Comparison of the effectiveness of interferon in chronic myeloproliferative disorders.
\\n\\n
More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:{caption:"IntechOpen Maintains",originalUrl:"/media/original/113"}},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"7695",leadTitle:null,fullTitle:"Green Energy Advances",title:"Green Energy Advances",subtitle:null,reviewType:"peer-reviewed",abstract:'This book contributes to understanding the development and application of green energy solutions. The term "green energy" is widely used today to indicate sustainable energy sources with zero or minimal environmental and economic impact, obtained from various renewable energy sources. The contents presented in this book deal with different solutions, from small-scale applications (thermoelectric energy harvesting) to energy efficiency in buildings with local renewable energy production (also in critical seismic sites), local energy systems (smart energy management of storage and complex interactions), exploitation of biomasses from agricultural wastes, and voluntary certifications associated with energy trading in large energy systems. These aspects mark a more sustainable evolution of the society with wider green energy usage.',isbn:"978-1-78984-200-5",printIsbn:"978-1-78984-199-2",pdfIsbn:"978-1-83962-051-5",doi:"10.5772/intechopen.77501",price:119,priceEur:129,priceUsd:155,slug:"green-energy-advances",numberOfPages:156,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"ca498ae0f824bac0c43f5cfb011d8e9c",bookSignature:"Diana Enescu",publishedDate:"February 20th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7695.jpg",numberOfDownloads:12876,numberOfWosCitations:50,numberOfCrossrefCitations:45,numberOfCrossrefCitationsByBook:12,numberOfDimensionsCitations:77,numberOfDimensionsCitationsByBook:16,hasAltmetrics:1,numberOfTotalCitations:172,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 25th 2018",dateEndSecondStepPublish:"May 16th 2018",dateEndThirdStepPublish:"July 15th 2018",dateEndFourthStepPublish:"October 3rd 2018",dateEndFifthStepPublish:"December 2nd 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"226207",title:"Ph.D.",name:"Diana",middleName:null,surname:"Enescu",slug:"diana-enescu",fullName:"Diana Enescu",profilePictureURL:"https://mts.intechopen.com/storage/users/226207/images/system/226207.jpeg",biography:"Diana Enescu graduated in Industrial Energy Engineering at the University Politehnica of Bucharest (UPB), Romania, and holds a Master Degree in energy efficiency and economy of energy from UPB. She obtained her PhD in mechanical engineering at the Technical University of Civil Engineering of Bucharest. In 2006 she was a visiting postdoctoral researcher at Yale University, USA. She has published more than 40 papers in national and international journals and conferences, four books and three book chapters. She is a member of ASME (American Society of Mechanical Engineers) and a reviewer of many international journals. She teaches thermal engineering courses at the Valahia University of Targoviste, Romania. Her research interests include heat transfer, thermodynamics, and thermoelectric system applications.",institutionString:"Valahia University of Targoviste",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Valahia University of Targoviste",institutionURL:null,country:{name:"Romania"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"771",title:"Sustainability Science",slug:"sustainability-science"}],chapters:[{id:"65239",title:"Thermoelectric Energy Harvesting: Basic Principles and Applications",doi:"10.5772/intechopen.83495",slug:"thermoelectric-energy-harvesting-basic-principles-and-applications",totalDownloads:5442,totalCrossrefCites:33,totalDimensionsCites:56,hasAltmetrics:1,abstract:"Green energy harvesting aims to supply electricity to electric or electronic systems from one or different energy sources present in the environment without grid connection or utilisation of batteries. These energy sources are solar (photovoltaic), movements (kinetic), radio-frequencies and thermal energy (thermoelectricity). The thermoelectric energy harvesting technology exploits the Seebeck effect. This effect describes the conversion of temperature gradient into electric power at the junctions of the thermoelectric elements of a thermoelectric generator (TEG) device. This device is a robust and highly reliable energy converter, which aims to generate electricity in applications in which the heat would be otherwise dissipated. The significant request for thermoelectric energy harvesting is justified by developing new thermoelectric materials and the design of new TEG devices. Moreover, the thermoelectric energy harvesting devices are used for waste heat harvesting in microscale applications. Potential TEG applications as energy harvesting modules are used in medical devices, sensors, buildings and consumer electronics. This chapter presents an overview of the fundamental principles of thermoelectric energy harvesting and their low-power applications.",signatures:"Diana Enescu",downloadPdfUrl:"/chapter/pdf-download/65239",previewPdfUrl:"/chapter/pdf-preview/65239",authors:[{id:"226207",title:"Ph.D.",name:"Diana",surname:"Enescu",slug:"diana-enescu",fullName:"Diana Enescu"}],corrections:null},{id:"63514",title:"Definition and Design of Zero Energy Buildings",doi:"10.5772/intechopen.80708",slug:"definition-and-design-of-zero-energy-buildings",totalDownloads:1568,totalCrossrefCites:4,totalDimensionsCites:6,hasAltmetrics:0,abstract:"The wide application of renewable energy system (RES) in buildings combined with numerous financial incentives on RES paves the way for future zero energy buildings (ZEB). Although the definition of ZEB still lacks a national building code and international standards, the number of ZEB projects is still increasing worldwide which seems to be the pioneer ZEB buildings. However, due to the intermittency of the renewable resources, various uncertain parameters, and dynamic electricity price from the grid, how to select the renewable energy system for buildings is one of the challenges and therefore becomes an extensive concern for both researchers and designers. In addition, questions like how to achieve the target of zero energy for different types of buildings, should the building be designed as an independent ZEB or a group of buildings to be a ZEB cluster, and how to make building owners actively involved in installing enough RES for the building are still on the air. This chapter will present a comprehensive view on several key issues related with ZEB, that is, definition, evaluation criteria, design method, and uncertainty analysis, and the penalty cost scheme is also proposed for consideration as one policy to assist the promotion of ZEB.",signatures:"Yuehong Lu, Xiao-Ping Zhang, Zhijia Huang, Jinli Lu and Changlong Wang",downloadPdfUrl:"/chapter/pdf-download/63514",previewPdfUrl:"/chapter/pdf-preview/63514",authors:[{id:"258333",title:"Associate Prof.",name:"Yuehong",surname:"Lu",slug:"yuehong-lu",fullName:"Yuehong Lu"},{id:"269313",title:"Prof.",name:"Zhijia",surname:"Huang",slug:"zhijia-huang",fullName:"Zhijia Huang"}],corrections:null},{id:"65163",title:"Energy and Seismic Rehabilitation of RC Buildings through an Integrated Approach: An Application Case Study",doi:"10.5772/intechopen.82581",slug:"energy-and-seismic-rehabilitation-of-rc-buildings-through-an-integrated-approach-an-application-case",totalDownloads:882,totalCrossrefCites:1,totalDimensionsCites:3,hasAltmetrics:0,abstract:"The high number of existing buildings in Italy without adequate seismic and thermal performances requires the definition of integrated retrofitting techniques in order to improve the seismic performance and to reduce energy losses at the same time. On one hand, an integrated approach appears mandatory considering that improving only the energy efficiency of nonseismic buildings leads to an increase of their exposure and, therefore, of their risk in the case of seismic events. On the other hand, seismic strengthening without an adequate thermal assessment and rehabilitation could compromise living comfort and energy maintenance costs. In this context, an application of integrated approach for the rehabilitation of reinforced concrete (RC) existing buildings has been proposed referring to a case study representative of the Italian building stock. Different configurations of infill panels have been considered in order to analyze both energy and seismic performance. Monthly quasi-steady state and hourly dynamic models have been used for the calculation of the energy need of buildings located in different Italian climate and seismic zones. Seismic performances have been evaluated by means of incremental nonlinear dynamic analysis (IDA). As-built and post-retrofit performances have been compared in order to evaluate the effectiveness of the proposed intervention solutions.",signatures:"Antonio D’Angola, Vincenzo Manfredi, Angelo Masi and Marianna Mecca",downloadPdfUrl:"/chapter/pdf-download/65163",previewPdfUrl:"/chapter/pdf-preview/65163",authors:[{id:"144482",title:"PhD.",name:"Antonio",surname:"Dangola",slug:"antonio-dangola",fullName:"Antonio Dangola"},{id:"281765",title:"Prof.",name:"Angelo",surname:"Masi",slug:"angelo-masi",fullName:"Angelo Masi"},{id:"281766",title:"Dr.",name:"Vincenzo",surname:"Manfredi",slug:"vincenzo-manfredi",fullName:"Vincenzo Manfredi"},{id:"281767",title:"Ph.D.",name:"Marianna",surname:"Mecca",slug:"marianna-mecca",fullName:"Marianna Mecca"}],corrections:null},{id:"63225",title:"A Smart Battery Management System for Photovoltaic Plants in Households Based on Raw Production Forecast",doi:"10.5772/intechopen.80562",slug:"a-smart-battery-management-system-for-photovoltaic-plants-in-households-based-on-raw-production-fore",totalDownloads:1553,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"A basic battery management system (BMS) permits the safe charge/discharge of the batteries and the supply of loads. Batteries are protected to avoid fast degradation: the minimum and maximum state-of-charge (SOC) limits are not exceeded and fast charge/discharge cycles are not permitted. A more sophisticated BMS connected to a photovoltaic (PV) generator could also work with the double purpose of protecting storage and reducing peak demand. Peak reduction by storage generally requires the forecast of consumption and PV generation profiles to perform a provisional energy balance. To do it, it is required to have accurate information about production profiles, that is, to have at disposal accurate weather forecasts, which are not easily available. In the present work, an efficient BMS in grid-connected PV plants for residential users is described. Starting from raw 1-day ahead weather forecast and prediction of consumption, the proposed BMS preserves battery charge when it is expected high load and low PV production and performs peak shaving with a negligible reduction in self-sufficiency.",signatures:"Filippo Spertino, Alessandro Ciocia, Paolo Di Leo, Gabriele Malgaroli\nand Angela Russo",downloadPdfUrl:"/chapter/pdf-download/63225",previewPdfUrl:"/chapter/pdf-preview/63225",authors:[{id:"52199",title:"Dr.",name:"Filippo",surname:"Spertino",slug:"filippo-spertino",fullName:"Filippo Spertino"},{id:"54831",title:"Dr.",name:"Paolo",surname:"Di Leo",slug:"paolo-di-leo",fullName:"Paolo Di Leo"},{id:"198475",title:"Prof.",name:"Angela",surname:"Russo",slug:"angela-russo",fullName:"Angela Russo"},{id:"258823",title:"Dr.",name:"Alessandro",surname:"Ciocia",slug:"alessandro-ciocia",fullName:"Alessandro Ciocia"},{id:"258824",title:"MSc.",name:"Gabriele",surname:"Malgaroli",slug:"gabriele-malgaroli",fullName:"Gabriele Malgaroli"}],corrections:null},{id:"65063",title:"Integration of Advanced Technologies for Efficient Operation of Smart Grids",doi:"10.5772/intechopen.83570",slug:"integration-of-advanced-technologies-for-efficient-operation-of-smart-grids",totalDownloads:1098,totalCrossrefCites:5,totalDimensionsCites:8,hasAltmetrics:0,abstract:"The current transition of electrical power systems toward smart grids is encompassing a fundamental change in their structure, as well as operation. This is setting the path to be followed by the hardware and software embedded in electrical power systems, as well as technology adaptation to the “open-source” customers’ needs and consumption patterns. This chapter is following the evolution of energy sector, accompanied by constant improvements of technology, which is providing increasingly complex hardware, which embeds power quality improvement devices, for an efficient operation of electrical power assets. This chapter presents a comprehensive survey of continuous advances of renewable energy sources and storage technology which have started the transformation of end users into energy-efficient and clean prosumers, underlining the subsequent energy markets support of peer-to-peer energy trading through novel technologies as blockchain.",signatures:"Radu Porumb and George Serițan",downloadPdfUrl:"/chapter/pdf-download/65063",previewPdfUrl:"/chapter/pdf-preview/65063",authors:[{id:"258532",title:"Associate Prof.",name:"Radu",surname:"Porumb",slug:"radu-porumb",fullName:"Radu Porumb"},{id:"258533",title:"Prof.",name:"George",surname:"Serițan",slug:"george-seritan",fullName:"George Serițan"}],corrections:null},{id:"64335",title:"Sustainable Energy Model for the Production of Biomass Briquettes Based on Rice Husks in Peruvian Low-Income Agricultural Areas",doi:"10.5772/intechopen.81817",slug:"sustainable-energy-model-for-the-production-of-biomass-briquettes-based-on-rice-husks-in-peruvian-lo",totalDownloads:1358,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"An energy model focuses on the sustainability of environmental proposals that use clean biomass technology. In this case, briquette production seeks to generate socio-environmental development in agricultural areas contaminated by the burning of rice husks. However, this agricultural waste product has a large heating capacity and can be used as a raw material for briquette production, replacing conventional contaminant fuels such as firewood and reducing Peru’s annual energy consumption by approximately 833,000 kg of CO2 per year, considering the minimization of emissions from the felling of trees and the burning of rice husks. These rice husks are burned and generate pollutant gases, causing respiratory and pulmonary problems. Despite these negative effects, it is an agricultural waste product with great untapped energy potential and constitutes an opportunity to promote socio-environmental development based on economic valorization. The level of deforestation would decrease by approximately 2070 trees per year, 23% of a market population which consumes 10 kg of firewood per day. Unlike similar projects, briquette production sustainability may be achieved when economic, environmental and social aspects are included in energy model development, based on the application of clean technology and efficient management of energy supplies, such as husk supplies and corresponding briquettes.",signatures:"Juan Arévalo, Grimaldo Quispe and Carlos Raymundo",downloadPdfUrl:"/chapter/pdf-download/64335",previewPdfUrl:"/chapter/pdf-preview/64335",authors:[{id:"256337",title:"Ph.D.",name:"Carlos",surname:"Raymundo",slug:"carlos-raymundo",fullName:"Carlos Raymundo"},{id:"272063",title:"Mr.",name:"Juan",surname:"Arevalo",slug:"juan-arevalo",fullName:"Juan Arevalo"},{id:"272064",title:"Dr.",name:"Grimaldo",surname:"Quispe",slug:"grimaldo-quispe",fullName:"Grimaldo Quispe"}],corrections:null},{id:"63953",title:"Voluntary Certification of Carbon Emission in Brazil - The Experience of an Electricity Trader",doi:"10.5772/intechopen.81185",slug:"voluntary-certification-of-carbon-emission-in-brazil-the-experience-of-an-electricity-trader",totalDownloads:976,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Few countries in the world have such availability of natural resources as Brazil. Even so, the country records increasing greenhouse gas (GHG) emissions related to electricity, and this is due to political and economic factors. This chapter shows the experience of the largest Brazilian power trader in its pioneering effort to develop voluntary certifications (2011) in power buy and sell transactions, along with other energy efficiency actions. The initiative has accumulated 9 years’ experience with more than 1600 units in different industries, using a methodology aligned with the Paris Agreement. The chapter presents the calculation methodology and the safeguards that ensure information integrity and verification of the certified indicators. Only renewable sources are used in this methodology, such sources being qualified as incentivized by their sustainability characteristics being small-size power plants (less than 30 MW of capacity installed).",signatures:"Fernando Amaral de Almeida Prado and Edvaldo Avila",downloadPdfUrl:"/chapter/pdf-download/63953",previewPdfUrl:"/chapter/pdf-preview/63953",authors:[{id:"257274",title:"Ph.D.",name:"Fernando",surname:"Almeida Prado Jr.",slug:"fernando-almeida-prado-jr.",fullName:"Fernando Almeida Prado Jr."},{id:"259329",title:"BSc.",name:"Edvaldo",surname:"Avila",slug:"edvaldo-avila",fullName:"Edvaldo Avila"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:[{id:"23",label:"women in science book program"}]},relatedBooks:[{type:"book",id:"205",title:"Fundamental and Advanced Topics in Wind Power",subtitle:null,isOpenForSubmission:!1,hash:"b8b5955addb75d98a6bba1c94e3e7a74",slug:"fundamental-and-advanced-topics-in-wind-power",bookSignature:"Rupp Carriveau",coverURL:"https://cdn.intechopen.com/books/images_new/205.jpg",editedByType:"Edited by",editors:[{id:"22234",title:"Dr.",name:"Rupp",surname:"Carriveau",slug:"rupp-carriveau",fullName:"Rupp Carriveau"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2706",title:"Small-Scale Energy Harvesting",subtitle:null,isOpenForSubmission:!1,hash:"63bc4c27bdf9ec1e00aa20ff6f1d804f",slug:"small-scale-energy-harvesting",bookSignature:"Mickael Lallart",coverURL:"https://cdn.intechopen.com/books/images_new/2706.jpg",editedByType:"Edited by",editors:[{id:"10041",title:"Dr.",name:"Mickaël",surname:"Lallart",slug:"mickael-lallart",fullName:"Mickaël Lallart"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"115",title:"Wind Turbines",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"wind-turbines",bookSignature:"Ibrahim Al-Bahadly",coverURL:"https://cdn.intechopen.com/books/images_new/115.jpg",editedByType:"Edited by",editors:[{id:"19588",title:"Dr.",name:"Ibrahim H.",surname:"Al-Bahadly",slug:"ibrahim-h.-al-bahadly",fullName:"Ibrahim H. Al-Bahadly"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"427",title:"Sustainable Energy Harvesting Technologies",subtitle:"Past, Present and Future",isOpenForSubmission:!1,hash:"61a870ec0f3bf63739132a7cf4465ca7",slug:"sustainable-energy-harvesting-technologies-past-present-and-future",bookSignature:"Yen Kheng Tan",coverURL:"https://cdn.intechopen.com/books/images_new/427.jpg",editedByType:"Edited by",editors:[{id:"78857",title:"Dr.",name:"Tan Yen",surname:"Kheng",slug:"tan-yen-kheng",fullName:"Tan Yen Kheng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"13",title:"Paths to Sustainable Energy",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"paths-to-sustainable-energy",bookSignature:"Jatin Nathwani and Artie Ng",coverURL:"https://cdn.intechopen.com/books/images_new/13.jpg",editedByType:"Edited by",editors:[{id:"13730",title:"Dr.",name:"Artie",surname:"Ng",slug:"artie-ng",fullName:"Artie Ng"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"212",title:"Energy Storage in the Emerging Era of Smart Grids",subtitle:null,isOpenForSubmission:!1,hash:"8cd6021285906516c727802d02ce0954",slug:"energy-storage-in-the-emerging-era-of-smart-grids",bookSignature:"Rosario Carbone",coverURL:"https://cdn.intechopen.com/books/images_new/212.jpg",editedByType:"Edited by",editors:[{id:"11592",title:"Prof.",name:"Rosario",surname:"Carbone",slug:"rosario-carbone",fullName:"Rosario Carbone"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2763",title:"Gasification for Practical Applications",subtitle:null,isOpenForSubmission:!1,hash:"e576b2a136c1c20c784302344c65448e",slug:"gasification-for-practical-applications",bookSignature:"Yongseung Yun",coverURL:"https://cdn.intechopen.com/books/images_new/2763.jpg",editedByType:"Edited by",editors:[{id:"144925",title:"Dr.",name:"Yongseung",surname:"Yun",slug:"yongseung-yun",fullName:"Yongseung Yun"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5440",title:"Composites from Renewable and Sustainable Materials",subtitle:null,isOpenForSubmission:!1,hash:"73daa2bb2ab6395c43f1a830aa6223ad",slug:"composites-from-renewable-and-sustainable-materials",bookSignature:"Matheus Poletto",coverURL:"https://cdn.intechopen.com/books/images_new/5440.jpg",editedByType:"Edited by",editors:[{id:"140017",title:"Dr.",name:"Matheus",surname:"Poletto",slug:"matheus-poletto",fullName:"Matheus Poletto"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"148",title:"Wind Farm",subtitle:"Technical Regulations, Potential Estimation and Siting Assessment",isOpenForSubmission:!1,hash:"f7a3aafd9530aba9911c69ec17d31673",slug:"wind-farm-technical-regulations-potential-estimation-and-siting-assessment",bookSignature:"Gastón O. Suvire",coverURL:"https://cdn.intechopen.com/books/images_new/148.jpg",editedByType:"Edited by",editors:[{id:"12698",title:"Dr.",name:"Gastón Orlando",surname:"Suvire",slug:"gaston-orlando-suvire",fullName:"Gastón Orlando Suvire"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3672",title:"Energy Efficiency",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"energy-efficiency",bookSignature:"Jenny Palm",coverURL:"https://cdn.intechopen.com/books/images_new/3672.jpg",editedByType:"Edited by",editors:[{id:"10812",title:"Prof.",name:"Jenny",surname:"Palm",slug:"jenny-palm",fullName:"Jenny Palm"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"79356",slug:"corrigendum-the-ghanaian-flora-as-a-potential-source-of-anthelmintic-and-anti-schistosomal-agents",title:"Corrigendum: The Ghanaian Flora as a Potential Source of Anthelmintic and Anti-Schistosomal Agents",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/76505.pdf\r\n",downloadPdfUrl:"/chapter/pdf-download/76505",previewPdfUrl:"/chapter/pdf-preview/76505",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/76505",risUrl:"/chapter/ris/76505",chapter:{id:"76353",slug:"the-ghanaian-flora-as-a-potential-source-of-anthelmintic-and-anti-schistosomal-agents",signatures:"Evelyn Asante-Kwatia, Abraham Yeboah Mensah, Lord Gyimah and Arnold Donkor Forkuo",dateSubmitted:"February 24th 2021",dateReviewed:"March 25th 2021",datePrePublished:"April 20th 2021",datePublished:"May 11th 2022",book:{id:"10356",title:"Natural Medicinal Plants",subtitle:null,fullTitle:"Natural Medicinal Plants",slug:"natural-medicinal-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"217045",title:"Dr.",name:"Arnold Forkuo",middleName:null,surname:"Donkor",fullName:"Arnold Forkuo Donkor",slug:"arnold-forkuo-donkor",email:"forkuo3@gmail.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}},{id:"303360",title:"Dr.",name:"Evelyn",middleName:null,surname:"Asante-Kwatia",fullName:"Evelyn Asante-Kwatia",slug:"evelyn-asante-kwatia",email:"emireku@yahoo.com",position:null,institution:null},{id:"309974",title:"Prof.",name:"Abraham Yeboah",middleName:null,surname:"Mensah",fullName:"Abraham Yeboah Mensah",slug:"abraham-yeboah-mensah",email:"aymensah@yahoo.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}},{id:"347910",title:"Mr.",name:"Lord",middleName:null,surname:"Gyimah",fullName:"Lord Gyimah",slug:"lord-gyimah",email:"lordgyimah36@gmail.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}}]}},chapter:{id:"76353",slug:"the-ghanaian-flora-as-a-potential-source-of-anthelmintic-and-anti-schistosomal-agents",signatures:"Evelyn Asante-Kwatia, Abraham Yeboah Mensah, Lord Gyimah and Arnold Donkor Forkuo",dateSubmitted:"February 24th 2021",dateReviewed:"March 25th 2021",datePrePublished:"April 20th 2021",datePublished:"May 11th 2022",book:{id:"10356",title:"Natural Medicinal Plants",subtitle:null,fullTitle:"Natural Medicinal Plants",slug:"natural-medicinal-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"217045",title:"Dr.",name:"Arnold Forkuo",middleName:null,surname:"Donkor",fullName:"Arnold Forkuo Donkor",slug:"arnold-forkuo-donkor",email:"forkuo3@gmail.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}},{id:"303360",title:"Dr.",name:"Evelyn",middleName:null,surname:"Asante-Kwatia",fullName:"Evelyn Asante-Kwatia",slug:"evelyn-asante-kwatia",email:"emireku@yahoo.com",position:null,institution:null},{id:"309974",title:"Prof.",name:"Abraham Yeboah",middleName:null,surname:"Mensah",fullName:"Abraham Yeboah Mensah",slug:"abraham-yeboah-mensah",email:"aymensah@yahoo.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}},{id:"347910",title:"Mr.",name:"Lord",middleName:null,surname:"Gyimah",fullName:"Lord Gyimah",slug:"lord-gyimah",email:"lordgyimah36@gmail.com",position:null,institution:{name:"Kwame Nkrumah University of Science and Technology",institutionURL:null,country:{name:"Ghana"}}}]},book:{id:"10356",title:"Natural Medicinal Plants",subtitle:null,fullTitle:"Natural Medicinal Plants",slug:"natural-medicinal-plants",publishedDate:"May 11th 2022",bookSignature:"Hany A. El-Shemy",coverURL:"https://cdn.intechopen.com/books/images_new/10356.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",editors:[{id:"54719",title:"Prof.",name:"Hany",middleName:null,surname:"El-Shemy",slug:"hany-el-shemy",fullName:"Hany El-Shemy"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11920",leadTitle:null,title:"Updates on Software Usability",subtitle:null,reviewType:"peer-reviewed",abstract:"
\r\n\tSoftware Usability should be central to any software development, especially when it comes to software that is going to be used by people. Software Usability goes far beyond functional testing, also.
\r\n\r\n\tIn this book, we set up to put together a collection of high-quality contributions that can help and inspire academics and practitioners alike. We aim to focus on three key areas: testing, scalability, and security. We refer to software usability testing as a key activity to both define, validate and verify software usability properties of applications and systems. We refer to software usability scalability both in terms of user scale and data scale. Last but not least, we refer to software usability security in terms of privacy and safety.
\r\n\r\n\tWith these drivers, our intention with this book is to deliver novel research and experiences. The chapters of this volume are also expected to be approachable by the general population.
