Source:
World Mine Production and Reserves (2009)
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"intechopen-supports-asapbio-s-new-initiative-publish-your-reviews-20220729",title:"IntechOpen Supports ASAPbio’s New Initiative Publish Your Reviews"},{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"}]},book:{item:{type:"book",id:"6989",leadTitle:null,fullTitle:"Biogenic Amines in Neurotransmission and Human Disease",title:"Biogenic Amines in Neurotransmission and Human Disease",subtitle:null,reviewType:"peer-reviewed",abstract:"Drawing on the expertise of experienced researchers in neurotransmission and catecholamines, this book provides a brief overview of the latest knowledge in the field. The book contains an introductory chapter that aims to explain the subsequent four chapters for researchers who are new to the field.",isbn:"978-1-83962-864-1",printIsbn:"978-1-83962-863-4",pdfIsbn:"978-1-83962-865-8",doi:"10.5772/intechopen.73738",price:100,priceEur:109,priceUsd:129,slug:"biogenic-amines-in-neurotransmission-and-human-disease",numberOfPages:90,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"4c7e866a847bc30d77f37feccdf72dbf",bookSignature:"Ahmet Uçar",publishedDate:"November 13th 2019",coverURL:"https://cdn.intechopen.com/books/images_new/6989.jpg",numberOfDownloads:3932,numberOfWosCitations:2,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:3,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:5,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 12th 2018",dateEndSecondStepPublish:"January 15th 2019",dateEndThirdStepPublish:"March 16th 2019",dateEndFourthStepPublish:"May 21st 2019",dateEndFifthStepPublish:"July 20th 2019",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"205106",title:"Associate Prof.",name:"Ahmet",middleName:null,surname:"Uçar",slug:"ahmet-ucar",fullName:"Ahmet Uçar",profilePictureURL:"https://mts.intechopen.com/storage/users/205106/images/system/205106.jpg",biography:"Prior to working at a major University of Health Sciences, Associate Prof. Ahmet Uçar received his degrees in pediatrics and then in pediatric Endocrinology with high honors at national exams. He has been actively working in the field of pediatric endocrinology and diabetes, and he has contributed to define the characteristics of pubertal variants, growth disorders, endocrine disorders in chronic diseases, pediatric diabetes and Turner Syndrome. Dr. Uçar has documented interest in almost all aspects of pediatric endocrinology and diabetes. He is a member of the Endocrine Society, European Society of Pediatric Endocrinology and Turkish Society of Pediatric Endocrinology. He actively participates in social activities involving refugee children and orphans at weekends.",institutionString:"University of Health Sciences",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"1",institution:{name:"Şişli Etfal Eğitim ve Araştırma Hastanesi",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"212",title:"Molecular Neuroscience",slug:"molecular-neuroscience"}],chapters:[{id:"68991",title:"Introductory Chapter: Biogenic Amines in Neurotransmission and Human Disease from the Endocrinologist’s Perspective",doi:"10.5772/intechopen.89244",slug:"introductory-chapter-biogenic-amines-in-neurotransmission-and-human-disease-from-the-endocrinologist",totalDownloads:757,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:null,signatures:"Ahmet Uçar",downloadPdfUrl:"/chapter/pdf-download/68991",previewPdfUrl:"/chapter/pdf-preview/68991",authors:[{id:"205106",title:"Associate Prof.",name:"Ahmet",surname:"Uçar",slug:"ahmet-ucar",fullName:"Ahmet Uçar"}],corrections:null},{id:"68056",title:"Kainate Receptors Modulating Glutamate Release in the Cerebellum",doi:"10.5772/intechopen.87984",slug:"kainate-receptors-modulating-glutamate-release-in-the-cerebellum",totalDownloads:855,totalCrossrefCites:0,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Glutamate receptors of the kainate type (Kainate receptors, KARs), are mediators of ionotropic postsynaptic synaptic transmission, as well as presynaptic modulators of neurotransmitter release where they show both ionotropic and metabotropic actions regulating glutamate and γ-aminobutiric acid (GABA) release. The mechanisms underlying these modulatory roles are starting to be understood at some brain regions. Here we review the KARs roles and mechanisms involved in the modulation of glutamate release in the cerebellum at parallel fibers (PF)-Purkinje Cells (PuC) synapses. KARs activation mediate a biphasic effect on glutamate release at this synapse, with low kainate (KA) concentrations mediating a facilitation of glutamate release and higher KA concentrations mediating a depression of glutamate release. KA-mediated facilitation is prevented by antagonizing KARs, by inhibition of PKA or stimulation of adenylyl cyclase (AC), by blocking Ca2+ permeant KARs, by depleting intracellular Ca2+ stores and by blocking calmodulin. Thus, at cerebellar parallel fiber-Purkinje cell synapses, presynaptic KARs mediate glutamate release facilitation through Ca2+-calmodulin dependent activation of adenylyl cyclase/cAMP/protein kinase A signaling. KAR-mediated depression of glutamate release involves the AC/cAMP/PKA pathway as for facilitation but not Ca2+-calmodulin, being in this case AC activated by a Gi/o protein to mediate a depression of glutamate release.",signatures:"Pilar Losada-Ruiz, Rafael Falcón-Moya and Antonio Rodríguez-Moreno",downloadPdfUrl:"/chapter/pdf-download/68056",previewPdfUrl:"/chapter/pdf-preview/68056",authors:[{id:"94819",title:"Dr.",name:"Antonio",surname:"Rodríguez-Moreno",slug:"antonio-rodriguez-moreno",fullName:"Antonio Rodríguez-Moreno"},{id:"305279",title:"Ms.",name:"Pilar",surname:"Losada-Ruiz",slug:"pilar-losada-ruiz",fullName:"Pilar Losada-Ruiz"},{id:"305280",title:"Mr.",name:"Rafael",surname:"Falcón.Moya",slug:"rafael-falcon.moya",fullName:"Rafael Falcón.Moya"}],corrections:null},{id:"67286",title:"Homeostatic Plasticity and Therapeutic Approaches in Neurodegeneration",doi:"10.5772/intechopen.86415",slug:"homeostatic-plasticity-and-therapeutic-approaches-in-neurodegeneration",totalDownloads:905,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The synapses transmit signals between neurons in an ever-changing fashion. Changes of synaptic transmission arise from numerous mechanisms known as synaptic plasticity. The importance and complexity of the synapse has fueled research into the molecular mechanisms underlying synaptogenesis, synaptic transmission, and plasticity. Particularly, homeostatic plasticity refers to the local changes in synaptic activation to generate local synaptic adaptations and network-wide changes in activity to generate adjustments between excitation and inhibition. This review chapter will focus on synaptic phenomena and mechanisms that are likely to contribute to network homeostasis. In addition, it will be discussed a putative modulation of the signaling mechanisms serving a homeostatic function as a viable therapeutic approach for disease modification in neurological and neurodegenerative disorders. To sum up, the main role of the following players in homeostatic plasticity will be analyzed, based on what a growing body of evidence has suggested recently: BDNF-mediated TrkB system activation; adenosine modulation system; nitric oxide/soluble GC/cGMP signaling; astrocyte involvement—astroglial CB1 receptors; the microtubule-associated neuronal protein Tau; the signaling pathway of the Wnt protein family; extracellular vesicles in the intercellular communication; and estrogen involvement in non-reproductive functions.",signatures:"Sagrario Martin-Aragon, Paloma Bermejo-Bescós, Pilar González and Juana Benedí",downloadPdfUrl:"/chapter/pdf-download/67286",previewPdfUrl:"/chapter/pdf-preview/67286",authors:[{id:"294917",title:"Prof.",name:"Sagrario",surname:"Martin-Aragon",slug:"sagrario-martin-aragon",fullName:"Sagrario Martin-Aragon"},{id:"299459",title:"Prof.",name:"Paloma",surname:"Bermejo-Bescós",slug:"paloma-bermejo-bescos",fullName:"Paloma Bermejo-Bescós"},{id:"299461",title:"Dr.",name:"Pilar",surname:"González",slug:"pilar-gonzalez",fullName:"Pilar González"},{id:"299462",title:"Prof.",name:"Juana",surname:"Benedí",slug:"juana-benedi",fullName:"Juana Benedí"}],corrections:null},{id:"67206",title:"The Pharmacological Effects of Herbs on Catecholamine Signaling",doi:"10.5772/intechopen.81510",slug:"the-pharmacological-effects-of-herbs-on-catecholamine-signaling",totalDownloads:695,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Herbs have many biologically and pharmacologically active compounds such as flavonoids and stilbenes. They have been used in remedies for various disorders. Here we review the effects of herbs on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells. Ikarisoside A (1.0–100 μM), a flavonol glycoside, inhibited the catecholamine secretion induced by acetylcholine (0.3 mM). This inhibition was associated with the suppression of 22Na+ and 45Ca2+ influx induced by acetylcholine. The ethanol extract (0.0003–0.005%) of matsufushi (extract of pine nodules) inhibited the catecholamine secretion induced by acetylcholine. SJ-2, one of the stilbene compounds isolated from matsufushi, inhibited acetylcholine-induced catecholamine secretion. Matsufushi extract and SJ-2 reversibly inhibited acetylcholine-induced Na+ currents in Xenopus oocytes expressed with α3β4nicotinic acetylcholine receptors. Sweet tea is the processed leaves of Hydrangea macrophylla. The extract of sweet tea (0.3–1.0 mg/ml) suppressed catecholamine secretion induced by acetylcholine (0.3 mM). Moreover, sweet tea (0.1–1.0 mg/ml), ikarisoside A (1.0–100 μM), and matsufushi (0.001–0.003%) or SJ-2 (10–30 μM) inhibited acetylcholine-induced 14C-catecholamine synthesis from 14C-tyrosine. These findings indicate that ikarisoside A, matsufushi (or SJ-2), and sweet tea inhibit the catecholamine secretion and synthesis induced by acetylcholine in cultured bovine adrenal medullary cells and probably in sympathetic neurons.",signatures:"Nobuyuki Yanagihara, Xiaoja Li, Yumiko Toyohira, Noriaki Satoh, Hui Shao, Yasuhiro Nozaki, Shin Ishikane, Fumi Takahashi, Ryo Okada, Hideyuki Kobayashi, Masato Tsutsui and Taizo Kita",downloadPdfUrl:"/chapter/pdf-download/67206",previewPdfUrl:"/chapter/pdf-preview/67206",authors:[{id:"37854",title:"Dr.",name:"Yumiko",surname:"Toyohira",slug:"yumiko-toyohira",fullName:"Yumiko Toyohira"},{id:"37857",title:"Prof.",name:"Masato",surname:"Tsutsui",slug:"masato-tsutsui",fullName:"Masato Tsutsui"},{id:"266081",title:"Prof.",name:"Nobuyuki",surname:"Yanagihara",slug:"nobuyuki-yanagihara",fullName:"Nobuyuki Yanagihara"},{id:"272066",title:"Dr.",name:"Xiaoja",surname:"Li",slug:"xiaoja-li",fullName:"Xiaoja