Magnitude frequency response error comparison.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7566",leadTitle:null,fullTitle:"Gene Expression and Control",title:"Gene Expression and Control",subtitle:null,reviewType:"peer-reviewed",abstract:'Transcription is the most fundamental nuclear event, by which the information of nucleotide sequences on DNA is transcribed into RNA by multiple proteins, including RNA polymerases. Transcription determines the functions of proteins and the behaviour of cells, appropriately responding to environmental changes.This book is intended for scientists, especially those who are interested in the future prospect of gene expression and control in medicine and industry. This book consists of 9 chapters, divided into four parts. Each chapter is written by experts both in the basic and applied scientific field. A collection of articles presented by active and laboratory-based investigators provides evidence from the research, giving us a rigid platform to discuss "Gene Expression and Control."',isbn:"978-1-78985-518-0",printIsbn:"978-1-78985-517-3",pdfIsbn:"978-1-83962-113-0",doi:"10.5772/intechopen.76958",price:119,priceEur:129,priceUsd:155,slug:"gene-expression-and-control",numberOfPages:200,isOpenForSubmission:!1,isInWos:1,isInBkci:!1,hash:"d5e33453f41aee5b90bc6f6301820b89",bookSignature:"Fumiaki Uchiumi",publishedDate:"April 17th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/7566.jpg",numberOfDownloads:9804,numberOfWosCitations:2,numberOfCrossrefCitations:6,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:10,numberOfDimensionsCitationsByBook:0,hasAltmetrics:1,numberOfTotalCitations:18,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"April 11th 2018",dateEndSecondStepPublish:"May 2nd 2018",dateEndThirdStepPublish:"July 1st 2018",dateEndFourthStepPublish:"September 19th 2018",dateEndFifthStepPublish:"November 18th 2018",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"47235",title:"Dr.",name:"Fumiaki",middleName:null,surname:"Uchiumi",slug:"fumiaki-uchiumi",fullName:"Fumiaki Uchiumi",profilePictureURL:"https://mts.intechopen.com/storage/users/47235/images/system/47235.jpg",biography:"Fumiaki Uchiumi, Professor of Pharmaceutical Sciences, Tokyo University of Science, received his Bachelor\\'s degree (Chemistry) from Tokyo University of Science in 1987. In 1993, after obtaining his Ph.D. degree (Molecular Biology) from Tokyo University, he joined Professor S. Tanuma\\'s Laboratory at Tokyo University of Science as an Assistant Professor. He obtained his second Ph.D. (Pharmaceutical Science) from Tokyo University of Science in 1999 and in 2000 was promoted to the position of Lecturer at Tokyo University of Science. Professor Uchiumi then went abroad as a post-doctoral researcher for the United States-Japan Cooperative Cancer Research Program in Professor E. Fanning’s Laboratory at Vanderbilt University, 2000-2001. Professor Uchiumi was promoted to Associate Professor and then Full Professor at Tokyo University of Science in 2010 and 2016, respectively.",institutionString:"Tokyo University of Science",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"3",institution:{name:"Tokyo University of Science",institutionURL:null,country:{name:"Japan"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1050",title:"Molecular Genetics",slug:"medical-genetics-molecular-genetics"}],chapters:[{id:"63319",title:"Introductory Chapter: Gene Expression Controlling System and Its Application to Medical Sciences",doi:"10.5772/intechopen.80676",slug:"introductory-chapter-gene-expression-controlling-system-and-its-application-to-medical-sciences",totalDownloads:899,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Fumiaki Uchiumi and Masashi Asai",downloadPdfUrl:"/chapter/pdf-download/63319",previewPdfUrl:"/chapter/pdf-preview/63319",authors:[{id:"47235",title:"Dr.",name:"Fumiaki",surname:"Uchiumi",slug:"fumiaki-uchiumi",fullName:"Fumiaki Uchiumi"},{id:"265518",title:"Dr.",name:"Masashi",surname:"Asai",slug:"masashi-asai",fullName:"Masashi Asai"}],corrections:null},{id:"63916",title:"Shaping the Transcriptional Landscape through MAPK Signaling",doi:"10.5772/intechopen.80634",slug:"shaping-the-transcriptional-landscape-through-mapk-signaling",totalDownloads:1091,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"A change in the transcriptional landscape is an equilibrium-breaking event important for many biological processes. Mitogen-activated protein kinase (MAPK) signaling pathways are dedicated to sensing extracellular cues and are highly conserved across eukaryotes. Modulation of gene expression in response to the extracellular environment is one of the main mechanisms by which MAPK regulates proteome homeostasis to orchestrate adaptive responses that determine cell fate. A massive body of knowledge generated from population and single-cell analyses has led to an understanding of how MAPK pathways operate. MAPKs have thus emerged as fundamental transcriptome regulators that function through a multi-layered control of gene expression, a process often deregulated in disease, which therefore provides an attractive target for therapeutic strategies. Here, we summarize the current understanding of the mechanisms underlying MAPK-mediated gene expression in organisms ranging from yeast to mammals.",signatures:"Mariona Nadal-Ribelles, Carme Solé, Gerard Martínez-Cebrián,\nFrancesc Posas and Eulàlia de Nadal",downloadPdfUrl:"/chapter/pdf-download/63916",previewPdfUrl:"/chapter/pdf-preview/63916",authors:[{id:"256797",title:"Prof.",name:"Francesc",surname:"Posas",slug:"francesc-posas",fullName:"Francesc Posas"},{id:"256799",title:"Dr.",name:"Mariona",surname:"Nadal",slug:"mariona-nadal",fullName:"Mariona Nadal"},{id:"256800",title:"Dr.",name:"Carme",surname:"Sole",slug:"carme-sole",fullName:"Carme Sole"},{id:"256801",title:"Mr.",name:"Gerard",surname:"Martinez-Cebrian",slug:"gerard-martinez-cebrian",fullName:"Gerard