Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
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We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
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Throughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\n
We wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
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Cancer stem cells may or may not be a subset of slowly dividing cancer cells that both disseminate cancers and defy oncotoxic drugs and radiation directed at rapidly dividing bulk cancer cells, but research on cancer stem cells has paid dividends for cancer prevention, detection, targeted treatment, and improved prognosis.",isbn:null,printIsbn:"978-953-307-580-8",pdfIsbn:"978-953-51-6444-9",doi:"10.5772/734",price:159,priceEur:175,priceUsd:205,slug:"cancer-stem-cells-the-cutting-edge",numberOfPages:632,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"464a7be74679b09faeb4aef72c3cd3a6",bookSignature:"Stanley Shostak",publishedDate:"August 1st 2011",coverURL:"https://cdn.intechopen.com/books/images_new/209.jpg",numberOfDownloads:69203,numberOfWosCitations:39,numberOfCrossrefCitations:0,numberOfCrossrefCitationsByBook:null,numberOfDimensionsCitations:0,numberOfDimensionsCitationsByBook:0,hasAltmetrics:0,numberOfTotalCitations:39,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"October 19th 2010",dateEndSecondStepPublish:"November 16th 2010",dateEndThirdStepPublish:"March 23rd 2011",dateEndFourthStepPublish:"April 22nd 2011",dateEndFifthStepPublish:"June 21st 2011",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"28104",title:"Prof.",name:"Stanley",middleName:null,surname:"Shostak",slug:"stanley-shostak",fullName:"Stanley Shostak",profilePictureURL:"https://mts.intechopen.com/storage/users/28104/images/1561_n.jpg",biography:"For fifty years, I have studied the evolution of growth’s integration with form. Hydras’ ability to move excess cells into buds was my model for cancer’s ability to support metastasis (e.g., Vegetative reproduction by budding in Hydra: A perspective on tumors. Perspectives in Biology and Medicine, 20:545–68; 1977; “Hydra and cancer: Immortality and budding,” pp. 275-86 in C.J. Dawe, J.C. Harshbarger, S. Kondo, T. Sugimura, and S. Takayama, eds., Phyletic Approaches to Cancer. Tokyo: Sci. Soc. 1981). I have concentrated on the origins of stem cells (Symbiogenetic origins of cnidarian cnidocysts. Symbiosis, 19:1–29; 1995 [with V. Kolluri]; “Speculation on the Evolution of Stem Cells,” Breast Disease, 29:3–13; 2007–8) and have developed my ideas further in books (Evolution of Death: Why We Are Living Longer. Albany: SUNY Press; 2006; Becoming Immortal: Combining Cloning and Stem-Cell Therapy. Albany: SUNY Press; 2002; Evolution of Sameness and Difference: Perspectives on the Human Genome Project. Amsterdam: Harwood Academic Publishers, 1999; Death of Life: The Legacy of Molecular Biology. 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1. Introduction
Methods of direct quasioptical vision and holography can be used in systems of ultrasonic vision to form high-quality images of objects (V. A. Zvereva, I. N. Stepanova, 1979). The formation of images in the ultrasonic wavelength bands has certain specific features, namely: the sizes of the image-forming systems and of the objects of observation are comparable with wavelength, so that the diffraction nature of the image must be taken into account in calculating the structure of the image.
Both in the ultrasonic and optical wave bands, dielectric lenses and mirror antennas are used to format images of objects (Zelkin E. T., Petrova R. A., 1974). The application of these focusing elements does not solve the problem completely since objective lenses with very large apertures – on the order of several meters – are needed to obtain high-quality ultrasonic images. Fabrication of such lenses involves considerable technological problems because the more practical ones are lenses with a small refractive coefficient and focal length equal to the aperture (Minin I.V., Minin O.V., 1992).
The thickness of the lens is several tens of percent of aperture size. Therefore the mass of such a ultrasonic objective is considerable. Energy losses connected with absorption of the transmitted radiation in the lens material are high. Using mirrors to generate ultrasound images is constrained by the fact that the object and the image area on the same side of the focusing system.