Li"},{id:"272067",title:"Dr.",name:"Noriaki",surname:"Satoh",slug:"noriaki-satoh",fullName:"Noriaki Satoh"},{id:"272068",title:"Dr.",name:"Hui",surname:"Shao",slug:"hui-shao",fullName:"Hui Shao"},{id:"272069",title:"BSc.",name:"Yasuhiro",surname:"Nozaki",slug:"yasuhiro-nozaki",fullName:"Yasuhiro Nozaki"},{id:"272070",title:"Prof.",name:"Fumi",surname:"Takahashi",slug:"fumi-takahashi",fullName:"Fumi Takahashi"},{id:"272071",title:"Dr.",name:"Ryo",surname:"Okada",slug:"ryo-okada",fullName:"Ryo Okada"},{id:"272072",title:"Prof.",name:"Hideyuki",surname:"Kobayashi",slug:"hideyuki-kobayashi",fullName:"Hideyuki Kobayashi"},{id:"272074",title:"Prof.",name:"Taizo",surname:"Kita",slug:"taizo-kita",fullName:"Taizo Kita"}],corrections:null},{id:"68232",title:"Thrombotic Tendencies in Excess Catecholamine States",doi:"10.5772/intechopen.81929",slug:"thrombotic-tendencies-in-excess-catecholamine-states",totalDownloads:720,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"Catecholamines are neurotransmitters distributed throughout the body including adrenal glands, chromaffin tissues and other tissues innervated by post ganglionic adrenergic neurons. The rate of release of medullary hormones is responsible for the control of serum catecholamines. Thrombogenicity of catecholamines are due various mechanisms including hypercoagulable states, endothelial damage, blood stasis and platelet aggregation. Oxidative stress generated by catecholamine excess causes coronary spasm, ultrastructural cell damage and arrhythmias. Elevated plasminogen activator inhibitor-1 during catecholamine excess causes hypercoagulability by hypofibrinosis. During stress, Catecholamines released in procoagulant environment causes vasoconstriction in adrenal veins resulting in venous thrombosis. Catecholamines generate moderately elevated levels of platelet count which enhances the risk of thrombosis. Hypercoagulability results in formation of coronary thrombus, rupture of atherosclerotic plaque and plaque progression due to gradual fibrinogen accumulation in the vessel walls. High levels of circulating catecholamines produce elevated levels thrombomodulin, the biomarkers of endothelial cell damage. In patients with hypertension in catecholamine excess, resistance to blood flow and damage to the integrity of blood vessels lead to atherosclerosis. A case report has been discussed which suggests an association of thrombotic tendency and catecholamine excess.",signatures:"Vivek K. Nambiar and Drisya Rajan Chalappurath",downloadPdfUrl:"/chapter/pdf-download/68232",previewPdfUrl:"/chapter/pdf-preview/68232",authors:[{id:"264830",title:"Dr.",name:"Vivek",surname:"Nambiar",slug:"vivek-nambiar",fullName:"Vivek Nambiar"},{id:"279837",title:"Ms.",name:"Drisya",surname:"Rajan",slug:"drisya-rajan",fullName:"Drisya Rajan"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"6237",title:"GABA And Glutamate",subtitle:"New Developments In Neurotransmission Research",isOpenForSubmission:!1,hash:"9883dc7bb642e8ae919261b2519547ba",slug:"gaba-and-glutamate-new-developments-in-neurotransmission-research",bookSignature:"Janko Samardzic",coverURL:"https://cdn.intechopen.com/books/images_new/6237.jpg",editedByType:"Edited by",editors:[{id:"188756",title:"Dr.",name:"Janko",surname:"Samardzic",slug:"janko-samardzic",fullName:"Janko Samardzic"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"6998",title:"Synucleins",subtitle:"Biochemistry and Role in Diseases",isOpenForSubmission:!1,hash:"2b4b802fec508928ce8ab9deebd1375f",slug:"synucleins-biochemistry-and-role-in-diseases",bookSignature:"Andrei Surguchov",coverURL:"https://cdn.intechopen.com/books/images_new/6998.jpg",editedByType:"Edited by",editors:[{id:"266540",title:"Dr.",name:"Andrei",surname:"Surguchov",slug:"andrei-surguchov",fullName:"Andrei Surguchov"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"10195",title:"Serotonin and the CNS",subtitle:"New Developments in Pharmacology and Therapeutics",isOpenForSubmission:!1,hash:"7ed9d96da98233a885bd2869a8056c36",slug:"serotonin-and-the-cns-new-developments-in-pharmacology-and-therapeutics",bookSignature:"Berend Olivier",coverURL:"https://cdn.intechopen.com/books/images_new/10195.jpg",editedByType:"Edited by",editors:[{id:"71579",title:"Prof.",name:"Berend",surname:"Olivier",slug:"berend-olivier",fullName:"Berend Olivier"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"1591",title:"Infrared Spectroscopy",subtitle:"Materials Science, Engineering and Technology",isOpenForSubmission:!1,hash:"99b4b7b71a8caeb693ed762b40b017f4",slug:"infrared-spectroscopy-materials-science-engineering-and-technology",bookSignature:"Theophile Theophanides",coverURL:"https://cdn.intechopen.com/books/images_new/1591.jpg",editedByType:"Edited by",editors:[{id:"37194",title:"Dr.",name:"Theophile",surname:"Theophanides",slug:"theophile-theophanides",fullName:"Theophile Theophanides"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3161",title:"Frontiers in Guided Wave Optics and Optoelectronics",subtitle:null,isOpenForSubmission:!1,hash:"deb44e9c99f82bbce1083abea743146c",slug:"frontiers-in-guided-wave-optics-and-optoelectronics",bookSignature:"Bishnu Pal",coverURL:"https://cdn.intechopen.com/books/images_new/3161.jpg",editedByType:"Edited by",editors:[{id:"4782",title:"Prof.",name:"Bishnu",surname:"Pal",slug:"bishnu-pal",fullName:"Bishnu Pal"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"371",title:"Abiotic Stress in Plants",subtitle:"Mechanisms and Adaptations",isOpenForSubmission:!1,hash:"588466f487e307619849d72389178a74",slug:"abiotic-stress-in-plants-mechanisms-and-adaptations",bookSignature:"Arun Shanker and B. Venkateswarlu",coverURL:"https://cdn.intechopen.com/books/images_new/371.jpg",editedByType:"Edited by",editors:[{id:"58592",title:"Dr.",name:"Arun",surname:"Shanker",slug:"arun-shanker",fullName:"Arun Shanker"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"3092",title:"Anopheles mosquitoes",subtitle:"New insights into malaria vectors",isOpenForSubmission:!1,hash:"c9e622485316d5e296288bf24d2b0d64",slug:"anopheles-mosquitoes-new-insights-into-malaria-vectors",bookSignature:"Sylvie Manguin",coverURL:"https://cdn.intechopen.com/books/images_new/3092.jpg",editedByType:"Edited by",editors:[{id:"50017",title:"Prof.",name:"Sylvie",surname:"Manguin",slug:"sylvie-manguin",fullName:"Sylvie Manguin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"72",title:"Ionic Liquids",subtitle:"Theory, Properties, New Approaches",isOpenForSubmission:!1,hash:"d94ffa3cfa10505e3b1d676d46fcd3f5",slug:"ionic-liquids-theory-properties-new-approaches",bookSignature:"Alexander Kokorin",coverURL:"https://cdn.intechopen.com/books/images_new/72.jpg",editedByType:"Edited by",editors:[{id:"19816",title:"Prof.",name:"Alexander",surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"2270",title:"Fourier Transform",subtitle:"Materials Analysis",isOpenForSubmission:!1,hash:"5e094b066da527193e878e160b4772af",slug:"fourier-transform-materials-analysis",bookSignature:"Salih Mohammed Salih",coverURL:"https://cdn.intechopen.com/books/images_new/2270.jpg",editedByType:"Edited by",editors:[{id:"111691",title:"Dr.Ing.",name:"Salih",surname:"Salih",slug:"salih-salih",fullName:"Salih Salih"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"117",title:"Artificial Neural Networks",subtitle:"Methodological Advances and Biomedical Applications",isOpenForSubmission:!1,hash:null,slug:"artificial-neural-networks-methodological-advances-and-biomedical-applications",bookSignature:"Kenji Suzuki",coverURL:"https://cdn.intechopen.com/books/images_new/117.jpg",editedByType:"Edited by",editors:[{id:"3095",title:"Prof.",name:"Kenji",surname:"Suzuki",slug:"kenji-suzuki",fullName:"Kenji Suzuki"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}],ofsBooks:[]},correction:{item:{id:"79356",slug:"corrigendum-to-goat-a-sustainable-and-holistic-approach-in-addressing-triple-challenges-of-gender-in",title:"Corrigendum to: Goat - A Sustainable and Holistic Approach in Addressing Triple Challenges of Gender Inequality, Climate Change Effects, Food and Nutrition Insecurity in Rural Communities of Sub-Saharan Africa",doi:null,correctionPDFUrl:"https://cdn.intechopen.com/pdfs/81455.pdf",downloadPdfUrl:"/chapter/pdf-download/81455",previewPdfUrl:"/chapter/pdf-preview/81455",totalDownloads:null,totalCrossrefCites:null,bibtexUrl:"/chapter/bibtex/81455",risUrl:"/chapter/ris/81455",chapter:{id:"75448",slug:"goat-a-sustainable-and-holistic-approach-in-addressing-triple-challenges-of-gender-inequality-climat",signatures:"Never Assan",dateSubmitted:"November 24th 2020",dateReviewed:"February 4th 2021",datePrePublished:"February 26th 2021",datePublished:null,book:{id:"9706",title:"Goat Science - Environment, Health and Economy",subtitle:null,fullTitle:"Goat Science - Environment, Health and Economy",slug:null,publishedDate:null,bookSignature:"Dr. Sándor Kukovics",coverURL:"https://cdn.intechopen.com/books/images_new/9706.jpg",licenceType:"CC BY 3.0",editedByType:null,editors:[{id:"25894",title:"Dr.",name:"Sándor",middleName:null,surname:"Kukovics",slug:"sandor-kukovics",fullName:"Sándor Kukovics"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null}},chapter:{id:"75448",slug:"goat-a-sustainable-and-holistic-approach-in-addressing-triple-challenges-of-gender-inequality-climat",signatures:"Never Assan",dateSubmitted:"November 24th 2020",dateReviewed:"February 4th 2021",datePrePublished:"February 26th 2021",datePublished:null,book:{id:"9706",title:"Goat Science - Environment, Health and Economy",subtitle:null,fullTitle:"Goat Science - Environment, Health and Economy",slug:null,publishedDate:null,bookSignature:"Dr. Sándor Kukovics",coverURL:"https://cdn.intechopen.com/books/images_new/9706.jpg",licenceType:"CC BY 3.0",editedByType:null,editors:[{id:"25894",title:"Dr.",name:"Sándor",middleName:null,surname:"Kukovics",slug:"sandor-kukovics",fullName:"Sándor Kukovics"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null},book:{id:"9706",title:"Goat Science - Environment, Health and Economy",subtitle:null,fullTitle:"Goat Science - Environment, Health and Economy",slug:null,publishedDate:null,bookSignature:"Dr. Sándor Kukovics",coverURL:"https://cdn.intechopen.com/books/images_new/9706.jpg",licenceType:"CC BY 3.0",editedByType:null,editors:[{id:"25894",title:"Dr.",name:"Sándor",middleName:null,surname:"Kukovics",slug:"sandor-kukovics",fullName:"Sándor Kukovics"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}}},ofsBook:{item:{type:"book",id:"11725",leadTitle:null,title:"The Erythrocyte - A Unique Cell",subtitle:null,reviewType:"peer-reviewed",abstract:"\r\n\tThe Erythrocyte is unique and forms a model for studying various situations/ physiological conditions.
