\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"9415",leadTitle:null,fullTitle:"Advanced Oxidation Processes - Applications, Trends, and Prospects",title:"Advanced Oxidation Processes",subtitle:"Applications, Trends, and Prospects",reviewType:"peer-reviewed",abstract:"Advanced Oxidation Processes – Applications, Trends, and Prospects constitutes a comprehensive resource for civil, chemical, and environmental engineers researching in the field of water and wastewater treatment. The book covers the fundamentals, applications, and future work in Advanced Oxidation Processes (AOPs) as an attractive alternative and a complementary treatment option to conventional methods. This book also presents state-of-the-art research on AOPs and heterogeneous catalysis while covering recent progress and trends, including the application of AOPs at the laboratory, pilot, or industrial scale, the combination of AOPs with other technologies, hybrid processes, process intensification, reactor design, scale-up, and optimization. The book is divided into four sections: Introduction to Advanced Oxidation Processes, General Concepts of Heterogeneous Catalysis, Fenton and Ferrate in Wastewater Treatment, and Industrial Applications, Trends, and Prospects.",isbn:"978-1-78984-891-5",printIsbn:"978-1-78984-890-8",pdfIsbn:"978-1-83880-971-3",doi:"10.5772/intechopen.85681",price:119,priceEur:129,priceUsd:155,slug:"advanced-oxidation-processes-applications-trends-and-prospects",numberOfPages:182,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"60d177837fbb691b82c80922cd9bb295",bookSignature:"Ciro Bustillo-Lecompte",publishedDate:"June 10th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/9415.jpg",numberOfDownloads:8703,numberOfWosCitations:32,numberOfCrossrefCitations:20,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:58,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:110,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 6th 2019",dateEndSecondStepPublish:"June 27th 2019",dateEndThirdStepPublish:"August 26th 2019",dateEndFourthStepPublish:"November 14th 2019",dateEndFifthStepPublish:"January 13th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!0,featuredMarkup:null,editors:[{id:"189304",title:"Dr.",name:"Ciro",middleName:"Fernando",surname:"Bustillo-Lecompte",slug:"ciro-bustillo-lecompte",fullName:"Ciro Bustillo-Lecompte",profilePictureURL:"https://mts.intechopen.com/storage/users/189304/images/system/189304.jpeg",biography:"Dr. Ciro Bustillo LeCompte has a multidisciplinary background\nin the areas of civil, environmental, and chemical engineering.\nHe completed his Bachelor of Engineering (2008) at the University of Cartagena, Colombia, and obtained his MASc (2012)\nand PhD (2016) at Ryerson University, Canada. Dr. LeCompte\nis a certified Professional Engineer (PEng), Environmental\nProfessional (EP), a Fraternal Member of the Canadian Institute\nof Public Health Inspectors (CIPHI), and a 2017-2018 Queen Elizabeth Scholar\n(QES). He is currently an Associate Member in the Environmental Applied Science\nand Management Graduate Programs, and a Lecturer in the School of Occupational\nand Public Health at Ryerson University. He has co-authored over twenty peer-reviewed scientific papers, several conference proceedings, chapters, and books. His\nresearch interests include advanced oxidation processes, advanced treatment of\nwater and wastewater, waste minimization, water, soil and air quality, energy and\nresource recovery, water reuse, and heterogeneous catalysis.",institutionString:"Ryerson University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Ryerson University",institutionURL:null,country:{name:"Canada"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1354",title:"Wastewater Engineering",slug:"technology-environmental-engineering-wastewater-engineering"}],chapters:[{id:"70086",title:"Advanced Oxidation Processes: A Powerful Treatment Option for the Removal of Recalcitrant Organic Compounds",doi:"10.5772/intechopen.90192",slug:"advanced-oxidation-processes-a-powerful-treatment-option-for-the-removal-of-recalcitrant-organic-com",totalDownloads:1624,totalCrossrefCites:6,totalDimensionsCites:20,hasAltmetrics:0,abstract:"Advanced oxidation processes (AOPs) are the technologies that generally use the hydroxyl radicals, the ultimate oxidant for the remediation of organic contaminants in wastewater. These are highly effective novel methods speeding up the oxidation process. AOP can combine with ozone (O3), catalyst, or ultraviolet (UV) irradiation to offer a powerful treatment of wastewater. Future research should be focused on enhancing the properties of heterogeneous catalysts in AOPs. This chapter reports general review of different AOPs utilized for the removal of various phenolic compounds and textile dyes in wastewater. The chapter also aimed at an investigation of efficiency for different photochemical AOPs. The authors have carried out the experimental runs at a laboratory scale for the removal of malachite green oxalate (MGO) dye with photochemical AOPs. The influence of ferrous ions and oxidant dosage on percentage decolorization of MGO in wastewater has been reported. The discussion extends to the utilization of different modified photocatalysts for the photocatalysis process. The future challenges, such as the adoption of strategies for the integration of processes and the decrement in operational cost of AOPs, are discussed. The discussion covers the utilization of different heterogeneous catalysts, the reduction of input demands of chemicals and energy for the processes.",signatures:"Damodhar Ghime and Prabir Ghosh",downloadPdfUrl:"/chapter/pdf-download/70086",previewPdfUrl:"/chapter/pdf-preview/70086",authors:[{id:"251470",title:"Dr.",name:"Prabir",surname:"Ghosh",slug:"prabir-ghosh",fullName:"Prabir Ghosh"},{id:"312650",title:"Mr.",name:"Damodhar",surname:"Ghime",slug:"damodhar-ghime",fullName:"Damodhar Ghime"}],corrections:null},{id:"70440",title:"Heterogeneous Catalytic Process for Wastewater Treatment",doi:"10.5772/intechopen.90393",slug:"heterogeneous-catalytic-process-for-wastewater-treatment",totalDownloads:983,totalCrossrefCites:1,totalDimensionsCites:6,hasAltmetrics:0,abstract:"This chapter introduced heterogeneous catalysis and described diverse heterogeneous catalytic processes for wastewater treatment. The main advantages of heterogeneous catalysis were explained compared with homogeneous catalysis. The methods of synthesis and characterization of heterogeneous catalysts with some examples were then elaborated. The principle of heterogeneous catalytic treatment process of refractory wastewater was analyzed, and several different types of heterogeneous catalytic oxidation processes, technical progresses, and application examples were presented. The mechanisms of heterogeneous catalytic oxidation degradation of pollutants in wastewater were also discussed. According to the review, the heterogeneous catalytic oxidation technology was considered having a good application prospect, and the further research directions of heterogeneous catalysis were proposed.",signatures:"Ting Zhang",downloadPdfUrl:"/chapter/pdf-download/70440",previewPdfUrl:"/chapter/pdf-preview/70440",authors:[{id:"308235",title:"Dr.",name:"Ting",surname:"Zhang",slug:"ting-zhang",fullName:"Ting Zhang"}],corrections:null},{id:"71660",title:"Applications of Chemical Kinetics in Heterogeneous Catalysis",doi:"10.5772/intechopen.91939",slug:"applications-of-chemical-kinetics-in-heterogeneous-catalysis",totalDownloads:1112,totalCrossrefCites:3,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Chemical kinetics is a key subdiscipline of physical chemistry that studies the reaction rate in every elemental step and corresponding catalytic mechanism. It mainly concludes molecular reaction dynamics, catalytic dynamics, elemental reaction dynamics, macrodynamics, and microdynamics. Such a research field has wide applications in heterogeneous catalysis. Based on the Arrhenius plot fitted by the catalytic conversions below 15% without the mass transfer effect and heat transfer effect, the apparent activation energy echoing with the intrinsically catalytic sites and the pre-exponential factor echoing with the relative number of active sites can be, respectively, derived from the slope and intercept of the Arrhenius plots, which can be used to compare the intrinsically catalytic activity of different catalysts and the relative amount of active sites. Reaction orders of both reactants and products are derived from the reaction rate equation and also fitted by the catalytic conversions below 15% without the mass transfer effect and heat transfer effect. According to the acquired reaction orders, the reaction mechanism can be proposed and even defined in some simple reactions. Therefore, investigations of chemical kinetics are of extreme importance and meaning in heterogeneous catalysis.",signatures:"Zhenhua Zhang, Li-Ping Fan and Yue-Juan