Martinez-Cebrian"},{id:"256802",title:"Prof.",name:"Eulàlia",surname:"De Nadal",slug:"eulalia-de-nadal",fullName:"Eulàlia De Nadal"}],corrections:null},{id:"63812",title:"Autophagy-Related Gene Expression Changes Are Found in Pancreatic Cancer and Neurodegenerative Diseases",doi:"10.5772/intechopen.80981",slug:"autophagy-related-gene-expression-changes-are-found-in-pancreatic-cancer-and-neurodegenerative-disea",totalDownloads:1086,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Genetic alterations can cause cancer, including pancreatic cancer (PC) as well as certain neurodegenerative diseases. Our lab has recently identified genes that are modulated during pancreatic cancer liver metastasis, and some are known to have a role in neurobiology or neurodegenerative diseases. Autophagy or self-eating portrays the lysosomal-dependent degradation and recycling of protein aggregates and defective organisms in eukaryotic cells. Deregulation of autophagy as a cellular mechanism is common in neurodegenerative diseases as well as cancer and may represent a platform by which some genes can affect both disorders. This is exemplified for optineurin, which is an autophagy receptor that was found among genes with intensive modulation of expression in PC liver metastasis. Our results on this autophagy receptor draw the attention to the expression status of this and other autophagy genes in pancreatic cancer progression.",signatures:"Doaa M. Ali and Martin R. Berger",downloadPdfUrl:"/chapter/pdf-download/63812",previewPdfUrl:"/chapter/pdf-preview/63812",authors:[{id:"56407",title:"Prof.",name:"Martin",surname:"Berger",slug:"martin-berger",fullName:"Martin Berger"},{id:"256550",title:"MSc.",name:"Doaa",surname:"Ali",slug:"doaa-ali",fullName:"Doaa Ali"}],corrections:null},{id:"63320",title:"Oral Pathology: Gene Expression in Odontogenic Cysts",doi:"10.5772/intechopen.80555",slug:"oral-pathology-gene-expression-in-odontogenic-cysts",totalDownloads:1346,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Odontogenic cysts are a group of common pathological lesions of the jaw. Typically, they can be found randomly on X-rays as round benign lesions. However, some of them can behave aggressively with a tendency toward malignancy. Among odontogenic cysts with benign pathology, up to 60% of all jaw cysts are radicular cysts, which originate from root canal infection. Pathogenesis involves the interaction between osteoblasts, osteocytes, and osteoclasts as well as the expression of RANK-RANKL/OPG signaling system. Furthermore, collagenases (e.g., MMPs) are expressed in epithelial lining of the cyst. Among odontogenic cysts with potentially aggressive behavior, odontogenic keratocysts (OKCs) have a high rate of recurrence and very debatable treatment options; they can be associated with Gorlin syndrome. Keratocysts have developmental origin and show variability in their gene expression profiles. Their etiology is closely related to genetic factors, especially mutations in different members of Shh signaling pathway, including PTCH gene.",signatures:"Naida Hadziabdic and Amina Kurtovic-Kozaric",downloadPdfUrl:"/chapter/pdf-download/63320",previewPdfUrl:"/chapter/pdf-preview/63320",authors:[{id:"256275",title:"Associate Prof.",name:"Naida",surname:"Hadziabdic",slug:"naida-hadziabdic",fullName:"Naida Hadziabdic"},{id:"256276",title:"Prof.",name:"Amina",surname:"Kozaric",slug:"amina-kozaric",fullName:"Amina Kozaric"}],corrections:null},{id:"63804",title:"Data Mining Approaches for Understanding of Regulation of Expression of the Urea Cycle Genes",doi:"10.5772/intechopen.81253",slug:"data-mining-approaches-for-understanding-of-regulation-of-expression-of-the-urea-cycle-genes",totalDownloads:916,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Urea cycle converts ammonia, a waste product of protein catabolism and a neurotoxin, into non-toxic urea. Urea cycle disorders are a group of rare genetic diseases that have protein-restricted diet as a common treatment modality. Expression of urea cycle genes is regulated in concert by the dietary protein intake, but the mechanism of this regulation is not well understood. Data mining of databases such as ENCODE and Cistrome can be used to gain new information about regulatory elements, transcription factors, and epigenetic mechanisms that regulate expression of urea cycle genes. This can lead to better understanding of the common mechanism, which regulates urea cycle genes, and can generate testable hypotheses about regulation of gene expression and new treatments for urea cycle disorders.",signatures:"Ljubica Caldovic",downloadPdfUrl:"/chapter/pdf-download/63804",previewPdfUrl:"/chapter/pdf-preview/63804",authors:[{id:"257239",title:"Dr.",name:"Ljubica",surname:"Caldovic",slug:"ljubica-caldovic",fullName:"Ljubica Caldovic"}],corrections:null},{id:"63331",title:"Recent Advances about Local Gene Delivery by Ultrasound",doi:"10.5772/intechopen.80036",slug:"recent-advances-about-local-gene-delivery-by-ultrasound",totalDownloads:1104,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Gene therapy has been widely explored as a pharmacological approach, with a great potential to treat various diseases. Generally, many diseases have definite lesion’s site, especially for tumors. This feature results in a great demand on the delivery of therapeutic gene to the local lesion’s site. Ultrasound combined with microbubbles provides a promising platform to deliver gene in a spatiotemporally controlled way. Ultrasound beam can be positioned and targeted onto the deep-seated lesion’s site of diseases by an external mobile transducer. Microbubbles can serve as vehicles for carrying genetic cargo and can be destructed by ultrasound, resulting in the local release of genetic payload. Meanwhile, sonoporation effect will occur upon which the bubbles are exposed to the appropriate ultrasonic energy, producing the transient small holes on the adjacent