",isbn:"978-1-80356-636-8",printIsbn:"978-1-80356-635-1",pdfIsbn:"978-1-80356-637-5",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"7ef0f460b3bdd82015ead5fcca9f73f0",bookSignature:"Dr. Laura M. M. Castro",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11920.jpg",keywords:"Usability Testing, Testing Methods, Testing Standards, User-Centered Testing, Automated Testing, Software Development, High-Scale Testing, User-Intensive Systems, Data-Intensive Systems, Software Usability, Privacy, Intrusion",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 17th 2022",dateEndSecondStepPublish:"May 24th 2022",dateEndThirdStepPublish:"July 23rd 2022",dateEndFourthStepPublish:"October 11th 2022",dateEndFifthStepPublish:"December 10th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Castro is a professor and lead researcher at the University of A Coruña (Spain). She is actively involved in dissemination activities, in particular the visibility of women in STEM, as a member of the Association for Computing Machinery's Council on Women in Computing (ACM-W) Europe.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"151757",title:"Dr.",name:"Laura M.",middleName:"M.",surname:"Castro",slug:"laura-m.-castro",fullName:"Laura M. Castro",profilePictureURL:"https://mts.intechopen.com/storage/users/151757/images/system/151757.jpg",biography:"Dr. Laura M. Castro is a professor at the University of A Coruña, Spain, where she has been lecturing for fifteen years. She is currently the studies coordinator for the degree in Software Engineering at the same university and is responsible for several courses on Software Architecture and Software Testing. Her most recent research interests focus on the automatic validation of distributed systems. She has supervised three Ph.D. theses and acted as PI in several European projects. She is also actively involved in dissemination activities, in particular the visibility of women in STEM, as a member of the Association for Computing Machinery\\'s Council on Women in Computing (ACM-W) Europe.",institutionString:"University of A Coruña",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"University of A Coruña",institutionURL:null,country:{name:"Spain"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"9",title:"Computer and Information Science",slug:"computer-and-information-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"453623",firstName:"Silvia",lastName:"Sabo",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/453623/images/20396_n.jpg",email:"silvia@intechopen.com",biography:null}},relatedBooks:[{type:"book",id:"10271",title:"Software Usability",subtitle:null,isOpenForSubmission:!1,hash:"8c71aff43977a455e7563255a2c104b1",slug:"software-usability",bookSignature:"Laura M. Castro, David Cabrero and Rüdiger Heimgärtner",coverURL:"https://cdn.intechopen.com/books/images_new/10271.jpg",editedByType:"Edited by",editors:[{id:"151757",title:"Dr.",name:"Laura M.",surname:"Castro",slug:"laura-m.-castro",fullName:"Laura M. Castro"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3828",title:"Application of Nanotechnology in Drug Delivery",subtitle:null,isOpenForSubmission:!1,hash:"51a27e7adbfafcfedb6e9683f209cba4",slug:"application-of-nanotechnology-in-drug-delivery",bookSignature:"Ali Demir Sezer",coverURL:"https://cdn.intechopen.com/books/images_new/3828.jpg",editedByType:"Edited by",editors:[{id:"62389",title:"PhD.",name:"Ali Demir",surname:"Sezer",slug:"ali-demir-sezer",fullName:"Ali Demir Sezer"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"872",title:"Organic Pollutants Ten Years After the Stockholm Convention",subtitle:"Environmental and Analytical Update",isOpenForSubmission:!1,hash:"f01dc7077e1d23f3d8f5454985cafa0a",slug:"organic-pollutants-ten-years-after-the-stockholm-convention-environmental-and-analytical-update",bookSignature:"Tomasz Puzyn and Aleksandra Mostrag-Szlichtyng",coverURL:"https://cdn.intechopen.com/books/images_new/872.jpg",editedByType:"Edited by",editors:[{id:"84887",title:"Dr.",name:"Tomasz",surname:"Puzyn",slug:"tomasz-puzyn",fullName:"Tomasz Puzyn"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"30812",title:"Ecohydrology and Biogeochemistry in a Temperate Forest Catchment",doi:"10.5772/30759",slug:"ecohydrology-and-biogeochemistry-in-a-temperate-forest-catchment",body:null,keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/30812.pdf",chapterXML:null,downloadPdfUrl:"/chapter/pdf-download/30812",previewPdfUrl:"/chapter/pdf-preview/30812",totalDownloads:2748,totalViews:106,totalCrossrefCites:0,totalDimensionsCites:1,totalAltmetricsMentions:0,introChapter:null,impactScore:0,impactScorePercentile:26,impactScoreQuartile:2,hasAltmetrics:0,dateSubmitted:"March 23rd 2011",dateReviewed:"August 24th 2011",datePrePublished:null,datePublished:"March 7th 2012",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/30812",risUrl:"/chapter/ris/30812",book:{id:"616",slug:"forest-ecosystems-more-than-just-trees"},signatures:"Su-Jin Kim, Hyung Tae Choi, Kyongha Kim and Chunghwa Lee",authors:[{id:"84108",title:"Dr.",name:"Su-Jin",middleName:null,surname:"Kim",fullName:"Su-Jin Kim",slug:"su-jin-kim",email:"kimsj@forest.go.kr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Korea Food Research Institute",institutionURL:null,country:{name:"Korea, South"}}},{id:"87060",title:"Dr.",name:"Hyung Tae",middleName:null,surname:"Choi",fullName:"Hyung Tae Choi",slug:"hyung-tae-choi",email:"choih@forest.go.kr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Korea Food Research Institute",institutionURL:null,country:{name:"Korea, South"}}},{id:"87062",title:"Dr.",name:"Kyongha",middleName:null,surname:"Kim",fullName:"Kyongha Kim",slug:"kyongha-kim",email:"kkyha@forest.go.kr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:{name:"Korea Food Research Institute",institutionURL:null,country:{name:"Korea, South"}}},{id:"124618",title:"Dr.",name:"Chunghwa",middleName:null,surname:"Lee",fullName:"Chunghwa Lee",slug:"chunghwa-lee",email:"hwa21@forest.go.kr",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:null,chapterReferences:null,footnotes:null,contributors:null,corrections:null},book:{id:"616",type:"book",title:"Forest Ecosystems",subtitle:"More than Just Trees",fullTitle:"Forest Ecosystems - More than Just Trees",slug:"forest-ecosystems-more-than-just-trees",publishedDate:"March 7th 2012",bookSignature:"Juan A. Blanco and Yueh-Hsin Lo",coverURL:"https://cdn.intechopen.com/books/images_new/616.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:null,printIsbn:"978-953-51-0202-1",pdfIsbn:"978-953-51-5230-9",reviewType:"peer-reviewed",numberOfWosCitations:104,isAvailableForWebshopOrdering:!0,editors:[{id:"51995",title:"Dr.",name:"Juan",middleName:"A.",surname:"Blanco",slug:"juan-blanco",fullName:"Juan Blanco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"61070",title:"Dr.",name:"Yueh-Hsin",middleName:null,surname:"Lo",slug:"yueh-hsin-lo",fullName:"Yueh-Hsin Lo"},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"331"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"30805",type:"chapter",title:"Plant Diversity of Forests",slug:"plant-diversity-of-forests",totalDownloads:4863,totalCrossrefCites:3,signatures:"Ján Merganič, Katarína Merganičová, Róbert Marušák and Vendula Audolenská",reviewType:"peer-reviewed",authors:[{id:"85174",title:"Dr.",name:"Katarina",middleName:null,surname:"Merganičová",fullName:"Katarina Merganičová",slug:"katarina-merganicova"},{id:"88588",title:"Prof.",name:"Ján",middleName:null,surname:"Merganič",fullName:"Ján Merganič",slug:"jan-merganic"},{id:"89509",title:"Prof.",name:"Róbert",middleName:null,surname:"Marušák",fullName:"Róbert Marušák",slug:"robert-marusak"},{id:"124838",title:"MSc.",name:"Vendula",middleName:null,surname:"Audolenská",fullName:"Vendula Audolenská",slug:"vendula-audolenska"}]},{id:"30806",type:"chapter",title:"Arthropods and Nematodes: Functional Biodiversity in Forest Ecosystems",slug:"arthropods-and-nematodes-functional-biodiversity-in-forest-ecosystems",totalDownloads:3181,totalCrossrefCites:0,signatures:"Pio Federico Roversi and Roberto Nannelli",reviewType:"peer-reviewed",authors:[{id:"86246",title:"Dr.",name:"Pio Federico",middleName:null,surname:"Roversi",fullName:"Pio Federico Roversi",slug:"pio-federico-roversi"},{id:"86555",title:"Dr",name:"Roberto",middleName:null,surname:"Nannelli",fullName:"Roberto Nannelli",slug:"roberto-nannelli"}]},{id:"30807",type:"chapter",title:"Advances in Molecular Diversity of Arbuscular Mycorrhizal Fungi (Phylum Glomeromycota) in Forest Ecosystems",slug:"advances-in-molecular-diversity-of-arbuscular-mycorrhizal-fungi-phylum-glomeromycota-in-forest-ecosy",totalDownloads:4372,totalCrossrefCites:0,signatures:"Camila Maistro Patreze, Milene Moreira and Siu Mui Tsai",reviewType:"peer-reviewed",authors:[{id:"90489",title:"Prof.",name:"Siu Mui",middleName:null,surname:"Tsai",fullName:"Siu Mui Tsai",slug:"siu-mui-tsai"},{id:"151169",title:"Dr.",name:"Camila",middleName:null,surname:"Patreze",fullName:"Camila Patreze",slug:"camila-patreze"}]},{id:"30808",type:"chapter",title:"Deadwood in Forest Ecosystems",slug:"deadwood",totalDownloads:4067,totalCrossrefCites:12,signatures:"Katarína Merganičová, Ján Merganič, Miroslav Svoboda, Radek Bače and Vladimír Šebeň",reviewType:"peer-reviewed",authors:[{id:"85174",title:"Dr.",name:"Katarina",middleName:null,surname:"Merganičová",fullName:"Katarina Merganičová",slug:"katarina-merganicova"},{id:"88588",title:"Prof.",name:"Ján",middleName:null,surname:"Merganič",fullName:"Ján Merganič",slug:"jan-merganic"},{id:"88589",title:"Prof.",name:"Miroslav",middleName:null,surname:"Svoboda",fullName:"Miroslav Svoboda",slug:"miroslav-svoboda"},{id:"88591",title:"MSc.",name:"Radek",middleName:null,surname:"Bače",fullName:"Radek Bače",slug:"radek-bace"},{id:"89317",title:"Dr.",name:"Vladimír",middleName:null,surname:"Šebeň",fullName:"Vladimír Šebeň",slug:"vladimir-seben"}]},{id:"30809",type:"chapter",title:"Composition and Stand Structure of Tropical Moist Deciduous Forest of Similipal Biosphere Reserve, Orissa, India",slug:"stand-structure-of-tropical-moist-deciduous-forest-of-similipal-biosphere-reserve-orissa-india",totalDownloads:4343,totalCrossrefCites:2,signatures:"R.K. Mishra, V.P. Upadhyay, P.K. Nayak, S. Pattanaik and R.C. Mohanty",reviewType:"peer-reviewed",authors:[{id:"89342",title:"Dr.",name:"Rabindra",middleName:null,surname:"Mishra",fullName:"Rabindra Mishra",slug:"rabindra-mishra"}]},{id:"30810",type:"chapter",title:"Vegetation Evolution in the Mountains of Cameroon During the Last 20 000 Years: Pollen Analysis of Lake Bambili Sediments",slug:"ecosystem-dynamics-and-biodiversity-of-the-cameroon-mountains-during-the-last-20-000-years-pollen-an",totalDownloads:3038,totalCrossrefCites:2,signatures:"Chimène Assi-Kaudjhis",reviewType:"peer-reviewed",authors:[{id:"81112",title:"Dr.",name:"Chimène",middleName:null,surname:"Assi-Kaudjhis",fullName:"Chimène Assi-Kaudjhis",slug:"chimene-assi-kaudjhis"}]},{id:"30811",type:"chapter",title:"Using Remotely Sensed Imagery for Forest Resource Assessment and Inventory",slug:"using-remotely-sensed-imagery-for-forest-resource-assessment-and-inventory",totalDownloads:4061,totalCrossrefCites:0,signatures:"Rodolfo Martinez Morales",reviewType:"peer-reviewed",authors:[{id:"81058",title:"Dr.",name:"Rodolfo",middleName:null,surname:"Martinez Morales",fullName:"Rodolfo Martinez Morales",slug:"rodolfo-martinez-morales"}]},{id:"30812",type:"chapter",title:"Ecohydrology and Biogeochemistry in a Temperate Forest Catchment",slug:"ecohydrology-and-biogeochemistry-in-a-temperate-forest-catchment",totalDownloads:2748,totalCrossrefCites:0,signatures:"Su-Jin Kim, Hyung Tae Choi, Kyongha Kim and Chunghwa Lee",reviewType:"peer-reviewed",authors:[{id:"84108",title:"Dr.",name:"Su-Jin",middleName:null,surname:"Kim",fullName:"Su-Jin Kim",slug:"su-jin-kim"},{id:"87060",title:"Dr.",name:"Hyung Tae",middleName:null,surname:"Choi",fullName:"Hyung Tae Choi",slug:"hyung-tae-choi"},{id:"87062",title:"Dr.",name:"Kyongha",middleName:null,surname:"Kim",fullName:"Kyongha Kim",slug:"kyongha-kim"},{id:"124618",title:"Dr.",name:"Chunghwa",middleName:null,surname:"Lee",fullName:"Chunghwa Lee",slug:"chunghwa-lee"}]},{id:"30813",type:"chapter",title:"Carbon Cycling in Teak Plantations in Comparison with Seasonally Dry Tropical Forests in Thailand",slug:"carbon-cycling-in-teak-plantations-in-comparison-with-seasonally-dry-tropical-forests-in-thailand",totalDownloads:4835,totalCrossrefCites:5,signatures:"Masamichi Takahashi, Dokrak Marod, Samreong Panuthai and Keizo Hirai",reviewType:"peer-reviewed",authors:[{id:"81311",title:"Dr.",name:"Masamichi",middleName:null,surname:"Takahashi",fullName:"Masamichi Takahashi",slug:"masamichi-takahashi"},{id:"89112",title:"Prof.",name:"Dokrak",middleName:null,surname:"Marod",fullName:"Dokrak Marod",slug:"dokrak-marod"},{id:"125863",title:"Dr.",name:"Keizo",middleName:null,surname:"Hirai",fullName:"Keizo Hirai",slug:"keizo-hirai"},{id:"125865",title:"Dr.",name:"Samreong",middleName:null,surname:"Panuthai",fullName:"Samreong Panuthai",slug:"samreong-panuthai"}]},{id:"30814",type:"chapter",title:"Fertility, Microbial Biomass and Edaphic Fauna Under Forestry and Agroforestry Systems in the Eastern Amazon",slug:"fertility-microbial-biomass-and-edaphic-fauna-under-forestry-and-agroforestry-systems-in-the-eastern",totalDownloads:2827,totalCrossrefCites:0,signatures:"Maria de Lourdes Pinheiro Ruivo, Antonio Pereira Junior, Keila Chistina Bernardes, Cristine Bastos Amarante, Quezia Leandro Moura and Maria Lucia Jardim Macambira",reviewType:"peer-reviewed",authors:[{id:"78933",title:"Dr.",name:"Maria",middleName:null,surname:"De Lourdes Pinheiro Ruivo",fullName:"Maria De Lourdes Pinheiro Ruivo",slug:"maria-de-lourdes-pinheiro-ruivo"},{id:"78948",title:"MSc",name:"Antonio",middleName:"Pereira",surname:"Pereira Junior",fullName:"Antonio Pereira Junior",slug:"antonio-pereira-junior"},{id:"78949",title:"Dr.",name:"Maria",middleName:null,surname:"Lucia Jardim Macambira",fullName:"Maria Lucia Jardim Macambira",slug:"maria-lucia-jardim-macambira"},{id:"78951",title:"MSc.",name:"Keila",middleName:null,surname:"Chistina Bernardes",fullName:"Keila Chistina Bernardes",slug:"keila-chistina-bernardes"},{id:"78954",title:"Prof.",name:"Quezia",middleName:null,surname:"Leandro Moura",fullName:"Quezia Leandro Moura",slug:"quezia-leandro-moura"},{id:"124672",title:"Dr.",name:"Cristine",middleName:null,surname:"Bastos Amarante",fullName:"Cristine Bastos Amarante",slug:"cristine-bastos-amarante"}]},{id:"30815",type:"chapter",title:"Plant Productivity is Temporally Enhanced by Soil Fauna Depending on the Life Stage and Abundance of Animals",slug:"plant-productivity-is-temporally-enhanced-by-soil-fauna-depending-on-the-life-stage-and-abundance-of",totalDownloads:2356,totalCrossrefCites:0,signatures:"Ayu Toyota and Nobuhiro Kaneko",reviewType:"peer-reviewed",authors:[{id:"87835",title:"Dr.",name:"Ayu",middleName:null,surname:"Toyota",fullName:"Ayu Toyota",slug:"ayu-toyota"},{id:"124811",title:"Prof.",name:"Nobuhiro",middleName:null,surname:"Kaneko",fullName:"Nobuhiro Kaneko",slug:"nobuhiro-kaneko"}]},{id:"30816",type:"chapter",title:"Entomopathogenic Fungi as an Important Natural Regulator of Insect Outbreaks in Forests (Review)",slug:"entomopathogenic-fungi-as-an-important-natural-regulator-of-insect-outbreaks-in-forests-review-",totalDownloads:6721,totalCrossrefCites:12,signatures:"Anna Augustyniuk-Kram and Karol J. Kram",reviewType:"peer-reviewed",authors:[{id:"83229",title:"Dr.",name:"Karol",middleName:"J.",surname:"Kram",fullName:"Karol Kram",slug:"karol-kram"},{id:"87728",title:"Dr.",name:"Anna",middleName:null,surname:"Augustyniuk-Kram",fullName:"Anna Augustyniuk-Kram",slug:"anna-augustyniuk-kram"}]},{id:"30817",type:"chapter",title:"Quantitative Chemical Defense Traits, Litter Decomposition and Forest Ecosystem Functioning",slug:"quantitative-chemical-defense-traits-litter-decomposition-and-forest-ecosystem-functioning",totalDownloads:3513,totalCrossrefCites:1,signatures:"Mohammed Mahabubur Rahman and Rahman Md. Motiur",reviewType:"peer-reviewed",authors:[{id:"127649",title:"Dr.",name:"Mohammed",middleName:"Mahabubur",surname:"Rahman",fullName:"Mohammed Rahman",slug:"mohammed-rahman"},{id:"127706",title:"Dr.",name:"Md. Motiur",middleName:null,surname:"Rahman",fullName:"Md. Motiur Rahman",slug:"md.-motiur-rahman"}]},{id:"30818",type:"chapter",title:"Genetic Sustainability of Fragmented Conifer Populations from Stressed Areas in Northern Ontario (Canada): Application of Molecular Markers",slug:"sustainability-of-spruce-and-pine-populations-from-stressed-areas-in-northern-ontario-canada-",totalDownloads:2860,totalCrossrefCites:0,signatures:"K.K. Nkongolo, R. Narendrula, M. Mehes-Smith, S. Dobrzeniecka, K. Vandeligt, M. Ranger and P. Beckett",reviewType:"peer-reviewed",authors:[{id:"78238",title:"Prof.",name:"Kabwe",middleName:null,surname:"Nkongolo",fullName:"Kabwe Nkongolo",slug:"kabwe-nkongolo"},{id:"79019",title:"Dr.",name:"Melanie",middleName:null,surname:"Mehes-Smith",fullName:"Melanie Mehes-Smith",slug:"melanie-mehes-smith"},{id:"79022",title:"MSc",name:"Ramya",middleName:null,surname:"Narendrula",fullName:"Ramya Narendrula",slug:"ramya-narendrula"}]},{id:"30819",type:"chapter",title:"Moving from Ecological Conservation to Restoration: An Example from Central Taiwan, Asia",slug:"moving-from-ecological-conservation-to-restoration-an-example-from-central-taiwan-asia",totalDownloads:2710,totalCrossrefCites:2,signatures:"Yueh-Hsin Lo, Yi-Ching Lin, Juan A. Blanco, Chih-Wei Yu and Biing T. Guan",reviewType:"peer-reviewed",authors:[{id:"51995",title:"Dr.",name:"Juan",middleName:"A.",surname:"Blanco",fullName:"Juan Blanco",slug:"juan-blanco"},{id:"61070",title:"Dr.",name:"Yueh-Hsin",middleName:null,surname:"Lo",fullName:"Yueh-Hsin Lo",slug:"yueh-hsin-lo"},{id:"121412",title:"Prof.",name:"Biing T.",middleName:null,surname:"Guan",fullName:"Biing T. Guan",slug:"biing-t.-guan"},{id:"121413",title:"Dr.",name:"Yi-Ching",middleName:null,surname:"Li",fullName:"Yi-Ching Li",slug:"yi-ching-li"},{id:"121903",title:"MSc.",name:"Chih-Wei",middleName:null,surname:"Yu",fullName:"Chih-Wei Yu",slug:"chih-wei-yu"}]},{id:"30820",type:"chapter",title:"Restoration of Forest Ecosystems on Disturbed Lands on the Northern Forest Distribution Border (North-East of European Russia)",slug:"restoration-of-forest-ecosystems-on-disturbed-lands-on-the-northern-forest-distribution-border-north",totalDownloads:2631,totalCrossrefCites:0,signatures:"Irina Likhanova and Inna Archegova",reviewType:"peer-reviewed",authors:[{id:"89124",title:"Dr.",name:"Irina",middleName:null,surname:"Likhanova",fullName:"Irina Likhanova",slug:"irina-likhanova"},{id:"89138",title:"Dr.",name:"Inna",middleName:null,surname:"Archegova",fullName:"Inna Archegova",slug:"inna-archegova"}]},{id:"30821",type:"chapter",title:"Close to Nature Management in High-Mountain Forests of Norway Spruce Vegetation Zone in Slovakia",slug:"close-to-nature-management-in-high-mountain-forests-of-norway-spruce-vegetation-zone-in-slovakia",totalDownloads:2863,totalCrossrefCites:0,signatures:"Martin Moravčík, Zuzana Sarvašová, Ján Merganič and Miroslav Kovalčík",reviewType:"peer-reviewed",authors:[{id:"88181",title:"Dr.",name:"Zuzana",middleName:null,surname:"Sarvasova",fullName:"Zuzana Sarvasova",slug:"zuzana-sarvasova"},{id:"88226",title:"Dr.",name:"Martin",middleName:null,surname:"Moravčík",fullName:"Martin Moravčík",slug:"martin-moravcik"},{id:"126678",title:"Dr.",name:"Miroslav",middleName:null,surname:"Kovalčík",fullName:"Miroslav Kovalčík",slug:"miroslav-kovalcik"},{id:"126681",title:"Dr.",name:"Ján",middleName:null,surname:"Merganič",fullName:"Ján Merganič",slug:"jan-merganic"}]},{id:"30822",type:"chapter",title:"Interactions of Forest Road, Forest Harvesting and Forest Ecosystems",slug:"interactions-of-forest-road-forest-harvesting-and-forest-ecosystems",totalDownloads:3177,totalCrossrefCites:3,signatures:"Murat Demir",reviewType:"peer-reviewed",authors:[{id:"80947",title:"Dr.",name:"Murat",middleName:null,surname:"Demir",fullName:"Murat Demir",slug:"murat-demir"}]},{id:"30823",type:"chapter",title:"Forest Transportation Systems as a Key Factor in Quality Management of Forest Ecosystems",slug:"forest-transportation-systems-as-a-key-factor-in-quality-management-of-forest-ecosystems",totalDownloads:2361,totalCrossrefCites:1,signatures:"Tibor Pentek and Tomislav Poršinsky",reviewType:"peer-reviewed",authors:[{id:"83078",title:"Prof.",name:"Tibor",middleName:null,surname:"Pentek",fullName:"Tibor Pentek",slug:"tibor-pentek"},{id:"88732",title:"Prof.",name:"Tomislav",middleName:null,surname:"Poršinsky",fullName:"Tomislav Poršinsky",slug:"tomislav-porsinsky"}]}]},relatedBooks:[{type:"book",id:"4483",title:"Biodiversity in Ecosystems",subtitle:"Linking Structure and Function",isOpenForSubmission:!1,hash:"d488928dfd93614e6a94950be7131fa0",slug:"biodiversity-in-ecosystems-linking-structure-and-function",bookSignature:"Yueh-Hsin Lo, Juan A. Blanco and Shovonlal Roy",coverURL:"https://cdn.intechopen.com/books/images_new/4483.jpg",editedByType:"Edited by",editors:[{id:"51995",title:"Dr.",name:"Juan",surname:"Blanco",slug:"juan-blanco",fullName:"Juan Blanco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"},chapters:[{id:"47509",title:"Importance of Allelopathy as Peudo-Mixotrophy for the Dynamics and Diversity of Phytoplankton",slug:"importance-of-allelopathy-as-peudo-mixotrophy-for-the-dynamics-and-diversity-of-phytoplankton",signatures:"Roy Shovonlal",authors:[{id:"171157",title:"Prof.",name:"Shovonlal",middleName:null,surname:"Roy",fullName:"Shovonlal Roy",slug:"shovonlal-roy"}]},{id:"47598",title:"Functional Redundancy and Ecosystem Function — The Soil Microbiota as a Case Study",slug:"functional-redundancy-and-ecosystem-function-the-soil-microbiota-as-a-case-study",signatures:"Stephanie D. Jurburg and Joana Falcão Salles",authors:[{id:"171037",title:"Dr.",name:"Joana",middleName:null,surname:"Falcão Salles",fullName:"Joana Falcão