Wang",downloadPdfUrl:"/chapter/pdf-download/71660",previewPdfUrl:"/chapter/pdf-preview/71660",authors:[{id:"312555",title:"Prof.",name:"Zhenhua",surname:"Zhang",slug:"zhenhua-zhang",fullName:"Zhenhua Zhang"},{id:"316868",title:"Ms.",name:"Li-Ping",surname:"Fan",slug:"li-ping-fan",fullName:"Li-Ping Fan"},{id:"316869",title:"Prof.",name:"Yue-Juan",surname:"Wang",slug:"yue-juan-wang",fullName:"Yue-Juan Wang"}],corrections:null},{id:"70242",title:"Advancements in the Fenton Process for Wastewater Treatment",doi:"10.5772/intechopen.90256",slug:"advancements-in-the-fenton-process-for-wastewater-treatment",totalDownloads:1894,totalCrossrefCites:10,totalDimensionsCites:23,hasAltmetrics:0,abstract:"Fenton is considered to be one of the most effective advanced treatment processes in the removal of many hazardous organic pollutants from refractory/toxic wastewater. It has many advantages, but drawbacks are significant such as a strong acid environment, the cost of reagents consumption, and the large production of ferric sludge, which limits Fenton’s further application. The development of Fenton applications is mainly achieved by improving oxidation efficiency and reducing sludge production. This chapter presents a review on fundamentals and applications of conventional Fenton, leading advanced technologies in the Fenton process, and reuse methods of iron containing sludge to synthetic and real wastewaters are discussed. Finally, future trends and some guidelines for Fenton processes are given.",signatures:"Min Xu, Changyong Wu and Yuexi Zhou",downloadPdfUrl:"/chapter/pdf-download/70242",previewPdfUrl:"/chapter/pdf-preview/70242",authors:[{id:"307479",title:"Dr.",name:"Changyong",surname:"Wu",slug:"changyong-wu",fullName:"Changyong Wu"},{id:"307546",title:"Prof.",name:"Yuexi",surname:"Zhou",slug:"yuexi-zhou",fullName:"Yuexi Zhou"},{id:"311139",title:"Dr.",name:"Min",surname:"Xu",slug:"min-xu",fullName:"Min Xu"}],corrections:null},{id:"70285",title:"Application of Ferrate for Advanced Water and Wastewater Treatment",doi:"10.5772/intechopen.90231",slug:"application-of-ferrate-for-advanced-water-and-wastewater-treatment",totalDownloads:871,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Treatment of recalcitrant organics and inorganics present in wastewater is a major challenge. Conventional biological treatments alone are not capable of removing these toxic compounds from wastewater. To overcome these problems, advanced oxidation processes (AOPs) have been used to completely mineralize or transform the organics into simpler compounds, which can then be treated through biological processes. However, conventional AOPs result in the generation of byproducts, which are known to have higher toxicity. Among various AOPs, ferrate has been gaining popularity because of its advantages such as high oxidation potential, no byproduct formation and also non-toxic end products. The end product generated also acts as a coagulant, which thereby enhances the removal efficiency. In the present chapter, the chemical properties, preparation methods and the factors affecting the stability of ferrate were evaluated based on literature. Further, ferrate oxidation as a potential method for the treatment of both organic and inorganic pollutants in drinking and real wastewater is discussed.",signatures:"Ansaf V. Karim, Sukanya Krishnan, Lakshmi Pisharody and Milan Malhotra",downloadPdfUrl:"/chapter/pdf-download/70285",previewPdfUrl:"/chapter/pdf-preview/70285",authors:[{id:"310802",title:"Ph.D.",name:"Milan",surname:"Malhotra",slug:"milan-malhotra",fullName:"Milan Malhotra"},{id:"312701",title:"Mr.",name:"Ansaf V",surname:"Karim",slug:"ansaf-v-karim",fullName:"Ansaf V Karim"},{id:"312732",title:"Ms.",name:"Lakshmi",surname:"Pisharody",slug:"lakshmi-pisharody",fullName:"Lakshmi Pisharody"},{id:"312733",title:"Ms.",name:"Sukanya",surname:"Krishnan",slug:"sukanya-krishnan",fullName:"Sukanya Krishnan"}],corrections:null},{id:"72151",title:"Application of Advanced Oxidation Process in the Food Industry",doi:"10.5772/intechopen.92355",slug:"application-of-advanced-oxidation-process-in-the-food-industry",totalDownloads:645,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Wastewater in the food industry contains recalcitrant organic compounds and a certain degree of toxicity. Present wastewater treatment plants are insufficient in dealing with the increasing complexity of effluents from modern food industries. Improperly treaded wastewaters can lead to spoil soil and are threads to aquatic life. The reaction of these recalcitrant chemicals with reactive radicals is an efficient treatment strategy. Researchers have proposed advanced oxidation processes (AOPs) that generate reactive radicals including ozonation, UV irradiation, (photo-) Fenton process, etc. This chapter reviews laboratory-scale and pilot-scale AOPs to incorporate with conventional pre-treatment methods and to evaluate their effectiveness and factors including operation condition and catalysts to optimize the process. Further research related to novel catalyst synthesis and cost evaluation of pilot-scale study is suggested.",signatures:"Zhaoran Xin and Lars Rehmann",downloadPdfUrl:"/chapter/pdf-download/72151",previewPdfUrl:"/chapter/pdf-preview/72151",authors:[{id:"316358",title:"Dr.",name:"Lars",surname:"Rehmann",slug:"lars-rehmann",fullName:"Lars Rehmann"},{id:"322088",title:"Dr.",name:"Zhaoran",surname:"Xin",slug:"zhaoran-xin",fullName:"Zhaoran Xin"}],corrections:null},{id:"70153",title:"Catalytic Ozone Oxidation of Petrochemical Secondary Effluent: Mechanism, Application and Future Development",doi:"10.5772/intechopen.90170",slug:"catalytic-ozone-oxidation-of-petrochemical-secondary-effluent-mechanism-application-and-future-devel",totalDownloads:678,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Petrochemical secondary effluent contains toxic and refractory organic compounds, which are difficult to be further treated by traditional biological process. In China, most of the advanced treatment units have been built recently by catalytic ozone oxidation process to achieve the high-quality effluent. In this chapter, the mechanism and reaction process of catalytic ozone oxidation of petrochemical secondary effluent will be introduced in detail. With the operation of the catalytic ozone oxidation tank, a series of problems which are not taken into account at the beginning of the design have arisen. The chapter will talk about the problems concerning the biological flocs, colloidal macromolecule organic compounds, ozone mass transfer, and catalysts based on practical applications. In the last part of the chapter, the development trends of catalytic ozone oxidation of petrochemical secondary effluent will also be discussed.",signatures:"Yu Tan, Liya Fu, Changyong Wu, Yanan Li, Xiumei Sun and Yuexi Zhou",downloadPdfUrl:"/chapter/pdf-download/70153",previewPdfUrl:"/chapter/pdf-preview/70153",authors:[{id:"307479",title:"Dr.",name:"Changyong",surname:"Wu",slug:"changyong-wu",fullName:"Changyong Wu"},{id:"307546",title:"Prof.",name:"Yuexi",surname:"Zhou",slug:"yuexi-zhou",fullName:"Yuexi Zhou"},{id:"307543",title:"Dr.",name:"Yu",surname:"Tan",slug:"yu-tan",fullName:"Yu Tan"},{id:"307544",title:"Dr.",name:"Xiumei",surname:"Sun",slug:"xiumei-sun",fullName:"Xiumei Sun"},{id:"307545",title:"MSc.",name:"Yanan",surname:"Li",slug:"yanan-li",fullName:"Yanan Li"},{id:"322089",title:"Dr.",name:"Liya",surname:"Fu",slug:"liya-fu",fullName:"Liya Fu"}],corrections:null},{id:"71672",title:"Scale-Up and Optimization for Slurry Photoreactors",doi:"10.5772/intechopen.91920",slug:"scale-up-and-optimization-for-slurry-photoreactors",totalDownloads:898,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Several aspects of scale-up and optimization of heterogeneous photocatalytic reactors are detailed in the following chapter. The relevance of the dimensionless numbers, the critical factors of the photoreactor design, and the optimization methods are explored from an engineering point of view. The apparent optical thickness is the most crucial dimensionless parameter for photoreactor design and optimization; therefore, the study will be more focused on this topic. Moreover, a real case for a commercial application of the solar photocatalysis will be presented in this chapter. This full-scale plant is currently operating as an industrial wastewater treatment plant in a flexographic company located in Cali, Colombia.",signatures:"Gianluca Li Puma, Fiderman Machuca-Martínez, Miguel Mueses, José Colina-Márquez and Ciro Bustillo-Lecompte",downloadPdfUrl:"/chapter/pdf-download/71672",previewPdfUrl:"/chapter/pdf-preview/71672",authors:[{id:"189304",title:"Dr.",name:"Ciro",surname:"Bustillo-Lecompte",slug:"ciro-bustillo-lecompte",fullName:"Ciro Bustillo-Lecompte"},{id:"309822",title:"Prof.",name:"Gianluca",surname:"Li Puma",slug:"gianluca-li-puma",fullName:"Gianluca Li Puma"},{id:"309823",title:"Prof.",name:"Fiderman",surname:"Machuca-Martínez",slug:"fiderman-machuca-martinez",fullName:"Fiderman Machuca-Martínez"},{id:"309826",title:"Prof.",name:"Miguel",surname:"Mueses",slug:"miguel-mueses",fullName:"Miguel Mueses"},{id:"309827",title:"Prof.",name:"José",surname:"Colina-Márquez",slug:"jose-colina-marquez",fullName:"José Colina-Márquez"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6539",title:"Wastewater and Water Quality",subtitle:null,isOpenForSubmission:!1,hash:"011810f6bbc0d25f6590e1169231962f",slug:"wastewater-and-water-quality",bookSignature:"Taner Yonar",coverURL:"https://cdn.intechopen.com/books/images_new/6539.jpg",editedByType:"Edited by",editors:[{id:"32956",title:"Dr.",name:"Taner",surname:"Yonar",slug:"taner-yonar",fullName:"Taner Yonar"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6199",title:"Osmotically Driven Membrane Processes",subtitle:"Approach, Development and Current 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Brill",slug:"thomas-h.