When building a real system for generating ultrasonic images of objects with the resolution depth greater than given by a conventional image, one must scan the object in three coordinates. For instance, using a mechanical scanning into the depth of the object makes it difficult, and sometimes impossible, to obtain the entire radio image of the object in real time.
A realistic system of visualization of three-dimensional objects in the ultrasound wave band must provide scanning of a volume of space of at least (105 - 108)3, and it is required that objects whose characteristic sizes come to several wavelength must be reliably identified in this volume. Therefore, the system of visualization must provide resolving power in the object space of about 5-6 mm. In classical systems of image generation, that is, in systems that use lenses and mirrors as image formatting elements, high transversal resolution (relative to the optical axis of the objective lens) is achieved at high values of numerical aperture. However, as the resolution on the object increases, the resolution depth of the lens (and therefore, the longitudinal resolution) decreases, and if we take into account that
dlongit~2λ(F/D)2anddtransv~1.22λ(F/D),E1
it is not difficult to arrive at the following estimate:
dlongit~ 1.3d2transv/λ.E2
A contradiction thus arises: trying to increase resolution on the object in the transverse direction, the resolution depth of the image-formatting systems decreases following square law, that is, the problem of generating a ultrasonic image of a three-dimensional object whose extension in the longitudinal direction is several tens of wavelengths, becomes practically unresolvable in this approach because of the high spatial resolution.
Generation of quasioptical ultrasonic images of objects
We shall consider now how to obtain images of objects with resolution depth greater than that provided by the quasioptical system.
The problem may be solved in this case by applying the so-called layer-by-layer scanning of the object. The essence of this technique is that at each given moment of time a flat two-dimensional radio image is constructed of one layer of the object or of an individual point within the resolution depth of the transmitting lens with high transversal resolution. The total image of a three-dimensional object is then reconstructed by summing up individual layer images with assigned weight coefficients. A layer-by-layer scanning of a three-dimensional object can be implemented, for instance, using the method pointed to in (Pat. FRG 1762, 406, 2301800, 26555257).
For instance, three-dimensional information is reconstructed in several spatial zones arranged stepwise into 3D space. The zones are then displayed sequentially one after another for a short interval on the controlling video device. Therefore, the observer is offered not only the general view of an object observed in a single plane of image – as we have in cinema or television – but also information on spatial depth which is used as additional information by quantizing over depth. It is expedient to choose the time sequence of the displayed two-dimensional flat images in such a way that the observer (owing to the inertia of eye vision) perceives the sequence as one total image.
In a continuous process of creating a large number of images with various positions of layers, an object is created and poorly defined details are suppressed by filtering through a filter with predominantly high-frequency characteristics. By adding up these filtered signals, the total image of a three-dimensional object is created and the corresponding non-filtered image is added to the filtered one. Filtration here can be implemented with a filter with a linearly growing frequency curve – because it is assumed that in continuous focusing and summation (integration). For instance, if a distribution of intensity of light dots over black background is processed and then this image is integrated, a pointlike image with a wide halo appears.
A change in the focal distance of the quasi-optical system that uses diffractive elements is implemented by changing the frequency of radiation emitted by the irradiator. To implement spatial selection of the signal reflection by the object and the signal sent by the irradiator, and for automatic “tracing” of the region of focusing along one of the coordinates, for instance, along the optical axis, it is advisable to use either off-axis diffractive elements or diffractive elements with off-axis position of the focusing region. The former option is preferable for the radio vision because diffractive elements then retain their focusing ability in a wider frequency band than elements with off-axis position of the focal point.
Formation of images using partially coherent radiation
We will consider the problem of suppressing interference fringes in the optical system for formatting the image, with the irradiator being a small-size thermal source of quasi-monochromatic radiation / << 1, where and are the effective frequency and the irradiator’s frequency band, respectively.
where λ¯= c/ν¯ is the effective wavelength, с is the velocity of light and a is the size of the source (Kaliteevskii N. I., 1971).
