low risk of thromboembolism has become a crucial determinant of optimal antithrombotic prophylaxis. Moreover, we discuss the typical clinical and radiological characteristics of cardioembolic strokes, addressing acute, time-dependent reperfusional therapies in case of ischemic stroke. The role of anticoagulation in AF is also fully analyzed; the benefit of oral anticoagulation generally outweighs the risk of bleeding in AF patients, and a variety of scoring systems have been developed to improve clinical decision-making when initiating anticoagulation. With their predictable pharmacokinetic profiles, wide therapeutic windows, fewer drug–drug and drug-food interactions, and the non-vitamin K antagonist (VKA) oral anticoagulants (NOACs) have changed the landscape of thromboprophylaxis for AF patients, offering the opportunity to use effective anticoagulants without the need for intensive therapeutic drug monitoring.",book:{id:"10782",title:"Cerebrovascular Diseases - Elucidating Key Principles",coverURL:"https://cdn.intechopen.com/books/images_new/10782.jpg"},signatures:"Francesca Spagnolo, Vincenza Pinto and Augusto Maria Rini"},{id:"81639",title:"Atrial Cardiopathy and Cryptogenic Stroke",slug:"atrial-cardiopathy-and-cryptogenic-stroke",totalDownloads:24,totalDimensionsCites:0,doi:"10.5772/intechopen.103736",abstract:"Cryptogenic stroke (CS) is defined as the presence of cerebral infarcts, the cause which has not been identified despite an appropriate diagnostic evaluation, and it accounts for approximately 30–40% of all ischemic strokes. There is a certain subgroup of CS with embolic characteristics on neuroimaging studies and no evidence of atrial fibrillation alternative or any alternative cause. Recent data suggest that disorders of the atrium, even without atrial fibrillation, could increase thromboembolic risk. The pathological atrial substrate, or atrial cardiopathy (AC), may be an important and underrecognized cause of cryptogenic strokes. This chapter will review the information on the rationale and data behind the concept of atrial cardiopathy, its pathophysiology, proposed biomarkers of atrial cardiopathy, and therapeutic implications.",book:{id:"10782",title:"Cerebrovascular Diseases - Elucidating Key Principles",coverURL:"https://cdn.intechopen.com/books/images_new/10782.jpg"},signatures:"Marianela López Armaretti, Natalia Romina Balian and María Cristina Zurrú"},{id:"81011",title:"Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications",slug:"amino-acids-as-neurotransmitters-the-balance-between-excitation-and-inhibition-as-a-background-for-f",totalDownloads:33,totalDimensionsCites:0,doi:"10.5772/intechopen.103760",abstract:"For more than 30 years, amino acids have been well-known (and essential) participants in neurotransmission. They act as both neuromediators and metabolites in nervous tissue. Glycine and glutamic acid (glutamate) are prominent examples. These amino acids are agonists of inhibitory and excitatory membrane receptors, respectively. Moreover, they play essential roles in metabolic pathways and energy transformation in neurons and astrocytes. Despite their obvious effects on the brain, their potential role in therapeutic methods remains uncertain in clinical practice. In the current chapter, a comparison of the crosstalk between these two systems, which are responsible for excitation and inhibition in neurons, is presented. The interactions are discussed at the metabolic, receptor, and transport levels. Reaction-diffusion and a convectional flow into the interstitial fluid create a balanced distribution of glycine and glutamate. Indeed, the neurons’ final physiological state is a result of a balance between the excitatory and inhibitory influences. However, changes to the glycine and/or glutamate pools under pathological conditions can alter the state of nervous tissue. Thus, new therapies for various diseases may be developed on the basis of amino acid medication.",book:{id:"10890",title:"COVID-19, Neuroimmunology and Neural Function",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Yaroslav R. Nartsissov"},{id:"80821",title:"Neuroimmunology and Neurological Manifestations of COVID-19",slug:"neuroimmunology-and-neurological-manifestations-of-covid-19",totalDownloads:59,totalDimensionsCites:0,doi:"10.5772/intechopen.103026",abstract:"Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study.",book:{id:"10890",title:"COVID-19, Neuroimmunology and Neural Function",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Robert Weissert"},{id:"80005",title:"Infarct Stroke and Blood Glucose Associated with Food Consumption in Indonesia",slug:"infarct-stroke-and-blood-glucose-associated-with-food-consumption-in-indonesia",totalDownloads:65,totalDimensionsCites:0,doi:"10.5772/intechopen.101548",abstract:"Stroke is the primary cause of death in adults. It is predicted that the death caused by stroke will increase twice in the next 30 years. In Indonesia, stroke is one of the diseases of the circulatory system, which has been taking the first place of causing death since 2007. Indonesia has rice as the main type of daily food consumed, which has higher glycemic index than other sources. This study aims to find the risk of blood glucose level that determines the incidence of infarct stroke. There were 164 patients enrolled in this study, 82 patients in each stroke and not stroke group. The blood examination is using the enzymatic method, which is the hexokinase method. The results of research revealed that indicators of high blood glucose level were found in infract stroke incidence, including casual blood glucose, fasting blood glucose, 2-h postprandial blood glucose, and glycated hemoglobin. These four indicators were found in a higher level in the infarct stroke than the non-stroke group. Other epidemiological studies have shown that diabetes is a risk factor for stroke. Therefore, education about food selection should be a priority in the effort to prevent infarct stroke and diabetes mellitus in Indonesia.",book:{id:"10782",title:"Cerebrovascular Diseases - Elucidating Key Principles",coverURL:"https://cdn.intechopen.com/books/images_new/10782.jpg"},signatures:"Santi Martini, Hermina Novida and Kuntoro"},{id:"80391",title:"COVID-19 and Seizures",slug:"covid-19-and-seizures",totalDownloads:59,totalDimensionsCites:0,doi:"10.5772/intechopen.102540",abstract:"The past two