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Barely three months into the new year and we are happy to announce a monumental milestone reached - 150 million downloads.
\n\nThis achievement solidifies IntechOpen’s place as a pioneer in Open Access publishing and the home to some of the most relevant scientific research available through Open Access.
\n\nWe are so proud to have worked with so many bright minds throughout the years who have helped us spread knowledge through the power of Open Access and we look forward to continuing to support some of the greatest thinkers of our day.
\n\nThank you for making IntechOpen your place of learning, sharing, and discovery, and here’s to 150 million more!
\n\n\n\n\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"10543",leadTitle:null,fullTitle:"Psychology and Pathophysiological Outcomes of Eating",title:"Psychology and Pathophysiological Outcomes of Eating",subtitle:null,reviewType:"peer-reviewed",abstract:"The psychology of eating is regulated by neural mechanisms. When not well controlled, eating may result in disorders and health hazards such as obesity, type 2 diabetes mellitus, and vascular diseases. Lifestyles and cultures influence eating habits, thus there are differences in the prevalence of health problems depending upon living environments. This book examines the psychology and the pathophysiological outcomes of eating. Chapters address such topics as the influence of lifestyle, circadian rhythm, sleep, and fragrant odors on appetite and weight regulation; the impact of glucose, sucrose, lactate, and ketone bodies on the brain; the consequences of glycation stress on the skeletal muscle; and much more.",isbn:"978-1-83968-777-8",printIsbn:"978-1-83968-776-1",pdfIsbn:"978-1-83968-778-5",doi:"10.5772/intechopen.92917",price:119,priceEur:129,priceUsd:155,slug:"psychology-and-pathophysiological-outcomes-of-eating",numberOfPages:272,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"2464b5fb6a39df380e935096743410a0",bookSignature:"Akikazu Takada and Hubertus Himmerich",publishedDate:"December 1st 2021",coverURL:"https://cdn.intechopen.com/books/images_new/10543.jpg",numberOfDownloads:2983,numberOfWosCitations:0,numberOfCrossrefCitations:2,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:9,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:11,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"September 11th 2020",dateEndSecondStepPublish:"October 9th 2020",dateEndThirdStepPublish:"March 29th 2021",dateEndFourthStepPublish:"May 14th 2021",dateEndFifthStepPublish:"June 15th 2021",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"7",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Hamamatsu University School of Medicine",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"231568",title:"Dr.",name:"Hubertus",middleName:null,surname:"Himmerich",slug:"hubertus-himmerich",fullName:"Hubertus Himmerich",profilePictureURL:"https://mts.intechopen.com/storage/users/231568/images/system/231568.png",biography:"Dr. Hubertus Himmerich is a clinical senior lecturer for eating disorders at King’s College London and a consultant psychiatrist on an inpatient ward for patients with eating disorders at Bethlem Royal Hospital, London, UK. Following medical school, Dr. Himmerich received his scientific and clinical training at the Max Planck Institute of Psychiatry, Germany, and the Universities of Mainz and Marburg, Germany. Afterwards, he worked as a consultant psychiatrist at the RWTH Aachen University Hospital and Professor of Neurobiology of Affective Disorders at the University of Leipzig, Germany. He has led and performed national and international scientific projects with researchers from Europe, Australia, and North America, and he has published more than 160 articles in peer-reviewed scientific journals, books, and book chapters.",institutionString:"King’s College London",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"4",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"King's College London",institutionURL:null,country:{name:"United Kingdom"}}},coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1061",title:"Psychiatry",slug:"mental-and-behavioural-disorders-and-diseases-of-the-nervous-system-psychiatry"}],chapters:[{id:"74852",title:"Attenuation of Food Intake by Fragrant Odors: Comparison between Osmanthus fragrans and Grapefruit Odors",doi:"10.5772/intechopen.95757",slug:"attenuation-of-food-intake-by-fragrant-odors-comparison-between-em-osmanthus-fragrans-em-and-grapefr",totalDownloads:243,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Odors affect various physiological and mental activities. Previous studies in rats have shown that the odors of grapefruit and Osmanthus fragrans (OSM, fragrant tea olive) attenuate food intake, leading to a reduction in body weight gain, but it is not yet clear whether the causative mechanisms underlying these effects are the same for both odors. The first part of the present study revealed that grapefruit odor had no effect on the expression of feeding-related neuropeptides, in contrast to the previous finding that OSM odor suppresses orexigenic and activates anorexigenic neuropeptides in the hypothalamus of the rat. The second part revealed that OSM odor activated the parasympathetic nerve, in contrast to the previous finding demonstrating that grapefruit odor activates sympathetic nerve activity. The third part was performed to confirm the previous findings about the effects of OSM odor on appetitive reactions in humans. In human subjects, we found that continuous exposure to OSM odor attenuated appetite and consumption of snacks (cookies) and improved mood, when evaluated using the POMS (Profile of Mood States) data from university students. In conclusion, OSM odor attenuated appetite and decreased food intake in humans, and the underlying causative mechanisms differed from those mediating the effects of grapefruit odor, specifically in terms of the expression of hypothalamic feeding-related neuropeptides and autonomic nerve activity.",signatures:"Takashi Yamamoto, Kayoko Ueji, Tadashi Inui and Haruno Mizuta",downloadPdfUrl:"/chapter/pdf-download/74852",previewPdfUrl:"/chapter/pdf-preview/74852",authors:[{id:"332858",title:"Prof.",name:"Takashi",surname:"Yamamoto",slug:"takashi-yamamoto",fullName:"Takashi Yamamoto"},{id:"344751",title:"Dr.",name:"Kayoko",surname:"Ueji",slug:"kayoko-ueji",fullName:"Kayoko Ueji"},{id:"344752",title:"Dr.",name:"Tadashi",surname:"Inui",slug:"tadashi-inui",fullName:"Tadashi Inui"},{id:"344753",title:"Ms.",name:"Haruno",surname:"Mizuta",slug:"haruno-mizuta",fullName:"Haruno Mizuta"}],corrections:null},{id:"75814",title:"Lactate and Ketone Bodies Act as Energy Substrates as Well as Signal Molecules in the Brain",doi:"10.5772/intechopen.97035",slug:"lactate-and-ketone-bodies-act-as-energy-substrates-as-well-as-signal-molecules-in-the-brain",totalDownloads:380,totalCrossrefCites:2,totalDimensionsCites:6,hasAltmetrics:0,abstract:"Astroglia or astrocytes, the most abundant cells in the brain, are interposed between neuronal synapses and the microvasculature in the brain’s gray matter. This unique anatomical location allows astroglia to play pivotal roles in brain metabolism as well as in the regulation of cerebral blood flow. In particular, astroglial cellular metabolic compartmentation exerts supportive roles in dedicating neurons to the generation of action potentials and protects neurons against the oxidative stress associated with their high energy consumption. Key products of astroglia include lactate and ketone bodies (beta-hydroxybutyrate and acetoacetate), which can also be produced avidly by muscle and liver, respectively. Therefore, brain cells, skeletal muscles, and hepatocytes constitute a metabolic compartmentation in the whole body. In this chapter, I will focus on brain cells, especially astroglia, since the impairment of normal astroglial function can lead to numerous neurological disorders including stroke, neurodegenerative diseases, and neuro-immunological diseases. I will also discuss the metabolic responses of brain cells in terms of food consumption and exercise. A better understanding of the astroglial metabolic response is expected to lead to the development of novel therapeutic strategies for diverse neurological diseases.",signatures:"Shinichi Takahashi",downloadPdfUrl:"/chapter/pdf-download/75814",previewPdfUrl:"/chapter/pdf-preview/75814",authors:[{id:"334122",title:"Dr.",name:"Shinichi",surname:"Takahashi",slug:"shinichi-takahashi",fullName:"Shinichi Takahashi"}],corrections:null},{id:"77738",title:"Roles of Glucose and Sucrose Intakes on the Brain Functions Measured by the Working Ability and Morris Maze",doi:"10.5772/intechopen.99203",slug:"roles-of-glucose-and-sucrose-intakes-on-the-brain-functions-measured-by-the-working-ability-and-morr",totalDownloads:168,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Sugars such as glucose or sucrose are considered hazardous foods because their intakes lead to obesity, further causing diabetes mellitus (DM), or cardiovascular diseases. However, glucose is needed for many brain functions such as memory and emotion among others. Glucose induces the secretion of insulin, which is needed for transportation of tryptophan from the blood to the brain. Serotonin, which is converted from tryptophan, is important for mood stability, control of emotion, and feeding is inhibited by serotonin in the hypothalamus. We discuss transportation of glucose from the blood to the glia cells. After glycolysis of glucose in the glia lactic acid is transported to cells such as glutaminergic neurons. After the release from neurons glutamic acid is taken up into glia cells and further to neurons again. Sucrose is degraded into glucose and fructose in the intestine thus intake of sucrose increases plasma levels of glucose. We show that intake of sucrose enhanced memory measured by Morris maze in rats and improved the working ability in humans. Roles of glucose and sucrose intakes are discussed together with the function of serotonin in feeding.",signatures:"Akikazu Takada, Fumiko Shimizu, Yukie Ishii, M. Ogawa and Tetsuya Takao",downloadPdfUrl:"/chapter/pdf-download/77738",previewPdfUrl:"/chapter/pdf-preview/77738",authors:[{id:"248459",title:"Dr.",name:"Akikazu",surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada"}],corrections:null},{id:"78899",title:"Circadian Clock, Sleep, and Diet",doi:"10.5772/intechopen.100421",slug:"circadian-clock-sleep-and-diet",totalDownloads:136,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Circadian rhythm is a fundamental process of sustaining metabolic homeostasis by predicting changes in the environment. This is driven by biological clocks, which operate within a 24-h period to orchestrate daily variation of metabolism and sleep. The central clock in the hypothalamus is the master keeper of the circadian rhythm and is primarily reset by light, while the feeding-fasting rhythm, that is, nutritional stimulus, entrains peripheral clocks in peripheral organs such as the intestine and liver. Nutritional stimuli are important modulators of peripheral circadian rhythms and may affect the central clock and sleep homeostasis through metabolic alterations. In this chapter, I will summarize the significance of circadian rhythm and sleep in metabolic regulation as well as discuss the impact that diet has on circadian rhythm and sleep.",signatures:"Junichiro Irie",downloadPdfUrl:"/chapter/pdf-download/78899",previewPdfUrl:"/chapter/pdf-preview/78899",authors:[{id:"335497",title:"Assistant Prof.",name:"Junichiro",surname:"Irie",slug:"junichiro-irie",fullName:"Junichiro Irie"}],corrections:null},{id:"78567",title:"ER Stress Response Failure and Steatohepatitis Comorbid with Diabetes",doi:"10.5772/intechopen.100054",slug:"er-stress-response-failure-and-steatohepatitis-comorbid-with-diabetes",totalDownloads:176,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Dynamic metabolic changes occur in the liver during the transition between fasting and eating, which is mainly mediated by insulin, a hormone to promote anabolism and suppress catabolism. In obesity and diabetes, insulin resistance is induced via various mechanisms, and among them is endoplasmic reticulum (ER) stress. We recently reported