Salles",slug:"joana-falcao-salles"},{id:"171303",title:"Ms.",name:"Stephanie",middleName:null,surname:"Jurburg",fullName:"Stephanie Jurburg",slug:"stephanie-jurburg"}]},{id:"47668",title:"Biodiversity and Ecosystem Functioning in Tropical Habitats — Case Studies and Future Perspectives in Atlantic Rainforest and Cerrado Landscapes",slug:"biodiversity-and-ecosystem-functioning-in-tropical-habitats-case-studies-and-future-perspectives-in-",signatures:"Tathiana G. Sobrinho, Lucas N. Paolucci, Dalana C. Muscardi,\nAna C. Maradini, Elisangela A. Silva, Ricardo R. C. Solar and\nJosé H. Schoereder",authors:[{id:"50115",title:"Prof.",name:"Jose",middleName:null,surname:"Schoereder",fullName:"Jose Schoereder",slug:"jose-schoereder"}]},{id:"47656",title:"Climate Change, Range Shifts and Multitrophic Interactions",slug:"climate-change-range-shifts-and-multitrophic-interactions",signatures:"Jeffrey A. Harvey and Miriama Malcicka",authors:[{id:"171184",title:"Dr.",name:"Jeff",middleName:null,surname:"Harvey",fullName:"Jeff Harvey",slug:"jeff-harvey"},{id:"172779",title:"MSc.",name:"Miriama",middleName:null,surname:"Malcicka",fullName:"Miriama Malcicka",slug:"miriama-malcicka"}]},{id:"47711",title:"Responding to Change — Criteria and Indicators for Managing the Transformation of Vegetated Landscapes to Maintain or Restore Ecosystem Diversity",slug:"responding-to-change-criteria-and-indicators-for-managing-the-transformation-of-vegetated-landscapes",signatures:"Graham A. Yapp and Richard Thackway",authors:[{id:"171086",title:"Dr.",name:"Graham",middleName:null,surname:"Yapp",fullName:"Graham Yapp",slug:"graham-yapp"},{id:"171613",title:"Associate Prof.",name:"Richard",middleName:"Malcolm",surname:"Thackway",fullName:"Richard Thackway",slug:"richard-thackway"}]},{id:"47653",title:"Maintaining Ecosystem Function by Restoring Forest Biodiversity – Reviewing Decision-Support Tools that link Biology, Hydrology and Geochemistry",slug:"maintaining-ecosystem-function-by-restoring-forest-biodiversity-reviewing-decision-support-tools-tha",signatures:"Yueh-Hsin Lo, Juan A. Blanco, Clive Welham and Mike Wang",authors:[{id:"51995",title:"Dr.",name:"Juan",middleName:"A.",surname:"Blanco",fullName:"Juan Blanco",slug:"juan-blanco"},{id:"76276",title:"Dr.",name:"Clive",middleName:null,surname:"Welham",fullName:"Clive Welham",slug:"clive-welham"},{id:"171181",title:"Dr.",name:"Yueh-Hsin",middleName:null,surname:"Lo",fullName:"Yueh-Hsin Lo",slug:"yueh-hsin-lo"},{id:"173318",title:"Dr.",name:"Mike",middleName:null,surname:"Wang",fullName:"Mike Wang",slug:"mike-wang"}]},{id:"47477",title:"Microbial Assembly in Agroecosystems — From the Small Arise the Big",slug:"microbial-assembly-in-agroecosystems-from-the-small-arise-the-big",signatures:"Dennis Goss de Souza, Lucas William Mendes, Acácio Aparecido\nNavarrete and Siu Mui Tsai",authors:[{id:"90489",title:"Prof.",name:"Siu Mui",middleName:null,surname:"Tsai",fullName:"Siu Mui Tsai",slug:"siu-mui-tsai"},{id:"171323",title:"MSc.",name:"Dennis",middleName:null,surname:"Goss Souza",fullName:"Dennis Goss Souza",slug:"dennis-goss-souza"},{id:"171324",title:"Dr.",name:"Lucas William",middleName:null,surname:"Mendes",fullName:"Lucas William Mendes",slug:"lucas-william-mendes"},{id:"171328",title:"Dr.",name:"Acácio Aparecido",middleName:null,surname:"Navarrete",fullName:"Acácio Aparecido Navarrete",slug:"acacio-aparecido-navarrete"}]},{id:"47462",title:"Impact of Organic Farming on Biodiversity",slug:"impact-of-organic-farming-on-biodiversity",signatures:"Martina Bavec and Franc Bavec",authors:[{id:"170270",title:"Prof.",name:"Franc",middleName:null,surname:"Bavec",fullName:"Franc Bavec",slug:"franc-bavec"},{id:"171257",title:"Prof.",name:"Martina",middleName:null,surname:"Bavec",fullName:"Martina Bavec",slug:"martina-bavec"}]},{id:"47520",title:"Hydromorphology and Biodiversity in Headwaters — An Eco- Faunistic Substrate Preference Assessment in Forest Springs of the German Subdued Mountains",slug:"hydromorphology-and-biodiversity-in-headwaters-an-eco-faunistic-substrate-preference-assessment-in-f",signatures:"Martin Reiss and Peter Chifflard",authors:[{id:"170976",title:"Dr.",name:"Martin",middleName:null,surname:"Reiss",fullName:"Martin Reiss",slug:"martin-reiss"},{id:"171269",title:"Prof.",name:"Peter",middleName:null,surname:"Chifflard",fullName:"Peter Chifflard",slug:"peter-chifflard"}]},{id:"47621",title:"Biodiversity and Conservation of Temporary Ponds — Assessment of the Conservation Status of “Veiga de Ponteliñares”, NW Spain (Natura 2000 Network), Using Freshwater Invertebrates",slug:"biodiversity-and-conservation-of-temporary-ponds-assessment-of-the-conservation-status-of-veiga-de-p",signatures:"Amaia Pérez-Bilbao, Cesar João Benetti and Josefina Garrido",authors:[{id:"60498",title:"Prof.",name:"Josefina",middleName:null,surname:"Garrido",fullName:"Josefina Garrido",slug:"josefina-garrido"},{id:"60557",title:"Dr.",name:"Amaia",middleName:null,surname:"Pérez-Bilbao",fullName:"Amaia Pérez-Bilbao",slug:"amaia-perez-bilbao"},{id:"60558",title:"Dr.",name:"Cesar",middleName:"Joao",surname:"Benetti",fullName:"Cesar Benetti",slug:"cesar-benetti"}]},{id:"47627",title:"A First Approach to Assess the Impact of Bottom Trawling Over Vulnerable Marine Ecosystems on the High Seas of the Southwest Atlantic",slug:"a-first-approach-to-assess-the-impact-of-bottom-trawling-over-vulnerable-marine-ecosystems-on-the-hi",signatures:"J. Portela, J. Cristobo, P. Ríos, J. Acosta, S. Parra, J.L. del Río, E. Tel,\nV. Polonio, A. Muñoz, T. Patrocinio, R. Vilela, M. Barba and P. Marín",authors:[{id:"100909",title:"B.Sc.",name:"Julio",middleName:null,surname:"Portela",fullName:"Julio Portela",slug:"julio-portela"},{id:"101804",title:"Dr.",name:"Juan",middleName:null,surname:"Acosta",fullName:"Juan Acosta",slug:"juan-acosta"},{id:"101806",title:"Dr.",name:"Javier",middleName:null,surname:"Cristobo",fullName:"Javier Cristobo",slug:"javier-cristobo"},{id:"101810",title:"Dr.",name:"Santiago",middleName:null,surname:"Parra",fullName:"Santiago Parra",slug:"santiago-parra"},{id:"101816",title:"BSc.",name:"Jose Luis",middleName:null,surname:"Del Rio",fullName:"Jose Luis Del Rio",slug:"jose-luis-del-rio"},{id:"102254",title:"Dr.",name:"Elena",middleName:null,surname:"Tel",fullName:"Elena Tel",slug:"elena-tel"},{id:"102260",title:"Dr.",name:"Pilar",middleName:null,surname:"Rios",fullName:"Pilar Rios",slug:"pilar-rios"},{id:"102262",title:"BSc.",name:"Maria",middleName:null,surname:"Barba",fullName:"Maria Barba",slug:"maria-barba"},{id:"127541",title:"BSc.",name:"Virginia",middleName:null,surname:"Polonio",fullName:"Virginia Polonio",slug:"virginia-polonio"},{id:"173179",title:"Dr.",name:"Araceli",middleName:null,surname:"Muñoz",fullName:"Araceli Muñoz",slug:"araceli-munoz"},{id:"173180",title:"Dr.",name:"Teodoro",middleName:null,surname:"Ibarrola",fullName:"Teodoro Ibarrola",slug:"teodoro-ibarrola"},{id:"173181",title:"Dr.",name:"Raul",middleName:null,surname:"Vilela",fullName:"Raul Vilela",slug:"raul-vilela"},{id:"173182",title:"Dr.",name:"Pedro",middleName:null,surname:"Marín",fullName:"Pedro Marín",slug:"pedro-marin"}]},{id:"47622",title:"Agrorural Ecosystem Effects on the Macroinvertebrate Assemblages of a Tropical River",slug:"agrorural-ecosystem-effects-on-the-macroinvertebrate-assemblages-of-a-tropical-river",signatures:"Bert Kohlmann, Alejandra Arroyo, Monika Springer\nand Danny Vásquez",authors:[{id:"58064",title:"Prof.",name:"Bert",middleName:null,surname:"Kohlmann",fullName:"Bert Kohlmann",slug:"bert-kohlmann"},{id:"171258",title:"Dr.",name:"Alejandra",middleName:null,surname:"Arroyo",fullName:"Alejandra Arroyo",slug:"alejandra-arroyo"},{id:"171259",title:"Dr.",name:"Monika",middleName:null,surname:"Springer",fullName:"Monika Springer",slug:"monika-springer"},{id:"171260",title:"Mr.",name:"Danny",middleName:null,surname:"Vásquez",fullName:"Danny Vásquez",slug:"danny-vasquez"}]},{id:"47599",title:"Ecohidrology and Nutrient Fluxes in Forest Ecosystems of Southern Chile",slug:"ecohidrology-and-nutrient-fluxes-in-forest-ecosystems-of-southern-chile",signatures:"Carlos E Oyarzún and Pedro Hervé-Fernandez",authors:[{id:"171093",title:"Dr.",name:"Carlos",middleName:null,surname:"Oyarzun",fullName:"Carlos Oyarzun",slug:"carlos-oyarzun"},{id:"172999",title:"Ph.D. Student",name:"Pedro",middleName:"A.",surname:"Hervé-Fernández",fullName:"Pedro Hervé-Fernández",slug:"pedro-herve-fernandez"}]},{id:"47726",title:"Ecological Flexibility of the Top Predator in an Island Ecosystem — The Iriomote Cat Changes Feeding Patterns in Relation to Prey Availability",slug:"ecological-flexibility-of-the-top-predator-in-an-island-ecosystem-the-iriomote-cat-changes-feeding-p",signatures:"Shinichi Watanabe",authors:[{id:"116893",title:"Dr.",name:"Shinichi",middleName:null,surname:"Watanabe",fullName:"Shinichi Watanabe",slug:"shinichi-watanabe"}]},{id:"47540",title:"Grasses (Poaceae) of Easter Island — Native and Introduced Species Diversity",slug:"grasses-poaceae-of-easter-island-native-and-introduced-species-diversity",signatures:"Víctor L. Finot, Clodomiro Marticorena, Alicia Marticorena,\nGloria Rojas and Juan A. Barrera",authors:[{id:"51657",title:"Dr.",name:"Victor",middleName:"Lionel",surname:"Finot",fullName:"Victor Finot",slug:"victor-finot"},{id:"59560",title:"Dr.",name:"Juan A.",middleName:null,surname:"Barrera",fullName:"Juan A. Barrera",slug:"juan-a.-barrera"},{id:"82311",title:"Prof.",name:"Clodomiro",middleName:null,surname:"Marticorena",fullName:"Clodomiro Marticorena",slug:"clodomiro-marticorena"},{id:"82313",title:"Prof.",name:"Gloria",middleName:null,surname:"Rojas",fullName:"Gloria Rojas",slug:"gloria-rojas"},{id:"171166",title:"Prof.",name:"Alicia",middleName:null,surname:"Marticorena",fullName:"Alicia Marticorena",slug:"alicia-marticorena"},{id:"173080",title:"Dr.",name:"Victor Lionel",middleName:null,surname:"Finot Saldías",fullName:"Victor Lionel Finot Saldías",slug:"victor-lionel-finot-saldias"}]},{id:"47573",title:"Plant Structure in the Brazilian Neotropical Savannah Species",slug:"plant-structure-in-the-brazilian-neotropical-savannah-species",signatures:"Suzane Margaret Fank-de-Carvalho, Nádia Sílvia Somavilla,\nMaria Salete Marchioretto and Sônia Nair Báo",authors:[{id:"144230",title:"Dr.",name:"Suzane",middleName:"Margaret",surname:"Fank-De-Carvalho",fullName:"Suzane Fank-De-Carvalho",slug:"suzane-fank-de-carvalho"},{id:"147894",title:"Dr.",name:"Maria Salete",middleName:null,surname:"Marchioretto",fullName:"Maria Salete Marchioretto",slug:"maria-salete-marchioretto"},{id:"171159",title:"Dr.",name:"Nádia Silvia",middleName:"Silvia",surname:"Somavilla",fullName:"Nádia Silvia Somavilla",slug:"nadia-silvia-somavilla"},{id:"171160",title:"Dr.",name:"Sônia",middleName:null,surname:"Bao",fullName:"Sônia Bao",slug:"sonia-bao"}]},{id:"47846",title:"Social Perception and Supply of Ecosystem Services — A Watershed Approach for Carbon Related Ecosystem Services",slug:"social-perception-and-supply-of-ecosystem-services-a-watershed-approach-for-carbon-related-ecosystem",signatures:"Antonio J. Castro, Caryn C. Vaughn, Jason P. Julian, Marina García\nLlorente and Kelsey N. Bowman",authors:[{id:"171155",title:"Dr.",name:"Antonio J",middleName:null,surname:"Castro",fullName:"Antonio J Castro",slug:"antonio-j-castro"},{id:"171356",title:"Dr.",name:"Caryn C.",middleName:null,surname:"Vaughn",fullName:"Caryn C. Vaughn",slug:"caryn-c.-vaughn"},{id:"171357",title:"Dr.",name:"Jason P.",middleName:null,surname:"Julian",fullName:"Jason P. Julian",slug:"jason-p.-julian"},{id:"171358",title:"BSc.",name:"Kelsey N.",middleName:null,surname:"Bowman",fullName:"Kelsey N. Bowman",slug:"kelsey-n.-bowman"},{id:"171359",title:"Dr.",name:"Marina",middleName:null,surname:"García-Llorente",fullName:"Marina García-Llorente",slug:"marina-garcia-llorente"}]},{id:"47644",title:"The Importance of Large Trees in Shrine Forests for the Conservation of Epiphytic Bryophytes in Urban Areas",slug:"the-importance-of-large-trees-in-shrine-forests-for-the-conservation-of-epiphytic-bryophytes-in-urba",signatures:"Yoshitaka Oishi and Keizo Tabata",authors:[{id:"142835",title:"Dr.",name:"Yoshitaka",middleName:null,surname:"Oishi",fullName:"Yoshitaka Oishi",slug:"yoshitaka-oishi"},{id:"173005",title:"Dr.",name:"Keizo",middleName:null,surname:"Tabata",fullName:"Keizo Tabata",slug:"keizo-tabata"}]},{id:"47908",title:"Miombo Woodlands Research Towards the Sustainable Use of Ecosystem Services in Southern Africa",slug:"miombo-woodlands-research-towards-the-sustainable-use-of-ecosystem-services-in-southern-africa",signatures:"Natasha Sofia Ribeiro, Stephen Syampungani, Nalukui M.\nMatakala, David Nangoma and Ana Isabel Ribeiro-Barros",authors:[{id:"171036",title:"Dr.",name:"Ana I.",middleName:null,surname:"Ribeiro-Barros",fullName:"Ana I. Ribeiro-Barros",slug:"ana-i.-ribeiro-barros"},{id:"173100",title:"Dr.",name:"Natasha Sofia",middleName:null,surname:"Ribeiro",fullName:"Natasha Sofia Ribeiro",slug:"natasha-sofia-ribeiro"},{id:"173101",title:"Dr.",name:"Stephan",middleName:null,surname:"Syampungani",fullName:"Stephan Syampungani",slug:"stephan-syampungani"},{id:"173102",title:"Dr.",name:"David",middleName:null,surname:"Nangoma",fullName:"David Nangoma",slug:"david-nangoma"},{id:"173170",title:"Mrs.",name:"Nalukui M.",middleName:null,surname:"Syampungani",fullName:"Nalukui M. Syampungani",slug:"nalukui-m.-syampungani"}]},{id:"47577",title:"Ecological Restoration in Conservation Units",slug:"ecological-restoration-in-conservation-units",signatures:"Suzane Bevilacqua Marcuzzo and Márcio Viera",authors:[{id:"105032",title:"Dr.",name:"Márcio",middleName:null,surname:"Viera",fullName:"Márcio Viera",slug:"marcio-viera"},{id:"171319",title:"Prof.",name:"Suzane Bevilacqua",middleName:null,surname:"Marcuzzo",fullName:"Suzane Bevilacqua Marcuzzo",slug:"suzane-bevilacqua-marcuzzo"}]},{id:"47699",title:"Actions for the Restoration of the Biodiversity of Forest Ecosystems in Cuba",slug:"actions-for-the-restoration-of-the-biodiversity-of-forest-ecosystems-in-cuba",signatures:"Eduardo González Izquierdo, Juan A. Blanco, Gretel Geada\nLópez, Rogelio Sotolongo Sospedra, Martín González González,\nBarbarita Mitjans Moreno, Alfredo Jimenez González and\nJosé Sánchez Fonseca",authors:[{id:"171377",title:"Dr.",name:"Eduardo",middleName:null,surname:"González Izquierdo",fullName:"Eduardo González Izquierdo",slug:"eduardo-gonzalez-izquierdo"},{id:"171432",title:"Dr.",name:"Gretel",middleName:null,surname:"Geada López",fullName:"Gretel Geada López",slug:"gretel-geada-lopez"},{id:"171433",title:"Dr.",name:"Rogelio",middleName:null,surname:"Sotolongo Sospedra",fullName:"Rogelio Sotolongo Sospedra",slug:"rogelio-sotolongo-sospedra"},{id:"171435",title:"Dr.",name:"Barbarita",middleName:null,surname:"Mitjans Moreno",fullName:"Barbarita Mitjans Moreno",slug:"barbarita-mitjans-moreno"},{id:"171507",title:"Dr.",name:"Martín",middleName:null,surname:"González González",fullName:"Martín González González",slug:"martin-gonzalez-gonzalez"},{id:"171508",title:"Prof.",name:"José",middleName:null,surname:"Sánchez Fonseca",fullName:"José Sánchez Fonseca",slug:"jose-sanchez-fonseca"},{id:"172926",title:"Dr.",name:"Alfredo",middleName:null,surname:"Jimenez González",fullName:"Alfredo Jimenez González",slug:"alfredo-jimenez-gonzalez"}]},{id:"47841",title:"Biodiversity in Metal-Contaminated Sites – Problem and Perspective – A Case Study",slug:"biodiversity-in-metal-contaminated-sites-problem-and-perspective-a-case-study",signatures:"E. Roccotiello, P. Marescotti, S. Di Piazza, G. Cecchi, M.G. Mariotti\nand M. Zotti",authors:[{id:"171311",title:"Dr.",name:"Enrica",middleName:null,surname:"Roccotiello",fullName:"Enrica Roccotiello",slug:"enrica-roccotiello"},{id:"171471",title:"Dr.",name:"Pietro",middleName:null,surname:"Marescotti",fullName:"Pietro Marescotti",slug:"pietro-marescotti"},{id:"171472",title:"Dr.",name:"Simone",middleName:null,surname:"Di Piazza",fullName:"Simone Di Piazza",slug:"simone-di-piazza"},{id:"171473",title:"Prof.",name:"Mauro",middleName:null,surname:"Mariotti",fullName:"Mauro Mariotti",slug:"mauro-mariotti"},{id:"171474",title:"Dr.",name:"Mirca",middleName:null,surname:"Zotti",fullName:"Mirca Zotti",slug:"mirca-zotti"},{id:"173004",title:"Dr.",name:"Grazia",middleName:null,surname:"Cecchi",fullName:"Grazia Cecchi",slug:"grazia-cecchi"}]},{id:"47524",title:"Underutilized Crops and Intercrops in Crop Rotation as Factors for Increasing Biodiversity on Fields",slug:"underutilized-crops-and-intercrops-in-crop-rotation-as-factors-for-increasing-biodiversity-on-fields",signatures:"Franc Bavec and Martina Bavec",authors:[{id:"170270",title:"Prof.",name:"Franc",middleName:null,surname:"Bavec",fullName:"Franc Bavec",slug:"franc-bavec"},{id:"171257",title:"Prof.",name:"Martina",middleName:null,surname:"Bavec",fullName:"Martina Bavec",slug:"martina-bavec"}]},{id:"47529",title:"Protected Areas and Ecosystem Services — Integrating Grassland Conservation with Human Well-Being in South Africa",slug:"protected-areas-and-ecosystem-services-integrating-grassland-conservation-with-human-well-being-in-s",signatures:"André Pelser, Nola Redelinghuys and Anna-Lee Kernan",authors:[{id:"50604",title:"Prof.",name:"Andre",middleName:"Johannes",surname:"Pelser",fullName:"Andre Pelser",slug:"andre-pelser"}]},{id:"47894",title:"Shortage of Biodiversity in Grassland",slug:"shortage-of-biodiversity-in-grassland",signatures:"Ricardo Loiola Edvan, Leilson Rocha Bezerra and\nCarlo Aldrovandi Torreão Marques",authors:[{id:"173155",title:"Dr.",name:"Leilson",middleName:"Rocha",surname:"Bezerra",fullName:"Leilson Bezerra",slug:"leilson-bezerra"},{id:"173156",title:"Prof.",name:"Carlo",middleName:null,surname:"Aldrovandi Torreão Marques",fullName:"Carlo Aldrovandi Torreão Marques",slug:"carlo-aldrovandi-torreao-marques"},{id:"283266",title:"Dr.",name:"Ricardo",middleName:null,surname:"Loiola Edvan",fullName:"Ricardo Loiola Edvan",slug:"ricardo-loiola-edvan"}]}]}],publishedBooks:[{type:"book",id:"9351",title:"Silvicultures",subtitle:"Management and Conservation",isOpenForSubmission:!1,hash:"f15a0f8b37429d28751d44f084e0ca69",slug:"silvicultures-management-and-conservation",bookSignature:"Fernando Allende Álvarez, Gillian Gomez-Mediavilla and Nieves López-Estébanez",coverURL:"https://cdn.intechopen.com/books/images_new/9351.jpg",editedByType:"Edited by",editors:[{id:"139581",title:"Dr.",name:"Fernando",surname:"Allende Álvarez",slug:"fernando-allende-alvarez",fullName:"Fernando Allende Álvarez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"4",chapterContentType:"chapter",authoredCaption:"Authored by"}},{type:"book",id:"9720",title:"Advances in Forest Management under Global Change",subtitle:null,isOpenForSubmission:!1,hash:"df888eab42f96e1bd89b300edfaec25a",slug:"advances-in-forest-management-under-global-change",bookSignature:"Ling Zhang",coverURL:"https://cdn.intechopen.com/books/images_new/9720.jpg",editedByType:"Edited by",editors:[{id:"219350",title:"Dr.",name:"Ling",surname:"Zhang",slug:"ling-zhang",fullName:"Ling Zhang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9727",title:"Silviculture",subtitle:null,isOpenForSubmission:!1,hash:"22ee60f177a2963821d834c66c466115",slug:"silviculture",bookSignature:"Ana Cristina Gonçalves",coverURL:"https://cdn.intechopen.com/books/images_new/9727.jpg",editedByType:"Edited by",editors:[{id:"194484",title:"Prof.",name:"Ana Cristina",surname:"Gonçalves",slug:"ana-cristina-goncalves",fullName:"Ana Cristina Gonçalves"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10248",title:"Ecosystem and Biodiversity of Amazonia",subtitle:null,isOpenForSubmission:!1,hash:"1218c819f575bd951d5de0e85f3ea006",slug:"ecosystem-and-biodiversity-of-amazonia",bookSignature:"Heimo Juhani Mikkola",coverURL:"https://cdn.intechopen.com/books/images_new/10248.jpg",editedByType:"Edited by",editors:[{id:"144330",title:"Dr.",name:"Heimo",surname:"Mikkola",slug:"heimo-mikkola",fullName:"Heimo Mikkola"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"616",title:"Forest Ecosystems",subtitle:"More than Just Trees",isOpenForSubmission:!1,hash:"00ecaa84de1aa2d7116ab5871b353b82",slug:"forest-ecosystems-more-than-just-trees",bookSignature:"Juan A. Blanco and Yueh-Hsin Lo",coverURL:"https://cdn.intechopen.com/books/images_new/616.jpg",editedByType:"Edited by",editors:[{id:"51995",title:"Dr.",name:"Juan",surname:"Blanco",slug:"juan-blanco",fullName:"Juan Blanco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"616",title:"Forest Ecosystems",subtitle:"More than Just Trees",isOpenForSubmission:!1,hash:"00ecaa84de1aa2d7116ab5871b353b82",slug:"forest-ecosystems-more-than-just-trees",bookSignature:"Juan A. Blanco and Yueh-Hsin Lo",coverURL:"https://cdn.intechopen.com/books/images_new/616.jpg",editedByType:"Edited by",editors:[{id:"51995",title:"Dr.",name:"Juan",surname:"Blanco",slug:"juan-blanco",fullName:"Juan Blanco"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"81569",title:"Impact of Interferon Alpha/Beta in the Management of Chronic Myeloproliferative Disorders",doi:"10.5772/intechopen.104501",slug:"impact-of-interferon-alpha-beta-in-the-management-of-chronic-myeloproliferative-disorders",body:'Chronic myeloproliferative disorders are a group of clonal diseases of the stem cell. It is a group of several diseases with some common features. They derive from a multipotential hematopoietic stem cell. A clone of neoplastic cells in all these neoplams is characterized by a lower proliferative activity than that of acute myeloproliferative diseases. In each of these diseases, leukocytosis, thrombocythemia, and polyglobulia may appear at some stage, depending on the diagnosis [1, 2].
The research on interferon has been going on since the 1950s [3]. Then, the attention was paid to its influence on the immune system. It has been noted that it can exert an antiproliferative effect by stimulating cells of the immune system [4]. In 1987, a publication by Ludwig et al. was published, which reported the effectiveness of interferon alpha in the treatment of chronic myeloproliferative disorders [5].