If a thermal source of quasi-harmonic radiation is used as irradiator, the interference fringes on the image is removed if the ratio of numerical apertures of the source and the receiver s/0 >> 1 and the resulting resolution corresponds to the diffraction limit of receiver optics with non-coherent illumination.
When an object with specularly reflecting surface is observed, its image contains sparkling that suppresses the fine structure of the image. At the same time sparkling from external sources are superimposed onto the original images.
It is possible to remove this distorting noise without changes in illuminating sources, for instance, by placing in front of a flat object a nonuniform transparent scattering (refracting) plate. The possibility of removing the sparkling is determined by the scattering diagram of the plate and by the optical power of noise.
The illumination of the object in systems of direct vision in the ultrasound band is done with coherent radiation. The image of the object is constructed in reflected radiation using special high-aperture objectives (lenses). An interference image is formed when layer images are added up. Furthermore, most objects have specular surface in this wavelength band. This occurs because the wavelength 0 at which vision systems work is much longer than the visible light wavelength c used to visualize an object 0/c 104. Therefore the surface structure of visualized objects is smoother (more specular) with respect to ultrasonic than it is for light by a factor of (0/c); hence, an interpretation of the resulting image becomes ambiguous. For instance, the image of a sphere is a point.
As it well known reflection coefficients of objects for ultrasound waves are generally random complex value. Hence the conventional coherent imaging systems have suffered to some extent from speckle noise. Speckle occurs when scattered radiation from objects or rough surfaces randomly destructively interferes and degrades image smoothness. So speckle noise and weak edges make the image difficult to identify the object in the ultrasound image. And the analysis of ultrasound image is more challenging one. But if we can generate at each point on the object sufficient large number of sample wave fields with the same magnitude and random phases and the image of the average intensity of the field can be derived, then a desired imaging which is free from speckle noises must be realized (Takayoshi Yokota, Takuso Sato, and Makoto Hirama, 1985).
The “spaced-apart reception” techniques can be used to suppress interference noise in ultrasonic images.
Let us consider an object model consisting of two pointlike reflectors. With two-frequency illumination, the best suppression of interference noise is achieved if
Δλ/λ~1/2m,E4
where m = d/ and d is the distance between the reflectors.
In the case where there is only one wavelength and we have two receivers whose signals are added up, the following condition can be obtained for the angular separation between two receivers:
Ω= arctan[(4m − 1)1/2/(2m − 1)].E5
Similarly, we can derive for n-frequencies illumination and a string of n receivers the formulas
Δλ/λ=(n− 1)/mn,E6
Ωк=arctan[(2mnк−к2)/(mn−к)],n= 2,...,E7
к=0,...,(n − 1).E8
The interval corresponds to the difference between the maximum and the minimum of wavelengths of n-frequencies irradiation and к corresponds to the angular separation between the first and the Kth receiver of the linear string.
Consider the placement of several receivers optimized for suppressing interference noise in a finite field of view.
To suppress interference noise in a finite field of view we distribute n receivers in such a way that for each point there would be two receivers whose signals are in antiphase. We define the number of receivers as the ratio of the solid angle covering the system of receivers to the solid angle of a single receiver.
In order to maximally suppress interference effects at a point A on the axis (fig. 1) it is necessary to place the second receiver 2 at a distance given by formula (1). To suppress interference effects at the edge of the field of view at points BB’ it is necessary to install receivers 3 and 4 at such a distance from receiver 1 that the difference between the optical path lengths between receivers 3 and 4 and the point B equal 1/2 of the wavelength of the radiation used.
Figure 1.
Locations of radiation receivers for suppressing interference noise in a finite field of view.
Consequently, in a string of four receivers, two pairs of them are strictly in antiphase (at the centre and at the edge of the field of view). For n receivers, the number of such locations is n-1. We were looking so far at a one-dimensional case. To consider a two-dimensional case, the string of receivers has to be rotated K times around the X axis by an angle , so that (К)=.