\r\n\tThis cell has evolved an effective defense system to counteract the challenges as it is always in an oxygen-rich environment. The evolution of hemoglobin and deformability of erythrocyte membrane adapting to its function in circulation is especially striking. Erythrocyte aging and eryptosis strike a balance - the mixed population of cells and constant recycling every 120 days is a very distinct feature. Its metabolic shunt pathways and metabolites/enzymes alter and adapt with age and changes in the microenvironment.
\r\n\tErythrocyte and its cytoskeleton responses to various situations such as infections, hypoxia, hypothermia, intrigues researchers and biologists alike. This book aims to throw light on the significance of erythrocyte and its characteristic nature and survival in different physiological situations as it plays a very crucial role.
\r\n\r\n\tThis book hopes to bring different perspectives from various aspects and provide insights into the effective mechanisms evolved by erythrocytes, to counteract the challenges faced in its oxidation environment and the further research approaches.
",isbn:"978-1-80356-732-7",printIsbn:"978-1-80356-731-0",pdfIsbn:"978-1-80356-733-4",doi:null,price:0,priceEur:0,priceUsd:0,slug:null,numberOfPages:0,isOpenForSubmission:!1,isSalesforceBook:!1,isNomenclature:!1,hash:"1b6073b9ff3f8f63004943bd263cd04e",bookSignature:"Dr. Vani Rajashekaraiah",publishedDate:null,coverURL:"https://cdn.intechopen.com/books/images_new/11725.jpg",keywords:"Erythrocyte, Hemoglobin, Erythrocyte Aging, Pathways, Metabolites, Deficiencies, Membrane Changes, Band 3, Deformability, Hemolysis, Disease Conditions, Free Radical Initiators",numberOfDownloads:null,numberOfWosCitations:0,numberOfCrossrefCitations:null,numberOfDimensionsCitations:null,numberOfTotalCitations:null,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"March 24th 2022",dateEndSecondStepPublish:"May 26th 2022",dateEndThirdStepPublish:"July 25th 2022",dateEndFourthStepPublish:"October 13th 2022",dateEndFifthStepPublish:"December 12th 2022",dateConfirmationOfParticipation:null,remainingDaysToSecondStep:"3 months",secondStepPassed:!0,areRegistrationsClosed:!0,currentStepOfPublishingProcess:4,editedByType:null,kuFlag:!1,biosketch:"Dr. Vani Rajashekaraiah, Associate Professor, JAIN (Deemed-to-be University), Bangalore has 20 years of research experience in Oxidative Stress Physiology and Hematology and 16 years of teaching experience. She has authored numerous journal papers and book chapters and has one published patent. She has received CSIR research fellowship and is a Member of the Society for Free Radical Research, India.",coeditorOneBiosketch:null,coeditorTwoBiosketch:null,coeditorThreeBiosketch:null,coeditorFourBiosketch:null,coeditorFiveBiosketch:null,editors:[{id:"352876",title:"Dr.",name:"Vani",middleName:null,surname:"Rajashekaraiah",slug:"vani-rajashekaraiah",fullName:"Vani Rajashekaraiah",profilePictureURL:"https://mts.intechopen.com/storage/users/352876/images/system/352876.jpg",biography:"Teaching Experience: 16 years\n•\tAssociate Professor in Biotechnology, School of Sciences, Block I, JAIN (Deemed-to-be University), Bengaluru from May 2018 till date. (Courses: Molecular Genetics, Molecular Biology and Genetic Engineering). \n Research Experience: 20 years in the field of Oxidative Stress Physiology and hematology.\n Current Research focus: Blood Storage (erythrocytes, platelets) and Drug-induced Thrombocytopenia\n Total publications in SCOPUS / Web of Science: 27 and International book chapters: 04.\n Research guidance: 3 PhD students (completed); 3 PhD students guiding currently.\n \t \n Six years of research experience as JRF (CSIR) and SRF (CSIR) in the field of High Altitude Physiology and Biochemistry, specialization in Oxidative Stress Physiology, from August 2002 to 2008. \no\tPursued research under the guidance of Dr. S. Asha Devi, Professor, Dept. of \n Zoology, Bangalore University, Bangalore-560056, towards Ph.D in Zoology.\n Title of the thesis- “Studies on Oxidative Stress in Erythrocytes of Rats Exposed to \n Intermittent Hypobaric Hypoxia”.",institutionString:"Jain University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"Jain University",institutionURL:null,country:{name:"India"}}}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"16",title:"Medicine",slug:"medicine"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"185543",firstName:"Maja",lastName:"Bozicevic",middleName:null,title:"Mrs.",imageUrl:"https://mts.intechopen.com/storage/users/185543/images/4748_n.jpeg",email:"maja.b@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact."}},relatedBooks:[{type:"book",id:"6550",title:"Cohort Studies in Health Sciences",subtitle:null,isOpenForSubmission:!1,hash:"01df5aba4fff1a84b37a2fdafa809660",slug:"cohort-studies-in-health-sciences",bookSignature:"R. Mauricio Barría",coverURL:"https://cdn.intechopen.com/books/images_new/6550.jpg",editedByType:"Edited by",editors:[{id:"88861",title:"Dr.",name:"R. Mauricio",surname:"Barría",slug:"r.-mauricio-barria",fullName:"R. 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Recycling is not an “outside-of-the-box” approach but rather an “inside-of-the-box” method that has long been considered but was overtaken by the notion that resources are infinite. With societies’ hunger for raw materials to feed into their industrial demands, production of new materials has become challenging and economically inefficient. In the automobile industry, the demand for rare earth metals is exponentially growing with increasing demand for vehicles. China, which is a top source of rare earth metals, has imposed limits on the export of such product due to increasing internal demand. Japan, which sources metals from China, has had to make innovative steps to address the problem through “urban mining.” It refers to the recovery of rare earth metals from end-of-life (ELV) vehicles and electronic waste or e-waste(Saito & Yu, 2011). It does not require new materials to be extracted and it helps close the loop of sustainable resource circulation.
\n\t\t\tThe concept of urban mining came to fruition with the advent of recycling technologies. Japan, which is a leader in the automobile industry, has devised ways to recover and recycle used metal parts from ELVs. With the large volume of new vehicles produced each year, it was imperative to reduce the volume of waste from old vehicles thrown into incineration plants and landfills. Used car parts are deemed valuable to be discarded in the midst of competing demand for rare earth metals all over the world. The way to move forward with a booming automobile industry is to incorporate environmental responsibility through recycling. The benefits cannot be overemphasized from the point of a resource-deficient Japan. It is also paving the way for economic and social opportunities in the recycling sector. However, challenges abound in terms of supply and how urban mining could be sustainably done in developing countries where technologies are lacking. Likewise, exposure to toxic metals is high due to the manual nature of recovering used car parts.
\n\t\t\tRecovery and recycling per se are good but accompanying issues need to be addressed in developing countries so that real societal benefits are achieved. It is necessary that countries like Japan, Korea and China identify emerging lessons from the implementation of their respective ELV recycling laws so that developing countries can learn from them and craft laws that are appropriate and tailored to local needs and existing resources. This paper discusses the experiences of Japan and China in the field of urban mining and concomitant issues and challenges and how they will shape ELV recycling policies in East Asia. Outlook for the future will also be tackled as a way to create a road map for East Asia in the field of automobile recycling.
\n\t\tThe term “urban mining” was coined by Professor Nanjyo of Tohoku University in the 1980s to encourage and promote the reuse of precious and rare-earth metals found in used and discarded electronics. Japan, a heavy user of rare earth metals for its electronic and automobile industries, depends largely from China which produces 90% of the world’s rare earth metals. The table below shows the top producers of rare earth based on 2009 data:
\n\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t
United States | \n\t\t\t\t\t\tinsignificant | \n\t\t\t\t\t\t13,000,000 | \n\t\t\t\t\t
Australia | \n\t\t\t\t\t\tinsignificant | \n\t\t\t\t\t\t5,400,000 | \n\t\t\t\t\t
Brazil | \n\t\t\t\t\t\t650 | \n\t\t\t\t\t\t48,000 | \n\t\t\t\t\t
China | \n\t\t\t\t\t\t120,000 | \n\t\t\t\t\t\t36,000,000 | \n\t\t\t\t\t
Commonwealth of Independent States | \n\t\t\t\t\t\tNot available | \n\t\t\t\t\t\t19,000,000 | \n\t\t\t\t\t
India | \n\t\t\t\t\t\t2,700 | \n\t\t\t\t\t\t3,100,000 | \n\t\t\t\t\t
Malaysia | \n\t\t\t\t\t\t380 | \n\t\t\t\t\t\t30,000 | \n\t\t\t\t\t
Other countries | \n\t\t\t\t\t\tNot available | \n\t\t\t\t\t\t22,000,000 | \n\t\t\t\t\t
World total (rounded) | \n\t\t\t\t\t\t124,000 | \n\t\t\t\t\t\t99,000,000 | \n\t\t\t\t\t
Source:
World Mine Production and Reserves (2009)
In July 2010, China announced a 72% reduction of exports due to increasing domestic consumption. This prompted the Japanese government to search for alternative sources and a research made by the National Institute of Material Science, a research organization affiliated with the Japanese government, announced that 6,800 tons of gold can be recovered from used electronics in Japan. This massive reserve is projected to be equivalent of 16% of the world’s total reserves. Other reserves that can be generated are silver with 22%, tin with 11% and other materials at 5% (Kawakami, 2010). Clearly, the study showed the vast potential of internally sourcing rare earth metals in Japan rather than depending solely from foreign markets. It is sitting on mountains of used appliances and ELVs on its backyard where necessary resource inputs for new cars abound.
