IFT Terminologies from the Yahoo! Pipes Perspective [2].
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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
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In modern times, mass communication, mass media, and networking technologies have enabled access to vast amounts of knowledge that are distributed across many continents and time-zones, thus allowing web-active end-users to achieve great feats.
Web-active end-users (also referred to as end-users or end-user programmers) are people who lack programming experience but are engaged in internet activities [1]. There is a substantial number of web-active end-users and their number is continuously growing. The end-users often create applications to complete tasks such as finding apartments to rent in a certain location, tracking flights, and alerting drivers regarding traffic jams. One approach to create such applications is utilizing web mashups programming environments.
Web mashup programming environments allow for creating applications from distributed heterogeneous web sources and functions. Most of the mashup programming environments are visual in nature. Some examples include Yahoo! Pipes [2], IBM mashup maker [3], xfruit [4], Apatar [5], Deri pipes [6], and JackBe [7]. The visual nature of these programming environments allows application creation using code abstraction to ease the programming process. However, the abstraction of code can add complexity of accessing the information, debugging, and comprehending large programs within these environments [1, 8, 9].
Further, end-users create mashup applications by seeking information from the complex ecosystem of the web, which is composed of evolving heterogeneous formats, services, standards, and languages [8]. Seeking information on the web is challenging, as the relevant information is scattered across numerous web sources that end-users must find and manually analyze, an information-seeking problem that costs both time and cognitive effort.
In this chapter, we observe the behavior of end-users while debugging, one of the most difficult aspects of programming [10]. Debugging mashup programs is even more challenging as end-user programmers must locate bugs within the abstract web mashup environment and then locate solutions on the web to fix bugs. The lack of debugging support within mashup environments increases the complexity of finding bugs [9]. Further, finding correct solutions to fix bugs is complicated as the web is a huge compilation of heterogeneous resources.
Currently, it is not clear how web-active end-users seek for bugs in their program and their solutions on the web. Hence, we used an information seeking theory called Information Foraging Theory.
Information Foraging Theory (IFT) can expand our understanding of the information-seeking problems of web-active end-user programmers while debugging. IFT posits that people seek information in the same manner as predators forage for their prey, where predators are the end-users, and the prey is the bugs or bug fixes they are searching for. The hunting grounds or ‘patches’ where web-active end-users search for these bugs or fixes would be their IDE or the websites they visit and the scents the web-active end-users follow are given by different cues (e.g., links) found on the web [11, 12, 13, 14, 15]. IFT has been applied successfully to diverse domains such as documents, the web, user interfaces, and programming environments [15, 16, 17, 18, 19, 20, 21, 22, 23].
Past research on web mashups have focused on creating web tools that increase the ease and effectiveness of creating applications by end-user programmers [24, 25, 26, 27, 28]. While past IFT research on programming environments has investigated debugging and navigational behavior of professional programmers [19, 20, 21]. No prior research exists to understand the debugging behavior of web-active end-user programmers. The only research relevant to this chapter is our own [8], where we created a debugging support for web mashups and investigated the debugging behavior of end-user programmers using IFT with and without the support. Based on this prior research, we found IFT to be the most relevant choice to understand the information-seeking behavior during mashup debugging.
To understand the debugging behavior of end-user programmers we conducted a controlled lab study of eight students who were not computer science majors. The study participants completed their tasks using Yahoo! Pipes, a mashup environment, as it provided the best debugging support at the time. The participants completed two debugging tasks using a think-aloud protocol. We investigated how end-users forage for information within the IDE as well as the web using IFT theory. Our analyses discovered new cues and strategies that end-user programmers pursued while locating the bugs in the mashup environment and foraging the web for fixing the bugs.
This chapter is organized as follows. Section 2 describes the debugging behavior of end-user programmers. Section 3 describes Information Foraging Theory, IFT terminologies from Yahoo! Pipes, and relevant literature. Section 4 describes the background and related work on web mashups, and Yahoo! Pipes. Section 5 describes the methodology and results from the lab study. This section discusses the cues utilized by end-user programmers and their behavior during debugging tasks and provides recommendations. Section 6 summarizes our findings and suggests how web mashup environments can improve the debugging process.
Debugging is the process of finding and fixing bugs in the code. Programmers often struggle to debug and hypothesize the “when”, “why” and “how” of the bug [29, 30, 31, 32]. Debugging is even more challenging for end-user programmers as in one study [33] they spent two-thirds of their time foraging for bugs, while professionals spent only half of their time.