The required number of receivers can be found as
N =Ω/ΔΩ={2π(1 – cosq/2)}/{(π/4)(D/4)2}.E9
Let us find the optimum location of two receivers for an arbitrary location of the object in the field of view. Let the object lie on the axis of the first receiver. The signals of the two receivers will be at opposite phases if
d(r0+d)(r0+d)2+a2−d(r0+d)(r0+d)2+(a+y0)2=λ2.E10
We conclude that for optimum suppression of interference noise the distance between the receivers must equal
y0=[r2d2(rdr2+a2−λ2)−r2]0.5−a,r=r0+d.E11
Therefore, this method of forming radio images on the basis of an “isotropic” receiver (source) essentially consists in implementing the principle of spatial averaging. For instance, the object may be scanned by a focused beam of electromagnetic waves, the radiation scattered by the object being received by a systems of receivers located in space on the side of the irradiator, while the signals from them are added up non-coherently and are sent to the common system of reconstruction. The receivers are placed on the surface of a hemisphere whose centre lies on the object. As a result, it becomes possible to visualize objects using the difference between their reflection coefficient and the reflection coefficient for the background signal, that is, to visualize an image of a three-dimensional object. Non-coherent adding suppresses interference effects. When integrating narrow directed signals reflected from obstacles (the background signal), the received interference signal is proportional to the coefficient of reflection from the obstacle, and this is typically much lower than the coefficient of reflection from the object. On the whole, a system of N receivers proves to be more sensitive than a single receiver by a factor of N1/2. Furthermore, averaging considerably reduces the dynamic range of signals recorded, which makes the requirements to systems reconstructing radio images less stringent.
Another important factor must be mentioned. In systems of direct vision, a receiving device is as a rule large and heavy which makes using this technique very difficult (for instance, the diameter of the objective is at least 200-300, so that even with a speed of 1 frame per second and the number of added layers n 30, the objective that does mechanical scanning of the object over its depth must periodically move at a typical speed of about 350 m/s).
Attempts to use the conventional “optical” approach to constructing ultrasonic images of three-dimensional objects result in extremely unwieldy formulas. The resulting dimensions, weight and parameters of objective lenses fail to satisfy today’s requirements.
Layer-by-layer construction of the image of a three-dimensional object without mechanical scanning over depth can be implemented by using the frequency characteristics of DOE in which the position of focusing area depends on the wavelength of the irradiating field. In this case the speed of the vision system improves considerably. It becomes possible to start with locating an object by scanning over the depth of the scene and then to carefully “scrutinize it” in detail.
Listed below are the main specifics of designing the ultrasonic vision system.
Row-by-row scanning for building the image of an object in real time is carried out by electronic scanning of the string of receivers.
Frame-by-frame scanning (column-by-column scanning) is implemented by mechanically moving the object controlled.
Mirror flashes in the image are removed and the images of the object in different orientations are obtained using quasi-isotropic illumination by a system of irradiators distributed in space.
Scanning of the controlled space is done by the electronically shifting the plane of focusing of the vision device (its focal length) by varying the irradiators’ wavelength and using diffractive optics. The use of elements of diffractive optics on a non-flat surface makes it possible to extend the field of view of the vision device and improve the signal-to-noise ratio in the ultrasonic image.
Access to the object scanned is provided on one side only.
The vision set supports scrutinizing an object with a single frequency (scanning of a plane) or with a number of frequencies (scanning over the depth of the scene) in single-pass or continuous modes of recording the frames of image with an external coupling (to the motion sensor) or internal coupling to the motion of the object, and can also operate in adjustment mode to fine-tune individual components of the vision set.
to be multicomponent (to satisfy the requirements to field of view (2 60°) and the number of resolved pixels on it (N2~100100));
to possess frequency characteristics adequate for inspecting three-dimensional scenes in real time;
to have aperture ratio of at least 0.5 and lens aperture (D/) of at least 200 to provide high spatial resolution constrained by the diffraction limit over the entire field of view;
to be fabricated of a material possessing low absorption of ultrasonic power, and be of minimal thickness.
