\\n\\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\\n\\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\\n\\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\\n\\n\\n\\n\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
\n\nInitially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\nThese books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\nThis collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\nTo celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n\n\n\n\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"4648",leadTitle:null,fullTitle:"Concepts, Compounds and the Alternatives of Antibacterials",title:"Concepts, Compounds and the Alternatives of Antibacterials",subtitle:null,reviewType:"peer-reviewed",abstract:"This edition is intended to provide better understanding of antibacterial drugs and their mechanism, the role of a few metal drug complexes as antibacterials, cross-checking of a few compounds and biomaterials against drug-resistant bacterial strains as well as a few alternative approaches using medicinal plant based formulations in the control of antibiotic-resistant bacteria. The information in this book provides clues for upcoming trends in treating antibiotic resistance problems with which one can explore new approaches in the treatment of common infections with drug-resistant strains.",isbn:null,printIsbn:"978-953-51-2232-6",pdfIsbn:"978-953-51-5417-4",doi:"10.5772/59522",price:119,priceEur:129,priceUsd:155,slug:"concepts-compounds-and-the-alternatives-of-antibacterials",numberOfPages:210,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"ba284c040146d00fdd709cabc4c8cb5a",bookSignature:"Varaprasad Bobbarala",publishedDate:"December 9th 2015",coverURL:"https://cdn.intechopen.com/books/images_new/4648.jpg",numberOfDownloads:19519,numberOfWosCitations:50,numberOfCrossrefCitations:38,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:92,numberOfDimensionsCitationsByBook:3,hasAltmetrics:1,numberOfTotalCitations:180,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 20th 2014",dateEndSecondStepPublish:"November 10th 2014",dateEndThirdStepPublish:"February 14th 2015",dateEndFourthStepPublish:"May 15th 2015",dateEndFifthStepPublish:"June 14th 2015",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"90574",title:"Dr.",name:"Varaprasad",middleName:null,surname:"Bobbarala",slug:"varaprasad-bobbarala",fullName:"Varaprasad Bobbarala",profilePictureURL:"https://mts.intechopen.com/storage/users/90574/images/868_n.jpg",biography:"Dr. Varaprasad Bobbarala received his Ph.D. in Faculty of Science from Andhra University in 2008 under the direction of Professor K. Chandrasekhara Naidu and Professor G. Seshagiri Rao. Specialized in Biochemistry, Medicinal chemistry and Microbiology. He has published over 90 original research articles, reviews, book chapters, and edited three books. He is currently Editor In-Chief of International Journal of Bioassays (ISSN: 2278-778X), Associate Editor and member of the editorial boards as well as the reviewer of dozens of high-impact international periodicals. Dr. B. Varaprasad, previously served as the Chief Scientist of Research and Development (R & D) at Krisani Innovations Pvt. Ltd., before his current role as the Chief Scientist and Technical Director of Research and Development of Adhya Biosciences Pvt. Ltd., India. He is actively engaged in scientific research in the areas of Antimicrobial Resistance, Drug Discovery, Isolation of Bio-active metabolites and bio-efficacy studies.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"3",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"897",title:"Pharmaceutical Microbiology",slug:"pharmaceutical-microbiology"}],chapters:[{id:"48837",title:"Antibacterial Drugs — From Basic Concepts to Complex Therapeutic Mechanisms of Polymer Systems",doi:"10.5772/60755",slug:"antibacterial-drugs-from-basic-concepts-to-complex-therapeutic-mechanisms-of-polymer-systems",totalDownloads:3311,totalCrossrefCites:2,totalDimensionsCites:10,hasAltmetrics:0,abstract:"Infections caused by diverse bacteria represent a major problem that threats the health of humans. This stimulates the scientists to find new solutions for treating these diseases by clarifying the interactions of antibacterial compounds with the biological medium. In this context, the chapter presents some basic concepts regarding the antibacterial drugs. The synthesis routes of novel compounds and specific design techniques with polymer materials are described in correlation with the in vitro and in vivo activity of antibacterial substances. Essential data about the mechanism of action, selected in vivo efficacy and mechanisms of resistance to the most used antibacterial drugs are reviewed.",signatures:"Andreea Irina Barzic and Silvia Ioan",downloadPdfUrl:"/chapter/pdf-download/48837",previewPdfUrl:"/chapter/pdf-preview/48837",authors:[{id:"93800",title:"Dr.",name:"Silvia",surname:"Ioan",slug:"silvia-ioan",fullName:"Silvia Ioan"}],corrections:null},{id:"49219",title:"Perception and Resistance Mechanism of some Metal-drug Complexes and Their Roles as Antibacterial",doi:"10.5772/61033",slug:"perception-and-resistance-mechanism-of-some-metal-drug-complexes-and-their-roles-as-antibacterial",totalDownloads:1614,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Metal-based drugs have undergone much development and application for therapeutic and diagnostic purposes for many decades since the huge success of cisplatin and other successful metal-drug complexes in the clinical stages. Furthermore, this metal-based drug has come up with a lot of signs of resistance and side-effects in their uses. This review points to some of the resistance natures and mechanisms of previously synthesized complexes in the field of chemistry.",signatures:"Joshua A. Obaleye, Nzikahyel Simon, Olufunso O. Abosede, Mercy\nO. Bamigboye, Abiodun A. Ajibola, Uche B. Eke and Elizabeth A.\nBalogun",downloadPdfUrl:"/chapter/pdf-download/49219",previewPdfUrl:"/chapter/pdf-preview/49219",authors:[{id:"99498",title:"Prof.",name:"Joshua",surname:"Obaleye",slug:"joshua-obaleye",fullName:"Joshua Obaleye"}],corrections:null},{id:"49473",title:"Quinolone Compounds with Activity Against Multidrug- Resistant Gram-Positive Microorganisms",doi:"10.5772/60948",slug:"quinolone-compounds-with-activity-against-multidrug-resistant-gram-positive-microorganisms",totalDownloads:1731,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The emergence of resistance to antimicrobial agents is a global public health problem. Some microorganisms may develop resistance to a single antimicrobial agent (or related class of agent), while others develop resistance to several antimicrobial agents or classes. These organisms are often referred to as multidrug-resistant or MDR strains. Identification of new molecules that show activity against multidrug-resistant microorganisms and its development on a new antimicrobial drug, would be an important step in the fight against antimicrobial resistance. This paper presents experimental data regarding the synthesis of several quinolones. The novel compounds having quinolone structure were synthesized by Gould-Jacobs method. Their structure has been determined and confirmed by the following physicochemical methods: elemental analysis, IR spectral analysis, H-NMR, C-NMR, UV, thin layer chromatography. The new compounds have been evaluated for „in vitro” activity by determining minimum inhibitory concentration against a variety of bacteria Some of new quinolones, which showed a good activity, have been tested against 30 strains of methicillin resistant Staphylococcus aureus isolated in the Microbiology Laboratory of INBI Prof. “Dr. Matei Bals” during 2012 The minimum inhibitory concentration (MIC) of the isolates have been determined by agar plate Mueller Hinton (bioMerieux) dilution method using the reference strain Staphylococcus aureus ATCC 29213. The 30 strains of isolated have been also tested for susceptibility to ciprofloxacin, levofloxacin and imipenem by Etest method. Base on the “in vitro” studies, the quinolone FPQ-30 appears to be an promising compound, all strains isolates were inhibited at a concentration of 8 μg/ml.",signatures:"Pintilie Lucia",downloadPdfUrl:"/chapter/pdf-download/49473",previewPdfUrl:"/chapter/pdf-preview/49473",authors:[{id:"94504",title:"Dr.",name:"Lucia",surname:"Pintilie",slug:"lucia-pintilie",fullName:"Lucia Pintilie"}],corrections:null},{id:"49246",title:"Chitosan as a Biomaterial — Structure, Properties, and Electrospun Nanofibers",doi:"10.5772/61300",slug:"chitosan-as-a-biomaterial-structure-properties-and-electrospun-nanofibers",totalDownloads:4618,totalCrossrefCites:24,totalDimensionsCites:55,hasAltmetrics:0,abstract:"Chitosan is a polysaccharide derived from chitin; chitin is the second most abundant polysaccharide in the world, after cellulose. Chitosan is biocompatible, biodegradable and non-toxic, so that it can be usedin medicalapplications such as antimicrobial and wound healing biomaterials. It also used as chelating agent due to its ability to bind with cholesterol, fats, proteins and metal ions.",signatures:"H. M. Ibrahim and E.M.R. El- Zairy",downloadPdfUrl:"/chapter/pdf-download/49246",previewPdfUrl:"/chapter/pdf-preview/49246",authors:[{id:"90645",title:"Dr.",name:"Hassan",surname:"Ibrahim",slug:"hassan-ibrahim",fullName:"Hassan Ibrahim"},{id:"175694",title:"Dr.",name:"Enas",surname:"El- Zairy",slug:"enas-el-zairy",fullName:"Enas El- Zairy"}],corrections:null},{id:"48931",title:"Nisin",doi:"10.5772/60932",slug:"nisin",totalDownloads:2991,totalCrossrefCites:7,totalDimensionsCites:11,hasAltmetrics:0,abstract:"Antimicrobial peptides (AMPs) are small cationic peptides which protect their hosts against bacteria, protozoa, viruses, and fungi. Bacterial AMPs are called bacteriocins, and are produced by both Gram-positive and Gram-negative bacteria. Because of their high potency and specificity, bacteriocins are considered as promising antimicrobial agents for different applications, including food preservation and infection treatment; specially the ones produced by acid lactic bacteria species (Gram-positive). Nisin is the most intensively studied and used bacteriocin, it is found commercially available and its use is regulated in over 50 countries. Therefore, special attention is given to this bacteriocin.",signatures:"Angela Faustino Jozala, Letícia Celia de Lencastre Novaes and\nAdalberto Pessoa Junior",downloadPdfUrl:"/chapter/pdf-download/48931",previewPdfUrl:"/chapter/pdf-preview/48931",authors:[{id:"82505",title:"Prof.",name:"Adalberto",surname:"Pessoa Jr.",slug:"adalberto-pessoa-jr.",fullName:"Adalberto Pessoa Jr."},{id:"84924",title:"Dr.",name:"Letícia",surname:"De Lencastre Novaes",slug:"leticia-de-lencastre-novaes",fullName:"Letícia De Lencastre Novaes"},{id:"174371",title:"Dr.",name:"Angela",surname:"Jozala",slug:"angela-jozala",fullName:"Angela Jozala"}],corrections:null},{id:"48961",title:"Natural Products as Antibacterial Agents — Antibacterial Potential and Safety of Post-distillation and Waste Material from Thymus vulgaris L., Lamiaceae",doi:"10.5772/60869",slug:"natural-products-as-antibacterial-agents-antibacterial-potential-and-safety-of-post-distillation-and",totalDownloads:2633,totalCrossrefCites:3,totalDimensionsCites:13,hasAltmetrics:1,abstract:"Medicinal plants have a long tradition of use in folk and conventional medicine. In recent years numerous studies confirm various bioactivities of natural products, among them antibacterial activity. Natural antibacterial agents such are essential oils and isolated compounds now represent a notable source for pharmaceutical and food industry and are widely used in cosmetology. They meet standards of 'green consumerism' together with excellent antibacterial activity. Aromatic plants such is Thymus vulgaris L. are the major sources of essential oils. Thyme essential oil, as well as dominant compounds thymol and carvacrol are generally recognised as safe and have been registered by European Commission for use as flavouring agents in foodstuffs. However, essential oil is present in very low amount (0,8-2,6%) in thyme leaves. Thus, the majority of plant material remains unused after the isolation. Nowadays, the biological potential of various plant waste materials are in focus of numerous studies. These investigations also include the antimicrobial activity considering the fact that waste material extracts represent the valuable source of different phenolic compounds. Regarding all this, the aim of the present study was to determine antibacterial potential of chemically characterised extracts obtained from waste material remaining after the preparation of drug (stems) and isolation of thyme essential oil (deodorised leaves, postdistillation decoction) on selected bacterial strains. Also, in order to determine safety of waste extracts their cytotoxicity was investigated. All extracts were prepared with maceration using 45% or 75% ethanol (EtOH) for 24 h at room temperature (1:10 w/v). Total phenolic compounds and flavonoids were determined spectrophotometrically. Extracts were chemically characterized by HPLC/DAD analysis. Antibacerial testing was done with broth dilution method against several bacterial strains (Staphylococcus aureus, Bacillus cereus, Salmonella infantis, Escherichia coli and Campylobacter jejuni). Cytotoxicity and cytoprotection studies were performed by XTT assay. Result of HPLC analysis showed that investigated extracts, especially those obtained from deodorised leaves represent a valuable source of rosmarinic acid and luteolin 7-O-glucuronide. Antibacterial testing indicated that all waste material extracts, except the extract T2, possess similar or even stronger bacteriostatic activity than T1. No cytotoxicity nor cytoprotection were determined. In conclusion, results of this study confirmed antibacterial potential investigated thyme extracts. High concentrations of rosmarinic acid and luteolin 7-O-glucuronide, which both have numerous pharmacological activities, were determined. This indicates that thyme postdistillation waste material extracts could be used for isolation of dominant compounds or as addities in pharmaceutical and food industry.",signatures:"Neda Gavarić, Jasna Kovač, Nadine Kretschmer, Nebojša Kladar,\nSonja Smole Možina, Franz Bucar, Rudolf Bauer and Biljana Božin",downloadPdfUrl:"/chapter/pdf-download/48961",previewPdfUrl:"/chapter/pdf-preview/48961",authors:[{id:"78766",title:"Dr.",name:"Biljana",surname:"Bozin",slug:"biljana-bozin",fullName:"Biljana Bozin"},{id:"174457",title:"Dr.",name:"Neda",surname:"Gavarić",slug:"neda-gavaric",fullName:"Neda Gavarić"},{id:"174458",title:"MSc.",name:"Nebojša",surname:"Kladar",slug:"nebojsa-kladar",fullName:"Nebojša Kladar"},{id:"174460",title:"MSc.",name:"Jasna",surname:"Kovač",slug:"jasna-kovac",fullName:"Jasna Kovač"},{id:"174461",title:"Dr.",name:"Aleksandra",surname:"Mišan",slug:"aleksandra-misan",fullName:"Aleksandra Mišan"},{id:"174462",title:"Prof.",name:"Sonja",surname:"Smole Možina",slug:"sonja-smole-mozina",fullName:"Sonja Smole Možina"},{id:"174463",title:"Prof.",name:"Franz",surname:"Bucar",slug:"franz-bucar",fullName:"Franz Bucar"}],corrections:null},{id:"49693",title:"Phytopharmaceutical Studies of Selected Medicinal Plants Subjected to Abiotic Elicitation (Stress) in Industrial Area",doi:"10.5772/61891",slug:"phytopharmaceutical-studies-of-selected-medicinal-plants-subjected-to-abiotic-elicitation-stress-in-",totalDownloads:2622,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Plants are a source of large amount of drugs comprising antispasmodics, emetic, Anti-cancer, anti microbial and anticancer activities etc. A large number of the plants are claimed to possess the antibiotic properties in the traditional system and today they are extensively used by the people and the metal Components in the plants grown in polluted area seemingly increase the concentration of phytochemicals. Recent times the flora and fauna of any region is directly or indirectly exposed to the all types pollutants which may result into adverse effects rarely the metal pollutants may trigger the production of phytochemicals. The present study deals with Industrial pollution of the area selected for study, metal up take, and their effect on phytochemical, antimicrobial and anticancer activities that explore the research on five medicinal plants namely Adhatoda vasica, Eucalyptus