Professionals and end-users use web resources to complete their programming tasks. For example, in one study, novice programmers spent about 19% of their programming time in foraging the web for information such as selecting and using tutorials, searching with synonyms, finding code snippets, and using the web to debug [34], while they spent 35% of their time navigating source code [35]. Vessey [36] investigated both professionals and end-users’ debugging approach and found that professionals took a breadth-first approach whereas end-users took a depth-first approach. Our study found that in mashup environments the end user programmers struggle foraging for solutions to bugs on the web.
A major huddle for programmers during debugging is understanding the error messages to fix bugs in the code. Naveed and Sarim [37] analyzed how presentation of error messages affected debugging and programming in IDEs. To fix a bug, first programmers must understand what the error is and where it is located. Mashup environments tend to show errors without much explanation or direction for the end-user to comprehend [9]. End-users struggle to adapt code from tutorials and web forums [38] while fixing bugs. They often struggle with debugging due to lack of knowledge and experience in software engineering and interactive programming environments [39]. Our study confirms that end-user programmers struggle with the lack of or unclear error messages in IDEs.
Understanding end-user programmers’ behavior while debugging can help to build better debugging tools that facilitates programming tasks effectively and efficiently. Phalgune et al. [40] studied oracle mistakes - mistakes users make about which values are right and which are wrong - that impact the effectiveness of interactions, testing, and debugging support for end-users. Kuttal et al. [41] added version support to Yahoo! Pipes and investigated how versioning can help end-user programmers to create and debug mashups. Servant et al. [42] create support that allowed panning and zooming of a canvas that contained the snapshots of the code. Myers and Ko suggested various interaction features for IDE to improve debugging such as full visibility of code and timeline visualization of changing values of variables at run-time [43]. Our study helps to understand how end-user programmers debug from a theory perspective that can inform better debugging support for mashup environments.
Web mashups allow end-users to build applications by integrating data and functionalities from various web services into a single application. The visual web mashup programming environments facilitate easy creation of applications by end-user programmers who have very little knowledge and experience in programming. Mashup environments provide a full set of functions to the end-users to build new applications.
End-users often create situational mashups as per their specifications [44]. For example, a mashup can take data from Instagram and combine it with Google Maps to display the most recent images and videos of any given location. Users can get the data from APIs, Information Feeds (e.g., Really Simple Syndication (RSS)), or they can collect data by scraping various web pages. Mashup application can be executed within the client’s browser, in a server, or combination of both. The advantage of rendering the application in a client’s web browser is to give users the opportunity to interact with it. Mashups are popular because of their dynamic content creation and ability to build and share applications through publicly hosted repositories [45].
End-users often develop mashup applications using visual black-box oriented programming environments. Mashup programming environments such as Yahoo! Pipes [2], IBM mashup maker [3], xfruit [4], Apatar [5], Deri Pipes [6], and JackBe [7] provide an easy-to-use visual environment to support the mashup development. Cappiello at el. [46] researched mashup development frameworks oriented towards end-user development to allow users to compose different resources at different levels of granularity relying on the user interface (UI) of the application. Ennals and Gay created MashMaker [24], a tool which allowed end-users to create web mashups without needing to write much code/script. Other mashup creation tools to facilitate end user programmers include MapCruncher [25], Marmite [26], Automator [27], Creo [28], and TreeSheet [47]. Rather than directly studying mashup environments or creating new mashup tools, we qualitatively observe how end-users debug and forage for solutions in programs built in these mashups.
Grammel and Storey [9] investigated various mashup development environments and found lack of debugging support in these environments. Similarly, Stolee and Elbaum [48] studied how we can improve the refactoring of pipe-like mashups, i.e., Yahoo! Pipes for end-users. We focus on understanding end-user programmers’ behavior while debugging mashups instead of creating support for mashups.
Now defunct, Yahoo! Pipes was introduced in 2007 and was one of the most popular mashup creation environments that helped users to “rewrite the web” during its existence. During its first year of existence, the Yahoo! Pipes platform executed over 5,000,000 pipes per day. As a visual programming environment, Yahoo! Pipes was well suited for representing the solutions to dataflow-based processing problems. Yahoo! Pipes “programs” helped in combining simple commands together such that the output of one acted as the input for the other. The Yahoo! Pipes engine also facilitated the wiring of modules together and the transfer of data between them.
The Yahoo! Pipes environment was made up of three major components: the canvas, the library (list of modules), and the debugger (refer Figure 1). Users used the canvas to create the pipes. The library situated to the left of the canvas, consisted of various modules that were categorized according to functionality. Users dragged modules from the library and placed them on the canvas, then proceeded to connect them to other modules as their need. The debugger, located at the bottom, helped users check the runtime output of the modules.