\n\t\t\tIn ELVs, various metals can be found from different parts of a car. The following figure shows the distribution of rare earth metalsfrom the exterior components of a car:
\n\t\t\tSource:
Rare earth metals in auto parts
It will be noted from the above figure that Chromium has the highest concentration in engines and processing equipment while Manganese is abundant in suspension and steering parts. The rest of rare earth metals are spread in other auto parts. In terms of the price of earth metals, the following table shows the resource market fluctuation for iron ore, iron scrap, copper, silver and gold:
\n\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t
Iron ore | \n\t\t\t\t\t\t135 | \n\t\t\t\t\t\t189.5 | \n\t\t\t\t\t\t40.37 | \n\t\t\t\t\t
Iron scrap | \n\t\t\t\t\t\t313.5 | \n\t\t\t\t\t\t462.5 | \n\t\t\t\t\t\t47.53 | \n\t\t\t\t\t
Copper | \n\t\t\t\t\t\t7,065 | \n\t\t\t\t\t\t9,585 | \n\t\t\t\t\t\t35.67 | \n\t\t\t\t\t
Gold | \n\t\t\t\t\t\t1,084.80 | \n\t\t\t\t\t\t1,340.70 | \n\t\t\t\t\t\t23.59 | \n\t\t\t\t\t
Silver | \n\t\t\t\t\t\t1,621.20 | \n\t\t\t\t\t\t2,791.90 | \n\t\t\t\t\t\t72.21 | \n\t\t\t\t\t
Source: Asahi Newspaper, 2011
Resource market fluctuation
The prices of valuable earth metals in the world market have significantly risen from 2010 to 2011 with silver achieving the highest increase. In terms of recycling market, the top three countries which have captured substantial markets for recycling are China, India and Japan as shown on the following:
\n\t\t\tSource: Ministry of Environment, Japan
Recycling markets in Asia
The momentum towards ELV recycling was jumpstarted by the European Union (EU) with the passage of an ELV recycling law in 2000. Japan passed the “Law for the Recycling of End-of-Life Vehicles” in 2005. Korea legislated the “Act for Resource Recycling of Electrical and Electronic Equipment and Vehicles“ in 2008. China, on the other hand, has “Statute 307” which was enforced in 2010. One of the salient features of this law is that vehicle producers of imported vehicles shall be responsible for the recovery and treatment of used vehicles (Serrona, Yu &Che, 2010). There are distinct variations in each of these laws but they all fall under the principle of “Extended Producer Responsibility” or EPR. Producers are largely responsible for recovery but consumers are also entrusted with certain responsibilities. It may be worth to comparatively revisit these laws as follows:
\n\t\t\t\n\t\t\t\t\t\t | \n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t
Implementation year | \n\t\t\t\t\t\t2000 | \n\t\t\t\t\t\t2005 | \n\t\t\t\t\t\t2008 | \n\t\t\t\t\t\t2010 | \n\t\t\t\t\t
Dismantlement method | \n\t\t\t\t\t\tMachine and Manual | \n\t\t\t\t\t\tMachine and Manual | \n\t\t\t\t\t\tMachine and Manual | \n\t\t\t\t\t\tManual | \n\t\t\t\t\t
Accountable entity and associated recycling costs | \n\t\t\t\t\t\tManufacturer | \n\t\t\t\t\t\tEnd users | \n\t\t\t\t\t\tManufacturer | \n\t\t\t\t\t\tManufacturer | \n\t\t\t\t\t
Operating principle | \n\t\t\t\t\t\tMarket-based | \n\t\t\t\t\t\tFund system (Air Bag, Freon gas & Automobile Shredder Residue or ASR) | \n\t\t\t\t\t\tMarket-based | \n\t\t\t\t\t\tMarket-based | \n\t\t\t\t\t
Institutional mechanism | \n\t\t\t\t\t\tMember states | \n\t\t\t\t\t\tJapan Automobile Recycling Promotion Center | \n\t\t\t\t\t\tKorea Environment Corporation Eco Assurance System (ECOAS) | \n\t\t\t\t\t\tChina National Resources Recycling Association | \n\t\t\t\t\t
Comparison of existing ELV laws
The above table reflects the uniqueness of Japan in terms of who is responsible in ELV recycling. The end users are the main actors as far as financial obligations are concerned such as payment of recycling fees. However, manufacturers are liable too like setting and publication of user fees and collection and disposal of shredder residues. Further, the above laws put both the manufacturers and users at the helm of recycling. This characteristic represents the necessary symbiosis that stakeholders play in resource recycling(Yu, Omura, & Yoshimura, 2008).
\n\t\tJapan has been implementing its ELV law since 2005. The vehicles covered by the law are four-wheeled passenger cars and commercial vehicles including mini-cars. The obligations of the car manufacturer comprise of collection and disposal of freon gas and airbags, collection and recycling of automobileshredder residue and setting and publication of user charges. Unlike other countries with ELV laws, financial responsibility is with the users where they are required to deposit a recycling fee at the time of sale. For old vehicles, deposit is required at the time of automobile inspection. The fees are managed by a fund management corporation (Kanari, Pineau, &Shallari, 2003).
\n\t\t\tCar recycling in Japan is not encompassing as it only covers three parts: airbag, freon and automobile shredder residue (ASR). As of the present, recycling rate in Japan is pegged at 95%. Table 1 shows the change in the generation of ELV and used car export of Japan for the period 2005 to 2008:
\n\t\t\t\n\t\t\t\t\t\t | \n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t
ELV Generation | \n\t\t\t\t\t\t305 | \n\t\t\t\t\t\t357 | \n\t\t\t\t\t\t371 | \n\t\t\t\t\t\t358 | \n\t\t\t\t\t
Cancelled registration of used car for export | \n\t\t\t\t\t\t107 | \n\t\t\t\t\t\t144 | \n\t\t\t\t\t\t161 | \n\t\t\t\t\t\t130 | \n\t\t\t\t\t
Sales of used car | \n\t\t\t\t\t\t811 | \n\t\t\t\t\t\t807 | \n\t\t\t\t\t\t753 | \n\t\t\t\t\t\t718 | \n\t\t\t\t\t
Source: Japan Ministry of Economy, Trade and Industry (METI)
ELV generation and used car export figures (Unit: 10,000 cars)
ELV generation grew rapidly from 2005 up to 2007 and a decline was noted in 2008. This was due to the introduction of an ELV bounty system or subsidy. However, it is not only the recycling rate of used car parts that is important but also the reduction in the volume of ASR because of its harmful effects to human health and the environment, in general. Table 5 reflects the recycling rates for both ASR and airbag:
\n\t\t\t\n\t\t\t\t\t\t | \n\t\t\t\t\t\t\t | \n\t\t\t\t\t|
\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t|
Goal (%) | \n\t\t\t\t\t\t70% (until 2015) | \n\t\t\t\t\t\t85% | \n\t\t\t\t\t
50% (until 2010) | \n\t\t\t\t\t||
30% (until 2005) | \n\t\t\t\t\t||
2008 | \n\t\t\t\t\t\t72.4-80.5 | \n\t\t\t\t\t\t94.1-94.9 | \n\t\t\t\t\t
2009 | \n\t\t\t\t\t\t64.278.0 | \n\t\t\t\t\t\t92.0-94.7 | \n\t\t\t\t\t
Source: Japan Ministry of Economy, Trade and Industry (METI)
Recycling rates for ASR and airbag in Japan
ASR remains a challenge for Japan as recycling rate is still not catching up with say airbags. The goal in the next five years is to increase the rate from 50% to 70% in 2015. In summary, the flow of automobile recycling in Japan is shown in the following figure:
\n\t\t\tFlow of automobile recycling in Japan
The above figure shows the efficiency of car recycling in Japan as used car parts are categorized. For example, reuse of used parts is about 20-30%, resource recycling is 50-55% while ASR recycling is 12%. Only five percent (5%) goes to the landfill(Yu, 2010).
\n\t\t\tRare earth metals are not the only valuable resource found in used cars. Plastic materials are also abundant. As part of the 3R Research and Development Project by Miyagi Prefecture in Japan,an experiment was conducted to demonstrate the time element involved in dismantling a used car with plastic as the main material recovered. Two types of used cars were dismantled: commercial car and luxury car. Methodologies were manual and machine dismantling (note that dismantling was done by non-experts). The following are the results:
\n\t\t\t\tMethodology | \n\t\t\t\t\t\t\tTime | \n\t\t\t\t\t\t\tResponsible | \n\t\t\t\t\t\t
Manual dismantling | \n\t\t\t\t\t\t\t15 minutes | \n\t\t\t\t\t\t\t1 person (non-expert) | \n\t\t\t\t\t\t
Machine dismantling | \n\t\t\t\t\t\t\t5 minutes | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t |
Separation and collecting plastic | \n\t\t\t\t\t\t\t10 minutes | \n\t\t\t\t\t\t\t1 person (non-expert) | \n\t\t\t\t\t\t
Dismantling of a commercial vehicle
Overall, the recovered amount of plastic was 20 kilograms. The following picture shows an image of a commercial vehicle dismantled by a machine.
\n\t\t\t\tCommercial vehicle to be dismantled for waste plastic recycling
Waste plastic recovered are shown below:
\n\t\t\t\tRecovered plastics from a commercial vehicle
It was observed that it is very easy to retrieve plastic materials from a commercial vehicle because of the simplicity of its interior and a single type of plastic was used. In addition, commercial vehicles are designed where it is easy to dismantle and recover plastic materials. On the other hand, a luxury car was dismantled with the following results:
\n\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t
Manual dismantling | \n\t\t\t\t\t\t\t40 minutes | \n\t\t\t\t\t\t\t2 persons (non-expert) | \n\t\t\t\t\t\t
Separation and collection | \n\t\t\t\t\t\t\t10 minutes | \n\t\t\t\t\t\t\t2 persons (non-expert) | \n\t\t\t\t\t\t
Dismantling of a luxury vehicle
The recovered amount of waste plastic was only five (5) kilograms compared to the commercial vehicle which was 20 kilograms. The reason was that a luxury vehicle has complex interior and is made of composite plastic materials. Also, many adjoining materials are used which complicates the dismantling process and is time consuming as well.
