The average PSNR (dB) values of different resolution enhancement techniques on the test video sequences.
\r\n\tThere will be a chapter on secondary causes of sexual dysfunction disorders related to diabetes, cardiovascular disease, and obesity. A chapter on remedial measures to enhance sexual activity and maintain human relationships will be discussed. As there is a growing number of cancer survivors a chapter on cancer-related sexual dysfunction will be welcomed for including it.
",isbn:null,printIsbn:null,pdfIsbn:null,doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!0,isSalesforceBook:!1,isNomenclature:!1,hash:"b988fda30a4e2364ee9d47e417bd0ba9",bookSignature:"Dr. Dhastagir Sultan Sheriff",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11889.jpg",keywords:"Sex, Sexual Response Cycle, Erection, Premature Ejaculation, Libido, Orgasm, Painful Intercourse, Psychological, Female, Lack of Desire, Erectile Disorders, Pain Disorders",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 8th 2022",dateEndSecondStepPublish:"May 6th 2022",dateEndThirdStepPublish:"July 5th 2022",dateEndFourthStepPublish:"September 23rd 2022",dateEndFifthStepPublish:"November 22nd 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dhastagir Sultan Sheriff is a life member of the European Society for Human Reproduction and Early Human Development, Association of Physiologists and Pharmacologists of India, member of the National Academy of Medical Sciences, New Delhi, and resource person for UNESCO for Medical and Bioethics. Dr. Sheriff has authored five books including a textbook on medical biochemistry with additional interest in human sexology. He has done extensive research in andrology, sex education, and counseling.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"167875",title:"Dr.",name:"Dhastagir Sultan",middleName:null,surname:"Sheriff",slug:"dhastagir-sultan-sheriff",fullName:"Dhastagir Sultan Sheriff",profilePictureURL:"https://mts.intechopen.com/storage/users/167875/images/system/167875.jpg",biography:"Dhastagir Sultan Sheriff is a life member of the European Society for Human Reproduction and Early Human Development, Association of Physiologists and Pharmacologists of India, member of the National Academy of Medical Sciences, New Delhi, and resource person for UNESCO for Medical and Bioethics. Dr. Sheriff has authored five books including a textbook on medical biochemistry with additional interest in human sexology. He had editorials written in the British Journal of Sexology, Journal of Royal Society of Medicine, Postgraduate Medicine, and Scientist. 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That is one of the reasons that nowadays resolution enhancements of low resolution video sequences are at the centre of interest of many researchers. There are two main approaches in the literature for performing the resolution enhancement. The first approach is multi-frame super resolution based on the combination of image information from several similar images taken from a video sequence (M. Elad and A. Feuer, PAMI, 1999). The second approach is referred as single-frame super resolution, which uses prior training data to enforce super resolution over a single low resolution input image. In this work we are following the first approach which is multi frame resolution enhancement taken from low resolution video sequences.
\n\t\t\tTsai and Huang are the pioneers of super resolution idea (1984). They used the frequency domain approach. Further work has been conducted by Keren et al. (1988) describing a spatial domain procedure by using a global translation and rotation model in order to perform image registration. Furthermore, Reddy and Chatterji (1996) introduced a frequency domain approach for super resolution. Later on, Cortelazzo and Lucchese (2000) presented a method for estimating planar roto-translations that operates in the frequency domain. Irani and Peleg (1991) have developed a motion estimation algorithm, which considers translations and rotations in spatial domain. Meanwhile, further researches have been conducted on developing on resolution enhancement of low resolution video sequences (\n\t\t\t\t\tDemirel and Izadpanahi, 2008\n\t\t\t\t, B. Marcel, M. Briot, and R. Murrieta, 1997, Demirel et al. [EUSIPCO] 2009, N. Nguyen and P. Milanfar, 2000, Robinson et al 2010). Vandewalle et al. (2006) considered a frequency domain technique to specifically register a set of aliased images. In their method images were differently considered by a planar motion method. Their proposed algorithm used low-frequency information which has the highest signal-to-noise ratio (SNR), and in their setup, the aliasing-free part of the images.
\n\t\t\tWavelet transform is also being widely used in many image processing applications, especially in image and video super resolution techniques (Piao et al. 2007, Demirel et al. [IEEE Geoscience and Remote Sensing Letter] 2010, Temizel and Vlachos 2005, Demirel and Anbarjafari 2010, Anbarjafari and \n\t\t\t\t\t\tDemirel [ETRI], 2010\n\t\t\t\t\t\n\t\t\t\t). A one-level discrete wavelet transform (DWT) of a single frame of a video sequence produces a low frequency subband, and three high frequency subbands oriented at 0 , 45 , and 90 (Mallat,1999).