that eating induces transient ER stress and consequent ER stress response in the liver. During eating, expression of Sdf2l1, an ER-resident molecule involved in ER stress-associated degradation, is induced as a part of ER stress response. XBP-1s regulates expression of Sdf2l1 at the transcription level, and Sdf2l1 terminates eating-induced ER stress in the liver, consequently regulating glucose and lipid metabolism. In obesity and diabetes, however, ER stress response is impaired, partly because insulin-mediated translocation of XBP-1s to the nucleus is suppressed, which results in further excessive ER stress. Induction of Sdf2l1 by XBP-1s is highly down-regulated, but restoration of Sdf2l1 ameliorates glucose intolerance and fatty liver. In diabetic patients, hepatic insulin resistance induces enhanced ER stress and ER stress response failure in the liver, which in turn promote hepatic fibrosis and contribute to the development of steatohepatitis comorbid with diabetes.",signatures:"Takayoshi Sasako and Kohjiro Ueki",downloadPdfUrl:"/chapter/pdf-download/78567",previewPdfUrl:"/chapter/pdf-preview/78567",authors:[{id:"344302",title:"Assistant Prof.",name:"Takayoshi",surname:"Sasako",slug:"takayoshi-sasako",fullName:"Takayoshi Sasako"},{id:"429058",title:"Prof.",name:"Kohjiro",surname:"Ueki",slug:"kohjiro-ueki",fullName:"Kohjiro Ueki"}],corrections:null},{id:"76602",title:"The Effect of Glycation Stress on Skeletal Muscle",doi:"10.5772/intechopen.97769",slug:"the-effect-of-glycation-stress-on-skeletal-muscle",totalDownloads:265,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Glycation stress (glycative stress) is a general concept of biological stress caused by a series of non-enzymatic glycation reactions, including advanced glycation end products (AGEs) formation, AGEs accumulation, glycation-associated dysfunction of proteins and cellular signaling, inflammation, oxidation, and/or tissue damage. There has been increasing evidence supporting a profound effect of AGEs on human diseases such as type 2 diabetes, cardiovascular disease, cancer, Alzheimer’s disease, osteoporosis, and dementia, as well as aging process itself. In addition, dietary AGEs intake has also been suggested to contribute to tissue dysfunction and development of the diseases. Skeletal muscle is the largest organ in the human body and important responsibility for maintaining our health as not only locomotor system but also metabolic and endocrine systems. Especially in past decades, numerous studies have suggested the contribution of glycation stress to skeletal muscle dysfunctions (e.g. muscle atrophy, reducing contractile property, and insulin resistance). In this chapter, we provide current evidence on the potential role of glycation stress in the impairment of skeletal muscle functions.",signatures:"Tatsuro Egawa, Kohei Kido, Takumi Yokokawa, Mami Fujibayashi, Katsumasa Goto and Tatsuya Hayashi",downloadPdfUrl:"/chapter/pdf-download/76602",previewPdfUrl:"/chapter/pdf-preview/76602",authors:[{id:"193127",title:"Prof.",name:"Katsumasa",surname:"Goto",slug:"katsumasa-goto",fullName:"Katsumasa Goto"},{id:"193128",title:"Prof.",name:"Tatsuya",surname:"Hayashi",slug:"tatsuya-hayashi",fullName:"Tatsuya Hayashi"},{id:"342798",title:"Dr.",name:"Tatsuro",surname:"Egawa",slug:"tatsuro-egawa",fullName:"Tatsuro Egawa"},{id:"355790",title:"Dr.",name:"Kohei",surname:"Kido",slug:"kohei-kido",fullName:"Kohei Kido"},{id:"355791",title:"Dr.",name:"Takumi",surname:"Yokokawa",slug:"takumi-yokokawa",fullName:"Takumi Yokokawa"},{id:"355792",title:"Prof.",name:"Mami",surname:"Fujibayashi",slug:"mami-fujibayashi",fullName:"Mami Fujibayashi"}],corrections:null},{id:"78900",title:"Metabolic Responses to Energy-Depleted Conditions",doi:"10.5772/intechopen.100391",slug:"metabolic-responses-to-energy-depleted-conditions",totalDownloads:201,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:1,abstract:"Dietary intervention is one of the most important approaches for the treatment of metabolic diseases such as diabetes mellitus. Fasting and caloric restriction have profound effects on systemic metabolism. The energy source-producing organs, such as the liver, and peripheral tissues rewire their metabolism to meet the energy demands of the whole body. Glycogenolysis, fatty acid oxidation, and ketone body production are characteristic metabolic changes that occur during fasting and caloric restriction. These metabolic changes are regulated by various signaling cascades including PPARα and FGF21. Moderate fasting and caloric restriction have also been implicated in extending the lifespan in a variety of organisms from nematodes to vertebrates. Intensive research has unveiled several regulatory mechanisms of longevity including metabolic regulators such as mTOR and sirtuins. The epigenome has been attracting attention as a mechanism underlying metabolic diseases and longevity. The epigenome is the concept that involves covalent modifications of DNA, histones, and RNA, which are mediated by the action of epigenetic enzymes. The activity of these enzymes is regulated by energy states, i.e. metabolites including ketone bodies and intermediates of various metabolic pathways. Thus, energy states are recorded in cells as an epigenetic memory, which may cause future onset of metabolic diseases and affect lifespan.",signatures:"Tomohiro Suzuki, Tetsuro Komatsu, Hiroshi Shibata and Takeshi Inagaki",downloadPdfUrl:"/chapter/pdf-download/78900",previewPdfUrl:"/chapter/pdf-preview/78900",authors:[{id:"344282",title:"Prof.",name:"Takeshi",surname:"Inagaki",slug:"takeshi-inagaki",fullName:"Takeshi Inagaki"},{id:"435038",title:"Dr.",name:"Tomohiro",surname:"Suzuki",slug:"tomohiro-suzuki",fullName:"Tomohiro Suzuki"},{id:"435300",title:"Dr.",name:"Tetsuro",surname:"Komatsu",slug:"tetsuro-komatsu",fullName:"Tetsuro Komatsu"},{id:"435301",title:"Dr.",name:"Hiroshi",surname:"Shibata",slug:"hiroshi-shibata",fullName:"Hiroshi Shibata"}],corrections:null},{id:"78805",title:"Role of Gut Microbiota in Bile-Acid Metabolism",doi:"10.5772/intechopen.100440",slug:"role-of-gut-microbiota-in-bile-acid-metabolism",totalDownloads:158,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The role of the gut microbiota in modifying the pathophysiology of various diseases, including neurodegenerative diseases, is increasingly becoming clear. Bile acids have been shown to be endogenous factors that affect gut microbiota, and bile-acid metabolites directly or indirectly affect host physiology and pathophysiology. The development of metagenomic analysis for gut microbiota and systematic bile-acid measurement using LC–MS/MS has triggered a breakthrough for research in this field. Clinically, an inhibitor of the ileal bile-acid transporter (Elobixibat) was used as a therapeutic agent for chronic constipation, which also paved the way for progress in bile-acid signal research. Additionally, this review emphasizes the importance of gut microbiota-bile acid-receptor signals when considering nutritional approaches to promote healthy longevity.",signatures:"Yuji Naito, Tomohisa Takagi and Ryo Inoue",downloadPdfUrl:"/chapter/pdf-download/78805",previewPdfUrl:"/chapter/pdf-preview/78805",authors:[{id:"157629",title:"Dr.",name:"Yuji",surname:"Naito",slug:"yuji-naito",fullName:"Yuji Naito"}],corrections:null},{id:"77355",title:"Relations between Dietary Habits, Lifestyle and Leading Obesity",doi:"10.5772/intechopen.98307",slug:"relations-between-dietary-habits-lifestyle-and-leading-obesity",totalDownloads:152,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Obesity, hypertension, depression currently in the rise are some of the many problems faced by a common person due to poor dietary and sleeping habits along with some genetic disorders. An extensive study has been done over two years with 205 subjects regarding their eating & sleeping habits and their mental & physical state on a day-to-day basis. The subjects include both males and females ranging from 15 years of age to 70 above. Altogether 12.68% of people suffer from obesity while just 51.21% of them have an appropriate weight. Women below the age of 25 have shown an overpowering presence of PCOS affecting their health and 38.53% of the population showcasing suffering from hypertension and 14.14% suffering from depression. Sleep has yet proven to be a defining factor in wellbeing. 17.07% of the population exhibit signs of sleep deprivation while just 63.9% of the population sleep over 7 hours daily. Like many other countries, in India, the shift from traditional healthy food to fast food & processed food is taking place, resulting in various health problems like obesity, heart problems, arthritis, weakness, diabetes, high blood pressure, difficulty in breathing, stroke & so on. The aim of this meta-analysis was to quantify the effects of nutrition, mental health and exercise on the various aspects of a person’s well-being.",signatures:"Shradha Mistri",downloadPdfUrl:"/chapter/pdf-download/77355",previewPdfUrl:"/chapter/pdf-preview/77355",authors:[{id:"339672",title:"M.Sc.",name:"Shradha",surname:"Mistri",slug:"shradha-mistri",fullName:"Shradha Mistri"}],corrections:null},{id:"77563",title:"Hypertension as Three Systematic Dysregulations of Na+ Homeostasis in Terrestrial Mammal, and Salt in Gut Might Cause Brain Inflammation",doi:"10.5772/intechopen.98904",slug:"hypertension-as-three-systematic-dysregulations-of-na-sup-sup-homeostasis-in-terrestrial-mammal-and-",totalDownloads:170,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Although Na+ homeostasis in vivo is essential for mammals, it is known that excessive salt (NaCl) intake has played a major role in the development of hypertension. In vivo, there is a hormonal system, the renin-angiotensin-aldosterone system (RAAS), that specializes in regulating Na+ retention, especially the amount of Na+ in plasma. Na+ homeostasis in vivo has been achieved mainly by the RAAS, through regulation of vascular tonus (blood pressure) and Na+ handling in the kidney (Na+ diuresis). Recent studies have revealed a third mechanism of Na+ homeostasis in vivo: regulation of interstitial Na+ levels in tissues, such as subcutaneous tissues, by tissue macrophage immunity. In the pathogenesis of salt-sensitive hypertension, Recent research have been revealed that three molecular axes (Ang II - Rho/NOX-eNOS system, Aldosterone-rac1 -ENaC system, and tissue Na+ − TonEBP in macrophage -VEGF-c) are significantly involved in maintaining Na+ homeostasis in salt induced hypertension. Furthermore, the mechanism by which salt causes hypertension via the immune system (intestinal, local mucosal, and tissue immunity) has also been reported. In this article, we would like to propose that three molecular dysfunctions are involved in the development of salt-sensitive hypertension through three immunological mechanisms in the maintenance of Na+ homeostasis. Next, I would like to explain the importance of gut-RAAS and abnormality of intestinal microflora (dysbiosis) in salt-sensitive hypertension. It has been known that the metabolites (e.g., short-chain fatty acid neural amino) produced by microflora are deeply involved in central (CNS) and sympathetic nervous system (SNS) activity. In addition, we would like to explain of the importance of brain-RAAS and cerebral inflammation in salt-sensitive hypertension. Moreover, recent research have revealed that the detection-mechanism in the brain for Na+ concentration([Na+]) in vivo and in the tongue for [Na+] in diet. These finding suggests that excessive salt intake may cause brain dysfunction, most delicate organ, before the onset of salt sensitive hypertension, and may also destroy brain structure after the onset of salt sensitive hypertension. Thus, we would like to insist that excessive salt intake might not only induce hypertension, but also be toxic especially for brain. Finally, we would like to explain that The DASH diet (Dietary Approaches to Stop Hypertension) is one of the universal diets for adult human, not only by reducing salt, but also by reducing metabolic stress and improving of dysbiosis.",signatures:"Mizuo Mifune and Yoshihiko Kanno",downloadPdfUrl:"/chapter/pdf-download/77563",previewPdfUrl:"/chapter/pdf-preview/77563",authors:[{id:"332618",title:"Prof.",name:"Yoshihiko",surname:"Kanno",slug:"yoshihiko-kanno",fullName:"Yoshihiko Kanno"},{id:"419975",title:"Dr.",name:"Mizuo",surname:"Mifune",slug:"mizuo-mifune",fullName:"Mizuo Mifune"}],corrections:null},{id:"76800",title:"Effect of Lifestyle Modification on Glycemic Control of Type 2 Diabetic Patients at Suez Canal University Hospitals",doi:"10.5772/intechopen.97738",slug:"effect-of-lifestyle-modification-on-glycemic-control-of-type-2-diabetic-patients-at-suez-canal-unive",totalDownloads:254,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Type 2 Diabetes mellitus, as one of the major universal public health disorders wide spread, requires patients’ lifestyle modulation which would be conducive in dominating blood glucose. The aim of the study was to evaluate the effect of lifestyle modification on glycemic control of type 2 diabetic patients at Suez Canal University Hospitals at Ismailia city. A quasi-experimental design made up of a control group and a study group with pre- and post-test administration was applied. This study was carried out at the Family Medicine Outpatient Clinic and the Diabetic Outpatient Clinic of Suez Canal University Hospitals at Ismailia city in Egypt. 