\n\t\t\t\tLuxury car dismantled for waste plastic recycling
Sample of recovered plastic materials is shown below:
\n\t\t\t\tWaste plastic from a luxury car
A dismantling experiment was also made for a small sedan with amount of plastic materials recovered shown below:
\n\t\t\t\tWaste plastics recovered from a small sedan
In summary, the amount of plastics recovered are as follows:
\n\t\t\t\t\n\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t
Weight (kg) | \n\t\t\t\t\t\t\t19.5 | \n\t\t\t\t\t\t\t2.90 | \n\t\t\t\t\t\t\t2.72 | \n\t\t\t\t\t\t\t0.52 | \n\t\t\t\t\t\t\t0.8 | \n\t\t\t\t\t\t\t26.44 | \n\t\t\t\t\t\t
The downside of the experiment was the time it took to dismantle the vehicle. The total amount of time consumed was 2.5 hours by four (4) non-expert persons with a plastic recovery of only 19.5 kilograms. It was concluded that waste plastic recycling from a small sedan is not good considering the lengthy dismantling time and poor recovery efficiency. Sample of plastics recovered are:
\n\t\t\t\tOn the left side are plastic pellets and on the right side is the internal part of a fender. In summary, the volume of plastics that can be recovered as well as the recovery efficiency depends on the type of vehicle. Figure 9 shows this type of variation.
\n\t\t\t\tRecovery efficiency for various types of vehicles
Based on the experiment, it can be concluded that for dismantling time, commercial vehicles are quick to be dismantled while minivans take time. In terms of volume of plastics recovered, relatively big cars like commercial vehicles, station wagons, and minivans have large amount of plastic materials.
\n\t\t\tChina’s economy is booming at an unprecedented rate. Looking at car possession alone, the following table shows the rate for the period 2005-2008:
\n\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t
2008 | \n\t\t\t\t\t\t\t49.75 | \n\t\t\t\t\t\t
2007 | \n\t\t\t\t\t\t\t43.58 | \n\t\t\t\t\t\t
2006 | \n\t\t\t\t\t\t\t36.97 | \n\t\t\t\t\t\t
2005 | \n\t\t\t\t\t\t\t31.6 | \n\t\t\t\t\t\t
Car possession rate in China (2005-08)
It is projected that the number of cars in China will increase a million per year in the near future due to increasing purchasing power and demand for personal transportation. From the data mentioned, it is also worth to examine the volume of cars that will become “used” in the near future. Using the following formulae:
\n\t\t\t\tWhere:
\n\t\t\t\tE number of presumed used cars at current year
\n\t\t\t\tA number of car possessions in previous year
\n\t\t\t\tB number of sales at current year
\n\t\t\t\tC number of car possession at current year
\n\t\t\t\tThus, the number of projected used car between 2005 and 2007 is as follows:
\n\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t
2007 | \n\t\t\t\t\t\t\t1.97 | \n\t\t\t\t\t\t\t4.5 | \n\t\t\t\t\t\t
2006 | \n\t\t\t\t\t\t\t1.79 | \n\t\t\t\t\t\t\t4.8 | \n\t\t\t\t\t\t
2005 | \n\t\t\t\t\t\t\t1.05 | \n\t\t\t\t\t\t\t3.3 | \n\t\t\t\t\t\t
Projected used cars in China (2005-2007)
It is, therefore, projected using the above data that China will have a large volume of used cars in the years to come.
\n\t\t\t\tThere are about 10.33 million passenger cars in China in 2001 with an engine displacement of 1,600 cc or less. In several years, these will become used cars. A study made in Shanghai City and the City of Beijing showed that recovery percentage of ELVs in China is only 20%. To validate this, Tohoku Universitythrough the environmental research fund of Sumitomo Foundation conducted a dismantling experiment of a car commonly sold in China as shown below:
\n\t\t\t\tPopular type of car sold in China
Considering the costs and difficulty involved in dismantling a new car, the research group selected a model closed to the picture as shown in Fig. 11.
\n\t\t\t\tReplacement car used for dismantlement
The recovered materials are as follows:
\n\t\t\t\tMaterial composition of a passenger car
If only 20% are to be recovered from the 7.2 million passenger cars sold in 2009, the projected economic loss is about 200 billion Chinese Yuan based on the metallic market price in China. Thus, the need to find ways to increase recovery rate of ELVs is necessary in the country where car possession is increasing at a rapid rate(Che, 2011).
\n\t\t\tThe importance of establishing a monitoring system in ELV recycling is essential in so many aspects. ELV recycling is about collating information or data needed to make it more efficient and useful for key stakeholders like manufacturers, recyclers and even those who manually recover used car parts. In the case of EU, it ensures the inventory of ELVs while in Korea, every ELV is checked including weight, type and main parts like bumper, fuel cell, engine, exterior and interior parts and so on (“Yu, Omura, & Yoshimura, 2008). In the case of Japan, monitoring focuses on airbag, Freon gas and ASR as mentioned earlier. The actual benefits of having a monitoring system abound. It helps in increasing dismantling efficiency when each part is identified i.e. weight, type, time consumed during dismantling and the amount. Having these data will be useful for sharing purposes between the manufacturers and recyclers (Yu, 2010). The data could also be used in life cycle analysis (LCA) and cost-benefit analysis (CBA). Another benefit is the potential of determining who is responsible for what and what roles should relevant stakeholders play in the whole gamut of ELV recycling.
\n\t\tAdvance technologyin used vehicle recovery and recycling does not necessarily apply in developing countries. They can recover resources using labor-intensive and manual strategies. Efficiency remains a question but in a research in China (Serrona, Yu &Che, 2010), a comparison between manual and machine-based dismantling was made. It was discovered that the former recovers more valuable parts which means more parts sold or recycled while the latter destroys more parts. In terms of value, manual dismantling provides more monetary compensation with more recovered parts. It also translates into more job opportunities and feeds people. The downside is that manual labor exposes people, engaged in the recovery of used car parts, to hazardous and toxic chemicals due to the absence of protective gears. It also consumes a lot of time. Manual recovery is good from the standpoint of local community participation. It allows them to be important stakeholders in the resource recycling ecosystem.
\n\t\t\tThere is no blueprint for ELV recycling across countries. Each country has its distinct characteristics of stakeholders and geographical location. The formulation of recycling laws should be based on the unique features of communities rather than applying blanket legislations which may or may not be effective at all. To come up with sound laws is to have good documentation of vehicle database i.e. registration, type of vehicle and other ELV data. Policy makers should take these into consideration in order to arrive at legislations that incorporate locality-based conditions, needs and characteristics into national policies.
\n\t\tUrban mining is driving ELV recycling into sustainable waste management. Just like solid waste management, various stakeholders or players are involved such as manufacturers, recyclers, users, waste reclaimers and the communities where waste recovery is done. There is a wide range of opportunities in this field and what is significant is that it has tremendous impact in terms of reducing toxic waste and providing local employment. In addition, it helps mitigate climate change by reducing greenhouse gases as recovering and recycling rare earth metals consume less energy than extracting raw metals. Closing the loop of rare earth metal utilization is a necessary attribute of sustainable consumption and production.
\n\t\t\tThe experiences of Japan and Korea in this aspect are worthy of emulation by other countries in East Asia. Developing countries, being the destination of used cars, should formulate legislations that will address the collection, trading and disposal of ELVs which consider local conditions and capacities. There is a vibrant informal ELV waste sector in the Philippines, for example, but there is neither database nor monitoring system of what comes to the country as other ELVs are brought in illegally. The challenge lies in coming up with a legislation that strongly advocates safe and sustainable resource recovery. The role of Japan and Korea is to provide technical assistance based on their best practices. And being the leading manufacturers of vehicles in Asia, they should incorporate LCA in the production process so that the end users in developing countries are able to responsibly dispose used cars. Likewise, regulatory institutions will be able to promote the development of appropriate, labor-intensive and simple technologies to recover and recycle used metal parts. This kind of symbiosis will allow for a sound partnership between these countries through job promotion and people to people exchange of ideas. To strengthen ELV recycling regulations, the following are recommended:
\n\t\t\tEstablishment of a resource recycling network that integrates economic and social dimension of ELV recycling. It should serve as a platform for exchanging innovative ideas, appropriate technologies and best practices in both developed and developing countries. There should also be component for capacity-building and community organizing to strengthen local waste reclaimers doing manual recovery. Organizing them into a legal entity will allow them to be accorded with rights, privileges and access to social and health services.
Build up a communication system between car manufacturers and recyclers. Currently, there is limited information exchange on ELV recycling processes. In the context of sustainable consumption and production, auto makers need to design cars that are easier to scrap and recover recyclable parts. Furthermore, they should provide the method of resource recovery including rare metals. And it is important to collect data on the content of materials as well as the cost and time involved in the recycling process.
In the formulation of ELV recycling legislations, lessons should be culled out from the best and bad practices of ELV recycling in Japan, Korea and even China. This includes an assessment of market principles used in the current system and how it will affect the future of resource recycling network worldwide. Policies should also be region-specific and localized to reflect in recognition of the distinct features of each locality or community.
The technological dimension of urban mining should be given attention with respect to local capacities and recovery efficiency. Based on dismantling experiments cited, manual dismantling is found to be effective in terms of recovering more resource materials compared to machine-based recovery. It is not always necessary that machines are effective since manual recycling in developing countries generates local jobs and increases the value of recovered parts. However, such method should ensure adequate protection of workers from exposure to toxic materials.
Engage constructive policy dialogues with exporting countries like Japan and Korea to discuss ways to ensure that used car importation comes with the necessary recovery system in developing countries. This will ensure that developing economies are not inundated with pollutive used cars and ELV recycling is done.
The smart polymers hydrogels are the class of functional polymers, which finds extensive use [1, 2] in diverse areas like agricultural, medical, pharmaceutical, effluent treatment, textile, etc. They have physicochemically crosslinked three-dimensional network, which are derived from water-soluble acrylic monomers, crosslinkers and natural pre-polymers. These smart hydrogels are capable of imbibing and retaining water or aqueous fluids such as urine, blood, electrolyte solution, etc. to the extent of 200 g to 1–2 kg of fluids without dissolving [3, 4, 5]. This hydrophilic nature of hydrogel leads to managing drought conditions in arid and semi-arid regions as a matrix for the controlled release of water and fertilizers [5]. To serve this, polymers with different chemical architecture are essential for diverse soil characteristics [5].