-brill"}]},{id:"24253",title:"Skeletal Related Events in Prostate Cancer: Important Therapeutic Considerations",slug:"skeletal-related-events-in-prostate-cancer-important-therapeutic-considerations",signatures:"Miguel Álvarez Múgica, Jesús Ma Fernández Gómez, Antonio Jalón Monzón, Verónica Bulnes Vázquez, Erasmo Miguelez and Francisco Valle González",authors:[{id:"63733",title:"Dr.",name:"Miguel",middleName:null,surname:"Álvarez-Múgica",fullName:"Miguel Álvarez-Múgica",slug:"miguel-alvarez-mugica"},{id:"117909",title:"Prof.",name:"Jesus María",middleName:null,surname:"Fernández Gómez",fullName:"Jesus María Fernández Gómez",slug:"jesus-maria-fernandez-gomez"},{id:"117910",title:"Dr.",name:"Antonio",middleName:null,surname:"Jalón Monzón",fullName:"Antonio Jalón Monzón",slug:"antonio-jalon-monzon"},{id:"117912",title:"Dr.",name:"Verónica",middleName:null,surname:"Bulnes Vázquez",fullName:"Verónica Bulnes Vázquez",slug:"veronica-bulnes-vazquez"},{id:"122952",title:"Dr.",name:"Erasmo",middleName:null,surname:"Miguelez",fullName:"Erasmo Miguelez",slug:"erasmo-miguelez"},{id:"122953",title:"Dr.",name:"Francisco",middleName:null,surname:"Valle González",fullName:"Francisco Valle González",slug:"francisco-valle-gonzandatildeandiexcllez"}]},{id:"24254",title:"Androgen Deprivation Therapy for Prostate Cancer",slug:"androgen-deprivation-therapy-for-prostate-cancer",signatures:"Stanislav Ziaran",authors:[{id:"73226",title:"Dr.",name:"Stanislav",middleName:null,surname:"Ziaran, PhD., Mph, Febu",fullName:"Stanislav Ziaran, PhD., Mph, Febu",slug:"stanislav-ziaran-phd.-mph-febu"}]},{id:"24255",title:"A Review of Quality of Life Following Treatments for Localized Prostate Cancer",slug:"a-review-of-quality-of-life-following-treatments-for-localized-prostate-cancer",signatures:"Sunao Shoji",authors:[{id:"63316",title:"Dr.",name:"Sunao",middleName:null,surname:"Shoji",fullName:"Sunao Shoji",slug:"sunao-shoji"}]},{id:"24256",title:"Intermittent Androgen Suppression Therapy for Prostate Cancer Patients: A Choice for Improved Quality of Life?",slug:"intermittent-androgen-suppression-therapy-for-prostate-cancer-patients-a-choice-for-improved-quality",signatures:"Gerhard Hamilton, Ulrike Olszewski-Hamilton and Gerhard Theyer",authors:[{id:"67794",title:"Prof.",name:"Gerhard",middleName:null,surname:"Hamilton",fullName:"Gerhard Hamilton",slug:"gerhard-hamilton"}]}]}],publishedBooks:[{type:"book",id:"777",title:"Prostate Cancer",subtitle:"From Bench to Bedside",isOpenForSubmission:!1,hash:"d5a01877eb8f560e8aeee899be80f547",slug:"prostate-cancer-from-bench-to-bedside",bookSignature:"Philippe E. Spiess",coverURL:"https://cdn.intechopen.com/books/images_new/777.jpg",editedByType:"Edited by",editors:[{id:"64476",title:"Dr.",name:"Philippe E.",surname:"Spiess",slug:"philippe-e.-spiess",fullName:"Philippe E. Spiess"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],publishedBooksByAuthor:[{type:"book",id:"777",title:"Prostate Cancer",subtitle:"From Bench to Bedside",isOpenForSubmission:!1,hash:"d5a01877eb8f560e8aeee899be80f547",slug:"prostate-cancer-from-bench-to-bedside",bookSignature:"Philippe E. Spiess",coverURL:"https://cdn.intechopen.com/books/images_new/777.jpg",editedByType:"Edited by",editors:[{id:"64476",title:"Dr.",name:"Philippe E.",surname:"Spiess",slug:"philippe-e.-spiess",fullName:"Philippe E. Spiess"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3274",title:"Advances in Prostate Cancer",subtitle:null,isOpenForSubmission:!1,hash:"fb7257d982e3228ceb9320f595ae1c58",slug:"advances-in-prostate-cancer",bookSignature:"Gerhard Hamilton",coverURL:"https://cdn.intechopen.com/books/images_new/3274.jpg",editedByType:"Edited by",editors:[{id:"67794",title:"Prof.",name:"Gerhard",surname:"Hamilton",slug:"gerhard-hamilton",fullName:"Gerhard Hamilton"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"81032",title:"Healthcare and Hygiene Products Application in Medical Textile",doi:"10.5772/intechopen.103662",slug:"healthcare-and-hygiene-products-application-in-medical-textile",body:'An important and growing part of the textile industry is the medical and related healthcare and hygiene sectors. The extent of growth is due to constant improvement and innovations in both textile technology and medical procedures. A critical and developing part of the fabric Industry is the clinical and associated healthcare and hygiene sectors. Textile has usually been part of healthcare [1]. The variety of merchandise to be had is sizeable however normally they are used inside the running room theatre or at the health centre ward for the hygiene, care and protection of personnel and patients. The range of programmes variety from the easy cleansing wipe to the superior barrier fabric used for running rooms. Medical textiles constitute systems designed and executed for scientific software [2]. The range of programs is diverse, starting from an unmarried thread suture to the complicated composite systems for bone alternative and from the easy cleansing wipe to superior barrier fabric utilized in running rooms. Textile substances and products, which have been engineered to fulfil precise needs, are appropriate for any scientific and surgical software wherein a mixture of strength, flexibility and from time to time moisture and air permeability is required.
Textile materials and products that have been engineered to meet particular needs are suitable for any medical and surgical applications, where a combination of strength, flexibility and sometimes moisture and air permeability are required [3, 4].
Textile has usually been a part of healthcare. The variety of merchandise to be had is sizeable; however, normally they may be used inside the working room theatre or at the health facility ward for the hygiene, care and protection of workforce and patients. The quantity of packages variety from the easy cleansing wipes to the superior barrier fabric used for working rooms [5].
The medical textile fabric merchandise may be prepared into three simple categories
Patient specific: sponges, sheets, burn sheets etc.
General patient management: Under-pads, adult diapers and wipes
Procedure specific: sterilization wrap, surgical gowns, drapes, table covers, face masks, head and shoe covers.
Nontoxicity
Non-allergenic response
The ability to be sterilized
Elasticity, durability
Biocompatibility
Fast and highly absorbent
Static dissipation
Antimicrobial
Wide range of staple fibres are used for the hygiene sector and technical application (Table 1)
Bi-component fibres for thermal bonding, used in hygiene articles such as sanitary napkins, baby diapers, etc.
Special types for hydro-entangled nonwovens are not only employed in the manufacturer of wet and cosmetic wipes but also increasingly in technical applications.
Fibres made from biopolymers (PLA/Ingeo) include fibres made from renewable plant compounds
Fill fibres for beds.
Used medical application | Type of fibre used | Cloth type |
---|---|---|
Cover cloths and Surgical drapes | Polyester and polyethylene | Nonwoven or woven |
Absorbent layer Outer layer, Incontinence and diaper Cover stock | Polyester, polypropylene Wood fluff and Super-absorbents Polyethylene fibres | Nonwoven |
Protective clothing and Clothing uniforms | Cotton, polyester and polypropylene | Woven and Nonwoven |
Surgical hosiery garments products | Polyamide, polyester, cotton and elastomeric yarn | Nonwoven and Knitted |
Wipes and garments | Viscose rayon | Nonwoven |
Masks and caps etc. | Viscose rayon, polyester, viscose and glass | Nonwoven |
Pillow covers, sheets and Bedding, Blanket | Cotton, polyester and cotton | Woven and knitted |
Surgical gowns garments | Cotton, polyester, viscose rayon and polypropylene | Nonwoven and Woven |
Non-woven possesses the following properties due to which they became famous in medical field:
Various parameters can be controlled easily like porosity, weight of fabric, thickness.
Nonwovens are easy to sterilise
Various manufacturing technique options according to applications.
Economical manufacturing process.