Yahoo! Pipes.
The inputs and output of the pipes supported different formats. For input, most common formats were APIs, HTML, XML, JSON, RDF, and RSS feeds. Similarly, pipe output formats were RSS, JSON, and KML. The inputs and outputs between modules were primarily RSS feed items consisting of parameters and descriptions. Yahoo! Pipes modules provided manipulation actions that could be executed on these RSS feed parameters. In addition to items, Yahoo! Pipes also allowed datatypes like URL, location, text, number, and date-time to be defined by users.
Figure 1 shows the interface and components of the Yahoo! Pipes environment. The pipe displayed in the figure takes Reuter’s Newsfeed (RSS feed) as input using a Fetch Feed module which is then filtered (using a Filter module) based on users’ input (sports). These results are converted from English to Greek using a Translate module inside a Loop module. The pipe titles are limited to the first seven results using the truncate module. In Figure 1, the debugger window displays the runtime output from the Fetch Feed module.
Yahoo! Pipes allowed the creation and rendering of the pipes on the client side while the executing and storing of the pipe was done on the Yahoo! Servers. The data between the client and server was transfer using JSON format. Yahoo! Pipes allowed end-users to share their pipe (code) as well as reuse other user’s pipes by cloning.
Stolee et al. [49] analyzed 32,000 mashups from Yahoo! Pipes repositories based on popularity, configurability, complexity, and diversity. Wang and Wang [50] used Yahoo! Pipes to build a mobile news aggregator application. We used Yahoo! Pipes for this study as it had the best debugging support at the time of the research.
Information Foraging Theory (IFT) was developed by Pirolli and Card [11] to understand how people search for information. IFT was inspired by optimal foraging theory, which is a biological theory explaining how predators hunt for their prey in the wild. Optimal foraging theory predicts whether a prey (animal) will try to maximize the energy it gains or minimize the expense to obtain a fixed amount of energy [12]. Similarly, while foraging for information, users must realize their maximum return on information gain at minimum expenditure of their time. Therefore, users, when possible, will modify their strategies to maximize their rate of gaining valuable information [13]. Table 1 elaborates the IFT terminologies along with examples from Yahoo! Pipes.
IFT Terminologies | Definitions | Bug Finding (Examples) | Bug Fixing (Examples) |
---|---|---|---|
Prey | Bugs; solutions | Finding bug B2 (url does not lead to the right web site) in Fetch Feed module | Finding the correct url and putting it in the Fetch Feed module that contains B2 |
Information Patch | Localities in the code, documents, examples, web-pages and displays that may contain the prey [23] | Yahoo! Pipes Editor, help documents, help examples | Web pages |
Information Feature | Words, links, error messages, or highlighted objects that suggest scent relative to prey | API Key Missing error message “Error fetching [url]. Response: Not found (404)” for bug B1 | Finding the right API key from the website |
Cues | Proximal links to patches | “about this module” link to the example code related to specific module | “Key” link to the Flickr page to collect the API key |
Navigate | Navigation by users through patches | To find bug B2 the user navigated through Yahoo! Pipes editor to external web site | To correct bug B2 participant navigated to various web sites to find the required url |
IFT Terminologies from the Yahoo! Pipes Perspective [2].
IFT has helped to improve the understanding of the users’ behaviors and interactions on the web. In the very beginning, research was done for general Internet users, which led to the foundation of IFT [15, 18, 51]. Research has been done to observe and study foragers on the web [8, 15, 21, 51]. IFT has been used to improve the usability of web sites [52] as it has helped to explain and predict why people click a particular link, text, or button on a website [14]. In this research, we qualitatively analyze multiple end-user’s foraging behavior to find solutions for their bugs on the web.
IFT has also been used to understand software engineering and software development [8, 19, 20] along with its collaborative environments [17]. Piorkowski et al. have explored foraging behavior and the difference in foraging between desktop and mobile integrated development environment (IDE) [53]. Niu et al. used IFT to design navigation affordances in IDEs [54]. Similarly, IFT has been used to find out the optimal team size for open-source projects [55]. IFT can help to understand the foraging behavior of web-active end-user programmers when engaged in programming activities such as comprehension, reusage of code, implementation, debugging and testing. This research focuses on the debugging behavior of web-active end-user programmers.