Agrochemicals such as primary and secondary fertilizers are used to hike crop yield with substantial quality foodstuff [6]. However, the traditional method of growing foodstuffs using synthetic fertilizers will not ensure a high-quality environment [6]. Depending on the method of application and climatic conditions, about 90% of conventionally applied fertilizers never reach their objectives to realize the desirable biological response at the precise time and in the quantities required [6]. Such a mode of application provides a higher initial concentration than required for quick results. The conventional method of fertilizer amendment provides an initial concentration far above that required for immediate results to ensure the availability of sufficient nutrients. But such overdosing will result in waste of fertilizers [6] and produce undesirable side effects in the environment. Hence, there is a need for more controlled application of fertilizer, affording lower amounts of active ingredients without diminishing the efficacy. Controlled-release formulations were used to maintain an effective local concentration of active ingredients in the soil and to reduce runoff [6]. Besides, the application frequency required in the growing season could be minimized through controlled release technology. The controlled release was defined [6] as a technique or a method by which water or active chemicals were made available to a specified target at a definite rate and duration designed to accomplish an intended effect [7, 8, 9, 10, 11, 12, 13, 14, 15]. The method of choice to achieve controlled release in a particular application depends on the cost, release rate, potency and properties of the active compounds [14, 15, 16]. This chapter addresses the synthesis, characterization and controlled release applications of synthetic and natural polymer modified hydrogels in agriculture as matrices [16], different types of hydrogel used for controlled release, advantages, limitations and challenges.
The smart hydrogels with controlled release characteristics have been prepared either from water-soluble acrylic monomers, crosslinkers and modified natural polymer by grafting.
The hydrogels with good swelling ability are synthesized from water-soluble hydrophilic acrylic monomers such as acrylamide, acrylic acid, acrylates, itaconic acid, etc. using suitable initiators and crosslinkers through radical or photochemical polymerization methods [17]. This will be achieved either by solution or suspension or emulsion or bulk polymerization methods [17]. Free-radical polymerization mechanism is predominantly employed to synthesize hydrogel using olefinic monomers. The initiation of monomers is carried out by the initiators such as peroxides (benzoyl or t-butyl peroxides), azo-compounds (azobisisobutyronitrile) and persulphates. Peroxides and peroxy compounds can facilitate ambient temperature polymerization under the influence of tetramethylene diamine, sodium metabisulfite/ferrous salts, triethylamine, etc. [17, 18]. Benzyl alcohol, ethanol, water, and ethanol-water mixtures are commonly used solvents to achieve solution polymerization. The monomers (Table 1), cross-linkers (Table 2) and natural polymers (Table 3) that are used for hydrogel synthesis are given in the respective Tables.
Typical monomers used for hydrogel synthesis.
Typical crosslinkers used for hydrogel synthesis.
The representative natural pre polymers used for hydrogel synthesis.
Water swellable hydrophilic hydrogel polymer can also be synthesized by performing appropriate chemical modification of natural polymers such as gelatin, starch, alginate, cellulose, chitosan, pectin, etc. via grafting using acrylic monomers. In-situ incorporation of micronutrient (boron) on acrylic acid grafted guar gum-based hydrogel [19], acrylic monomers grafted chitosan hydrogel [20], urea loaded cellulose [21], carboxymethylcellulose-hydroxyethylcellulose cross-linked with citric acid [22], etc. can also be used as matrices for the controlled release of fertilizers and water in agricultural field.
The potential applicability [23] of smart polymers are gauged based on their chemical structure, the extent of chemical and physical crosslinking, crosslink density, mechanical properties, degrees of swelling (hydrophilicity), release characteristics, hydrophobicity, surface morphology, biodegradability, biocompatibility, glass-transition temperature, thermal stability, photo-stability, bio-resorbability, interaction with biological fluids, environmental sensitivity, dielectric properties, toxicity, the toxicity of the degraded products, etc. For instance, the nature of functional groups, crystallization deformation of polymers, biodegradation, moisture uptake properties, nature of interactions between components are evaluated using Fourier Transform Infrared Analysis (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy. The modification after polymerization such as chemical composition, grain size, the extent of crosslinking, pore size, pore volume are evaluated using Atomic Force Microscopy (AFM) or Scanning Electron Microscopy (SEM) and X-ray diffraction analysis. The oxidative thermal degradation, glass transition temperature, lifetime prediction, melting point, etc. are assessed through Thermal Analysis (TGA and DSC). The mechanical characteristics such as tensile strength and elastic moduli and strain are evaluated using a tensile-compressive tester.
The swelling ability of hydrogel is a significant characteristic for field application. The absorption capacity of the hydrogel can be evaluated [23] gravimetrically at successive time intervals using tea-bag, sieves, centrifugal, volumetric, microwave, gravimetric, NMR, DSC methods based on the required precision. The extent of swelling (DS) was measured using Eq. (1) by performing triplicate measurements.
The weight of dried (
The extent of water absorption under load is determined by performing AUL of hydrogel samples [24] using the Eq. (2). The AUL test will display the absorption capacity of smart polymer hydrogel under stressed conditions (load) and ionic strength.
The quantum of fertilizer absorption and release characteristics of smart hydrogels are measured based on Eq. (3). The percentage release of fertilizer from the loaded hydrogels are measured gravimetrically [12]. This procedure was followed for every two-day interval to ensure maximum fertilizer release. The percentage of urea/potash release was calculated [12] using Eq. (3).
The amount of fertilizer released from the hydrogel in 2 and ith ml are represented by W0 and (ΔW)i respectively. The number of nutrient releases at different time intervals for the single experiment is denoted by the term “n”.
The rate of nutrient absorption by the plants depends on various parameters such as plant age, nature of fertilizers, and the concentration of fertilizers. However, the micronutrients are supplied as chelates or complexes (using synthetic complexing agents such as salicylic, lactic, formic, citric, succinic, propionic, ascorbic, tartaric and gluconic acids and their sodium, potassium and ammonium salts. Amino acids such as glutamine cysteine, glycine, and lignosulfonates can also be used as complexing agents [25]. The water, nutrients uptake and release behavior of hydrogels are regulated by their chemical constituents namely sulfonic acid, amide, hydroxyl, amine, carboxylic acid, carboxylate groups, etc.
The uptake and release mechanisms are clearly understood by analyzing the transport kinetics. The movement of solvent and solute either into or out of hydrogel is also regulated by the shrinking and swelling of hydrogels. The second-order kinetic model [Eq. (4)] was used to explain the swelling of hydrogel [23].
where, M: uptake at time t, M∞: uptake at equilibrium condition, and ks: kinetic rate constant.
The swelling rate (
A random molecular process causes the movements of solvent or solute molecules from one part to another part of hydrogels. Further, this movement is also influenced by temperature, pressure, solute size and viscosity. Generally, in hydrogel water molecules diffusion is connected to the extent of polymer-solvent interactions. Based on hydrogel relaxation rate, the diffusion is categorized as non-Fickian and Fickian [26], and the power-law Eq. (6) is used to evaluate the penetration characteristics of solvent into the hydrogel [26].
The value of diffusion exponent (n) is ranged from 0.5 to 1 and the parameter k represents the rate constant.
The diffusion mechanism [26] of solution in the hydrogel during network collapse or swelling was analyzed using Fick’s law. Fickian diffusion was noticed when the operating temperature of the system was greater than the glass transition temperature (
The value of ‘n’ provides the diffusion characteristics, for instance, if n = 0.5 in Eq. (6) Fickian diffusion is followed, and the ‘n’ values lie between 1 and 0.5 non-Fickian (anomalous) transport mechanism is followed. Further, non-Fickian model was noticed below glass transition of the hydrogel.
The substantial foodstuff production requires an adequate amount of primary and secondary nutrients [6] along with water during cultivation. To achieve expected yield farmers used to feed an additional amount of fertilizers than the required quantity [6] during each amendment. However, 90% of the applied fertilizers are going as waste due to different climatic conditions and the application method [6]. An excess dose of fertilizers leads to economic losses, toxicity problems and effects on aquatic organisms [6] which cause uninvited effects such as water and soil pollution. Hence, there is a necessity to adopt the method, which facilitates the controlled release of fertilizers without affecting efficacy. An execution of controlled release using polymer based matrix is being used for a long time [6]. The loaded fertilizers have been released through chemical cleavage of the polymer-active agents or by depolymerization reaction (originated other factors) [6]. However, the implementation of a controlled release technique for the particular application depends on the factors namely release rate, cost, effectiveness and properties of synthetic fertilizers.
In agricultural field, smart hydrogels have discharged numerous applications [27] and the notable merits are minimum use of fertilizers and water through controlled a release mechanism. The list of noteworthy advantages of hydrogel amendment in the soil is displayed in Figure 1. However, hydrogels used for the controlled release of fertilizers and water in the field must have
High water retaining ability with slow-release behavior
Excellent efficiency
Appreciable permeability and infiltration rate
Highly stable enough under various environmental conditions for the prolonged use
Reduced frequency of irrigation
Ability to undergo biodegradation without affecting soil fertility
Enhanced plant growth in arid and semiarid conditions
Advantages of hydrogel in field.
The use of smart hydrogels in agricultural sector have attracted great attention as water management material in soil and matrices for the controlled release of primary and secondary fertilizers. The release rates of hydrogels [23, 27] are depends on the functional groups that are present in the polymer, functionality of crosslinker, pH, temperature, ionic strength of the medium, etc. Besides, the incorporation of natural pre-polymers in synthetic polymer hydrogel will bring down the operation cost, since they are readily available at a low cost and highly biodegradable. Nevertheless, natural polymer incorporation may induce a few limitations such as the lack of solubility of monomers in aqueous and non-aqueous solvents during hydrogel synthesis [16]. This characteristic behavior will result in excess utilization of pre-polymers to enhance agricultural yield.