cell membrane and thus increasing the vascular and cellular permeability. In this chapter, we will review the recent advances about local gene delivery by ultrasound.",signatures:"Zhiyi Chen, Meng Du and Fei Yan",downloadPdfUrl:"/chapter/pdf-download/63331",previewPdfUrl:"/chapter/pdf-preview/63331",authors:[{id:"254953",title:"Prof.",name:"Fei",surname:"Yan",slug:"fei-yan",fullName:"Fei Yan"},{id:"265585",title:"Dr.",name:"Meng",surname:"Du",slug:"meng-du",fullName:"Meng Du"},{id:"265586",title:"Prof.",name:"Zhiyi",surname:"Chen",slug:"zhiyi-chen",fullName:"Zhiyi Chen"}],corrections:null},{id:"65382",title:"Gene Regulation in Ruminants: A Nutritional Perspective",doi:"10.5772/intechopen.82193",slug:"gene-regulation-in-ruminants-a-nutritional-perspective",totalDownloads:1503,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"This chapter will focus on cellular regulatory programs implemented by the ruminant physiology in order to respond to external stimuli such as nutrition as well as important physiological events such as parturition. The increasing adoption of “omics” technologies and bioinformatics in nutrition and physiology in ruminant research have allowed us to delineate a clearer picture on what regulates major biological process at a molecular level such as milk synthesis and meat quality and fatty acid composition as well as pathological conditions such as ketosis, mastitis, and heat stress. The assembly of such plethora of information in a blend among nutritional research, molecular biology, and novel tools to study the response of the genome to nutrition has led to emerging disciplines such as nutritional genomics or “nutrigenomics.”",signatures:"Johan S. Osorio and Sonia J. Moisa",downloadPdfUrl:"/chapter/pdf-download/65382",previewPdfUrl:"/chapter/pdf-preview/65382",authors:[{id:"255256",title:"Dr.",name:"Johan",surname:"Osorio",slug:"johan-osorio",fullName:"Johan Osorio"},{id:"263702",title:"Dr.",name:"Sonia",surname:"Moisa",slug:"sonia-moisa",fullName:"Sonia Moisa"}],corrections:null},{id:"63286",title:"Transcriptional Initiation in Ribosomal Protein Genes in the Fission Yeast Schizosaccharomyces pombe",doi:"10.5772/intechopen.80602",slug:"transcriptional-initiation-in-ribosomal-protein-genes-in-the-fission-yeast-schizosaccharomyces-pombe",totalDownloads:805,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Transcription of class II genes in eukaryotic organisms is carried out by the multi-subunit enzyme RNA polymerase II (RNA pol II) and includes the general transcription factors and the mediator. The region inside the promoters, which recruits and specifies the transcriptional machinery, is called “core promoter” and contains sub-regions called “core promoter elements,” which are necessary for transcription initiation, where the most studied and classic element is the TATA-box. Ribosome protein gene (RPG) promoters do not possess a TATA-box (TATA-less promoters), and those, in particular, in the fission yeast Schizosaccharomyces pombe have a TATA-box analog called the HomolD-box. The transcription of RPG promoters is dependent on the RNA pol II transcription system and the HomolD-box is recognized by the transcription factor Rrn7. In this chapter, the authors will describe the general mechanisms associated to the transcription of TATA-less promoters in eukaryotic organisms and how the transcription initiation is carried out in the RPG promoters from those organisms, particularly in Schizosaccharomyces pombe. Finally, the authors will analyze the role of the HomolD-box and the transcription factor Rrn7 in the coordination of transcription initiation from RPG promoters and other ribosome-related genes and the presence of transcriptional modules in their promoters, which could be coordinated and regulated by a discrete number of transcription factors.",signatures:"Diego A. Rojas, Sandra Moreira-Ramos, Fabiola Urbina\nand Edio Maldonado",downloadPdfUrl:"/chapter/pdf-download/63286",previewPdfUrl:"/chapter/pdf-preview/63286",authors:[{id:"254282",title:"Prof.",name:"Edio",surname:"Maldonado",slug:"edio-maldonado",fullName:"Edio Maldonado"},{id:"258212",title:"Dr.",name:"Diego A.",surname:"Rojas",slug:"diego-a.-rojas",fullName:"Diego A. Rojas"},{id:"258213",title:"Dr.",name:"Sandra",surname:"Moreira-Ramos",slug:"sandra-moreira-ramos",fullName:"Sandra Moreira-Ramos"},{id:"258214",title:"Ms.",name:"Fabiola",surname:"Urbina",slug:"fabiola-urbina",fullName:"Fabiola Urbina"}],corrections:null},{id:"63905",title:"Repurposing E. coli by Engineering Quorum Sensing and Redox Genetic Circuits",doi:"10.5772/intechopen.81245",slug:"repurposing-e-coli-by-engineering-quorum-sensing-and-redox-genetic-circuits",totalDownloads:1055,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"Because cells have the extraordinary ability to sense and respond to even subtle environmental changes by intricately regulating their gene expression patterns, their behaviors can be intentionally “tuned” by altering the state of their environments in a prescribed or rational manner. Rational control of both external and internal molecular stimuli provides a basis for many biotechnological applications including the expression of foreign protein products. This is done by coordinately controlling product synthesis while retaining the cell in a productive state. Quorum sensing (QS), a molecular signaling modality that mediates cell-cell communication, autonomously facilitates both inter- and intra-species gene regulation. This process can be rewired to enable autonomously actuated, but molecularly programmed, genetic control. Recently, even electrical signals, which have long been used to control the most sophisticated of man-made devices, are now employed to alter cell signaling processes enabling computer programmed behavior, particularly in cells suitably engineered to accommodate electrical signals. By minimally engineering these genetic circuits, new