\n\t\t\tIn this work, we have proposed a new video resolution enhancement technique which generates sharper super resolved video frames. The proposed technique uses DWT to decompose low resolution frames of the video sequences into four subbands, namely, low-low (LL), low-high (LH), high-low (HL), and high-high (HH). Then the three high frequency subbands (LH, HL, and HH subbands) of the respective frames have been enlarged by using bicubic interpolation. In parallel, the input low resolution frames have been super resolved by using Irani and Peleg technique separately (Irani and Peleg, 1991). Illumination inconsistence can be attributed to uncontrolled environments. Because Irani and Peleg registration technique is used, it is an advantage that the frames used in the registration process have the same illumination. In this paper, we have also proposed a new illumination compensation method by using singular value decomposition (SVD). The illumination compensation technique is performed on the frames before the implementation of Irani and Peleg resolution enhancement technique. Finally, the interpolated high frequency subbands, obtained from DWT of the corresponding frames, and their respective super resolved input frames have been combined by using inverse DWT (IDWT) to reconstruct a high resolution output video sequence. The proposed technique has been compared with several state-of-art image resolution enhancement techniques. The following registration techniques are used for comparison purposes:
\n\t\t\t\n\t\t\t\t\t\tCortelazzo and Lucchese registration technique (2000)\n\t\t\t\t\t
\n\t\t\t\t\t\tMarcel et al., registration technique (1997)\n\t\t\t\t\t
\n\t\t\t\t\t\tVandewalle et al., registration technique (2006)\n\t\t\t\t\t
\n\t\t\t\t\t\tKeren et al., registration technique (1988),\n\t\t\t\t\t
The reconstruction techniques used in this work for comparison are:
\n\t\t\tBicubic interpolation
Iterated Back Projection (1991)
Robust super resolution technique (Zomet et al., 2001)
Structure Adaptive Normalized Convolution (Pham et al., 2006)
The experimental results are showing that the proposed method overcomes the aforementioned resolution enhancement techniques. Also as it will be shown in the experimental section, the proposed illumination compensation improves the quality of the super resolved sequence (the PSNR) by 2.26 dB for Akiyo video sequence.
\n\t\tIn this section a brief introduction of four super resolution methods, which have been used to compare the performance of the proposed super resolution technique, are reviewed.
\n\t\t\tLucchese et al. super resolution method operates in the frequency domain. The estimation of relative motion parameters between the reference image and each of the other input images is based on the following property: The amplitude of the Fourier transform of an image and the mirrored version of the amplitude of the Fourier transform of a rotated image have a pair of orthogonal zero-crossing lines. The angle that these lines make with the axes is identical to half the rotation angle between the two images. Thus the rotation angle will be computed by finding these two zero crossings lines. This algorithm uses a three-stage coarsest to finest procedure for rotation angle estimation with a wide range of degree accuracy. The shift is estimated afterwards using a standard phase correlation method.
\n\t\t\tIn this method a registration algorithm that uses the Fourier domain approach to align images which are translated and rotated with respect to one another, was proposed. Using a log-polar transform of the magnitude of the frequency spectra, image rotation and scale can be converted into horizontal and vertical shifts. These can therefore also be estimated using a phase correlation method. Their method utilizes reparability of rotational and translational components property of the Fourier transform. According to this property, the translation only affects the phase information, whereas the rotation affects both phase and amplitude of the Fourier transform. One of the properties of the 2D Fourier Transform is that if we rotate the image, the spectrum will rotate in the same direction. Therefore, the rotational component can first be estimated. Then, after compensating for rotation, and by using phase correlation techniques, the translational component can be estimated easily.
\n\t\t\tIrani et al. have developed a motion estimation algorithm. This algorithm considers translations and rotations in spatial domain. The motion parameters which are unknown can be computed from the set of approximation that can be derived from the following equation (1), where the horizontal shift
Finally, after determining and applying the results, the error measure between images g1 and g2 is approximated by (1) where this summation is counted over overlapping areas of both images.
\n\t\t\t\tFor reducing E to its minimal value and obtaining more accurate result, the linear system in (5) is applied. By solving the following matrix, the horizontal shift
\n\t\t\t\t\tFig. 1 (a-d) shows the four low resolution consecutive frames, where (e), (f) and (g) shows super resolved high resolution images by using Cortelazzo et al., Reddy et al., and Irani et. al methods respectively.
\n\t\t\t\ta) through (d) are four low resolution images taken from a video sequence. (e) High resolution image of (a) through (d) using Cortelazzo et al. (f), Reddy et al. (g) and Irani et al. methods.
The main loss of an image or a video frame after being super resolved is on its high frequency components (i.e. edges), which is due to the smoothing caused by super resolution techniques. Hence, in order to increase the quality of the super resolved image, preserving the edges is essential. Hence, DWT has been employed in order to preserve the high frequency components of the image by decomposing a frame into different subband images, namely Low-Low (LL), Low-High (LH), High-Low (HL), and High-High (HH).
\n\t\t\t\tLH, HL, and HH subband images contain the high frequency components of the input frame. The DWT process for each frame of the input video generates 4 video sequences in each subband (i.e. LL, LH, HL and HH video sequences). Then, the Irani et al. super resolution method in (1991) is applied to all subband video sequences separately. This process results in 4 super resolved subband video sequences. Finally, IDWT is used to combine the super resolved subbands to produce the high resolution video sequence.
\n\t\t\t\tBy super resolving the LL, LH, HL and HH video sequences and then by applying IDWT, the output video sequence would contain sharper edges than the super resolved video sequence obtained by any of the aforementioned super resolution techniques directly. This is due to the fact that, the super resolution of isolated high frequency components in HH, HL and LH will preserve more high frequency components after the super resolution of the respective subbands separately than super resolving the low resolution image directly.