In the active vision mode, when monochromatic radiation is used to illuminate the target object, it is possible to reshape the focusing surface by controlling the frequency of the illuminating radiation and scan the space over the depth of the scene by this surface (Minin I. V., Minin O. V., et al.1985). Therefore, frequency characteristics of diffractive objectives make it possible to remove limitations stemming from the small depth of definition of classical lenses. Such systems of image generation are capable of scanning space over depths exceeding the depth of definition by a factor of 10 to 20 without mechanical scanners (Minin I. V., Minin O. V. 1986. Baibulatov F. H., Minin I. V., Minin O. V. 1985.). Small thickness of diffractive objectives (on the order of radiation wavelength) allows designers to achieve high efficiency of using ultrasonic power.
Figure 2.
The pilot version (1988) of 40 KHz real-time ultrasonic imaging system for concealed weapon detection, based on points 1,2,5 and developed under the scientific leadership of Professor V. F. Minin (Minin I.V., Minin O.V., 2003).
2. Fresnel lenses design by acoustic network
Fresnel zone plate (amplitude binary type) was designed by Shu Zhang (Shu Zhang., 2010) to pass only the odd (even) zones and obstructs the even (odd) zones. Fig.3 (left) shows the configuration of planar 1D Fresnel lens we designed. The lens is composed of an array of Helmholtz resonators. The resonators which resonate at 50 KHz in pass even zone are filled with water. The cells in odd zone are filled with air to induce large impedance mismatch, resulting large reflection to obstruct vibration.
Finite-element method was employed to study the focusing of the designed Fresnel plate lens. A collimated acoustic wave is incident on the plate, which is put inside water medium. More than 50dB pressure level difference is found between pass and obstruct zones in Fresnel zone plate based on acoustic network at 50 KHz. Compared with conventional Fresnel lens with the same thickness, the focus effect is more efficient through those based on acoustic network design.The focal length of the lens can be tuned at different frequency as well.
Figure 3.
Configuration of acoustic Fresnel lens (left) and the unit of Helmholtz resonator (right) (Shu Zhang., 2010)
3. Elementary principles of diffractive optics design in acoustics
Acoustic zone plates are used to demonstrate various physical processes (Kirilov V. A., Tverdohlebov V. I., Homenko V. I., 1964). Considerable difficulties are encountered, however, in creating acoustic zone plates that invert the phase of oscillations of one half of the zones. The reason is that the acoustic resistance u of any material is so high compared to the resistance of air that acoustic waves are nearly completely reflected. A phase zone plate can be produced using the method suggested by Kock (Kock W. 1965) for fabrication of microwave lenses. The method consists in forcing waves to move between tilted plates; the path length then increases by a factor of 1/cosQ which corresponds to the effective index of reflection n = 1/cosQ for the propagation of waves in free space.
The strip width l is found from the conventional relation d(n - 1) = /2 or d(n - 1) = , which in this particular case of n = 1/cosQ and strip width l = d/cosQ takes the simplest and physically transparent form:
l–d=λ/2 .E12
Also the circular Fresnel zone transducers may be made, for example, of sandwiched structure with C-axis oriented ZnO piezoelectric film between two Au electrodes (QIAO DongHai, LI ShunZhou, WANG ChengHao. 2007).
3. Ultrasonic piezoelectric transducer based on diffractive optics
For active focusing systems the surface of a rigid plate makes bending oscillations, and allocation of their amplitudes of particle displacements along radius of a plate looks like standing waves. Each point oscillations surfaces radiate an ultrasonic wave in an air medium. As is well know, in condition of central exciting of thin flat disk, which radius is multiple to half of flexural waves (in disk material), distribution of oscillating displacement on the disk surface will look like stationary waves. The radial boundaries on the plate from centre of a plate calculating according to the formula from microwaves (Minin O.V., Minin I.V. 2003). In this case the waves radiated of each exact plate will come to a focal point in one phase. The Noise level in a focal point in that case reaches values 200-220 decibel and above, and around of focal point surfaces of equal phases where the noise level reaches values 140-170 decibel is formed. The vibration amplitude of a radiating surface is about 200 micron.
Figure 4.
The active ultrasonic diffractive transducers of half-wave (left) and four-level (right) types.