applications have emerged for the repurposing of Escherichia coli, from creating innovative sensor concepts to stimulating the emerging field of electrogenetics.",signatures:"Sally Wang, Gregory F. Payne and William E. Bentley",downloadPdfUrl:"/chapter/pdf-download/63905",previewPdfUrl:"/chapter/pdf-preview/63905",authors:[{id:"255265",title:"Dr.",name:"William",surname:"Bentley",slug:"william-bentley",fullName:"William Bentley"},{id:"270082",title:"BSc.",name:"Sally",surname:"Wang",slug:"sally-wang",fullName:"Sally Wang"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6435",title:"Gene Expression and Regulation in Mammalian Cells",subtitle:"Transcription From General Aspects",isOpenForSubmission:!1,hash:"8573c44c537def5c800a0f6d4ed844d6",slug:"gene-expression-and-regulation-in-mammalian-cells-transcription-from-general-aspects",bookSignature:"Fumiaki Uchiumi",coverURL:"https://cdn.intechopen.com/books/images_new/6435.jpg",editedByType:"Edited by",editors:[{id:"47235",title:"Dr.",name:"Fumiaki",surname:"Uchiumi",slug:"fumiaki-uchiumi",fullName:"Fumiaki Uchiumi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"7204",title:"Gene Expression and Regulation in Mammalian Cells",subtitle:"Transcription Toward the Establishment of Novel Therapeutics",isOpenForSubmission:!1,hash:"10030057b2e2dee7d800ff27658c3a69",slug:"gene-expression-and-regulation-in-mammalian-cells-transcription-toward-the-establishment-of-novel-therapeutics",bookSignature:"Fumiaki Uchiumi",coverURL:"https://cdn.intechopen.com/books/images_new/7204.jpg",editedByType:"Edited by",editors:[{id:"47235",title:"Dr.",name:"Fumiaki",surname:"Uchiumi",slug:"fumiaki-uchiumi",fullName:"Fumiaki Uchiumi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1280",title:"Selected Topics in DNA Repair",subtitle:null,isOpenForSubmission:!1,hash:"bffa19c9b25bf5aaf029cc9e528916f4",slug:"selected-topics-in-dna-repair",bookSignature:"Clark C. 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He is an effective member of the Portuguese Society of Psychology, INFAD (Spain), and CITUR (Portugal), as well as an investigator of Psyche EX (Spain), a member of the chair of Entrepreneurs (Spain), and the founder and general secretary of AFIDE (Spain). He teaches Human Resources at the Polytechnic Institute of Tomar (Portugal) and a master’s course in Portugal and abroad. He is also a member of its jury commissions in Portugal and abroad, and an advisor on several scientific research papers. He has published several scientific, national, and international publications in the field of human resources, management, and psychology. 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Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},chapter:{item:{type:"chapter",id:"18566",title:"Fractional Delay Digital Filters",doi:"10.5772/31051",slug:"fractional-delay-digital-filters",body:'The chapter goal is focused to introduce the concept of fractional delay filters (FDF), as well as a concise description of most of the existing design techniques. For this purpose, several illustrative examples are presented, where each design method is implemented by MATLAB programs.
A fractional delay filter is a filter of digital type having as main function to delay the processed input signal a fractional of the sampling period time. There are several applications where such signal delay value is required, examples of such systems are: timing adjustment in all-digital receivers (symbol synchronization), conversion between arbitrary sampling frequencies, echo cancellation, speech coding and synthesis, musical instruments modelling etc. (Laakson et al., 1996).
In order to achieve the fractional delay filter function, two main frequency-domain specifications must be met by the filter. The filter magnitude frequency response must have an all-pass behaviour in a wide frequency range, as well as its phase frequency response must be linear with a fixed fractional slope through the bandwidth.
Several FIR design methods have been reported during the last two decades. There are two main design approaches: time-domain and frequency-domain design methods. In first one, the fractional delay filter coefficients are easily obtained through classical mathematical interpolation formulas, but there is a small flexibility to meet frequency-domain specifications. On the other hand, the frequency-domain methods are based on frequency optimization process, and a more frequency specification control is available. One important result of frequency-domain methods is a highly efficient implementation structure called Farrow structure, which allows online fractional value update.
The chapter is organized as follows. Next section gives the formal definition of fractional delay filter. In the third section, some design methods are briefly described. Two efficient implementation structures for wideband fractional delay filter, as well as description of recently reported design methods for such structures, are illustrated in fourth section. MATLAB designed examples and concluding remarks are presented in fifth and sixth sections, respectively.
The continuous-time output signal
where
where the delay value is given by
A signal delay value equal to a multiple of the sampling period,
In this case, the signal delay value is limited to be only
Let us introduce the FDF function using time-domain signals sketched in Fig 1. The FDF output
The fundamental design problem of a FDF is to obtain the FDF unit impulse response
where
FDF time-domain behaviour.
Simplified block diagram for a FDF.
where the delay value is given as:
Hence the ideal FDF frequency response has an all-band unity magnitude response:
and a linear frequency phase response with a constant phase delay given, respectively, by:
The main goal of all existing FDF design methods, based on a frequency design approach, is to obtain the FDF filter coefficients through approximating this ideal frequency performance.