\n\t\t\t\tIn this technique, the moving regions are extracted to be super resolved with the proposed super resolution technique explained above. The static regions are similarly transformed into wavelet domain and each static subband sequence is interpolated by bicubic interpolation. The high resolution sequence of the static region is generated by composing the interpolated frames using the IDWT. Eventually, the super resolved sequence is achieved by combining the super resolved moving sequence and the interpolated static region sequence.
\n\t\t\t\tThe method can be summarized with the following steps:
\n\t\t\t\t1. Acquire frames from video and extract motion region(s) using frame subtraction.
\n\t\t\t\t2. Determine the significant local motion region(s) by applying connected component labeling.
\n\t\t\t\t3. Apply DWT to decompose the static background region into different subbands.
\n\t\t\t\t4. Apply bicubic interpolation for enhancing resolution of each subband obtained from step 3.
\n\t\t\t\t5. Use IDWT to reconstruct the super resolved static background.
\n\t\t\t\t6. Apply DWT to decompose the moving foreground region(s) into different subbands.
\n\t\t\t\t7. Super resolve the extracted subbands by applying Irani et al. super resolution method.
\n\t\t\t\t8. Use IDWT to reconstruct the super resolved moving region(s).
\n\t\t\t\t9. Combine the sequences obtained from steps (5) and (8) to generate the final super resolved vide sequence.
\n\t\t\t\tIn the first step, four consecutive frames are used where each frame is subtracted from the reference frame so the differences between frames are extracted. After applying OR operation for all subtracted images local motion(s) will appear.
\n\t\t\t\tIn the second step, the area of local motion(s) can be determined by using connected component labeling. In the third, fourth, and fifth steps the rest of the frames which does not include any motion and it is static, will be decomposed by DWT, interpolated with the help of bicubic interpolation, and composed by IDWT.
\n\t\t\t\tFirst four consecutive frames taken from a video sequence with one moving region. The rectangular moving part for each four frames is changing adaptively.
\n\t\t\t\t\tFig. 2 shows four consecutive frames taken from a video sequence. The second frame is used as the reference frame. The rectangular part shown in each frame corresponds to the moving part. The rest of the reference frame is the static part. In every four frame the rectangular moving part will change according to the moving part in those frames.
\n\t\t\t\tIn the sixth, seventh and eighth steps, motion parts will be decomposed into different subbands by DWT, super resolved by using Irani et al. super resolution technique, and all subbands will be composed by IDWT.
\n\t\t\t\tIn the final step, we combine super resolved motion frames with the interpolated background to achieve the final high resolution video sequence. The algorithm is shown in Fig. 3.
\n\t\t\t\tThe algorithm of the proposed super resolution method for video enhancement.
As mentioned in the introduction, there are many super resolution techniques for enhancing the resolution of the video sequences. The main loss of a video frame after being super resolved is on its high frequency components (i.e. edges), which is due to the smoothing caused within the super resolution processes. Also in many video resolution enhancement techniques due to slight changes in illumination of the successive frames, registration will be done poorly which causes drop in the quality of the super resolved sequence. Therefore, in order to increase the quality of the super resolved video sequence, preserving the edges (high frequencies) of each frame and correcting the slight illumination differences can increase the quality of the super resolved sequence.
\n\t\t\tIn the present work, the Irani and Peleg registration technique is used for registration in which at each stage four successive frames are used. The frames can be named as
in which
Then the enhanced frame is constructed by using:
\n\t\t\tBecause after obtaining the enhanced frame, it will be converted into 8-bit representation (quantization will take the place), therefore highest singular value obtained from the repetition of equation (8) will slightly differ from the highest singular value in the right hand side of equation (10). The algorithm of the illumination enhancement technique is shown in Fig. 4.
\n\t\t\tThe illumination compensation technique used before the registration.
\n\t\t\t\tFig. 5 is showing the convergence of pixel average of two of the frames towards the reference frame for Akiyo video sequence in progressive iterations.
\n\t\t\tIn this work, discrete wavelet transform (DWT) (Mallat, 1999) has been applied in order to preserve the high frequency components of each frame. The one level DWT process for each frame of the input video generates four video sequences (i.e. LL subband sequences and three high frequency subband sequences with 0 , 45 , and +90 orientations known as LH, HL, and HH subbands). In parallel to DWT process, the Irani and Peleg super resolution technique is applied to video sequences in spatial domain. This process results in super resolved frame which can be regarded as a LL subband of a higher (target) resolution frame. The LH, HL, and HH subbands of the higher (target) resolution frames are generated by interpolation of the previously extracted LH, HL, and HH subbands from the input reference frames. Finally, Inverse DWT (IDWT) is used to reconstruct the super resolved subbands to produce the resolution enhanced frame, resulting in a high resolution video sequence.
\n\t\tThe convergence of the mean of the first (blue) and the third (red) frames of the Akiyo sequence to the mean of the second frame (reference).
By super resolving the different subbands of video sequences and then by applying IDWT, the output video sequence contains sharper edges. This is due to the fact that, the proposed super resolution technique isolates high frequency components and preserves more high frequency components after the super resolution of the respective subbands separately than other super resolution technique.