globulus, Hyptis suaveolens, Ricinus communis and Tinospora cordifolia that thrive well and grow luxuriantly in industrial polluted area and the same five plants from natural area of Visakhapatnam District. The aim of this study is to analyze the effect of Metal elements on phytochemical productivity and antimicrobial and anticancer activity of these medicinal plants. Metal analysis is done ICP-MS (PerkinElmer Sciex Instrument, model ELAN DRC II, USA). Alkaloids, flavanoids, terpenoids and phenols screening is done in solvents Hexane, Chloroform and methanol and checked for antimicrobial activity and anti-cancer activity of Eucalyptus globulus and Tinospora cordifolia were determined by XTT assay on MCF-7 cell lines. The results are discussed in comparison of Natural with pollutant grown plants. The plants that showed better production of phytochemicals due to the presence of metal elements could be recommended to phytopharmaceutical industries as they comparatively showed better production of phytochemicals further proposing a definite way to eliminate toxic metals from them.",signatures:"Sr. Prema Kumari Jonnada, Louis Jesudas and Varaprasad\nBobbarala",downloadPdfUrl:"/chapter/pdf-download/49693",previewPdfUrl:"/chapter/pdf-preview/49693",authors:[{id:"90574",title:"Dr.",name:"Varaprasad",surname:"Bobbarala",slug:"varaprasad-bobbarala",fullName:"Varaprasad Bobbarala"},{id:"176247",title:"Dr.",name:"Prema Kumari",surname:"Jonnada",slug:"prema-kumari-jonnada",fullName:"Prema Kumari Jonnada"},{id:"176248",title:"Prof.",name:"Louis",surname:"Jesudas",slug:"louis-jesudas",fullName:"Louis Jesudas"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"2129",title:"A Search for Antibacterial Agents",subtitle:null,isOpenForSubmission:!1,hash:"1567c6402f459b018a6aabfd620aa3f7",slug:"a-search-for-antibacterial-agents",bookSignature:"Varaprasad Bobbarala",coverURL:"https://cdn.intechopen.com/books/images_new/2129.jpg",editedByType:"Edited by",editors:[{id:"90574",title:"Dr.",name:"Varaprasad",surname:"Bobbarala",slug:"varaprasad-bobbarala",fullName:"Varaprasad Bobbarala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1406",title:"Antimicrobial Agents",subtitle:null,isOpenForSubmission:!1,hash:"716194563847e4c8e0f4a7c07ff858ed",slug:"antimicrobial-agents",bookSignature:"Varaprasad Bobbarala",coverURL:"https://cdn.intechopen.com/books/images_new/1406.jpg",editedByType:"Edited by",editors:[{id:"90574",title:"Dr.",name:"Varaprasad",surname:"Bobbarala",slug:"varaprasad-bobbarala",fullName:"Varaprasad Bobbarala"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8427",title:"Antimicrobials, Antibiotic Resistance, Antibiofilm Strategies and Activity Methods",subtitle:null,isOpenForSubmission:!1,hash:"0fdedc9bf6c23241235a0ae011c0304c",slug:"antimicrobials-antibiotic-resistance-antibiofilm-strategies-and-activity-methods",bookSignature:"Sahra Kırmusaoğlu",coverURL:"https://cdn.intechopen.com/books/images_new/8427.jpg",editedByType:"Edited by",editors:[{id:"179460",title:"Associate Prof.",name:"Sahra",surname:"Kırmusaoğlu",slug:"sahra-kirmusaoglu",fullName:"Sahra Kırmusaoğlu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6978",title:"Antimicrobial Resistance",subtitle:"A Global Threat",isOpenForSubmission:!1,hash:"949e88946357845e5843b4d7fbc1701f",slug:"antimicrobial-resistance-a-global-threat",bookSignature:"Yashwant Kumar",coverURL:"https://cdn.intechopen.com/books/images_new/6978.jpg",editedByType:"Edited by",editors:[{id:"79718",title:"Dr.",name:"Yashwant",surname:"Kumar",slug:"yashwant-kumar",fullName:"Yashwant Kumar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"4759",title:"Antimicrobial Resistance",subtitle:"An Open Challenge",isOpenForSubmission:!1,hash:"04be7bb9b8da174cdb838a38c75236b4",slug:"antimicrobial-resistance-an-open-challenge",bookSignature:"Maria Cristina Ossiprandi",coverURL:"https://cdn.intechopen.com/books/images_new/4759.jpg",editedByType:"Edited by",editors:[{id:"80691",title:"Prof.",name:"Maria Cristina",surname:"Ossiprandi",slug:"maria-cristina-ossiprandi",fullName:"Maria Cristina Ossiprandi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9521",title:"Antimicrobial Resistance",subtitle:"A One Health Perspective",isOpenForSubmission:!1,hash:"30949e78832e1afba5606634b52056ab",slug:"antimicrobial-resistance-a-one-health-perspective",bookSignature:"Mihai Mareș, Swee Hua Erin Lim, Kok-Song Lai and Romeo-Teodor Cristina",coverURL:"https://cdn.intechopen.com/books/images_new/9521.jpg",editedByType:"Edited by",editors:[{id:"88785",title:"Prof.",name:"Mihai",surname:"Mares",slug:"mihai-mares",fullName:"Mihai Mares"}],equalEditorOne:{id:"190224",title:"Dr.",name:"Swee Hua Erin",middleName:null,surname:"Lim",slug:"swee-hua-erin-lim",fullName:"Swee Hua Erin Lim",profilePictureURL:"https://mts.intechopen.com/storage/users/190224/images/system/190224.png",biography:"Dr. Erin Lim is presently working as an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates and is affiliated as an Associate Professor to Perdana University-Royal College of Surgeons in Ireland, Selangor, Malaysia. She obtained her Ph.D. from Universiti Putra Malaysia in 2010 with a National Science Fellowship awarded from the Ministry of Science, Technology and Innovation Malaysia and has been actively involved in research ever since. Her main research interests include analysis of carriage and transmission of multidrug resistant bacteria in non-conventional settings, besides an interest in natural products for antimicrobial testing. She is heavily involved in the elucidation of mechanisms of reversal of resistance in bacteria in addition to investigating the immunological analyses of diseases, development of vaccination and treatment models in animals. She hopes her work will support the discovery of therapeutics in the clinical setting and assist in the combat against the burden of antibiotic resistance.",institutionString:"Higher Colleges of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"3",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Perdana University",institutionURL:null,country:{name:"Malaysia"}}},equalEditorTwo:{id:"221544",title:"Dr.",name:"Kok-Song",middleName:null,surname:"Lai",slug:"kok-song-lai",fullName:"Kok-Song Lai",profilePictureURL:"https://mts.intechopen.com/storage/users/221544/images/system/221544.jpeg",biography:"Dr. Lai Kok Song is an Assistant Professor in the Division of Health Sciences, Abu Dhabi Women\\'s College, Higher Colleges of Technology in Abu Dhabi, United Arab Emirates. He obtained his Ph.D. in Biological Sciences from Nara Institute of Science and Technology, Japan in 2012. Prior to his academic appointment, Dr. Lai worked as a Senior Scientist at the Ministry of Science, Technology and Innovation, Malaysia. His current research areas include antimicrobial resistance and plant-pathogen interaction. His particular interest lies in the study of the antimicrobial mechanism via membrane disruption of essential oils against multi-drug resistance bacteria through various biochemical, molecular and proteomic approaches. Ultimately, he hopes to uncover and determine novel biomarkers related to antibiotic resistance that can be developed into new therapeutic strategies.",institutionString:"Higher Colleges of Technology",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"8",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Higher Colleges of Technology",institutionURL:null,country:{name:"United Arab Emirates"}}},equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"73639",slug:"corrigendum-to-single-photon-emission-computed-tomography-spect-radiopharmaceuticals",title:"Corrigendum to: Single-Photon Emission Computed Tomography (SPECT) Radiopharmaceuticals",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/73639.pdf",downloadPdfUrl:"/chapter/pdf-download/73639",previewPdfUrl:"/chapter/pdf-preview/73639",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/73639",risUrl:"/chapter/ris/73639",chapter:{id:"73033",slug:"single-photon-emission-computed-tomography-spect-radiopharmaceuticals",signatures:"Syed Ali Raza Naqvi and Muhammad Babar Imran",dateSubmitted:"May 13th 2019",dateReviewed:"July 22nd 2020",datePrePublished:"August 21st 2020",datePublished:"January 7th 2021",book:{id:"7769",title:"Medical Isotopes",subtitle:null,fullTitle:"Medical Isotopes",slug:"medical-isotopes",publishedDate:"January 7th 2021",bookSignature:"Syed Ali Raza Naqvi and Muhammad Babar Imrani",coverURL:"https://cdn.intechopen.com/books/images_new/7769.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",fullName:"Syed Ali Raza Naqvi",slug:"syed-ali-raza-naqvi",email:"drarnaqvi@gmail.com",position:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"302793",title:"Dr.",name:"Muhammad Babar",middleName:null,surname:"Imran",fullName:"Muhammad Babar Imran",slug:"muhammad-babar-imran",email:"muhammadbabarimran@yahoo.com",position:null,institution:null}]}},chapter:{id:"73033",slug:"single-photon-emission-computed-tomography-spect-radiopharmaceuticals",signatures:"Syed Ali Raza Naqvi and Muhammad Babar Imran",dateSubmitted:"May 13th 2019",dateReviewed:"July 22nd 2020",datePrePublished:"August 21st 2020",datePublished:"January 7th 2021",book:{id:"7769",title:"Medical Isotopes",subtitle:null,fullTitle:"Medical Isotopes",slug:"medical-isotopes",publishedDate:"January 7th 2021",bookSignature:"Syed Ali Raza Naqvi and Muhammad Babar Imrani",coverURL:"https://cdn.intechopen.com/books/images_new/7769.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",fullName:"Syed Ali Raza Naqvi",slug:"syed-ali-raza-naqvi",email:"drarnaqvi@gmail.com",position:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"302793",title:"Dr.",name:"Muhammad Babar",middleName:null,surname:"Imran",fullName:"Muhammad Babar Imran",slug:"muhammad-babar-imran",email:"muhammadbabarimran@yahoo.com",position:null,institution:null}]},book:{id:"7769",title:"Medical Isotopes",subtitle:null,fullTitle:"Medical Isotopes",slug:"medical-isotopes",publishedDate:"January 7th 2021",bookSignature:"Syed Ali Raza Naqvi and Muhammad Babar Imrani",coverURL:"https://cdn.intechopen.com/books/images_new/7769.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11500",leadTitle:null,title:"Multi-Objective Optimization",subtitle:null,reviewType:"peer-reviewed",abstract:"This book will be a self-contained collection of scholarly papers targeting an audience of practicing researchers, academics, PhD students and other scientists. The contents of the book will be written by multiple authors and edited by experts in the field.",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,hash:"221a460c3b8962d71cab3475f0b22e93",bookSignature:"",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11500.jpg",keywords:null,numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 27th 2021",dateEndSecondStepPublish:"October 18th 2021",dateEndThirdStepPublish:"December 17th 2021",dateEndFourthStepPublish:"March 7th 2022",dateEndFifthStepPublish:"May 6th 2022",remainingDaysToSecondStep:"7 months",secondStepPassed:!0,currentStepOfPublishingProcess:1,editedByType:null,kuFlag:!1,biosketch:null,coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"15",title:"Mathematics",slug:"mathematics"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:null},relatedBooks:[{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"314",title:"Regenerative Medicine and Tissue Engineering",subtitle:"Cells and Biomaterials",isOpenForSubmission:!1,hash:"bb67e80e480c86bb8315458012d65686",slug:"regenerative-medicine-and-tissue-engineering-cells-and-biomaterials",bookSignature:"Daniel Eberli",coverURL:"https://cdn.intechopen.com/books/images_new/314.jpg",editedByType:"Edited by",editors:[{id:"6495",title:"Dr.",name:"Daniel",surname:"Eberli",slug:"daniel-eberli",fullName:"Daniel Eberli"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"57",title:"Physics and Applications of Graphene",subtitle:"Experiments",isOpenForSubmission:!1,hash:"0e6622a71cf4f02f45bfdd5691e1189a",slug:"physics-and-applications-of-graphene-experiments",bookSignature:"Sergey Mikhailov",coverURL:"https://cdn.intechopen.com/books/images_new/57.jpg",editedByType:"Edited by",editors:[{id:"16042",title:"Dr.",name:"Sergey",surname:"Mikhailov",slug:"sergey-mikhailov",fullName:"Sergey Mikhailov"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1373",title:"Ionic Liquids",subtitle:"Applications and Perspectives",isOpenForSubmission:!1,hash:"5e9ae5ae9167cde4b344e499a792c41c",slug:"ionic-liquids-applications-and-perspectives",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/1373.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"38496",title:"Reachability Criterion with Sufficient Test Space for Ordinary Petri Net",doi:"10.5772/50518",slug:"reachability-criterion-with-sufficient-test-space-for-ordinary-petri-net",body:'
Petri nets (PN) are widely recognized as a powerful tool for modelling and analyzing discrete event systems, especially systems are characterized by synchronization, concurrency, parallelism and resource sharing [1, 2]. One of the major advantages of using Petri net models is that the PN model can be used for the analysis of behaviour properties and performance evaluation, as well as for systematic construction of discrete-event simulators and controllers [3, 4]. The reachability from an initial marking to a destination marking is the most important issue for the analysis of Petri nets. Many other problems such as liveness and coverability can be deduced from this reachability problem [5, 6].
Two basic approaches are usually applied to solve the reachability problem. One is the construction of reachability tree [7, 8]. It can obtain all the reachable markings, but the computation complexity is exponentially increased with the size of a PN. The other is to solve the state equation [9]. The solution of the matrix equation provides a firing count vector that describes the relation between initial marking and reachable markings. Its major problem is the lack of information of firing sequences and the existence of spurious solutions.
Many researchers have investigated the reachability problem [10, 11]. Iko Miyazawa
In most cases, it is not necessary to find all reachable markings. One of the most important things is to know whether a given marking is reachable or not. If the destination marking Md is reachable from the initial marking M0, it is significant to find a firing sequence, which is an ordered sequence of transitions that lead M0 to Md. The following method can be utilized to find a reachable marking [15].
Solve the equation AX=Md-M0 to ascertain all the solutions X1, X2, … and construct the set X={X1, X2, …}.
Test if Xi in X is an executable solution from M0, i.e. there is at least one sequence S(Xi) that is a firing sequence under M0.
If an executable solution exists, then Md is reachable. On the contrary, if X=Ф or all solutions are spurious, then Md is not reachable.
However, this approach is theoretic rather than practical, because there are two problems: One is that the solution of the fundamental equation AX=Md-M0 is infinite in some cases. In that case, it is impossible to test all solution Xi. The other is that the computation complexity of testing Xi increases at least exponentially as the length of S(Xi) increases.
In this chapter, the above two problems will be solved as follows: First, we construct a sufficient test space to include at least one executable solution within set X. An approach is secondly proposed to test whether there is an executable solution within the sufficient test space or not. A systematic method to search an executable solution in a sufficient test space and to enumerate the associated firing sequence is presented.
The remainder of the chapter is arranged as follows: Definitions and notations required in this chapter are given in Section 2. Section 3 describes how to determine the sufficient test space for the reachability problem. In Section 4, an algorithm is developed to determine if Xi is a executable solution under M0 and gives the associated firing sequence S(Xi). The illustrative examples are given in Section 3, Section 4, and Section 5.
In this section, we present some definitions and notations to be necessary in the following sections.
Definition 1. Let PN=(P, T, I, O, M0) be a marked Petri net. P={p1, p2, …, pn} is the finite set of places. T={t1, t2, …, tm} is the finite set of transitions. I is the input function. O is the output function. M0 is the initial marking.
