\r\n\tFrom practice to a mathematical and technological application, scheduling has become another form of art: an algorithmic art, declined in as many OS and hardware constraints, from embedded systems onboard an aircraft or a spacecraft to databases in all financial and Internet servers.
\r\n\tThey have become ubiquitous so that a large part of our civilisational development is supported by their reliability, redundancy, and optimisation capacity. Like all of our civilisational assets, they are benefiting from scientific breakthrough in computational sciences such as evolutionary algorithms, Artificial Intelligence, and quantum computing. If not by using it, by being in need of adapting to the next generation of computing. Space development is also bringing new challenges, especially in redundancy and reliability.
Acute hydrops is a well-known complication of progressive keratoconus. It has also been reported in other noninflammatory ectatic disorders such as pellucid marginal degeneration and keratoglobus. The incidence of acute hydrops is minimal but varies according to race. A 2011 UK census reported higher number of cases among the South Asian and Black ethnic groups, compared with that in the general population. The reported incidence rates among the white, South Asian, and black population are 0.07/100,000, 0.32 /100,000, and 0.37/100,000, respectively [1]. According to numerous studies, the trend in acute hydrops Incidence among patients with keratoconus has been shown to be decreasing; Tuft et al. and Amsler M et al. reported the prevalence of acute hydrops as 2.6% and 2.8%, respectively [2, 3]. Acute hydrops can occur at any age but is commonly reported in individuals aged between 20 and 30 years, whereas the broad age range is 10 to 47 years. It has a significant gender disparity; men are more susceptible to this condition compared with women, with a ratio of 1.2:1 according to the Auckland Keratoconus Study [4], 3:1 according to a UK prospective study [1], and 2.9:1 according to an American study [5].
Ocular allergy is frequently associated with keratoconus ranging from 7 to 35% [6, 7, 8, 9]. Bawazeer et al. in a case control study demonstrated a positive correlation between keratoconus and atopy [10]. Any form of ocular allergy instigates itching, foreign body sensation, and eye rubbing [11]. This triggers a corneal intrastromal inflammation because of the increased levels of histamine, tumor necrosis factor-alpha, and interleukins [12]. It coaxes to stromal lysis and corneal thinning because of the increased levels of lysosomal and proteolytic enzymes with a simultaneous reduction in the levels of protease inhibitors [12]. This vicious cycle of inflammation and stromal lysis is exacerbated by recurrent eye rubbing [13], and the stable keratoconus eventually becomes progressive which increases the risk of acute hydrops [14].
A history of having worn the contact lenses, specially the rigid gas permeable lens, is also considered an important risk factor for acute hydrops [15]. Contact lens usage triggers ocular inflammation because of hypoxia of the corneal surface [16]. A study showed that the level of inflammatory markers present in the tear film increases after the use of contact lens [17]. This inflammation initiates the progression of keratoconus that eventually leads to acute hydrops [18].
A trivial ocular trauma plays a significant role in the rupturing of already stressed-out descemet membrane (DM) [19]. Advanced keratoconus, eccentric cone, and poor visual acuity are other important risk factors for acute hydrops in patients with keratoconus. Down syndrome increases the risk of keratoconus progression, thereby increasing the risk of acute hydrops [20]. Retinitis pigmentosa, Leber Congenital Amaurosis (LCA), floppy eye lid syndrome, and Ehler-Danlos syndrome are other risk factors for progressive keratoconus, which are followed by the incident of hydrops [21, 22, 23, 24]. Pregnancy and lactation are also the critical but temporary risk factors [25]. However, a positive family history has been reported to have a negative correlation with the acute hydrops incidence [26].
Corneal topography plays a critical role in identifying patients with keratoconus progression [27]. Various parameters are available in pentacam that must be reinvestigated after every 3 month to accurately diagnose the progression; parameters, namely, maximum keratometry, minimum pachymetry, pachymetric progression index, elevation indices of corneal front and back surfaces, anterior radius of curvature taken 3 mm surrounding the thinnest pachymetry, posterior radius of curvature taken 3 mm surrounding the thinnest pachymetry, and deviation index, must be scrutinized during every visit. Any evidence of progression should be intervened to prevent or halt the deterioration to eventually decrease the risk of acute hydrops incidence [28].
The progression of keratoconus initiates because of stretching of the DM that is adhered strongly to the periphery, which leads to circumferential stretching of the membrane and increased risk of its rupture [29, 30]. If the stretching extends beyond a limit, the membrane tends to rupture at the center, which leads to the seepage of aqueous fluid into the stroma and thereby causes acute hydrops [31].