More and more new studies have been showing the effectiveness of interferon alpha in reducing the number of platelets, reducing the need for phlebotomies in patients with polycythemia vera and also in reducing the number of leukocytes. Moreover, interferon reduced the symptoms of myeloproliferative disorders such as redness and itching of the skin. Additionally, it turned out to be effective in reducing the size of the spleen.
Further studies on the assessment of remission using molecular-level response assessments indicate that the interferon action in chronic myeloproliferation diseases targets cells from the mutant clone with no effect on normal bone marrow cells [6].
Over the years, interferon alpha-2a and interferon alpha-2b have been introduced into the treatment of chronic myeloproliferation, followed by their pegylated forms. The introduction of pegylated forms allowed for a reduction in the number of side effects and less frequent administration of the drug to patients. In recent years, monopegylated interferon alpha-2b has been used to further increase the interval between drug administrations while maintaining its antiproliferative efficacy.
The exact mechanism of action of interferon alpha in the treatment of chronic myeloproliferative disease is still not fully understood, but it has an impact on JAK2 (Janus Kinase) signal transducers and activates the STAT signal pathway (Janus Kinase/SignalTransducer and Activator of Transcription).
Interferon alpha binds to IFNAR1 and IFNAR2c, which are type I interferon receptors. Interferon alpha has an impact on JAK2(Janus Kinase) signal transducers and activates the STAT signal pathway. The disturbances in this signaling pathway are observed in chronic myeloproliferative disorders [7].
Interferon inhibits the JAK-STAT signaling pathway by directly inhibiting the action of thrombopoietin in this pathway [8].
So far, three driver mutations have been described in the course of chronic myeloproliferative diseases that affect the functioning of the JAK-STAT pathway.
JAK2 kinase and JAK1, JAK3, and TYK2 kinases belong to the family of non-receptor tyrosine kinases. They are involved in the intracellular signal transduction of the JAK-STAT pathway. It is a system of intracellular proteins used by growth factors and cytokines to express genes that regulate cell activation, proliferation, and differentiation. The mechanism of JAK activation is based on the autophosphorylation of tyrosine residues that occurs after ligand binds to the receptor. JAK2 kinase transmits signals from the hematopoietic cytokine receptors of the myeloid lineage (erythropoietin, granulocyte-colony stimulating factor thrombopoietin, and lymphoid lineage [9].
A somatic G/T point mutation in exon 14 of the JAK2 kinase gene converts valine to phenylalanine at position 617 (V617F) in the JAK2 pseudokinase domain, which allows constitutive, ligand-independent activation of the receptor to trigger a proliferative signal [10].
Mutation of the MPL gene, which encodes the receptor for thrombopoietin, increases the sensitivity of magekaryocytes to the action of thrombopoietin, which stimulates their proliferation [11].
Malfunction of calreticulin as a result of mutation of the CARL gene leads to the activation of the MPL-JAK/STAT signaling pathway, which is independent of the ligand, as calreticulin is responsible, for the proper formation of the MPL receptor. Consequently, there is a clonal proliferation of hematopoietic stem cells [12].
Below, we provide an overview of some clinical studies on the efficacy of interferon in chronic myeloproliferative disorders.
Polycythemia vera (PV) is characterized by an increase in the number of erythrocytes in the peripheral blood.
Polycythemia vera is caused by a clonal mutation in the multipotential hematopoietic stem cell of the bone marrow. The mutation leads to an uncontrolled proliferation of the mutated cell clone, independent of erythropoietin and other regulatory factors. As the mutation takes place at an early stage of hematopoiesis, an increase of the number of erythrocytes as well as of leukocytes and platelets is observed in the peripheral blood. The cause of proliferation in PV independent from external factors is a mutation in the Janus 2 (JAK2) tyrosine kinase gene. The V617F point mutation in the JAK2 gene is responsible for about 96% mutation, and in the remaining cases the mutation arises in exon 12. Both mutations lead to constitutive activation of the JAK-STAT signaling pathway [13].
As a result of the uncontrolled proliferation, blood viscosity increases, which generates symptoms such as headaches and dizziness, visual disturbances, or erythromelalgia. As the number of all hematopoietic cells, including the granulocytes ones, increases, the difficult to control symptoms of their hyperdegranulation may appear, among which gastric ulcer or skin itching is often observed. During the disease progression, the spleen and liver become enlarged.
The most common complication of the disease is episodes of thrombosis, especially arterial one. During the course of the disease, it can also evolve into myelofibrosis or acute myeloid leukemia.
The treatment of PV is aimed at preventing thromboembolic complications, relieving the general symptoms, the appearance of hepatosplenomegaly as well as preventing its progression.
Each patient should receive an antiplatelet drug chronically, and usually acetylsalicylic acid is the choice. Most often, the treatment is started with phlebotomy in order to rapidly lower the hematocrit level. If cytoreductive therapy is necessary, the drugs of first choice are hydroxycarbamide and interferon [2].
However, the research on the mechanism of the action of interferons is still ongoing. In vitro studies with CD34+ cells from peripheral blood of patients diagnosed with polycythemia vera showed that interferon inhibits clonal changed cells selectively. It was found that interferon alpha-2b and pegylated interferon alpha-2a reduce the percentage of cells with JAK2 V617F mutation by about 40%. Pegylated interferon alpha-2a works by activating mitogen-activated protein kinase P38. It affects CD34+ cells of patients with polycythemia vera by increasing the rate of their apoptosis [6].
A case of a patient with PV with a confirmed chromosomal translocation t(6;8) treated with interferon alpha-2b, which resulted in a reduction of the clone with translocation by 50% from the baseline value, was also described [14].
In 2019, the results of a phase II multicenter study were published, which aimed at assessing the effectiveness of recombinant pegylated interferon alpha-2a in cases of refractory to previously hydroxycarbamide therapy. The study included 65 patients with essential thrombocythemia (ET) and 50 patients with polycythemia vera. All patients had previously been treated with hydroxycarbamide and showed resistance to this drug or its intolerance.
The assessment of the response was performed after 12 months of treatment. Overall response rate to interferon was higher in patients diagnosed with ET than in patients with polycythemia vera. In essential thrombocythemia, the percentage of achieved complete remissions was 43 and 26% of partial remissions. The remission rate in ET patients was higher if calreticulin CALR gene mutation was present. Patients with polycythemia vera achieved complete remission in 22% of cases and partial remission in 38% of cases.
Treatment-related side effects that follow to discontinuation of treatment were reported in almost 14% of patients [15].
The duration of response to treatment with pegylated interferon alpha-2a and the assessment of its safety in long-term use in patients with chronic myeloproliferative disorders was the goal of a phase II of the single-center study. Forty-three adult patients with polycythemia vera and 40 patients with essential thrombocythemia were enrolled in the study. The complete hematological response was defined as a decrease in hemoglobin concentration below 15.0 g/l, without phlebotomies, a resolution of splenomegaly, and no thrombotic episodes in the case of PV, and for essential thrombocythemia—a decrease platelet count below 440,000/μl and two other conditions as above. The assessment of the hematological response was performed every 3–6 months. The median follow-up was 83 months.
The hematological response was obtained in 80% of cases for the entire group. In patients with polycythemia vera, 77% of patients achieved a complete response (CR) while 7% a partial response (PR). The duration of response averaged 65 months for CR and 35 months for PR. In the group of patients diagnosed with essential thrombocythemia, CR was achieved in 73% and PR in 3%. The durance of CR was 58 months and PR was 25 months.
The molecular response for the entire group was achieved in 63% of cases.
The overall analysis showed that the duration of hematological remission and its achievement with pegylated interferon alpha-2a treatment is not affected neither by baseline disease characteristics nor JAK2 allele burden and disease molecular status. There was also no effect on age, sex, or the presence of splenomegaly.
During the course of the study, 22% of patients discontinued the treatment, because of toxicity. Toxicity was the greatest at the beginning of treatment. The starting dose was 450 μg per week and was gradually tapered off.
Thus, on the basis of the above observations, the researchers established that pegylated interferon alpha-2a may give long-term hematological and molecular remissions [16].
The assessment of pegylated interferon alpha-2a in group of patients diagnosed with polycythemia vera only was performed. The evaluation was carried out on a group of 27 patients. Interferon decreased the JAK2 V617F allele burden in 89% of cases. In three patients who were JAK2 homozygous at baseline, after the interferon alpha-2a treatment wild-type of JAK2 reappeared. The reduction of the JAK2 allele burden was estimated from 49% to an average 27%, and additional in one patient the mutant JAK2 allele was not detectable after treatment. It can therefore be postulated that the action of pegylated interferon alpha-2a is directed to cells of the polycythemia vera clone [17].
In 2005, the results of treatment by pegylated interferon alpha-2b of 21 patients diagnosed with polycythemia vera and 21 patients diagnosed with essential thrombocythemia were published. In the case of polycythemia vera in 14 patients, PRV-1 gene mutation was initially detected. In 36% of cases, PRV-1 expression normalized after treatment with pegylated interferon alpha-2b. For the entire group of 42 patients, the remission assessment showed that complete remission was achieved in 69% cases after 6 months of treatment. However, only in 19 patients remission was still maintained 2 years after the start of the study. Pegylated interferon alpha-2b was equally effective in patients with PV and ET. The use and the type of prior therapy did not affect the achievement of remission [18].
Another study with enrolled only PV patients included 136 patients. They were divided into two arms. One group received interferon alpha-2b and the other group received hydroxycarbamide. Interferon dosage was administered in 3 million units three times a week for 2 years and then 5 million units two times a week. Hydroxycarbamide was administered at a dose between 15 and 20 mg/kg/day.
In the group of patients treated with interferon, a significantly lower percentage of patients developed erythromelalgia (9.4%) and distal parasthesia (14%) compared with the group treated with hydroxycarbamide, for whom these percentages were respectively: 29 and 37.5%. Interferon alpha-2b was found to be more effective in inducing a molecular response, which was achieved in 54.7% of cases, in comparison with hydroxycarbamide—19.4% of cases, despite the fact that the percentage of achieved general hematological responses did not differ between the groups and amounted about 70%. The 5-year progression free period in the interferon group was achieved in a higher percentage (66%) than in the hydroxycarbamide group (46.7%) [19].
The most recent form of interferon approved by the
Thanks to these changes to the structure of the molecule, it was possible to achieve a significant increase in its half-life. Ropeginterferon can be administered subcutaneously to patients every 14 days. The clinical trials conducted so far have assessed the ropeginterferon dose from 50 micrograms to a maximum dose of 500 microgams administered as standard every 2 weeks. The possible dose change in case of side effects includes not only the reduction of the drug dose itself, but also the extension of the interval between doses. The extension of the dosing interval up to 4 weeks was assessed.
Ropeginterforn was approved in 2019 by the EMA for the use in patients diagnosed with polycythemia vera without splenomegaly, as monotherapy.
Ropeginterferon, like the previous forms of interferons used in treatment, is contraindicated in patients with severe mental disorders, such as severe depression. It is also a contraindication in patients with noncompensatory standard treatment of disorders of the thyroid gland as well as severe forms of autoimmune diseases. The safety profile of ropeginterferon is similar to that of other forms of alpha interferons. The most common side effects are flu-like symptoms [20].
Ropeginterferon has been shown to exhibit in vitro activity against JAK2-mutant cells. The activity of ropeginterferon against JAK2-positive cells is similar to that of other forms of interferons used actually for standard therapy. Ropeginterferon has an inhibitory effect on erythroid progenitor cells with a mutant JAK2 gene. At the same time, it has almost no effect on progenitor cells without the mutated allele (JAK2-wile-type) and normal CD34+ cells. A gradual decrease of JAK2-positive cells was observed in patients with PV during ropeginterferon treatment. The examination was performed after 6 and 12 months of treatment. In comparison, the reduction in the percentage of JAK2 positive cells in patients treated with hydroxycarbamide was significantly lower.
These results may suggest that ropeginterferon may cause elimination of the mutant clone, but further prospective clinical trials are needed to confirm this theory. The evaluation was performed on a group of patients enrolled in the PROUD-PV study who were treated in France [21].
In 2017, a multicenter study was opened in Italy. The study was of the second phase. In total, 127 patients with polycythemia vera were included in the study. All patients enrolled on the study had low-risk PV. The clinical trial consisted of two arms. Patients received phlebotomies and low-dose aspirin in one arm and ropeginterferon in the other arm. The aim of the study was to achieve a hematocrit of 45% or lower without any evidence of disease progression. Ropeginterferon was administered every 2 weeks at a constant dose of 100 μg.
The response to the treatment was assessed after 12 months. The reduction of hematocrit to the assumed level was achieved in significantly higher percentage of patients in the ropeginterferon group than of patients who received only phlebotomies and aspirin. In addition, none of the patients treated with ropeginterferon experienced disease progression during the course of the study, while among those treated with phlebotomies, 8% of patients progressed.
Grade 4 or 5 adverse events were not observed in patients treated with ropeginterferon, and the incidence of remaining adverse event (AE) was small and comparable in both arms. The most common side effects in the ropeginterferon group were flu-like symptoms and neutropenia; however, the third-grade neutropenia was the most common (8% of cases) [22].
One of the most important clinical studies on the use of ropeginterferon was the PROUD-PV study and its continuation: the CONTINUATION-PV study. These were three-phase, multicenter studies. The aim of the study was to compare the effectiveness of ropeginterferon in relation to hydroxycarbamide. The study included adult patients diagnosed with polycythemia vera treated with hydroxycarbamide for less than 3 years and no cytoreductive treatment at all. In total, 257 patients received this treatment. The patients were divided into two groups: those receiving ropeginterferon or the other being given hydroxycarbamide.
During the PROUD-study, drug doses were increased until the hematocrit was achieved below 45% without the use of phlebotomies, and the normalization of the number of leukocytes and platelets was reached.
The PROUD-PV study lasted 12 months. After this time, the patients continued the treatment under the CONTINUATION-PV study for further 36 months. After the final analysis performed in the 12th month at the end of PROUD study, it was found that the hematological response rates did not differ between the ropeginterferon and hydroxycarbamide treatment groups. These were consecutively 43% in the ropeginterferon arm and 46% in the control arm.
However, after analyzing the CONTINUATION- PV study, it turned out that after 36 months of treatment, the rates of hematological responses begin to prevail in the group of patients receiving ropeginterferon, 53% versus 38% in the control group. Thus, from the above data, it can be seen that the response rate to ropeginterferon increases with the duration of treatment [23].
Another analysis of patients participating in the PROUD and CONTINUATION studies was based on the assessment of treatment results after 24 months, dividing patients into two groups according to age (under and over 60 years).
The initial comparison of both groups of patients showed that older patients had a more aggressive course of the disease. Patients over 60 years of age had a higher percentage of cells with a mutant JAK2 allele. They experienced both general symptoms and some complications, such as thrombosis, more frequently. Both patients under 60 years of age and over 60 years of age in the ropeginterferon arm had a higher rate of molecular response, namely 77.1 and 58.7% compared with the HU remission: 33.3 and 36.1%, respectively. Significantly higher reductions in the JAK2 allele were observed in both groups of patients after ropeginterferon treatment: it was 54.8% for younger patients and 35.1% for elderly patients. For comparison, this difference in the group of patients treated with HU was 4.5 and 18.4%, respectively.
What is more, the age did not affect the frequency of ropeginterferon side effects. In addition, the incidence of adverse ropeginterferon disorders was similar to that observed in the hydroxycarbamide group [24].
Essential thrombocythemia is a clonal growth of multipotential stem cells in the bone marrow. The consequence of this is increased proliferation of megakaryocytes in the bone marrow and an increase in the number of platelets in the peripheral blood. The level of platelets above 450,000/μl is considered a diagnostic criterion.
Essential thrombocythemia may progress over time to a more aggressive form of myeloproliferation, i.e., myelofibrosis. The disease can also evolve into acute myeloid leukemia or myelodysplastic syndrome, both with very poor prognosis. Thromboembolic complications are serious, and they concern over 20% of patients. Thrombosis occurs in the artery and venous area. Moreover, in patients with a very high platelet count, above 1,000,000/μl, bleeding may occur as a result of secondary von Willebrand syndrome [1, 2].
The treatment of ET is primarily aimed to prevent thrombotic complications.
In low-risk patients, only acetylsalicylic acid is used. In cases of high-risk patients, hydroxycarbamide is the first-line drug for most patients. Anagrelide and interferon are commonly used as second-line drugs.
Due to the possible effects of hydroxycarbamide of cytogenetic changes in the bone marrow cells after long-lasting usage, some experts recommend the use of interferon in younger patients in the first line. Interferon is also used as the drug of choice in patients planning a pregnancy [25].
The efficacy of pegylated interferon alpha-2a was assessed on the basis of the group of 39 patients with essential thrombocythemia and 40 patients with polycythemia vera.
Of the overall group, 81% of patients were previously treated prior to the study entry. The patients received pegylated interferon alpha-2a in a dose of 90 μg once a week. The dose of 450 μg was associated with a high percentage of intolerance.
In patients with essential thrombocythemia, the complete remission was achieved in 76%, while the overall hematological response rate brought 81%. Moreover, the molecular remission was achieved in 38%, in 14% of cases, JAK2 transcript became not detectable.
Patients diagnosed with polycythemia vera achieved 70% complete hematological remission and 80% general hematological response to treatment. JAK2 transcript was undetectable in 6% of patients. Molecular remission was achieved in 54% of cases.
Pegylated interferon alpha-2a at the dose of 90 μg per week was very well tolerated. In total, 20% of patients experienced a grade of 3 or 4 of adverse reaction, which was neutropenia. In addition, an increase in liver function tests was observed. Grade 4 of AE was not observed among patients who started the treatment with 90 μg/week while grade 3 neutropenia was an adverse event in only 7% of cases [26].
The effect of interferon alpha-2b treatment in patients with ET and PV was investigated. The study was prospective. Some of the results concerning the group of patients with polycythemia vera are presented in the subsection on polycythemia vera. In total, 123 patients with diagnosed essential thrombocythemia participated in the study. All of them received interferon alpha-2b. The patients were divided into two groups depending on the presence of the JAK2 V617F mutation. The enrolled patients were between 18 and 65 years of age. The treatment they received was, sequentially, interferon alpha-2b in the dose of 3 million units three times a week for the first 2 years, after which time the dose was changed into a maintenance dose, which amounted to 5 million units two times a week.
The analysis showed that the patients with the JAK2 V617F mutation present in a higher percentage achieved an overall hematological response as well as a complete hematological response. The overall hematological response was achieved in 83% of patients with JAK2 mutation, and the complete hematological remission was achieved in 23 cases. In the group of ET patients without the JAK2 V617F mutation, overall hematological response was achieved in 61.4%, while the complete hematological remission was achieved in 12 patients. The 5-year progression-free survival was obtained in 75.9% in the JAKV617F group and only in 47.6% without the mutation.
A significant proportion of patients experienced mild side effects. Grade 3 and 4 of adverse events were severe, most of them being a fever. The isolated cases of elevated liver tests and nausea have also been reported [19].
Pegylated interferon alpha-2b in patients with essential thrombocythemia who were previously treated with hydroxycarbamide, anagrelide, and other forms of interferon alpha, however, due to the lack of efficacy or toxicity, the patients required a change of treatment, was assessed. Pegylated interferon alpha-2b turned out to be effective in these cases. It led to the complete hematological remission in 91% of patients after 2 months of therapy, and in 100% of patients after 4 months. However, merely 11 patients participated in the study. Also only two patients required treatment discontinuation due to the side effects such as depression and general fatigue grade 3 [27].
In case of pregnant patients, interferon is currently considered the only safe cytoreductive drug. Over the years, several analyses of the results of interferon treatment during pregnancy have been carried out.
The assessment of 34 pregnancies in 23 women diagnosed with ET was performed retrospectively. All the pregnancies included in the analysis were of high risk. This high risk was associated with a high platelet count above 1,500,000/μl, a history of thrombotic episode, severe microcirculation disorders, or a history of major hemorrhage.
It turned out that the use of interferon allowed the birth of an alive child in 73.5% of cases. There was no difference in efficacy between the basic and pegylated forms of interferon alpha. In pregnancies without interferon treatment, the percentage of live births was only 60%. Moreover, it was not found if the presence of the JAK2 V617F mutation had any influence on the course of pregnancy [28].
An analysis of the course of pregnancy in patients with ET was assessed in Italy. Data from 17 centers were taken into account. Data from 122 pregnancies were collected from 92 women. In patients diagnosed with essential thrombocythemia, the risk of the spontaneous loss of pregnancy is about 2.5 times higher than among the general population. In the contrary to the study quoted above, it was found that the presence of the JAK2 mutation increases the risk of pregnancy loss. The proportion of live births in patients exposed to interferon during pregnancy was 95%, compared with 71.6% in the group of patients not treated with interferon.
The multivariate analysis also showed that the use of acetylsalicylic acid during pregnancy had no effect on the live birth rate of patients with ET [29].
Whatever its form, interferon is the drug of first choice in pregnancy. Hydroxycarbamide and anagrelide should be withdrawn for about 6 months, and at least for 3 months, before the planned conception. Experts recommend the use of interferon in high-risk pregnancies [30]. A Japanese analysis of 10 consecutive pregnancies in ET patients showed 100% live births in patients who received interferon [31].
In myelofibrosis (MF), monoclonal megakaryocytes produce cytokines that stimulate the proliferation of normal, non-neoplastic fibroblasts and stimulate angiogenesis. The consequence of this is the gradual fibrosis of the bone marrow, impaired hematopoiesis in the bone marrow, and the formation of extramedullary location mainly in the sites of fetal hematopoiesis, i.e., in the spleen and the liver.
The production of various cytokines by neoplastic megakaryocytes leads to the proliferation of normal, noncancerous fibroblasts as well as to increased angiogenesis.
Progressive bone marrow fibrosis leads to worsening anemia and thrombocytopenia. On the other hand, the production of proinflammatory cytokines by megakaryoblasts leads to the general symptoms such as weight loss, fever, joint pain, night sweats, and consequently, progressive worsening of general condition.
The prognosis for myelofibrosis is poor. In about 20% of patients, myelofibrosis evolves into acute myeloid leukemia with poor prognosis.
Currently, the only effective method of treatment that gives a chance to prolong the life is allogeneic bone marrow transplantation. However, this method is only available to younger patients.
The goal of treatment of patients who have not been qualified for allotranspalntation is to reduce the symptoms and to improve the patient’s quality of life. In case of leukocytosis cytoreducing drugs, such as hydroxycarbamide, melphalan, or cladribine can be used. They cause a reduction in the number of leukocytes and may, to some extent, inhibit splenomegaly. Interferon alpha has been used successfully for the treatment of myelofibrosis for many years. The results of its effectiveness will be presented below [2].
Currently, the JAK2 inhibitor ruxolitinib is approved for the treatment of myelofibrosis with enlarged spleen in intermediate and high-risk patients. Ruxolitinib reduces the size of the spleen, reduces general symptoms, and improves the quality of life; however, it does not prolong the overall survival of patients [32].
In 2015, the results of a retrospective study were published to compare the histological parameters of the bone marrow before and after interferon treatment. Twelve patients diagnosed with primary myelofibrosis as well as post-PV MF and post-ET MF were enrolled in the study. Patients were treated with pegylated recombinant interferon alpha-2a or recombinant interferon alpha-2b in standard doses. The time of treatment was from 1 to 10 years. Some patients had previously been treated with hydroxycarbamide or anagrelide. In all cases, karyotype was normal. The prognostic factor of Dynamic International Prognostic Scoring System (DIPSS) was assessed at the beginning as well as during the treatment.
Bone marrow cellularity decreased in cases with increased bone marrow cellularity before the treatment. After the interferon treatment, a reduction in the degree of bone marrow fibrosis was found. The parameters, such as the density of naked nuclei and the density of megakaryocytes in the bone marrow, also improved.
It proves that if the JAK2 V617F mutation had been present, DIPSS was decreased after interferon treatment. This relationship was not observed in patients without the JAK2 V617F mutation. The improvement in peripheral blood morphological parameters and the overall clinical improvement correlated with the improvement in the assessed histological parameters of the bone marrow.
Before the initiation of interferon, seven patients had splenomegaly. During the treatment with interferon, the complete resolution of splenomegaly was achieved in 17% of patients (two cases), and its size decreased in 25% (three cases). A good clinical response was achieved in 83% during interferon therapy. There was no significant difference in response between the two types of interferon used [33].
A prospective study was also conducted in patients with low and intermediate-1 risk group myelofibrosis. Seventeen patients were enrolled. Patients received interferon alpha-2b (0.5–3 milion units/three times a week) or pegylated interferon alpha-2a (45–90 μg/week). The duration of therapy was on average 3.3 years.
Most of the patients responded to the treatment. Partial remission was found in seven patients and complete remission in two patients. Moreover, in four cases, the disease was stabilized and in one case the clinical improvement was achieved. Three patients did not respond to treatment at all and progressed to myelofibrosis. Additionally, the assessment in reducing spleen size was performed. At baseline, 15 patients have splenomegaly, nine of them achieved the compete regression of spleen size [34].
However, the efficacy of interferon in the treatment of myelofibrosis appears to be limited only to a less advanced form, when the bone marrow still has an adequate percentage of normal hemopoiesis and the marrow stroma is not significantly fibrotic. In more advanced stages, interferon was not shown to have any significant effect on the regression of the fibrosis process [35].
In 2020, the results of the COMBI study were published. That was a two-phase, multicenter, single-arm study that investigated the efficacy and safety of the combination of ruxolitinib and pegylated interferon alpha. Thirty-two patients with PV and 18 patients with primary and secondary myelofibrosis participated in the study. The patients were at age 18 and older. Remission was achieved in 44% of myelofibrosis cases, including 28% (5 patients) of complete remission. In patients with PV, the results were slightly worse: 31% of remissions, including 9% of complete remissions. Patients received pegylated interferon alpha-2a (45 μg/week) or pegylated interferon alpha-2b (35 μg/week) in low doses and ruxolitinib in doses of 5–20 mg twice a day.