Applying inverse discrete Fourier transform to the ideal FDF frequency response, the ideal FDF filter unit impulse response
Given a desired factional delay value, the FDF coefficients can be easily obtained with this infinite length delayed
As an illustrative example, the ideal FDF unit impulse responses for two delay values
Ideal FDF unit impulse response for
Ideal FDF unit impulse response for
The existing design methods for FIR FDF use a large range of strategies to approximate as close as possible the ideal FDF unit impulse response
A concise description of each one of these strategies is presented in the following.
The design method goal is to obtain the FDF unit impulse response
One of the criterions used for the magnitude frequency response comparison is the least squares magnitude error defined as:
The error function
where
The windowing process on the ideal unit impulse response causes not-desired effects on the FDF frequency response, in particular the Gibbs phenomenon for rectangular window (Proakis & Manolakis, 1995).
In general, the performance of a FDF obtained by truncating the
The windowed unit impulse response
FDF frequency response for D=3.65 with rectangular window,
The magnitude and phase responses of a FDF with
FDF frequency responses using windowing method for
In principle, window-based design is fast and easy. However, in practical applications it is difficult to meet a desired magnitude and phase specifications by adjusting window parameters. In order to meet a variable fractional delay specification, a real-time coefficient update method is required. This can be achieved storing the window values in memory and computing the values of the
The smallest least squares error can be achieved by defining its response only in a desired frequency band and by leaving the rest as a “don’t care” band. This can be done using a frequency-domain weighting as follows (Laakson et al., 1996):
where
In Fig. 7 are shown the FDF frequency responses designed with this method using
There is another design method based on the magnitude frequency response approach, which computes the FDF coefficients by minimizing the error function:
The solution to this optimization problem is given by the minimax method proposed by (Oetken, 1979). The obtained FDF has an equiripple pass-band magnitude response. As an illustrative example, the frequency response of an FDF designed through this minimax method is shown in Fig. 8, where
FDF frequency responses using weighted least square method for
FDF Frequency responses using minimax method for
Instead of minimizing an error function, the FDF coefficients are computed from making the error function maximally-flat at
the complex error function is defined as:
where
where
The FDF frequency responses, designed with Lagrange interpolation, with a length of 10 are shown in Fig. 9. As expected, a flat magnitude response at low frequencies is presented; a narrow bandwidth is also obtained.
FDF Frequency responses using Lagrange interpolation for
The use of this design method has three main advantages (Laakson et al., 1994): 1) the ease to compute the FDF coefficients from one closed form equation, 2) the FDF magnitude frequency response at low frequencies is completely flat, 3) a FDF with polynomial-defined coefficients allows the use of an efficient implementation structure called Farrow structure, which will be described in section 3.3.
On the other hand, there are some disadvantages to be taken into account when a Lagrange interpolation is used in FDF design: 1) the achieved bandwidth is narrow, 2) the design is made in time-domain and then any frequency information of the processed signal is not taken into account; this is a big problem because the time-domain characteristics of the signals are not usually known, and what is known is their frequency band, 3) if the polynomial order is
The use of Lagrange interpolation for FDF design is proposed in (Ging-Shing & Che-Ho, 1990, 1992), where closed form equations are presented for coefficients computing of the desired FDF filter. A combination of a multirate structure and a Lagrange-designed FDF is described in (Murphy et al., 1994), where an improved bandwidth is achieved.
The interpolation design approach is not limited only to Lagrange interpolation; some design methods using spline and parabolic interpolations were reported in (Vesma, 1995) and (Erup et al., 1993), respectively.
In this approach, the FDF design methods are based on the hybrid analogue-digital model proposed by (Ramstad, 1984), which is shown in Fig. 10. The fractional delay of the digital signal
Hybrid analogue-digital model.
An important result of this modelling is the relationship between the analogue reconstruction filer
where
This means that for a given desired fractional value, the FDF coefficients can be obtained from a designed continuous-time filter.
The design methods using this approach approximate the reconstruction filter
for
If equation (Eq. 22) is substituted in equation (Eq. 21), the resulted output signal can be expressed as:
where:
are the output samples of the
The implementation of such polynomial-based approach results in the Farrow structure, (Farrow, 1988), sketched in Fig. 11. This implementation is a highly efficient structure composed of a parallel connection of
The coefficients of each branch filter
Farrow structure.
As were pointed out previously, Lagrange interpolation has several disadvantages. A better polynomial approximation of the reconstruction filter is using a frequency-domain approach, which is achieved by optimizing the polynomial coefficients of the impulse response
There are several methods using the frequency design method (Vesma, 1999). In (Farrow, 1988) a least-mean-squares optimization is proposed in such a way that the squared error between
As were described in section 3.3, one of the most important results of the analogue-digital model in designing FDF filters is the highly efficient Farrow structure implementation, which was deduced from a piecewise approximation of the reconstruction filter through a polynomial based interpolation. The interpolation process is made as a frequency-domain optimization in most of the existing design methods.
An important design parameter is the FDF bandwidth. A wideband specification, meaning a pass-band frequency of 0.9
Some design approaches for efficient implementation structures have been proposed to reduce the number of arithmetic operations in a wideband FDF. A modified Farrow structure, reported in (Vesma & Samaraki, 1996), is an extension of the polynomial based interpolation method. In (Johansson & Lowerborg, 2003), a frequency optimization technique is used a modified Farrow structure achieving a lower arithmetic complexity with different branch filters lengths. In (Yli-Kaakinen & Saramaki, 2006a, 2006a, 2007), multiplierless techniques were proposed for minimizing the number of arithmetic operations in the branch filters of the modified Farrow structure. A combination of a two-rate factor multirate structure and a time-domain designed FDF (Lagrange) was reported in (Murphy et al., 1994). The same approach is reported in (Hermanowicz, 2004), where symmetric Farrow structure branch filters are computed in time-domain with a symbolic approach. A combination of the two-rate factor multirate structure with a frequency-domain optimization process was firstly proposed in (Jovanovic-Docelek & Diaz-Carmona, 2002). In subsequence methods (Hermanowicz & Johansson, 2005) and (Johansson & Hermanowicz &, 2006), different optimization processes were applied to the same multirate structure. In (Hermanowicz & Johansson, 2005), a two stage FDF jointly optimized technique is applied. In (Johansson & Hermanowicz, 2006) a complexity reduction is achieved by using an approximately linear phase IIR filter instead of a linear phase FIR in the interpolation process.