Acute hydrops initiates with a sudden onset of poor vision and discoloration of the cornea [32]. The disease is confined to the central and paracentral regions and rarely manifests in the peripheral region in case of coexistent pellucid marginal degeneration [33]. In addition to a defective vision, pain and redness are the typical symptoms of this disease [34]. The patients exhibit a definite history of persisting poor vision since childhood and experience progressive vision loss [35]. History of spectacle use should be investigated by reviewing the old optical prescriptions or old spectacles. Past history of high astigmatism, oblique axis and poor best corrected visual acuity are considered as corroborative clinical signs of acute hydrops following progressive keratoconus. Meticulous medical history of ocular allergy, atopic dermatitis, contact lens usage, eye rubbing, and ocular trauma should be documented [36]. Contact lens history, with emphasis on the type, duration of usage, overnight usage while sleeping, and expiry date of the contact lens, is also considered essential [37]. Ocular trauma history, with emphasis on the blunt trauma not withstanding its impact or severity, should also be documented (Figure 1) [38].
Examination using a diffused torchlight reveals a whitish lesion over the central or paracentral regions with intense photophobia (Figure 1). Conjunctiva shows a sign of circumciliary congestion, and palpebral conjunctiva may be congested depending upon the presence of allergic conjunctivitis. In the absence of oculi allergy, eyes are less susceptible to palpebral congestion. The iris or anterior segment is not visible in case of central hydrops but in cases of paracentral hydrops, the anterior segment is clearly visible through the clear cornea [35].
Showing a case of acute hydrops.
Slit lamp examination with an oblique slit shows an abnormally thick cornea with clefts in the intrastromal area and Obscuration of Descemet Membrane (DM) due to the blockage of light rays by the edematous cornea [39, 40].
Acute hydrops can be graded depending on the corneal region involved. Corneal edema can be graded by drawing an imaginary circle around the cornea [41].
Grade 1: Involves 3-mm diameter of cornea.
Grade 2: Between 3- and 5-mm diameter of cornea.
Grade 3: More than 5 m-diameter of cornea.
Though acute hydrops is mostly diagnosed clinically, anterior segment OCT (ASOCT) can be performed to assess the severity and pattern of the resolution (Figure 2), [42]. ASOCT manifests as hypo reflective areas in the presence of fluid, hyper-reflective areas in the presence of fibrous tissues. In the early phase of corneal edema, epithelial micro cysts with pseudocysts formation in the intrastromal area are witnessed as hyporeflective areas [43]. Pseudocysts develop due to fluid accumulation in the intrastromal spaces separating the stromal lamellae because of the sudden egress of the fluid. The word “pseudocyst” was coined because the cyst wall formation does not involve epithelium. These pseudocysts are initially small in size and multiple in number but eventually they fuse to become a large cyst [44]. Sometimes, the fluid reaches the anterior stroma leading to bullous swelling of the corneal surface, referred as “epitheliocoele” in literature [45]. High-resolution ASOCT can demonstrate a breach in the continuity of the DM and stromal access to the aqueous humor [46]. ASOCT can also demonstrate a slow healing process of polygonal defects in the DM that is caused by its rupture. Healing of DM takes place slowly than that of the corneal epithelium. Hence, decrease in the size of DM defect can be witnessed after a week, and in the due course, the corneal edema which is seen as hypo-reflective/dark areas gets reduced eventually allowing the visibility of hyper-reflective shadows in the sub epithelial area marks the healing of acute hydrops [46].
ASOCT showing corneal edema, clefts and cysts (courtesy-Dr.Sridevi Gunda).
Confocal microscopy is a new modality in the investigation process; though it is more useful for academic purpose, it gives an insight into the pathology of the disease [47]. Confocal microscope acts like an in vivo electron microscope; hence, the technique is termed as in vivo confocal microscopy (IVCM). It analyses the anterior and middle parts of the cornea. Bullae are seen in the superficial and wing layers of the corneal epithelium. Stromal area shows hyper-reflective band-shaped structures in the anterior stroma, and microfilms are seen in the mid and anterior stroma. Hyper-reflective cells are seen in the anterior stroma and epithelium, which are presumed to be inflammatory cells [48].
Acute hydrops commonly resolves spontaneously over a period of 4–8 weeks; however, it can be delayed because of large DM deficit or poor functionality of the corneal endothelial cells [49].
The risk of corneal perforation in cases of extreme penetration of fluid into the anterior stromal space is also present, which results in the formation of the epithelial bullae [50]. Any trivial trauma or ocular rubbing causes the rupture of the bullae, which may lead to shallowing of an anterior chamber and the formation of an anterior synechiae. Upon healing, it forms a dense vascularized corneal scar with extremely poor prognosis [51].
Corneal vascularization can be accentuated with a delay in the process of corneal edema reduction. Long-term cornea edema is associated with a risk of the release of vascular endothelial growth factors that induces corneal vasculogenesis from the peripheral corneal vessels, eventually leading to the formation of a vascularized corneal scar [51].
Bullous rupture of the corneal surface exposes raw stroma to the tear film and ocular commensals. Poor hygienic practices may lead to infectious keratitis [52]. Mostly bacterial keratitis has been reported; however, fungal keratitis has also been reported in the tropical countries. In developing countries such as India, the use of over-the-counter topical corticosteroids without clinical consultation is rampant that has led to the development of debilitating infectious keratitis [53].
Penetrating ocular trauma may mimic acute hydrops; however, it has a recent background history of trauma and entry wound [54].