The additional expected physicochemical and mechanical properties from the synthesized hydrogel for field applications are good stability during swelling (without dissolving), photostability, ability to uptake and hold maximum water with good swelling rate, particle size, maximum fertilizer uptake, porosity, odorless, neutral pH, colorless, low residual monomer content, non-toxicity, biodegradability without yielding toxic reside, and low cost [28, 29]. However, it should be remembered that the synthesis of hydrogel with all these features is difficult to achieve. However, some of its features namely porosity, stimuli responsiveness (pH and temperature), residual monomer content and swellability [30, 31, 32] are fine-tunable. The extent of hydrogel swellability, which are amended in the soil can be fine-tuned based on the requirement by making modification in the functional groups such as −NH2, −COOH, −OH, −CONH2, −CONH− and –SO3H. Besides, osmotic pressure, movable counter ions and capillary effect have also influenced swelling and release phenomena [33]. During swelling, the process of water uptake by the hydrogel will follow multiple steps that include hydration of polar hydrophilic and hydrophobic groups leading to the formation of primary and secondary bound water respectively. Meanwhile, infinite dilution of the hydrogel network will be resisted by the formation of either chemical or physical cross-links. Hence, the water molecules that are entering into the network during the initial and equilibrium stages are known as total bound and bulk water/free water respectively. During swelling these water molecules shall occupy the gaps available between chains and the midpoint of pores. The quantum of water uptake by the hydrogel networks is influenced by various parameters such as temperature, pH, nature of interactions, etc. that exist between networks and water molecules [33]. The list of representative hydrogels that are used as water-retaining agents and matrices for the controlled release of nitrate, potash, phosphate fertilizers are presented in Tables 4–7.
Representative hydrogel | Reference |
---|---|
Starch-modified poly(acrylic acid) | [15] |
Hydrogels based on polyacrylamide and natural cashew tree gum | [34] |
Wheat straw cellulose hydrogel based hydrogel | [35] |
Hyaluronate-Hydroxyethyl acrylate blend | [36] |
Acrylic acid and acrylamide copolymers | [37] |
Polyacrylamide based hydrogel | [38] |
Guar gum-g-poly(sodium acrylate) | [39] |
Radiation induced crosslinked polyacrylamide | [40] |
Glycerol and poly(vinyl alcohol) hydrogel | [41] |
Gum ghatti-poly(acrylic acid–aniline) hydrogels | [42] |
Acrylamide and hyper-branched polyethyleneimine based hydrogel | [43] |
Acrylic acid-co-acrylic amide based hydrogel | [44] |
Poly(acrylamide-co-acrylic Acid)/AlZnFe2O4 | [45] |
Poly(ethylene glycol) and Poly(acrylate) copolymer | [46] |
Partially neutralized acrylic acid and NVP | [47] |
Oxyethylene segments of poly(ester-amide) and poly(tartaramide) | [48] |
Aluminum sulfate octadecahydrate crosslinked carboxymethyl cellulose and aluminum sulfate octadecahydrate crosslinked starch | [49] |
Modified poly(ethylene glycol) crosslinked with poly(sodium acrylate) | [50] |
Poly(acrylic acid) grafted on carboxymethyl chitosan copolymer | [51] |
Hydrogel used as soil conditioner and water retention material in soil.
Typical hydrogel | Reference |
---|---|
Microwave-mediated biochar-hydrogel composites | [52] |
Polyvinylpyrrolidone (PVP)/carboxylmethyl cellulose | [53] |
Acrylamide and acrylic acid based hydrogels | [54] |
Glutaraldehyde crosslinked chitosan-poly(vinylalcohol) hydogel | [55] |
Borassus aethiopum starch and Maesopsis eminii hydrogels | [56] |
Poly(acrylonitril)-based poly acrylic acid hydrogels, | [57] |
Acrylamide and N-hydroxymethyl acrylamide hydrogel | [58] |
Natural rubber, cassava starch crosslinked by glutaraldehyde hydrogel | [59] |
Starch phosphate carbamate hydrogel | [60] |
Starch cross-linked acrylic acid and acrylamide hydrogel | [61] |
Poly (acrylamide | [62] |
Poly(maleic anhydride | [63] |
Poly(acrylic acid)/attapulgite/sodium humate composite hydrogel | [64] |
Poly(acrylamide) and methylcellulose based hydrogels | [65] |
N,N1-MBA crosslinked acrylic acid | [12] |
Representative Hydrogel used for the controlled release of nitrogen fertilizer.
Chemical nature of hydrogel | Reference |
---|---|
Biodegradable Gelatin-Tapoica/polyacrylamide | [66] |
N,N\'-MBA crosslinked starch hydrogel | [67] |
Poly(vinyl alcohol)/chitosan crosslinked with glutaraldehyde | [68] |
Methylcellulose and hydroxypropyl methylcellulose based hydrogel | [69] |
Arabic gum-based hydrogel | [70] |
Pine resin backbone based hydrogel | [71] |
Clay-based nanocomposites hydrogel | [72] |
κ-carrageenan-based hydrogel | [73] |
poly(lactic acid)/cellulose-based hydrogel composite | [74] |
poly(acrylic acid-co-acrylamide)/kaolin hydrogel | [75] |
Typical hydrogels used as matrices for the controlled release of potassium.
Name of the hydrogel | Reference |
---|---|
Carboxymethyl cellulose based hydrogel | [76] |
Alginate-cellulose nanofibers–poly(vinyl alcohol) hydrogel | [77] |
Hybrid nanocomposite banana peel cellulose and layered double hydroxides nano-sheets | [78] |
Carboxymethyl starch-g-polyacrylamide | [79] |
pH sensitive sodium alginate, acrylic acid, and acrylamide based hydrogel | [80] |
Biodegradable crosslinked acrylic acid based hydrogel | [81] |
sulfonated-carboxymethyl cellulose, acrylic acid and polyvinylpyrrolidone based hydrogel | [82] |
Poly(acrylic acid) and sugarcane bagasse hydrogel | [83] |
Poly(vinylalcohol)-phosphate gels | [84] |
Alginate-graft-polyacrylamide hydrogel | [13] |
Representative hydrogels used for the controlled release of phosphate fertilizer.
Smart hydrogel amendment in the soil during cultivation process will alter the hydraulic conductivity and pore size of soil to some extent due to water absorption [85, 86]. However, it will improve residual and saturated water content, which results in the reduction of subsequent water loss and infiltration due to percolation, this will facilitate aeration in soil due to expansion and contraction of hydrogel through absorption and evaporation [85]. The suitability of hydrogel for semi-arid and arid regions was due to the release of water and fertilizers with reference to environmental temperature, which results in increased survival [85] of plants. Besides, the hydrogel amendment has reduced the uptake of toxic metals and soil salinity by plants [87, 88].
The practical applicability of hydrogel in field applications is dependent on safety, toxicity and eco-friendly degradability under soil conditions after its service and other environmental issues. Most of the hydrogels used in agricultural sector have stable service life (5–7 years), but their degradability is suspected. Hydrogels amended in the soil will experience stress from various factors such as microbes, light, pH, temperature, etc. The degradability of hydrogels depends on their structures and other environmental factors such as intensity of light, soil microbes, heat, pH, etc. The degradability of hydrogels could be attained by incorporating favorable functional groups such as ester, amide, urethane, anhydride, glycocidic (ether), urea, ortho-ester, carbonate, etc. in the backbone. The degradation sequence of polymers have predicted as anhydride > ester> orthoester> carbonate> urea>urethane> ether [89].
The monomers of hydrogels are known to be toxic and carcinogenic, but the polymer derived from the same monomers are proved to be non-toxic [18]. This characteristic behavior could be attributed to low boiling point and the low molecular weight of acrylic monomers and crosslinkers, which may effortlessly enter into the human body through skin absorption and inhalation [90, 91]. The studies have also recorded that these acrylic monomers imposed wide a range of health effects such as skin and eye irritation, allergic action, asthma, nerves problem, internal organ toxicity and impacts on fertility [90, 91]. The contentious exposures of acrylates will yield acrylic acid [90, 91] in the human body during metabolic activity. However, the crosslinked hydrogels will not cause any harmful effects on living organisms due to their insolubility and non-volatile nature [90, 91].
The chapter is focused on the development of smart hydrogels derived from synthetic monomers and natural pre-polymer for agricultural application as water retaining material and matrices for the controlled release of fertilizers. However, in the majority of the report, the mechanical properties of those hydrogels are not good enough for prolonged application in the field. Hence, this chapter addressed the route in which the mechanical properties of such hydrogel are fine-tuned. Besides, it focused on the typical hydrogels that are used for the controlled release of water, urea, potash and phosphate fertilizers, their advantages in the field, effects on the hydraulic conductivity of soil and their safety aspects.
The authors would like to thank Sri Ramakrishana Mission Vidyalaya College of Arts, and Science, Coimbatore and Bannari Amman Institute of Technology, Sathyamangalam, for encouraging this work.
The authors declare that no conflicts of interests.
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All published Book Chapters are licensed under a Creative Commons Attribution 3.0 Unported License. Monographs are licensed under the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) license granted to all others. Our Copyright Policy aims to guarantee that original material is published while at the same time giving significant freedom to our Authors. IntechOpen upholds a flexible Copyright Policy meaning that there is no copyright transfer to the publisher and Authors hold exclusive copyright to their work.
\n\n\n\nWith the purpose of protecting our Authors' copyright and the transparent reuse of Open Access content, IntechOpen has developed an Attribution Policy for works published under Creative Commons licenses.
\n\n\n\nIntechOpen is committed to disseminating high-quality scientific research in a manner that exemplifies the best practice in scholarly publishing. IntechOpen is an official member of the Committee on Publication Ethics (COPE), which advocates the maintenance of the highest ethical standards for all parties involved in the act of publishing, including Authors, Academic Editors of the book, Peer Reviewers, the publisher and Societies, where applicable.
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\n\n\n\nTo identify instances of fraud and misconduct during the publishing process, IntechOpen implements a robust policy governing such occurrences. In line with our general commitment to openness, and in order to maintain the highest scientific standards, we are committed to transparency about our editorial policy regarding retractions and corrections.
\n\n\n\nWhen faced with potential misconduct, IntechOpen accepts its responsibility to maintain the integrity of the academic record. For particularly complex cases, IntechOpen might ask for the assistance of formal industry bodies or seek advice from an appropriate team of advisors.
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\n\nIntechOpen publishes books in the English language. If you are interested in the translation of Book Chapters, please check IntechOpen's Translation Policy.
\n\n\n\nIn line with the Principles of Transparency and Best Practice in Scholarly Publishing, you can access a more detailed description of IntechOpen's Advertising Policy.
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\n\n\n\nAll chapters will be published via IntechOpen's 'Online First' service meaning chapters will be published individually, immediately after review and before the entire book is ready for publication, allowing content to be shared, searched and cited straightaway, thereby generating early stage interest and momentum for your research
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\n\nChapters will remain listed as Online First until the final versions of the books are published online. Following publication of the full monograph, Chapters will be redirected from the Online First version and will be available only through the final link of the official published page.