92 type 2 diabetic patients were included in this study. The Diabetes Knowledge Questionnaire; Health promoting lifestyle profile II Scale; and Physical assessment sheet were used for data collection in the two groups. After implementing of the program, those patients who received lifestyle modification intervention achieved better total score of knowledge & knowledge related practice about DM, health promoting lifestyle domains values and glycated hemoglobin, compared with the control group. Factors related to lower glycated hemoglobin in the present study were lower fasting blood sugar level and increasing physical activity. Overall, lifestyle modification program has a positive influence on blood glucose control of patients with type 2 diabetes mellitus. Therefore, it is recommended to that lifestyle modification interventions should be integral part of the curative management of type 2 diabetic patients, and further study in other places to investigate the effect of lifestyle modification on glycemic control of those patients.",signatures:"Fatma Ibrahim Abdel-Latif Megahed, Salwa Abbas Ali Hassan, Hassan Ali Abdelwahid and Hanaa Kassem Farg",downloadPdfUrl:"/chapter/pdf-download/76800",previewPdfUrl:"/chapter/pdf-preview/76800",authors:[{id:"338636",title:"Dr.",name:"Fatma Ibrahim Abdel-Latif",surname:"Megahed",slug:"fatma-ibrahim-abdel-latif-megahed",fullName:"Fatma Ibrahim Abdel-Latif Megahed"},{id:"415846",title:"Dr.",name:"Salwa Abbas",surname:"Ali Hassan",slug:"salwa-abbas-ali-hassan",fullName:"Salwa Abbas Ali Hassan"},{id:"415847",title:"Dr.",name:"Hassan Ali",surname:"Abdelwahid",slug:"hassan-ali-abdelwahid",fullName:"Hassan Ali Abdelwahid"},{id:"415848",title:"Dr.",name:"Hanaa Kassem",surname:"Farg",slug:"hanaa-kassem-farg",fullName:"Hanaa Kassem Farg"}],corrections:null},{id:"77713",title:"Psychotherapeutic Interventions for Type 2 Diabetes Mellitus",doi:"10.5772/intechopen.97653",slug:"psychotherapeutic-interventions-for-type-2-diabetes-mellitus",totalDownloads:128,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This chapter explores the efficacy of psychotherapeutic interventions for patients with type 2 diabetes mellitus (T2DM). This condition can lead to serious adverse health outcomes (e.g., cardiovascular disease, blindness, loss of limbs, etc.). Medical interventions alone are often not sufficient to manage the disease. Psychotherapy can promote behavioral change that improves medication adherence, dietary choices, exercise, stress, and other variables that affect blood sugar levels. The current chapter summarizes the trends in recent research for psychotherapeutic interventions for the management of T2DM. The results from 16 randomized controlled trials on cognitive-behavioral therapy, motivational interviewing, counseling, and mindfulness-based therapies are discussed. These interventions varied in length (3 to 18 months) and were conducted in many geographic regions (e.g., Australia, Netherlands, Saudi Arabia, Thailand, and more). Changes in biological health outcomes (i.e., HbA1c levels) were the primary focus of this chapter, but diabetes-related behavioral changes (e.g., diet and exercise) and psychological variables (e.g., stress, depression, and well-being) are also discussed. This chapter highlights that recent research has provided the most support for mindfulness-based therapies for improving blood sugar levels in patients with T2DM.",signatures:"Keisha C. Gobin, Jennifer S. Mills and Joel D. Katz",downloadPdfUrl:"/chapter/pdf-download/77713",previewPdfUrl:"/chapter/pdf-preview/77713",authors:[{id:"202110",title:"Dr.",name:"Jennifer S.",surname:"Mills",slug:"jennifer-s.-mills",fullName:"Jennifer S. Mills"},{id:"343000",title:"Ph.D. Student",name:"Keisha C.",surname:"Gobin",slug:"keisha-c.-gobin",fullName:"Keisha C. Gobin"},{id:"354578",title:"Dr.",name:"Joel D.",surname:"Katz",slug:"joel-d.-katz",fullName:"Joel D. Katz"}],corrections:null},{id:"77412",title:"Diet and Obesity",doi:"10.5772/intechopen.98326",slug:"diet-and-obesity",totalDownloads:166,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Obesity is a complex disease that involves an excessive amount of body fat. It is a medical problem that increases the risk of other diseases, such as heart disease, diabetes, high blood pressure and certain cancers. Although there are genetic, behavioral, metabolic and hormonal influences on body weight, obesity occurs when you take in more calories than you burn through exercise and daily activities that is when energy intake exceeds energy expenditure. Diet plays an important role in the pathogenesis of obesity; fatty foods are energy dense and gives 9calories per gram compared to carbohydrate and protein that gives 4calories per gram. Also, if physical activity is inadequate, excess consumption of fat can results into weight gain. It does not take as much energy (about 3%), to convert and store dietary fat as it does to convert and store glucose. Fats are easily stored by the body. The aim of this chapter is to provide an understanding of physiological causes and effects of obesity as this will help to promote positive food choices. It is probable that an understanding of dietary patterns and how it relates to obesity will go a long way in the treatment of this complex problem.",signatures:"Olariike Oyindasola Kayode",downloadPdfUrl:"/chapter/pdf-download/77412",previewPdfUrl:"/chapter/pdf-preview/77412",authors:[{id:"334944",title:"Ph.D. Student",name:"Olariike",surname:"Oyindasola Kayode",slug:"olariike-oyindasola-kayode",fullName:"Olariike Oyindasola Kayode"}],corrections:null},{id:"74591",title:"The Outcome of Eating Disorders: Relapse, Childbirth, Postnatal Depression, Family Support",doi:"10.5772/intechopen.95452",slug:"the-outcome-of-eating-disorders-relapse-childbirth-postnatal-depression-family-support",totalDownloads:386,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"This study was aimed to identify eating disorder (ED) relapse, childbirth, postnatal depression,and the family support. Of the ED patients during treatment from 1994 to 2004,55 were pregnant and had ED recovery. Of them, 25 (21 Bulimia Nervosa (BN)and 4 Anorexia Nervosa (AN)) agreed to take part in this study. We interviewed them every 2 wk. both during the pregnancy and after childbirth. We also interviewed family members each month. The Eating Attitudes Test-26 (EAT-26) and Edinburgh Postnatal Depression Scale (EPDS) were helpful for diagnosing the EDs and postnatal depression. As the statistical analysis, We conducted t-test.67%relapsed ED while pregnant and 50%relapsed postnatal. In the non-relapse group, all the subjects had vaginal delivery and their infants were male. 50% of the subjects had postnatal depression. Non-Postnatal depression group had average body- weight infants. With regard to family support, there was no relationship between ED relapse and postnatal depression. We found that the rate of ED relapse and that of suffering from postnatal depression were remarkable in this group, suggesting the necessity for long-term follow-up for the EDs.",signatures:"Mariko Makino, Mitsuo Yasushi and Masahiro Hashizume",downloadPdfUrl:"/chapter/pdf-download/74591",previewPdfUrl:"/chapter/pdf-preview/74591",authors:[{id:"332255",title:"Ph.D.",name:"Mariko",surname:"Makino",slug:"mariko-makino",fullName:"Mariko Makino"},{id:"336867",title:"Dr.",name:"Masahiro",surname:"Hashizume",slug:"masahiro-hashizume",fullName:"Masahiro Hashizume"},{id:"345671",title:"Dr.",name:"Mitsuo",surname:"Yasushi",slug:"mitsuo-yasushi",fullName:"Mitsuo Yasushi"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"7841",title:"New Insights Into Metabolic Syndrome",subtitle:null,isOpenForSubmission:!1,hash:"ef5accfac9772b9e2c9eff884f085510",slug:"new-insights-into-metabolic-syndrome",bookSignature:"Akikazu Takada",coverURL:"https://cdn.intechopen.com/books/images_new/7841.jpg",editedByType:"Edited by",editors:[{id:"248459",title:"Dr.",name:"Akikazu",surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"510",title:"Anxiety Disorders",subtitle:null,isOpenForSubmission:!1,hash:"183445801a9be3bfbce31fe9752ad3db",slug:"anxiety-disorders",bookSignature:"Vladimir Kalinin",coverURL:"https://cdn.intechopen.com/books/images_new/510.jpg",editedByType:"Edited by",editors:[{id:"31572",title:null,name:"Vladimir V.",surname:"Kalinin",slug:"vladimir-v.-kalinin",fullName:"Vladimir V. 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Public health protection is of paramount importance that demands the rapid and accurate detection and quantitation of microorganisms in potable water and in various raw and processed foods to prevent undesirable outbreaks of microbial contamination. Water quality has been assessed for potable and recreational activities using culture-dependent quantification and sensing of fecal indicator bacteria (FIB), such as total coliforms,
Waterborne diseases have been one of the major causes due to the consumption of contaminated water affecting seriously the public health of a humongous number of people in quick succession. In the 2014–2016 survey, the detection rate of pathogenic bacteria was 79.3%, followed by pathogenic
Between 2013 and 2016, a monocentric hospital-based investigation showed that
Coliforms, particularly
Traditional microbiological detection techniques consume time as
It is necessary to develop new approaches for detecting
PCR being a mighty and handy tool with molecular biologists showed enormous potential in various forms including multiplex PCR and quantitative real-time PCR. The advantage of PCR is that despite its inability to distinguish between live and dead cells, nonculturable cells may be detected rapidly. In the recent two decades, various PCR-based strategies have been introduced to improve the detection of indicator organisms [23, 24]. Genetic markers such as 23S rRNA and lacZ are often used to establish PCR tests for detecting
The
Li et al. [43] established a multiplex real-time PCR test that targets the
Being a rapid, sensitive, and specific method enabling the detection of multiple pathogens simultaneously this method finds applications in different types of foods and poultry industries. Nguyen et al. [45] developed a multiplex PCR for the rapid and simultaneous detection of three epidemic food-borne pathogens:
In developing countries, the identification of enteric pathogens in food and other edible items are time-consuming process and often results in wrong and delayed diagnosis. Enteropathogenic
Toma et al. [49] used a single-tube mPCR for the identification of enteropathogenic
Chen et al. [50] developed a multiplex rtPCR assay for the identification of diarrheagenic
Detection of harmful bacteria with higher specificity, sensitivity, and reliability is the focus of nucleic acid-based approaches. The desired nucleic acid sequence is hybridized to a synthetic oligonucleotide for specific detection of the pathogen [51]. Nucleic acid-based approaches are routinely used to detect bacterial infections and their toxin-producing genes [51]. Nucleic acid-based methods are rapid and easy to use, and they do not require the pathogens to be cultured (Figure 1).