These encompass surgeon`s gowns, caps and masks, affected person drapes and cowl cloths of all sizes. The reason for defensive healthcare clothes is to defend healthcare experts from infection from blood and different infectious fluids [6, 7]. Biological defensive clothes are described through the Occupational Safety and Health Administration (OSHA) as follows: `Personal defensive garb may be taken into consideration suitable most effective if it does now no longer allow blood and different infectious substances to by skip thru to attain an employee`s paintings clothes, road clothes, undergarment, pores and skin, eyes, mouth or different mucous membranes below the ordinary situations of use and at some point of time the protection system may be used` According to this definition, there are fundamental necessities for a defensive fabric garment: it ought to save you infectious substances from passing thru the pores and skin and it ought to closing lengthy enough. Protective clothing inside the clinical subject ought to be affordable, breathable, comfortable, dependable, and effective [8].
Main issue in design and use of operating room fabric used to be is the protection of the patient from contamination by the environment and by healthcare workers. The principle design features for medical non-woven fabric are barrier properties, strength, sterilization stability, breathability and comfort for garment application.
Barrier performance can be partial (resistant) or total (proof) ranging from particulates and bacteria to fluids and viruses. The principal necessities for barrier fabric are that they withstand the penetration of liquids, especially blood and on the equal time be sterile, breathable, bendy and cheaper. Because of those necessities, maximum of the barrier clothes are crafted from non-woven fabric, which can be exceedingly cheaper and may be thrown away after every use, hence lowering the want for re-sterilization. In a few cases, unique breathable movies are being brought to fibres and fabric. In different cases, components are being brought without delay into polymers getting used to making the fibres. Theatre drapes are meant to shape a barrier in opposition to contamination each to and more good from the patient. Strength requirements vary with end-use application. For surgical drapes, stiffness is very critical because barrier performance may be affected by comorbidity to patient or equipment. Good abrasion resistance is necessary for the safety of barrier administration. The consumer product safety commissions (CPSC) require 3.5sec burn time on CS-191-53 for gowns, head covering and surgical mask [9, 10, 11].
Many hospitals have delivered peroxide plasma systems, inclusive of STERRAD, to their steam autoclaves and ethylene oxide chambers inside the Central Supply Room. In designing fabric for sterilization, it is far critical to apprehend the effect of sterilization tactics on material overall performance features. Steam autoclaves typically function at 132°C. Fabrics containing cellulose are not typically advocated for the plasma gadgets as those fabrics hold residual peroxide.
The consolation and breathability components are commonly taken into consideration as opposing the barrier performance. For sterilization wrap, the difficulty is that the barrier should save you dirt and micro-organisms from penetrating a sterilized bundle in the course of garage and transportation. At an equal time, it should be porous sufficient for the sterilant to penetrate the wrapped bundle and absolutely sterilize the content material of the surgical set.
For gowns, linting is not wanted because particles from gowns or drapes may complicate the wound healing process. In general, it is accepted that particles above 50μm are readily visible to the unaided eye.
Treated fabric articles can encompass clinical textiles consisting of pads, face masks, surgical gowns, ambulance blankets, stretchers, and clear out substances and diapers [12].
High overall performance fibres had been evolved which save you risky microorganism from buildup and could discover programs with inside the fields of private hygiene wherein buildup of risky microorganism may be risky to health: the fibre essentially includes a mixture of antimicrobial compounds, primarily based totally on steel salts which in the end controls microorganism and fungi. The compounds are embedded inside the matrix of fibres which renders it impervious to washing and wear [13].
Surgical gowns are worn during medical procedures, to prevent contamination by splattering of body fluids such as blood, respiratory secretions, vomit or feces during medical procedures.
Surgical gowns are made of fluid-resistant materials to reduce the transfer of body fluids (Figure 1). Isolation gowns are usually intended to protect the wearer from the transfer of micro-organisms and only small amount of body fluids [14].
Surgical gowns, healthcare and hygiene products [
They should have high level of air permeability, high filter capacity, and should be light weight and non-allergic .
Materials: consist of a very fine middle layer of extra fine glass fibres or synthetic micro fibres covered on both sides by either an acrylic bonded parallel-laid or wet-laid non-woven (Figure 2).
Surgical masks products [
These are used to cover patients or working areas around patients.
Material: loop raised warp-knitted polyester fabric laminated with PTFE films for air permeability, comfort and resistance to microbiological contaminants [15].
Surgical hosiery with graduated compression traits is used for wide variety of purposes, starting from a mild help for the limb to the remedy of venous disorders. Knee and elbow caps, which might be commonly fashioned throughout knitting on round machines and might additionally comprise elastomeric threads are worn for help and compression throughout bodily energetic sports activities or for protection.
Such as bedding garb, bed covers, incontinence merchandise are used for care and hygiene of patients. The conventional Woollen blankets had been changed with cotton leno woven blankets to lessen the threat of pass contamination and are crafted from smooth spun two-fold yarns which own suited thermal qualities. In isolation wards and in-depth care units, disposable defensive garb is worn to reduce pass contamination and are made from composite of tissue strengthened with a PET or polypropylene spunlaid web [16].
These include gauze for floors, dry dusting systems; hard surface disinfectant wipes high absorbency cloth, window cloth, electrostatic disposable dusters, cleaning mop, etc.
Figure 3 classify of three layers:
Inner pinnacle layer: fabricated from a mix of hydrophobic low-density fibre and is liquid and water permeable.
Core layer: full of wooden pulp and different absorbent fabric is especially absorbent.
Third layer encompasses multi-layer barrier, this is water vapour permeable, however persistent to liquid water.
Modern breathable disposable feminine products [
Modern incontinence product also consists of three layers.
Cover stock that is permeable and diffuses liquid laterally. Highly absorbent core and barrier polyethylene or PVC films that help patient cloths or bedding to keep dry.
Laboratory exams consist of water repellency, launder ability, burst electricity and tear electricity. The layout of barrier fabric is pushed with the aid of using the priority over HIV. Therefore, for those fabric check techniques that might help with inside the Characterisation of merchandise as blood-resistant, blood-evidence or viral evidence. These techniques were installed as ASTM 1670-95 and 1671-97.
The call for wettability approach of measuring the absorbency traits of fabric was defined with the aid of using Lichstein. This method measures each capability and absorption price concurrently at zero hydrostatic head. It is relevant to distinctive absorbents, wicking fluids and more than one ply system with the absorbent at any attitude to the fluid and below distinctive pressure [17].
Bio-purposeful substances are starting up new opportunities for the medical fabric sector. Here energetic materials are included in the fibre with the aid of using chemical change or implemented onto the fibre floor at some point of the spinning process. These components are transferred to the pores and skin with the aid of using frame moisture and frame warmth with stepped forward bioclimatic and hygienic homes such as.
Protection to the pores and skin from liquids, debris and bacteria.
Providing a powerful barrier towards germs, fungi and danger of infection.
Thermo regularity characteristic.
Ease of laundering, sterilization and anti-static behaviour
Low stage of fabric chemical compounds and dyes with excessive mechanical stability.
New fabric is evolved to face up to bacteria, mildew, stain and odour for healthcare applications. For example, anti-allergen completing retailers are used on material to offer themselves remedy to sufferers from bronchial allergies and allergic reactions as a result of dirt mites.
Active substances can also be made available to the skin as an aqueous solution by micro-encapsulation or by their insertion into water-absorbing network polymers, which are affixed to the fibre. Advanced processes also offer the potential for the development of bioactive, drug-delivering textiles and the controlled treatment of diseases.
Ideal bedding materials attribute the following
Convenient during changing and to wash
Breathable
Absorbent
Durable
Odour free
Now allergic
Hygienic
Easy to care for and store
Prevent liquid and soil spread around
Colour and pattern of the fabric (not significant for elderly)
Provide comfort support
Keep patient clean after being soiled
Smooth to the touch
Keep patient warm after being wetted
Soft to touch dry after being wetted
The application of textile in high performance and specialized fields are increasing day by day. There will be an increasing role for medical textiles in future.
Textile substances hold to serve a critical characteristic with inside the improvement of number clinical and surgical products.
The advent of recent substances, the development in manufacturing strategies and fibre properties, and the usage of greater correct and complete trying out have all had a giant impact on advancing fibres and fabric for clinical applications.
Advances in nonwovens have ended in a brand new breed of clinical textiles. Advanced composite material containing a combination of fibres and fabrics has been developed for applications where biocompatibility and strength are required.
As medical procedures continue to develop, the demand for textile material is bound to grow.
Ove Odredbe i uvjeti ističu pravila i regulacije u svezi korištenja IntechOpenove stranice www.intechopen.com i svih poddomena u vlasništvu IntechOpena, tvrtke sa sjedištem u 5 Princes Gate Court, London, SW7 2QJ, Ujedinjeno Kraljevstvo.
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\n\nSljedeća terminologija odnosi se na Odredbe i uvjete, te na sve naše ugovore:
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\n\nKompanija, tvrtka, mi, naše odnosi se na tvrtku IntechOpen;
\n\nStranke, strane odnosi se na klijenta i na nas, ili samo na klijenta ili nas.
\n\nSve odredbe koje se odnose na ponudu, prihvat ili razmatranje plaćanja, a za koja mi pružamo asistenciju klijentu, bilo na ugovoreni ili fiksni način, a s ciljem da se ostvare potrebe i želje klijenta u svezi s našim uslugama, su podložne zakonskim odredbama Ujedinjenog Kraljevstva.