Calotropis keratitis commonly seen in the Indian subcontinent seen after accidental fall of whitish fluid while plucking the flower of the plant [55]. It may be localized or diffused and mostly presents as emergency having a perfectly normal vision before the fall. Upon slit lamp examination, a typical DM folds with the corneal edema are visible, and no breach in the continuity of DM is detected.
Post-herpetic endothelial dysfunctions are seen typically after an episode of herpetic keratitis or most likely after herpes zoster ophthalmicus. Clinically, it is seen as the localized corneal edema with pigment dusting of the endothelium and the presence of sectoral iris atrophy in case of herpes zoster [56, 57].
CMV keratitis is another rarely seen condition of the cornea that can be considered for the differential diagnosis of acute hydrops, and it typically manifests as a focal corneal edema and appears as a coin-shaped lesion [58].
Nuclear fragment retention after cataract surgery is a rare but a significant differential diagnosis, which manifests as on- and off-focal corneal edema mostly in the inferior quadrant. A careful clinical examination of an anterior segment reveals the presence of nuclear fragments and a positive history of recurrent anterior uveitis [59].
Bullous keratopathy due to Fuchs endothelial corneal dystrophy can be ruled out by seeing the other eye [60].
Medical management is mostly supportive and not definitive [61]. Pressure bandages may be helpful in reducing the corneal edema; however, it increases the risk of bullous rupture with vascularized corneal scar. A study reported that the use of bandage contact lens decreases the corneal edema but increases the corneal hypoxia, which delays the process of corneal healing and causes dense scar [62]. Topical hypertonic saline (5%) eye drops are used to treat acute corneal edema to enhance dryness of the cornea, and these eye drops work by pulling the water out of the cornea thorough an osmotic pattern. Additionally, the risk of epithelial breakage is decreased, which in turn decreases the risk of secondary infection. However, the patients experience a severe burning sensation and discomfort after using the eye drop. Hence, the efficacy of these eye drops is questionable. Topical corticosteroid eye drops can be used to decrease the inflammation and improve the endothelial functioning. These may also decrease the corneal neovascularization and symptomatic ocular discomfort. However, the topical corticosteroid eye drop usage is associated with an increased risk of steroid-induced glaucoma, cataract, and infectious keratitis over the ruptured bullae. Hence, it should be used cautiously with close follow-ups [61].
Various modalities of surgical management have been mentioned in literature to augment the process of corneal healing. All the methods mentioned in literature are equally efficient, providing a favorable visual outcome and preventing the formation of the corneal vascularization.
Primary surgical intention for acute hydrops is not to restore or confer a normal vision but hasten the resolution of corneal edema which eventually leads to a non-vascularised scar improving the prognosis for corneal transplantation.
Surgical modalities are as follows:
Intracameral gas
Combination of compressive sutures and intracameral gas (Figure 5)
Deep anterior lamellar keratoplasty (DALK)
Mini Descemet membrane endothelial keratoplasty (mini-DMEK)
Showing resolution of corneal edema after application of compressive sutures.
Complete resolution of corneal edema with clear visualization of anterior segment structures.
Combination of compressive sutures with intracameral SF6 gas (Dr.Devi Aiswarya Das).
It is considered a treatment of choice for acute hydrops. Gas or air in an anterior chamber has 2 distinct advantages: first, it aids in the unrolling of the DM, and second, it provides compression of the DM to the swollen stroma [63, 64]. An injection of air was tried but it got absorbed in 3 days without giving enough tamponade to the DM. Hence, a nonexpansile mixture of the expansile gas with air is used to maintain the tamponade effect for a minimum period of 10 days. Sulfur hexafluoride (SF6) and perfluoropropane (C3F8) are commonly used by the corneal surgeons worldwide to produce a prolonged tamponade effect. SF6 (0.1 mL, 20%) was used by Panda et al. in their study of 9 cases that showed only marginal improvement in 3 cases and the remaining 6 cases required reintroduction of the gas twice or more for complete resolution of the corneal edema [63]. Basu et al. performed a comparative study on patients with acute hydrops [64]. One arm of the patients was treated with 14% nonexpansile perfluoropropane (C3F8), wheras the other arm was treated with conventional medical therapy. A faster resolution of the corneal edema was observed in the eyes of patients who were surgically treated, and the improvement was statistically significant. All the patients were advised to rest in a supine position for a period of 10 days to augment the tamponade effect. Histopathological studies on resolved hydrops have confirmed that DM adherence to the stroma is superior with intracameral gas compared with that without any treatment. All authors in the referred studies have recommended the continuation of conventional medical therapy of hypertonic saline eye drops, corticosteroids, and antiglaucoma drugs in the postoperative period. Nevertheless, acute hydrops treated using intracameral gas poses a high risk of pupillary block glaucoma, Urrets-Zavala syndrome, stromal cleft, and accidental seepage of air bubbles into the cornea stroma resembles a ‘fish egg’ in appearance in a slit lamp experiment. Hence, an inferior surgical iridectomy is recommended to prevent any instances of acute congestive glaucoma. Moreover, the intracameral gas should be introduced along the iris plane and in a single bubble because faulty introduction of the gas may lead to the bursting of the bubble into multiple bubbles that will nullify the tamponade effect and cause accidental damage to the corneal endothelium and seepage of the bubbles into the stroma.