Schematic depicting the steps in culture-independent detection of
Even a decade ago, the identification and measurement of specific target genes with absolute accuracy and as little as a few copies in a matter of hours was a dream. In the area of water quality assessment, however, qPCR technology has proven to be a powerful technique [53]. Unlike the classical PCR, which needs agarose-gel electrophoresis to identify the end-point PCR products, the qPCR enables assessing PCR product amplification by measuring fluorescence signals released by specialized dual-labeled probes or the intercalating dyes. The fluorescence intensity generated during the qPCR is directly related to the quantity of PCR products produced [12, 54, 55]. The most often used fluorescent systems for qPCR include SYBR green, TaqMan probes, and molecular beacons [56]. The qPCR techniques, which have higher specificity, sensitivity, and reliability than classic culture methods and mPCR [57], allow for the time-efficient detection of harmful bacteria with higher specificity, sensitivity, and reliability [12, 56, 58]. Although the qPCR has been used to detect and quantify
Utilizing TaqMan probes labeled with different fluorophores, microfluidic qPCR was shown to identify pathogens such as
In another study, Liu et al. [66] reported designing of the novel oligonucleotide primer set and TaqMan probes targeting the specific virulence genes of twelve common food pathogens such as
In order to circumvent the use of thermocyclers that entail the time-consuming thermal cycling, an innovative method such as isothermal DNA amplification has been introduced which finds its application in the advanced Research & Development (R & D) unit of the food industry. The LAMP reaction that involves isothermal amplification chemistry has a good range of possible applications, including point-of-care testing with the potential of getting developed into portable diagnostic systems, and quick testing of food products, clinical and environmental samples.
The isothermal characteristics of LAMP enable the simplification of the detection process without involving any costly and complex instrumentation wherein a simple heating block or a precise digital water bath would work. Though conventional PCR and LAMP techniques were reported to be vulnerable to several inhibitors while testing various biological (for example urinary and plant materials) matrices [64], yet LAMP is much less sensitive to amplification inhibitors [64], potentially permitting its application bypassing the general requirement for cultural enrichment or DNA purification.
Despite some disadvantages like its qualitative nature of detection, the LAMP offers several advantages over PCR. LAMP assay emphasizes the requirement of a heating block and obviates the need for a thermal cycler. Unlike PCR that requires DNA extraction from samples for amplification, LAMP assay does not require DNA extraction step. The difficulties in amplifying DNA in PCR from unprocessed urinary samples in the presence of a high concentration of urea were reported by Khan et al. [65]. Therefore the LAMP assay, by rendering the DNA extraction step redundant, has made the process more rapid and facile [67]. The implementation of LAMP does not require any denatured template as due to the use of Bst DNA polymerase from
Schematic representation of the principle steps in a LAMP assay and localization of the eight LAMP primers for specific amplification of target DNA. Adapted from Gallas-Lindemann et al. [
The very purpose of inner primers that consisted of two different sequences was to recognize a sense and antisense sequences of the target viral DNA, and the outer primers were designed to recognize an external sequence of the target viral DNA [69]. Additionally, in the LAMP assay, as an advantage, the identification of a positive reaction does not involve any special processing or electrophoresis. Only the visual observation of color change of the reaction mix in normal light is enabled when the appropriate DNA-binding dye is used. Thus, LAMP positive results could be better detected through visual observation of turbidity changes [70]. This visualization process can be improved by a UV transilluminator. Hill et al. [67] had demonstrated the use of propidium iodide for detecting the LAMP products.
In order to detect generic
It is to be noted that the LAMP assay reported by Hill et al. [67] was able to detect a large number of strains with very high sensitivity. Since biological samples such as cerebrospinal fluid and blood require very high sensitivity as compared to urine samples LAMP can be suitably modified for its clinical uses. LAMP has also been proposed to detect a lower copy number in partially treated infections (post-empirical antibiotic doses) [67].
A biosensor typically consists of a bioreceptor element with a transducer. The bioreceptor, interacts specifically with the analyte, whereas the transducer converts the biomolecular interaction into an electronic signal. Three basic parts of a biosensor are recognition material, transducer or detector system, and signal processor [74]. Monitoring the molecular interaction between the DNA-based bioreceptor and the analyte is an essential element of various DNA-based sensing strategies. The measurement methods of DNA–DNA interactions that take place on the various sensor surfaces are gaining much interest to improve sensor performance. The assays are applicable to the determination of low numbers of
Arora et al. [77] reported an electrochemical DNA biosensor for the detection of
Since its discovery in the 1980s, the system has demonstrated widespread applications in basic biotechnology research and disease treatment [80, 81]. A pressing need of the hour is the availability of a cost-efficient, rapid and selective molecular diagnostic platform to detect different pathogens and lethal diseases in the early stage of the infection. Quantitative PCR and metagenomic next-generation sequencing (mNGS) are the most commonly explored molecular platforms for the same; however, these methods have their disadvantages and limitations. Clustered Regularly Interspaced Short Palindromic Repeat/associated protein (CRISPR/Cas)-based diagnostic platform for the detection of nucleic acids has progressively demonstrated its potential as an ideal diagnostic approach for pathogens, cancer biomarker, and single-nucleotide polymorphisms (SNPs) detection. CRISPR systems have evolved in prokaryotes as a defensive mechanism against foreign viruses by cleaving their nucleic acids [82, 83, 84].
Additionally, the unique cleavage activity of Cas9 is often utilized for the development of ultra-low abundance DNA biosensors. A highly innovative and sensitive CRISPR/Cas9 system was developed by Huang et al. [84] that triggered isothermal exponential amplification reaction (CAS-EXPAR) strategy to detect DNA targets with attomolar (aM) sensitivity and single-base specificity [84]. CAS-EXPAR was primed by the target DNA fragment produced by cleavage of CRISPR/Cas9, and associated with the cyclical amplification reaction to produce numerous DNA replicates capable of getting detected by a real-time SYBR Green fluorescence signal [83].
Recently, Sun et al. [84] reported the detection of
CRISPR/Cas9 platform coupled with two-step isothermal amplification for detection of
Molecular diagnostic platforms have become promising alternatives to traditional methods for
The authors declare no conflict of interest.
IntechOpen aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. We uphold a flexible Copyright Policy, guaranteeing that there is no transfer of copyright to the publisher and Authors retain exclusive copyright to their Work.
',metaTitle:"Publication Agreement - Monograph",metaDescription:"IntechOpen aims to guarantee that original material is published while at the same time giving significant freedom to our authors. For that matter, we uphold a flexible copyright policy meaning that there is no transfer of copyright to the publisher and authors retain exclusive copyright to their work.",metaKeywords:null,canonicalURL:"/page/publication-agreement-monograph",contentRaw:'[{"type":"htmlEditorComponent","content":"When submitting a manuscript, the Author is required to accept the Terms and Conditions set out in our Publication Agreement – Monographs/Compacts as follows:
\\n\\nCORRESPONDING AUTHOR'S GRANT OF RIGHTS
\\n\\nSubject to the following Article, the Author grants to IntechOpen, during the full term of copyright, and any extensions or renewals of that term, the following:
\\n\\nThe foregoing licenses shall survive the expiry or termination of this Publication Agreement for any reason.
\\n\\nThe Author, on his or her own behalf and on behalf of any of the Co-Authors, reserves the following rights in the Work but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Work as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\\n\\nThe Author, and any Co-Author, confirms that they are, and will remain, a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\\n\\nSubject to the license granted above, copyright in the Work and all versions of it created during IntechOpen's editing process, including all published versions, is retained by the Author and any Co-Authors.
\\n\\nSubject to the license granted above, the Author and Co-Authors retain patent, trademark and other intellectual property rights to the Work.
\\n\\nAll rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the specific approval of the Author or Co-Authors.
\\n\\nThe Author, on his/her own behalf and on behalf of the Co-Authors, will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Work as a consequence of IntechOpen's changes to the Work arising from the translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits as determined by IntechOpen.
\\n\\nAUTHOR'S DUTIES
\\n\\nWhen distributing or re-publishing the Work, the Author agrees to credit the Monograph/Compacts as the source of first publication, as well as IntechOpen. The Author guarantees that Co-Authors will also credit the Monograph/Compacts as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Work.
\\n\\nThe Author agrees to:
\\n\\nThe Author will be held responsible for the payment of the agreed Open Access Publishing Fee before the completion of the project (Monograph/Compacts publication).
\\n\\nAll payments shall be due 30 days from the date of issue of the invoice. The Author or whoever is paying on behalf of the Author and Co-Authors will bear all banking and similar charges incurred.
\\n\\nThe Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Work worldwide for the full term of the above licenses, and shall provide to IntechOpen, at its request, the original copies of such consents for inspection or the photocopies of such consents.
\\n\\nThe Author shall obtain written informed consent for publication from those who might recognize themselves or be identified by others, for example from case reports or photographs.
\\n\\nThe Author shall respect confidentiality during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Author and Co-Authors are confidential and are intended only for the recipients. The contents of any communication may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\\n\\nAUTHOR'S WARRANTY
\\n\\nThe Author and Co-Authors confirm and warrant that the Work does not and will not breach any applicable law or the rights of any third party and, specifically, that the Work contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy.