Most of the recently reported FDF design methods are based on the modified Farrow structure as well as on the multirate Farrow structure. Such implementation structures are briefly described in the following.
The modified Farrow structure is obtained by approximating the reconstruction filter with the interpolation variable 2
for
for
The reconstruction filter
where
Basis polynomials for modified Farrow structure for 0≤
The modified Farrow structure has the following properties: 1) polynomial coefficients
The frequency design method in (Vesma et al., 1998) is based on the following properties of the branch digital filters
The FIR filter
In the modified Farrow structure, the FIR filters
Each filter
In same way, it is possible to approximate the input signal through Taylor series in a modified Farrow structure for each
Modified Farrow structure.
The input design parameters are: the filter length
The
where:
Hence the objective function is given as:
From this equation it can be observed that the design of a wide bandwidth FDF requires an extensive computing workload. For high fractional delay resolution FDF, high precise differentiator approximations are required; this imply high branch filters length,
A two-rate-factor structure in (Murphy et al., 1994), is proposed for designing FDF in time-domain. The input signal bandwidth is reduced by increasing to a double sampling frequency value. In this way Lagrange interpolation is used in the filter coefficients computing, resulting in a wideband FDF.
The multirate structure, shown in Fig. 14, is composed of three stages. The first one is an upsampler and a half-band image suppressor
The resulting implementation structure for
FDF Multirate structure.
Single-sampling-frequency structure.
Equivalent single-sampling-frequency structure.
The use of the obtained structure in combination with a frequency optimization method for computing the branch filters
The decrease in the optimization frequency range allows an abrupt reduction in the coefficient computation time for wideband FDF, and this less severe condition allows a resulting structure with smaller length of filters
The half-band
In (Ramirez-Conejo, 2010) and (Ramirez-Conejo et al., 2010a), the branch filters coefficients
where
The coefficients computing of the resulting FDF structure, shown in Fig. 16, is done through frequency optimization for global magnitude approximation to the ideal frequency response in a minimax sense. The objective function is defined as:
The objective function is minimized until a magnitude error specification
where
As is well known, the initial solution plays a key role in a minimax optimization process, (Johansson & Lowenborg, 2003), the proposed initial solution is the individual branch filters approximations to the
The initial half-band filter
The fact of using the proposed optimization process allows the design of a wideband FDF structure with small arithmetic complexity. Examples of such designing are presented in section 5.
An implementation of this FDF design method is reported in (Ramirez-Conejo et al., 2010b), where the resulting structure, as one shown in Fig. 16, is implemented in a reconfigurable hardware platform.
The results obtained with FDF design methods described in (Diaz-Carmona et al., 2010) and (Ramirez-Conejo et al., 2010) are shown through three design examples, that were implemented in MATLAB.
Example 1:
The design example is based on the method described in (Diaz-Carmona et al., 2010). The desired FDF bandwidth is 0.9
A half-band filter
The frequency optimization is applied up to only
The frequency responses of the resulted FDF from
The use of the optimization process (Vesma et al., 1998) with design parameters of
Frequency responses of the first seven ideal differentiators (dotted line) and the obtained approximations (solid line) in 0≤
First seven differentiator ideal frequency responses (dotted line) and obtained approximations (solid line) in 0≤
FDF frequency responses using half band frequency optimization method for
FDF frequency responses, using all-bandwidth frequency optimization method for
In order to compare the frequency-domain approximation achieved by the described method with existing design methods results, the frequency-domain absolute error
The maximum absolute magnitude error and the root mean square error obtained are shown in Table 1, reported in (Diaz-Carmona et al., 2010), as well as the results reported by some design methods.
(Tarczynski et al., 1997) | -100.0088 | 2.9107x10-6 |
(Wu-Sheng, & Tian-Bo, 1999) | -100.7215 | 2.7706x10-6 |
(Tian-Bo, 2001) | -99.9208 | 4.931x10-4 |
(Zhao & Yu, 2006) | -99.3669 | 2.8119x10-6 |
(Vesma et al., 1998) | -93.69 | 4.81x10-4 |
(Diaz-Carmona et al., 2010) | -86.17 | 2.78x10-4 |
Magnitude frequency response error comparison.
Example 2:
The FDF is designed using the explained minimax optimization approach applied on the single-sampling-frequency structure, Fig. 16, according to (Ramirez et al., 2010a). The FDF specifications are:
(Vesma & Saramaki, 1997) | 26 | 4 | 69 | 91 | 0.006571 | 0.0006571 |
(Johansson, & Lowenborg, 2003) | 28 | 5 | 57 | 72 | 0.005608 | 0.0005608 |
(Yli-Kaakinen & Saramaki, 2006a) | 28 | 4 | 32 | 56 | 0.009069 | 0.0009069 |
(Yli-Kaakinen & Saramaki, 2006b) | 28 | 4 | 31 | 50 | 0.009742 | 0.0009742 |
(Yli-Kaakinen & Saramaki, 2007) | 28 | 4 | 30 | - | 0.009501 | 0.0009501 |
(Ramirez-Conejo et al.,2010) | 7 | 4 | 32 | 47 | 0.0094448 | 0.0009664 |
Arithmetic complexity results for example 2.- Not reported
FDF frequency responses, using minimax optimization approach in example 2.