A PN is an ordinary Petri net iff I(p, t)→{0, 1} and O(t, p)→{0, 1} for any p∈P and t∈T. A=O-I is the incidence matrix, where O and I are the output and input function matrices [16]. Let X=[x1 x2 … xm]T be a column vector. If X is the firing count vector of S(X), the sequence S(X) is called the transition sequence associated with X. The transition set T(X) is called the support of X if it is composed of transitions associated with positive elements of X, i.e. T(X)={ti|xi>0}. p is the set of output transitions of p, p is the set of input transitions of p, t is the set of output places of t, and t is the set of input places of t.
Definition 2. Ci=<p, Tci> is called a conflict structure [17] if it satisfies the following condition: Tci={t|t∈p} and |Tci|≥2, where |Tci| is the cardinality of Tci. We note that C={C1, C2, …} is the set of all Ci and Tc=Tc1∪Tc2∪…. is the set of all conflict transitions.
Definition 3. For transition tj and X, the sub-vector H(tj|X) is defined as: H(tj|X)=
Definition 4. For the conflict structure Ci=<p, Tci> and X, the sub-vector H(Ci|X) is defined as follows:
Definition 5. Ci=<p, Tci> is in a spurious conflict state for X under M if there exists a firing sequence S(H(Ci|X)) under M, i.e. the mathematic criterion is M≥IH(Ci|X).
Otherwise, Ci is in an effective conflict state for X under M, and the transition in Tci is called the effective conflict transition for X under M.
Notation 1. N(tj|S(X))=xj is the number of occurrence times of tj in S(X).
Notation 2. If q=min{M(pi), pi∈tj}, we call tj q-enabled under marking M. This q is denoted as E(tj|M).
Definition 6. F=[f1 f2 … fm]T is called an actual firing vector whose j-th element is fj=min{N(tj|S(X)), E(tj|M)}. F can be partitioned into two parts as follows: F=Fo+Fc, where Fc=[fc1 fc2 … fcm]T is associated with effective conflict transitions, Fo =[fo1 fo2 … fom]T is associated with the other transitions. Fo and Fc satisfy the following conditions:
If tj is an effective conflict transition for X under M, then foj=0 and fcj=fj.
Otherwise, fcj=0 and foj=fj.
If all the solutions of the equation AX=Md-M0 are tested, It can be found whether Md is reachable or not. But in some case, the solutions are infinite. Therefore, the tested range is determined in order to keep the method practical. This range must be finite and include at least one executable solution if it exists. This section will discuss how to determine the tested range.
Definition 7. Given the initial marking M0 and the destination marking Md of a PN, X is a solution of AX=Md-M0. If Md is reachable from M0 under X, then X is called an executable solution. Otherwise, X is called a spurious solution.
Definition 8. X={X1, X2, … } is the set of a solution X, the subset Xe={Xe1, Xe2, … } of X is called the sufficient test space if it satisfies following conditions:
If Md is reachable from M0, there must exist at least one element in Xe which is executable solution; in other words, if all elements in Xe are not executable, then all the elements in X are not executable either.
Xe is a finite set.
Definition 9. The vector X which is a solution of AX=0 is known as a T-invariant [18]. A solution X is called positive if every element of X is nonnegative.
Definition 10. The positive T-invariant solution U of AU=0 is minimal if it satisfies the following condition: for any other T-invariant Ui, at least one element of U-Ui is negative. The set of minimal T-invariant solutions is U={U1, U2, …, Us}.
Definition 11. The positive particular solution V of AV=Md-M0 is minimal if it satisfies the following condition: for any T-invariant U of PN, there must be at least one element in V-U which is negative, i.e. {U|V-U≥0, U is a T-invariant}=Ф. The set of minimal particular solutions is V={V1, V2, …, Vq}.
The general solution of AX=Md-M0 must be expressed by the form of one minimal particular solution and the arbitrary linear combination of the T-invariant solutions as follows:
where Vi∈V, kj is nonnegative integer.
Algorithm 1. Interpretation of the computation for Xe.
Solve the equation AX=0, get all the positive integer solutions U={U1, U2, …, Us}, where each Uj (1js) is a minimal T-invariant.
Solve the equation AX=Md-M0, get all the positive integer particular solutions V={V1, V2, …, Vq}, where each Vi (1iq) is a minimal particular solution. B={B1, B2, …, Bn} is a subset of V.
If V= Ф, Md is not reachable, then end.
Initialization: Let Xe=V={V1, V2 …, Vq} and Xtemp= Ф.
If U= Ф, then end.
Otherwise, for every Vi, if T(Vi)T(Uj), then ViB. If T(Vi)T(Uj), then ViB.
Go to Step 4.
For each pair of (Bi, Uj), where i=1, 2, … |B|, j=1, 2, … s, and |B| is the cardinality of set B, carry out the following operations:
If T(Bi)∩T(Uj) = Ф, choose the next pair of (Bi, Uj).
If T(Bi)∩T(Uj) ≠ Ф and T(Uj)
If T(Bi)∩T(Uj) ≠ Ф and T(Uj)
Let Di(r) be the r-th elememt of Di.
Wi(r)=f(Di(r)), where
Add Bi+kUj, k=1, 2, … β, to Xtemp
When all pairs of (Bi, Uj) have been tested, go to Step 5.
If Xtemp= Ф, then end.
Otherwise, Let B=Xtemp, Xe=XeB, Xtemp= Ф, go to Step 4.
Step 1 and Step 2 are to determine all the positive integer solutions X for equation AX=Md-M0. The firing count vector of any firing sequence from M0 to Md belongs to X. In Step 4, if Bi is not an executable solution, then there must be some transitions in T(Bi) which aren’t enable it, i.e. some places in T(Bi) are lack of tokens. In this case, if {p|p∈T(Bi)∩T(Uj) and T(Uj)
The following examples show how to implement the computation algorithm. These examples illustrate that suppressing any ki in Bi+kUj, k=1, 2, … β, may eliminate some possible executable solutions.
Example 1. When the initial marking is M0=(1,0,0,0,0,1,0,0,0) and the destination marking is Md=(1,0,0,0,0,0,0,0,1) in Figure 1, calculate the sufficient test space Xe. The ● and ○ symbols are represented as the initial and destination markings respectively.
Solve the equation AX=0, get the positive integer minimal T-invariant U1=(1,1,1,1,0,0,0,0).
Solve the equation AX=Md-M0, get the positive integer minimal particular solution V={V}=(0,0,0,0,1,1,1,1)
Initialization: Let Xe=V, Xtemp= Ф, B=Xe
Step 4-1.For (V, U1),
If T(U1)
Then add V+U1, V+2U1, V+3U1 to the set of Xtemp,
Therefore, Xtemp={V+U1, V+2U1, V+3U1}
Step 5-1.If Xtemp≠Φ, then let B=Xtemp={V+U1, V+2U1, V+3U1}
Xe=XeB={V, V+U1, V+2U1, V+3U1}, Xtemp=Φ.
Go to Step4 in Algorithm 1.
Step 4-2.For any pair of (Bi, U1), T(U1)
Step 5-2.If Xtemp=Φ, then end.
As a result of above sequence, Md is reachable from M0. The firing sequence is t5*t1*t2*t6*t7*t3*t4*t8. Its firing count vector corresponds to V+U1=(1,1,1,1,1,1,1,1) in the sufficient test space Xe. This example shows that suppressing Bi+kUj (k=1) in Xe may eliminate some possible executable solution.
Example 2. Consider the PN of Figure 2, given the initial marking M0=(1,0,0,0,0,0,0,0,1,0) and the destination marking Md=(0,0,0,1,0,0,0,0,1,0), calculate the sufficient test space Xe.
Petri net structure
Petri net structure
Solve the equation AX=0, two positive integer minimal T-invariants are obtained: U1=(0,0,0,1,1,1,1,0,0,0), U2=(0,0,0,0,0,0,0,0,1,1)
Solve the equation AX=Md-M0, get the positive integer minimal particular solutions V={V}={(1,1,1,0,0,0,0,1,0,0)}
The general solution can be expressed as follows:
k1 and k2 are nonnegative integer.
Initialization: Let Xe=V, Xtemp=Φ, B=Xe
Step 4-1. For (V, U1),
If T(U1)
Then add V+U1, V+2U1 to Xtemp. So Xtemp={V+U1, V+2U1}
For (V, U2),
If T(U2)
Then add V+U2 to Xtemp. So Xtemp={V+U1, V+2U1, V+U2}
Step 5-1. If Xtemp≠Φ, then let B=Xtemp={V+U1, V+2U1, V+U2},
Xe=XeB={V, V+U1, V+2U1, V+U2}. Let’s put Xtemp=Φ.
Go to Step 4 in Algorithm 1.
Step 4-2.For (V+U1, U1), because T(U1)T(V+U1), choose the next pair.
For (V+U1, U2),
If T(U2)
=2
.Then add V+U1+U2 and V+U1+2U2 to Xtemp. So Xtemp={V+U1+U2, V+U1+2U2}
For (V+2U1, U1), because T(U1)T(V+2U1), choose the next pair.
For (V+2U1, U2),
If T(U2)
=3.
Then add V+2U1+U2, V+2U1+2U2, and V+2U1+3U2 to Xtemp. So Xtemp={V+U1+U2, V+U1+2U2, V+2U1+U2, V+2U1+2U2, V+2U1+3U2}
For (V+U2, U2), because T(U2)T(V+U2), choose the next pair.
For (V+U2, U1),
If T(U1)
=3.
Then add V+U2+U1, V+U2+2U1, and V+U2+3U1 to Xtemp. So Xtemp={V+U1+U2, V+U1+2U2, V+2U1+U2, V+2U1+2U2, V+2U1+3U2, V+U2+3U1}
Step 5-2.If Xtemp≠Φ, then let B=Xtemp={V+U1+U2, V+U1+2U2, V+2U1+U2, V+2U1+2U2, V+2U1+3U2, V+U2+3U1}.
So, Xe=Xe+B={V, V+U1, V+2U1, V+U2, V+U1+U2, V+U1+2U2, V+2U1+U2, V+2U1+2U2, V+2U1+3U2, V+U2+3U1}. Let’s put Xtemp=Φ.
Go to Step 4 in Algorithm 1.
Step 4-3.For any pair of (Bi, Uj), because T(Uj) T(Bi), Xtemp=Φ
Step 5-3.If Xtemp=Φ, then end
Md is reachable from M0. The firing sequence is t9*t7*t4*t1*t5*t6*t7*t2*t4*t5*t6*t10*t3*t8. Its firing count vector corresponds to V+2U1+U2=(1,1,1,2,2,2,2,1,1,1) in the sufficient test space Xe. This example illustrates that suppressing Bi+kUj (k=β) in Xe may eliminate some possible executable solution.
Given the initial marking M0 and the destination marking Md of a PN, a solution Xei is solved from AX=Md-M0. Then, an algorithm is developed to determine whether Md is reachable from M0 under Xei or not. If Md is reachable from M0, the algorithm gives the associated firing sequence S(Xei).
Definition 12. Let S= t1t2…tr be a finite transition sequence. The transitions appearing in S are defined by the set Z(S) ={t1, t2, …, tr}. The set of transitions Z(S) is called a sequence component. Z(S) is the set of elements that appear in a transition sequence S.
Algorithm 2. Search of a firing sequence S(Xei) under M0
According to I, determine all the conflict structure Ci=<p, Tci>, and construct Tc and C.
Initialization: Let
Under
If Fo≠0, go to Step 4.
If Fo =0 and Fc≠0, go to Step 5.
If F=0, go to step 6.
Step 4. If Fo≠0, then there exists an S(Fo) that has a firing sequence under
Let
Fo =0 and Fc≠0 means that all transitions in S(Fc) are effective conflict transitions. Therefore, branching occurs and the number of branches is |T(Fc)|. From here, the computation has to consider all |T(Fc)| branches.
After selecting a transition tj∈T(Fc), fire it, then the reachable marking is calculated by M’=
Let
Step 6. If
If all the branches in Step 5 have been implemented, then Md is not reachable, end. Otherwise, go to Step 5 and implement the remaining branches.
The validity of the above algorithm is proved as the following four cases:
Base: Let X be a solution of AX=Md-M0. The actual firing vector F=Fo+Fc is obtained with M and X. Let to∈T(Fo) and tc∈T(Fc).
Case 1: If Fo≠0 and Fc=0, then multiple firing of S(Fo) doesn’t affect a firing sequence associated with X under M0, for the input places of T(Fo) don’t affect the enabling condition of other transitions in T(X) except transitions in T(Fo).
Case 2: If Fo=0 and Fc≠0, then the firing of each transition in S(Fc) is considered as a branch and implemented with respect to all branches. It means that all possibilities are involved. So, Algorithm 2 doesn’t eliminate any possible firing sequence.
Case 3: If Fo=0 and Fc=0, then no transition is enabled.
Case 4: If Fo≠0 and Fc≠0, then the multiple firing of S(Fo) can be implemented before S(Fc). It doesn’t eliminate any probability of finding a firing sequence associated with X under M0. It is proven in Proposition 1.
Proposition 1. If σ∈S(X) is a firing sequence under M0, then (S(Fo)*σ’)∈S(X) is a firing sequence under M0 for any sequence σ’.
Proof:
Let T(Fo)={to1, to2, …, ton}. For a transition to1∈T(Fo), σ can be represented as σ =σ1*to*σ2, where to1Z(σ1). Then M0
Under M3, let’s consider the new T(Fo)={to2, …, ton}T(Fo’), where T(Fo’) is the set of transition generated after to1 firing and may be empty. For a transition to2∈T(Fo), σ1*σ2 can be represented as σ1*σ2=σ3*to2*σ4, where to2Z(σ3). Then σ3*to2*σ4 is a firing sequence. By the same way described in Step 1, we can prove that to2*σ3*σ4 is a firing sequence under M3.
By Step 1 and Step 2, to1*to2*σ3*σ4 is a firing sequence under M0.
In the same way, it is proven that to1*to2*…*ton*σi*σj is a firing sequence under M0. According to the definition of Fo, all transitions in {to1, to2, …, ton} can fire simultaneously under M0. Let’s put σ’=σi*σj, then (S(Fo)*σ’)∈S(X) is a firing sequence under M0.
Example 3. Let us now apply the proposed algorithm to the PN of Figure 3. Given M0=(0,0,0,0,0,0,1,0,0), Md=(0,0,0,0,1,0,1,0,0) and X=(1,2,1,1,1,1,1), determine if Md is reachable or not under M0 and X.
Petri net structure
There are two conflict structures, C1=<p1, {t2, t5}>, C2=<p2, {t3, t4}>, Tc={t2, t3, t4, t5}.
Initialization:
Under
Fire S(Fo)= t6. Then the reachable marking M’ becomes (1,0,0,0,0,0,0,1,0)
Let
Step 3-1.Under
Step 4-1.Fire S(Fo)=t7. Then, the reachable marking becomes M’=(1,0,0,0,0,0,1,0,1)
Let
Step 3-2.Under
Step 4-2.Fire S(Fo)=t2 (t2 is not an effective conflict transition because t5 cannot enable),
then the reachable marking becomes M’=(0,1,0,0,1,0,1,0,1)
Let
Step 3-3.Under
Step 4-3.Fire S(Fo)=t3 (t3 is not an effective conflict transition because t4 cannot enable),
then the reachable marking becomes M’=(0,0,1,0,1,0,1,0,1)
Let
Step 3-4.Under
Step 6.Because
Step 7.There is no effective conflict transition i.e., no branch. Consequently, Md is not reachable under X because
The above implementing process can be presented by a firing path tree as shown in Figure 4.
An example will be given to illustrate how to use the proposed method of Algorithm 1 and Algorithm 2 to solve the reachability problem.
Example 4. When the initial marking is M0=(1,0,0,0,0,0,0,0,1) in the PN of Figure 5, is the destination marking Md=(0,0,1,0,1,0,0,0,1) reachable from M0 ?