Researchers have built computational models of user information foraging behavior when completing tasks [14, 56, 57]. These models have also helped in predicting the effects of social influences on IFT [58]. The researchers have developed the WUFIS model for the web [6] and the PFIS model for programmers foraging in IDEs [19, 20]. Ragavan et al. analyzed the novice programmers’ foraging in the presence of program variants [22] and built a predictive model [59] inspired by the PFIS model [23, 60]. Our focus is to understand the end-user foraging behavior before creating such computational models.
To understand how end-user programmers forage mashup IDEs (Yahoo! Pipes) for finding bugs and the web for finding solutions for the bugs, we conducted a controlled lab study.
Our study observed eight university students who had no background in computer science but had experience with one web language. The students were from diverse fields such as engineering, finance, mathematics, and natural sciences. The participants completed the background questionnaire, a short tutorial on Yahoo! Pipes, and a pilot task to practice programming with Yahoo! Pipes. Once the participants felt comfortable with the Yahoo! Pipes environment, they completed two tasks using the think-aloud method.
The participants were given Yahoo! Pipes programs that were seeded with bugs. The first task (Yahoo! Pipes Error) was a pipe program that was seeded with bugs detected by Yahoo! Pipes and displayed a relevant error message. The second task (Silent Error) was seeded with bugs that were not detected by Yahoo! Pipes and therefore did not display an error message. Further, both tasks contained two classes: top level and nested. Top level contained bugs that were easy to comprehend while the nested class contained sub-pipes with bugs. These sub-pipes needed to be opened in a separate IDE to be found. The details of the tasks can be found in Table 2.
Task | Class | Bugs | Details |
---|---|---|---|
Yahoo! Pipes Error | Top Level | B1 | API key missing |
B2 | Website not found | ||
Nested | B3 | Website not found | |
Silent Error | Top Level | B4 | Website contents changed |
B5 | Parameter missing | ||
Nested | B6 | Parameter missing |
Details on seeded bugs in the tasks [2].
Participants’ verbalization and actions were transcribed and analyzed using IFT theory. When analyzing the transcripts, we found various cues and strategies used by our participants.
In finding the bugs and their fixes, participants followed cues. Based on the strength of the cues, they can be classified as clear, fuzzy, and elusive.
Cues | Description | Example |
---|---|---|
Clear Cues | Cues that were clear and easy to understand | ‘ |
Fuzzy Cues | Cues that were difficult to understand | ‘ |
Elusive Cues | Cues that were difficult to find | This cue was shown when a fault was nested. |
Participants foraged Yahoo! Pipes IDE to find the bugs and the web to fix the bugs. Table 3 shows the number of bugs located and fixed by each participant. The results show that end user programmers struggled to debug their pipe programs. The key findings were:
Participants | Yahoo! Pipes | Silent Errors | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
B1 | B2 | B3 | B4 | B5 | B6 | |||||||
L | F | L | F | L | F | L | F | L | F | L | F | |
P1 | 1 | 1 | — | — | — | — | — | — | 1 | — | — | — |
P2 | 1 | 1 | 1 | — | — | — | — | — | — | — | — | — |
P3* | 1 | 1 | 1 | 1 | — | — | 1 | 1 | 1 | 1 | — | — |
P4 | 1 | 1 | 1 | — | — | — | 1 | — | 1 | 1 | — | — |
P5 | 1 | 1 | 1 | — | 1 | — | 1 | — | — | — | — | — |
P6 | 1 | 1 | 1 | — | 1 | 1 | 1 | — | 1 | — | 1 | — |
P7 | 1 | 1 | 1 | — | 1 | 1 | 1 | — | — | — | — | — |
P8 | 1 | — | 1 | — | — | — | 1 | — | — | — | — | — |
Total | 8 | 7 | 7 | 1 | 2 | 1 | 6 | 1 | 4 | 2 | 1 | 0 |
Bugs Finding and Fixed per Control Group Participant [2].
represents a participant with prior knowledge of Yahoo! Pipes.
The Yahoo! Errors B1 and B2 were easily located by the participants (refer Table 3). Yahoo! errors supported clear cues as these bugs had detailed error messages from Yahoo! Pipes. As discussed before, the Yahoo! Pipes environment provides little support for debugging i.e., just observing the output in the debugger window, hence silent errors B4 and B5 were harder for participants to locate and fix. Hence, end-users’ programming IDE should support clear cues i.e., displaying and visualizing of the error messages for the programmers.