\n\t\t\tThe proposed method can be summarized with the following steps:
\n\t\t\t10. Acquire frames from a video.
\n\t\t\t11. Apply the proposed illumination compensation technique before registration.
\n\t\t\t12. Apply DWT to decompose the low resolution input video sequence into different subband sequences.
\n\t\t\t13. Super resolve the original corresponding frame by applying Irani and Peleg super resolution technique.
\n\t\t\t14. Apply bicubic interpolation to the extracted high frequency subbands (LH, HL, and HH).
\n\t\t\t15. Apply IDWT to the output of step 4 and three outputs of step 5 in order to reconstruct the high resolution super resolved sequence.
\n\t\t\tIn the fourth step, four illumination compensated consecutive frames are used for registration in implementation of Irani and Peleg super resolution technique. Fig. 6 illustrates the block diagram of the proposed video resolution enhancement technique.
\n\t\t\tA possible application of the proposed resolution enhancement technique is that if someone is holding his/her digital camera while taking a series of four shoots of a scene within a short period of time. The small translation of the person’s hands during capturing the snapshots which may cause some illumination changes is sufficient to reconstruct the high resolution image.
\n\t\t\tIn all steps of the proposed technique db.9/7 wavelet function and bicubic interpolation are used. In the next section, the result of comparison between the proposed technique with the conventional and state-of-art techniques mentioned in the introduction is reported. The quantitative results are showing the superiority of the proposed method over the other techniques.
\n\t\t\tThe block diagram of the proposed video resolution enhancement technique.
Super resolution method proposed in this paper is compared with the state-of-art super resolution techniques using Vandewalle (2006), Marcel (1997), Lucchese (2000), and Keren (1988) registration followed by interpolation, iterated back projection, robust super resolution, and structure adaptive normalized convolution techniques for reconstruction. The proposed method has been tested on four well known video sequences (Xiph.org Test Media, 2010), namely Mother daughter, Akiyo, Foreman, and Container. Table 1 is showing the PSNR value of the aforementioned super resolution techniques for the above video sequences.
\n\t\t\tVandewalle | \n\t\t\t\t\t\tInterpolation | \n\t\t\t\t\t\t24.29 | \n\t\t\t\t\t\t29.45 | \n\t\t\t\t\t\t28.01 | \n\t\t\t\t\t\t23.6 | \n\t\t\t\t\t
Iterated Back Projection | \n\t\t\t\t\t\t27.1 | \n\t\t\t\t\t\t31.49 | \n\t\t\t\t\t\t30.17 | \n\t\t\t\t\t\t24.3 | \n\t\t\t\t\t|
Robust SR | \n\t\t\t\t\t\t27.15 | \n\t\t\t\t\t\t31.5 | \n\t\t\t\t\t\t30.24 | \n\t\t\t\t\t\t24.46 | \n\t\t\t\t\t|
Structure Adaptive Normalized Convolution | \n\t\t\t\t\t\t28.95 | \n\t\t\t\t\t\t32.98 | \n\t\t\t\t\t\t33.46 | \n\t\t\t\t\t\t26.38 | \n\t\t\t\t\t|
Marcel | \n\t\t\t\t\t\tInterpolation | \n\t\t\t\t\t\t24.44 | \n\t\t\t\t\t\t29.6 | \n\t\t\t\t\t\t28.16 | \n\t\t\t\t\t\t24.96 | \n\t\t\t\t\t
Iterated Back Projection | \n\t\t\t\t\t\t27.12 | \n\t\t\t\t\t\t31.52 | \n\t\t\t\t\t\t29.84 | \n\t\t\t\t\t\t25.2 | \n\t\t\t\t\t|
Robust SR | \n\t\t\t\t\t\t27.18 | \n\t\t\t\t\t\t31.54 | \n\t\t\t\t\t\t30.24 | \n\t\t\t\t\t\t25.25 | \n\t\t\t\t\t|
Structure Adaptive Normalized Convolution | \n\t\t\t\t\t\t28.66 | \n\t\t\t\t\t\t33.16 | \n\t\t\t\t\t\t33.25 | \n\t\t\t\t\t\t26.28 | \n\t\t\t\t\t|
Lucchese | \n\t\t\t\t\t\tInterpolation | \n\t\t\t\t\t\t24.1 | \n\t\t\t\t\t\t29.62 | \n\t\t\t\t\t\t28.19 | \n\t\t\t\t\t\t24.53 | \n\t\t\t\t\t
Iterated Back Projection | \n\t\t\t\t\t\t27.06 | \n\t\t\t\t\t\t31.52 | \n\t\t\t\t\t\t29.88 | \n\t\t\t\t\t\t25.28 | \n\t\t\t\t\t|
Robust SR | \n\t\t\t\t\t\t27.13 | \n\t\t\t\t\t\t31.55 | \n\t\t\t\t\t\t30.29 | \n\t\t\t\t\t\t25.31 | \n\t\t\t\t\t|
Structure Adaptive Normalized Convolution | \n\t\t\t\t\t\t29.01 | \n\t\t\t\t\t\t32.8 | \n\t\t\t\t\t\t33.3 | \n\t\t\t\t\t\t26.36 | \n\t\t\t\t\t|
Keren | \n\t\t\t\t\t\tInterpolation | \n\t\t\t\t\t\t23.16 | \n\t\t\t\t\t\t29.6 | \n\t\t\t\t\t\t28.17 | \n\t\t\t\t\t\t24.78 | \n\t\t\t\t\t
Iterated Back Projection | \n\t\t\t\t\t\t27.17 | \n\t\t\t\t\t\t31.53 | \n\t\t\t\t\t\t29.87 | \n\t\t\t\t\t\t25.31 | \n\t\t\t\t\t|
Robust SR | \n\t\t\t\t\t\t27.2 | \n\t\t\t\t\t\t31.55 | \n\t\t\t\t\t\t30.29 | \n\t\t\t\t\t\t25.46 | \n\t\t\t\t\t|
Structure Adaptive Normalized Convolution | \n\t\t\t\t\t\t28.63 | \n\t\t\t\t\t\t32.97 | \n\t\t\t\t\t\t33.25 | \n\t\t\t\t\t\t26.15 | \n\t\t\t\t\t|
Proposed resolution enhancement technique without illumination compensation | \n\t\t\t\t\t\t31.53 | \n\t\t\t\t\t\t34.07 | \n\t\t\t\t\t\t35.87 | \n\t\t\t\t\t\t28.94 | \n\t\t\t\t\t|