For the entire group of patients (with PV and MF), the initial JAK2 allele burden was 47% at baseline, and after 2 years of treatment with interferon and ruxolitinib, it decreased to 12%.
The treatment toxicity was low. The highest incidence of side effects occurred at initiation of therapy. It was mostly anemia and thrombocytopenia.
The observations from the COMBI study show that, for the combination of interferon in lower doses with ruxolitinib, it may be effective and well tolerated even in the group of patients who had intolerance to interferon used as the only drug in higher doses. The combined treatment improved the bone marrow in terms of fibrosis and its cellularity. It also allowed to improve the value of peripheral blood counts [36].
It is currently known that some of the additional mutations are associated with a worse prognosis in patients with myelorpoliferation, including patients with myelofibrosis. Some of these mutations have been identified as high-risk molecular mutations. These are ASXL1, EZH2, IDH1/2, or SRSF2. Earlier studies have shown their association with a more aggressive course of the disease, worse prognosis, and shorter survival of patients, as well as a poorer response to treatment. Due to their importance, they have been included in the diagnostic criteria of myelofibrosis [37].
It is also known that the presence of driver mutations, i.e., JAK2, CALR, and MPL or triple negativity, may affect the course of myeloproliferation, including the incidence of thromboembolic complications.
The assessment of the influence of driver mutations and a panel of selected additional mutations on the effectiveness of interferon treatment in patients with myelofibrosis was performed on a group of 30 patients. Only the patients with low- and intermediate-1-risk were enrolled in the study. The treatment with pegylated interferon alpha-2a or interferon alpha-2b resulted in a complete remission in two patients and partial remission in nine patients. The disease progressed in three cases. One patient relapsed and four died. The remaining patients achieved a clinical improvement or disease stabilization. In the studied group, it was not found if the effectiveness of interferon treatment was influenced by the lack of driver mutations. Among the group of four patients with additional mutations, two died and one had disease progression. It was a mutation of ASXL1 and SRSF2. The treatment with interferon in patients without additional molecular mutations in the early stages of the disease may prevent further progression of the disease [38].
The side effects of interferon in the group of patients with myelofibrosis are similar to those occurring after the treatment of other chronic myeloproliferative diseases. The most frequently described are hematological toxicity- anemia and thrombocytopenia, less often is the appearance of leukopenia. Hematological toxicity usually resolves with dose reduction or extension of the dose interval. The most frequently nonhematological toxicity was fatigue, muscle pain, weakness, and depression symptoms. All symptoms are usually mild and do not exceed grade 2 [38].
However, the use of interferon in the treatment of myelofibrosis has not been recommended as a standard therapy. Interferon is still being evaluated in clinical trials, or it is used in selected patients as a nonstandard therapy in this diagnosis.
Mastocytosis is characterized by an excessive proliferation of abnormal mast cells and their accumulation in various organs.
The basis for the development of mastocytosis is ligand-independent activation of the KIT receptor, resulting from mutations in the KIT proto-oncogene. The KIT receptor is a trans membrane receptor with tyrosine kinase’s activity. Its activation stimulates the proliferation of mast cells. That excessive numbers of mast cells infiltrate tissues and organs and release mediators such as histamine, interleukine-6, tryptase, heparin, and others, which are responsible for the appearance of symptoms typical of mastocytosis. In addition, the infiltration of tissues for mast cells itself causes damage to the affected organs.
The prognosis of mastocytosis depends on the type of the disease. In the case of cutaneous mastocytosis (CM), in the majority of cases prognosis is good and the disease does not shorten the patient’s life, but in aggressive systemic mastocytosis (ASM), the average follow-up is about 40 months. Mast cell leukemia has a poor prognosis with a median follow-up of approximately 1 year.
Systemic mastocytosis usually requires the implementation of cytoreductive therapy. The first line of therapy is interferon alone or its combination with corticosteroids. In aggressive systemic mastocytosis, the first line in addition to interferon 2-CdA can be used. An effective drug turned out to be midostaurin in the case of the present KIT mutation. In patients without the KIT D816V mutation, treatment with imatinib may be effective. In the case of mast cell leukemia, multidrug chemotherapy is most often required, as in acute leukemias, followed by bone marrow transplantation [39].
Systemic mastocytosis requiring treatment is a rare disease, this is why the studies available in the literature evaluating various therapies concern mostly small groups of patients.
In 2002, the French authors presented their experiences on the use of interferon in patients with systemic mastocytosis. They included 20 patients. The patients received interferon alpha-2b in gradually increased doses.
The patients were assessed after 6 months. In cases in which bone marrow was infiltrated for mast cells at baseline, it still remained infiltrated after 6 months of treatment.
However, the responses were obtained in terms of symptoms related to mast cell degranulation. Partial remission was achieved in 35% of patients and minor remission in 30%. It concerns mainly skin lesions and vascular congestion. Moreover, the assessment of the histamine level in the plasma revealed a decrease of it in patients who previously presented symptoms related to the degranulation of mast cells, such as gastrointestinal disorders and flushing.
A high percentage of side effects were found during treatment. They concerned 35% of patients. Depression and cytopenia were most frequent ones [40].
Another analysis was a report of five patients with systemic mastocytosis treated with interferon and prednisolone. All patients received interferon alpha-2b in a dose of 3 million units three times a week and four patients additionally received prednisolone. Four patients responded to interferon treatment at varying degrees. One patient, who at baseline had bone marrow involvement by mast cells in above 10%, progressed to mast cell leukemia. In two patients, the symptoms C resolved completely and in one of them they partially disappeared. In one case, stabilizing disease was achieved [41].
In 2009, a retrospective analysis of patients treated with cytoreductive therapy due to mastocytosis was published. The authors collected data from 108 patients treated at the Mayo Clinic. This analysis allowed for the comparison of the efficacy of four drugs used in systemic mastocytosis. There were interferon alpha alone or in the combination with prednisone—among 40 patients, hydroxycarbamide—among 26 ones, imatinib—among 22 persons, and 2-chlorodeoxyadenosine (2-CdA)—among 22 patients.
After dividing the patients into three additional groups on the basis of the type of mastocytosis—indolent systemic mastocytosis, aggressive systemic mastocytosis, and systemic mastocytosis associated with another clonal hematological nonmast cell lineage disease (SM-AHNMD)—the effectiveness of each of type of therapy was assessed.
The highest response rates in indolent and aggressive mastocytosis were achieved with interferon treatment. They were 60% of the responses in both groups, and in the SM-AHNMD group of patients, the percentage was also one of the highest and amounted to 45%. The second most effective drug was 2-CdA. The response rates were 56% for indolent MS, 50% for aggressive MS, and 55% for SM-AHNMD. The patients treated with imatinib achieved response in 14, 50, and 9% by following groups, respectively. In contrast, patients with indolent and aggressive systemic mastocytosis did not respond to hydroxycarbamide treatment at all. The response rate in both groups was 0%. However, patients with MS associated with another clonal hematological nonmast cell lineage disease achieved 21% response to hydroxycarbamide. Additionally, it was found that only interferon relieved symptoms caused by the release of inflammatory mediators by mast cells.
The additional analysis showed no influence of the TET 2 mutation on the response to treatment [42].
In the literature, there are also single cases of mastocytosis presenting trials of nonstandard treatment. That is description of a patient with systemic mastocytosis with mast cell bone marrow involvement. Mutation of c-kit Asp816Val was present. Patient progressed despite treatment with dasatinib and 2-chlorodeoxyadenosine. The patient developed symptoms related to the degranulation of mast cells and increased ascites.
The patient was treated with pranlukast, which is an anti-leukotriene receptor antagonist due to an asthma episode. The rate of ascites growth decreased significantly after one administration. The patient required paracentesis every 10 days and not every 3 days, as before starting to take the drug. After 15 days of treatment with pranlukast, the patient received interferon alpha, which resulted in complete regression of ascites, resolution of pancytopenia, and complete disappearance of the c-kit mutation clone. The infiltration of mast cells in the bone marrow significantly decreased [43].
Interferon alpha was also effective in a patient with systemic mastocytosis associated with myelodysplastic syndrome with the c-kit D816V mutation, which was refractory to imatinib treatment [44].
Interferon alpha also proved to be effective in the treatment of osteoporotic lesions appearing in the course of mastocytosis.
The series of 10 cases with resolved mastocytosis and osteoporosis-related fractures was presented in 2011. The patients received interferon alpha in a dose of 1.5 million units three times a week as well as pamindronic acid. The patients were treated for an average of 60 months. For the first 2 years, pamindronate was given at a dose of 1 mg/kg every month, and then every 3 months.
During the course of the study, no patient had a new-bone fracture. The level of alkaline phosphatase decreased by 25% in relation to the value before treatment and tryptase by 34%. Bone density increased during treated with interferon and pamindronate. The increase was on average 12% in the spine bones and 1.9% in the hip bones. At the same time, there was no increase in the density of the hip bone and a minimal increase in the density of the spine in patients treated with pamindronate alone.
The results of this observation suggest that it is beneficial to add low doses of interferon alpha to pamindronate treatment in terms of bone density increase [45].
That experiences show that interferon used in systemic mastocytosis significantly improves the quality of life of patients by inhibiting the symptoms caused by degranulation of mast cells. They prevent bone fractures and, in some patients, they cause remission of bone marrow infiltration by mast cells.
Chronic neutrophilic leukemia (CNL) is a very rare disease. It is characterized by the clonal proliferation of mature neutrophils.
The diagnostic criteria proposed by the World Health Organization (WHO) comprise leukocyte counts above 25,000/μl (including more than 80% of rod and segmented
Physical examination often shows enlargement of the liver and spleen, moreover, patients complain on weight loss and weakness [1].
The prognosis varies. The average survival time for patients with CNL is less than 2 years.
Only few descriptions of chronic neutrophilic leukemia are available in the literature, and these are mostly single case reports.
Because it is an extremely rare disease, there are no established and generally accepted treatment standards. In most cases, patients are given hydroxycarbamide or interferon. Patients who are eligible for a bone marrow transplant may benefit from this treatment. Bone marrow allotransplantation remains the only method that gives a chance for a significant extension of life.
The German authors presented a series of 14 cases of chronic neutrophilic leukemia. The group of patients consisted of eight women and six men. The average age was 64.7 years. From the entire group of patients, longer survival was achieved only in three cases. One of these patients was treated with interferon alpha and achieved hematological remission, the other underwent bone marrow allotransplantation from a family donor, and the third one was treated with hydroxycarbamide and transfusions as needed. The follow-up period of the patient after allogeneic matched related donor transplantation (allo-MRD) was 73 months, and for the patient after interferon treatment it was 41 months.
The remaining patients died within 2 years of diagnosis. Six patients, the largest group, died due to intracranial bleeding, three patients died because of leukemia cell tissue infiltration, one patient because of the disease transformation into leukemia, and one patient because of pneumonia [46].
It can be seen from these experiences that treatment with interferon alpha can significantly extend the survival time of patients.
The case of a 40-year-old woman diagnosed with chronic neutrophilic leukemia is presented by Yassin and coauthors. Initially, the patient had almost 41,000 leukocytes in the peripheral blood. In a physical examination, splenomegaly and hepatomegaly were not present. Patient received pegylated interferon alpha-2a. The initially dose was 50 μg once a week for the first 2 weeks, then the dose was increased to 135 μg weekly for 6 weeks, and then the dose interval was extended to another 2 weeks. As a result of the treatment, the general condition of the patient improved and the parameters of peripheral blood counts were normalized [47].
Another case report presented in the literature describes a 41-year-old woman diagnosed with CNL accompanied by focal segmental glomerulosclerosis (FSGS). The patient had increasing leukocytosis for several months. On the admission to the hospital, leukocytosis was 94,000/μl. Moreover, the number of platelets in the morphology exceeded 1,000,000/μl. More than a year earlier, the patient had splenectomy due to splenomegaly and spleen infraction.
Additionally, JAK2 V617F mutation was found. Some authors suggest that the presence of JAK2 mutation may be associated with longer survival in CNL.
The patient received hydroxycarbamide for 3 months and reduction in the number of leukocytes was achieved. After this time, interferon alpha-2b was added to hydroxycarbamide. As a result, focal segmental glomerulosclerosis disappeared and the renal tests improved [48].
Another case of chronic neutrophilic leukemia with a JAK2 gene mutation concerns a 53-year-old man. The patient’s baseline leukocytosis was 33,500/μl, including the neutrophil count of 29,700/μl. The patient also had splenomegaly.
The treatment with interferon alpha-2b at a dose of 3 million units every other day was started. After a month of treatment, the number of leukocytes was reduced to less than 10,000/μl. Then the patient was treated chronically with interferon alpha-2b in doses of 3 million units every 2 weeks. As a result of the therapy, the number of leukocytes remains between 8 and 10,000/μl. The patient remains in general good condition [49].
A series of two CNL cases are also shown. The first patient was a 70-year-old woman with stable leukocytosis of about 35,000/μl and the remaining morphology parameters in normal range. The patient was only observed for 5 years until hepasplenomegaly progressed rapidly. Then, interferon alpha-2b was included. Due to the treatment, the rapid regression of hepatosplenomegaly was achieved.
The second case is a 68-year-old woman with baseline leukocytosis of almost 14,000/μl. In this case, the treatment with hydroxycarbamide was started immediately. However, no improvement was achieved. After 6 weeks of HU treatment, interferon alpha-2b 3 million units 3 times a week was implemented and leukocytosis decreased. Due to the interferon treatment, the disease stabilized for a long time. Because the patient experienced an adverse reaction, a severe flu-like syndrome, interferon was discontinued. After interferon withdrawal, the disease progressed gradually and the treatment attempts by busulfan and 6-mercaptopurine were unsuccessful. Therefore, interferon was readministered and the disease went into remission. Interferon treatment was continued at a reduced dose. The disease regression was achieved again.
Additionally, the patient showed an improvement in the function of granulocytes in terms of phagocytosis and an improvement in neutral killer (NK) cell function after treatment with interferon [50].
The above examples show that interferon alpha is effective in the treatment of chronic neutrophilic leukemia. The side effects are rare and can be managed with dose reductions. Moreover, in these cases, interferon is also effective in a reduced dose. Disease remission or regression can be achieved without typical of CNL complications, such as intracranial bleeding.
Interferon has been used in the past to treat chronic myeloid leukemia. The treatment with tyrosine kinase inhibitors is now a standard practice. However, in a small number of patients, they are ineffective or exhibit unmanageable toxicity. Therefore, the attempts are underway to use interferon in combination with TKI in lower doses, which is to ensure the enhancement of the antiproliferative effect while reducing the toxicity.
There are ongoing attempts to use ropeginterferon in patients diagnosed with chronic myeloid leukemia, in whom treatment with imatinib alone has not led to deep molecular response (DMR). The first phase study was conducted in a small group of patients with chronic myeloid leukemia. The patients in first chronic phase treated with imatinib who did not achieve DMR, but in complete hematologic remission and complete cytogenetic remission, were included in the study. Patients have been treated with imatinib for at least 18 months. Twelve patients were enrolled in the study, and they completed the study according to the protocol. These patients received additional ropeginterferon to imatinib and four achieved DMR. Low toxicity was observed during the treatment. Among the hematological toxicities, neutropenia was the most common. There was no nonhematological toxicity with a degree higher than 1/2 during the treatment. Moreover, it has been found that better effects and fewer side effects are obtained when ropeginterferon is administered for a longer time, but in lower doses. The comparison of the effectiveness of interferon in chronic myeloproliferative disorders based on selected articles is presented in Table 1 [51].
Source | Type of trial | Interferon | Diagnosis | No. | Prior treatment status | Response rate |
---|---|---|---|---|---|---|
Yacoubet al. [15] | Phase II, multicenter | Pegylated IFN alfa-2a | PV | 50 | Resistance to HU or HU intolerance | CR:22% PR:38% |
ET | 65 | CR:43% PR:26% | ||||
Masarova et al. [16] | Phase II, single-center | Pegylated IFN alfa-2a | PV | 43 | Untreated or previously treated with cytoreductive therapy | CR:77% PR:7% |
ET | 40 | CR:73% PR:3% | ||||
Samuelsson et al. [18] | Phase II | Pegylated IFN alfa-2b | PV | 21 | Untreated or previously treated with cytoreductive therapy | CR: 69% for the entire group |
ET | 21 | |||||
Huang BT et al. [19] | Open label, multicenter | IFN alfa-2b | PV | 136 | Untreated or previously treated with cytoreductive therapy | OHR:70% Molecular response:54.7% |
ET | 123 | OHR (JAK2+ patients):83% CHR:23 cases OHR (JAK2-patients): 61.4% CHR:12 cases | ||||
Gisslinger et al. [23] | phase III, multicenter | Ropeginterferon | PV | 257 | Previously treated | OHR:53% |
Quintás-Cardama et al. [26] | phase II | Pegylated IFN alfa-2a | PV | 40 | Untreated or previously treated with cytoreductive therapy | OHR:80% CR:70% Molecular remission:54% |
ET | 39 | OHR:81% CR:76% Molecular remission:38% | ||||
Sørensen et al. [36] | Phase III, multicenter, COMBI | Pegylated IFN alfa-2a with ruxolitinib or Pegylated IFN alfa-2b with ruxolitinib | PV | 32 | Untreated or previously treated with cytoreductive therapy | OHR:44% CR:28% |
MF | 18 | OHR:31% CR:9% | ||||
Casassus et al. [40] | Open label, multicenter | IFN alpha-2b | Mastocytosis | 20 | Untreated and previously treated | PR:35% Minor remission: 30% |
Comparison of the effectiveness of interferon in chronic myeloproliferative disorders.
PV: polycythemia vera; ET: essential thrombocythemia; MF: myelofibrosis; HU: hydroxycarbamide/hydroxyurea; CR: complete remission; PR: partial remission; and OHR: overall hematological response.
Interferon alpha appears to be an effective and safe drug in the most type of chronic myeloproliferative disorders. Nowadays, all forms of its using have similar effectiveness. Interferon alpha can be effective even in cases of resistance for first-line treatment. Trial research is currently underway to combine it with some new drugs, such as ruxolitinib, and to add it to the already well-established therapy, it is a promising option for patients with refractory disease.
From time to time, new forms of interferon, such as ropeginterferon, are introduced, which gives hope for better effectiveness, better safety profile, and greater comfort in its use for patients who have to be treated for many years. In the case of the use of interferons alpha in the treatment of chronic myeloproliferative diseases, there are still opportunities to extend its use and to study its combination with newly introduced drugs.
"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges".
\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.
",metaTitle:"About Open Access",metaDescription:"Open access contributes to scientific excellence and integrity. It opens up research results to wider analysis. It allows research results to be reused for new discoveries. And it enables the multi-disciplinary research that is needed to solve global 21st century problems. Open access connects science with society. It allows the public to engage with research. To go behind the headlines. And look at the scientific evidence. And it enables policy makers to draw on innovative solutions to societal challenges.\n\nCarlos Moedas, the European Commissioner for Research Science and Innovation at the STM Annual Frankfurt Conference, October 2016.",metaKeywords:null,canonicalURL:"about-open-access",contentRaw:'[{"type":"htmlEditorComponent","content":"The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\\n\\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\\n\\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\\n\\nOAI-PMH
\\n\\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\\n\\nLicense
\\n\\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\\n\\nPeer Review Policies
\\n\\nAll scientific works are Peer Reviewed prior to publishing. Read more
\\n\\nOA Publishing Fees
\\n\\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\\n\\nDigital Archiving Policy
\\n\\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\\n\\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\\n\\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\\n\\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\\n\\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
\\n\\n\\n"}]'},components:[{type:"htmlEditorComponent",content:'
The Open Access publishing movement started in the early 2000s when academic leaders from around the world participated in the formation of the Budapest Initiative. They developed recommendations for an Open Access publishing process, “which has worked for the past decade to provide the public with unrestricted, free access to scholarly research—much of which is publicly funded. Making the research publicly available to everyone—free of charge and without most copyright and licensing restrictions—will accelerate scientific research efforts and allow authors to reach a larger number of readers” (reference: http://www.budapestopenaccessinitiative.org)
\n\nIntechOpen’s co-founders, both scientists themselves, created the company while undertaking research in robotics at Vienna University. Their goal was to spread research freely “for scientists, by scientists’ to the rest of the world via the Open Access publishing model. The company soon became a signatory of the Budapest Initiative, which currently has more than 1000 supporting organizations worldwide, ranging from universities to funders.
\n\nAt IntechOpen today, we are still as committed to working with organizations and people who care about scientific discovery, to putting the academic needs of the scientific community first, and to providing an Open Access environment where scientists can maximize their contribution to scientific advancement. By opening up access to the world’s scientific research articles and book chapters, we aim to facilitate greater opportunity for collaboration, scientific discovery and progress. We subscribe wholeheartedly to the Open Access definition:
\n\n“By “open access” to [peer-reviewed research literature], we mean its free availability on the public internet, permitting any users to read, download, copy, distribute, print, search, or link to the full texts of these articles, crawl them for indexing, pass them as data to software, or use them for any other lawful purpose, without financial, legal, or technical barriers other than those inseparable from gaining access to the internet itself. The only constraint on reproduction and distribution, and the only role for copyright in this domain, should be to give authors control over the integrity of their work and the right to be properly acknowledged and cited” (reference: http://www.budapestopenaccessinitiative.org)
\n\nOAI-PMH
\n\nAs a firm believer in the wider dissemination of knowledge, IntechOpen supports the Open Access Initiative Protocol for Metadata Harvesting (OAI-PMH Version 2.0). Read more
\n\nLicense
\n\nBook chapters published in edited volumes are distributed under the Creative Commons Attribution 3.0 Unported License (CC BY 3.0). IntechOpen upholds a very flexible Copyright Policy. There is no copyright transfer to the publisher and Authors retain exclusive copyright to their work. All Monographs/Compacts are distributed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Read more
\n\nPeer Review Policies
\n\nAll scientific works are Peer Reviewed prior to publishing. Read more
\n\nOA Publishing Fees
\n\nThe Open Access publishing model employed by IntechOpen eliminates subscription charges and pay-per-view fees, enabling readers to access research at no cost. In order to sustain operations and keep our publications freely accessible we levy an Open Access Publishing Fee for manuscripts, which helps us cover the costs of editorial work and the production of books. Read more
\n\nDigital Archiving Policy
\n\nIntechOpen is committed to ensuring the long-term preservation and the availability of all scholarly research we publish. We employ a variety of means to enable us to deliver on our commitments to the scientific community. Apart from preservation by the Croatian National Library (for publications prior to April 18, 2018) and the British Library (for publications after April 18, 2018), our entire catalogue is preserved in the CLOCKSS archive.
\n\nOpen Science is transparent and accessible knowledge that is shared and developed through collaborative networks.
\n\nOpen Science is about increased rigour, accountability, and reproducibility for research. It is based on the principles of inclusion, fairness, equity, and sharing, and ultimately seeks to change the way research is done, who is involved and how it is valued. It aims to make research more open to participation, review/refutation, improvement and (re)use for the world to benefit.