It could be noted that the advantages of diffractive plate-type emitters are: the possibility of forming ultrasonic vibrations of high power and provide frequency tuning of the radiation due to transition from one harmonic to another. The same diffractive plate-type emitter can create vibrations of different frequencies, operating at different harmonics.
For example, for the circular membrane in an common case we can use polar co-ordinates (r,θ). The spatial part of the wave function will be of the form R(r)Θ(θ). The boundary conditions will act specifically on R(r) which will be a Bessel function Jm(kr) with zeros at well known (tabulated) values xmn (m for the function and n for the nth zero). This leads to the relation kmna=xmn to force a zero at r=a, the radius of the membrane. These results in the following relation for computing the angular frequency associated with the different modes:
ωmn=xmnva,E13
where v is the velocity of the wave in the membrane. The solution of our problem for the mode (m,n) is, basically, of the form:
S(r,θ,t)=Jm(kmnr)cos(mθ)cos(ωmnt)E14
.
A dependence with sin(mθ) is also possible, giving rise to the existence of 2 degenerate modes for each m (except for m=0). In general, a linear combination of both modes will be excited.
For the case of a transducer we need only the modes with m=0. The distribution of oscillations amplitude on the first three oscillation modes of disk radiator is shown in Fig 5.
Figure 5.
The distribution of oscillation amplitude of diffractive radiator on the different oscillation modes: n=1, 2, 3.
4. Some other diffractive optical elements applications in acoustics
If used as focusing emitter, the acoustic converter is fabricated as a zone plate. For instance, a binary zone plate with 10 zones made as a sequence of gold electrodes on the surface of a ceramic converter was described in (Stamnes J. J., Cravelsxter J., 1982). The other side of the converter has a common metal coating. When used to transform electric fields, only transparent zones emit. This means that the same zone plate can be used to generate both an “audio” picture and an image of an object.
Acoustically emitted diffractive focusing elements possess another very interesting and very promising property (Kock W., 1965. Greguss P., 1980). If zones made of gold electrodes are replaced with photoconducting layers and placed between a converter and an optically transparent electrode, this device can be controlled by light. If an optical image of a diffractive element is projected onto such a converter and is moved transversally, the point of acoustical focus will also move. Therefore, two-dimensional scanning can be realized.
The design and development of a low cost, electro-mechanical ultrasonic scanner for obtaining high resolution C-scan images of the friction skin ridge structure found on the digits of the hands or feet in order to create imagery of sufficient quality for use in automated personal identification systems were discussed in (J.K. Schneider, S.M. Gojevic. 2001). It has been shown the optical scanner is unable to image through the contamination, while the ultrasonic scanner is unaffected.
A breadboard ultrasound sensor has been developed for remotely detecting and imaging concealed weapons (Applied Technologies - Jaycor http://www.jaycor.com/eme_sens_ ultra.htm). The breadboard sensor can detect metallic and non-metallic weapons concealed on a human body under heavy clothing at ranges up to 8 m and can image concealed weapons at ranges up to 5 m.
This breadboard sensor has produced the only remote ultrasound images of concealed weapons, including lexan (plastic) knives and a handgun concealed under a heavy sweatshirt at 15 feet. The sensor includes a highly efficient source of high-power, tunable ultrasound radiation suitable for remote imaging in air. Together with millimeter-sized, highly sensitive ultrasound detectors and high-gain transceivers, these advances make possible the centimeter-resolution imaging of concealed weapons at ranges between 1 m and 5 m.
Ultrasound is also a “technology that uses high-pitched sound waves to create images of hidden internal anatomy” to detect a land-mine (C. P. Gooneratne, S. C. Mukhopahyay, G. Sen Gupta. 2004). Conventional ultrasound detection involves the emission of a sound wave with a frequency higher than 20 kHz into a medium. This sound wave reflects on boundaries between materials with different acoustical properties. A strong enough ultrasound signal could penetrate the ground and detect otherwise unobtainable signatures of buried mines. It is also capable of operating in wet ground. Ultrasound systems encounter problems at the interface of air and ground.