Proposed resolution enhancement technique with illumination compensation | \n\t\t\t\t\t\t32.17 | \n\t\t\t\t\t\t35.24 | \n\t\t\t\t\t\t36.52 | \n\t\t\t\t\t\t30.07 | \n\t\t\t\t\t
The average PSNR (dB) values of different resolution enhancement techniques on the test video sequences.
The low resolution video sequences are generated by downsampling and lowpass filtering each frame of the high resolution video sequence (Temizel, 2007). In this way we keep the original high resolution video sequences for comparison purposes as a ground truth. All video sequences have 300 frames and the reported average PSNR values in Table 1 are the average of 300 PSNR values. The low resolution video sequences have the size of 128x128 and the super resolved sequences have the size of 256x256.
\n\t\t\t\n\t\t\t\tFig. 7 is demonstrating the visual result of the proposed method for proposed method compared with other state-of-art techniques for ‘mother-daughter’ video sequences. As it is observable from Fig. 4, the proposed method is results in a sharper image compared with the other conventional and state-of-art video super resolution techniques.
\n\t\t\tThe visual representation of a frame of low resolution of ‘mother-daughter’ video sequence (a) and a zoomed segment of the frame (b), and the super resolved frame by using: Keren (c), Lucchese (d), Marcel (e), Vandewalle (f) registration technique with Structure Adaptive Normalized Convolution reconstruction technique, and the proposed technique (g).
This paper proposes a new video resolution enhancement technique by applying an illumination compensation technique based on SVD before registration process and using DWT in order to preserve the high frequency components of the frames. The output of the Irani and Peleg technique is used as LL subband in which LH, HL, and HH subbands are obtained by using bicubic interpolation of the former high frequency subbands. Afterwards all these subbands have been combined using IDWT to generate respective super resolved frame. The proposed technique has been tested on various well known video sequences, where the quantitative results show the superiority of proposed technique over the conventional and state-of-art video super resolution techniques.
\n\t\t\t\n\t\tAuthors would like to thank Prof. Dr. Ivan Selesnick from Polytechnic University for providing the DWT codes in MATLAB.
\n\t\tBladder cancer is the most frequent genitourinary malignancy in both men and women. They are divided into two groups—urothelial and nonurothelial.
The bladder is located in the midline just behind the pubic bone. The bladder is separated from the pubic bone by the retropubic space, also known as the Retzius space, including the Santorini venous plexus. The symphysis pubis, laterally the pelvic sidewalls, posteriorly and inferiorly the lower uterine segment, anterior cervix, and vagina are the bladder’s boundaries. The obliterated umbilical artery and urachus correspond to the upper border of the bladder. The urachus connects the developing bladder to the umbilicus in the fetus. After birth, the urachus curves into the median umbilical ligament, which connects the apex of the bladder to the anterior abdominal wall. Sometimes, the urachus remains patent. The bladder dome is located next to the anterior abdominal wall’s parietal peritoneum. The bladder is pushed into the vesicouterine space by the peritoneum below. The bladder’s thick parts are retroperitoneal. The bladder is an organ that has the ability to expand. When empty, it has the shape of a pyramid. The tip points to the pubic bone. It becomes a sphere when it is full, with a capacity of about 400–500 cc in a healthy adult individual, and it changes from a pelvic to an abdominal organ in this state. When the dome is completely filled, the dome’s structure becomes thinner than the dome’s other parts. As a result, emptying the bladder with the aid of a catheter before beginning pelvic surgery can assist in preventing bladder injuries. The upper dome and lower floor are present in the bladder. The bladder floor, which comprises the trigone and detrusor ring, is located directly on the anterior wall of the vagina. Thickening of the detrusor muscle is a thickening that does not change directly with bladder filling. The area between the two ureteral orifices and the internal urethral meatus is known as the bladder trigone. The two ureteral orifices and the internal urethral meatus are 3 cm apart. The intraurethral ridge is a rise in the trigone between the ureteral orifices [1].