First, calculate sufficient test space using the following steps:
Solve the equation AX=0, get one positive integer minimal T-invariant U=(0,0,0,0,0,0,1,1).
Solve the equation AX=Md-M0, get the positive integer minimal particular solutions V1=(0,2,1,0,2,2,0,0), V2=(2,2,1,2,0,0,0,0) and V3=(1,2,1,1,1,1,0,0)
Initialization: Let Xe={V1, V2, V3}, Xtemp=Φ, B=Xe
Step 4-1 For (V1, U),
Firing path tree on reachability of
Petri net structure
If T(U)
Then add V1+U, V1+2U to Xtemp. Then, Xtemp={V1+U, V1+2U }
For (V2, U), because T(V2)∩T(U) =Φ, choose the next pair.
For (V3, U),
If T(U)
Then add V3+U to Xtemp, Xtemp={V1+U, V1+2U, V3+U}
Step 5-1 If Xtemp≠Φ, then let B=Xtemp={V1+U, V1+2U, V3+U},
Xe=XeB={V1, V2, V3, V1+U, V1+2U, V3+U }. Let’s put Xtemp=Φ. Go to Step 4 in Algorithm 1.
For any pair of (Bi, U), because T(Uj)
If Xtemp=Φ, then end.
Consequently, the sufficient test space becomes Xe={V1, V2, V3, V1+U, V1+2U, V3+U}.
Second, calculate a firing sequence in order to test if M(d) is reachable from M(0) under some element in Xe
The elements of the sufficient test space Xe are calculated separately as follows:
For X=V1=(0,2,1,0,2,2,0,0)
The implementing process is shown in Figure 6.
For X=V2=(2,2,1,2,0,0,0,0)
Carrying out the same process, the conclusion is as follows: Md is not reachable under V2.
For X=V3=(1,2,1,1,1,1,0,0)
Carrying out the same process, the conclusion is as follows: Md is not reachable under V2.
For X=V1+U=(0,2,1,0,2,2,1,1)
Carrying out the same process shown in Figure 7, the conclusion is as follows: Md is reachable from M0 under V1+U. V1+U is an executable solution in Xe, and the firing sequence is t5*t7*t6*t2*t3*t5*t6*t2*t8.
As a result of calculating each element of the sufficient test space Xe={V1, V2, V3, V1+U, V1+2U, V3+U} individually, a firing sequence is finally found at the fourth element (V1+U) of Xe. Therefore, the elements V1+2U and V3+U don’t need to be calculated. Consequently, the structure of the Petri net (Figure 5) is shown to possess at least one reachable firing sequence.
Firing path tree for V1.
Firing path tree for V1+F.
In this chapter, a new general criterion has been created to solve the reachability problems for ordinary Petri nets. This criterion is based on two processes: (i) Calculating the sufficient test space. (ii) Testing whether or not the destination marking is reachable from the initial marking under the sufficient test space. The sufficient test space significantly reduces the quantity of computation needed to search for an executable solution in X. The firing path tree shows the firing sequence of an executable solution. Consequently, if the destination marking is reachable from the initial marking, this method gives at least one firing sequence that leads from the initial marking to the destination marking. Some examples are given to illustrate how to use this method to solve the reachability problem. This algorithm can be utilized in the following fields: Path searching, auto routing, and reachability between any places in a complicated network.
The discovery of a new drug can usually take 10-15 years [1, 2]. Within this time period, the candidate drug is screened for its beneficial as well as for its side effects (Figure 1). But the side, adverse or toxic effects cannot be detected to a full scale due to some special reasons.
Steps of drug development and commercialization.
Adverse Drug Reaction (ADR) is a damage or injury response caused due to intake of medication [3]. The ADRs may arise after administration of a single dose, or long-term administration of any drug or consequence of the administration of two or more drugs as a combination product or separately [4]. The study of ADRs has turned to be a separate field of science and is known as Pharmacovigilance (PV), which is defined by the World Health Organization (WHO) as, “the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem” [5]. The Program for International Drug Monitoring (PIDM) was established by WHO in 1968 in response to the tragedy caused by thalidomide in 1961. The “Thalidomide Tragedy” was related to the birth of children with deformed limbs, also known as phocomelia [6], and it became one of the most known tragedies in the history of medical and pharmaceutical sciences. The WHO encourages, supports and promotes PV at the country level for its member countries, and offers collaboration through its Collaborating Centre for International Drug Monitoring in Uppsala, Sweden [7]. Until March 2019, the total number of member states which have enrolled in the WHO PIDM as a member corresponds to 142 and, additionally 29 associate members are expecting full membership [8].
To prevent tragedies such as the thalidomide disaster, governments all over the world took necessary ethical and legal actions and strengthened their drug regulatory authorities (DRAs) to keep alert and to ensure the marketing of relatively safe drugs.
An ADR can be defined as “any response to a drug which is noxious and unintended, and which occurs at doses used in man for prophylaxis, diagnosis or therapy of disease, or for the modification of physiological function” [9].
As we have mentioned earlier, the overall toxicity of a drug is clearly understood during the whole life cycle of a drug, while only a minor portion of these toxicities are unveiled during clinical trial phases. After global launching, the post market surveillance studies help to assess the information leading to drug withdrawals, safety alerts from regulatory authorities and changes in product labelling. This also triggers the advances in pharmacology and therapeutics. Directly or indirectly, reports of ADR studies have shaped much of the current drug regulatory framework and contributed significantly to drug regulatory decisions. Furthermore, some ADR reports have also proved to be valuable weapons in discoveries in pharmacology and in improving drug use [10]. Clinical trial phases [11] include a small number of population and many clinical trials usually exclude:
Children,
Old people,
Pregnant and lactating women,
Ethnic groups,
Peoples with genetic disorders and,
People with liver and kidney insufficiency.
During the development of a drug, only less than 50% of ADRs can usually be detected, with the remaining more than 50% being detected after global launching, during the whole life cycle of the product. This can be compared with tip of the iceberg, which indicates a minor part of a major problem (Figure 2).
The schematic diagram of an iceberg [
That is why it is very important to study the ADRs after launching of a new drug or vaccine.
As will be mentioned and described below, the “Thalidomide-induced Phocomelia” led the drug regulatory authority to take rigorous actions, including regulatory actions against the drug and promulgation of regulatory guidelines, as well as legislation. This and other reports have helped to discover a number of major drug disasters, such as the Benoxaprofen (known to cause severe hepatotoxicity and a variety of cutaneous reactions), Torsadogenic Drugs (e.g., prenylamine, terfenadine, cisapride that caused QT prolongation), Practolol (known to cause exfoliative dermatitis, systemic lupus syndrome, drug eruption, psoriasiform eruptions, skin reactions with eye signs consisting of atypical conjunctival shrinkage and xerosis, and keratoconjunctivitis sicca) [10]. In Bangladesh, the “Paracetamol tragedy” led the Directorate General of Drug Administration (DGDA) to take strict regulatory actions in the manufacture and quality control of drugs by the manufacturers. A few examples of those drug tragedies that occurred abroad and in Bangladesh are discussed below.
In December 1961, William McBride, an Australian obstetrician, alerted in a letter to the
The first page of the letter to the editor published in the scientific journal ‘The Lancet’, in 1961, on the adverse effects of thalidomide.
The letter the first printed and published suggestion from a medical doctor about the teratogenic effect of thalidomide in women and it was a brief publication containing only five sentences. Dr. McBride’s apprehensions about the drug thalidomide were eventually settled by numerous babies who were born with birth defects [14, 15].
In 2016, a
William Griffith McBride was born on the 25th of May 1927 in Sydney, Australia. As his mother was sick, he had to spend much of his early living with an aunt on a dairy farm. He pursued his study of medical sciences at Sydney University Medical School.
Dr. McBride attained global recognition for his contribution to alert everyone worldwide about the danger of the drug thalidomide, which have caused defects in the development of the limbs of the fetus and, ultimately, gave rise to the birth of truncated babies. In Australia, his own country, Dr. McBride was praised as a national hero, and a radiance of honor fell over him over the next three decades. He had a blooming practice in Sydney, and he was awarded with both the ‘Commander of the Order of the British Empire’ in 1969 and the Order of Australia in 1977.
But a later part of McBride’s life and work was not so pleasing. In 1993, when he was 65, McBride was found guilty of scientific deception by a medical court for the consciously publishing of erroneous and fallacious research. Consequently, his name was cut from the medical register [18, 19, 20].
An article reporting to the “Sulfanilamide Disaster” was published in June 1981 in an issue from the FDA Consumer magazine, and was entitled “Taste of Raspberries, Taste of Death: The 1937 Elixir Sulfanilamide Incident” [21]. The incident was described as: “By the 1930s it was widely recognized that the Food and Drugs Act of 1906 was obsolete, but bitter disagreement arose as to what should replace it. By 1937 most of the arguments had been resolved but Congressional action was stalled. Then came a shocking development: the deaths of more than 100 people after using a drug that was clearly unsafe. The incident hastened final enactment in 1938 of the Federal Food, Drug, and Cosmetic Act, the statute that today remains the basis for FDA regulation of these products”.
Sulfanilamide is used to treat streptococcal infections due to its curative effects and, at that time, was available in the form of tablet and powder dosage. The demand for the liquid dosage form was raised by a salesman of the S.E. Massengill Co., in Bristol, Tenn., and the company’s principal chemist and pharmacist, Harold Cole Watkins, who used diethylene glycol to dissolve sulfonamide and prepare an elixir. The quality control laboratory of the company analyzed the product for flavor, appearance and fragrance, and certified it as satisfactory. Instantly, the company considered it as a safe product, manufactured a certain quantity of it and sent product shipments to the whole country [21]. The new dosage form had not been analyzed for its toxicity and no pharmacological evaluation had been performed on the new sulfanilamide preparation. Watkins failed to record one feature of the elixir made by using diethylene glycol, which is applied as an antifreeze and is a lethal poison, causing renal damage followed by death [21].
Tylenol (Paracetamol) tragedy occurred in 1982 [22]. Tylenol was a product of of Johnson & Johnson and a trade-named drug intended for lessening pain, decreasing fever, and alleviating the symptoms of cough, cold, headache, allergies and influenza. The active pharmaceutical ingredient of this preparation is paracetamol (in the US it is known as acetaminophen), which is prescribed as an analgesic and antipyretic. The branded name (market name) Tylenol is accrued from a chemical name for the compound, N-acetyl-para-aminophenol (APAP). The branded name is possessed by McNeil Consumer Healthcare [22].
In 1982, in Chicago, US, Tylenol capsules laced with potassium cyanide caused the death of at least seven persons and raised a big concern about the safety of the marketed product. Potassium cyanide looks like normal table sugar, is water soluble but very toxic, being usually used for suicide (it is also known as suicide pills) [23].
This accident guided to the reforms in the packaging of over-the-counter drugs and to central anti-tampering laws. Johnson & Johnson took some necessary actions in their packaging and marketing policy that led to a reduction in the number of deaths and warned the public about potential poisoning risks. This action has been widely glorified as an exemplary public relation response to such a big crisis. Thus, Johnson & Johnson became able to regain their market share, which had been lost due to the Tylenol incident [22, 23, 24].
Two critical mishaps happened with paracetamol in Bangladesh. The first one occurred during 1990 to 1993, with the paracetamol produced by Adflame Pharmaceuticals Limited, and the second one took place during 2009 to 2010, with the paracetamol manufactured by Rid Pharmaceuticals Limited. These two incidents are described below.
i. Adflame Pharmaceuticals Limited (1990 – 1993)
From 1990 to 1992, about 339 children developed renal failure in Bangladesh, and most of them died, after being given paracetamol (acetaminophen) solution using diethylene glycol [25]. The drug was manufactured by the “Adflame Pharmaceuticals Limited”, Savar, Dhaka. The incident compelled the national government to forbid the trading of paracetamol preparations. Consequently, a decrease of 53% in the admission of victims with kidney failure and of 84% in admissions by unexplored kidney failure was observed in December 1992. This drug-related accident was reported in BMJ (Figure 4) in 1995 [25].
Publication in BMJ on the ‘paracetamol tragedy’ in Bangladesh by Hanif
Three persons of the Adflame Pharmaceutical company were given 10-years of rigorous jail for producing a spurious drug which slaughtered 76 children in the 1990s. These convicted persons were Helena Pasha (Director), Mizanur Rahman (Manager) and Nigendra Nath Bala (production officer).
The prosecution against the manufacturing entity Adflame was only one of the four others also involved in this petition. Three other pharmaceutical producers were also accused of manufacturing the same contaminated liquid paracetamol, including Polychem Laboratories Ltd., BCI (Bangladesh) Ltd., and Rex Pharmaceuticals. The fifth pharmaceutical industry - City Chemical and Pharmaceutical Works Ltd., was also sued but not trialed.
ii. Rid Pharmaceuticals Limited, Brahmanbaria (2009–2010)
Once more, in 2009, 28 children died due to the diethylene glycol toxicity [26]. The national government started to constitute a probe committee which detected the presence of the toxic substance diethylene glycol in the liquid paracetamol of one pharmaceutical company, after investigating 300 samples of liquid paracetamol and liquid vitamins of 10 industries. This company was supposed to use propylene glycol, but instead used the toxic diethylene glycol, a component applied in tannery and battery industries. Consequently, its manufactory was completely sealed off and its goods were re-called from the market [26].
In 2016, the drug court (at Dhaka) decided to exonerate all five persons from the Rid Pharmaceutical Industry Ltd., in the case where a poisonous paracetamol was produced and authorized by this company, leading to the death of 28 children all over the country in 2009. The Dhaka drug court judge Mr. Atoar Rahman issued the order on a Monday afternoon. In the verdict, the judge slammed the drug authority for “their inefficiency in handling the case before the drug court”. The judge said the prosecution had failed to demonstrate the charges due to the inability and inefficiency of the case investigation officer. Of the five officials, only Mizanur Rahman and his wife Sheuli were present during the delivery of the verdict. The rest of the accused persons are still absconding. The public prosecutor of this case, Dr. Nadim Miah, expressed his disappointment over the verdict by saying to the Dhaka Tribune: “We will decide on moving against the verdict after receiving the copy of the full verdict” [27]. Five prosecution witnesses gave depositions before the court during the trial, sources said. Twenty-eight children across Bangladesh died from renal failure during the period between June and August 2009, after consuming a paracetamol syrup manufactured by Rid Pharma. As the number of deaths was spread around the population, the government published notices in national daily newspapers warning people to not consume any drugs manufactured by this pharma company. A case was filed on August 10th, 2009, by the drug superintendent Shafiqul Islam with the Dhaka drug court against the five accused. Four more petitions were signed in Brahmanbaria, Comilla, Narayanganj and Sylhet. On July 22nd, 2009, the Directorate General of Drug Administration took steps to seal off the Rid Pharma’s factory at Brahmanbaria. The national government also constituted a seven-member enquiry committee to probe the matter. On July 29th, 2009, the enquiry committee submitted its report, referring that a poisonous chemical named diethylene glycol was used to manufacture the paracetamol syrup. The report also said that Rid Pharma used diethylene glycol, mainly applied in tannery and rubber industries, as a cheaper substitute of propylene glycol, since diethylene glycol costed Tk. 200 per liter, while propylene glycol costed Tk. 1,100 [26, 27, 28, 29].
The WHO has the responsibility to promote the health and hygiene of the people of its member countries. To perform this responsibility, WHO has taken a few programs. One of such programs is the Global Patient Safety Challenge. Till date, WHO has undertaken three Global Patient Safety Challenges, which are popularly known as ‘
First Global Patient Safety Challenge
Second Global Patient Safety Challenge:
3rd Global Patient Safety/Security Challenge:
These programs are almost self-explanatory, and a detailed description is out of the scope of this chapter.