\n\nOpen Science refers to doing traditional science with more transparency involved at various stages, for example by openly sharing code and data. It implies a growing set of practices - within different disciplines - aiming at:
\n\nWe aim at improving the quality and availability of scholarly communication by promoting and practicing:
\n\n\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. He has contributed in stochastic estimation of control area especially, in the Multiple Target Tracking and Interactive Multiple Model (IMM) research, Ball & Beam Control Problem, Robotics, Levitation Control. He has contributed in developing Algorithms for Fingerprint Matching, Computer Vision and Face Recognition. He has been supervising Pattern Recognition, Formal Languages and Distributed Processing projects for several years. He has reviewed many books on Management, Computer Science. Currently, he is an active and permanent reviewer for many international conferences and symposia and the program committee member for many international conferences.\nIn teaching he has taught the core computer science subjects like, Digital Design, Real Time Embedded System Programming, Operating Systems, Software Engineering, Data Structures, Databases, Compiler Construction. In the Engineering side, Digital Signal Processing, Computer Architecture, Electronics Devices, Digital Filtering and Engineering Management.\nApart from his Academic Interest and activities he loves sport especially, Cricket, Football, Snooker and Squash. He plays cricket for Esbjerg city in the second division team as an opener wicket keeper batsman. He is a very good player of squash but has not played squash since his arrival in Denmark.",institutionString:null,institution:null},{id:"611",title:"Prof.",name:"T",middleName:null,surname:"Nagarajan",slug:"t-nagarajan",fullName:"T Nagarajan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universiti Teknologi Petronas",country:{name:"Malaysia"}}}],filtersByRegion:[{group:"region",caption:"North America",value:1,count:13389},{group:"region",caption:"Middle and South America",value:2,count:11661},{group:"region",caption:"Africa",value:3,count:4168},{group:"region",caption:"Asia",value:4,count:22334},{group:"region",caption:"Australia and Oceania",value:5,count:2019},{group:"region",caption:"Europe",value:6,count:33642}],offset:12,limit:12,total:135277},chapterEmbeded:{data:{}},editorApplication:{success:null,errors:{}},ofsBooks:{filterParams:{hasNoEditors:"0",sort:"dateEndThirdStepPublish",topicId:"8910111415202224"},books:[],filtersByTopic:[{group:"topic",caption:"Agricultural and Biological Sciences",value:5,count:24},{group:"topic",caption:"Biochemistry, Genetics and Molecular Biology",value:6,count:7},{group:"topic",caption:"Business, Management and Economics",value:7,count:4},{group:"topic",caption:"Chemistry",value:8,count:16},{group:"topic",caption:"Computer and Information Science",value:9,count:18},{group:"topic",caption:"Earth and Planetary Sciences",value:10,count:8},{group:"topic",caption:"Engineering",value:11,count:39},{group:"topic",caption:"Environmental Sciences",value:12,count:5},{group:"topic",caption:"Immunology and Microbiology",value:13,count:8},{group:"topic",caption:"Materials Science",value:14,count:15},{group:"topic",caption:"Mathematics",value:15,count:9},{group:"topic",caption:"Medicine",value:16,count:64},{group:"topic",caption:"Nanotechnology and Nanomaterials",value:17,count:2},{group:"topic",caption:"Neuroscience",value:18,count:3},{group:"topic",caption:"Pharmacology, Toxicology and Pharmaceutical Science",value:19,count:7},{group:"topic",caption:"Physics",value:20,count:5},{group:"topic",caption:"Psychology",value:21,count:5},{group:"topic",caption:"Robotics",value:22,count:2},{group:"topic",caption:"Social Sciences",value:23,count:8},{group:"topic",caption:"Veterinary Medicine and Science",value:25,count:2}],offset:12,limit:12,total:0},popularBooks:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3737",title:"MATLAB",subtitle:"Modelling, Programming and Simulations",isOpenForSubmission:!1,hash:null,slug:"matlab-modelling-programming-and-simulations",bookSignature:"Emilson Pereira Leite",coverURL:"https://cdn.intechopen.com/books/images_new/3737.jpg",editors:[{id:"12051",title:"Prof.",name:"Emilson",middleName:null,surname:"Pereira Leite",slug:"emilson-pereira-leite",fullName:"Emilson Pereira Leite"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"1770",title:"Gel Electrophoresis",subtitle:"Principles and Basics",isOpenForSubmission:!1,hash:"279701f6c802cf02deef45103e0611ff",slug:"gel-electrophoresis-principles-and-basics",bookSignature:"Sameh Magdeldin",coverURL:"https://cdn.intechopen.com/books/images_new/1770.jpg",editors:[{id:"123648",title:"Dr.",name:"Sameh",middleName:null,surname:"Magdeldin",slug:"sameh-magdeldin",fullName:"Sameh Magdeldin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],offset:12,limit:12,total:4797},hotBookTopics:{hotBooks:[],offset:0,limit:12,total:null},publish:{},publishingProposal:{success:null,errors:{}},books:{featuredBooks:[{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",publishedDate:"July 27th 2022",numberOfDownloads:7175,editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1981,editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10796",title:"Extracellular Vesicles",subtitle:"Role in Diseases, Pathogenesis and Therapy",isOpenForSubmission:!1,hash:"eb5407fcf93baff7bca3fae5640153a2",slug:"extracellular-vesicles-role-in-diseases-pathogenesis-and-therapy",bookSignature:"Manash K. Paul",coverURL:"https://cdn.intechopen.com/books/images_new/10796.jpg",publishedDate:"July 20th 2022",numberOfDownloads:2308,editors:[{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",publishedDate:"July 27th 2022",numberOfDownloads:1473,editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"95",title:"Applications and Experiences of Quality Control",subtitle:null,isOpenForSubmission:!1,hash:"4bcb22b1eee68210a977a97d5a0f363a",slug:"applications-and-experiences-of-quality-control",bookSignature:"Ognyan Ivanov",coverURL:"https://cdn.intechopen.com/books/images_new/95.jpg",publishedDate:"April 26th 2011",numberOfDownloads:318571,editors:[{id:"22230",title:"Prof.",name:"Ognyan",middleName:null,surname:"Ivanov",slug:"ognyan-ivanov",fullName:"Ognyan Ivanov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"2160",title:"MATLAB",subtitle:"A Fundamental Tool for Scientific Computing and Engineering Applications - Volume 1",isOpenForSubmission:!1,hash:"dd9c658341fbd264ed4f8d9e6aa8ca29",slug:"matlab-a-fundamental-tool-for-scientific-computing-and-engineering-applications-volume-1",bookSignature:"Vasilios N. Katsikis",coverURL:"https://cdn.intechopen.com/books/images_new/2160.jpg",publishedDate:"September 26th 2012",numberOfDownloads:271836,editors:[{id:"12289",title:"Prof.",name:"Vasilios",middleName:"N.",surname:"Katsikis",slug:"vasilios-katsikis",fullName:"Vasilios Katsikis"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3560",title:"Advances in Landscape Architecture",subtitle:null,isOpenForSubmission:!1,hash:"a20614517ec5f7e91188fe8e42832138",slug:"advances-in-landscape-architecture",bookSignature:"Murat Özyavuz",coverURL:"https://cdn.intechopen.com/books/images_new/3560.jpg",publishedDate:"July 1st 2013",numberOfDownloads:243450,editors:[{id:"93073",title:"Dr.",name:"Murat",middleName:null,surname:"Ozyavuz",slug:"murat-ozyavuz",fullName:"Murat Ozyavuz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10739",title:"Global Decline of Insects",subtitle:null,isOpenForSubmission:!1,hash:"543783652b9092962a8fa4bed38eeb17",slug:"global-decline-of-insects",bookSignature:"Hamadttu Abdel Farag El-Shafie",coverURL:"https://cdn.intechopen.com/books/images_new/10739.jpg",publishedDate:"July 20th 2022",numberOfDownloads:1582,editors:[{id:"192142",title:"Dr.",name:"Hamadttu",middleName:null,surname:"Abdel Farag El-Shafie",slug:"hamadttu-abdel-farag-el-shafie",fullName:"Hamadttu Abdel Farag El-Shafie"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"10911",title:"Higher Education",subtitle:"New Approaches to Accreditation, Digitalization, and Globalization in the Age of Covid",isOpenForSubmission:!1,hash:"223a02337498e535e967174c1f648fbc",slug:"higher-education-new-approaches-to-accreditation-digitalization-and-globalization-in-the-age-of-covid",bookSignature:"Lee Waller and Sharon Waller",coverURL:"https://cdn.intechopen.com/books/images_new/10911.jpg",publishedDate:"July 13th 2022",numberOfDownloads:2082,editors:[{id:"263301",title:"Dr.",name:"Lee",middleName:null,surname:"Waller",slug:"lee-waller",fullName:"Lee Waller"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}},{type:"book",id:"3568",title:"Recent Advances in Plant in vitro Culture",subtitle:null,isOpenForSubmission:!1,hash:"830bbb601742c85a3fb0eeafe1454c43",slug:"recent-advances-in-plant-in-vitro-culture",bookSignature:"Annarita Leva and Laura M. R. Rinaldi",coverURL:"https://cdn.intechopen.com/books/images_new/3568.jpg",publishedDate:"October 17th 2012",numberOfDownloads:256294,editors:[{id:"142145",title:"Dr.",name:"Annarita",middleName:null,surname:"Leva",slug:"annarita-leva",fullName:"Annarita Leva"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter"}}],latestBooks:[{type:"book",id:"10808",title:"Current Concepts in Dental Implantology",subtitle:"From Science to Clinical Research",isOpenForSubmission:!1,hash:"4af8830e463f89c57515c2da2b9777b0",slug:"current-concepts-in-dental-implantology-from-science-to-clinical-research",bookSignature:"Dragana Gabrić and Marko Vuletić",coverURL:"https://cdn.intechopen.com/books/images_new/10808.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"26946",title:"Prof.",name:"Dragana",middleName:null,surname:"Gabrić",slug:"dragana-gabric",fullName:"Dragana Gabrić"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11328",title:"Botulinum Toxin",subtitle:"Recent Topics and Applications",isOpenForSubmission:!1,hash:"7dd05a316001cef143e209eda51387a7",slug:"botulinum-toxin-recent-topics-and-applications",bookSignature:"Suna Sabuncuoglu",coverURL:"https://cdn.intechopen.com/books/images_new/11328.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"270856",title:"Associate Prof.",name:"Suna",middleName:null,surname:"Sabuncuoglu",slug:"suna-sabuncuoglu",fullName:"Suna Sabuncuoglu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11085",title:"Polycystic Ovary Syndrome",subtitle:"Functional Investigation and Clinical Application",isOpenForSubmission:!1,hash:"3066dd3ff29e1fac072fd60b08d4d3e7",slug:"polycystic-ovary-syndrome-functional-investigation-and-clinical-application",bookSignature:"Zhengchao Wang",coverURL:"https://cdn.intechopen.com/books/images_new/11085.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"204883",title:"Dr.",name:"Zhengchao",middleName:null,surname:"Wang",slug:"zhengchao-wang",fullName:"Zhengchao Wang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10833",title:"Tumor Angiogenesis and Modulators",subtitle:null,isOpenForSubmission:!1,hash:"f29b575c46128b2da061ef7f9bd1070b",slug:"tumor-angiogenesis-and-modulators",bookSignature:"Ke Xu",coverURL:"https://cdn.intechopen.com/books/images_new/10833.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"59529",title:"Dr.",name:"Ke",middleName:null,surname:"Xu",slug:"ke-xu",fullName:"Ke Xu"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11356",title:"Molecular Cloning",subtitle:null,isOpenForSubmission:!1,hash:"671c629dd86e97f0fb467b9e70e92296",slug:"molecular-cloning",bookSignature:"Sadık Dincer, Hatice Aysun Mercimek Takcı and Melis Sumengen Ozdenef",coverURL:"https://cdn.intechopen.com/books/images_new/11356.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"188141",title:"Prof.",name:"Sadik",middleName:null,surname:"Dincer",slug:"sadik-dincer",fullName:"Sadik Dincer"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7827",title:"Interpersonal Relationships",subtitle:null,isOpenForSubmission:!1,hash:"ebf41f4d17c75010eb3294cc8cac3d47",slug:"interpersonal-relationships",bookSignature:"Martha Peaslee Levine",coverURL:"https://cdn.intechopen.com/books/images_new/7827.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"186919",title:"Dr.",name:"Martha",middleName:null,surname:"Peaslee Levine",slug:"martha-peaslee-levine",fullName:"Martha Peaslee Levine"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10908",title:"Advances in Decision Making",subtitle:null,isOpenForSubmission:!1,hash:"126486f7f91e18e2e3539a32c38be7b1",slug:"advances-in-decision-making",bookSignature:"Fausto Pedro García Márquez",coverURL:"https://cdn.intechopen.com/books/images_new/10908.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"22844",title:"Prof.",name:"Fausto Pedro",middleName:null,surname:"García Márquez",slug:"fausto-pedro-garcia-marquez",fullName:"Fausto Pedro García Márquez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10669",title:"Corrosion",subtitle:"Fundamentals and Protection Mechanisms",isOpenForSubmission:!1,hash:"4a76d54f8a40fc2e7002a8d13fd617c1",slug:"corrosion-fundamentals-and-protection-mechanisms",bookSignature:"Fahmina Zafar, Anujit Ghosal and Eram Sharmin",coverURL:"https://cdn.intechopen.com/books/images_new/10669.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"89672",title:"Dr.",name:"Fahmina",middleName:null,surname:"Zafar",slug:"fahmina-zafar",fullName:"Fahmina Zafar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10677",title:"Advanced Topics of Topology",subtitle:null,isOpenForSubmission:!1,hash:"bf964c52f9e653fac20a7fcab58070e5",slug:"advanced-topics-of-topology",bookSignature:"Francisco Bulnes",coverURL:"https://cdn.intechopen.com/books/images_new/10677.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"92918",title:"Dr.",name:"Francisco",middleName:null,surname:"Bulnes",slug:"francisco-bulnes",fullName:"Francisco Bulnes"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"11195",title:"Recent Advances in Biometrics",subtitle:null,isOpenForSubmission:!1,hash:"2d32e33e0f499cb5241734bb75dd2a83",slug:"recent-advances-in-biometrics",bookSignature:"Muhammad Sarfraz",coverURL:"https://cdn.intechopen.com/books/images_new/11195.jpg",editedByType:"Edited by",publishedDate:"July 27th 2022",editors:[{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},subject:{topic:{id:"106",title:"Natural Disaster",slug:"natural-disaster",parent:{id:"10",title:"Earth and Planetary Sciences",slug:"earth-and-planetary-sciences"},numberOfBooks:10,numberOfSeries:0,numberOfAuthorsAndEditors:190,numberOfWosCitations:419,numberOfCrossrefCitations:302,numberOfDimensionsCitations:641,videoUrl:null,fallbackUrl:null,description:null},booksByTopicFilter:{topicId:"106",sort:"-publishedDate",limit:12,offset:0},booksByTopicCollection:[{type:"book",id:"8979",title:"Tsunami",subtitle:"Damage Assessment and Medical Triage",isOpenForSubmission:!1,hash:"6c1406cbfe8404151d13f3d7236d38fa",slug:"tsunami-damage-assessment-and-medical-triage",bookSignature:"Mohammad Mokhtari",coverURL:"https://cdn.intechopen.com/books/images_new/8979.jpg",editedByType:"Edited by",editors:[{id:"52451",title:"Dr.",name:"Mohammad",middleName:null,surname:"Mokhtari",slug:"mohammad-mokhtari",fullName:"Mohammad Mokhtari"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"9983",title:"Flood Impact Mitigation and Resilience Enhancement",subtitle:null,isOpenForSubmission:!1,hash:"ce1f62165377d01892a7c7f1b17e43c9",slug:"flood-impact-mitigation-and-resilience-enhancement",bookSignature:"Guangwei Huang",coverURL:"https://cdn.intechopen.com/books/images_new/9983.jpg",editedByType:"Edited by",editors:[{id:"262657",title:"Prof.",name:"Guangwei",middleName:null,surname:"Huang",slug:"guangwei-huang",fullName:"Guangwei Huang"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8011",title:"Natural Hazards",subtitle:"Risk, Exposure, Response, and Resilience",isOpenForSubmission:!1,hash:"43ca8c43ab0963f6c43350764f696b63",slug:"natural-hazards-risk-exposure-response-and-resilience",bookSignature:"John P. Tiefenbacher",coverURL:"https://cdn.intechopen.com/books/images_new/8011.jpg",editedByType:"Edited by",editors:[{id:"73876",title:"Dr.",name:"John P.",middleName:null,surname:"Tiefenbacher",slug:"john-p.-tiefenbacher",fullName:"John P. Tiefenbacher"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6821",title:"Natural Hazards",subtitle:"Risk Assessment and Vulnerability Reduction",isOpenForSubmission:!1,hash:"855e55f0cd51410f7013bb47181d3321",slug:"natural-hazards-risk-assessment-and-vulnerability-reduction",bookSignature:"José Simão Antunes do Carmo",coverURL:"https://cdn.intechopen.com/books/images_new/6821.jpg",editedByType:"Edited by",editors:[{id:"67904",title:"Prof.",name:"José Simão",middleName:null,surname:"Antunes Do Carmo",slug:"jose-simao-antunes-do-carmo",fullName:"José Simão Antunes Do Carmo"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6018",title:"Flood Risk Management",subtitle:null,isOpenForSubmission:!1,hash:"e1c40b989aeffdd119ee3876621fa35d",slug:"flood-risk-management",bookSignature:"Theodore Hromadka and Prasada Rao",coverURL:"https://cdn.intechopen.com/books/images_new/6018.jpg",editedByType:"Edited by",editors:[{id:"181008",title:"Dr.",name:"Theodore V.",middleName:"V.",surname:"Hromadka II",slug:"theodore-v.-hromadka-ii",fullName:"Theodore V. Hromadka II"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"5499",title:"Earthquakes",subtitle:"Tectonics, Hazard and Risk Mitigation",isOpenForSubmission:!1,hash:"a02b8c4079277fc2301b3fac46856ca4",slug:"earthquakes-tectonics-hazard-and-risk-mitigation",bookSignature:"Taher Zouaghi",coverURL:"https://cdn.intechopen.com/books/images_new/5499.jpg",editedByType:"Edited by",editors:[{id:"39860",title:"Dr.",name:"Taher",middleName:null,surname:"Zouaghi",slug:"taher-zouaghi",fullName:"Taher Zouaghi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3507",title:"Natural Disasters",subtitle:"Multifaceted Aspects in Management and Impact Assessment",isOpenForSubmission:!1,hash:"3608e266119f43880a9067fc25deaa4c",slug:"natural-disasters-multifaceted-aspects-in-management-and-impact-assessment",bookSignature:"Olga Petrucci",coverURL:"https://cdn.intechopen.com/books/images_new/3507.jpg",editedByType:"Edited by",editors:[{id:"76678",title:"Dr.",name:"Olga",middleName:null,surname:"Petrucci",slug:"olga-petrucci",fullName:"Olga Petrucci"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3088",title:"Updates in Volcanology",subtitle:"New Advances in Understanding Volcanic Systems",isOpenForSubmission:!1,hash:"16d9b1a78c646969f6405d7e17039df5",slug:"updates-in-volcanology-new-advances-in-understanding-volcanic-systems",bookSignature:"Karoly Nemeth",coverURL:"https://cdn.intechopen.com/books/images_new/3088.jpg",editedByType:"Edited by",editors:[{id:"51162",title:"Dr.",name:"Károly",middleName:null,surname:"Németh",slug:"karoly-nemeth",fullName:"Károly Németh"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"600",title:"Approaches to Managing Disaster",subtitle:"Assessing Hazards, Emergencies and Disaster Impacts",isOpenForSubmission:!1,hash:"e97caba8487382025a1e70eb85e4e390",slug:"approaches-to-managing-disaster-assessing-hazards-emergencies-and-disaster-impacts",bookSignature:"John Tiefenbacher",coverURL:"https://cdn.intechopen.com/books/images_new/600.jpg",editedByType:"Edited by",editors:[{id:"73876",title:"Dr.",name:"John P.",middleName:null,surname:"Tiefenbacher",slug:"john-p.-tiefenbacher",fullName:"John P. Tiefenbacher"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"863",title:"Natural Disasters",subtitle:null,isOpenForSubmission:!1,hash:"7d03632c95c81e3de1eba473b9975204",slug:"natural-disasters",bookSignature:"Sorin Cheval",coverURL:"https://cdn.intechopen.com/books/images_new/863.jpg",editedByType:"Edited by",editors:[{id:"123456",title:"Dr.",name:"Sorin",middleName:null,surname:"Cheval",slug:"sorin-cheval",fullName:"Sorin Cheval"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],booksByTopicTotal:10,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"31818",doi:"10.5772/28441",title:"Comprehensive Monitoring of Wildfires in Europe: The European Forest Fire Information System (EFFIS)",slug:"comprehensive-monitoring-of-wildfires-in-europe-the-european-forest-fire-information-system-effis-",totalDownloads:4546,totalCrossrefCites:74,totalDimensionsCites:167,abstract:null,book:{id:"600",slug:"approaches-to-managing-disaster-assessing-hazards-emergencies-and-disaster-impacts",title:"Approaches to Managing Disaster",fullTitle:"Approaches to Managing Disaster - Assessing Hazards, Emergencies and Disaster Impacts"},signatures:"Jesús San-Miguel-Ayanz, Ernst Schulte, Guido Schmuck, Andrea Camia, Peter Strobl, Giorgio Liberta, Cristiano Giovando, Roberto Boca, Fernando Sedano, Pieter Kempeneers, Daniel McInerney, Ceri Withmore, Sandra Santos de Oliveira, Marcos Rodrigues, Tracy Durrant, Paolo Corti, Friderike Oehler, Lara Vilar and Giuseppe Amatulli",authors:[{id:"73894",title:"Dr.",name:"Jesús",middleName:null,surname:"San-Miguel-Ayanz",slug:"jesus-san-miguel-ayanz",fullName:"Jesús San-Miguel-Ayanz"},{id:"126055",title:"MSc.",name:"Ernst",middleName:null,surname:"Schulte",slug:"ernst-schulte",fullName:"Ernst Schulte"},{id:"126056",title:"Dr.",name:"Guido",middleName:null,surname:"Schmuck",slug:"guido-schmuck",fullName:"Guido Schmuck"},{id:"126057",title:"Dr.",name:"Andrea",middleName:null,surname:"Camia",slug:"andrea-camia",fullName:"Andrea Camia"},{id:"126058",title:"Dr.",name:"Peter",middleName:null,surname:"Strobl",slug:"peter-strobl",fullName:"Peter Strobl"},{id:"126059",title:"Mr.",name:"Giorgio",middleName:null,surname:"Liberta",slug:"giorgio-liberta",fullName:"Giorgio Liberta"},{id:"126060",title:"MSc.",name:"Cristiano",middleName:null,surname:"Giovando",slug:"cristiano-giovando",fullName:"Cristiano Giovando"},{id:"126061",title:"BSc.",name:"Roberto",middleName:null,surname:"Boca",slug:"roberto-boca",fullName:"Roberto Boca"},{id:"126062",title:"Dr.",name:"Fernando",middleName:null,surname:"Sedano",slug:"fernando-sedano",fullName:"Fernando Sedano"},{id:"126063",title:"Dr.",name:"Pieter",middleName:null,surname:"Kempeners",slug:"pieter-kempeners",fullName:"Pieter Kempeners"},{id:"126064",title:"Dr.",name:"Daniel",middleName:null,surname:"McInerney",slug:"daniel-mcinerney",fullName:"Daniel McInerney"},{id:"126066",title:"BSc.",name:"Ceri",middleName:null,surname:"Whitmore",slug:"ceri-whitmore",fullName:"Ceri Whitmore"},{id:"126068",title:"MSc.",name:"Sandra",middleName:null,surname:"Santos De Oliveira",slug:"sandra-santos-de-oliveira",fullName:"Sandra Santos De Oliveira"},{id:"126070",title:"MSc.",name:"Marcos",middleName:null,surname:"Rodrigues",slug:"marcos-rodrigues",fullName:"Marcos Rodrigues"},{id:"126072",title:"MSc.",name:"Tracy",middleName:null,surname:"Durrant",slug:"tracy-durrant",fullName:"Tracy Durrant"},{id:"126073",title:"MSc.",name:"Paolo",middleName:null,surname:"Corti",slug:"paolo-corti",fullName:"Paolo Corti"},{id:"126074",title:"MSc.",name:"Friderike",middleName:null,surname:"Oehler",slug:"friderike-oehler",fullName:"Friderike Oehler"},{id:"126075",title:"Dr.",name:"Lara",middleName:null,surname:"Vilar",slug:"lara-vilar",fullName:"Lara Vilar"},{id:"126076",title:"Dr.",name:"Giuseppe",middleName:null,surname:"Amatulli",slug:"giuseppe-amatulli",fullName:"Giuseppe Amatulli"}]},{id:"41478",doi:"10.5772/51387",title:"Monogenetic Basaltic Volcanoes: Genetic Classification, Growth, Geomorphology and Degradation",slug:"monogenetic-basaltic-volcanoes-genetic-classification-growth-geomorphology-and-degradation",totalDownloads:6196,totalCrossrefCites:71,totalDimensionsCites:143,abstract:null,book:{id:"3088",slug:"updates-in-volcanology-new-advances-in-understanding-volcanic-systems",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - New Advances in Understanding Volcanic Systems"},signatures:"Gábor Kereszturi and Károly Németh",authors:[{id:"51162",title:"Dr.",name:"Károly",middleName:null,surname:"Németh",slug:"karoly-nemeth",fullName:"Károly Németh"},{id:"62029",title:"Dr.",name:"Gabor",middleName:null,surname:"Kereszturi",slug:"gabor-kereszturi",fullName:"Gabor Kereszturi"}]},{id:"38733",doi:"10.5772/51270",title:"An Overview of Mud Volcanoes Associated to Gas Hydrate System",slug:"an-overview-of-mud-volcanoes-associated-to-gas-hydrate-system",totalDownloads:3993,totalCrossrefCites:13,totalDimensionsCites:22,abstract:null,book:{id:"3088",slug:"updates-in-volcanology-new-advances-in-understanding-volcanic-systems",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - New Advances in Understanding Volcanic Systems"},signatures:"Umberta Tinivella and Michela Giustiniani",authors:[{id:"151612",title:"Dr.",name:"Umberta",middleName:null,surname:"Tinivella",slug:"umberta-tinivella",fullName:"Umberta Tinivella"},{id:"151614",title:"Dr.",name:"Michela",middleName:null,surname:"Giustiniani",slug:"michela-giustiniani",fullName:"Michela Giustiniani"}]},{id:"52524",doi:"10.5772/65425",title:"Earthquakes and Structural Damages",slug:"earthquakes-and-structural-damages",totalDownloads:3391,totalCrossrefCites:14,totalDimensionsCites:21,abstract:"Earthquakes are the most destructive natural hazards throughout human history. Hundreds of thousand people lost their lives and loss of billions of dollars’ properties occurred in these disasters. Occurred medium or high-intensity magnitude earthquakes in last twenty years showed that these loses continue. For reinforced concrete (R/C) buildings, inappropriate design such as soft and weak stories, strong beam–weak column, short column, hammering, unconfined gable wall and in-plane/out-of-plane movement of the walls causes damages. These are the main reasons. In addition to this, low quality of structural materials, poor workmanship, lack of engineering services, and construction with insufficient detailing of the structural elements are the another reasons of damages. Main reasons of masonry building damages in terms of design faults can be shown as heavy earthen roofs, inappropriate detailing of wall to wall connection and wall to roof connection, absence of bond beams, large openings. However, construction of buildings by using local materials with poor workmanship on the base of traditional rules is the other reason of failures for these buildings. In this book chapter, earthquakes and reasons of damages arose from earthquakes for reinforced concrete and masonry structures were presented. In addition to this, appropriate solutions are suggested.",book:{id:"5499",slug:"earthquakes-tectonics-hazard-and-risk-mitigation",title:"Earthquakes",fullTitle:"Earthquakes - Tectonics, Hazard and Risk Mitigation"},signatures:"Burak Yön, Erkut Sayın and Onur Onat",authors:[{id:"192483",title:"Dr.",name:"Burak",middleName:null,surname:"Yön",slug:"burak-yon",fullName:"Burak Yön"},{id:"192486",title:"Dr.",name:"Erkut",middleName:null,surname:"Sayın",slug:"erkut-sayin",fullName:"Erkut Sayın"},{id:"192487",title:"Dr.",name:"Onur",middleName:null,surname:"Onat",slug:"onur-onat",fullName:"Onur Onat"}]},{id:"52565",doi:"10.5772/65511",title:"Earthquake Prediction",slug:"earthquake-prediction",totalDownloads:2049,totalCrossrefCites:11,totalDimensionsCites:21,abstract:"Among the countless natural disasters, earthquakes are capable to inflict vast devastation to a large number of buildings and constructions at the blink of an eye. Lack of knowledge and awareness on earthquake as well as its comeback is conspicuous and results in disaster; leading to bitter memories. Therefore, earthquake forecast has been a polemical study theme that has defied even the most intelligent of minds. In this chapter, an attempt was made to do an extensive overview in the area of the earthquake prediction as well as classifying them into the main strategies comprising short‐, immediate‐, and long‐term prediction. An example of each strategy was carried out by mentioning their corresponding approaches/algorithms, such as ΔCFS, CN, MSc, M8, ANN, FFBPANN, KNN, GRNN, RBF, and LMBP; depending