One of the classical applications of the ultrasonic imaging system is a nondestructive method of inspection. For example (SERDP PP-1134, Final Report, November 2001), the inspection of very thin metallic sheets (0.06 inches up to 0.125 inches thick) was shown to be difficult for the reflection method of ultrasound imaging to undertake; this was due to the extremely short time delay between the front and back surfaces of the thin sheets. By injecting the sound beam into the metallic sheet at an appreciable angle it was found to cause multiple reflections progressing along the sheet with the end result of illuminating a large region of the sample with sound energy. A prototype angle beam ultrasound camera was fabricated at the Becker Labs of the Naval Air Warfare Center Aircraft Division (Figure 6) and has proven that rapid ultrasound imaging of thin sheet is practicable and is unaffected by painted coatings.
Figure 6.
Schematic of oblique angle reflection camera for real-time ultrasound imaging (SERDP PP-1134, Final Report, November 2001).
The Acoustocam system (Development of Innovative Nondestructive Evaluation Technologies for the Inspection of Cracking & Corrosion Under Coatings SERDP PP-1134, Final Report, November 2001) was shown to be able to respond to the dynamic range of the multiple bounces with an image very similar to that of a through transmission image with the exception that recurring images of a defect are observed in the oblique angle reflection mode owing to the fact that the sound beam continues to reflect (See Figure 7). The concept, however, has proven to be viable for the inspection of corrosion under painted coatings at high speed and with high sensitivity. Application has been made for the issuance of a patent based on the oblique angle beam system.
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I.Generation of radio images by phase inversion zone plates // Radiotehnika i elektronika. 1975202405406\n\t\t\t'},{id:"B4",body:'MininI. V.MininO. V.Diffractive-MoscowOptics.InformN. P. O.T. E. I.1992p. (in Russian)'},{id:"B5",body:'MininI. V.MininO. V.Information properties of zone plates // Computer optics, 198831522'},{id:"B6",body:'MininI. V.MininO. V.Diffractive radio optics systems: achievements and prospects: Abstracts of the USSR conference "Optical, radiowave and thermal methods of nondestructive monitoring". Mogilev, 1989204205'},{id:"B7",body:'PatF. R. G.1764'},{id:"B8",body:'PerinaJ.Coherence of. light Van Nostrand. London1972Tarlykov V. A., Magurin V. G. Foundations of Coherent and Statistical Optics / Sankt-Peterburg, SPbGITMO, 2002 (in Russian)'},{id:"B9",body:'KaliteevskiiN. I.Waveoptics. M.Nauka1971in Russian)'},{id:"B10",body:'MininI. V.MininO. V.Generation of radio images of 3D objects in the mm wavelength range // In: Proceedings of NVOKU, Novosibirsk, 199844046'},{id:"B11",body:'Takayoshi Yokota, Takuso Sato, and Makoto Hirama.Active incoherent ultrasonic imaging through an inhomogeneous layer J. Acoust. Soc. Am. 771144152January 1985\n\t\t\t'},{id:"B12",body:'MininI. V.MininO. V.Radiovision methods in terrorism struggle.- Novosibirsk, NSTU, 2003p. (in Russian)'},{id:"B13",body:'MininI. V.MininO. V.Wide-angle multicomponent diffractive microwave lens // Radiotehnika i elektronika.-1986314800806'},{id:"B14",body:'Edward O.Belcher et al.1999Beamforming and imaging with acoustic lenses in small, high-frequency sonars.- The Proc. Of Oceans’99 conf., 1316Sept. Seattle WA, preprint,'},{id:"B15",body:'Yuji Sato at al.2009Design for Aplanatic Fresnel Acoustic Lens for Underwater Imaging. Japanese Journal of Applied Physics 48 (GL04, 17\n\t\t\t'},{id:"B16",body:'MininI. V.MininO. V.SkarboB. A.1985 Application of microwave holographic radio lenses in nondestructive testing and plasma diagnostics. Abstracts of 5th USSR Conf. on Holography. Riga, 233234in Russian)'},{id:"B17",body:'BaibulatovF. H.MininI. V.MininO. V.Focusing properties of Fresnel zone plate // Radiotehnika i elektronika. 