Full-thickness corneal sutures involving the edematous part of the cornea have facilitated decrease in the corneal edema [30]. Here a 10–0 nylon suture is used to tamponade the Descemet membrane to corneal stroma. Initially a small paracentesis is created at the limbus of cornea followed by injection of intracameral pilocarpine to constrict the pupil. Viscoelastics are injected into the anterior chamber next to protect iris and crystalline lens. A 10–0 nylon suture is introduced at the junction of edematous and non-edematous cornea, the curved needle once enters the anterior chamber is taken out from the farthest end of the needle with a distance equivalent to the length of the needle and is tied over the corneal surface. The knot of a suture is buried into the cornea. Multiple sutures can be applied depending on the extent of the edema. The basic purpose of compressive sutures is not to oppose the torn DM ends but just to provide a support to the DM by bringing it near to the stroma. Once DM is opposed to the stromal endothelial cells, it starts pumping out a fluid from the stroma by active filtration and thereby helps in faster resolution of the corneal edema. Subudhi et al. demonstrated an excellent visual outcome associated with the use of compressive sutures alone in the management of acute hydrops; visual acuity of the patient improved from hand movements to 6/24 by the end of 2 months with a minimal scar at the center and no evidence of any corneal vascularization. Compressive sutures can be applied in a linear manner in case of small hydrops, but if hydrops is large enough to cover nearly all portions of the cornea, then a rectangular pattern involving all the quadrants can be applied. Pads and bandages can be given for a period of 24 hours to prevent any egress of fluid from the anterior chamber and its shallowing. Intracameral antibiotics can be given as prophylactic measures. These sutures stay for a period of 2 to 3 weeks; loosening of the sutures causes loss in the tamponade effect and should be removed in an operating room under strict aseptic precautions. Adverse effects observed are the shallow anterior chamber on Post-Operative Day 1; however, they got resolved in 24 hours without any further intervention. Nonetheless, these patients were advised to perform their routine activity after 5 days of rest. No patients were advised to have a mandatory supine position as in the treatment with intracameral gas injection.
In a view of complications associated with the single use of the intracameral gas or compressive sutures, Rajaraman and associates suggested a combination of compressive sutures and intracameral gas to incorporate the advantages of both the procedures [64]. Compressive sutures prevent the seepage of air bubbles into the intrastromal space and the intracameral gas prevents the shallowing of the anterior chamber in an immediate postoperative period following the application of the full-thickness compressive sutures.
In this procedure paracentesis is done to reduce the intraocular pressure so that the tension of aqueous humor over Descemet membrane is eliminated subsequently thermokeratoplasty is done to induce stromal contraction thus outward expansion of stroma due to edematous cornea is reduced. Hence eventually hastening the resolution of acute hydrops [65].
Anterior lamellar keratoplasty [66] in the pretext of acute hydrops is a difficult and complex procedure. Susan et al. recommended a modified DALK method for the treatment of acute hydrops. Small aliquots of air are injected into the stroma, immediately above the predescemeticdua layer and away from the site of the descemet rupture. Subsequently, a lamellar dissection with the help of a blunt crescent is performed carefully in the peripheral cornea, while avoiding the site of the DM tear initially, and then dissected at the center by slowly peeling the stroma. A donor cornea of the same size or 0.25 mm oversize is placed over the raw recipient corneal surface and anchored with the help of twelve or sixteen 10–0 nylon sutures. This averts the two-step procedure, which is normally adopted for acute hydrops, and thus, the visual rehabilitation is gained with a single procedure. However, because of edematous cornea, the risk of augmentation of the DM tear is increased and locating a correct plane for dissection becomes difficult for the surgeons. Therefore, surgeons are advised to become well-versed with anterior lamellar keratoplasty before advocating this procedure.
It is another [67] procedure described in literature. Bachmann and associates described a novel technique of replacing the torn DM with a well-circumscribed donor DM. In this technique, the peripheral torn DM is trimmed and stripped up to the center of the cornea. But the crux of the matter here is that all the maneuvers are performed with an intraoperative OCT-enabled microscope. The donor DM is prepared depending on the defect and is introduced into the anterior chamber with the help of the lens cartridge. Rolled DM enters into the anterior chamber and is unrolled with the help of 2 Sinskey hooks by pressing one end and ironing the other end of corneal lenticule over the anterior corneal surface. Determination of the correct orientation of the lenticule in the anterior chamber is essential for surgeons, which is not possible with a routine microscope because the visibility of the anterior chamber remains poor. With the dense corneal edema, this procedure is highly inappropriate in the routine clinical settings. Hence, approaching through the anterior surface of cornea rather than posterior corneal surface is preferable.