on the importance of each strategy. Based on these, it was concluded that, after the Tohoku‐Oki earthquake with M9.0, the current orientation of the Headquarters for earthquake Research Promotion of MEXT in Japan declare that, their mission would be long‐term statistical forecast of seismicity. Even, it is claimed that they do not emphasize on short‐term forecasting. Besides, intermediate‐term estimations are not capable to be used for prevention of all damages and protect all human life, but they may be utilized to undertake certain affordable activities to decrease damage, losses, and modify postdisaster relief. And, despite the long‐term prediction is more concerned by researchers, there is no certain satisfactory level to content them. De facto, the made covenant of 1970 that investigators will be capable to forecast/predict ground excitations within a decade, still remains unmet.",book:{id:"5499",slug:"earthquakes-tectonics-hazard-and-risk-mitigation",title:"Earthquakes",fullTitle:"Earthquakes - Tectonics, Hazard and Risk Mitigation"},signatures:"Khaled Ghaedi and Zainah Ibrahim",authors:[{id:"190572",title:"Dr.",name:"Khaled",middleName:null,surname:"Ghaedi",slug:"khaled-ghaedi",fullName:"Khaled Ghaedi"},{id:"196228",title:"Prof.",name:"Zainah",middleName:null,surname:"Ibrahim",slug:"zainah-ibrahim",fullName:"Zainah Ibrahim"}]}],mostDownloadedChaptersLast30Days:[{id:"41664",title:"Volcanic Natural Resources and Volcanic Landscape Protection: An Overview",slug:"volcanic-natural-resources-and-volcanic-landscape-protection-an-overview",totalDownloads:3782,totalCrossrefCites:2,totalDimensionsCites:4,abstract:null,book:{id:"3088",slug:"updates-in-volcanology-new-advances-in-understanding-volcanic-systems",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - New Advances in Understanding Volcanic Systems"},signatures:"Jiaqi Liu, Jiali Liu, Xiaoyu Chen and Wenfeng Guo",authors:[{id:"60000",title:"Prof.",name:"Jiaqi",middleName:null,surname:"Liu",slug:"jiaqi-liu",fullName:"Jiaqi Liu"}]},{id:"31815",title:"Disaster Management Based on Business Process Model Through the Plant Lifecycle",slug:"disaster-management-based-on-business-process-model-through-the-plant-lifecycle",totalDownloads:2727,totalCrossrefCites:6,totalDimensionsCites:10,abstract:null,book:{id:"600",slug:"approaches-to-managing-disaster-assessing-hazards-emergencies-and-disaster-impacts",title:"Approaches to Managing Disaster",fullTitle:"Approaches to Managing Disaster - Assessing Hazards, Emergencies and Disaster Impacts"},signatures:"Yukiyasu Shimada, Teiji Kitajima, Tetsuo Fuchino and Kazuhiro Takeda",authors:[{id:"70197",title:"Dr.",name:"Yukiyasu",middleName:null,surname:"Shimada",slug:"yukiyasu-shimada",fullName:"Yukiyasu Shimada"},{id:"82055",title:"Dr.",name:"Tetsuo",middleName:null,surname:"Fuchino",slug:"tetsuo-fuchino",fullName:"Tetsuo Fuchino"},{id:"82056",title:"Prof.",name:"Teiji",middleName:null,surname:"Kitajima",slug:"teiji-kitajima",fullName:"Teiji Kitajima"},{id:"121284",title:"Dr.",name:"Kazuhiro",middleName:null,surname:"Takeda",slug:"kazuhiro-takeda",fullName:"Kazuhiro Takeda"}]},{id:"52524",title:"Earthquakes and Structural Damages",slug:"earthquakes-and-structural-damages",totalDownloads:3388,totalCrossrefCites:14,totalDimensionsCites:21,abstract:"Earthquakes are the most destructive natural hazards throughout human history. Hundreds of thousand people lost their lives and loss of billions of dollars’ properties occurred in these disasters. Occurred medium or high-intensity magnitude earthquakes in last twenty years showed that these loses continue. For reinforced concrete (R/C) buildings, inappropriate design such as soft and weak stories, strong beam–weak column, short column, hammering, unconfined gable wall and in-plane/out-of-plane movement of the walls causes damages. These are the main reasons. In addition to this, low quality of structural materials, poor workmanship, lack of engineering services, and construction with insufficient detailing of the structural elements are the another reasons of damages. Main reasons of masonry building damages in terms of design faults can be shown as heavy earthen roofs, inappropriate detailing of wall to wall connection and wall to roof connection, absence of bond beams, large openings. However, construction of buildings by using local materials with poor workmanship on the base of traditional rules is the other reason of failures for these buildings. In this book chapter, earthquakes and reasons of damages arose from earthquakes for reinforced concrete and masonry structures were presented. In addition to this, appropriate solutions are suggested.",book:{id:"5499",slug:"earthquakes-tectonics-hazard-and-risk-mitigation",title:"Earthquakes",fullTitle:"Earthquakes - Tectonics, Hazard and Risk Mitigation"},signatures:"Burak Yön, Erkut Sayın and Onur Onat",authors:[{id:"192483",title:"Dr.",name:"Burak",middleName:null,surname:"Yön",slug:"burak-yon",fullName:"Burak Yön"},{id:"192486",title:"Dr.",name:"Erkut",middleName:null,surname:"Sayın",slug:"erkut-sayin",fullName:"Erkut Sayın"},{id:"192487",title:"Dr.",name:"Onur",middleName:null,surname:"Onat",slug:"onur-onat",fullName:"Onur Onat"}]},{id:"41478",title:"Monogenetic Basaltic Volcanoes: Genetic Classification, Growth, Geomorphology and Degradation",slug:"monogenetic-basaltic-volcanoes-genetic-classification-growth-geomorphology-and-degradation",totalDownloads:6195,totalCrossrefCites:71,totalDimensionsCites:142,abstract:null,book:{id:"3088",slug:"updates-in-volcanology-new-advances-in-understanding-volcanic-systems",title:"Updates in Volcanology",fullTitle:"Updates in Volcanology - New Advances in Understanding Volcanic Systems"},signatures:"Gábor Kereszturi and Károly Németh",authors:[{id:"51162",title:"Dr.",name:"Károly",middleName:null,surname:"Németh",slug:"karoly-nemeth",fullName:"Károly Németh"},{id:"62029",title:"Dr.",name:"Gabor",middleName:null,surname:"Kereszturi",slug:"gabor-kereszturi",fullName:"Gabor Kereszturi"}]},{id:"62769",title:"Disaster Mitigation Model of Eruption Based on Local Wisdom in Indonesia",slug:"disaster-mitigation-model-of-eruption-based-on-local-wisdom-in-indonesia",totalDownloads:1462,totalCrossrefCites:1,totalDimensionsCites:2,abstract:"Kelud is one of the most active volcanoes in Indonesia and suffered a major eruption in 2014. Although they are not part of the super volcano, the impact of the eruption is extraordinary. However, the eruption is not too worrying for the surrounding community. The lack of disaster victims caused by the eruption in 2014 became a successful representation of disaster mitigation models owned by local communities in answering the eruption problem. The easy evacuation process and quickly post-eruption rehabilitation illustrate a pattern of environmental adaptation around the volcano. This discussion focuses on how the people behavior around the volcano in responding to the challenge of eruption? How the role of local government in preparing the community in the face of an eruption, and what actions are done so that the rehabilitation process can take place quickly? To answer all these questions, the researchers collected relevant data through observation, documentation, and interviews with the local communities and local government representatives directly involved in disaster mitigation measures. In addition, the researchers also revealed local traditions that are considered capable of supporting the process of preparing the community in answering the eruption challenges and becoming part of disaster mitigation in the volcanic region.",book:{id:"6821",slug:"natural-hazards-risk-assessment-and-vulnerability-reduction",title:"Natural Hazards",fullTitle:"Natural Hazards - Risk Assessment and Vulnerability Reduction"},signatures:"Eko Hariyono and Solaiman Liliasari",authors:[{id:"214360",title:"Dr.",name:"Eko",middleName:null,surname:"Hariyono",slug:"eko-hariyono",fullName:"Eko Hariyono"},{id:"219699",title:"Prof.",name:"Liliasari",middleName:null,surname:"S",slug:"liliasari-s",fullName:"Liliasari S"}]}],onlineFirstChaptersFilter:{topicId:"106",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81241",title:"Physiological and Molecular Adaptation of Sugarcane under Drought vis-a-vis Root System Traits",slug:"physiological-and-molecular-adaptation-of-sugarcane-under-drought-vis-a-vis-root-system-traits",totalDownloads:21,totalDimensionsCites:0,doi:"10.5772/intechopen.103795",abstract:"Among various abiotic stresses, water is reported as a rare entity in many parts of the world. Decreased frequency of precipitation and global temperature rise will further aggravate the situation in future. Being C4 plant, sugarcane requires generous water for the proper growth. Plant root system primarily supports above-ground growth by anchoring in the soil and facilitates water and nutrients uptake from the soil. The plasticity and dynamic nature of roots endow plants for the uptake of vital nutrients from the soil even under soil moisture conditions. In sugarcane, the major part of root system are generally observed in the upper soil layers, while limited water availability shifts the root growth towards the lower soil layer to sustained water uptake. In addition, root traits are directly related to physiological traits of the shoot to cope up with water limited situations via reduction in stomatal conductance and an upsurge in density and deep root traits, adaptations at biochemical and molecular level which includes osmotic adjustment and ROS detoxification. Under stressed conditions, these complex interactive systems adjust homeo-statically to minimize the adverse impacts of stress and sustain balanced metabolism. Therefore, the present chapter deals with physiological and biochemical traits along with root traits that helps for better productivity of sugarcane under water-limited conditions.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Pooja Dhansu, Arun Kumar Raja, Krishnapriya Vengavasi, Ravinder Kumar, Adhini S. Pazhany, Ashwani Kumar, Naresh Kumar, Anita Mann and Shashi Kant Pandey"},{id:"79973",title:"Impacts of Drought on Homestead Plant Diversity in Barind Tract of Bangladesh",slug:"impacts-of-drought-on-homestead-plant-diversity-in-barind-tract-of-bangladesh",totalDownloads:6,totalDimensionsCites:0,doi:"10.5772/intechopen.101885",abstract:"Homestead is a great place for household food access, diet, and nutrition. Drought affects homestead plant diversity and reduces production, availability, and diversity that lead toward less supply and consumption. Drought detains moisture and degrades the soil that supports plant growth. Homestead provides regular bread and income in the rural areas with an effective means for both economic and environmental well-being. People are getting a good amount of subsidiary income without any extra care and effort. In managing homestead land and drought, the household needs necessary technical and managerial training. In reducing drought effects to the homestead, action research needs to be carried out on available knowledge, effective practices, water management, and the adoption of local varieties and knowledge to develop effective homestead integration. Government initiatives, community engagement and not harming the environment, and efficient uses of water could be great solutions for the adverse effects of drought on the homestead plant diversity.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Md. Shafiqul Islam and Md. Nazrul Islam Mukul"},{id:"82110",title:"Hydrological Drought Index Based on Discharge",slug:"hydrological-drought-index-based-on-discharge",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.104625",abstract:"Drought is a natural phenomenon causing disasters and its period of occurrence can be predicted in recent times based on several methods using the same or different variables. The prediction is usually associated with the climate interactions in the form of rainfall or discharge patterns which can be analyzed using the return period. Therefore, this research was conducted in four different stages of data acquisition and validation, drought analysis method based on the data, drought prediction method based on hydrology, and sample applications to determine the debit availability in other watersheds. Historical rainfall data converted to dependable rainfall at 80% probability were used as input for the rainfall-discharge analysis while the hydrological drought analysis was conducted using the drought threshold value. Moreover, the drought was predicted using an artificial neural network model while historical data were used to verify the hydrological character of the prediction model. The results of the analysis conducted were further used to predict the water balance in different river areas due to the fact that each area has a different hydrological character. Meanwhile, the watersheds used as case research showed that the model has reliability of up to 80%.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"R. Rintis Hadiani, Bambang Suharto, Agus Suharyanto and Suhardjono"},{id:"81203",title:"Climate Change: A Real Danger to Human and Animal Survival",slug:"climate-change-a-real-danger-to-human-and-animal-survival",totalDownloads:42,totalDimensionsCites:0,doi:"10.5772/intechopen.103022",abstract:"Some countries in Southern Africa where hit by either a storm or cyclone or both in 2019 alone manifesting a changing climate. Infrastructure and cropping land was destroyed, both animal and human lives were lost due to the flooding events. Drought is a common phenomenon in this region, often occurring once in three years. This has affected food, feed and nutritional security of both humans and livestock. Saline soils unsuitable for agriculture, other animal and plant life are expanding fast due to insufficient precipitation. Soil degradation is on the rise, leaving soils with poor water holding capacity to support sustainable agriculture. Climate change is changing the environment and new pests and diseases for both crops and livestock are emerging. World governments, industries and general populace should find better ways of reducing air pollution by greenhouse gases which have a net effect of damaging the ozone layer and increasing atmospheric temperatures. At the same time, plant and animal breeding should aim at improving crop cultivars and animal breeds that resist to the constraints such as drought and heat stress brought by climate change. The human population is increasing at an alarming rate and need both food and nutritional security.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Godwill Makunde, Nation Chikumba, Walter Svinurai and Xavier Mhike"},{id:"81810",title:"Water Shortages: Cause of Water Safety in Sub-Saharan Africa",slug:"water-shortages-cause-of-water-safety-in-sub-saharan-africa",totalDownloads:27,totalDimensionsCites:0,doi:"10.5772/intechopen.103927",abstract:"This chapter highlights a high rate of water crisis across sub-Saharan Africa (SSA) despite its huge hydro-potential. Factors contributing to water stress include rainfall deficit and drought, increased water requirements, population growth, urbanization, and poverty. Coupled with the uneven distribution of water resources and mismanagement of water facilities, the gap between the demand for water and available supply has deepened. This has led almost half of the SSA population to drink water from unprotected sources. Moreover, many millions travel far distances and spend several hours daily to collect water. Children and women are mainly involved in water collection. The growing scarcity of water in Africa has a negative impact on economic growth. Besides, water shortages are at the heart of many social crises in SSA and have become directly or indirectly the first cause of death in Africa linked to waterborne diseases. The prevailing water-related diseases include malaria, typhoid fever, cholera, poliomyelitis, etc. To attain the African agenda 2063, national governments in SSA need a multidisciplinary approach integrating, supervising informal settlements of the population in urban and peri-urban areas; improving water storage capacity; increasing irrigation potential for agriculture; and having a good understanding of the epidemiology of waterborne diseases.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Chelea Matchawe, Patrice Bonny, Germaine Yandang, Huguette Cecile Yangoua Mafo and Bonglaisin J. Nsawir"},{id:"81584",title:"Reducing the Effects of Drought and Degradation of Agricultural Soils, in the Context of Climate Change, through the Application of Regenerative Ecological Technologies",slug:"reducing-the-effects-of-drought-and-degradation-of-agricultural-soils-in-the-context-of-climate-chan",totalDownloads:43,totalDimensionsCites:0,doi:"10.5772/intechopen.104446",abstract:"The agricultural sector has a limited capacity for expansion, consequently, deficient technologies based on the widespread use of synthetic chemicals have been implemented in the last decades, having a major negative impact on natural ecosystems, biodiversity, and environmental services. Desertification, land degradation, and drought, combined with human activity and environmental changes, cause important soil losses and a reduction in natural defenses against droughts and floods. The combined impact of climate change, land mismanagement and unsustainable freshwater use has long been affecting agricultural productivity, the most common cause being unsustainable land management practices. This chapter aims to briefly assess the most effective strategies for reducing the impact of climate change on agricultural crops, as well as to prevent or reverse the process of desertification and systematic loss in food quality and quantity. Regenerative management practices such as minimum tillage technologies, cover crops and mulching, inoculation with microorganisms, nutrients cycling, the balance of the organic fertilizers or foliar application help farmers in managing healthy soils, capable of growing rich and ecological crops without the use of chemical hazardous substances.",book:{id:"11131",title:"Drought - Impacts and Management",coverURL:"https://cdn.intechopen.com/books/images_new/11131.jpg"},signatures:"Eugen Popescu, Florin Nenciu and Valentin Nicolae Vladut"}],onlineFirstChaptersTotal:9},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}},{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:33,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. Dr. Beydemir is also Rector of Bilecik Şeyh Edebali University, Turkey.",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",slug:"deniz-ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",biography:"Dr. Deniz Ekinci obtained a BSc in Chemistry in 2004, MSc in Biochemistry in 2006, and PhD in Biochemistry in 2009 from Atatürk University, Turkey. He studied at Stetson University, USA, in 2007-2008 and at the Max Planck Institute of Molecular Cell Biology and Genetics, Germany, in 2009-2010. Dr. Ekinci currently works as a Full Professor of Biochemistry in the Faculty of Agriculture and is the Head of the Enzyme and Microbial Biotechnology Division, Ondokuz Mayıs University, Turkey. He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. Dr. Ekinci serves as the Editor in Chief of four international books and is involved in the Editorial Board of several international journals.",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null},{id:"17",title:"Metabolism",coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",isOpenForSubmission:!0,editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",slug:"yannis-karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",biography:"Yannis Karamanos, born in Greece in 1953, completed his pre-graduate studies at the Université Pierre et Marie Curie, Paris, then his Masters and Doctoral degree at the Université de Lille (1983). He was associate professor at the University of Limoges (1987) before becoming full professor of biochemistry at the Université d’Artois (1996). He worked on the structure-function relationships of glycoconjugates and his main project was the investigations on the biological roles of the de-N-glycosylation enzymes (Endo-N-acetyl-β-D-glucosaminidase and peptide-N4-(N-acetyl-β-glucosaminyl) asparagine amidase). From 2002 he contributes to the understanding of the Blood-brain barrier functioning using proteomics approaches. He has published more than 70 papers. His teaching areas are energy metabolism and regulation, integration and organ specialization and metabolic adaptation.",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null},{id:"18",title:"Proteomics",coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",isOpenForSubmission:!0,editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",slug:"paolo-iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",biography:"Paolo Iadarola graduated with a degree in Chemistry from the University of Pavia (Italy) in July 1972. He then worked as an Assistant Professor at the Faculty of Science of the same University until 1984. In 1985, Prof. Iadarola became Associate Professor at the Department of Biology and Biotechnologies of the University of Pavia and retired in October 2017. Since then, he has been working as an Adjunct Professor in the same Department at the University of Pavia. His research activity during the first years was primarily focused on the purification and structural characterization of enzymes from animal and plant sources. During this period, Prof. Iadarola familiarized himself with the conventional techniques used in column chromatography, spectrophotometry, manual Edman degradation, and electrophoresis). Since 1995, he has been working on: i) the determination in biological fluids (serum, urine, bronchoalveolar lavage, sputum) of proteolytic activities involved in the degradation processes of connective tissue matrix, and ii) on the identification of biological markers of lung diseases. In this context, he has developed and validated new methodologies (e.g., Capillary Electrophoresis coupled to Laser-Induced Fluorescence, CE-LIF) whose application enabled him to determine both the amounts of biochemical markers (Desmosines) in urine/serum of patients affected by Chronic Obstructive Pulmonary Disease (COPD) and the activity of proteolytic enzymes (Human Neutrophil Elastase, Cathepsin G, Pseudomonas aeruginosa elastase) in sputa of these patients. More recently, Prof. Iadarola was involved in developing techniques such as two-dimensional electrophoresis coupled to liquid chromatography/mass spectrometry (2DE-LC/MS) for the proteomic analysis of biological fluids aimed at the identification of potential biomarkers of different lung diseases. He is the author of about 150 publications (According to Scopus: H-Index: 23; Total citations: 1568- According to WOS: H-Index: 20; Total Citations: 1296) of peer-reviewed international journals. He is a Consultant Reviewer for several journals, including the Journal of Chromatography A, Journal of Chromatography B, Plos ONE, Proteomes, International Journal of Molecular Science, Biotech, Electrophoresis, and others. He is also Associate Editor of Biotech.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",slug:"simona-viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",biography:"Simona Viglio is an Associate Professor of Biochemistry at the Department of Molecular Medicine at the University of Pavia. She has been working since 1995 on the determination of proteolytic enzymes involved in the degradation process of connective tissue matrix and on the identification of biological markers of lung diseases. She gained considerable experience in developing and validating new methodologies whose applications allowed her to determine both the amount of biomarkers (Desmosine and Isodesmosine) in the urine of patients affected by COPD, and the activity of proteolytic enzymes (HNE, Cathepsin G, Pseudomonas aeruginosa elastase) in the sputa of these patients. Simona Viglio was also involved in research dealing with the supplementation of amino acids in patients with brain injury and chronic heart failure. She is presently engaged in the development of 2-DE and LC-MS techniques for the study of proteomics in biological fluids. The aim of this research is the identification of potential biomarkers of lung diseases. She is an author of about 90 publications (According to Scopus: H-Index: 23; According to WOS: H-Index: 20) on peer-reviewed journals, a member of the “Società Italiana di Biochimica e Biologia Molecolare,“ and a Consultant Reviewer for International Journal of Molecular Science, Journal of Chromatography A, COPD, Plos ONE and Nutritional Neuroscience.",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null}]},overviewPageOFChapters:{paginationCount:42,paginationItems:[{id:"82914",title:"Glance on the Critical Role of IL-23 Receptor Gene Variations in Inflammation-Induced Carcinogenesis",doi:"10.5772/intechopen.105049",signatures:"Mohammed El-Gedamy",slug:"glance-on-the-critical-role-of-il-23-receptor-gene-variations-in-inflammation-induced-carcinogenesis",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Chemokines Updates",coverURL:"https://cdn.intechopen.com/books/images_new/11672.jpg",subseries:{id:"18",title:"Proteomics"}}},{id:"82875",title:"Lipidomics as a Tool in the Diagnosis and Clinical Therapy",doi:"10.5772/intechopen.105857",signatures:"María Elizbeth Alvarez Sánchez, Erick Nolasco Ontiveros, Rodrigo Arreola, Adriana Montserrat Espinosa González, Ana María García Bores, Roberto Eduardo López Urrutia, Ignacio Peñalosa Castro, María del Socorro Sánchez Correa and Edgar Antonio Estrella Parra",slug:"lipidomics-as-a-tool-in-the-diagnosis-and-clinical-therapy",totalDownloads:7,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82440",title:"Lipid Metabolism and Associated Molecular Signaling Events in Autoimmune Disease",doi:"10.5772/intechopen.105746",signatures:"Mohan Vanditha, Sonu Das and Mathew John",slug:"lipid-metabolism-and-associated-molecular-signaling-events-in-autoimmune-disease",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Fatty Acids - Recent Advances",coverURL:"https://cdn.intechopen.com/books/images_new/11669.jpg",subseries:{id:"17",title:"Metabolism"}}},{id:"82483",title:"Oxidative Stress in Cardiovascular Diseases",doi:"10.5772/intechopen.105891",signatures:"Laura Mourino-Alvarez, Tamara Sastre-Oliva, Nerea Corbacho-Alonso and Maria G. Barderas",slug:"oxidative-stress-in-cardiovascular-diseases",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Importance of Oxidative Stress and Antioxidant System in Health and Disease",coverURL:"https://cdn.intechopen.com/books/images_new/11671.jpg",subseries:{id:"15",title:"Chemical Biology"}}}]},overviewPagePublishedBooks:{paginationCount:33,paginationItems:[{type:"book",id:"7006",title:"Biochemistry and Health Benefits of Fatty Acids",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7006.jpg",slug:"biochemistry-and-health-benefits-of-fatty-acids",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Viduranga Waisundara",hash:"c93a00abd68b5eba67e5e719f67fd20b",volumeInSeries:1,fullTitle:"Biochemistry and Health Benefits of Fatty Acids",editors:[{id:"194281",title:"Dr.",name:"Viduranga Y.",middleName:null,surname:"Waisundara",slug:"viduranga-y.-waisundara",fullName:"Viduranga Y. Waisundara",profilePictureURL:"https://mts.intechopen.com/storage/users/194281/images/system/194281.jpg",biography:"Dr. Viduranga Waisundara obtained her Ph.D. in Food Science\nand Technology from the Department of Chemistry, National\nUniversity of Singapore, in 2010. She was a lecturer at Temasek Polytechnic, Singapore from July 2009 to March 2013.