FDF frequency response errors, using minimax optimization approach in example 2.
Example 3:
This example shows that the same minimax optimization approach can be extended for approximating a global complex error. For this purpose, the filter design example described in (Johansson & Lowenborg 2003) is used, which specifications are
(Johansson & Lowenborg 2003) | 39 | 6 | 73 |
(Johansson & Lowenborg 2003)a | 31 | 5 | 50 |
(Hermanowicz, 2004) | 11 | 6 | 60(54) |
(Hermanowicz & Johansson, 2005) | 7 | 5 | 36 |
(Hermanowicz & Johansson, 2005)b | 7 | 3 | 26 |
(Johansson & Hermanowicz, 2006) | - | 6 | 32 |
(Johansson & Hermanowicz, 2006)b | - | 3 | 22 |
(Ramirez-Conejo et al., 2010) | 7 | 4 | 35 |
Arithmetic complexity results for example 3.a. Minimax design with subfilters jointly optimized.
FDF frequency complex error, using minimax optimization approach in example 3.
FDF frequency response using minimax optimization approach in example 3.
FDF frequency response errors using minimax optimization approach in example 3.
The concept of fractional delay filter is introduced, as well as a general description of most of the existing design methods for FIR fractional delay filters is presented. Accordingly to the explained concepts and to the results of recently reported design methods, one of the most challenging approaches for designing fractional delay filters is the use of frequency-domain optimization methods. The use of MATLAB as a design and simulation platform is a very useful tool to achieve a fractional delay filter that meets best the required frequency specifications dictated by a particular application.
Authors would like to thank to the Technological Institute of Celaya at Guanajuato State, Mexico for the facilities in the project development, and CONACYT for the support.
An anastomosis is a surgical connection between two structures. It usually means a connection that is created between tubular structures, such as blood vessels or loops of the intestine. Surgeons can choose to join together the two parts of the intestine by using either sewing (sutures) or staples. Sewing by hand has been used successfully for over 100 years. However, stapling takes less time to perform. As with any intervention, anastomosis carries some risks. These include blood clots, bleeding, scarring, blockage, stricture, or abnormal narrowing, damage to the surrounding structures, and infections, all of which can lead to anastomotic leakage, sepsis, septic shock, or even death (Figures 1 and 2).
Intraoperative aspect of an anastomosis performed manually at the level of the small bowel.
Intraoperative aspect of an anastomosis performed mechanically at the level of the small bowel.
Barbed sutures are available in a variety of both absorbable and nonabsorbable monofilament materials. Specifically, currently available bidirectional and unidirectional barbed suture materials include PDO, polyglyconate, poliglecaprone 25, glycomer 631, nylon, and polypropylene. A study performed by Wiggins [1] searched through a systematic review and meta-analysis for the benefits of barbed suture utilization in gastrointestinal anastomosis. The conclusion was that the use of barbed sutures for gastrointestinal anastomosis appears to be associated with shorter overall operative times. There was no difference in rates of complications (including anastomotic leak, bleeding, or stricture) compared with standard suture materials.
The study included consecutive CD patients with ileal/ileocolonic strictures who had SWE shear wave elastography within one week of surgical resection.
The SWE of the stenotic bowel wall was compared to the biofragmentable anastomosis ring used for gastrointestinal anastomoses in a literature review conducted by Bobkiewicz and coauthors [2].
The theoretical idea was that a biofragmentable anastomosis ring (BAR) could be used instead of manual and stapled anastomoses in the upper and lower GI tracts.
The aim of this study was to see how effective BAR was for bowel anastomoses using our own content. Methodologies: Between 2004 and 2014, a retrospective study was conducted on a total of 203 patients who underwent bowel surgery with BAR anastomosis in the upper and lower gastrointestinal tract. The study concluded that using BAR for GI tract anastomoses is an easy and quick procedure with a low rate of perioperative mortality (0.5%) and complication rates (Figures 3 and 4).
Foreign body reaction at the level of the tissues containing suture material.
Colorful surgical nylon monofilament suture with a curved needle.
The ideal stapling device should be capable of rapid creation of an anastomosis with serosal apposition without the persistence of a foreign body or a foreign body reaction, which potentially contributes to early anastomotic dehiscence or late anastomotic stricture (Figures 5 and 6).
Linear surgical stapler.
(a and b) circular stapling device and its mode of appliance.
While 2-row stapling has become normal in low anterior resections (LARs), it has no effect on morbidity or the incidence of AL.
Conducted by Nekliudov [3] is the first prospective, randomized clinical trial that compares the success rate of modern 3-row circular staplers to that of traditional 2-row staplers.
According to the hypothesis, the frequency of AL in the 3-row stapler group is not significantly higher than in the 2-row stapler group.
The rate of AL, as determined by imaging studies and measured using the Pearson chi-squared test and Fisher exact test, is the primary endpoint.
Secondary outcomes include AL severity (A, B, or C), anastomotic bleeding, postoperative complication rate (graded using the Clavien-Dindo classification), reintervention rate, stapler dysfunction rate, complications of nonfunctioning stoma, overall and cancer-specific quality of life (measured using short-form (36) questionnaire and quality-of-life (30) questionnaire core, respectively), fecal incontinence, and overall and cancer-specific quality of life.
Following the LAR, both patients will be tracked for a period of 12 months.
This is the first prospective randomized trial to look at the efficacy of 3-row staplers for colorectal anastomosis following rectal cancer surgery.
It could show that 3-row circular staplers are feasible in LAR in terms of short- and long-term patient outcomes (Figures 7 and 8).
2-row staple lines.
3-row staple lines.