\\n\\nThe Author and Co-Authors confirm that: (i) the Work is their original work and is not copied wholly or substantially from any other work or material or any other source; (ii) the Work has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) Authors and any applicable Co-Authors are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) Authors and any applicable Co-Authors have not assigned, and will not during the term of this Publication Agreement purport to assign, any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\\n\\nThe Author and Co-Authors also confirm and warrant that: (i) he/she has the power to enter into this Publication Agreement on his or her own behalf and on behalf of each Co-Author; and (ii) has the necessary rights and/or title in and to the Work to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licences in this Publication Agreement. If the Work was prepared jointly by the Author and Co-Authors, the Author confirms that: (i) all Co-Authors agree to the submission, license and publication of the Work on the terms of this Publication Agreement; and (ii) the Author has the authority to enter into this biding Publication Agreement on behalf of each Co-Author. The Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each Co-Author.
\\n\\nThe Author agrees to indemnify IntechOpen harmless against all liabilities, costs, expenses, damages and losses, as well as all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of, or in connection with, any breach of the agreed confirmations and warranties. This indemnity shall not apply in a situation in which a claim results from IntechOpen's negligence or willful misconduct.
\\n\\nNothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\nTERMINATION
\\n\\nIntechOpen has the right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Author and/or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Author and/or any Co-Author (being a private individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Author and/or any Co-Author (as a corporate entity) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for, or enters into, any compromise or arrangement with any of its creditors.
\\n\\nIn the event of termination, IntechOpen will notify the Author of the decision in writing.
\\n\\nIntechOpen’s DUTIES AND RIGHTS
\\n\\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen, at its discretion, agrees to publish the Work attributing it to the Author and Co-Authors.
\\n\\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen agrees to provide publishing services which include: managing editing (editorial and publishing process coordination, Author assistance); publishing software technology; language copyediting; typesetting; online publishing; hosting and web management; and abstracting and indexing services.
\\n\\nIntechOpen agrees to offer free online access to readers and use reasonable efforts to promote the Publication to relevant audiences.
\\n\\nIntechOpen is granted the authority to enforce the rights from this Publication Agreement on behalf of the Author and Co-Authors against third parties, for example in cases of plagiarism or copyright infringements. In respect of any such infringement or suspected infringement of the copyright in the Work, IntechOpen shall have absolute discretion in addressing any such infringement that is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\nIntechOpen has the right to include/use the Author and Co-Authors names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Work and has the right to contact the Author and Co-Authors until the Work is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\nMISCELLANEOUS
\\n\\nFurther Assurance: The Author shall ensure that any relevant third party, including any Co-Author, shall execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\nThird Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\nEntire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by, or on behalf of, the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (known as the "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of any fraudulent pre-contract misrepresentation or concealment.
\\n\\nWaiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\nVariation: No variation of this Publication Agreement shall have effect unless it is in writing and signed by the parties, or their duly authorized representatives.
\\n\\nSeverance: If any provision, or part-provision, of this Publication Agreement is, or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted. Any modification to, or deletion of, a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\nNo partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Author or any Co-Author, nor authorize any party to make or enter into any commitments for, or on behalf of, any other party.
\\n\\nGoverning law: This Publication Agreement and any dispute or claim, including non-contractual disputes or claims arising out of, or in connection with it, or its subject matter or formation, shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of, or in connection with, this Publication Agreement, including any non-contractual disputes or claims.
\\n\\nPolicy last updated: 2018-09-11
\\n"}]'},components:[{type:"htmlEditorComponent",content:'When submitting a manuscript, the Author is required to accept the Terms and Conditions set out in our Publication Agreement – Monographs/Compacts as follows:
\n\nCORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\nSubject to the following Article, the Author grants to IntechOpen, during the full term of copyright, and any extensions or renewals of that term, the following:
\n\nThe foregoing licenses shall survive the expiry or termination of this Publication Agreement for any reason.
\n\nThe Author, on his or her own behalf and on behalf of any of the Co-Authors, reserves the following rights in the Work but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Work as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\n\nThe Author, and any Co-Author, confirms that they are, and will remain, a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Work and all versions of it created during IntechOpen's editing process, including all published versions, is retained by the Author and any Co-Authors.
\n\nSubject to the license granted above, the Author and Co-Authors retain patent, trademark and other intellectual property rights to the Work.
\n\nAll rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the specific approval of the Author or Co-Authors.
\n\nThe Author, on his/her own behalf and on behalf of the Co-Authors, will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Work as a consequence of IntechOpen's changes to the Work arising from the translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits as determined by IntechOpen.
\n\nAUTHOR'S DUTIES
\n\nWhen distributing or re-publishing the Work, the Author agrees to credit the Monograph/Compacts as the source of first publication, as well as IntechOpen. The Author guarantees that Co-Authors will also credit the Monograph/Compacts as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Work.
\n\nThe Author agrees to:
\n\nThe Author will be held responsible for the payment of the agreed Open Access Publishing Fee before the completion of the project (Monograph/Compacts publication).
\n\nAll payments shall be due 30 days from the date of issue of the invoice. The Author or whoever is paying on behalf of the Author and Co-Authors will bear all banking and similar charges incurred.
\n\nThe Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Work worldwide for the full term of the above licenses, and shall provide to IntechOpen, at its request, the original copies of such consents for inspection or the photocopies of such consents.
\n\nThe Author shall obtain written informed consent for publication from those who might recognize themselves or be identified by others, for example from case reports or photographs.
\n\nThe Author shall respect confidentiality during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Author and Co-Authors are confidential and are intended only for the recipients. The contents of any communication may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\nAUTHOR'S WARRANTY
\n\nThe Author and Co-Authors confirm and warrant that the Work does not and will not breach any applicable law or the rights of any third party and, specifically, that the Work contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy.
\n\nThe Author and Co-Authors confirm that: (i) the Work is their original work and is not copied wholly or substantially from any other work or material or any other source; (ii) the Work has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) Authors and any applicable Co-Authors are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) Authors and any applicable Co-Authors have not assigned, and will not during the term of this Publication Agreement purport to assign, any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Author and Co-Authors also confirm and warrant that: (i) he/she has the power to enter into this Publication Agreement on his or her own behalf and on behalf of each Co-Author; and (ii) has the necessary rights and/or title in and to the Work to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licences in this Publication Agreement. If the Work was prepared jointly by the Author and Co-Authors, the Author confirms that: (i) all Co-Authors agree to the submission, license and publication of the Work on the terms of this Publication Agreement; and (ii) the Author has the authority to enter into this biding Publication Agreement on behalf of each Co-Author. The Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each Co-Author.
\n\nThe Author agrees to indemnify IntechOpen harmless against all liabilities, costs, expenses, damages and losses, as well as all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of, or in connection with, any breach of the agreed confirmations and warranties. This indemnity shall not apply in a situation in which a claim results from IntechOpen's negligence or willful misconduct.
\n\nNothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\nTERMINATION
\n\nIntechOpen has the right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Author and/or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Author and/or any Co-Author (being a private individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Author and/or any Co-Author (as a corporate entity) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for, or enters into, any compromise or arrangement with any of its creditors.
\n\nIn the event of termination, IntechOpen will notify the Author of the decision in writing.
\n\nIntechOpen’s DUTIES AND RIGHTS
\n\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen, at its discretion, agrees to publish the Work attributing it to the Author and Co-Authors.
\n\nUnless prevented from doing so by events beyond its reasonable control, IntechOpen agrees to provide publishing services which include: managing editing (editorial and publishing process coordination, Author assistance); publishing software technology; language copyediting; typesetting; online publishing; hosting and web management; and abstracting and indexing services.
\n\nIntechOpen agrees to offer free online access to readers and use reasonable efforts to promote the Publication to relevant audiences.
\n\nIntechOpen is granted the authority to enforce the rights from this Publication Agreement on behalf of the Author and Co-Authors against third parties, for example in cases of plagiarism or copyright infringements. In respect of any such infringement or suspected infringement of the copyright in the Work, IntechOpen shall have absolute discretion in addressing any such infringement that is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\nIntechOpen has the right to include/use the Author and Co-Authors names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Work and has the right to contact the Author and Co-Authors until the Work is publicly available on any platform owned and/or operated by IntechOpen.
\n\nMISCELLANEOUS
\n\nFurther Assurance: The Author shall ensure that any relevant third party, including any Co-Author, shall execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\nThird Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\nEntire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by, or on behalf of, the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (known as the "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of any fraudulent pre-contract misrepresentation or concealment.
\n\nWaiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\nVariation: No variation of this Publication Agreement shall have effect unless it is in writing and signed by the parties, or their duly authorized representatives.
\n\nSeverance: If any provision, or part-provision, of this Publication Agreement is, or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted. Any modification to, or deletion of, a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\nNo partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Author or any Co-Author, nor authorize any party to make or enter into any commitments for, or on behalf of, any other party.
\n\nGoverning law: This Publication Agreement and any dispute or claim, including non-contractual disputes or claims arising out of, or in connection with it, or its subject matter or formation, shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of, or in connection with, this Publication Agreement, including any non-contractual disputes or claims.