Management of acute hydrops influences a long-term visual outcome. ASOCT provides a superior insight into the pathogenesis of acute hydrops. An early intervention is essential for preventing the vascularization of the corneal scar and eventually improving the prognosis of penetrating keratoplasty. Compression sutures, intra cameral gas, and a combination of both are efficient techniques described in the literature with a proven efficacy in hastening the resolution of the corneal edema. DALK and mini-DMEK are highly skillful procedures with questionable reproducibility by multiple surgeons. Prevention of acute hydrops should be a primary goal of all corneal surgeons in the future. An early identification and management of progressive keratoconus, prevention of eye rubbing, and avoidance of the professional sports may decrease the incidence of acute hydrops.
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In 2021 he has been awarded the “Raul Isturiz Award” Medal of the API. Also, in 2021, he was awarded with the “Jose Felix Patiño” Asclepius Staff Medal of the Colombian Medical College, due to his scientific contributions to COVID-19 during the pandemic. He is currently the Editor in Chief of the journal Travel Medicine and Infectious Diseases. His Scopus H index is 47 (Google Scholar H index, 68).",institutionString:"Institución Universitaria Visión de las Américas, Colombia",institution:null},{id:"332819",title:"Dr.",name:"Chukwudi Michael",middleName:"Michael",surname:"Egbuche",slug:"chukwudi-michael-egbuche",fullName:"Chukwudi Michael Egbuche",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/332819/images/14624_n.jpg",biography:"I an Dr. Chukwudi Michael Egbuche. I am a Senior Lecturer in the Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka.",institutionString:null,institution:{name:"Nnamdi Azikiwe University",country:{name:"Nigeria"}}},{id:"284232",title:"Mr.",name:"Nikunj",middleName:"U",surname:"Tandel",slug:"nikunj-tandel",fullName:"Nikunj Tandel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284232/images/8275_n.jpg",biography:'Mr. Nikunj Tandel has completed his Master\'s degree in Biotechnology from VIT University, India in the year of 2012. He is having 8 years of research experience especially in the field of malaria epidemiology, immunology, and nanoparticle-based drug delivery system against the infectious diseases, autoimmune disorders and cancer. He has worked for the NIH funded-International Center of Excellence in Malaria Research project "Center for the study of complex malaria in India (CSCMi)" in collaboration with New York University. The preliminary objectives of the study are to understand and develop the evidence-based tools and interventions for the control and prevention of malaria in different sites of the INDIA. Alongside, with the help of next-generation genomics study, the team has studied the antimalarial drug resistance in India. Further, he has extended his research in the development of Humanized mice for the study of liver-stage malaria and identification of molecular marker(s) for the Artemisinin resistance. At present, his research focuses on understanding the role of B cells in the activation of CD8+ T cells in malaria. Received the CSIR-SRF (Senior Research Fellow) award-2018, FIMSA (Federation of Immunological Societies of Asia-Oceania) Travel Bursary award to attend the IUIS-IIS-FIMSA Immunology course-2019',institutionString:"Nirma University",institution:{name:"Nirma University",country:{name:"India"}}},{id:"334383",title:"Ph.D.",name:"Simone",middleName:"Ulrich",surname:"Ulrich Picoli",slug:"simone-ulrich-picoli",fullName:"Simone Ulrich Picoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334383/images/15919_n.jpg",biography:"Graduated in Pharmacy from Universidade Luterana do Brasil (1999), Master in Agricultural and Environmental Microbiology from Federal University of Rio Grande do Sul (2002), Specialization in Clinical Microbiology from Universidade de São Paulo, USP (2007) and PhD in Sciences in Gastroenterology and Hepatology (2012). She is currently an Adjunct Professor at Feevale University in Medicine and Biomedicine courses and a permanent professor of the Academic Master\\'s Degree in Virology. She has experience in the field of Microbiology, with an emphasis on Bacteriology, working mainly on the following topics: bacteriophages, bacterial resistance, clinical microbiology and food microbiology.",institutionString:null,institution:{name:"Universidade Feevale",country:{name:"Brazil"}}},{id:"229220",title:"Dr.",name:"Amjad",middleName:"Islam",surname:"Aqib",slug:"amjad-aqib",fullName:"Amjad Aqib",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229220/images/system/229220.png",biography:"Dr. Amjad Islam Aqib obtained a DVM and MSc (Hons) from University of Agriculture Faisalabad (UAF), Pakistan, and a PhD from the University of Veterinary and Animal Sciences Lahore, Pakistan. Dr. Aqib joined the Department of Clinical Medicine and Surgery at UAF for one year as an assistant professor where he developed a research laboratory designated for pathogenic bacteria. Since 2018, he has been Assistant Professor/Officer in-charge, Department of Medicine, Manager Research Operations and Development-ORIC, and President One Health Club at Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan. He has nearly 100 publications to his credit. His research interests include epidemiological patterns and molecular analysis of antimicrobial resistance and modulation and vaccine development against animal pathogens of public health concern.",institutionString:"Cholistan