years were deeply marked by the emergence of a global pandemic caused by the worldwide spread of the virus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection. The plethora of repercussions on the health of those affected is extensive, ranging from asymptomatic individuals, mild flu-like disease, and severe respiratory failure, eventually leading to death. Despite this predilection for the respiratory system, the virus is responsible for multisystemic manifestations and soon became clear that neurological involvement was a frequent issue of coronavirus disease 2019 (COVID-19). Much have been pointed out about the neurotropic nature of the virus, the ways by which it invades and targets specific structures of the central nervous system, and the physiopathology behind the neurologic manifestations associated with it (namely encephalomyelitis, Guillain-Barré syndrome, lacunar infarcts, and vascular dysfunction, just to list a few). This chapter aims to raise light about the association between COVID-19 and the mechanisms of acute symptomatic seizures, through neurotropism and neuroinvasion features of SARS-CoV-2, and to review the variety of clinical presentations reported so far.",book:{id:"10890",title:"COVID-19, Neuroimmunology and Neural Function",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Rafael Jesus, Carolina Azoia, Paulo Coelho and Pedro Guimarães"}],onlineFirstChaptersTotal:16},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:333,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:144,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:113,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:23,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/23.jpg",latestPublicationDate:"August 17th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"280770",title:"Dr.",name:"Katherine K.M.",middleName:null,surname:"Stavropoulos",slug:"katherine-k.m.-stavropoulos",fullName:"Katherine K.M. Stavropoulos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRdFuQAK/Profile_Picture_2022-05-24T09:03:48.jpg",biography:"Katherine Stavropoulos received her BA in Psychology from Trinity College, in Connecticut, USA and her Ph.D. in Experimental Psychology from the University of California, San Diego. She completed her postdoctoral work at the Yale Child Study Center with Dr. James McPartland. Dr. Stavropoulos’ doctoral dissertation explored neural correlates of reward anticipation to social versus nonsocial stimuli in children with and without autism spectrum disorders (ASD). She has been a faculty member at the University of California, Riverside in the School of Education since 2016. Her research focuses on translational studies to explore the reward system in ASD, as well as how anxiety contributes to social challenges in ASD. She also investigates how behavioral interventions affect neural activity, behavior, and school performance in children with ASD. She is also involved in the diagnosis of children with ASD and is a licensed clinical psychologist in California. She is the Assistant Director of the SEARCH Center at UCR and is a faculty member in the Graduate Program in Neuroscience.",institutionString:null,institution:{name:"University of California, Riverside",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"89",title:"Education",coverUrl:"https://cdn.intechopen.com/series_topics/covers/89.jpg",isOpenForSubmission:!1,editor:{id:"260066",title:"Associate Prof.",name:"Michail",middleName:null,surname:"Kalogiannakis",slug:"michail-kalogiannakis",fullName:"Michail Kalogiannakis",profilePictureURL:"https://mts.intechopen.com/storage/users/260066/images/system/260066.jpg",biography:"Michail Kalogiannakis is an Associate Professor of the Department of Preschool Education, University of Crete, and an Associate Tutor at School of Humanities at the Hellenic Open University. He graduated from the Physics Department of the University of Crete and continued his post-graduate studies at the University Paris 7-Denis Diderot (D.E.A. in Didactic of Physics), University Paris 5-René Descartes-Sorbonne (D.E.A. in Science Education) and received his Ph.D. degree at the University Paris 5-René Descartes-Sorbonne (PhD in Science Education). His research interests include science education in early childhood, science teaching and learning, e-learning, the use of ICT in science education, games simulations, and mobile learning. He has published over 120 articles in international conferences and journals and has served on the program committees of numerous international conferences.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorTwo:{id:"422488",title:"Dr.",name:"Maria",middleName:null,surname:"Ampartzaki",slug:"maria-ampartzaki",fullName:"Maria Ampartzaki",profilePictureURL:"https://mts.intechopen.com/storage/users/422488/images/system/422488.jpg",biography:"Dr Maria Ampartzaki is an Assistant Professor in Early Childhood Education in the Department of Preschool Education at the University of Crete. Her research interests include ICT in education, science education in the early years, inquiry-based and art-based learning, teachers’ professional development, action research, and the Pedagogy of Multiliteracies, among others. 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In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. 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She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. 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He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. 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He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"117248",title:"Dr.",name:"Andrew",middleName:null,surname:"Macnab",slug:"andrew-macnab",fullName:"Andrew Macnab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"322007",title:"Dr.",name:"Maria Elizbeth",middleName:null,surname:"Alvarez-Sánchez",slug:"maria-elizbeth-alvarez-sanchez",fullName:"Maria Elizbeth Alvarez-Sánchez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",country:{name:"Mexico"}}},{id:"337443",title:"Dr.",name:"Juan",middleName:null,surname:"A. 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In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. 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He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. 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