According to WHO, PV can be defined as: “the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other drug-related problem” [31]. The term PV has been accrued from the Greek word
Aware/Alert;
Restraint/Forbearance of sleep, wakefulness;
Watchfulness in respect of jeopardy, care, caution;
The procedure of giving close and continuous attention.
From the definition given above, we see that there are four pillars of PV. These include:
Detection
Assessment
Understanding (Analysis) and
Prevention (Reporting) of ADR
The general aims of PV are to promote both patient care and patient safety with respect to the use of drugs and medical devices; and to bolster the public health programs (PHP) by giving reliable and equalized information for the productive estimation of the benefit–risk quotient of medicines [32].
The most important aims and purposes of PV are [32];
to alert people, not to scare them;
to boost the care and safety of the patient with respect to the consumption of medicines, medical devices and other healthcare interventions;
to improve the public health and safety, while using medicines;
to detect problems of medicine usage, reduce risks and communicate the observations in a disciplined way;
to contribute to the evaluation of benefit, hazard, effectiveness and dangers of medicines, directing to the curbing of harm and maximization of beneficial effects;
to embolden the safe, effective (i.e., cost-effective) and rational applications of medicines;
to enhance the understanding, education and the scientific and clinical tutelage in PV and its fruitful communication to the people.
It is well-known that PV is a risk management procedure for drugs. The process begins with identification of a possible danger, which is then assessed and investigated, ultimately resulting in actions that are taken to minimize those risks. The PV implementation requires the use of specific tools (Figures 5 and 6) that will help to communicate with the prescribers and end-users, and the last step should be an evaluation of the effectiveness of the process. The overall process of risk management is iterative due to new proofs that may emerge, or to certain measures taken that may be inadequate. A drug safety issue is rarely considered complete and the safety study goes on until the life cycle completion of the drug.
PV tools to detect and assess the signals related to ADRs.
Flow of information among PV centers and the global monitoring organizations by using PV analytical tools for ADRs analysis [
The beginning of the process is normally a ‘signal’ which is not often a real hazard. Before that can occur, there is a necessity to detect the signal.
The term ‘signal’ is defined by WHO as a “reported information on a possible causal relationship between an adverse event and a drug, the relationship being unknown or incompletely recorded previously” [34].
VigiBase is the starting point for the journey of Uppsala Monitoring Center (UMC) from data to wisdom regarding the safe use of drugs, as well as the sage therapeutic decisions in clinical practice. This is the motivating-force of the work of UMC and the WHO Program. The main aim of VigiBase is to make sure that initial signs of previously undetected, unknown, and unexplored drug-related safety problems are identified as quickly as possible.
VigiBase is one of the unique WHO global databases of individual case safety reports (ICSRs). This is the biggest database of its kind worldwide, with more than 20 million reported records of suspected adverse effects of drugs, which have been submitted since 1968 by member states of the WHO PIDM. VigiBase is continually updated with incoming reports from the member countries [35].
VigiFlow stands as a management procedure for recording, processing, and sharing reports of ADRs. VigiFlow collects the domestic data and processes the ICSR, thus sharing the reports for instance with VigiBase. This allows maximum local control and gives effective ways for management review and data scanning coming from national sources [36].
VigiLyze is a signal detection and management system using national, regional or global data as the launching point for quantitative signal detection. VigiLyze supports the overall signal management process, including the qualitative evaluation. The major strengths of this signal detection tool are its capacity to re-estimate disproportionality based on any selected country or region background within seconds, and re-investigate those for certainty using different tools [37]. VigiLyze will enable the users to search for any drug or reaction that is shared with the program from UMC, other national centers, or their own centers.
VigiLyze is accessible free of cost to national pharmacovigilance centers in all member states of the WHO Program for IDM. Under-reporting is a familiar matter in pharmacovigilance. By distributing the national reports of adverse events to the global database, individual nations can help increase all countries’ understanding of achievable safety concerns.
VigiLyze provides a national, regional, and global aspects of the suspected adverse effects of a drug. This enormous collection of data enhances assessments of surfacing domestic issues. Through VigiLyze it is possible to obtain easy entrance to post-marketing safety information for medicines that are new to the national market, but that are already marketed in other parts of the globe [38].
It is important to mention that one of the major concerns of PV is the safety issue of the PHP [39], such as vaccination in the form of national immunization day, administration of anthelmintics, administration of vitamin A capsule, etc. In those cases, PV tools act as very essential weapons to analyze the situations or adverse effects arising from mass drug administration [40] to handle the pandemics.
The Directorate General of Drug Administration (DGDA), under the ministry of Health and Family Welfare, is the national DRA of Bangladesh. The DGDA acts as the only PV center in Bangladesh. An Adverse Drug Reaction Monitoring (ADRM) cell has been set up under the DGDA in 1999 in Bangladesh [41]. The ADR reporting form was introduced in relevant medical institutions to collect information on ADRs. More recently, and under the ADRM, a PV cell was established to effectively monitor and collect the information on ADRs. However, PV is only one of the main components of effective medicine regulation by the national drug regulatory agencies. The vision of DGDA is to guarantee that effective, high-quality and safe drugs are available to the Bangladesh population. This can be achieved through an effective dissemination of the PV cell activities all over the country, including all public and private medical institutes, hospitals, clinics, public and private practitioners, pharmacists, nurses, and other health professionals (Figure 7). However, it is very important to keep in mind that the patients should always remain at the center of all [41].
Interrelationship among the different health professionals (physicians, pharmacists, nurses and health technologists) and the patients [
The main purpose of the PV study is to protect the future generations or the potential users from the harmful effects of a drug that has already launched in the market. Although the emergence of side effects resulting from the use of drugs are unavoidable, the incidence of morbidity and mortality caused by the occurrence of side effects can be reduced if proper measures are promptly adopted by the local, as well as by the global regulatory organizations. To this end, the main PV principles should be strictly followed by all the member countries of the WHO.
Dr. Md. Aktar Hossain, Assistant Director, Directorate General of Drug Administration (DGDA).
Mr. Ahmed Kamrul Alam, Director (Marketing), Square Pharmaceutical Industry Ltd., Dhaka, Bangladesh.
Ariful Karim, Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
The author declares no conflict of interest.
Special thank goes to my wife Shirotaz Begum for her cooperation to complete this write up.
Adverse Drug Reaction Adverse Drug Reaction Monitoring British Medical Journal Directorate General of Drug Administration Drug Regulatory Authorities Food and Drug Administration Individual Case Safety Reports International Drug Monitoring Global Patient Safety Challenge Public Health Programs Program for International Drug Monitoring Pharmacovigilance Uppsala Monitoring Center World Health Organization
As a company committed to the wider dissemination of knowledge, IntechOpen supports the OAI Metadata Harvesting Protocol (OAI-PMH Version 2.0).
',metaTitle:"OAI-PMH",metaDescription:"As a firm believer in the wider dissemination of knowledge, IntechOpen supports the OAI Metadata Harvesting Protocol (OAI-PMH Version 2.0).",metaKeywords:null,canonicalURL:"/page/oai-pmh",contentRaw:'[{"type":"htmlEditorComponent","content":"The OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting) is used to govern the collection of metadata descriptions and enables other archives to access our database. The Protocol has been developed by the Open Archives Initiative, based on ensuring interoperability standards in order to ease and promote broader and more efficient dissemination of information within the scientific community.
\\n\\nWe have adopted the Protocol to increase the number of readers of our publications. All our Works are more widely accessible, with resulting benefits for scholars, researchers, students, libraries, universities and other academic institutions. Through this method of exposing metadata, IntechOpen enables citation indexes, scientific search engines, scholarly databases, and scientific literature collections to gather metadata from our repository and make our publications available to a broader academic audience.
\\n\\nAs a Registered Data Provider, metadata for published Books and Chapters are available via our interface at the base URL: http://mts.intechopen.com/oai/index.php
\\n\\nREQUESTS
\\n\\nYou can find out more about the Protocol by visiting the Open Archives website. For additional questions please contact us at ai@intechopen.com.
\\n\\nDATABASES
\\n\\nDatabases, repositories and search engines that provide services based on metadata harvested using the OAI metadata harvesting protocol include:
\\n\\nBASE - Bielefeld Academic Search Engine
\\n\\nOne of the world's most powerful search engines, used primarily for academic Open Access web resources.
\\n\\n\\n\\nA search engine for online catalogues of publications from all over the world.
\\n"}]'},components:[{type:"htmlEditorComponent",content:'The OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting) is used to govern the collection of metadata descriptions and enables other archives to access our database. The Protocol has been developed by the Open Archives Initiative, based on ensuring interoperability standards in order to ease and promote broader and more efficient dissemination of information within the scientific community.
\n\nWe have adopted the Protocol to increase the number of readers of our publications. All our Works are more widely accessible, with resulting benefits for scholars, researchers, students, libraries, universities and other academic institutions. Through this method of exposing metadata, IntechOpen enables citation indexes, scientific search engines, scholarly databases, and scientific literature collections to gather metadata from our repository and make our publications available to a broader academic audience.
\n\nAs a Registered Data Provider, metadata for published Books and Chapters are available via our interface at the base URL: http://mts.intechopen.com/oai/index.php
\n\nREQUESTS
\n\nYou can find out more about the Protocol by visiting the Open Archives website. For additional questions please contact us at ai@intechopen.com.
\n\nDATABASES
\n\nDatabases, repositories and search engines that provide services based on metadata harvested using the OAI metadata harvesting protocol include:
\n\nBASE - Bielefeld Academic Search Engine
\n\nOne of the world's most powerful search engines, used primarily for academic Open Access web resources.
\n\n\n\nA search engine for online catalogues of publications from all over the world.
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{sort:"featured,name"},profiles:[],filtersByRegion:[],offset:0,limit:12,total:null},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish",topicId:"8,9,11,14,15,17,20,22,24"},books:[{type:"book",id:"11555",title:"Ubiquitous and Pervasive Computing - New Trends and Opportunities",subtitle:null,isOpenForSubmission:!0,hash:"42b6f15e5d9044c3abd00c231efec806",slug:null,bookSignature:"Prof. Rodrigo da Rosa Righi",coverURL:"https://cdn.intechopen.com/books/images_new/11555.jpg",editedByType:null,editors:[{id:"69889",title:"Prof.",name:"Rodrigo",surname:"da Rosa Righi",slug:"rodrigo-da-rosa-righi",fullName:"Rodrigo da Rosa Righi"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11551",title:"Blockchain",subtitle:null,isOpenForSubmission:!0,hash:"26f3d47bfbfd96e25e5b46001876cc48",slug:null,bookSignature:"Prof. Vardan Mkrttchian",coverURL:"https://cdn.intechopen.com/books/images_new/11551.jpg",editedByType:null,editors:[{id:"333134",title:"Prof.",name:"Vardan",surname:"Mkrttchian",slug:"vardan-mkrttchian",fullName:"Vardan Mkrttchian"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11458",title:"Human-Robot Interaction - Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"2003e3388833e911f610e0cd9788a5e7",slug:null,bookSignature:"Dr. Ramana Vinjamuri",coverURL:"https://cdn.intechopen.com/books/images_new/11458.jpg",editedByType:null,editors:[{id:"196746",title:"Dr.",name:"Ramana",surname:"Vinjamuri",slug:"ramana-vinjamuri",fullName:"Ramana Vinjamuri"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11506",title:"Antenna Arrays",subtitle:null,isOpenForSubmission:!0,hash:"1b378e33d6f6e73721ee0dacbbb89aa1",slug:null,bookSignature:"Prof. Hussain Al-Rizzo, Dr. Nijas Kunju and Dr. Aldebaro Klautau",coverURL:"https://cdn.intechopen.com/books/images_new/11506.jpg",editedByType:null,editors:[{id:"153384",title:"Prof.",name:"Hussain",surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11561",title:"Zeolite From Wastes - New Perspectives on Innovative Resources and Their Valorization Process",subtitle:null,isOpenForSubmission:!0,hash:"3ed0dfd842de9cd1143212415903e6ad",slug:null,bookSignature:"Dr. Claudia Belviso",coverURL:"https://cdn.intechopen.com/books/images_new/11561.jpg",editedByType:null,editors:[{id:"61457",title:"Dr.",name:"Claudia",surname:"Belviso",slug:"claudia-belviso",fullName:"Claudia Belviso"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11470",title:"Graphene - Recent Advances, Future Perspective and Applied Applications",subtitle:null,isOpenForSubmission:!0,hash:"409e022e3baf48795e816576a6ee66e3",slug:null,bookSignature:"Dr. Mujtaba Ikram, Dr. Asghari Maqsood and Dr. Aneeqa Bashir",coverURL:"https://cdn.intechopen.com/books/images_new/11470.jpg",editedByType:null,editors:[{id:"286820",title:"Dr.",name:"Mujtaba",surname:"Ikram",slug:"mujtaba-ikram",fullName:"Mujtaba Ikram"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11445",title:"Multi-Agent Technologies and Machine Learning",subtitle:null,isOpenForSubmission:!0,hash:"d980826615baa6e33456e2a79064c5e8",slug:null,bookSignature:"Prof. Igor Sheremet",coverURL:"https://cdn.intechopen.com/books/images_new/11445.jpg",editedByType:null,editors:[{id:"265237",title:"Prof.",name:"Igor",surname:"Sheremet",slug:"igor-sheremet",fullName:"Igor Sheremet"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11519",title:"Vibration Monitoring and Analysis - Recent Advances",subtitle:null,isOpenForSubmission:!0,hash:"f0d2d82a5c1a49020abf39dc8aabd89d",slug:null,bookSignature:"Dr.Ing. Louay Yousuf",coverURL:"https://cdn.intechopen.com/books/images_new/11519.jpg",editedByType:null,editors:[{id:"322417",title:"Dr.Ing.",name:"Louay",surname:"Yousuf",slug:"louay-yousuf",fullName:"Louay Yousuf"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11525",title:"Wood Industry - Past, Present and Future Outlook",subtitle:null,isOpenForSubmission:!0,hash:"ccb74142053c89e0e572ac1c5d717a11",slug:null,bookSignature:"Prof. Guanben Du and Dr. Xiaojian Zhou",coverURL:"https://cdn.intechopen.com/books/images_new/11525.jpg",editedByType:null,editors:[{id:"291315",title:"Prof.",name:"Guanben",surname:"Du",slug:"guanben-du",fullName:"Guanben