The bladder wall is made up of four layers:
Urothelium
The urothelium is the bladder’s innermost layer, consisting of transitional epithelial cells. Bladder cancer originates in the urothelial layer.
Lamina propria
A thin basement membrane separates the lamina propria (subepithelial connective tissue) from the urothelium. This layer consists of rich connective tissue containing vascular and neuronal structures. Thin, smooth muscle fibers may be present in the middle of this layer, partially or as a separate layer, along with the vascular plexus. This area is also called muscular mucosa.
Muscularis propria
The muscularis propria (detrusor muscle) are thick, interlocking, irregular muscle bundles surrounding the lamina propria. When the bladder contracts, the detrusor muscle’s plexiform structure is ideal for reducing all lumen dimensions. Small muscle fibers in the lamina propria (muscularis mucosa) described above can be confused with this layer in small biopsies, potentially leading to incorrect tumor staging. The lamina propria and/or muscularis propria may include adipose tissue. Therefore, the presence of a tumor in adipose tissue does not always indicate extravesical spread.
Serosa (adventitia)
It is the name for the perivesical adipose tissue outside the muscularis propria [1, 2].
The superior and inferior vesical arteries, which arise from the anterior branch of the internal iliac artery, give blood to the bladder. The pelvic and hypogastric nerve plexuses’ parasympathetic and sympathetic autonomic fibers supply bladder innervation [1].
Nonurothelial bladder cancer makes up fewer than 5% of all bladder tumors [3]. About 90% of nonurothelial bladder cancers are epithelial in origin. Most of them are squamous cell carcinomas; other rare types are adenocarcinomas and small cell carcinomas. Non-epithelial tumors include sarcomas, carcinosarcomas, paragangliomas, melanomas, and lymphomas.
The pathogenesis of nonurothelial bladder cancers is not fully understood. The presence of chronic infection and metaplasia development are believed to be crucial factors in tumorigenesis. Alternative hypotheses include the development of nonurothelial bladder cancers from pre-existing urothelial (transitional cell) carcinomas undergoing metaplasia [4] and tumor growth from multipotent stem cells in the bladder.
Chronic infection and inflammation cause tissue metaplasia, resulting in the development of either squamous epithelium and leukoplakia or mucous and glandular epithelium. The factors that cause neoplastic transformation, on the other hand, are unknown.
Squamous cell carcinomas are frequently associated with squamous metaplasia and occur in 16–28% of leukoplakia patients [5, 6].
Adenocarcinoma has been linked to two models of metaplasia. Invagination of hyperplastic epithelial buds into the lamina propria causes cystitis cystica, which can progress to metaplasia and cystitis glandularis and is linked to vesical adenocarcinoma. Hyperplasia of epithelial mother cells is shown in a second pattern, but there is no invagination into the lamina propria.
Both non-schistosomal and schistosomal bladder cancer are associated with chronic urinary tract infections (UTIs). Infection may play a role in the development of bladder cancer through a variety of mechanisms, including:
Predisposition to metaplasia is the first step in carcinogenesis.
Gram-negative bacteria, such as
Inflammatory cells’ production of reactive oxygen species in response to infection causes DNA damage and the activation of additional carcinogens.
Patients with nonurothelial bladder cancer often have painless hematuria (visible or microscopic), but irritating urination symptoms (frequency, urgency, and dysuria) may be the initial indicator, similar to urothelial carcinomas.
Nonurothelial bladder cancers have a variety of less common presentations, including:
Mucusuria has been described in bladder adenocarcinomas and is more common in urachal adenocarcinomas than in non-urachal adenocarcinomas.
The presence of an abdominal mass is more common in urachal adenocarcinoma compared to in non-urachal adenocarcinoma.
Cystoscopy is the gold standard for diagnosing a patient with a suspected bladder neoplasm, and cystoscopic biopsy typically gives tissue for a definite diagnosis. Compared to urothelial cancers, non-urothelial tumors are more likely to be muscle-invasive at diagnosis and more likely to be staged at the time of surgery because precise pathological staging is available. Therefore, as a group, non-urothelial tumors occur at a more advanced stage and contribute to a worse prognosis compared to urothelial cancers [13]. However, an interesting observation is that urachal cancers tend to have a better prognosis at presentation than urothelial cancers at a similar stage (Table 1) [14].