\n\nPolicy last updated: 2018-09-11
\n'}]},successStories:{items:[]},authorsAndEditors:{filterParams:{},profiles:[{id:"396",title:"Dr.",name:"Vedran",middleName:null,surname:"Kordic",slug:"vedran-kordic",fullName:"Vedran Kordic",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/396/images/7281_n.png",biography:"After obtaining his Master's degree in Mechanical Engineering he continued his education at the Vienna University of Technology where he obtained his PhD degree in 2004. He worked as a researcher at the Automation and Control Institute, Faculty of Electrical Engineering, Vienna University of Technology until 2008. His studies in robotics lead him not only to a PhD degree but also inspired him to co-found and build the International Journal of Advanced Robotic Systems - world's first Open Access journal in the field of robotics.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"441",title:"Ph.D.",name:"Jaekyu",middleName:null,surname:"Park",slug:"jaekyu-park",fullName:"Jaekyu Park",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/441/images/1881_n.jpg",biography:null,institutionString:null,institution:{name:"LG Corporation (South Korea)",country:{name:"Korea, South"}}},{id:"465",title:"Dr.",name:"Christian",middleName:null,surname:"Martens",slug:"christian-martens",fullName:"Christian Martens",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Rheinmetall (Germany)",country:{name:"Germany"}}},{id:"479",title:"Dr.",name:"Valentina",middleName:null,surname:"Colla",slug:"valentina-colla",fullName:"Valentina Colla",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/479/images/358_n.jpg",biography:null,institutionString:null,institution:{name:"Sant'Anna School of Advanced Studies",country:{name:"Italy"}}},{id:"494",title:"PhD",name:"Loris",middleName:null,surname:"Nanni",slug:"loris-nanni",fullName:"Loris Nanni",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/494/images/system/494.jpg",biography:"Loris Nanni received his Master Degree cum laude on June-2002 from the University of Bologna, and the April 26th 2006 he received his Ph.D. in Computer Engineering at DEIS, University of Bologna. On September, 29th 2006 he has won a post PhD fellowship from the university of Bologna (from October 2006 to October 2008), at the competitive examination he was ranked first in the industrial engineering area. He extensively served as referee for several international journals. He is author/coauthor of more than 100 research papers. He has been involved in some projects supported by MURST and European Community. His research interests include pattern recognition, bioinformatics, and biometric systems (fingerprint classification and recognition, signature verification, face recognition).",institutionString:null,institution:null},{id:"496",title:"Dr.",name:"Carlos",middleName:null,surname:"Leon",slug:"carlos-leon",fullName:"Carlos Leon",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Seville",country:{name:"Spain"}}},{id:"512",title:"Dr.",name:"Dayang",middleName:null,surname:"Jawawi",slug:"dayang-jawawi",fullName:"Dayang Jawawi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Technology Malaysia",country:{name:"Malaysia"}}},{id:"528",title:"Dr.",name:"Kresimir",middleName:null,surname:"Delac",slug:"kresimir-delac",fullName:"Kresimir Delac",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/528/images/system/528.jpg",biography:"K. Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. His current research interests are in the fields of intelligent control and robotics.",institutionString:null,institution:{name:"Technical University of Sofia",country:{name:"Bulgaria"}}},{id:"585",title:"Prof.",name:"Munir",middleName:null,surname:"Merdan",slug:"munir-merdan",fullName:"Munir Merdan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/585/images/system/585.jpg",biography:"Munir Merdan received the M.Sc. degree in mechanical engineering from the Technical University of Sarajevo, Bosnia and Herzegovina, in 2001, and the Ph.D. degree in electrical engineering from the Vienna University of Technology, Vienna, Austria, in 2009.Since 2005, he has been at the Automation and Control Institute, Vienna University of Technology, where he is currently a Senior Researcher. His research interests include the application of agent technology for achieving agile control in the manufacturing environment.",institutionString:null,institution:null},{id:"605",title:"Prof",name:"Dil",middleName:null,surname:"Hussain",slug:"dil-hussain",fullName:"Dil Hussain",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/605/images/system/605.jpg",biography:"Dr. Dil Muhammad Akbar Hussain is a professor of Electronics Engineering & Computer Science at the Department of Energy Technology, Aalborg University Denmark. Professor Akbar has a Master degree in Digital Electronics from Govt. College University, Lahore Pakistan and a P-hD degree in Control Engineering from the School of Engineering and Applied Sciences, University of Sussex United Kingdom. Aalborg University has Two Satellite Campuses, one in Copenhagen (Aalborg University Copenhagen) and the other in Esbjerg (Aalborg University Esbjerg).\n· He is a member of prestigious IEEE (Institute of Electrical and Electronics Engineers), and IAENG (International Association of Engineers) organizations. \n· He is the chief Editor of the Journal of Software Engineering.\n· He is the member of the Editorial Board of International Journal of Computer Science and Software Technology (IJCSST) and International Journal of Computer Engineering and Information Technology. \n· He is also the Editor of Communication in Computer and Information Science CCIS-20 by Springer.\n· Reviewer For Many Conferences\nHe is the lead person in making collaboration agreements between Aalborg University and many universities of Pakistan, for which the MOU’s (Memorandum of Understanding) have been signed.\nProfessor Akbar is working in Academia since 1990, he started his career as a Lab demonstrator/TA at the University of Sussex. After finishing his P. hD degree in 1992, he served in the Industry as a Scientific Officer and continued his academic career as a visiting scholar for a number of educational institutions. In 1996 he joined National University of Science & Technology Pakistan (NUST) as an Associate Professor; NUST is one of the top few universities in Pakistan. In 1999 he joined an International Company Lineo Inc, Canada as Manager Compiler Group, where he headed the group for developing Compiler Tool Chain and Porting of Operating Systems for the BLACKfin processor. The processor development was a joint venture by Intel and Analog Devices. In 2002 Lineo Inc., was taken over by another company, so he joined Aalborg University Denmark as an Assistant Professor.\nProfessor Akbar has truly a multi-disciplined career and he continued his legacy and making progress in many areas of his interests both in teaching and research. 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Toward this end, we applied EWMA chart to the output residuals obtained from MSPLS model. 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We first introduce a general framework and several conventional models for functional data, including the functional linear model, penalized regression splines, and the spatial temporal model. However, in engineering practice, a naive mathematical modeling of functional response may fail due to the lack of expressing the underlying physical mechanism. We propose a series of quasiphysical models to handle the functional response. A motivating example of metamaterial design is thoroughly discussed to demonstrate the idea of quasiphysical models. In real applications, various uncertainties have to be taken into account, such as that of the permittivity or permeability of the substrate of the metamaterial. For the propagation of uncertainty, simulation‐based methods are discussed. A Bayesian framework is presented to deal with the model calibration in the case of functional response. Experimental results illustrate the efficiency of the proposed method.",book:{id:"5832",slug:"uncertainty-quantification-and-model-calibration",title:"Uncertainty Quantification and Model Calibration",fullTitle:"Uncertainty Quantification and Model Calibration"},signatures:"Xiao Guo, Yang He, Binbin Zhu, Yang Yang, Ke Deng, Ruopeng Liu\nand Chunlin Ji",authors:[{id:"198216",title:"Dr.",name:"Chunlin",middleName:null,surname:"Ji",slug:"chunlin-ji",fullName:"Chunlin Ji"},{id:"199075",title:"Dr.",name:"Xiao",middleName:null,surname:"Guo",slug:"xiao-guo",fullName:"Xiao Guo"}]}],mostDownloadedChaptersLast30Days:[{id:"54982",title:"Polynomial Chaos Expansion for Probabilistic Uncertainty Propagation",slug:"polynomial-chaos-expansion-for-probabilistic-uncertainty-propagation",totalDownloads:2869,totalCrossrefCites:6,totalDimensionsCites:11,abstract:"Uncertainty propagation (UP) methods are of great importance to design optimization under uncertainty. 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In addition, comprehensive comparisons are made to explore the relative merits of the most commonly used PCE approaches in the literature to help designers to choose more suitable PCE techniques in probabilistic design optimization.",book:{id:"5832",slug:"uncertainty-quantification-and-model-calibration",title:"Uncertainty Quantification and Model Calibration",fullTitle:"Uncertainty Quantification and Model Calibration"},signatures:"Shuxing Yang, Fenfen Xiong and Fenggang Wang",authors:[{id:"200594",title:"Dr.",name:"Fenfen",middleName:null,surname:"Xiong",slug:"fenfen-xiong",fullName:"Fenfen Xiong"},{id:"200601",title:"Prof.",name:"Shuxing",middleName:null,surname:"Yang",slug:"shuxing-yang",fullName:"Shuxing Yang"},{id:"205382",title:"Mr.",name:"Fenggang",middleName:null,surname:"Wang",slug:"fenggang-wang",fullName:"Fenggang Wang"}]},{id:"54755",title:"Fitting Models to Data: Residual Analysis, a Primer",slug:"fitting-models-to-data-residual-analysis-a-primer",totalDownloads:2503,totalCrossrefCites:10,totalDimensionsCites:16,abstract:"The aim of this chapter is to show checking the underlying assumptions (the errors are independent, have a zero mean, a constant variance and follows a normal distribution) in a regression analysis, mainly fitting a straight‐line model to experimental data, via the residual plots. 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Several examples taken from scientific journals and monographs are selected dealing with linearity, calibration, heteroscedastic data, errors in the model, transforming data, time‐order analysis and non‐linear calibration curves.",book:{id:"5832",slug:"uncertainty-quantification-and-model-calibration",title:"Uncertainty Quantification and Model Calibration",fullTitle:"Uncertainty Quantification and Model Calibration"},signatures:"Julia Martin, David Daffos Ruiz de Adana and Agustin G. Asuero",authors:[{id:"190870",title:"Dr.",name:"Agustín G.",middleName:null,surname:"Asuero",slug:"agustin-g.-asuero",fullName:"Agustín G. 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However, results of molecular dynamics simulations are often associated with errors as compared with experimental observations. These errors come from a variety of sources, including inaccuracy of interatomic potentials, short length and time scales, idealized problem description and statistical uncertainties of MD simulations themselves. This chapter specifically devotes to the statistical uncertainties of MD simulations. In particular, methods to quantify and reduce such statistical uncertainties are demonstrated using a variety of exemplar cases, including calculations of finite temperature static properties such as lattice constants, cohesive energies, elastic constants, dislocation energies, thermal conductivities, surface segregation and calculations of kinetic properties such as diffusion parameters. We also demonstrate that when the statistical uncertainties are reduced to near zero, MD can be used to validate and improve widely used theories.",book:{id:"5832",slug:"uncertainty-quantification-and-model-calibration",title:"Uncertainty Quantification and Model Calibration",fullTitle:"Uncertainty Quantification and Model Calibration"},signatures:"Xiaowang Zhou and Stephen M. Foiles",authors:[{id:"201277",title:"Dr.",name:"Xiaowang",middleName:null,surname:"Zhou",slug:"xiaowang-zhou",fullName:"Xiaowang Zhou"},{id:"205437",title:"Dr.",name:"Stephen M.",middleName:null,surname:"Foiles",slug:"stephen-m.