Du"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11468",title:"High Entropy Alloys - Recent Advances, New Perspectives and Applications",subtitle:null,isOpenForSubmission:!0,hash:"3b4ef3ce01f8f9b113dc28ac847b8c0d",slug:null,bookSignature:"Prof. Yong A Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/11468.jpg",editedByType:null,editors:[{id:"203937",title:"Prof.",name:"Yong",surname:"Zhang",slug:"yong-zhang",fullName:"Yong Zhang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11484",title:"Thin Film Deposition - Fundamentals, Processes, and Applications",subtitle:null,isOpenForSubmission:!0,hash:"9c10a55203c2f0f7d47c743e6cfa2492",slug:null,bookSignature:"Dr. Dongfang Yang",coverURL:"https://cdn.intechopen.com/books/images_new/11484.jpg",editedByType:null,editors:[{id:"177814",title:"Dr.",name:"Dongfang",surname:"Yang",slug:"dongfang-yang",fullName:"Dongfang Yang"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11121",title:"Crystal Growth - Technologies and Applications",subtitle:null,isOpenForSubmission:!0,hash:"81f076fab2acb567946aeaa4b7281fc1",slug:null,bookSignature:"Dr. Riadh Marzouki",coverURL:"https://cdn.intechopen.com/books/images_new/11121.jpg",editedByType:null,editors:[{id:"300527",title:"Dr.",name:"Riadh",surname:"Marzouki",slug:"riadh-marzouki",fullName:"Riadh Marzouki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:43},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:11},{group:"topic",caption:"Business, Management and Economics",value:7,count:6},{group:"topic",caption:"Chemistry",value:8,count:23},{group:"topic",caption:"Computer and Information Science",value:9,count:21},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:17},{group:"topic",caption:"Engineering",value:11,count:59},{group:"topic",caption:"Environmental Sciences",value:12,count:9},{group:"topic",caption:"Immunology and Microbiology",value:13,count:10},{group:"topic",caption:"Materials Science",value:14,count:28},{group:"topic",caption:"Mathematics",value:15,count:10},{group:"topic",caption:"Medicine",value:16,count:122},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:9},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:12},{group:"topic",caption:"Psychology",value:21,count:10},{group:"topic",caption:"Robotics",value:22,count:4},{group:"topic",caption:"Social Sciences",value:23,count:8},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:4}],offset:12,limit:12,total:166},popularBooks:{featuredBooks:[],offset:0,limit:12,total:null},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"10584",title:"Engineered Wood Products for Construction",subtitle:null,isOpenForSubmission:!1,hash:"421757c56a3735986055250821275a51",slug:"engineered-wood-products-for-construction",bookSignature:"Meng Gong",coverURL:"https://cdn.intechopen.com/books/images_new/10584.jpg",publishedDate:"April 28th 2022",numberOfDownloads:3665,editors:[{id:"274242",title:"Dr.",name:"Meng",middleName:null,surname:"Gong",slug:"meng-gong",fullName:"Meng Gong"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10222",title:"Demyelination Disorders",subtitle:null,isOpenForSubmission:!1,hash:"b6c26ceccacdde70c41c587361bd5558",slug:"demyelination-disorders",bookSignature:"Stavros J. Baloyannis, Fabian H. Rossi and Welwin Liu",coverURL:"https://cdn.intechopen.com/books/images_new/10222.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1713,editors:[{id:"156098",title:"Emeritus Prof.",name:"Stavros J.",middleName:"J.",surname:"Baloyannis",slug:"stavros-j.-baloyannis",fullName:"Stavros J. Baloyannis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9544",title:"Global Trade in the Emerging Business Environment",subtitle:null,isOpenForSubmission:!1,hash:"fb8cb09b9599246add78d508a98273d5",slug:"global-trade-in-the-emerging-business-environment",bookSignature:"Muhammad Mohiuddin, Jingbin Wang , Md. Samim Al Azad and Selim Ahmed",coverURL:"https://cdn.intechopen.com/books/images_new/9544.jpg",publishedDate:"April 28th 2022",numberOfDownloads:2481,editors:[{id:"418514",title:"Dr.",name:"Muhammad",middleName:null,surname:"Mohiuddin",slug:"muhammad-mohiuddin",fullName:"Muhammad Mohiuddin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10979",title:"Parenting",subtitle:"Challenges of Child Rearing in a Changing Society",isOpenForSubmission:!1,hash:"6f345ebcf4fd61e73643c69063a12c7b",slug:"parenting-challenges-of-child-rearing-in-a-changing-society",bookSignature:"Sayyed Ali Samadi",coverURL:"https://cdn.intechopen.com/books/images_new/10979.jpg",publishedDate:"May 4th 2022",numberOfDownloads:1107,editors:[{id:"52145",title:"Dr.",name:"Sayyed Ali",middleName:null,surname:"Samadi",slug:"sayyed-ali-samadi",fullName:"Sayyed Ali Samadi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9808",title:"Contemporary Topics in Patient Safety",subtitle:"Volume 1",isOpenForSubmission:!1,hash:"fb6371607c2c6c02c6a2af8892765aba",slug:"contemporary-topics-in-patient-safety-volume-1",bookSignature:"Stanislaw P. Stawicki and Michael S. Firstenberg",coverURL:"https://cdn.intechopen.com/books/images_new/9808.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3307,editors:[{id:"181694",title:"Dr.",name:"Stanislaw P.",middleName:null,surname:"Stawicki",slug:"stanislaw-p.-stawicki",fullName:"Stanislaw P. Stawicki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10681",title:"Biodegradation Technology of Organic and Inorganic Pollutants",subtitle:null,isOpenForSubmission:!1,hash:"9a6e10e02788092872fd249436898e97",slug:"biodegradation-technology-of-organic-and-inorganic-pollutants",bookSignature:"Kassio Ferreira Mendes, Rodrigo Nogueira de Sousa and Kamila Cabral Mielke",coverURL:"https://cdn.intechopen.com/books/images_new/10681.jpg",publishedDate:"April 20th 2022",numberOfDownloads:3266,editors:[{id:"197720",title:"Ph.D.",name:"Kassio",middleName:null,surname:"Ferreira Mendes",slug:"kassio-ferreira-mendes",fullName:"Kassio Ferreira Mendes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10764",title:"Antenna Systems",subtitle:null,isOpenForSubmission:!1,hash:"2fbf1c7a5d92723f08198fc9b526a8ad",slug:"antenna-systems",bookSignature:"Hussain Al-Rizzo and Said Abushamleh",coverURL:"https://cdn.intechopen.com/books/images_new/10764.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1868,editors:[{id:"153384",title:"Prof.",name:"Hussain",middleName:null,surname:"Al-Rizzo",slug:"hussain-al-rizzo",fullName:"Hussain Al-Rizzo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10668",title:"Sustainability of Concrete With Synthetic and Recycled Aggregates",subtitle:null,isOpenForSubmission:!1,hash:"55856c6a8bc3a5b21dae5a1af09a56b6",slug:"sustainability-of-concrete-with-synthetic-and-recycled-aggregates",bookSignature:"Hosam M. Saleh",coverURL:"https://cdn.intechopen.com/books/images_new/10668.jpg",publishedDate:"May 4th 2022",numberOfDownloads:856,editors:[{id:"144691",title:"Prof.",name:"Hosam",middleName:null,surname:"Saleh",slug:"hosam-saleh",fullName:"Hosam Saleh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10803",title:"Reactive Oxygen Species",subtitle:null,isOpenForSubmission:!1,hash:"176adcf090fdd1f93cb8ce3146e79ca1",slug:"reactive-oxygen-species",bookSignature:"Rizwan Ahmad",coverURL:"https://cdn.intechopen.com/books/images_new/10803.jpg",publishedDate:"April 28th 2022",numberOfDownloads:1704,editors:[{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"9032",title:"Corporate Social Responsibility",subtitle:null,isOpenForSubmission:!1,hash:"f609bf3251d7cc7bae0099a4374adfc3",slug:"corporate-social-responsibility",bookSignature:"Beatrice Orlando",coverURL:"https://cdn.intechopen.com/books/images_new/9032.jpg",publishedDate:"March 16th 2022",numberOfDownloads:7489,editors:[{id:"232969",title:"Prof.",name:"Beatrice",middleName:null,surname:"Orlando",slug:"beatrice-orlando",fullName:"Beatrice Orlando"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10251",title:"Plankton Communities",subtitle:null,isOpenForSubmission:!1,hash:"e11e441ca2d2d5f631b1b4704505cfb6",slug:"plankton-communities",bookSignature:"Leonel Pereira and Ana Marta Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/10251.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10830",title:"Animal Feed Science and Nutrition",subtitle:"Production, Health and Environment",isOpenForSubmission:!1,hash:"79944fc8fbbaa329aed6fde388154832",slug:"animal-feed-science-and-nutrition-production-health-and-environment",bookSignature:"Amlan Kumar Patra",coverURL:"https://cdn.intechopen.com/books/images_new/10830.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10853",title:"Recent Advances in Polynomials",subtitle:null,isOpenForSubmission:!1,hash:"9e8671bae09ccaa8b8e276c639a737fc",slug:"recent-advances-in-polynomials",bookSignature:"Kamal Shah",coverURL:"https://cdn.intechopen.com/books/images_new/10853.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"231748",title:"Dr.",name:"Kamal",middleName:null,surname:"Shah",slug:"kamal-shah",fullName:"Kamal Shah"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10871",title:"Computed-Tomography (CT) Scan",subtitle:null,isOpenForSubmission:!1,hash:"966d8cf74fa27eea1b9cbc9a6ee94993",slug:"computed-tomography-ct-scan",bookSignature:"Reda R. Gharieb",coverURL:"https://cdn.intechopen.com/books/images_new/10871.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"225387",title:"Prof.",name:"Reda R.",middleName:"R.",surname:"Gharieb",slug:"reda-r.-gharieb",fullName:"Reda R. Gharieb"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10903",title:"Genetically Modified Plants and Beyond",subtitle:null,isOpenForSubmission:!1,hash:"4d7ed4faab99c92cd4d676dc86501df9",slug:"genetically-modified-plants-and-beyond",bookSignature:"Idah Sithole Niang",coverURL:"https://cdn.intechopen.com/books/images_new/10903.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"90172",title:"Prof.",name:"Idah",middleName:null,surname:"Sithole-Niang",slug:"idah-sithole-niang",fullName:"Idah Sithole-Niang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10904",title:"Fusarium",subtitle:"An Overview of the Genus",isOpenForSubmission:!1,hash:"49d9063e43f94bd1517d65fbc58b93c3",slug:"fusarium-an-overview-of-the-genus",bookSignature:"Seyed Mahyar Mirmajlessi",coverURL:"https://cdn.intechopen.com/books/images_new/10904.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"100573",title:"Dr.",name:"Seyed Mahyar",middleName:null,surname:"Mirmajlessi",slug:"seyed-mahyar-mirmajlessi",fullName:"Seyed Mahyar Mirmajlessi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,isOpenForSubmission:!1,hash:"a5308884068cc53ed31c6baba756857f",slug:"brain-computer-interface",bookSignature:"Vahid Asadpour",coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10676",title:"Recent Applications in Graph Theory",subtitle:null,isOpenForSubmission:!1,hash:"900c60742d224080732bd16bd25ccba8",slug:"recent-applications-in-graph-theory",bookSignature:"Harun Pirim",coverURL:"https://cdn.intechopen.com/books/images_new/10676.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"146092",title:"Dr.",name:"Harun",middleName:null,surname:"Pirim",slug:"harun-pirim",fullName:"Harun Pirim"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11196",title:"New Updates in E-Learning",subtitle:null,isOpenForSubmission:!1,hash:"6afaadf68e2a0a4b370ac5ceb5ca89c6",slug:"new-updates-in-e-learning",bookSignature:"Eduard Babulak",coverURL:"https://cdn.intechopen.com/books/images_new/11196.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"10086",title:"Prof.",name:"Eduard",middleName:null,surname:"Babulak",slug:"eduard-babulak",fullName:"Eduard Babulak"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9974",title:"E-Learning and Digital Education in the Twenty-First Century",subtitle:null,isOpenForSubmission:!1,hash:"88b58d66e975df20425fc1dfd22d53aa",slug:"e-learning-and-digital-education-in-the-twenty-first-century",bookSignature:"M. Mahruf C. Shohel",coverURL:"https://cdn.intechopen.com/books/images_new/9974.jpg",editedByType:"Edited by",publishedDate:"May 18th 2022",editors:[{id:"94099",title:"Dr.",name:"M. Mahruf C.",middleName:null,surname:"Shohel",slug:"m.-mahruf-c.-shohel",fullName:"M. Mahruf C. Shohel"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"921",title:"Electrostatics",slug:"ceramics-electrostatics",parent:{id:"155",title:"Ceramics",slug:"ceramics"},numberOfBooks:3,numberOfSeries:0,numberOfAuthorsAndEditors:86,numberOfWosCitations:121,numberOfCrossrefCitations:58,numberOfDimensionsCitations:118,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"921",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"5215",title:"Piezoelectric Materials",subtitle:null,isOpenForSubmission:!1,hash:"a062db03e5e21b64942d5d4dfd9b7bd2",slug:"piezoelectric-materials",bookSignature:"Toshio Ogawa",coverURL:"https://cdn.intechopen.com/books/images_new/5215.jpg",editedByType:"Edited by",editors:[{id:"33684",title:"Prof.",name:"Toshio",middleName:null,surname:"Ogawa",slug:"toshio-ogawa",fullName:"Toshio Ogawa"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3272",title:"Piezoelectric Materials and Devices",subtitle:"Practice and Applications",isOpenForSubmission:!1,hash:"a41c5bb092cc30980df760d6bec44c20",slug:"piezoelectric-materials-and-devices-practice-and-applications",bookSignature:"Farzad Ebrahimi",coverURL:"https://cdn.intechopen.com/books/images_new/3272.jpg",editedByType:"Edited by",editors:[{id:"20062",title:"Dr.",name:"Farzad",middleName:null,surname:"Ebrahimi",slug:"farzad-ebrahimi",fullName:"Farzad Ebrahimi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3218",title:"Piezoelectric Ceramics",subtitle:null,isOpenForSubmission:!1,hash:"835cbf1fbf213fbd3aeb4e4cbf1686c9",slug:"piezoelectric-ceramics",bookSignature:"Ernesto Suaste-Gomez",coverURL:"https://cdn.intechopen.com/books/images_new/3218.jpg",editedByType:"Edited by",editors:[{id:"12814",title:"Dr.",name:"Ernesto",middleName:null,surname:"Suaste-Gomez",slug:"ernesto-suaste-gomez",fullName:"Ernesto Suaste-Gomez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:3,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"11644",doi:"10.5772/9942",title:"Porous Piezoelectric Ceramics",slug:"porous-piezoelectric-ceramics",totalDownloads:5427,totalCrossrefCites:14,totalDimensionsCites:30,abstract:null,book:{id:"3218",slug:"piezoelectric-ceramics",title:"Piezoelectric Ceramics",fullTitle:"Piezoelectric Ceramics"},signatures:"Elisa Mercadelli, Alessandra Sanson and Carmen Galassi",authors:[{id:"12866",title:"Dr.",name:"Elisa",middleName:null,surname:"Mercadelli",slug:"elisa-mercadelli",fullName:"Elisa Mercadelli"},{id:"12886",title:"Dr.",name:"Alessandra",middleName:null,surname:"Sanson",slug:"alessandra-sanson",fullName:"Alessandra Sanson"},{id:"12887",title:"Dr.",name:"Carmen",middleName:null,surname:"Galassi",slug:"carmen-galassi",fullName:"Carmen Galassi"}]},{id:"11647",doi:"10.5772/9945",title:"Piezoelectric Material-Based Energy Harvesting Devices: Advance of SSH Optimization Techniques (1999-2009)",slug:"piezoelectric-material-based-energy-harvesting-devices-advance-of-ssh-optimization-techniques-1999-2",totalDownloads:3616,totalCrossrefCites:5,totalDimensionsCites:12,abstract:null,book:{id:"3218",slug:"piezoelectric-ceramics",title:"Piezoelectric Ceramics",fullTitle:"Piezoelectric Ceramics"},signatures:"Elie Lefeuvre, Mickail Lallart, Claude Richard and Daniel Guyomar",authors:[{id:"10041",title:"Dr.",name:"Mickaël",middleName:null,surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"},{id:"10042",title:"Prof.",name:"Daniel",middleName:"Jean",surname:"Guyomar",slug:"daniel-guyomar",fullName:"Daniel Guyomar"},{id:"12121",title:"Dr.",name:"Elie",middleName:null,surname:"Lefeuvre",slug:"elie-lefeuvre",fullName:"Elie Lefeuvre"},{id:"12927",title:"Pr",name:"Claude",middleName:null,surname:"Richard",slug:"claude-richard",fullName:"Claude Richard"}]},{id:"40134",doi:"10.5772/53117",title:"Acoustic Wave Velocity Measurement on Piezoelectric Ceramics",slug:"acoustic-wave-velocity-measurement-on-piezoelectric-ceramics",totalDownloads:3535,totalCrossrefCites:6,totalDimensionsCites:10,abstract:null,book:{id:"3272",slug:"piezoelectric-materials-and-devices-practice-and-applications",title:"Piezoelectric Materials and Devices",fullTitle:"Piezoelectric Materials and Devices - Practice and Applications"},signatures:"Toshio Ogawa",authors:[{id:"33684",title:"Prof.",name:"Toshio",middleName:null,surname:"Ogawa",slug:"toshio-ogawa",fullName:"Toshio Ogawa"}]},{id:"11646",doi:"10.5772/9944",title:"Lead-Free Piezoelectric Transducers for Microelectronic Wirebonding Applications",slug:"lead-free-piezoelectric-transducers-for-microelectronic-wirebonding-applications-",totalDownloads:4906,totalCrossrefCites:5,totalDimensionsCites:9,abstract:null,book:{id:"3218",slug:"piezoelectric-ceramics",title:"Piezoelectric Ceramics",fullTitle:"Piezoelectric Ceramics"},signatures:"K.W. Kwok, T. Lee, S.H. Choy and H.L.W. Chan",authors:[{id:"12889",title:"Dr.",name:"K.W.",middleName:null,surname:"Kwok",slug:"k.w.