TX | Primary tumor unknown |
T0 | No evidence of primary tumor |
Ta | Noninvasive papillary tumor |
Tis | Carcinoma |
T1 | Invasive to the lamina propria |
T2 | Invasive into the muscularis propria |
pT2a | Invasive into the superficial muscularis propria |
pT2b | Invasive into the deep muscularis propria |
T3 | Invasive perivesical adipose tissue |
pT3a | Microscopic |
pT3b | Macroscopic |
T4 | Extravesical tumor invasive of either the prostatic stroma, seminal vesicle, uterus, vagina, pelvic wall, or abdominal wall |
T4a | Extravesical tumor invading the prostatic stroma, seminal vesicle, uterus, and vagina |
T4b | Extravesical tumor of the pelvic wall, invasive into the abdominal wall |
NX | Lymph node metastasis unknown |
N0 | No lymph node metastases |
N1 | Single regional lymph node metastasis in the true pelvis (perivesical, obturator, internal iliac, external iliac, or sacral lymph node) |
N2 | Multiple regional lymph node metastases in the true pelvis (perivesical, obturator, internal iliac, external iliac, or sacral lymph nodes) |
N3 | Common iliac lymph node metastasis |
M0 | No distant metastases |
M1 | There is distant metastasis |
M1a | Distant metastasis limited beyond the common iliac |
M1b | Presence of distant metastases without lymph node metastasis |
Ta | N0 | M0 | 0a |
Tis | N0 | M0 | 0is |
T1 | N0 | M0 | I |
T2a | N0 | M0 | II |
T2b | N0 | M0 | II |
T3a, T3b, T4a | N0 | M0 | IIIA |
T1-T4a | N1 | M0 | IIIA |
T1-T4a | N2, N3 | M0 | IIIB |
T4b | Any N | M0 | IVA |
Any T | Any N | M1a | IVA |
Any T | Any N | M1b | IVB |
AJCC cancer staging 2017.
The treatment of nonurothelial bladder tumors is mainly based on retrospective series and small trials due to their rarity and heterogeneity. As a result, the approach to patients with urothelial bladder cancer is frequently used to estimate treatment.
Cystectomy is the primary treatment for patients with localized illness. This should include a lymph node dissection with radical cystectomy for individuals with squamous carcinoma, adenocarcinoma, or schistosomal bladder cancer (regardless of histology).
Nonurothelial carcinomas of the bladder, ureter, or renal pelvis are not recommended for preoperative or postoperative chemotherapy because they are less responsive to chemotherapy than urothelial carcinomas and were not included in the phase III trials.
Although radiation therapy (RT) before cystectomy may play a role in schistosomal bladder cancer, it is not a standard treatment approach for other bladder tumors [15, 16]. There are no high-quality data on the role of chemotherapy and/or RT as adjuvant therapy.
Palliative care, RT, or chemotherapy are options for patients with advanced nonurothelial bladder cancer who are not candidates for surgery, including those with metastatic disease. Such patients should participate in clinical trials whenever possible. However, a trial of chemotherapy is reasonable in patients who are candidates for chemotherapy and are in good performance status. When deciding on treatment, it should be kept in mind that there are no prospective data that provide information on the benefits of treatment compared with the risks associated with treatment.
Because trials for certain groups of nonurothelial carcinomas are not common, these patients are often candidates for early phase clinical trials and “basket studies” that allow enrollment of tumors with specific mutations that are considered “vulnerable” to the drug being offered. According to case reports, nonurothelial malignancies may react to targeted agents found by molecular profiling techniques, such as next-generation sequencing [17, 18]. Patients with potentially actionable mutations in their tumors should be included in clinical studies that capture molecular, response, and outcome data prospectively whenever possible [19, 20].
In North America and Europe, squamous cell carcinoma accounts for 3 to
Risk factors associated with the development of squamous cell carcinoma include chronic or recurrent urinary tract infections (UTIs), bladder stones, pelvic radiotherapy (RT), previous intravesical Bacillus Calmette-Guerin (BCG) therapy, and prolonged cyclophosphamide treatment, especially when complicated by hemorrhagic cystitis, in addition to schistosome infection [3]. Although smoking raises the risk of squamous cell carcinoma [21, 22], an observational study with long-term follow-up reveals that patients with pure squamous cell carcinoma are more likely to be female and have never smoked than patients with urothelial carcinoma [23]. In some studies, chronic indwelling catheters have also been associated with an increased risk of squamous cell carcinoma, while the relationship is controversial.
Although the design of these studies and the prevalence of squamous cell cancer and adenocarcinoma in these patients may have precluded a statistically significant result, two large population-based studies in patients with spinal cord injury did not find an increased risk of bladder cancer [24, 25]. However, muscle invasion was more common in bladder cancer detected in patients with neurogenic bladder, and researchers preferred intermittent catheterization to indwelling catheters [25]. Although some investigators have recommended regular screening cystoscopies for patients with spinal cord injury, no studies have proved a benefit of screening, perhaps because of the extremely low incidence of cancer in these patients [26, 27].
Surgery is the primary treatment for squamous cell carcinoma. Preoperative RT is appropriate, especially when complete resection is possible due to suspected locally advanced disease.
The role of surgery is supported by observational and retrospective data. In a study of 1422 patients diagnosed with bladder cancer between 1988 and 2003, the two-year all-cause mortality rate following cystectomy ranged from 11% in men with stage I disease to 72% in men with stage IV disease, according to the results of a Surveillance, Epidemiology, and Final Results (SEER) database analysis [28]. Squamous cell carcinoma histology was statistically associated with worse prognosis outcomes than urothelial bladder cancer histology when age, gender, race, and starting treatment were classified equally for both groups.