-foiles",fullName:"Stephen M. Foiles"}]},{id:"54841",title:"State‐of‐the‐Art Nonprobabilistic Finite Element Analyses",slug:"state-of-the-art-nonprobabilistic-finite-element-analyses",totalDownloads:1647,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"The finite element analysis of a mechanical system is conventionally performed in the context of deterministic inputs. However, uncertainties associated with material properties, geometric dimensions, subjective experiences, boundary conditions, and external loads are ubiquitous in engineering applications. The most popular techniques to handle these uncertain parameters are the probabilistic methods, in which uncertainties are modeled as random variables or stochastic processes based on a large amount of statistical information on each uncertain parameter. Nevertheless, subjective results could be obtained if insufficient information unavailable and nonprobabilistic methods can be alternatively employed, which has led to elegant procedures for the nonprobabilistic finite element analysis. In this chapter, each nonprobabilistic finite element analysis method can be decomposed as two individual parts, i.e., the core algorithm and preprocessing procedure. In this context, four types of algorithms and two typical preprocessing procedures as well as their effectiveness were described in detail, based on which novel hybrid algorithms can be conceived for the specific problems and the future work in this research field can be fostered.",book:{id:"5832",slug:"uncertainty-quantification-and-model-calibration",title:"Uncertainty Quantification and Model Calibration",fullTitle:"Uncertainty Quantification and Model Calibration"},signatures:"Wang Lei, Qiu Zhiping and Zheng Yuning",authors:[{id:"196882",title:"Prof.",name:"Zhiping",middleName:null,surname:"Qiu",slug:"zhiping-qiu",fullName:"Zhiping Qiu"},{id:"198421",title:"Dr.",name:"Lei",middleName:null,surname:"Wang",slug:"lei-wang",fullName:"Lei Wang"},{id:"204754",title:"Dr.",name:"Yuning",middleName:null,surname:"Zheng",slug:"yuning-zheng",fullName:"Yuning Zheng"}]},{id:"55556",title:"An Improved Wavelet‐Based Multivariable Fault Detection Scheme",slug:"an-improved-wavelet-based-multivariable-fault-detection-scheme",totalDownloads:1542,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"Data observed from environmental and engineering processes are usually noisy and correlated in time, which makes the fault detection more difficult as the presence of noise degrades fault detection quality. 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It is shown through simulated distillation column data the significant improvement in fault detection can be obtained by using the proposed methods as compared to the use of the conventional partial least square (PLS)‐based Q and EWMA methods and MSPLS‐based Q method.",book:{id:"5832",slug:"uncertainty-quantification-and-model-calibration",title:"Uncertainty Quantification and Model Calibration",fullTitle:"Uncertainty Quantification and Model Calibration"},signatures:"Fouzi Harrou, Ying Sun and Muddu Madakyaru",authors:[{id:"197090",title:"Dr.",name:"Fouzi",middleName:null,surname:"Harrou",slug:"fouzi-harrou",fullName:"Fouzi Harrou"}]}],onlineFirstChaptersFilter:{topicId:"613",limit:6,offset:0},onlineFirstChaptersCollection:[{id:"82166",title:"Evaluation of Principal Component Analysis Variants to Assess Their Suitability for Mobile Malware Detection",slug:"evaluation-of-principal-component-analysis-variants-to-assess-their-suitability-for-mobile-malware-d",totalDownloads:10,totalDimensionsCites:0,doi:"10.5772/intechopen.105418",abstract:"Principal component analysis (PCA) is an unsupervised machine learning algorithm that plays a vital role in reducing the dimensions of the data in building an appropriate machine learning model. It is a statistical process that transforms the data containing correlated features into a set of uncorrelated features with the help of orthogonal transformations. Unsupervised machine learning is a concept of self-learning method that involves unlabelled data to identify hidden patterns. PCA converts the data features from a high dimensional space into a low dimensional space. PCA also acts as a feature extraction method since it transforms the ‘n’ number of features into ‘m’ number of principal components (PCs; m < n). Mobile Malware is increasing tremendously in the digital era due to the growth of android mobile users and android applications. Some of the mobile malware are viruses, Trojan horses, worms, adware, spyware, ransomware, riskware, banking malware, SMS malware, keylogger, and many more. To automate the process of detecting mobile malware without human intervention, machine learning methods are applied to discover the malware more precisely. Specifically, unsupervised machine learning helps to uncover the hidden patterns to detect anomalies in the data. In discovering hidden patterns of malware, PCA is an important dimensionality reduction technique that can be applied to transform the features into PCs containing important feature values. So, by implementing PCA, the correlated features are transformed into uncorrelated features automatically to explore the anomalies in the data effectively. This book chapter explains all the variants of the PCA, including all linear and non-linear methods of PCA and their suitability in applying to mobile malware detection. A case study on mobile malware detection with variants of PCA using machine learning techniques in CICMalDroid_2020 dataset has been experimented. Based on the experimental results, for the given dataset, normal PCA is suitable to detect the malware data points and forms an optimal cluster.",book:{id:"11201",title:"Advances in Principal Component Analysis",coverURL:"https://cdn.intechopen.com/books/images_new/11201.jpg"},signatures:"Padmavathi Ganapathi, Shanmugapriya Dhathathri and Roshni Arumugam"},{id:"81645",title:"Determining an Adequate Number of Principal Components",slug:"determining-an-adequate-number-of-principal-components",totalDownloads:11,totalDimensionsCites:0,doi:"10.5772/intechopen.104534",abstract:"The problem of choosing the number of PCs to retain is analyzed in the context of model selection, using so-called model selection criteria (MSCs). For a prespecified set of models, indexed by k=1,2,…,K, these model selection criteria (MSCs) take the form MSCk=nLLk+anmk, where, for model k,LLk is the maximum log likelihood, mk is the number of independent parameters, and the constant an is an=lnn for BIC and an=2 for AIC. The maximum log likelihood LLk is achieved by using the maximum likelihood estimates (MLEs) of the parameters. In Gaussian models, LLk involves the logarithm of the mean squared error (MSE). The main contribution of this chapter is to show how to best use BIC to choose the number of PCs, and to compare these results to ad hoc procedures that have been used. Findings include the following. These are stated as they apply to the eigenvalues of the correlation matrix, which are between 0 and p and have an average of 1. For considering an additional PCk + 1, with AIC, inclusion of the additional PCk + 1 is justified if the corresponding eigenvalue λk+1 is greater than exp−2/n. For BIC, the inclusion of an additional PCk + 1 is justified if λk+1>n1/n, which tends to 1 for large n. Therefore, this is in approximate agreement with the average eigenvalue rule for correlation matrices, stating that one should retain dimensions with eigenvalues larger than 1.",book:{id:"11201",title:"Advances in Principal Component Analysis",coverURL:"https://cdn.intechopen.com/books/images_new/11201.jpg"},signatures:"Stanley L. Sclove"},{id:"81542",title:"On the Use of Modified Winsorization with Graphical Diagnostic for Obtaining a Statistically Optimal Classification Accuracy in Predictive Discriminant Analysis",slug:"on-the-use-of-modified-winsorization-with-graphical-diagnostic-for-obtaining-a-statistically-optimal",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.104539",abstract:"In predictive discriminant analysis (PDA), the classification accuracy is only statistically optimal if each group sample is normally distributed with different group means, and each predictor variance is similar between the groups. This can be achieved by accounting for homogeneity of variances between the groups using the modified winsorization with graphical diagnostic (MW-GD) method. The MW-GD method involves the identification and removal of legitimate contaminants in a training sample with the aim of obtaining a true optimal training sample that can be used to build a predictive discriminant function (PDF) that will yield a statistically optimal classification accuracy. However, the use of this method is yet to receive significant attention in PDA. An alternative statistical interpretation of the graphical diagnostic information associated with the method when confronted with the challenge of differentiating between a variable shape in the groups of the 2-D area plot remains a problem to be resolved. Therefore, this paper provides a more comprehensive analysis of the idea and concept of the MW-GD method, as well as proposed an alternative statistical interpretation of the informative graphical diagnostic associated with the method when confronted with the challenge of differentiating between a variable shape in the groups of the 2-D area plot.",book:{id:"11201",title:"Advances in Principal Component Analysis",coverURL:"https://cdn.intechopen.com/books/images_new/11201.jpg"},signatures:"Augustine Iduseri"},{id:"81460",title:"Spatial Principal Component Analysis of Head-Related Transfer Functions and Its Domain Dependency",slug:"spatial-principal-component-analysis-of-head-related-transfer-functions-and-its-domain-dependency",totalDownloads:15,totalDimensionsCites:0,doi:"10.5772/intechopen.104449",abstract:"In this chapter, the Principal Component Analysis (PCA) was adopted to spatial variation of Head-Related Transfer Function (HRTF) or its corresponding inverse Fourier Transform, called Head-Related Impulse Response (HRIR), in order to compactly represent their spatial variation. This is called the Spatial PCA (SPCA). The SPCA was carried out for a database of HRTFs in all directions by selecting the domain as one of the HRIRs, the complex HRTFs, the frequency amplitudes of HRTFs, log-amplitudes of HRTFs, and complex logarithm of HRTFs. The minimum phase approximation was incorporated for the frequency amplitudes and log-amplitudes of HRTFs. Comparison of the accuracies in both time and frequency domains taking into account their influence on subjective evaluation showed that the log-amplitudes and complex logarithm of HRTFs are suitable for the SPCA of HRTFs.",book:{id:"11201",title:"Advances in Principal Component Analysis",coverURL:"https://cdn.intechopen.com/books/images_new/11201.jpg"},signatures:"Shouichi Takane"},{id:"81407",title:"Space-Time-Parameter PCA for Data-Driven Modeling with Application to Bioengineering",slug:"space-time-parameter-pca-for-data-driven-modeling-with-application-to-bioengineering",totalDownloads:28,totalDimensionsCites:0,doi:"10.5772/intechopen.103756",abstract:"Principal component analysis is a recognized powerful and practical method in statistics and data science. It can also be used in modeling as a dimensionality reduction tool to achieve low-order models of complex multiphysics or engineering systems. Model-order reduction (MOR) methodologies today are an important topic for engineering design and analysis. Design space exploration or accelerated numerical optimization for example are made easier by the use of reduced-order models. In this chapter, we will talk about the use of higher-order singular value decompositions (HOSVD) applied to spatiotemporal problems that are parameterized by a set of design variables or physical parameters. Here we consider a data-driven reduced order modeling based on a design of computer experiment: from high-dimensional computational results returned by high-fidelity solvers (e.g. finite element ones), the HOSVD allows us to determine spatial, time and parameters principal components. The dynamics of the system can then be retrieved by identifying the low-order discrete dynamical system. As application, we will consider the dynamics of deformable capsules flowing into microchannels. The study of such fluid-structure interaction problems is motivated by the use of microcapsules as innovative drug delivery carriers through blood vessels.",book:{id:"11201",title:"Advances in Principal Component Analysis",coverURL:"https://cdn.intechopen.com/books/images_new/11201.jpg"},signatures:"Florian De Vuyst, Claire Dupont and Anne-Virginie Salsac"},{id:"81414",title:"Prediction Analysis Based on Logistic Regression Modelling",slug:"prediction-analysis-based-on-logistic-regression-modelling",totalDownloads:14,totalDimensionsCites:0,doi:"10.5772/intechopen.103090",abstract:"The chapter aims to show an application of logistic regression modelling for prediction analysis in the offshore industry. The different variables shown in dynamic positioning incident reports are analysed and processed using logistic regression modelling. The results of the models are then analysed, showing which data influence the loss of positioning and human errors and how the model can be interpreted. Afterwards, and based on the obtained models, operational limits can be proposed to reduce downtimes and thus improve the safety of the operations and the productivity of the offshore operations when using dynamic positioning systems.",book:{id:"11201",title:"Advances in Principal Component Analysis",coverURL:"https://cdn.intechopen.com/books/images_new/11201.jpg"},signatures:"Zaloa Sanchez-Varela"}],onlineFirstChaptersTotal:12},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:11,numberOfPublishedChapters:91,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:108,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:332,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:11,numberOfPublishedChapters:142,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:124,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:22,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:12,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. 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",coverUrl:"https://cdn.intechopen.com/series/covers/23.jpg",latestPublicationDate:"August 17th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"280770",title:"Dr.",name:"Katherine K.M.",middleName:null,surname:"Stavropoulos",slug:"katherine-k.m.