-kwok",fullName:"K.W. Kwok"},{id:"12891",title:"Prof.",name:"H.L.W.",middleName:null,surname:"Chan",slug:"h.l.w.-chan",fullName:"H.L.W. Chan"}]},{id:"50639",doi:"10.5772/62630",title:"Piezoelectric-Layered Structures Based on Synthetic Diamond",slug:"piezoelectric-layered-structures-based-on-synthetic-diamond",totalDownloads:1194,totalCrossrefCites:6,totalDimensionsCites:8,abstract:"Results of theoretical, modeling, and experimental investigation of microwave acoustic properties of piezoelectric layered structure “Me1/AlN/Me2/(100) diamond” have been presented within a wide frequency band 0.5–10 GHz. The highest among known material quality parameter Q × f ~ 1014 Hz for the IIa type synthetic diamond at operational frequency ~10 GHz has been found. Conditions of UHF excitation and propagation of the bulk, surface, and Lamb plate acoustic waves have been established and studied experimentally. Frequency dependencies of the impedance and quality factor have been studied to obtain a number of piezoelectric layered structure parameters as electromechanical coupling coefficient, equivalent circuit parameters, etc. Results of 2D finite element modeling of a given piezoelectric layered structure have been compared with the experimental ones obtained for the real high-overtone bulk acoustic resonator. An origin of high-overtone bulk acoustic resonator’s spurious resonant peaks has been studied. Results on UHF acoustic attenuation of IIa-type synthetic single crystalline diamond have been presented and discussed in terms of Akhiezer and Landau–Rumer mechanisms of phonon–phonon interaction. Identification and classification of Lamb waves belonging to several branches as well as dispersive curves of phase velocities have been executed. Necessity of introducing a more correct Lamb-mode classification has been recognized.",book:{id:"5215",slug:"piezoelectric-materials",title:"Piezoelectric Materials",fullTitle:"Piezoelectric Materials"},signatures:"Boris P. Sorokin, Gennady M. Kvashnin, Arsenii V. Telichko, Sergey I. Burkov and Vladimir D. Blank",authors:[{id:"181306",title:"Prof.",name:"Boris",middleName:null,surname:"Sorokin",slug:"boris-sorokin",fullName:"Boris Sorokin"},{id:"185347",title:"Dr.",name:"Gennadiy",middleName:null,surname:"Kvashnin",slug:"gennadiy-kvashnin",fullName:"Gennadiy Kvashnin"},{id:"185348",title:"Dr.",name:"Arsenii",middleName:null,surname:"Telichko",slug:"arsenii-telichko",fullName:"Arsenii Telichko"},{id:"185349",title:"Dr.",name:"Sergey",middleName:null,surname:"Burkov",slug:"sergey-burkov",fullName:"Sergey Burkov"},{id:"185350",title:"Prof.",name:"Vladimir",middleName:null,surname:"Blank",slug:"vladimir-blank",fullName:"Vladimir Blank"}]}],mostDownloadedChaptersLast30Days:[{id:"51560",title:"Piezoelectric Energy Harvesting",slug:"piezoelectric-energy-harvesting",totalDownloads:2912,totalCrossrefCites:3,totalDimensionsCites:6,abstract:"The piezoelectric material selection and the circuit design in vibrational energy harvesting are discussed. The performances of the energy-harvesting unimorph devices that captured frequencies of 60 Hz by using piezoelectric PZT-based and BT-based ceramics were evaluated. Output voltages and power from the devices depend on the amplitude and the frequency of the oscillations, and depend on the load resistance. Generally, PZT-based ceramics are superior for piezoelectric energy-harvesting applications. The figures of merit of the materials are discussed in order to provide the guidelines of the piezoelectric material selections. Piezoelectric voltage coefficient, g31, is considered to be good parameter to predict the maximum voltages. On the other hand, d31g31/tanδ, k312Qm and d31g31 are close to the behavior of the maximum power. Combination of the piezoelectric unimorph and power management circuit produced the constant voltage output, which would be used as the power sources.",book:{id:"5215",slug:"piezoelectric-materials",title:"Piezoelectric Materials",fullTitle:"Piezoelectric Materials"},signatures:"Hiroshi Maiwa",authors:[{id:"27242",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Maiwa",slug:"hiroshi-maiwa",fullName:"Hiroshi Maiwa"}]},{id:"43265",title:"The Application of Piezoelectric Materials in Machining Processes",slug:"the-application-of-piezoelectric-materials-in-machining-processes",totalDownloads:4528,totalCrossrefCites:0,totalDimensionsCites:0,abstract:null,book:{id:"3272",slug:"piezoelectric-materials-and-devices-practice-and-applications",title:"Piezoelectric Materials and Devices",fullTitle:"Piezoelectric Materials and Devices - Practice and Applications"},signatures:"Saeed Assarzadeh and Majid Ghoreishi",authors:[{id:"162546",title:"Dr.",name:"Saeed",middleName:null,surname:"Assarzadeh",slug:"saeed-assarzadeh",fullName:"Saeed Assarzadeh"}]},{id:"50322",title:"Acoustic Wave Velocity Measurement on Piezoelectric Single Crystals",slug:"acoustic-wave-velocity-measurement-on-piezoelectric-single-crystals",totalDownloads:1821,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Sound velocities were measured in relaxor single-crystal plates and piezoelectric ceramics including lead free using an ultrasonic precision thickness gauge with high-frequency pulse generation. Estimating the difference in the sound velocities and elastic constants in the single crystals and ceramics, it was possible to evaluate effects of domain and grain boundaries on elastic constants. Existence of domain boundaries in single crystal affected the decrease in Young’s modulus, rigidity, Poisson’s ratio, and bulk modulus. While existence of grain boundaries affected the decrease in Young’s modulus and rigidity, Poisson’s ratio and bulk modulus increased. It was thought these phenomena come from domain alignment by DC poling and both the boundaries act as to absorb mechanical stress by defects due to the boundaries. In addition, the origin of piezoelectricity in single crystals is caused by low bulk modulus and Poisson’s ratio, and high Young’s modulus and rigidity in comparison with ceramics. On the contrary, the origin of piezoelectricity in ceramics is caused by high Poisson’s ratio by high bulk modulus, and furthermore, low Young’s modulus and rigidity due to domain alignment.",book:{id:"5215",slug:"piezoelectric-materials",title:"Piezoelectric Materials",fullTitle:"Piezoelectric Materials"},signatures:"Toshio Ogawa",authors:[{id:"33684",title:"Prof.",name:"Toshio",middleName:null,surname:"Ogawa",slug:"toshio-ogawa",fullName:"Toshio Ogawa"}]},{id:"50728",title:"Piezoelectric Materials in RF Applications",slug:"piezoelectric-materials-in-rf-applications",totalDownloads:2148,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"The development of several types of mobile objects requires new devices, such as high‐performance filters, microelectromechanical systems and other components. Piezoelectric materials are crucial to reach the expected performance of mobile objects because they exhibit high quality factors and sharp resonance and some of them are compatible with collective manufacturing technologies. We reviewed the main piezoelectric materials that can be used for radio frequency (RF) applications and herein report data on some devices. The modelling of piezoelectric plates and structures in the context of electronic circuits is presented. Among RF devices, filters are the most critical as the piezoelectric material must operate at RF frequencies. The main filter structures and characterisation methods, in accordance with such operating conditions as high frequencies and high power, are also discussed.",book:{id:"5215",slug:"piezoelectric-materials",title:"Piezoelectric Materials",fullTitle:"Piezoelectric Materials"},signatures:"Philippe Benech and Jean‐Marc Duchamp",authors:[{id:"4490",title:"Dr.",name:"Philippe",middleName:null,surname:"Benech",slug:"philippe-benech",fullName:"Philippe Benech"},{id:"182052",title:"Dr.",name:"Jean-Marc",middleName:null,surname:"Duchamp",slug:"jean-marc-duchamp",fullName:"Jean-Marc Duchamp"}]},{id:"11639",title:"Piezoelectric Thin Film Deposition: Novel Self-Assembled Island Structures and Low Temperature Processes on Silicon",slug:"piezoelectric-thin-film-deposition-novel-self-assembled-island-structures-and-low-temperature-proces",totalDownloads:4049,totalCrossrefCites:1,totalDimensionsCites:1,abstract:null,book:{id:"3218",slug:"piezoelectric-ceramics",title:"Piezoelectric Ceramics",fullTitle:"Piezoelectric Ceramics"},signatures:"Sharath Sriram, Madhu Bhaskaran and Arnan Mitchell",authors:[{id:"12171",title:"Dr.",name:"Sharath",middleName:null,surname:"Sriram",slug:"sharath-sriram",fullName:"Sharath Sriram"},{id:"12172",title:"Dr.",name:"Madhu",middleName:null,surname:"Bhaskaran",slug:"madhu-bhaskaran",fullName:"Madhu Bhaskaran"},{id:"12173",title:"Prof",name:"Arnan",middleName:null,surname:"Mitchell",slug:"arnan-mitchell",fullName:"Arnan Mitchell"}]}],onlineFirstChaptersFilter:{topicId:"921",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:98,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:287,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:10,numberOfPublishedChapters:103,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261",scope:"Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the cooperation between structure and function at the cellular and molecular levels governed by gene and protein expression. While a daunting task, learning is facilitated by identifying common and effective signaling pathways mediated by a variety of factors employed by nature to preserve and sustain homeostatic life. \r\nAs a leading example, the cellular interaction between intracellular concentration of Ca+2 increases, and changes in plasma membrane potential is integral for coordinating blood flow, governing the exocytosis of neurotransmitters, and modulating gene expression and cell effector secretory functions. Furthermore, in this manner, understanding the systemic interaction between the cardiovascular and nervous systems has become more important than ever as human populations' life prolongation, aging and mechanisms of cellular oxidative signaling are utilised for sustaining life. \r\nAltogether, physiological research enables our identification of distinct and precise points of transition from health to the development of multimorbidity throughout the inevitable aging disorders (e.g., diabetes, hypertension, chronic kidney disease, heart failure, peptic ulcer, inflammatory bowel disease, age-related macular degeneration, cancer). With consideration of all organ systems (e.g., brain, heart, lung, gut, skeletal and smooth muscle, liver, pancreas, kidney, eye) and the interactions thereof, this Physiology Series will address the goals of resolving (1) Aging physiology and chronic disease progression (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling, and (3) how changes in plasma membrane produced by lipid peroxidation products can affect aging physiology, covering new research in the area of cell, human, plant and animal physiology.",coverUrl:"https://cdn.intechopen.com/series/covers/10.jpg",latestPublicationDate:"May 14th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:11,editor:{id:"35854",title:"Prof.",name:"Tomasz",middleName:null,surname:"Brzozowski",slug:"tomasz-brzozowski",fullName:"Tomasz Brzozowski",profilePictureURL:"https://mts.intechopen.com/storage/users/35854/images/system/35854.jpg",biography:"Prof. Dr. Thomas Brzozowski works as a professor of Human Physiology and is currently Chairman at the Department of Physiology and is V-Dean of the Medical Faculty at Jagiellonian University Medical College, Cracow, Poland. His primary area of interest is physiology and pathophysiology of the gastrointestinal (GI) tract, with the major focus on the mechanism of GI mucosal defense, protection, and ulcer healing. He was a postdoctoral NIH fellow at the University of California and the Gastroenterology VA Medical Center, Irvine, Long Beach, CA, USA, and at the Gastroenterology Clinics Erlangen-Nuremberg and Munster in Germany. He has published 290 original articles in some of the most prestigious scientific journals and seven book chapters on the pathophysiology of the GI tract, gastroprotection, ulcer healing, drug therapy of peptic ulcers, hormonal regulation of the gut, and inflammatory bowel disease.",institutionString:null,institution:{name:"Jagiellonian University",institutionURL:null,country:{name:"Poland"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"10",title:"Animal Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",isOpenForSubmission:!0,annualVolume:11406,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"11",title:"Cell Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/11.jpg",isOpenForSubmission:!0,annualVolume:11407,editor:{id:"133493",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",profilePictureURL:"https://mts.intechopen.com/storage/users/133493/images/3091_n.jpg",biography:"Prof. Dr. Angel Catalá \r\nShort Biography Angel Catalá was born in Rodeo (San Juan, Argentina). He studied \r\nchemistry at the Universidad Nacional de La Plata, Argentina, where received aPh.D. degree in chemistry (Biological Branch) in 1965. From\r\n1964 to 1974, he worked as Assistant in Biochemistry at the School of MedicineUniversidad Nacional de La Plata, Argentina. From 1974 to 1976, he was a Fellowof the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor oBiochemistry at the Universidad Nacional de La Plata, Argentina. He is Member ofthe National Research Council (CONICET), Argentina, and Argentine Society foBiochemistry and Molecular Biology (SAIB). His laboratory has been interested for manyears in the lipid peroxidation of biological membranes from various tissues and different species. Professor Catalá has directed twelve doctoral theses, publishedover 100 papers in peer reviewed journals, several chapters in books andtwelve edited books. Angel Catalá received awards at the 40th InternationaConference Biochemistry of Lipids 1999: Dijon (France). W inner of the Bimbo PanAmerican Nutrition, Food Science and Technology Award 2006 and 2012, South AmericaHuman Nutrition, Professional Category. 