The tendency for local recurrence of bladder squamous cell carcinoma after radical cystectomy provides the rationale for preoperative or postoperative RT with or without radiosensitizing chemotherapy. Unfortunately, due to the small number of patients included, bias in patient selection, and treatment heterogeneity, the quality of available data is limited.
Because of the risk of intestinal toxicity and the difficulty of determining an appropriate RT treatment region after bladder removal, preoperative RT is preferable to postoperative therapy in such cases. However, several retrospective case series have indicated potential benefits of adjuvant or neoadjuvant RT [29, 30, 31, 32]. There has only been one prospective study on schistosomiasis infection, and the results may not apply to non-schistosomal squamous cell carcinoma.
Postoperative RT is a reasonable option for patients with locally progressed squamous cell bladder cancer following radical cystectomy unsuitable for or refusing adjuvant chemotherapy. New evidence supports its usage in patients with surgical margins that are positive [33]. In preliminary results of a randomized phase III trial of 123 patients with locally advanced bladder cancer (51% with urothelial carcinoma and 49% with squamous cell carcinoma or other carcinomas) after radical cystectomy versus adjuvant chemotherapy, RT improved local control (two-year local disease-free survival 92% vs. 69%, HR 0.28, 95% CI 0.10–0.82) [34]. The two treatment arms had similar disease-free survival, distant metastasis-free survival, and overall survival. Similar results were seen in a subgroup of patients with urothelial carcinoma [35].
Radiation combined with radiosensitizing chemotherapy (as is done for squamous cell carcinoma of the head and neck, anus, and uterine cervix) is a reasonable approach for patients with locally advanced, unresectable squamous cell carcinoma of the bladder, especially since these tumors tend to be locally aggressive. However, there are few forward-looking data to guide treatment.
Data from the phase III study BC2001 demonstrate efficacy for fluorouracil and mitomycin given with RT compared to RT alone in patients with high-grade muscular-invasive bladder cancer, who tend to have improved local and regional control and better survival [36]. Only 2.7% of patients in this trial had adenocarcinoma or squamous cell carcinoma, and there was no difference in outcomes compared to urothelial cancer. In patients with squamous cell carcinoma of the anus, a very comparable regimen is effective and well-tolerated; thus, extrapolation to squamous cell cancer of the bladder may be reasonable, especially in patients who are poor candidates for platinum-containing chemotherapy [37, 38].
Limited data suggest that squamous cell carcinoma tends to be locally advanced or worse at diagnosis and relatively resistant to chemotherapies used for metastatic urothelial carcinoma [23, 39, 40, 41]. We prefer that these patients participate in a prospective clinical trial in view of these results. The encouraging results of immunotherapy with T-cell checkpoint inhibitors using atezolizumab or pembrolizumab in advanced urothelial carcinoma previously treated with platinum-based therapy [42, 43], as well as the results of immunotherapy in patients with squamous cell carcinoma of the lung and head and neck tumors, support the inclusion of patients with squamous cell carcinoma of the urinary bladder in clinical trials, and we, therefore, continue to seek such trials for these patients [42, 43].
Treatment regimens used to treat metastatic urothelial cancer could be tried in the absence of a clinical trial. Based on phase II trial data in which six patients with bladder squamous cell carcinoma were treated with satisfactory results, similar to urothelial cancer patients in the same study, we recommend the combination of carboplatin, gemcitabine, and paclitaxel [44]. The experience from this trial is reproducible in our clinical practice for advanced squamous cell carcinoma of the bladder.
It is unclear whether nonurothelial bladder cancers have a worse prognosis, especially after controlling for stage and grade. After controlling for gender, stage, and grade, a multi-institutional study of 1131 consecutive patients (including 1042 with urothelial carcinoma and 89 with nonurothelial bladder cancer) found no differences in five-year survival following radical cystectomy [45].
Urothelial and nonurothelial bladder cancers are the two types of bladder cancer. Nonurothelial bladder cancers are further divided into epithelial and non-epithelial. Squamous cell carcinomas, adenocarcinomas, and small cell (neuroendocrine) tumors are epithelial cancers that account for around 90% of these cancers. Non-epithelial cancers are rare and include sarcomas, carcinosarcomas, paragangliomas, melanomas, and lymphomas. The pathogenesis of nonurothelial bladder cancers is not fully understood. The presence of chronic infection and inflammation, as well as the development of metaplasia, are regarded to be important factors in tumorigenesis. Like urothelial carcinomas, nonurothelial bladder carcinomas often present with hematuria and bladder irritation. Mucusuria has been described in bladder adenocarcinomas and is more common in urachal types than in non-urachal adenocarcinomas. The presence of an abdominal mass may also suggest a diagnosis of adenocarcinoma of the urinary bladder. Infection with
We would like to express our gratitude to all those who helped us during the writing of this manuscript. Thanks to all the peer reviewers and editors for their opinions and suggestions.
The authors declare no conflict of interest.
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His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. 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Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. 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Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"265335",title:"Mr.",name:"Stefan",middleName:"Radnev",surname:"Stefanov",slug:"stefan-stefanov",fullName:"Stefan Stefanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/265335/images/7562_n.jpg",biography:null,institutionString:null,institution:{name:"Medical University Plovdiv",country:{name:"Bulgaria"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. 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