University of Veterinary and Animal Sciences",institution:null},{id:"62900",title:"Prof.",name:"Fethi",middleName:null,surname:"Derbel",slug:"fethi-derbel",fullName:"Fethi Derbel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/62900/images/system/62900.jpeg",biography:"Professor Fethi Derbel was born in 1960 in Tunisia. He received his medical degree from the Sousse Faculty of Medicine at Sousse, University of Sousse, Tunisia. He completed his surgical residency in General Surgery at the University Hospital Farhat Hached of Sousse and was a member of the Unit of Liver Transplantation in the University of Rennes, France. He then worked in the Department of Surgery at the Sahloul University Hospital in Sousse. Professor Derbel is presently working at the Clinique les Oliviers, Sousse, Tunisia. His hospital activities are mostly concerned with laparoscopic, colorectal, pancreatic, hepatobiliary, and gastric surgery. He is also very interested in hernia surgery and performs ventral hernia repairs and inguinal hernia repairs. He has been a member of the GREPA and Tunisian Hernia Society (THS). During his residency, he managed patients suffering from diabetic foot, and he was very interested in this pathology. For this reason, he decided to coordinate a book project dealing with the diabetic foot. Professor Derbel has published many articles in journals and collaborates intensively with IntechOpen Access Publisher as an editor.",institutionString:"Clinique les Oliviers",institution:null},{id:"300144",title:"Dr.",name:"Meriem",middleName:null,surname:"Braiki",slug:"meriem-braiki",fullName:"Meriem Braiki",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/300144/images/system/300144.jpg",biography:"Dr. Meriem Braiki is a specialist in pediatric surgeon from Tunisia. She was born in 1985. She received her medical degree from the University of Medicine at Sousse, Tunisia. She achieved her surgical residency training periods in Pediatric Surgery departments at University Hospitals in Monastir, Tunis and France.\r\nShe is currently working at the Pediatric surgery department, Sidi Bouzid Hospital, Tunisia. Her hospital activities are mostly concerned with laparoscopic, parietal, urological and digestive surgery. She has published several articles in diffrent journals.",institutionString:"Sidi Bouzid Regional Hospital",institution:null},{id:"229481",title:"Dr.",name:"Erika M.",middleName:"Martins",surname:"de Carvalho",slug:"erika-m.-de-carvalho",fullName:"Erika M. de Carvalho",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/229481/images/6397_n.jpg",biography:null,institutionString:null,institution:{name:"Oswaldo Cruz Foundation",country:{name:"Brazil"}}},{id:"186537",title:"Prof.",name:"Tonay",middleName:null,surname:"Inceboz",slug:"tonay-inceboz",fullName:"Tonay Inceboz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/186537/images/system/186537.jfif",biography:"I was graduated from Ege University of Medical Faculty (Turkey) in 1988 and completed his Med. PhD degree in Medical Parasitology at the same university. I became an Associate Professor in 2008 and Professor in 2014. I am currently working as a Professor at the Department of Medical Parasitology at Dokuz Eylul University, Izmir, Turkey.\n\nI have given many lectures, presentations in different academic meetings. I have more than 60 articles in peer-reviewed journals, 18 book chapters, 1 book editorship.\n\nMy research interests are Echinococcus granulosus, Echinococcus multilocularis (diagnosis, life cycle, in vitro and in vivo cultivation), and Trichomonas vaginalis (diagnosis, PCR, and in vitro cultivation).",institutionString:"Dokuz Eylül University",institution:{name:"Dokuz Eylül University",country:{name:"Turkey"}}},{id:"71812",title:"Prof.",name:"Hanem Fathy",middleName:"Fathy",surname:"Khater",slug:"hanem-fathy-khater",fullName:"Hanem Fathy Khater",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/71812/images/1167_n.jpg",biography:"Prof. Khater is a Professor of Parasitology at Benha University, Egypt. She studied for her doctoral degree, at the Department of Entomology, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, USA. She has completed her Ph.D. degrees in Parasitology in Egypt, from where she got the award for “the best scientific Ph.D. dissertation”. She worked at the School of Biological Sciences, Bristol, England, the UK in controlling insects of medical and veterinary importance as a grant from Newton Mosharafa, the British Council. Her research is focused on searching of pesticides against mosquitoes, house flies, lice, green bottle fly, camel nasal botfly, soft and hard ticks, mites, and the diamondback moth as well as control of several parasites using safe and natural materials to avoid drug resistances and environmental contamination.",institutionString:null,institution:{name:"Banha University",country:{name:"Egypt"}}},{id:"99780",title:"Prof.",name:"Omolade",middleName:"Olayinka",surname:"Okwa",slug:"omolade-okwa",fullName:"Omolade Okwa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/99780/images/system/99780.jpg",biography:"Omolade Olayinka Okwa is presently a Professor of Parasitology at Lagos State University, Nigeria. She has a PhD in Parasitology (1997), an MSc in Cellular Parasitology (1992), and a BSc (Hons) Zoology (1990) all from the University of Ibadan, Nigeria. She teaches parasitology at the undergraduate and postgraduate levels. She was a recipient of a Commonwealth fellowship supported by British Council tenable at the Centre for Entomology and Parasitology (CAEP), Keele University, United Kingdom between 2004 