Locating bugs was easier, especially in the presence of clear cues as well as when participants foraged in the restricted single patch of Yahoo! IDE to locate bugs. But when participants had to fix the bugs, they spent a tremendous amount of time foraging through different web pages (multiple patches). Participants used an enrichment strategy of searching on the web to find the valuable patches. But the quality of their search results depended upon the relevance of keywords. Hence, explicitly stating or automating support of the diet constraints (keywords related to bugs) in the search engines can increase the relevance of the results.
The nested bugs were the hardest to locate by the participants as they were elusive. In the case of bug B3, three participants were able to find them as they were
Participants foraged for finding the bugs using
These strategies reflect how the participants hunted for their prey (bugs). The participants had salient goals and they chose cues based on their prominence. For example, they looked for cues in the output of the pipe program. Most participants pursued the first available cue in the output. This explains why most participants pursued bug B1 and B4 (Table 3). The participants were mostly unsuccessful in finding the majority of bugs as participants were persistent and pursued a single bug until they found a fault (depth-first search). The hunting strategies were prompted by the environment itself. Hence, designing environments that facilitate problem solving strategies (such as “sleep on the problem”) and make prey more visible can facilitate effective hunting strategies by end-user programmers.
To make prey (bugs) more visible as well as to understand the patch, the participants used various enrichment strategies. They realigned/regrouped the modules so that the connections between them were more visible. For exploring the cues, they kept two patches side-by-side. For example, participants placed the editor and documentation side-by-side for better view of each window. This suggests that IDEs should allow multi-context views allowing end user programmers to view different dimensions of code and allow easy manipulation of the environment.
The participants carved out regions based on the data flow structure of Yahoo! Pipes and foraged for cues down each path separately. Whenever they found a weak scent (perceived value), they backtracked and returned to the previous cue or patch. Participants often needed to backtrack for small changes, and this suggests supporting fine-grained backtracking that allows non-linear explorations of past programming history [8, 41].
While fixing the bug, participants used
Participants searched for all possible cues that led them to fixes for the bugs and aggregated them. Most participants used Google to find the solution for bug fixes. They temporarily collected information to reduce cognitive efforts. For example, participants copied original URLs into the notepad and then started making changes to the pipe programs. Hence, supporting to-do lists can help end-user programmers to complete their tasks systematically [61]. Participants also kept the documents (web document and IDE) open side-by-side like when they searched for bugs, necessitating support for multi-contextual views for code and relevant web pages.
The participants skimmed through patches for stronger scents. They used already visited patches as negative evidence in their foraging pursuits. For example, participants closed the web pages immediately when they realized they had already visited them. This prompted the participants to backtrack often to previous cues or patches as they were no longer foraging in the right directions. This suggests the need of tools that allow backtracking across multiple patches.
After fixing the bugs, participants verified it by rerunning the pipe programs and comparing the output to the given solution (oracle). Verification is a very important step in software engineering and building automated techniques to support verification for end-user programmers can help them produce better quality software applications.
Our analysis of the debugging behavior of eight end-user participants using information foraging theory suggests that clear cues were the most cost-effective method for finding bugs in mashup environments. Clear cues created stronger perceived value and helped more in the debugging process allowing end-user programmers to locate bugs more easily when compared to fuzzy or elusive cues. Fuzzy and elusive cues resulted in a hindered debugging progress as end-users would end up in useless patches. In addition, the presence of sub-pipes added additional complexity to the debugging process as participants were unsure where cues were coming from, even if they were clear. Our study also examined how the participants followed the cues to find solutions to the present bugs.
The participants used three main strategies to locate bugs: hunting, navigation, and enrichment. While hunting they used a depth-first strategy resulting in a persistent pursuit of a single bug. When navigating the participants would use the dataflow structure of the program to perceive the value of the bug’s location and would backtrack through relevant program histories to locate the bug. Finally, when using the enrichment strategy, participants would organize their environment by placing their IDE side by side with a web browser or by rearranging the code for easier foraging.
The presence of relevant error messages made these strategies for finding bugs more effective; however, when fixing the bugs by foraging the web different strategies were needed in the absence of clear cues. The participants made use of enrichment, navigation, and verification strategies for fixing bugs. They enriched their patches by finding relevant information through Google, storing URLs of useful websites, and by having these resources open side by side next to the editor. The participants navigated the web and used negative evidence to avoid already visited webpages or unhelpful resources. Then by running the program after implementing fixes, the participants would verify that their solutions fixed the bugs.
Our results suggest mashup programming environments need to facilitate clear clues and support hunting, enrichment, navigational, and verification strategies to facilitate the debugging process for end-user programmers.
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Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/25351",hash:"",query:{},params:{id:"25351"},fullPath:"/chapters/25351",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()