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\n\nMi koristimo kolačiće. Korištenjem IntechOpenove stranice slažete se s korištenjem kolačića u skladu s IntechOpenovom Politikom privatnosti. Većina modernih, interaktivnih stranica koristi kolačiće kako bi omogućila ponovno pronalaženje korisničkih detalja kod svakog posjeta. Na našoj stranici kolačići se uglavnom koriste kako bi omogućili funkcionalnost i olakšali posjetiteljima korištenje stranice.
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MRI is commonly used once treating brain, prostate cancers, ankle and foot. The Magnetic Resonance Imaging (MRI) images are usually liable to suffer from noises such as Gaussian noise, salt and pepper noise and speckle noise. So getting of brain image with accuracy is very extremely task. An accurate brain image is very necessary for further diagnosis process. During this chapter, a median filter algorithm will be modified. Gaussian noise and Salt and pepper noise will be added to MRI image. A proposed Median filter (MF), Adaptive Median filter (AMF) and Adaptive Wiener filter (AWF) will be implemented. The filters will be used to remove the additive noises present in the MRI images. The noise density will be added gradually to MRI image to compare performance of the filters evaluation. The performance of these filters will be compared exploitation the applied mathematics parameter Peak Signal-to-Noise Ratio (PSNR).",book:{id:"6144",slug:"high-resolution-neuroimaging-basic-physical-principles-and-clinical-applications",title:"High-Resolution Neuroimaging",fullTitle:"High-Resolution Neuroimaging - Basic Physical Principles and Clinical Applications"},signatures:"Hanafy M. Ali",authors:[{id:"213318",title:"Dr.",name:"Hanafy",middleName:"M.",surname:"Ali",slug:"hanafy-ali",fullName:"Hanafy Ali"}]},{id:"41589",doi:"10.5772/50323",title:"The Role of the Amygdala in Anxiety Disorders",slug:"the-role-of-the-amygdala-in-anxiety-disorders",totalDownloads:9671,totalCrossrefCites:4,totalDimensionsCites:28,abstract:null,book:{id:"2599",slug:"the-amygdala-a-discrete-multitasking-manager",title:"The Amygdala",fullTitle:"The Amygdala - A Discrete Multitasking Manager"},signatures:"Gina L. Forster, Andrew M. Novick, Jamie L. Scholl and Michael J. Watt",authors:[{id:"145620",title:"Dr.",name:"Gina",middleName:null,surname:"Forster",slug:"gina-forster",fullName:"Gina Forster"},{id:"146553",title:"BSc.",name:"Andrew",middleName:null,surname:"Novick",slug:"andrew-novick",fullName:"Andrew Novick"},{id:"146554",title:"MSc.",name:"Jamie",middleName:null,surname:"Scholl",slug:"jamie-scholl",fullName:"Jamie Scholl"},{id:"146555",title:"Dr.",name:"Michael",middleName:null,surname:"Watt",slug:"michael-watt",fullName:"Michael Watt"}]},{id:"26258",doi:"10.5772/28300",title:"Excitotoxicity and Oxidative Stress in Acute Ischemic Stroke",slug:"excitotoxicity-and-oxidative-stress-in-acute-ischemic-stroke",totalDownloads:7157,totalCrossrefCites:6,totalDimensionsCites:25,abstract:null,book:{id:"931",slug:"acute-ischemic-stroke",title:"Acute Ischemic Stroke",fullTitle:"Acute Ischemic Stroke"},signatures:"Ramón Rama Bretón and Julio César García Rodríguez",authors:[{id:"73430",title:"Prof.",name:"Ramon",middleName:null,surname:"Rama",slug:"ramon-rama",fullName:"Ramon Rama"},{id:"124643",title:"Prof.",name:"Julio Cesar",middleName:null,surname:"García",slug:"julio-cesar-garcia",fullName:"Julio Cesar García"}]},{id:"62072",doi:"10.5772/intechopen.78695",title:"Brain-Computer Interface and Motor Imagery Training: The Role of Visual Feedback and Embodiment",slug:"brain-computer-interface-and-motor-imagery-training-the-role-of-visual-feedback-and-embodiment",totalDownloads:1439,totalCrossrefCites:13,totalDimensionsCites:23,abstract:"Controlling a brain-computer interface (BCI) is a difficult task that requires extensive training. Particularly in the case of motor imagery BCIs, users may need several training sessions before they learn how to generate desired brain activity and reach an acceptable performance. A typical training protocol for such BCIs includes execution of a motor imagery task by the user, followed by presentation of an extending bar or a moving object on a computer screen. In this chapter, we discuss the importance of a visual feedback that resembles human actions, the effect of human factors such as confidence and motivation, and the role of embodiment in the learning process of a motor imagery task. Our results from a series of experiments in which users BCI-operated a humanlike android robot confirm that realistic visual feedback can induce a sense of embodiment, which promotes a significant learning of the motor imagery task in a short amount of time. We review the impact of humanlike visual feedback in optimized modulation of brain activity by the BCI users.",book:{id:"6610",slug:"evolving-bci-therapy-engaging-brain-state-dynamics",title:"Evolving BCI Therapy",fullTitle:"Evolving BCI Therapy - Engaging Brain State Dynamics"},signatures:"Maryam Alimardani, Shuichi Nishio and Hiroshi Ishiguro",authors:[{id:"11981",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Ishiguro",slug:"hiroshi-ishiguro",fullName:"Hiroshi Ishiguro"},{id:"231131",title:"Dr.",name:"Maryam",middleName:null,surname:"Alimardani",slug:"maryam-alimardani",fullName:"Maryam Alimardani"},{id:"231134",title:"Dr.",name:"Shuichi",middleName:null,surname:"Nishio",slug:"shuichi-nishio",fullName:"Shuichi Nishio"}]}],mostDownloadedChaptersLast30Days:[{id:"29764",title:"Underlying Causes of Paresthesia",slug:"underlying-causes-of-paresthesia",totalDownloads:192666,totalCrossrefCites:3,totalDimensionsCites:7,abstract:null,book:{id:"1069",slug:"paresthesia",title:"Paresthesia",fullTitle:"Paresthesia"},signatures:"Mahdi Sharif-Alhoseini, Vafa Rahimi-Movaghar and Alexander R. Vaccaro",authors:[{id:"91165",title:"Prof.",name:"Vafa",middleName:null,surname:"Rahimi-Movaghar",slug:"vafa-rahimi-movaghar",fullName:"Vafa Rahimi-Movaghar"}]},{id:"63258",title:"Anatomy and Function of the Hypothalamus",slug:"anatomy-and-function-of-the-hypothalamus",totalDownloads:4558,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"The hypothalamus is a small but important area of the brain formed by various nucleus and nervous fibers. Through its neuronal connections, it is involved in many complex functions of the organism such as vegetative system control, homeostasis of the organism, thermoregulation, and also in adjusting the emotional behavior. The hypothalamus is involved in different daily activities like eating or drinking, in the control of the body’s temperature and energy maintenance, and in the process of memorizing. It also modulates the endocrine system through its connections with the pituitary gland. Precise anatomical description along with a correct characterization of the component structures is essential for understanding its functions.",book:{id:"6331",slug:"hypothalamus-in-health-and-diseases",title:"Hypothalamus in Health and Diseases",fullTitle:"Hypothalamus in Health and Diseases"},signatures:"Miana Gabriela Pop, Carmen Crivii and Iulian Opincariu",authors:null},{id:"57103",title:"GABA and Glutamate: Their Transmitter Role in the CNS and Pancreatic Islets",slug:"gaba-and-glutamate-their-transmitter-role-in-the-cns-and-pancreatic-islets",totalDownloads:3478,totalCrossrefCites:3,totalDimensionsCites:9,abstract:"Glutamate and gamma-aminobutyric acid (GABA) are the major neurotransmitters in the mammalian brain. Inhibitory GABA and excitatory glutamate work together to control many processes, including the brain’s overall level of excitation. The contributions of GABA and glutamate in extra-neuronal signaling are by far less widely recognized. In this chapter, we first discuss the role of both neurotransmitters during development, emphasizing the importance of the shift from excitatory to inhibitory GABAergic neurotransmission. The second part summarizes the biosynthesis and role of GABA and glutamate in neurotransmission in the mature brain, and major neurological disorders associated with glutamate and GABA receptors and GABA release mechanisms. The final part focuses on extra-neuronal glutamatergic and GABAergic signaling in pancreatic islets of Langerhans, and possible associations with type 1 diabetes mellitus.",book:{id:"6237",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",title:"GABA And Glutamate",fullTitle:"GABA And Glutamate - New Developments In Neurotransmission Research"},signatures:"Christiane S. Hampe, Hiroshi Mitoma and Mario Manto",authors:[{id:"210220",title:"Prof.",name:"Christiane",middleName:null,surname:"Hampe",slug:"christiane-hampe",fullName:"Christiane Hampe"},{id:"210485",title:"Prof.",name:"Mario",middleName:null,surname:"Manto",slug:"mario-manto",fullName:"Mario Manto"},{id:"210486",title:"Prof.",name:"Hiroshi",middleName:null,surname:"Mitoma",slug:"hiroshi-mitoma",fullName:"Hiroshi Mitoma"}]},{id:"35802",title:"Cross-Cultural/Linguistic Differences in the Prevalence of Developmental Dyslexia and the Hypothesis of Granularity and Transparency",slug:"cross-cultural-linguistic-differences-in-the-prevalence-of-developmental-dyslexia-and-the-hypothesis",totalDownloads:3601,totalCrossrefCites:2,totalDimensionsCites:7,abstract:null,book:{id:"673",slug:"dyslexia-a-comprehensive-and-international-approach",title:"Dyslexia",fullTitle:"Dyslexia - A Comprehensive and International Approach"},signatures:"Taeko N. Wydell",authors:[{id:"87489",title:"Prof.",name:"Taeko",middleName:"N.",surname:"Wydell",slug:"taeko-wydell",fullName:"Taeko Wydell"}]},{id:"58597",title:"Testosterone and Erectile Function: A Review of Evidence from Basic Research",slug:"testosterone-and-erectile-function-a-review-of-evidence-from-basic-research",totalDownloads:1331,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Androgens are essential for male physical activity and normal erectile function. Hence, age-related testosterone deficiency, known as late-onset hypogonadism (LOH), is considered a risk factor for erectile dysfunction (ED). This chapter summarizes relevant