and 2005. She was awarded an Honorary Visiting Research Fellow at the same university from 2005 to 2007. \nShe has been an external examiner to the Department of Veterinary Microbiology and Parasitology, University of Ibadan, MSc programme between 2010 and 2012. She is a member of the Nigerian Society of Experimental Biology (NISEB), Parasitology and Public Health Society of Nigeria (PPSN), Science Association of Nigeria (SAN), Zoological Society of Nigeria (ZSN), and is Vice Chairperson of the Organisation of Women in Science (OWSG), LASU chapter. She served as Head of Department of Zoology and Environmental Biology, Lagos State University from 2007 to 2010 and 2014 to 2016. She is a reviewer for several local and international journals such as Unilag Journal of Science, Libyan Journal of Medicine, Journal of Medicine and Medical Sciences, and Annual Research and Review in Science. \nShe has authored 45 scientific research publications in local and international journals, 8 scientific reviews, 4 books, and 3 book chapters, which includes the books “Malaria Parasites” and “Malaria” which are IntechOpen access publications.",institutionString:"Lagos State University",institution:{name:"Lagos State University",country:{name:"Nigeria"}}},{id:"273100",title:"Dr.",name:"Vijay",middleName:null,surname:"Gayam",slug:"vijay-gayam",fullName:"Vijay Gayam",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/273100/images/system/273100.jpeg",biography:"Dr. Vijay Bhaskar Reddy Gayam is currently practicing as an internist at Interfaith Medical Center in Brooklyn, New York, USA. He is also a Clinical Assistant Professor at the SUNY Downstate University Hospital and Adjunct Professor of Medicine at the American University of Antigua. He is a holder of an M.B.B.S. degree bestowed to him by Osmania Medical College and received his M.D. at Interfaith Medical Center. His career goals thus far have heavily focused on direct patient care, medical education, and clinical research. He currently serves in two leadership capacities; Assistant Program Director of Medicine at Interfaith Medical Center and as a Councilor for the American\r\nFederation for Medical Research. As a true academician and researcher, he has more than 50 papers indexed in international peer-reviewed journals. He has also presented numerous papers in multiple national and international scientific conferences. His areas of research interest include general internal medicine, gastroenterology and hepatology. He serves as an editor, editorial board member and reviewer for multiple international journals. His research on Hepatitis C has been very successful and has led to multiple research awards, including the 'Equity in Prevention and Treatment Award” from the New York Department of Health Viral Hepatitis Symposium (2018) and the 'Presidential Poster Award” awarded to him by the American College of Gastroenterology (2018). He was also awarded 'Outstanding Clinician in General Medicine” by Venus International Foundation for his extensive research expertise and services, perform over and above the standard expected in the advancement of healthcare, patient safety and quality of care.",institutionString:"Interfaith Medical Center",institution:{name:"Interfaith Medical Center",country:{name:"United States of America"}}},{id:"93517",title:"Dr.",name:"Clement",middleName:"Adebajo",surname:"Meseko",slug:"clement-meseko",fullName:"Clement Meseko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/93517/images/system/93517.jpg",biography:"Dr. Clement Meseko obtained DVM and PhD degree in Veterinary Medicine and Virology respectively. He has worked for over 20 years in both private and public sectors including the academia, contributing to knowledge and control of infectious disease. Through the application of epidemiological skill, classical and molecular virological skills, he investigates viruses of economic and public health importance for the mitigation of the negative impact on people, animal and the environment in the context of Onehealth. \r\nDr. Meseko’s field experience on animal and zoonotic diseases and pathogen dynamics at the human-animal interface over the years shaped his carrier in research and scientific inquiries. He has been part of the investigation of Highly Pathogenic Avian Influenza incursions in sub Saharan Africa and monitors swine Influenza (Pandemic influenza Virus) agro-ecology and potential for interspecies transmission. He has authored and reviewed a number of journal articles and book chapters.",institutionString:"National Veterinary Research Institute",institution:{name:"National Veterinary Research Institute",country:{name:"Nigeria"}}},{id:"158026",title:"Prof.",name:"Shailendra K.",middleName:null,surname:"Saxena",slug:"shailendra-k.