2006 award in pharmacology, Bernardo\r\nHoussay, in recognition of his meritorious works of research. Angel Catalá belongto the Editorial Board of Journal of lipids, International Review of Biophysical ChemistryFrontiers in Membrane Physiology and Biophysics, World Journal oExperimental Medicine and Biochemistry Research International, W orld Journal oBiological Chemistry, Oxidative Medicine and Cellular Longevity, Diabetes and thePancreas, International Journal of Chronic Diseases & Therapy, International Journal oNutrition, Co-Editor of The Open Biology Journal.",institutionString:null,institution:{name:"National University of La Plata",institutionURL:null,country:{name:"Argentina"}}},editorTwo:null,editorThree:null},{id:"12",title:"Human Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",isOpenForSubmission:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}}},{id:"13",title:"Plant Physiology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/13.jpg",isOpenForSubmission:!0,annualVolume:11409,editor:{id:"332229",title:"Prof.",name:"Jen-Tsung",middleName:null,surname:"Chen",slug:"jen-tsung-chen",fullName:"Jen-Tsung Chen",profilePictureURL:"https://mts.intechopen.com/storage/users/332229/images/system/332229.png",biography:"Dr. Jen-Tsung Chen is currently a professor at the National University of Kaohsiung, Taiwan. He teaches cell biology, genomics, proteomics, medicinal plant biotechnology, and plant tissue culture. Dr. Chen\\'s research interests include bioactive compounds, chromatography techniques, in vitro culture, medicinal plants, phytochemicals, and plant biotechnology. He has published more than ninety scientific papers and serves as an editorial board member for Plant Methods, Biomolecules, and International Journal of Molecular Sciences.",institutionString:"National University of Kaohsiung",institution:{name:"National University of Kaohsiung",institutionURL:null,country:{name:"Taiwan"}}},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:17,paginationItems:[{id:"81751",title:"NanoBioSensors: From Electrochemical Sensors Improvement to Theranostic Applications",doi:"10.5772/intechopen.102552",signatures:"Anielle C.A. Silva, Eliete A. Alvin, Lais S. de Jesus, Caio C.L. de França, Marílya P.G. da Silva, Samaysa L. Lins, Diógenes Meneses, Marcela R. Lemes, Rhanoica O. Guerra, Marcos V. da Silva, Carlo J.F. de Oliveira, Virmondes Rodrigues Junior, Renata M. Etchebehere, Fabiane C. de Abreu, Bruno G. Lucca, Sanívia A.L. Pereira, Rodrigo C. Rosa and Noelio O. Dantas",slug:"nanobiosensors-from-electrochemical-sensors-improvement-to-theranostic-applications",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81766",title:"Evolution of Organoids in Oncology",doi:"10.5772/intechopen.104251",signatures:"Allen Thayakumar Basanthakumar, Janitha Chandrasekhar Darlybai and Jyothsna Ganesh",slug:"evolution-of-organoids-in-oncology",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}},{id:"81678",title:"Developmental Studies on Practical Enzymatic Phosphate Ion Biosensors and Microbial BOD Biosensors, and New Insights into the Future Perspectives of These Biosensor Fields",doi:"10.5772/intechopen.104377",signatures:"Hideaki Nakamura",slug:"developmental-studies-on-practical-enzymatic-phosphate-ion-biosensors-and-microbial-bod-biosensors-a",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hideaki",surname:"Nakamura"}],book:{title:"Biosignal Processing",coverURL:"https://cdn.intechopen.com/books/images_new/11153.jpg",subseries:{id:"7",title:"Bioinformatics and Medical Informatics"}}},{id:"81547",title:"Organoids and Commercialization",doi:"10.5772/intechopen.104706",signatures:"Anubhab Mukherjee, Aprajita Sinha, Maheshree Maibam, Bharti Bisht and Manash K. Paul",slug:"organoids-and-commercialization",totalDownloads:30,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Organoids",coverURL:"https://cdn.intechopen.com/books/images_new/11430.jpg",subseries:null}}]},overviewPagePublishedBooks:{paginationCount:12,paginationItems:[{type:"book",id:"6692",title:"Medical and Biological Image Analysis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6692.jpg",slug:"medical-and-biological-image-analysis",publishedDate:"July 4th 2018",editedByType:"Edited by",bookSignature:"Robert Koprowski",hash:"e75f234a0fc1988d9816a94e4c724deb",volumeInSeries:1,fullTitle:"Medical and Biological Image Analysis",editors:[{id:"50150",title:"Prof.",name:"Robert",middleName:null,surname:"Koprowski",slug:"robert-koprowski",fullName:"Robert Koprowski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTYNQA4/Profile_Picture_1630478535317",biography:"Robert Koprowski, MD (1997), PhD (2003), Habilitation (2015), is an employee of the University of Silesia, Poland, Institute of Computer Science, Department of Biomedical Computer Systems. For 20 years, he has studied the analysis and processing of biomedical images, emphasizing the full automation of measurement for a large inter-individual variability of patients. Dr. Koprowski has authored more than a hundred research papers with dozens in impact factor (IF) journals and has authored or co-authored six books. Additionally, he is the author of several national and international patents in the field of biomedical devices and imaging. Since 2011, he has been a reviewer of grants and projects (including EU projects) in biomedical engineering.",institutionString:null,institution:{name:"University of Silesia",institutionURL:null,country:{name:"Poland"}}}]},{type:"book",id:"7218",title:"OCT",subtitle:"Applications in Ophthalmology",coverURL:"https://cdn.intechopen.com/books/images_new/7218.jpg",slug:"oct-applications-in-ophthalmology",publishedDate:"September 19th 2018",editedByType:"Edited by",bookSignature:"Michele Lanza",hash:"e3a3430cdfd6999caccac933e4613885",volumeInSeries:2,fullTitle:"OCT - Applications in Ophthalmology",editors:[{id:"240088",title:"Prof.",name:"Michele",middleName:null,surname:"Lanza",slug:"michele-lanza",fullName:"Michele Lanza",profilePictureURL:"https://mts.intechopen.com/storage/users/240088/images/system/240088.png",biography:"Michele Lanza is Associate Professor of Ophthalmology at Università della Campania, Luigi Vanvitelli, Napoli, Italy. His fields of interest are anterior segment disease, keratoconus, glaucoma, corneal dystrophies, and cataracts. His research topics include\nintraocular lens power calculation, eye modification induced by refractive surgery, glaucoma progression, and validation of new diagnostic devices in ophthalmology. \nHe has published more than 100 papers in international and Italian scientific journals, more than 60 in journals with impact factors, and chapters in international and Italian books. He has also edited two international books and authored more than 150 communications or posters for the most important international and Italian ophthalmology conferences.",institutionString:'University of Campania "Luigi Vanvitelli"',institution:{name:'University of Campania "Luigi Vanvitelli"',institutionURL:null,country:{name:"Italy"}}}]},{type:"book",id:"7560",title:"Non-Invasive Diagnostic Methods",subtitle:"Image Processing",coverURL:"https://cdn.intechopen.com/books/images_new/7560.jpg",slug:"non-invasive-diagnostic-methods-image-processing",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Mariusz Marzec and Robert Koprowski",hash:"d92fd8cf5a90a47f2b8a310837a5600e",volumeInSeries:3,fullTitle:"Non-Invasive Diagnostic Methods - Image Processing",editors:[{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null}]},{type:"book",id:"6843",title:"Biomechanics",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6843.jpg",slug:"biomechanics",publishedDate:"January 30th 2019",editedByType:"Edited by",bookSignature:"Hadi Mohammadi",hash:"85132976010be1d7f3dbd88662b785e5",volumeInSeries:4,fullTitle:"Biomechanics",editors:[{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",institutionURL:null,country:{name:"Canada"}}}]}]},openForSubmissionBooks:{paginationCount:3,paginationItems:[{id:"11675",title:"Advances in Skeletal Muscle Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11675.jpg",hash:"e1d9662c334dd78ab35bfb57c3bf106e",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"April 19th 2022",isOpenForSubmission:!0,editors:[{id:"281317",title:"Dr.",name:"Fabio",surname:"Iannotti",slug:"fabio-iannotti",fullName:"Fabio Iannotti"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11677",title:"New Insights in Mammalian Endocrinology",coverURL:"https://cdn.intechopen.com/books/images_new/11677.jpg",hash:"c59dd0f87bbf829ca091c485f4cc4e68",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"May 5th 2022",isOpenForSubmission:!0,editors:[{id:"321396",title:"Prof.",name:"Muhammad Subhan",surname:"Qureshi",slug:"muhammad-subhan-qureshi",fullName:"Muhammad Subhan Qureshi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11676",title:"Recent Advances in Homeostasis",coverURL:"https://cdn.intechopen.com/books/images_new/11676.jpg",hash:"63eb775115bf2d6d88530b234a1cc4c2",secondStepPassed:!1,currentStepOfPublishingProcess:2,submissionDeadline:"June 10th 2022",isOpenForSubmission:!0,editors:[{id:"203015",title:"Dr.",name:"Gaffar",surname:"Zaman",slug:"gaffar-zaman",fullName:"Gaffar Zaman"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{},subseriesFiltersForOFChapters:[],publishedBooks:{},subseriesFiltersForPublishedBooks:[],publicationYearFilters:[],authors:{}},subseries:{item:{id:"26",type:"subseries",title:"Machine Learning and Data Mining",keywords:"Intelligent Systems, Machine Learning, Data Science, Data Mining, Artificial Intelligence",scope:"The scope of machine learning and data mining is immense and is growing every day. It has become a massive part of our daily lives, making predictions based on experience, making this a fascinating area that solves problems that otherwise would not be possible or easy to solve. This topic aims to encompass algorithms that learn from experience (supervised and unsupervised), improve their performance over time and enable machines to make data-driven decisions. It is not limited to any particular applications, but contributions are encouraged from all disciplines.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/26.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11422,editor:{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",biography:"Dr. Marco Antonio Aceves Fernandez obtained his B.Sc. (Eng.) in Telematics from the Universidad de Colima, Mexico. He obtained both his M.Sc. and Ph.D. from the University of Liverpool, England, in the field of Intelligent Systems. He is a full professor at the Universidad Autonoma de Queretaro, Mexico, and a member of the National System of Researchers (SNI) since 2009. Dr. Aceves Fernandez has published more than 80 research papers as well as a number of book chapters and congress papers. He has contributed in more than 20 funded research projects, both academic and industrial, in the area of artificial intelligence, ranging from environmental, biomedical, automotive, aviation, consumer, and robotics to other applications. He is also a honorary president at the National Association of Embedded Systems (AMESE), a senior member of the IEEE, and a board member of many institutions. His research interests include intelligent and embedded systems.",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,series:{id:"14",title:"Artificial Intelligence",doi:"10.5772/intechopen.79920",issn:"2633-1403"},editorialBoard:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",slug:"ciza-thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}},{id:"16614",title:"Prof.",name:"Juan Ignacio",middleName:null,surname:"Guerrero Alonso",slug:"juan-ignacio-guerrero-alonso",fullName:"Juan Ignacio Guerrero Alonso",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6HB8QAM/Profile_Picture_1627901127555",institutionString:null,institution:{name:"University of Seville",institutionURL:null,country:{name:"Spain"}}},{id:"3095",title:"Prof.",name:"Kenji",middleName:null,surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/3095/images/1592_n.jpg",institutionString:null,institution:{name:"University of Chicago",institutionURL:null,country:{name:"United States of America"}}},{id:"214067",title:"Dr.",name:"W. David",middleName:null,surname:"Pan",slug:"w.-david-pan",fullName:"W. David Pan",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSEI9QAO/Profile_Picture_1623656213532",institutionString:null,institution:{name:"University of Alabama in Huntsville",institutionURL:null,country:{name:"United States of America"}}},{id:"72920",title:"Prof.",name:"Yves",middleName:"Philippe",surname:"Rybarczyk",slug:"yves-rybarczyk",fullName:"Yves Rybarczyk",profilePictureURL:"https://mts.intechopen.com/storage/users/72920/images/system/72920.jpeg",institutionString:"Dalarna University, Faculty of Data and Information Sciences",institution:{name:"Dalarna University",institutionURL:null,country:{name:"Sweden"}}}]},onlineFirstChapters:{paginationCount:13,paginationItems:[{id:"81566",title:"New and Emerging Technologies for Integrative Ambulatory Autonomic Assessment and Intervention as a Catalyst in the Synergy of Remote Geocoded Biosensing, Algorithmic Networked Cloud Computing, Deep Learning, and Regenerative/Biomic Medicine: Further Real",doi:"10.5772/intechopen.104092",signatures:"Robert L. Drury",slug:"new-and-emerging-technologies-for-integrative-ambulatory-autonomic-assessment-and-intervention-as-a-",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"81286",title:"Potassium Derangements: A Pathophysiological Review, Diagnostic Approach, and Clinical Management",doi:"10.5772/intechopen.103016",signatures:"Sairah Sharif and Jie Tang",slug:"potassium-derangements-a-pathophysiological-review-diagnostic-approach-and-clinical-management",totalDownloads:24,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80895",title:"Heart Rate Variability as a Marker of Homeostatic Level",doi:"10.5772/intechopen.102500",signatures:"Moacir Fernandes de Godoy and Michele Lima Gregório",slug:"heart-rate-variability-as-a-marker-of-homeostatic-level",totalDownloads:25,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Moacir",surname:"Godoy"},{name:"Michele",surname:"Gregório"}],book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80433",title:"Heart Autonomic Nervous System: Basic Science and Clinical Implications",doi:"10.5772/intechopen.101718",signatures:"Elvan Wiyarta and Nayla Karima",slug:"heart-autonomic-nervous-system-basic-science-and-clinical-implications",totalDownloads:49,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80316",title:"Central Control of the Larynx in Mammals",doi:"10.5772/intechopen.102009",signatures:"Manuel Víctor López-González, Marta González-García, Laura Carrillo-Franco, Amelia Díaz-Casares and Marc Stefan Dawid-Milner",slug:"central-control-of-the-larynx-in-mammals",totalDownloads:36,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80402",title:"General Anesthesia and Autonomic Nervous System: Control and Management in Neurosurgery",doi:"10.5772/intechopen.101829",signatures:"Irina Alexandrovna Savvina, Anna Olegovna Petrova and Yulia Mikhailovna Zabrodskaya",slug:"general-anesthesia-and-autonomic-nervous-system-control-and-management-in-neurosurgery",totalDownloads:58,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80035",title:"Healthy Lifestyle, Autonomic Nervous System Activity, and Sleep Status for Healthy Aging",doi:"10.5772/intechopen.101837",signatures:"Miki Sato, Feni Betriana, Ryuichi Tanioka, Kyoko Osaka, Tetsuya Tanioka and Savina Schoenhofer",slug:"healthy-lifestyle-autonomic-nervous-system-activity-and-sleep-status-for-healthy-aging",totalDownloads:60,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80175",title:"Signaling Pathways Regulating Axogenesis and Dendritogenesis in Sympathetic Neurons",doi:"10.5772/intechopen.102442",signatures:"Vidya Chandrasekaran",slug:"signaling-pathways-regulating-axogenesis-and-dendritogenesis-in-sympathetic-neurons",totalDownloads:66,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Vidya",surname:"Chandrasekaran"}],book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"80176",title:"Impacts of Environmental Stressors on Autonomic Nervous System",doi:"10.5772/intechopen.101842",signatures:"Mayowa Adeniyi",slug:"impacts-of-environmental-stressors-on-autonomic-nervous-system",totalDownloads:66,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"79655",title:"The Autonomic Nervous System, Sex Differences, and Chronobiology under General Anesthesia in In Vivo Experiments Involving Rats",doi:"10.5772/intechopen.101075",signatures:"Pavol Svorc Jr and Pavol Svorc",slug:"the-autonomic-nervous-system-sex-differences-and-chronobiology-under-general-anesthesia-in-in-vivo-e",totalDownloads:91,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Autonomic Nervous System - Special Interest Topics",coverURL:"https://cdn.intechopen.com/books/images_new/10835.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"79194",title:"Potassium in Solid Cancers",doi:"10.5772/intechopen.101108",signatures:"Jessica Iorio, Lisa Lastraioli and Elena Lastraioli",slug:"potassium-in-solid-cancers",totalDownloads:119,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"78820",title:"Potassium Homeostasis",doi:"10.5772/intechopen.100368",signatures:"Shakuntala S. Patil and Sachin M. Patil",slug:"potassium-homeostasis",totalDownloads:108,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}},{id:"78193",title:"Potassium and Cardiac Surgery",doi:"10.5772/intechopen.99735",signatures:"Shawn Kant, Frank W. Sellke and Jun Feng",slug:"potassium-and-cardiac-surgery",totalDownloads:175,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Potassium in Human Health",coverURL:"https://cdn.intechopen.com/books/images_new/10794.jpg",subseries:{id:"12",title:"Human Physiology"}}}]},publishedBooks:{},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.jpg",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/38496",hash:"",query:{},params:{id:"38496"},fullPath:"/chapters/38496",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()