basic research reports examining the effects of testosterone on erectile function. Testosterone affects several organs and is especially active on the erectile tissue. The mechanism of testosterone deficiency effects on erectile function and the results of testosterone replacement therapy (TRT) have been well studied. Testosterone affects nitric oxide (NO) production and phosphodiesterase type 5 (PDE-5) expression in the corpus cavernosum through molecular pathways, preserves smooth muscle contractility by regulating both contraction and relaxation, and maintains the structure of the corpus cavernosum. Interestingly, testosterone deficiency has relationship to neurological diseases, which leads to ED. Testosterone replacement therapy is widely used to treat patients with testosterone deficiency; however, this treatment might also induce some problems. Basic research suggests that PDE-5 inhibitors, L-citrulline, and/or resveratrol therapy might be effective therapeutic options for testosterone deficiency-induced ED. Future research should confirm these findings through more specific experiments using molecular tools and may shed more light on endocrine-related ED and its possible treatments.",book:{id:"5994",slug:"sex-hormones-in-neurodegenerative-processes-and-diseases",title:"Sex Hormones in Neurodegenerative Processes and Diseases",fullTitle:"Sex Hormones in Neurodegenerative Processes and Diseases"},signatures:"Tomoya Kataoka and Kazunori Kimura",authors:[{id:"219042",title:"Ph.D.",name:"Tomoya",middleName:null,surname:"Kataoka",slug:"tomoya-kataoka",fullName:"Tomoya Kataoka"},{id:"229066",title:"Prof.",name:"Kazunori",middleName:null,surname:"Kimura",slug:"kazunori-kimura",fullName:"Kazunori Kimura"}]}],onlineFirstChaptersFilter:{topicId:"18",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"81646",title:"Cortical Plasticity under Ketamine: From Synapse to Map",slug:"cortical-plasticity-under-ketamine-from-synapse-to-map",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.104787",abstract:"Sensory systems need to process signals in a highly dynamic way to efficiently respond to variations in the animal’s environment. For instance, several studies showed that the visual system is subject to neuroplasticity since the neurons’ firing changes according to stimulus properties. This dynamic information processing might be supported by a network reorganization. Since antidepressants influence neurotransmission, they can be used to explore synaptic plasticity sustaining cortical map reorganization. To this goal, we investigated in the primary visual cortex (V1 of mouse and cat), the impact of ketamine on neuroplasticity through changes in neuronal orientation selectivity and the functional connectivity between V1 cells, using cross correlation analyses. We found that ketamine affects cortical orientation selectivity and alters the functional connectivity within an assembly. These data clearly highlight the role of the antidepressant drugs in inducing or modeling short-term plasticity in V1 which suggests that cortical processing is optimized and adapted to the properties of the stimulus.",book:{id:"11374",title:"Sensory Nervous System - Computational Neuroimaging Investigations of Topographical Organization in Human Sensory Cortex",coverURL:"https://cdn.intechopen.com/books/images_new/11374.jpg"},signatures:"Ouelhazi Afef, Rudy Lussiez and Molotchnikoff Stephane"},{id:"81582",title:"The Role of Cognitive Reserve in Executive Functioning and Its Relationship to Cognitive Decline and Dementia",slug:"the-role-of-cognitive-reserve-in-executive-functioning-and-its-relationship-to-cognitive-decline-and",totalDownloads:23,totalDimensionsCites:0,doi:"10.5772/intechopen.104646",abstract:"In this chapter, we explore how cognitive reserve is implicated in coping with the negative consequences of brain pathology and age-related cognitive decline. Individual differences in cognitive performance are based on different brain mechanisms (neural reserve and neural compensation), and reflect, among others, the effect of education, occupational attainment, leisure activities, and social involvement. These cognitive reserve proxies have been extensively associated with efficient executive functioning. We discuss and focus particularly on the compensation mechanisms related to the frontal lobe and its protective role, in maintaining cognitive performance in old age or even mitigating the clinical expression of dementia.",book:{id:"11742",title:"Neurophysiology",coverURL:"https://cdn.intechopen.com/books/images_new/11742.jpg"},signatures:"Gabriela Álvares-Pereira, Carolina Maruta and Maria Vânia Silva-Nunes"},{id:"81488",title:"Aggression and Sexual Behavior: Overlapping or Distinct Roles of 5-HT1A and 5-HT1B Receptors",slug:"aggression-and-sexual-behavior-overlapping-or-distinct-roles-of-5-ht1a-and-5-ht1b-receptors",totalDownloads:20,totalDimensionsCites:0,doi:"10.5772/intechopen.104872",abstract:"Distinct brain mechanisms for male aggressive and sexual behavior are present in mammalian species, including man. However, recent evidence suggests a strong connection and even overlap in the central nervous system (CNS) circuitry involved in aggressive and sexual behavior. The serotonergic system in the CNS is strongly involved in male aggressive and sexual behavior. In particular, 5-HT1A and 5-HT1B receptors seem to play a critical role in the modulation of these behaviors. The present chapter focuses on the effects of 5-HT1A- and 5-HT1B-receptor ligands in male rodent aggression and sexual behavior. Results indicate that 5-HT1B-heteroreceptors play a critical role in the modulation of male offensive behavior, although a definite role of 5-HT1A-auto- or heteroreceptors cannot be ruled out. 5-HT1A receptors are clearly involved in male sexual behavior, although it has to be yet unraveled whether 5-HT1A-auto- or heteroreceptors are important. Although several key nodes in the complex circuitry of aggression and sexual behavior are known, in particular in the medial hypothalamus, a clear link or connection to these critical structures and the serotonergic key receptors is yet to be determined. This information is urgently needed to detect and develop new selective anti-aggressive (serenic) and pro-sexual drugs for human applications.",book:{id:"10195",title:"Serotonin and the CNS - New Developments in Pharmacology and Therapeutics",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg"},signatures:"Berend Olivier and Jocelien D.A. Olivier"},{id:"81093",title:"Prehospital and Emergency Room Airway Management in Traumatic Brain Injury",slug:"prehospital-and-emergency-room-airway-management-in-traumatic-brain-injury",totalDownloads:49,totalDimensionsCites:0,doi:"10.5772/intechopen.104173",abstract:"Airway management in trauma is critical and may impact patient outcomes. Particularly in traumatic brain injury (TBI), depressed level of consciousness may be associated with compromised protective airway reflexes or apnea, which can increase the risk of aspiration or result in hypoxemia and worsen the secondary brain damage. Therefore, patients with TBI and Glasgow Coma Scale (GCS) ≤ 8 have been traditionally managed by prehospital or emergency room (ER) endotracheal intubation. However, recent evidence challenged this practice and even suggested that routine intubation may be harmful. This chapter will address the indications and optimal method of securing the airway, prehospital and in the ER, in patients with traumatic brain injury.",book:{id:"11367",title:"Traumatic Brain Injury",coverURL:"https://cdn.intechopen.com/books/images_new/11367.jpg"},signatures:"Dominik A. Jakob, Jean-Cyrille Pitteloud and Demetrios Demetriades"},{id:"81011",title:"Amino Acids as Neurotransmitters. The Balance between Excitation and Inhibition as a Background for Future Clinical Applications",slug:"amino-acids-as-neurotransmitters-the-balance-between-excitation-and-inhibition-as-a-background-for-f",totalDownloads:19,totalDimensionsCites:0,doi:"10.5772/intechopen.103760",abstract:"For more than 30 years, amino acids have been well-known (and essential) participants in neurotransmission. They act as both neuromediators and metabolites in nervous tissue. Glycine and glutamic acid (glutamate) are prominent examples. These amino acids are agonists of inhibitory and excitatory membrane receptors, respectively. Moreover, they play essential roles in metabolic pathways and energy transformation in neurons and astrocytes. Despite their obvious effects on the brain, their potential role in therapeutic methods remains uncertain in clinical practice. In the current chapter, a comparison of the crosstalk between these two systems, which are responsible for excitation and inhibition in neurons, is presented. The interactions are discussed at the metabolic, receptor, and transport levels. Reaction-diffusion and a convectional flow into the interstitial fluid create a balanced distribution of glycine and glutamate. Indeed, the neurons’ final physiological state is a result of a balance between the excitatory and inhibitory influences. However, changes to the glycine and/or glutamate pools under pathological conditions can alter the state of nervous tissue. Thus, new therapies for various diseases may be developed on the basis of amino acid medication.