\nShe relocated to her motherland of Sri Lanka and spearheaded the Functional Food Product Development Project at the\nNational Institute of Fundamental Studies from April 2013 to\nOctober 2016. She was a senior lecturer on a temporary basis at the Department of\nFood Technology, Faculty of Technology, Rajarata University of Sri Lanka. She is\ncurrently Deputy Principal of the Australian College of Business and Technology –\nKandy Campus, Sri Lanka. She is also the Global Harmonization Initiative (GHI)",institutionString:"Australian College of Business & Technology",institution:{name:"Kobe College",institutionURL:null,country:{name:"Japan"}}}]},{type:"book",id:"6820",title:"Keratin",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/6820.jpg",slug:"keratin",publishedDate:"December 19th 2018",editedByType:"Edited by",bookSignature:"Miroslav Blumenberg",hash:"6def75cd4b6b5324a02b6dc0359896d0",volumeInSeries:2,fullTitle:"Keratin",editors:[{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}}]},{type:"book",id:"7978",title:"Vitamin A",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7978.jpg",slug:"vitamin-a",publishedDate:"May 15th 2019",editedByType:"Edited by",bookSignature:"Leila Queiroz Zepka, Veridiana Vera de Rosso and Eduardo Jacob-Lopes",hash:"dad04a658ab9e3d851d23705980a688b",volumeInSeries:3,fullTitle:"Vitamin A",editors:[{id:"261969",title:"Dr.",name:"Leila",middleName:null,surname:"Queiroz Zepka",slug:"leila-queiroz-zepka",fullName:"Leila Queiroz Zepka",profilePictureURL:"https://mts.intechopen.com/storage/users/261969/images/system/261969.png",biography:"Prof. Dr. Leila Queiroz Zepka is currently an associate professor in the Department of Food Technology and Science, Federal University of Santa Maria, Brazil. She has more than fifteen years of teaching and research experience. She has published more than 550 scientific publications/communications, including 15 books, 50 book chapters, 100 original research papers, 380 research communications in national and international conferences, and 12 patents. She is a member of the editorial board of five journals and acts as a reviewer for several national and international journals. Her research interests include microalgal biotechnology with an emphasis on microalgae-based products.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",institutionURL:null,country:{name:"Brazil"}}}]},{type:"book",id:"7953",title:"Bioluminescence",subtitle:"Analytical Applications and Basic Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7953.jpg",slug:"bioluminescence-analytical-applications-and-basic-biology",publishedDate:"September 25th 2019",editedByType:"Edited by",bookSignature:"Hirobumi Suzuki",hash:"3a8efa00b71abea11bf01973dc589979",volumeInSeries:4,fullTitle:"Bioluminescence - Analytical Applications and Basic Biology",editors:[{id:"185746",title:"Dr.",name:"Hirobumi",middleName:null,surname:"Suzuki",slug:"hirobumi-suzuki",fullName:"Hirobumi Suzuki",profilePictureURL:"https://mts.intechopen.com/storage/users/185746/images/system/185746.png",biography:"Dr. Hirobumi Suzuki received his Ph.D. in 1997 from Tokyo Metropolitan University, Japan, where he studied firefly phylogeny and the evolution of mating systems. He is especially interested in the genetic differentiation pattern and speciation process that correlate to the flashing pattern and mating behavior of some fireflies in Japan. He then worked for Olympus Corporation, a Japanese manufacturer of optics and imaging products, where he was involved in the development of luminescence technology and produced a bioluminescence microscope that is currently being used for gene expression analysis in chronobiology, neurobiology, and developmental biology. Dr. Suzuki currently serves as a visiting researcher at Kogakuin University, Japan, and also a vice president of the Japan Firefly Society.",institutionString:"Kogakuin University",institution:null}]}]},openForSubmissionBooks:{paginationCount:2,paginationItems:[{id:"11474",title:"Quality of Life Interventions - Magnitude of Effect and Transferability",coverURL:"https://cdn.intechopen.com/books/images_new/11474.jpg",hash:"5a6bcdaf5ee144d043bcdab893ff9e1c",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 7th 2022",isOpenForSubmission:!0,editors:[{id:"245319",title:"Ph.D.",name:"Sage",surname:"Arbor",slug:"sage-arbor",fullName:"Sage Arbor"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{id:"11473",title:"Social Inequality - Structure and Social Processes",coverURL:"https://cdn.intechopen.com/books/images_new/11473.jpg",hash:"cefab077e403fd1695fb2946e7914942",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 13th 2022",isOpenForSubmission:!0,editors:[{id:"313341",title:"Ph.D.",name:"Yaroslava",surname:"Robles-Bykbaev",slug:"yaroslava-robles-bykbaev",fullName:"Yaroslava Robles-Bykbaev"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:21,paginationItems:[{id:"83000",title:"Purine and Pyrimidine Pathways as Antimalarial Targets",doi:"10.5772/intechopen.106468",signatures:"Yacoba V.T. Minnow and Vern L. Schramm",slug:"purine-and-pyrimidine-pathways-as-antimalarial-targets",totalDownloads:0,totalCrossrefCites:null,totalDimensionsCites:null,authors:null,book:{title:"Malaria - Recent Advances, and New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"83065",title:"Interventions and Practical Approaches to Reduce the Burden of Malaria on School-Aged Children",doi:"10.5772/intechopen.106469",signatures:"Andrew Macnab",slug:"interventions-and-practical-approaches-to-reduce-the-burden-of-malaria-on-school-aged-children",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Andrew",surname:"Macnab"}],book:{title:"Malaria - Recent Advances, and New Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11576.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82804",title:"Psychiatric Problems in HIV Care",doi:"10.5772/intechopen.106077",signatures:"Seggane Musisi and Noeline Nakasujja",slug:"psychiatric-problems-in-hiv-care",totalDownloads:2,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82827",title:"Epidemiology and Control of Schistosomiasis",doi:"10.5772/intechopen.105170",signatures:"Célestin Kyambikwa Bisangamo",slug:"epidemiology-and-control-of-schistosomiasis",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"New Horizons for Schistosomiasis Research",coverURL:"https://cdn.intechopen.com/books/images_new/10829.jpg",subseries:{id:"5",title:"Parasitic Infectious Diseases"}}},{id:"82817",title:"Perspective Chapter: Microfluidic Technologies for On-Site Detection and Quantification of Infectious Diseases - The Experience with SARS-CoV-2/COVID-19",doi:"10.5772/intechopen.105950",signatures:"Andres Escobar and Chang-qing Xu",slug:"perspective-chapter-microfluidic-technologies-for-on-site-detection-and-quantification-of-infectious",totalDownloads:3,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82667",title:"Perspective Chapter: Analysis of SARS-CoV-2 Indirect Spreading Routes and Possible Countermeasures",doi:"10.5772/intechopen.105914",signatures:"Cesare Saccani, Marco Pellegrini and Alessandro Guzzini",slug:"perspective-chapter-analysis-of-sars-cov-2-indirect-spreading-routes-and-possible-countermeasures",totalDownloads:10,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82559",title:"Perspective Chapter: Bioinformatics Study of the Evolution of SARS-CoV-2 Spike Protein",doi:"10.5772/intechopen.105915",signatures:"Črtomir Podlipnik, Radostina Alexandrova, Sebastian Pleško, Urban Bren and Marko Jukič",slug:"perspective-chapter-bioinformatics-study-of-the-evolution-of-sars-cov-2-spike-protein",totalDownloads:14,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82521",title:"Challenges in Platelet Functions in HIV/AIDS Management",doi:"10.5772/intechopen.105731",signatures:"Gordon Ogweno",slug:"challenges-in-platelet-functions-in-hiv-aids-management",totalDownloads:16,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Future Opportunities and Tools for Emerging Challenges for HIV/AIDS Control",coverURL:"https://cdn.intechopen.com/books/images_new/11575.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}},{id:"82701",title:"Pathology of Streptococcal Infections",doi:"10.5772/intechopen.105814",signatures:"Yutaka Tsutsumi",slug:"pathology-of-streptococcal-infections",totalDownloads:8,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Yutaka",surname:"Tsutsumi"}],book:{title:"Streptococcal Infections",coverURL:"https://cdn.intechopen.com/books/images_new/10828.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}},{id:"82634",title:"Bacterial Sexually Transmitted Disease",doi:"10.5772/intechopen.105747",signatures:"Lebeza Alemu Tenaw",slug:"bacterial-sexually-transmitted-disease",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Bacterial Sexually Transmitted Infections - New Findings, Diagnosis, Treatment, and Prevention",coverURL:"https://cdn.intechopen.com/books/images_new/11569.jpg",subseries:{id:"3",title:"Bacterial Infectious Diseases"}}}]},subseriesFiltersForOFChapters:[{caption:"Fungal Infectious Diseases",value:4,count:1,group:"subseries"},{caption:"Bacterial Infectious Diseases",value:3,count:5,group:"subseries"},{caption:"Parasitic Infectious Diseases",value:5,count:5,group:"subseries"},{caption:"Viral Infectious Diseases",value:6,count:10,group:"subseries"}],publishedBooks:{paginationCount:9,paginationItems:[{type:"book",id:"10654",title:"Brain-Computer Interface",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/10654.jpg",slug:"brain-computer-interface",publishedDate:"May 18th 2022",editedByType:"Edited by",bookSignature:"Vahid Asadpour",hash:"a5308884068cc53ed31c6baba756857f",volumeInSeries:9,fullTitle:"Brain-Computer Interface",editors:[{id:"165328",title:"Dr.",name:"Vahid",middleName:null,surname:"Asadpour",slug:"vahid-asadpour",fullName:"Vahid Asadpour",profilePictureURL:"https://mts.intechopen.com/storage/users/165328/images/system/165328.jpg",institutionString:"Kaiser Permanente Southern California",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10859",title:"Data Mining",subtitle:"Concepts and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10859.jpg",slug:"data-mining-concepts-and-applications",publishedDate:"March 30th 2022",editedByType:"Edited by",bookSignature:"Ciza Thomas",hash:"63a4e514e537d3962cf53ef1c6b9d5eb",volumeInSeries:8,fullTitle:"Data Mining - Concepts and Applications",editors:[{id:"43680",title:"Prof.",name:"Ciza",middleName:null,surname:"Thomas",slug:"ciza-thomas",fullName:"Ciza Thomas",profilePictureURL:"https://mts.intechopen.com/storage/users/43680/images/system/43680.jpeg",institutionString:null,institution:{name:"Government of Kerala",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"10651",title:"Machine Learning",subtitle:"Algorithms, Models and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/10651.jpg",slug:"machine-learning-algorithms-models-and-applications",publishedDate:"December 22nd 2021",editedByType:"Edited by",bookSignature:"Jaydip Sen",hash:"6208156401c496e0a4ca5ff4265324cc",volumeInSeries:7,fullTitle:"Machine Learning - Algorithms, Models and Applications",editors:[{id:"4519",title:"Prof.",name:"Jaydip",middleName:null,surname:"Sen",slug:"jaydip-sen",fullName:"Jaydip Sen",profilePictureURL:"https://mts.intechopen.com/storage/users/4519/images/system/4519.jpeg",institutionString:"Praxis Business School",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9869",title:"Self-Driving Vehicles and Enabling Technologies",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9869.jpg",slug:"self-driving-vehicles-and-enabling-technologies",publishedDate:"September 22nd 2021",editedByType:"Edited by",bookSignature:"Marian Găiceanu",hash:"fd451ca2e4785ef098e04b7d695a18d9",volumeInSeries:6,fullTitle:"Self-Driving Vehicles and Enabling Technologies",editors:[{id:"169608",title:"Prof.",name:"Marian",middleName:null,surname:"Găiceanu",slug:"marian-gaiceanu",fullName:"Marian Găiceanu",profilePictureURL:"https://mts.intechopen.com/storage/users/169608/images/system/169608.png",institutionString:'"Dunarea de Jos" University of Galati',institution:{name:'"Dunarea de Jos" University of Galati',institutionURL:null,country:{name:"Romania"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9958",title:"Artificial Intelligence",subtitle:"Latest Advances, New Paradigms and Novel Applications",coverURL:"https://cdn.intechopen.com/books/images_new/9958.jpg",slug:"artificial-intelligence-latest-advances-new-paradigms-and-novel-applications",publishedDate:"September 1st 2021",editedByType:"Edited by",bookSignature:"Eneko Osaba, Esther Villar, Jesús L. Lobo and Ibai Laña",hash:"39648fbfdaa11385097d62b1f13aad54",volumeInSeries:5,fullTitle:"Artificial Intelligence - Latest Advances, New Paradigms and Novel Applications",editors:[{id:"221364",title:"Dr.",name:"Eneko",middleName:null,surname:"Osaba",slug:"eneko-osaba",fullName:"Eneko Osaba",profilePictureURL:"https://mts.intechopen.com/storage/users/221364/images/system/221364.jpg",institutionString:"TECNALIA Research & Innovation",institution:{name:"Tecnalia",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"9963",title:"Advances and Applications in Deep Learning",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9963.jpg",slug:"advances-and-applications-in-deep-learning",publishedDate:"December 9th 2020",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"0d51ba46f22e55cb89140f60d86a071e",volumeInSeries:4,fullTitle:"Advances and Applications in Deep Learning",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7656",title:"Fuzzy Logic",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7656.jpg",slug:"fuzzy-logic",publishedDate:"February 5th 2020",editedByType:"Edited by",bookSignature:"Constantin Volosencu",hash:"54f092d4ffe0abf5e4172a80025019bc",volumeInSeries:3,fullTitle:"Fuzzy Logic",editors:[{id:"1063",title:"Prof.",name:"Constantin",middleName:null,surname:"Volosencu",slug:"constantin-volosencu",fullName:"Constantin Volosencu",profilePictureURL:"https://mts.intechopen.com/storage/users/1063/images/system/1063.png",institutionString:'"Politechnica" University Timişoara',institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7726",title:"Swarm Intelligence",subtitle:"Recent Advances, New Perspectives and Applications",coverURL:"https://cdn.intechopen.com/books/images_new/7726.jpg",slug:"swarm-intelligence-recent-advances-new-perspectives-and-applications",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Javier Del Ser, Esther Villar and Eneko Osaba",hash:"e7ea7e74ce7a7a8e5359629e07c68d31",volumeInSeries:2,fullTitle:"Swarm Intelligence - Recent Advances, New Perspectives and Applications",editors:[{id:"49813",title:"Dr.",name:"Javier",middleName:null,surname:"Del Ser",slug:"javier-del-ser",fullName:"Javier Del Ser",profilePictureURL:"https://mts.intechopen.com/storage/users/49813/images/system/49813.png",institutionString:"Tecnalia Research & Innovation",institution:{name:"Tecnalia",institutionURL:null,country:{name:"Spain"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7723",title:"Artificial Intelligence",subtitle:"Applications in Medicine and Biology",coverURL:"https://cdn.intechopen.com/books/images_new/7723.jpg",slug:"artificial-intelligence-applications-in-medicine-and-biology",publishedDate:"July 31st 2019",editedByType:"Edited by",bookSignature:"Marco Antonio Aceves-Fernandez",hash:"a3852659e727f95c98c740ed98146011",volumeInSeries:1,fullTitle:"Artificial Intelligence - Applications in Medicine and Biology",editors:[{id:"24555",title:"Dr.",name:"Marco Antonio",middleName:null,surname:"Aceves Fernandez",slug:"marco-antonio-aceves-fernandez",fullName:"Marco Antonio Aceves Fernandez",profilePictureURL:"https://mts.intechopen.com/storage/users/24555/images/system/24555.jpg",institutionString:"Universidad Autonoma de Queretaro",institution:{name:"Autonomous University of Queretaro",institutionURL:null,country:{name:"Mexico"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Computational Neuroscience",value:23,count:1},{group:"subseries",caption:"Evolutionary Computation",value:25,count:1},{group:"subseries",caption:"Machine Learning and Data Mining",value:26,count:3},{group:"subseries",caption:"Applied Intelligence",value:22,count:4}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:3},{group:"publicationYear",caption:"2020",value:2020,count:2},{group:"publicationYear",caption:"2019",value:2019,count:2}],authors:{paginationCount:754,paginationItems:[{id:"310674",title:"Dr.",name:"Pravin",middleName:null,surname:"Kendrekar",slug:"pravin-kendrekar",fullName:"Pravin Kendrekar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310674/images/system/310674.jpg",biography:"Dr. Pravin Kendrekar, MSc, MBA, Ph.D., is currently a visiting scientist at the Lipid Nanostructure Laboratory, University of Central Lancashire, England. He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"10",type:"subseries",title:"Animal Physiology",keywords:"Physiology, Comparative, Evolution, Biomolecules, Organ, Homeostasis, Anatomy, Pathology, Medical, Cell Division, Cell Signaling, Cell Growth, Cell Metabolism, Endocrine, Neuroscience, Cardiovascular, Development, Aging, Development",scope:"Physiology, the scientific study of functions and mechanisms of living systems, is an essential area of research in its own right, but also in relation to medicine and health sciences. The scope of this topic will range from molecular, biochemical, cellular, and physiological processes in all animal species. Work pertaining to the whole organism, organ systems, individual organs and tissues, cells, and biomolecules will be included. Medical, animal, cell, and comparative physiology and allied fields such as anatomy, histology, and pathology with physiology links will be covered in this topic. Physiology research may be linked to development, aging, environment, regular and pathological processes, adaptation and evolution, exercise, or several other factors affecting, or involved with, animal physiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/10.jpg",hasOnlineFirst:!1,hasPublishedBooks:!1,annualVolume:11406,editor:{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"306970",title:"Mr.",name:"Amin",middleName:null,surname:"Tamadon",slug:"amin-tamadon",fullName:"Amin Tamadon",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002oHR5wQAG/Profile_Picture_1623910304139",institutionString:null,institution:{name:"Bushehr University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",institutionURL:null,country:{name:"Spain"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",institutionString:null,institution:{name:"Alexandria University",institutionURL:null,country:{name:"Egypt"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",institutionString:"Kafkas University",institution:{name:"Kafkas University",institutionURL:null,country:{name:"Turkey"}}}]},onlineFirstChapters:{paginationCount:26,paginationItems:[{id:"83087",title:"Role of Cellular Responses in Periodontal Tissue Destruction",doi:"10.5772/intechopen.106645",signatures:"Nam Cong-Nhat Huynh",slug:"role-of-cellular-responses-in-periodontal-tissue-destruction",totalDownloads:1,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Periodontology - New Insights",coverURL:"https://cdn.intechopen.com/books/images_new/11566.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82654",title:"Atraumatic Restorative Treatment: More than a Minimally Invasive Approach?",doi:"10.5772/intechopen.105623",signatures:"Manal A. Ablal",slug:"atraumatic-restorative-treatment-more-than-a-minimally-invasive-approach",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82735",title:"The Influence of Salivary pH on the Prevalence of Dental Caries",doi:"10.5772/intechopen.106154",signatures:"Laura-Cristina Rusu, Alexandra Roi, Ciprian-Ioan Roi, Codruta Victoria Tigmeanu and Lavinia Cosmina Ardelean",slug:"the-influence-of-salivary-ph-on-the-prevalence-of-dental-caries",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"82357",title:"Caries Management Aided by Fluorescence-Based Devices",doi:"10.5772/intechopen.105567",signatures:"Atena Galuscan, Daniela Jumanca and Aurora Doris Fratila",slug:"caries-management-aided-by-fluorescence-based-devices",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"81894",title:"Diet and Nutrition and Their Relationship with Early Childhood Dental Caries",doi:"10.5772/intechopen.105123",signatures:"Luanna Gonçalves Ferreira, Giuliana de Campos Chaves Lamarque and Francisco Wanderley Garcia Paula-Silva",slug:"diet-and-nutrition-and-their-relationship-with-early-childhood-dental-caries",totalDownloads:20,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Dental Caries - The Selection of Restoration Methods and Restorative Materials",coverURL:"https://cdn.intechopen.com/books/images_new/11565.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80964",title:"Upper Airway Expansion in Disabled Children",doi:"10.5772/intechopen.102830",signatures:"David Andrade, Joana Andrade, Maria-João Palha, Cristina Areias, Paula Macedo, Ana Norton, Miguel Palha, Lurdes Morais, Dóris Rocha Ruiz and Sônia Groisman",slug:"upper-airway-expansion-in-disabled-children",totalDownloads:44,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80839",title:"Herbs and Oral Health",doi:"10.5772/intechopen.103715",signatures:"Zuhair S. Natto",slug:"herbs-and-oral-health",totalDownloads:70,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80441",title:"Periodontitis and Heart Disease: Current Perspectives on the Associative Relationships and Preventive Impact",doi:"10.5772/intechopen.102669",signatures:"Alexandra Roman, Andrada Soancă, Bogdan Caloian, Alexandru Bucur, Gabriela Valentina Caracostea, Andreia Paraschiva Preda, Dora Maria Popescu, Iulia Cristina Micu, Petra Șurlin, Andreea Ciurea, Diana Oneț, Mircea Viorel Ciurea, Dragoș Alexandru Țermure and Marius Negucioiu",slug:"periodontitis-and-heart-disease-current-perspectives-on-the-associative-relationships-and-preventive",totalDownloads:66,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79498",title:"Oral Aspects and Dental Management of Special Needs Patient",doi:"10.5772/intechopen.101067",signatures:"Pinar Kiymet Karataban",slug:"oral-aspects-and-dental-management-of-special-needs-patient",totalDownloads:114,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Pinar",surname:"Karataban"}],book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79699",title:"Metabolomics Distinction of Cigarette Smokers from Non-Smokers Using Non-Stationary Benchtop Nuclear Magnetic Resonance (NMR) Analysis of Human Saliva",doi:"10.5772/intechopen.101414",signatures:"Benita C. Percival, Angela Wann, Sophie Taylor, Mark Edgar, Miles Gibson and Martin Grootveld",slug:"metabolomics-distinction-of-cigarette-smokers-from-non-smokers-using-non-stationary-benchtop-nuclear",totalDownloads:56,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80295",title:"Preventive Methods and Treatments of White Spot Lesions in Orthodontics",doi:"10.5772/intechopen.102064",signatures:"Elif Nadide Akay",slug:"preventive-methods-and-treatments-of-white-spot-lesions-in-orthodontics",totalDownloads:89,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79876",title:"Management and Prevention Strategies for Treating Dentine Hypersensitivity",doi:"10.5772/intechopen.101495",signatures:"David G. Gillam",slug:"management-and-prevention-strategies-for-treating-dentine-hypersensitivity",totalDownloads:94,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"80020",title:"Alternative Denture Base Materials for Allergic Patients",doi:"10.5772/intechopen.101956",signatures:"Lavinia Cosmina Ardelean, Laura-Cristina Rusu and Codruta Victoria Tigmeanu",slug:"alternative-denture-base-materials-for-allergic-patients",totalDownloads:198,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79297",title:"Oral Health and Prevention in Older Adults",doi:"10.5772/intechopen.101043",signatures:"Irma Fabiola Díaz-García, Dinorah Munira Hernández-Santos, Julio Alberto Díaz-Ramos and Neyda Ma. Mendoza-Ruvalcaba",slug:"oral-health-and-prevention-in-older-adults",totalDownloads:113,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79903",title:"Molecular Docking of Phytochemicals against Streptococcus mutans Virulence Targets: A Proteomic Insight into Drug Planning",doi:"10.5772/intechopen.101506",signatures:"Diego Romário da Silva, Tahyná Duda Deps, Otavio Akira Souza Sakaguchi, Edja Maria Melo de Brito Costa, Carlus Alberto Oliveira dos Santos, Joanilda Paolla Raimundo e Silva, Bruna Dantas da Silva, Frederico Favaro Ribeiro, Francisco Jaime Bezerra Mendonça-Júnior and Andréa Cristina Barbosa da Silva",slug:"molecular-docking-of-phytochemicals-against-em-streptococcus-mutans-em-virulence-targets-a-proteomic",totalDownloads:114,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}},{id:"79754",title:"Evaluation of Trans-Resveratrol as a Treatment for Periodontitis",doi:"10.5772/intechopen.101477",signatures:"Tracey Lynn Harney",slug:"evaluation-of-trans-resveratrol-as-a-treatment-for-periodontitis",totalDownloads:112,totalCrossrefCites:1,totalDimensionsCites:1,authors:null,book:{title:"Oral Health Care - An Important Issue of the Modern Society",coverURL:"https://cdn.intechopen.com/books/images_new/10827.jpg",subseries:{id:"1",title:"Oral Health"}}}]},publishedBooks:{paginationCount:4,paginationItems:[{type:"book",id:"9528",title:"Current Topics and Emerging Issues in Malaria Elimination",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/9528.jpg",slug:"current-topics-and-emerging-issues-in-malaria-elimination",publishedDate:"July 21st 2021",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"7f178329cc42e691efe226b32f14e2ea",volumeInSeries:8,fullTitle:"Current Topics and Emerging Issues in Malaria Elimination",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7981",title:"Overview on Echinococcosis",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7981.jpg",slug:"overview-on-echinococcosis",publishedDate:"April 22nd 2020",editedByType:"Edited by",bookSignature:"Fethi Derbel and Meriem Braiki",hash:"24dee9209f3fd6b7cd28f042da0076f0",volumeInSeries:6,fullTitle:"Overview on Echinococcosis",editors:[{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",institutionString:"Clinique les Oliviers",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7839",title:"Malaria",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7839.jpg",slug:"malaria",publishedDate:"December 11th 2019",editedByType:"Edited by",bookSignature:"Fyson H. Kasenga",hash:"91cde4582ead884cb0f355a19b67cd56",volumeInSeries:4,fullTitle:"Malaria",editors:[{id:"86725",title:"Dr.",name:"Fyson",middleName:"Hanania",surname:"Kasenga",slug:"fyson-kasenga",fullName:"Fyson Kasenga",profilePictureURL:"https://mts.intechopen.com/storage/users/86725/images/system/86725.jpg",institutionString:"Malawi Adventist University",institution:{name:"Malawi Adventist University",institutionURL:null,country:{name:"Malawi"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null},{type:"book",id:"7123",title:"Current Topics in Neglected Tropical Diseases",subtitle:null,coverURL:"https://cdn.intechopen.com/books/images_new/7123.jpg",slug:"current-topics-in-neglected-tropical-diseases",publishedDate:"December 4th 2019",editedByType:"Edited by",bookSignature:"Alfonso J. Rodriguez-Morales",hash:"61c627da05b2ace83056d11357bdf361",volumeInSeries:3,fullTitle:"Current Topics in Neglected Tropical Diseases",editors:[{id:"131400",title:"Prof.",name:"Alfonso J.",middleName:null,surname:"Rodriguez-Morales",slug:"alfonso-j.-rodriguez-morales",fullName:"Alfonso J. Rodriguez-Morales",profilePictureURL:"https://mts.intechopen.com/storage/users/131400/images/system/131400.png",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},testimonialsList:[{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:141,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:11,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/30812",hash:"",query:{},params:{id:"30812"},fullPath:"/chapters/30812",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()