-stavropoulos",fullName:"Katherine K.M. Stavropoulos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRdFuQAK/Profile_Picture_2022-05-24T09:03:48.jpg",biography:"Katherine Stavropoulos received her BA in Psychology from Trinity College, in Connecticut, USA and her Ph.D. in Experimental Psychology from the University of California, San Diego. She completed her postdoctoral work at the Yale Child Study Center with Dr. James McPartland. Dr. Stavropoulos’ doctoral dissertation explored neural correlates of reward anticipation to social versus nonsocial stimuli in children with and without autism spectrum disorders (ASD). She has been a faculty member at the University of California, Riverside in the School of Education since 2016. Her research focuses on translational studies to explore the reward system in ASD, as well as how anxiety contributes to social challenges in ASD. She also investigates how behavioral interventions affect neural activity, behavior, and school performance in children with ASD. She is also involved in the diagnosis of children with ASD and is a licensed clinical psychologist in California. She is the Assistant Director of the SEARCH Center at UCR and is a faculty member in the Graduate Program in Neuroscience.",institutionString:null,institution:{name:"University of California, Riverside",institutionURL:null,country:{name:"United States of America"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:2,paginationItems:[{id:"89",title:"Education",coverUrl:"https://cdn.intechopen.com/series_topics/covers/89.jpg",isOpenForSubmission:!1,editor:{id:"260066",title:"Associate Prof.",name:"Michail",middleName:null,surname:"Kalogiannakis",slug:"michail-kalogiannakis",fullName:"Michail Kalogiannakis",profilePictureURL:"https://mts.intechopen.com/storage/users/260066/images/system/260066.jpg",biography:"Michail Kalogiannakis is an Associate Professor of the Department of Preschool Education, University of Crete, and an Associate Tutor at School of Humanities at the Hellenic Open University. He graduated from the Physics Department of the University of Crete and continued his post-graduate studies at the University Paris 7-Denis Diderot (D.E.A. in Didactic of Physics), University Paris 5-René Descartes-Sorbonne (D.E.A. in Science Education) and received his Ph.D. degree at the University Paris 5-René Descartes-Sorbonne (PhD in Science Education). His research interests include science education in early childhood, science teaching and learning, e-learning, the use of ICT in science education, games simulations, and mobile learning. He has published over 120 articles in international conferences and journals and has served on the program committees of numerous international conferences.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorTwo:{id:"422488",title:"Dr.",name:"Maria",middleName:null,surname:"Ampartzaki",slug:"maria-ampartzaki",fullName:"Maria Ampartzaki",profilePictureURL:"https://mts.intechopen.com/storage/users/422488/images/system/422488.jpg",biography:"Dr Maria Ampartzaki is an Assistant Professor in Early Childhood Education in the Department of Preschool Education at the University of Crete. Her research interests include ICT in education, science education in the early years, inquiry-based and art-based learning, teachers’ professional development, action research, and the Pedagogy of Multiliteracies, among others. She has run and participated in several funded and non-funded projects on the teaching of Science, Social Sciences, and ICT in education. She also has the experience of participating in five Erasmus+ projects.",institutionString:"University of Crete",institution:{name:"University of Crete",institutionURL:null,country:{name:"Greece"}}},editorThree:null},{id:"90",title:"Human Development",coverUrl:"https://cdn.intechopen.com/series_topics/covers/90.jpg",isOpenForSubmission:!0,editor:{id:"191040",title:"Dr.",name:"Tal",middleName:null,surname:"Dotan Ben-Soussan",slug:"tal-dotan-ben-soussan",fullName:"Tal Dotan Ben-Soussan",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBf1QAG/Profile_Picture_2022-03-18T07:56:11.jpg",biography:"Tal Dotan Ben-Soussan, Ph.D., is the director of the Research Institute for Neuroscience, Education and Didactics (RINED) – Paoletti Foundation. Ben-Soussan leads international studies on training and neuroplasticity from neurophysiological and psychobiological perspectives. As a neuroscientist and bio-psychologist, she has published numerous articles on neuroplasticity, movement and meditation. She acts as an editor and reviewer in several renowned journals and coordinates international conferences integrating theoretical, methodological and practical approaches on various topics, such as silence, logics and neuro-education. She lives in Assisi, Italy.",institutionString:"Research Institute for Neuroscience, Education and Didactics, Patrizio Paoletti Foundation",institution:null},editorTwo:null,editorThree:null}]},overviewPageOFChapters:{paginationCount:12,paginationItems:[{id:"83113",title:"Agoraphobic Dispositions towards Action Research: Teacher Education Students’ Perceptions and Experiences",doi:"10.5772/intechopen.106188",signatures:"Davison Zireva",slug:"agoraphobic-dispositions-towards-action-research-teacher-education-students-perceptions-and-experien",totalDownloads:1,totalCrossrefCites:null,totalDimensionsCites:0,authors:[{name:"Davison",surname:"Zireva"}],book:{title:"Active Learning - Research and Practice for STEAM and social sciences education",coverURL:"https://cdn.intechopen.com/books/images_new/11481.jpg",subseries:{id:"89",title:"Education"}}},{id:"83053",title:"Apologies in L2 French in Canadian Context",doi:"10.5772/intechopen.106557",signatures:"Bernard Mulo Farenkia",slug:"apologies-in-l2-french-in-canadian-context",totalDownloads:0,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Bernard",surname:"Mulo Farenkia"}],book:{title:"Second Language Acquisition - Learning Theories and Recent Approaches",coverURL:"https://cdn.intechopen.com/books/images_new/11480.jpg",subseries:{id:"89",title:"Education"}}},{id:"82903",title:"Walking Accessibility to Primary Healthcare Services: An Inequity Factor for Olders in the Lisbon Metropolitan Area (Portugal)",doi:"10.5772/intechopen.106265",signatures:"Eduarda Marques da Costa, Ana Louro, Nuno Marques da Costa, Mariana Dias and Marcela Barata",slug:"walking-accessibility-to-primary-healthcare-services-an-inequity-factor-for-olders-in-the-lisbon-met",totalDownloads:4,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Social Aspects of Ageing - Selected Challenges, Analyses, and Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11479.jpg",subseries:{id:"90",title:"Human Development"}}},{id:"82622",title:"Contemporary Geographical Gerontology: Reconciling Space and Place in Population Ageing",doi:"10.5772/intechopen.105863",signatures:"Hamish Robertson",slug:"contemporary-geographical-gerontology-reconciling-space-and-place-in-population-ageing",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:[{name:"Hamish",surname:"Robertson"}],book:{title:"Social Aspects of Ageing - Selected Challenges, Analyses, and Solutions",coverURL:"https://cdn.intechopen.com/books/images_new/11479.jpg",subseries:{id:"90",title:"Human Development"}}}]},overviewPagePublishedBooks:{paginationCount:0,paginationItems:[]},openForSubmissionBooks:{paginationCount:1,paginationItems:[{id:"11568",title:"Staphylococcal Infections - Recent Advances and Perspectives",coverURL:"https://cdn.intechopen.com/books/images_new/11568.jpg",hash:"92c881664d1921c7f2d0fee34b78cd08",secondStepPassed:!0,currentStepOfPublishingProcess:3,submissionDeadline:"July 8th 2022",isOpenForSubmission:!0,editors:[{id:"59719",title:"Dr.",name:"Jaime",surname:"Bustos-Martínez",slug:"jaime-bustos-martinez",fullName:"Jaime Bustos-Martínez"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},onlineFirstChapters:{paginationCount:21,paginationItems:[{id:"83000",title:"Purine and Pyrimidine Pathways as Antimalarial Targets",doi:"10.5772/intechopen.106468",signatures:"Yacoba V.T. 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He previously worked as a post-doctoral fellow at the Ben-Gurion University of Negev, Israel; University of the Free State, South Africa; and Central University of Technology Bloemfontein, South Africa. He obtained his Ph.D. in Organic Chemistry from Nagaoka University of Technology, Japan. He has published more than seventy-four journal articles and attended several national and international conferences as speaker and chair. Dr. Kendrekar has received many international awards. He has several funded projects, namely, anti-malaria drug development, MRSA, and SARS-CoV-2 activity of curcumin and its formulations. He has filed four patents in collaboration with the University of Central Lancashire and Mayo Clinic Infectious Diseases. His present research includes organic synthesis, drug discovery and development, biochemistry, nanoscience, and nanotechnology.",institutionString:"Visiting Scientist at Lipid Nanostructures Laboratory, Centre for Smart Materials, School of Natural Sciences, University of Central Lancashire",institution:null},{id:"428125",title:"Dr.",name:"Vinayak",middleName:null,surname:"Adimule",slug:"vinayak-adimule",fullName:"Vinayak Adimule",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/428125/images/system/428125.jpg",biography:"Dr. Vinayak Adimule, MSc, Ph.D., is a professor and dean of R&D, Angadi Institute of Technology and Management, India. He has 15 years of research experience as a senior research scientist and associate research scientist in R&D organizations. He has published more than fifty research articles as well as several book chapters. He has two Indian patents and two international patents to his credit. Dr. Adimule has attended, chaired, and presented papers at national and international conferences. He is a guest editor for Topics in Catalysis and other journals. He is also an editorial board member, life member, and associate member for many international societies and research institutions. His research interests include nanoelectronics, material chemistry, artificial intelligence, sensors and actuators, bio-nanomaterials, and medicinal chemistry.",institutionString:"Angadi Institute of Technology and Management",institution:null},{id:"284317",title:"Prof.",name:"Kantharaju",middleName:null,surname:"Kamanna",slug:"kantharaju-kamanna",fullName:"Kantharaju Kamanna",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/284317/images/21050_n.jpg",biography:"Prof. K. Kantharaju has received Bachelor of science (PCM), master of science (Organic Chemistry) and Doctor of Philosophy in Chemistry from Bangalore University. He worked as a Executive Research & Development @ Cadila Pharmaceuticals Ltd, Ahmedabad. He received DBT-postdoc fellow @ Molecular Biophysics Unit, Indian Institute of Science, Bangalore under the supervision of Prof. P. Balaram, later he moved to NIH-postdoc researcher at Drexel University College of Medicine, Philadelphia, USA, after his return from postdoc joined NITK-Surthakal as a Adhoc faculty at department of chemistry. Since from August 2013 working as a Associate Professor, and in 2016 promoted to Profeesor in the School of Basic Sciences: Department of Chemistry and having 20 years of teaching and research experiences.",institutionString:null,institution:{name:"Rani Channamma University, Belagavi",country:{name:"India"}}},{id:"158492",title:"Prof.",name:"Yusuf",middleName:null,surname:"Tutar",slug:"yusuf-tutar",fullName:"Yusuf Tutar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/158492/images/system/158492.jpeg",biography:"Prof. Dr. Yusuf Tutar conducts his research at the Hamidiye Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences, Division of Biochemistry, University of Health Sciences, Turkey. He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a scientist and Principal Investigator at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering the lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via artificial intelligence-based analyses of exosomal Raman signatures. Dr. Paul also works on spatial multiplex immunofluorescence-based tissue mapping to understand the immune repertoire in lung cancer. Dr. Paul has published in more than sixty-five peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award and the 2022 AAISCR-R Vijayalaxmi Award for Innovative Cancer Research. He is a senior member of the Institute of Electrical and Electronics Engineers (IEEE) and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"9",type:"subseries",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11405,editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",slug:"luis-villarreal-gomez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",biography:"Dr. Luis Villarreal is a research professor from the Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana, Baja California, México. Dr. Villarreal is the editor in chief and founder of the Revista de Ciencias Tecnológicas (RECIT) (https://recit.uabc.mx/) and is a member of several editorial and reviewer boards for numerous international journals. He has published more than thirty international papers and reviewed more than ninety-two manuscripts. His research interests include biomaterials, nanomaterials, bioengineering, biosensors, drug delivery systems, and tissue engineering.",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,series:{id:"7",title:"Biomedical Engineering",doi:"10.5772/intechopen.71985",issn:"2631-5343"},editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",slug:"cecilia-cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",slug:"gil-goncalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",slug:"johann-f.-osma",fullName:"Johann F. 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