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Yaroslav R. Nartsissov"},{id:"80821",title:"Neuroimmunology and Neurological Manifestations of COVID-19",slug:"neuroimmunology-and-neurological-manifestations-of-covid-19",totalDownloads:41,totalDimensionsCites:0,doi:"10.5772/intechopen.103026",abstract:"Infection with SARS-CoV-2 is causing coronavirus disease in 2019 (COVID-19). Besides respiratory symptoms due to an attack on the broncho-alveolar system, COVID-19, among others, can be accompanied by neurological symptoms because of the affection of the nervous system. These can be caused by intrusion by SARS-CoV-2 of the central nervous system (CNS) and peripheral nervous system (PNS) and direct infection of local cells. In addition, neurological deterioration mediated by molecular mimicry to virus antigens or bystander activation in the context of immunological anti-virus defense can lead to tissue damage in the CNS and PNS. In addition, cytokine storm caused by SARS-CoV-2 infection in COVID-19 can lead to nervous system related symptoms. Endotheliitis of CNS vessels can lead to vessel occlusion and stroke. COVID-19 can also result in cerebral hemorrhage and sinus thrombosis possibly related to changes in clotting behavior. Vaccination is most important to prevent COVID-19 in the nervous system. There are symptomatic or/and curative therapeutic approaches to combat COVID-19 related nervous system damage that are partly still under study.",book:{id:"10890",title:"Recent Advances in Neurochemistry",coverURL:"https://cdn.intechopen.com/books/images_new/10890.jpg"},signatures:"Robert Weissert"}],onlineFirstChaptersTotal:17},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:87,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:99,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:27,numberOfPublishedChapters:289,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:9,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:11,numberOfPublishedChapters:139,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:8,numberOfPublishedChapters:129,numberOfOpenTopics:0,numberOfUpcomingTopics:2,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!1},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:1,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:104,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:12,numberOfOpenTopics:2,numberOfUpcomingTopics:1,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:0,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!1},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:4,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"May 27th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:27,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",slug:"miroslav-blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:4,paginationItems:[{id:"14",title:"Cell and Molecular Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",isOpenForSubmission:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null},{id:"15",title:"Chemical Biology",coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",isOpenForSubmission:!0,annualVolume:11411,editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",slug:"sukru-beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",biography:"Dr. Şükrü Beydemir obtained a BSc in Chemistry in 1995 from Yüzüncü Yıl University, MSc in Biochemistry in 1998, and PhD in Biochemistry in 2002 from Atatürk University, Turkey. He performed post-doctoral studies at Max-Planck Institute, Germany, and University of Florence, Italy in addition to making several scientific visits abroad. He currently works as a Full Professor of Biochemistry in the Faculty of Pharmacy, Anadolu University, Turkey. Dr. Beydemir has published over a hundred scientific papers spanning protein biochemistry, enzymology and medicinal chemistry, reviews, book chapters and presented several conferences to scientists worldwide. He has received numerous publication awards from various international scientific councils. He serves in the Editorial Board of several international journals. 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He is a member of the Turkish Biochemical Society, American Chemical Society, and German Genetics society. Dr. Ekinci published around ninety scientific papers, reviews and book chapters, and presented several conferences to scientists. He has received numerous publication awards from several scientific councils. 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She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/15648_n.jpg",biography:"Dr. Mohd Aftab Siddiqui is currently working as Assistant Professor in the Faculty of Pharmacy, Integral University, Lucknow for the last 6 years. He has completed his Doctor in Philosophy (Pharmacology) in 2020 from Integral University, Lucknow. He completed his Bachelor in Pharmacy in 2013 and Master in Pharmacy (Pharmacology) in 2015 from Integral University, Lucknow. He is the gold medalist in Bachelor and Master degree. He qualified GPAT -2013, GPAT -2014, and GPAT 2015. His area of research is Pharmacological screening of herbal drugs/ natural products in liver and cardiac diseases. He has guided many M. Pharm. research projects. He has many national and international publications.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. degree from Integral University. Currently, he’s working as an Assistant Professor of Pharmaceutics in the Faculty of Pharmacy, Integral University. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than 32 original articles published in reputed journals, 3 edited books, 5 book chapters, and a number of scientific articles published in ‘Ingredients South Asia Magazine’ and ‘QualPharma Magazine’. He is a member of the American Association for Cancer Research, International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs that aim to provide practical solutions to current healthcare problems.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}},{id:"297507",title:"Dr.",name:"Charles",middleName:"Elias",surname:"Assmann",slug:"charles-assmann",fullName:"Charles Assmann",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/297507/images/system/297507.jpg",biography:"Charles Elias Assmann is a biologist from Federal University of Santa Maria (UFSM, Brazil), who spent some time abroad at the Ludwig-Maximilians-Universität München (LMU, Germany). He has Masters Degree in Biochemistry (UFSM), and is currently a PhD student at Biochemistry at the Department of Biochemistry and Molecular Biology of the UFSM. His areas of expertise include: Biochemistry, Molecular Biology, Enzymology, Genetics and Toxicology. He is currently working on the following subjects: Aluminium toxicity, Neuroinflammation, Oxidative stress and Purinergic system. Since 2011 he has presented more than 80 abstracts in scientific proceedings of national and international meetings. Since 2014, he has published more than 20 peer reviewed papers (including 4 reviews, 3 in Portuguese) and 2 book chapters. He has also been a reviewer of international journals and ad hoc reviewer of scientific committees from Brazilian Universities.",institutionString:"Universidade Federal de Santa Maria",institution:{name:"Universidade Federal de Santa Maria",country:{name:"Brazil"}}},{id:"217850",title:"Dr.",name:"Margarete Dulce",middleName:null,surname:"Bagatini",slug:"margarete-dulce-bagatini",fullName:"Margarete Dulce Bagatini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217850/images/system/217850.jpeg",biography:"Dr. Margarete Dulce Bagatini is an associate professor at the Federal University of Fronteira Sul/Brazil. She has a degree in Pharmacy and a PhD in Biological Sciences: Toxicological Biochemistry. She is a member of the UFFS Research Advisory Committee\nand a member of the Biovitta Research Institute. She is currently:\nthe leader of the research group: Biological and Clinical Studies\nin Human Pathologies, professor of postgraduate program in\nBiochemistry at UFSC and postgraduate program in Science and Food Technology at\nUFFS. She has experience in the area of pharmacy and clinical analysis, acting mainly\non the following topics: oxidative stress, the purinergic system and human pathologies, being a reviewer of several international journals and books.",institutionString:"Universidade Federal da Fronteira Sul",institution:{name:"Universidade Federal da Fronteira Sul",country:{name:"Brazil"}}},{id:"226275",title:"Ph.D.",name:"Metin",middleName:null,surname:"Budak",slug:"metin-budak",fullName:"Metin Budak",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/226275/images/system/226275.jfif",biography:"Metin Budak, MSc, PhD is an Assistant Professor at Trakya University, Faculty of Medicine. He has been Head of the Molecular Research Lab at Prof. Mirko Tos Ear and Hearing Research Center since 2018. His specializations are biophysics, epigenetics, genetics, and methylation mechanisms. He has published around 25 peer-reviewed papers, 2 book chapters, and 28 abstracts. He is a member of the Clinical Research Ethics Committee and Quantification and Consideration Committee of Medicine Faculty. His research area is the role of methylation during gene transcription, chromatin packages DNA within the cell and DNA repair, replication, recombination, and gene transcription. His research focuses on how the cell overcomes chromatin structure and methylation to allow access to the underlying DNA and enable normal cellular function.",institutionString:"Trakya University",institution:{name:"Trakya University",country:{name:"Turkey"}}},{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",slug:"anca-pantea-stoian",fullName:"Anca Pantea Stoian",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",biography:"Anca Pantea Stoian is a specialist in diabetes, nutrition, and metabolic diseases as well as health food hygiene. She also has competency in general ultrasonography.\n\nShe is an associate professor in the Diabetes, Nutrition and Metabolic Diseases Department, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. She has been chief of the Hygiene Department, Faculty of Dentistry, at the same university since 2019. Her interests include micro and macrovascular complications in diabetes and new therapies. Her research activities focus on nutritional intervention in chronic pathology, as well as cardio-renal-metabolic risk assessment, and diabetes in cancer. She is currently engaged in developing new therapies and technological tools for screening, prevention, and patient education in diabetes. \n\nShe is a member of the European Association for the Study of Diabetes, Cardiometabolic Academy, CEDA, Romanian Society of Diabetes, Nutrition and Metabolic Diseases, Romanian Diabetes Federation, and Association for Renal Metabolic and Nutrition studies. She has authored or co-authored 160 papers in national and international peer-reviewed journals.",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",country:{name:"Romania"}}},{id:"279792",title:"Dr.",name:"João",middleName:null,surname:"Cotas",slug:"joao-cotas",fullName:"João Cotas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279792/images/system/279792.jpg",biography:"Graduate and master in Biology from the University of Coimbra.