\n\nYou are invited to download, use, reproduce, make derivative works of, display, distribute and cite the Online First works. You can find "How to Cite and Reference" by following the link at the end of each online book chapter. Please be aware that it is possible that further editing and changes might be made before the final release of the book.
\n\nIf there are supplemental materials to the chapter, these will be published at the time the final book is published online.
\n\nReaders and Authors can notify us if they find any errors in the works published under Online First. All major errors will be accompanied by a separate correction notice, erratum or corrigendum (Retraction and Correction Policy.)
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This chapter explains briefly the fire retardation of wood by using fire retardant coatings.",book:{id:"5827",slug:"new-technologies-in-protective-coatings",title:"New Technologies in Protective Coatings",fullTitle:"New Technologies in Protective Coatings"},signatures:"Thirumal Mariappan",authors:[{id:"198114",title:"Dr.",name:"Thirumal",middleName:null,surname:"Mariappan",slug:"thirumal-mariappan",fullName:"Thirumal Mariappan"}]},{id:"75967",title:"Recent Advances in Ceramic Materials for Dentistry",slug:"recent-advances-in-ceramic-materials-for-dentistry",totalDownloads:811,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Dental ceramics constitute a heterogeneous group of materials with desirable optical and mechanical proprieties combined with chemical stability. They are inorganic non-metallic materials used in several applications. These materials are biocompatible to tissue, highly esthetic, with satisfying resistance to tensile and shear stress. Over the past years, several developments in new ceramic materials in dental restoration were achieved, including processing techniques and high mechanical properties. Thus, concepts on the structure and strengthening mechanisms of dental ceramic materials are also discussed. The dental practitioner requires best knowledge concerning indications, limitations, and correct use of started materials. The purpose of this book chapter is to overview advances in new ceramic materials and processes, which are used in dentistry. The properties of these materials are also discussed.",book:{id:"9894",slug:"advanced-ceramic-materials",title:"Advanced Ceramic Materials",fullTitle:"Advanced Ceramic Materials"},signatures:"Mohsen Mhadhbi, Faïçal Khlissa and Chaker Bouzidi",authors:[{id:"228366",title:"Dr.",name:"Mohsen",middleName:null,surname:"Mhadhbi",slug:"mohsen-mhadhbi",fullName:"Mohsen Mhadhbi"},{id:"324375",title:"Dr.",name:"Faïçal",middleName:null,surname:"Khlissa",slug:"faical-khlissa",fullName:"Faïçal Khlissa"},{id:"324535",title:"Dr.",name:"Chaker",middleName:null,surname:"Bouzidi",slug:"chaker-bouzidi",fullName:"Chaker Bouzidi"}]},{id:"66615",title:"Survey of Bauxite Resources, Alumina Industry and the Prospects of the Production of Geopolymer Composites from the Resulting by-product",slug:"survey-of-bauxite-resources-alumina-industry-and-the-prospects-of-the-production-of-geopolymer-compo",totalDownloads:1231,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Guinea is endowed with huge mineral resources. Several geological surveys have identified bauxite, iron, gold, diamond, and several metal ores. Because of the diversity and the magnitude of its resources, the country is referred to as a geological scandal. Nowadays the aluminum industry is still at the quarrying stage of bauxite, the main raw material that is converted into alumina and further to aluminum. Approximately 35–40% of the processed bauxite ore goes into the waste as alkaline red mud RM slurry which consists of 15–40% solids. RM and other industrial wastes material such as fly ash FA, rice husk ash RHA, that poses environmental hazards can be mixed to make them apt for usage in engineering applications. Geopolymers GP represent a new class of materials consisting of Al2O3▬SiO2-based material suitable for several engineering application. The present chapter presents the bauxitic potential of Guinea, the subsequent developing alumina industry. 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He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"436430",title:"Associate Prof.",name:"Mesut",middleName:null,surname:"Işık",slug:"mesut-isik",fullName:"Mesut Işık",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/436430/images/19686_n.jpg",biography:null,institutionString:null,institution:{name:"Bilecik University",country:{name:"Turkey"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. He continues to lead research projects on developing new therapies for liver, skin disorders, and cancer. Dr. Badria was listed among the world’s top 2% of scientists in medicinal and biomolecular chemistry in 2019 and 2020. He is a member of the Arab Development Fund, Kuwait; International Cell Research Organization–United Nations Educational, Scientific and Cultural Organization (ICRO–UNESCO), Chile; and UNESCO Biotechnology France",institutionString:"Mansoura University",institution:{name:"Mansoura University",country:{name:"Egypt"}}},{id:"329385",title:"Dr.",name:"Rajesh K.",middleName:"Kumar",surname:"Singh",slug:"rajesh-k.-singh",fullName:"Rajesh K. Singh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329385/images/system/329385.png",biography:"Dr. Singh received a BPharm (2003) and MPharm (2005) from Panjab University, Chandigarh, India, and a Ph.D. (2013) from Punjab Technical University (PTU), Jalandhar, India. He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null}]}},subseries:{item:{id:"22",type:"subseries",title:"Applied Intelligence",keywords:"Machine Learning, Intelligence Algorithms, Data Science, Artificial Intelligence, Applications on Applied Intelligence",scope:"This field is the key in the current industrial revolution (Industry 4.0), where the new models and developments are based on the knowledge generation on applied intelligence. The motor of the society is the industry and the research of this topic has to be empowered in order to increase and improve the quality of our lives.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/22.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11418,editor:{id:"27170",title:"Prof.",name:"Carlos",middleName:"M.",surname:"Travieso-Gonzalez",slug:"carlos-travieso-gonzalez",fullName:"Carlos Travieso-Gonzalez",profilePictureURL:"https://mts.intechopen.com/storage/users/27170/images/system/27170.jpeg",biography:"Carlos M. Travieso-González received his MSc degree in Telecommunication Engineering at Polytechnic University of Catalonia (UPC), Spain in 1997, and his Ph.D. degree in 2002 at the University of Las Palmas de Gran Canaria (ULPGC-Spain). He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. He is the founder of The IEEE IWOBI conference series and the president of its Steering Committee, as well as the founder of both the InnoEducaTIC and APPIS conference series. He is an evaluator of project proposals for the European Union (H2020), Medical Research Council (MRC, UK), Spanish Government (ANECA, Spain), Research National Agency (ANR, France), DAAD (Germany), Argentinian Government, and the Colombian Institutions. He has been a reviewer in different indexed international journals (<70) and conferences (<250) since 2001. He has been a member of the IASTED Technical Committee on Image Processing from 2007 and a member of the IASTED Technical Committee on Artificial Intelligence and Expert Systems from 2011. \n\nHe has held the general chair position for the following: ACM-APPIS (2020, 2021), IEEE-IWOBI (2019, 2020 and 2020), A PPIS (2018, 2019), IEEE-IWOBI (2014, 2015, 2017, 2018), InnoEducaTIC (2014, 2017), IEEE-INES (2013), NoLISP (2011), JRBP (2012), and IEEE-ICCST (2005)\n\nHe is an associate editor of the Computational Intelligence and Neuroscience Journal (Hindawi – Q2 JCR-ISI). He was vice dean from 2004 to 2010 in the Higher Technical School of Telecommunication Engineers at ULPGC and the vice dean of Graduate and Postgraduate Studies from March 2013 to November 2017. 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Possible contributions can address (but are not limited to) the following research topics: Bioinspired design and control of exoskeletons, orthoses, and prostheses; Experimental evaluation of the effect of assistive devices (e.g., influence on gait, balance, and neuromuscular system); Bioinspired technologies for rehabilitation, including clinical studies reporting evaluations; Application of neuromuscular and biomechanical models to the development of bioinspired technology.',annualVolume:11404,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/8.jpg",editor:{id:"144937",title:"Prof.",name:"Adriano",middleName:"De Oliveira",surname:"Andrade",fullName:"Adriano Andrade",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRC8QQAW/Profile_Picture_1625219101815",institutionString:null,institution:{name:"Federal University of Uberlândia",institutionURL:null,country:{name:"Brazil"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"49517",title:"Prof.",name:"Hitoshi",middleName:null,surname:"Tsunashima",fullName:"Hitoshi Tsunashima",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYTP4QAO/Profile_Picture_1625819726528",institutionString:null,institution:{name:"Nihon University",institutionURL:null,country:{name:"Japan"}}},{id:"425354",title:"Dr.",name:"Marcus",middleName:"Fraga",surname:"Vieira",fullName:"Marcus Vieira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003BJSgIQAX/Profile_Picture_1627904687309",institutionString:null,institution:{name:"Universidade Federal de Goiás",institutionURL:null,country:{name:"Brazil"}}},{id:"196746",title:"Dr.",name:"Ramana",middleName:null,surname:"Vinjamuri",fullName:"Ramana Vinjamuri",profilePictureURL:"https://mts.intechopen.com/storage/users/196746/images/system/196746.jpeg",institutionString:"University of Maryland, Baltimore County",institution:{name:"University of Maryland, Baltimore County",institutionURL:null,country:{name:"United States of America"}}}]},{id:"9",title:"Biotechnology - Biosensors, Biomaterials and Tissue Engineering",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering",scope:"The Biotechnology - Biosensors, Biomaterials and Tissue Engineering topic within the Biomedical Engineering Series aims to rapidly publish contributions on all aspects of biotechnology, biosensors, biomaterial and tissue engineering. We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",annualVolume:11405,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",editor:{id:"126286",title:"Dr.",name:"Luis",middleName:"Jesús",surname:"Villarreal-Gómez",fullName:"Luis Villarreal-Gómez",profilePictureURL:"https://mts.intechopen.com/storage/users/126286/images/system/126286.jpg",institutionString:null,institution:{name:"Autonomous University of Baja California",institutionURL:null,country:{name:"Mexico"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"35539",title:"Dr.",name:"Cecilia",middleName:null,surname:"Cristea",fullName:"Cecilia Cristea",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYQ65QAG/Profile_Picture_1621007741527",institutionString:null,institution:{name:"Iuliu Hațieganu University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"40735",title:"Dr.",name:"Gil",middleName:"Alberto Batista",surname:"Gonçalves",fullName:"Gil Gonçalves",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYRLGQA4/Profile_Picture_1628492612759",institutionString:null,institution:{name:"University of Aveiro",institutionURL:null,country:{name:"Portugal"}}},{id:"211725",title:"Associate Prof.",name:"Johann F.",middleName:null,surname:"Osma",fullName:"Johann F. 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