A study performed by Jeong and coauthors [4] was assembled to report an institution’s experiences with transanal total mesorectal excision (TME) of rectal cancer using single-port equipment and to discuss the feasibility and safety of the technique. In the institution mentioned, 10 patients (6:4) treated with transanal TME with colorectal anastomosis were examined (Figure 9).
Complete TME specimen (a) and sectioned (b) after abdomino-perineal resection with intact mesorectum.
In six of 10 patients, TME was done without the use of a laparoscope.
The average time spent on the operating table was 303.5 minutes.
The distal margin was 2.1 (0.2–4.2) cm on average.
The average number of lymph nodes harvested is 17.5.
Except for one patient who had an anastomotic leak, the majority of patients began dietary intake on POD 3 and were discharged on POD 7.
The only postoperative complication was an anastomotic leak.
Conclusions: In selected cases of rectal cancer, pure natural orifice transluminal endoscopic surgery (NOTES) TME with coloanal anastomosis was found to be healthy and feasible.
Anastomotic leak (AL) is a common problem in colorectal surgery, and its prevalence has remained steady in recent years.
The use of an intra-abdominal drain or mechanical bowel preparation to prevent AL has been shown to be ineffective and should be avoided.
The function of oral antibiotic preparation regimens should be explained and compared to other routes of administration, such as intravenous or enema, according to a study conducted by Meyer and coauthors [5].
Parallel to this, preoperative antibiotherapy should target pathogens that induce collagenase, as defined by the microbiome study.
Fluorescence angiography may minimize AL even further, resulting in major intraoperative improvements in surgical strategies.
Fluorescence angiography can be used more often.
There have been studies, such as the one by Gained and coauthors [6], that looked at the literature’s connection between colorectal cancer recurrence, microbiome, and anastomotic leakage, and among the findings, one can find the aspect according to which the numerous mechanisms by which environmental factors act on the microbiome to alter its composition and function, with the net effect of adversely affecting oncological outcomes following surgery, are well documented and increasing.
Diet, antibiotic use, the procedures used to prepare the colon for surgery, and the physiological discomfort of the procedure are all examples of environmental causes.
Furthermore, using next-generation sequencing technologies to investigate the intestinal microbiome has the ability to affect cancer outcomes following colon resection. In a systematic review that targeted the endoscopic management of early postoperative complications, a literature search was performed by Clifford and coauthors [7] for published full text articles using the PubMed, Cochrane, and Scopus databases using the search criteria string “colorectal anastomotic (“leak” or “bleed”),” “endoscopy,” and “endoscopic management.” Endoscopic therapy in the management of stable patients with colorectal anastomotic leaks appears safe and is associated with the high rates of technical performance in selected patients, according to a review of 89 papers.
The most suitable method, patient selection, and considering the practical and long-term consequences of this approach remain challenging.
To fully assess the function of these novel strategies, further data from large prospective cohort studies are needed.
Shalaby and coauthors [8] conducted another systematic review on endoluminal vacuum-assisted therapy as a salvage treatment for rectal anastomotic leakage and found the following findings among 476 articles identified, 17 studies reporting on 276 patients:
The weighted mean success rate was 853% (95% confidence interval [CI]: 801–905), with a median time from the start of EVT to full healing of 47 (range 40–105) days.
The weighted mean rate of stoma reversal was 759% (646–872%) across the studies.
After EVT, twenty-five patients (91%) needed additional interventions.
Thirty-eight patients (138%) experienced complications as a result of the procedure.
The weighted mean complication rate was 111% (60–162%) across all tests.
Preoperative radiotherapy, the absence of a diverting stoma, complications, and male sex were all found to be significantly associated with failure.
According to the findings of the study, EVT is linked to a high rate of full healing of anastomotic leakage and stoma reversal.
In appropriately selected patients with anastomotic leakage, it is a viable choice.
Colorectal cancer surgery is thought to involve “high tie” and “low tie” of the inferior mesenteric artery (IMA).
However, the blood supply of the anastomosis is closely linked to the ligation stage, which can increase the leakage rate, and it is unclear which technique confers a lower anastomotic leakage rate (AL) and survival advantage.
The aim of the literature review, as stated by Yang and coauthors [9], was to compare the efficacy and impact of IMA high ligation versus IMA low ligation on anastomotic leakage, lymph node yield rates, and 5-year survival.
Finally, after reviewing studies from 1990 to 2017, researchers came to the conclusion that neither the high-tie nor the low-tie approach has any data in terms of anastomotic leakage, harvested lymph nodes, or 5-year survival rates.
More RCT is needed.
A study conducted by Simianu and coauthors [10] looked at the recency effect, which means that people place disproportionate emphasis on events that occurred recently when making decisions, but the magnitude of this influence on surgeons’ decisions is uncertain.
The use of preventative leak testing before and after colorectal operations with anastomotic leaks is examined in this study to see whether there is a recency effect in surgeons.
A prospective cohort of adult patients (aged 18 years) undergoing elective colorectal surgery at Washington State hospitals participating in the Surgical Care and Outcomes Assessment Program was used to develop the materials and methods (2006–2013).
The key outcome measure was the difference in leak monitoring between 6 months before and 6 months after an anastomotic leak.
A leak rate of 2.6% (n = 124) was found in 4854 elective colorectal operations performed by 282 surgeons at 44 hospitals.
The anastomosis was not checked in 40 leaks (32%), which were spread through 25 surgeons.
While the small sample size restricted the ability to detect an overall difference in leak testing use, 9 (36%) of the 25 surgeons increased their leak testing by 5% or more after leaks in cases where the anastomosis was not checked.
The above facts led to the conclusion that only one-third of qualified surgeons demonstrated the recency effect.