\n\nI am a research fellow at the Macroalgae Laboratory Unit, in the MARE-UC – Marine and Environmental Sciences Centre of the University of Coimbra. My principal function is the collection, extraction and purification of macroalgae compounds, chemical and bioactive characterization of the compounds and algae extracts and development of new methodologies in marine biotechnology area. \nI am associated in two projects: one consists on discovery of natural compounds for oncobiology. The other project is the about the natural compounds/products for agricultural area.\n\nPublications:\nCotas, J.; Figueirinha, A.; Pereira, L.; Batista, T. 2018. An analysis of the effects of salinity on Fucus ceranoides (Ochrophyta, Phaeophyceae), in the Mondego River (Portugal). Journal of Oceanology and Limnology. in press. DOI: 10.1007/s00343-019-8111-3",institutionString:"Faculty of Sciences and Technology of University of Coimbra",institution:null},{id:"279788",title:"Dr.",name:"Leonel",middleName:null,surname:"Pereira",slug:"leonel-pereira",fullName:"Leonel Pereira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/279788/images/system/279788.jpg",biography:"Leonel Pereira has an undergraduate degree in Biology, a Ph.D. in Biology (specialty in Cell Biology), and a Habilitation degree in Biosciences (specialization in Biotechnology) from the Faculty of Science and Technology, University of Coimbra, Portugal, where he is currently a professor. In addition to teaching at this university, he is an integrated researcher at the Marine and Environmental Sciences Center (MARE), Portugal. His interests include marine biodiversity (algae), marine biotechnology (algae bioactive compounds), and marine ecology (environmental assessment). Since 2008, he has been the author and editor of the electronic publication MACOI – Portuguese Seaweeds Website (www.seaweeds.uc.pt). He is also a member of the editorial boards of several scientific journals. Dr. Pereira has edited or authored more than 20 books, 100 journal articles, and 45 book chapters. He has given more than 100 lectures and oral communications at various national and international scientific events. He is the coordinator of several national and international research projects. In 1998, he received the Francisco de Holanda Award (Honorable Mention) and, more recently, the Mar Rei D. Carlos award (18th edition). He is also a winner of the 2016 CHOICE Award for an outstanding academic title for his book Edible Seaweeds of the World. In 2020, Dr. Pereira received an Honorable Mention for the Impact of International Publications from the Web of Science",institutionString:"University of Coimbra",institution:{name:"University of Coimbra",country:{name:"Portugal"}}},{id:"61946",title:"Dr.",name:"Carol",middleName:null,surname:"Bernstein",slug:"carol-bernstein",fullName:"Carol Bernstein",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61946/images/system/61946.jpg",biography:"Carol Bernstein received her PhD in Genetics from the University of California (Davis). She was a faculty member at the University of Arizona College of Medicine for 43 years, retiring in 2011. Her research interests focus on DNA damage and its underlying role in sex, aging and in the early steps of initiation and progression to cancer. In her research, she had used organisms including bacteriophage T4, Neurospora crassa, Schizosaccharomyces pombe and mice, as well as human cells and tissues. She authored or co-authored more than 140 scientific publications, including articles in major peer reviewed journals, book chapters, invited reviews and one book.",institutionString:"University of Arizona",institution:{name:"University of Arizona",country:{name:"United States of America"}}},{id:"182258",title:"Dr.",name:"Ademar",middleName:"Pereira",surname:"Serra",slug:"ademar-serra",fullName:"Ademar Serra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/182258/images/system/182258.jpeg",biography:"Dr. Serra studied Agronomy on Universidade Federal de Mato Grosso do Sul (UFMS) (2005). He received master degree in Agronomy, Crop Science (Soil fertility and plant nutrition) (2007) by Universidade Federal da Grande Dourados (UFGD), and PhD in agronomy (Soil fertility and plant nutrition) (2011) from Universidade Federal da Grande Dourados / Escola Superior de Agricultura Luiz de Queiroz (UFGD/ESALQ-USP). Dr. Serra is currently working at Brazilian Agricultural Research Corporation (EMBRAPA). His research focus is on mineral nutrition of plants, crop science and soil science. Dr. Serra\\'s current projects are soil organic matter, soil phosphorus fractions, compositional nutrient diagnosis (CND) and isometric log ratio (ilr) transformation in compositional data analysis.",institutionString:"Brazilian Agricultural Research Corporation",institution:{name:"Brazilian Agricultural Research Corporation",country:{name:"Brazil"}}}]}},subseries:{item:{id:"12",type:"subseries",title:"Human Physiology",keywords:"Anatomy, Cells, Organs, Systems, Homeostasis, Functions",scope:"Human physiology is the scientific exploration of the various functions (physical, biochemical, and mechanical properties) of humans, their organs, and their constituent cells. The endocrine and nervous systems play important roles in maintaining homeostasis in the human body. Integration, which is the biological basis of physiology, is achieved through communication between the many overlapping functions of the human body's systems, which takes place through electrical and chemical means. Much of the basis of our knowledge of human physiology has been provided by animal experiments. Because of the close relationship between structure and function, studies in human physiology and anatomy seek to understand the mechanisms that help the human body function. The series on human physiology deals with the various mechanisms of interaction between the various organs, nerves, and cells in the human body.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/12.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11408,editor:{id:"195829",title:"Prof.",name:"Kunihiro",middleName:null,surname:"Sakuma",slug:"kunihiro-sakuma",fullName:"Kunihiro Sakuma",profilePictureURL:"https://mts.intechopen.com/storage/users/195829/images/system/195829.jpg",biography:"Professor Kunihiro Sakuma, Ph.D., currently works in the Institute for Liberal Arts at the Tokyo Institute of Technology. He is a physiologist working in the field of skeletal muscle. He was awarded his sports science diploma in 1995 by the University of Tsukuba and began his scientific work at the Department of Physiology, Aichi Human Service Center, focusing on the molecular mechanism of congenital muscular dystrophy and normal muscle regeneration. His interest later turned to the molecular mechanism and attenuating strategy of sarcopenia (age-related muscle atrophy). His opinion is to attenuate sarcopenia by improving autophagic defects using nutrient- and pharmaceutical-based treatments.",institutionString:null,institution:{name:"Tokyo Institute of Technology",institutionURL:null,country:{name:"Japan"}}},editorTwo:null,editorThree:{id:"331519",title:"Dr.",name:"Kotomi",middleName:null,surname:"Sakai",slug:"kotomi-sakai",fullName:"Kotomi Sakai",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000031QtFXQA0/Profile_Picture_1637053227318",biography:"Senior researcher Kotomi Sakai, Ph.D., MPH, works at the Research Organization of Science and Technology in Ritsumeikan University. She is a researcher in the geriatric rehabilitation and public health field. She received Ph.D. from Nihon University and MPH from St.Luke’s International University. Her main research interest is sarcopenia in older adults, especially its association with nutritional status. Additionally, to understand how to maintain and improve physical function in older adults, to conduct studies about the mechanism of sarcopenia and determine when possible interventions are needed.",institutionString:null,institution:{name:"Ritsumeikan University",institutionURL:null,country:{name:"Japan"}}},series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"213786",title:"Dr.",name:"Henrique P.",middleName:null,surname:"Neiva",slug:"henrique-p.-neiva",fullName:"Henrique P. 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Shaaban and Amr Farouk",slug:"encapsulation-of-essential-oils-and-their-use-in-food-applications",totalDownloads:50,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"80959",title:"Biological Application of Essential Oils and Essential Oils Components in Terms of Antioxidant Activity and Inhibition of Cholinesterase Enzymes",doi:"10.5772/intechopen.102874",signatures:"Mejra Bektašević and Olivera Politeo",slug:"biological-application-of-essential-oils-and-essential-oils-components-in-terms-of-antioxidant-activ",totalDownloads:48,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"80859",title:"Antioxidant Effect and Medicinal Properties of Allspice Essential Oil",doi:"10.5772/intechopen.103001",signatures:"Yasvet Yareni Andrade Avila, Julián Cruz-Olivares and César Pérez-Alonso",slug:"antioxidant-effect-and-medicinal-properties-of-allspice-essential-oil",totalDownloads:34,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Essential Oils - Advances in Extractions and Biological Applications",coverURL:"https://cdn.intechopen.com/books/images_new/11332.jpg",subseries:{id:"15",title:"Chemical Biology"}}},{id:"80777",title:"Starch: A Veritable Natural Polymer for Economic Revolution",doi:"10.5772/intechopen.102941",signatures:"Obi P. 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