-saxena",fullName:"Shailendra K. Saxena",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",biography:"Professor Dr. Shailendra K. Saxena is a vice dean and professor at King George's Medical University, Lucknow, India. His research interests involve understanding the molecular mechanisms of host defense during human viral infections and developing new predictive, preventive, and therapeutic strategies for them using Japanese encephalitis virus (JEV), HIV, and emerging viruses as a model via stem cell and cell culture technologies. His research work has been published in various high-impact factor journals (Science, PNAS, Nature Medicine) with a high number of citations. He has received many awards and honors in India and abroad including various Young Scientist Awards, BBSRC India Partnering Award, and Dr. JC Bose National Award of Department of Biotechnology, Min. of Science and Technology, Govt. of India. Dr. Saxena is a fellow of various international societies/academies including the Royal College of Pathologists, United Kingdom; Royal Society of Medicine, London; Royal Society of Biology, United Kingdom; Royal Society of Chemistry, London; and Academy of Translational Medicine Professionals, Austria. He was named a Global Leader in Science by The Scientist. He is also an international opinion leader/expert in vaccination for Japanese encephalitis by IPIC (UK).",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",country:{name:"India"}}},{id:"94928",title:"Dr.",name:"Takuo",middleName:null,surname:"Mizukami",slug:"takuo-mizukami",fullName:"Takuo Mizukami",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94928/images/6402_n.jpg",biography:null,institutionString:null,institution:{name:"National Institute of Infectious Diseases",country:{name:"Japan"}}},{id:"233433",title:"Dr.",name:"Yulia",middleName:null,surname:"Desheva",slug:"yulia-desheva",fullName:"Yulia Desheva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/233433/images/system/233433.png",biography:"Dr. Yulia Desheva is a leading researcher at the Institute of Experimental Medicine, St. Petersburg, Russia. She is a professor in the Stomatology Faculty, St. Petersburg State University. She has expertise in the development and evaluation of a wide range of live mucosal vaccines against influenza and bacterial complications. Her research interests include immunity against influenza and COVID-19 and the development of immunization schemes for high-risk individuals.",institutionString:'Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"',institution:null},{id:"238958",title:"Mr.",name:"Atamjit",middleName:null,surname:"Singh",slug:"atamjit-singh",fullName:"Atamjit Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/238958/images/6575_n.jpg",biography:null,institutionString:null,institution:null},{id:"333753",title:"Dr.",name:"Rais",middleName:null,surname:"Ahmed",slug:"rais-ahmed",fullName:"Rais Ahmed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333753/images/20168_n.jpg",biography:null,institutionString:null,institution:null},{id:"252058",title:"M.Sc.",name:"Juan",middleName:null,surname:"Sulca",slug:"juan-sulca",fullName:"Juan Sulca",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252058/images/12834_n.jpg",biography:null,institutionString:null,institution:null},{id:"191392",title:"Dr.",name:"Marimuthu",middleName:null,surname:"Govindarajan",slug:"marimuthu-govindarajan",fullName:"Marimuthu Govindarajan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191392/images/5828_n.jpg",biography:"Dr. M. Govindarajan completed his BSc degree in Zoology at Government Arts College (Autonomous), Kumbakonam, and MSc, MPhil, and PhD degrees at Annamalai University, Annamalai Nagar, Tamil Nadu, India. He is serving as an assistant professor at the Department of Zoology, Annamalai University. His research interests include isolation, identification, and characterization of biologically active molecules from plants and microbes. He has identified more than 20 pure compounds with high mosquitocidal activity and also conducted high-quality research on photochemistry and nanosynthesis. He has published more than 150 studies in journals with impact factor and 2 books in Lambert Academic Publishing, Germany. He serves as an editorial board member in various national and international scientific journals.",institutionString:null,institution:null},{id:"274660",title:"Dr.",name:"Damodar",middleName:null,surname:"Paudel",slug:"damodar-paudel",fullName:"Damodar Paudel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274660/images/8176_n.jpg",biography:"I am DrDamodar Paudel,currently working as consultant Physician in Nepal police Hospital.",institutionString:null,institution:null},{id:"241562",title:"Dr.",name:"Melvin",middleName:null,surname:"Sanicas",slug:"melvin-sanicas",fullName:"Melvin Sanicas",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/241562/images/6699_n.jpg",biography:null,institutionString:null,institution:null},{id:"337446",title:"Dr.",name:"Maria",middleName:null,surname:"Zavala-Colon",slug:"maria-zavala-colon",fullName:"Maria Zavala-Colon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Puerto Rico, Medical Sciences Campus",country:{name:"United States of America"}}},{id:"338856",title:"Mrs.",name:"Nur Alvira",middleName:null,surname:"Pascawati",slug:"nur-alvira-pascawati",fullName:"Nur Alvira Pascawati",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Universitas Respati Yogyakarta",country:{name:"Indonesia"}}},{id:"441116",title:"Dr.",name:"Jovanka M.",middleName:null,surname:"Voyich",slug:"jovanka-m.-voyich",fullName:"Jovanka M. Voyich",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Montana State University",country:{name:"United States of America"}}},{id:"330412",title:"Dr.",name:"Muhammad",middleName:null,surname:"Farhab",slug:"muhammad-farhab",fullName:"Muhammad Farhab",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agriculture Faisalabad",country:{name:"Pakistan"}}},{id:"349495",title:"Dr.",name:"Muhammad",middleName:null,surname:"Ijaz",slug:"muhammad-ijaz",fullName:"Muhammad Ijaz",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}}]}},subseries:{item:{id:"95",type:"subseries",title:"Urban Planning and Environmental Management",keywords:"Circular economy, Contingency planning and response to disasters, Ecosystem services, Integrated urban water management, Nature-based solutions, Sustainable urban development, Urban green spaces",scope:"