198530916811688'},{id:"B18",body:'Shu Zhang. 2010ACOUSTIC METAMATERIAL DESIGN AND APPLICATIONS.Dissertation Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Mechanical Engineering in the Graduate College of the University of Illinois at Urbana-Champaign, '},{id:"B19",body:'KirilovV. A.TverdohlebovV. I.HomenkoV. I.Demonstration experiment with acoustic zone plate // UFN, 1964701166\n\t\t\t'},{id:"B20",body:'Kock W Sound waves and light waves, N.Y., 1965'},{id:"B21",body:'QIAO DongHai, LI ShunZhou, WANG ChengHao.High frequency acoustic microscopy with Fresnel zoom lens, Sci China-Phys Mech Astron. Feb 20075014152'},{id:"B22",body:'MininO. V.MininI. V.Diffractive optics of millimeter waves.- IOP publisher, Boston-London, 2003'},{id:"B23",body:'GregussP.Ultrasonicimaging.FocalPress.LimitedLondon. N.N.Y., 1980'},{id:"B24",body:'StamnesJ. J.CravelsxterJ.BentsenO.Image quality and diffraction efficiency of a holographic lens for sound waves // Acoustical imaging / Ed. by P. Alais, A. F. Tetherell. N.Y.: Plenum Press, 198210587606'},{id:"B25",body:'ErmolaevI. N.KanevskiiI. N.KofolevV. D.et al Focusing zoned finder for ultrasound non-destructive testing // Defektoskopiya. 198019496'},{id:"B26",body:'ChernoverskiiM. P.Focusing zoned converter with low electric capacitance // Defektoskopiya. 1988294\n\t\t\t'},{id:"B27",body:'SchneiderJ. K.GojevicS. M.Ultrasonic Imaging Systems for Personal Identification. Proc. Of the Ultrasonics Symposium, 2001IEEE, 1595601'},{id:"B28",body:'Ultrasound Sensor for Remote Imaging: Concealed Weapons http://www.jaycor.com/eme_sens_ultra.htm'},{id:"B29",body:'GooneratneC. P.MukhopahyayS. C.SenG.GuptaA.Reviewof.SensingTechnologies.forLandmine.DetectionUnmanned.VehicleBased.ApproachProc. 2nd International Conference on Autonomous Robots and Agents, December 13-15, 2004Palmerston North, New Zealand, 401407\n\t\t\t'},{id:"B30",body:'Development of Innovative Nondestructive Evaluation Technologies for the Inspection of Cracking & Corrosion Under Coatings2001 SERDP PP-1134, Final Report, November '}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"I.V. Minin",address:"",affiliation:'
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1. Introduction
The consumer’s interest in a healthier lifestyle has led to the development of foods that meet nutritional and health needs and that at the same time are attractive, tasty, and with good acceptance in the market. Products that support positive health effects or ingredients with these characteristics, claimed or proven, are called “emitted foods” [1].
The relationship between food and health is one of the keys to disease prevention and well-being promotion. As a result, industries have started to enrich foods with specific ingredients, differentiating them about the benefits offered to health compared to foods in their traditional forms [2, 3, 4].
In the present century, the scientific literature reports functional foods as allies in the treatment of obesity [5], prevention of cardiovascular diseases [1], plasma cholesterol balance [6], and cancer prevention [7]. Among functional foods, the literature reports prebiotics (added with non-digestible fibers), fortified (with vitamins, omega-3), altered (removing harmful components), and probiotics [8].
According to Resolution No. 19, of April 30, 1999, on the claim of functional property of food, it is that related to the metabolic or physiological role that the nutrient or non-nutrient has in the growth, development, maintenance, and other normal functions of the human organism [9]. Among the functional compounds most investigated by science, we have probiotics, which according to RDC n° 241, of July 26, 2018, are defined as live microorganisms that confer benefits to the individual’s health [10, 11].
The word probiotic has a Greek derivation in which it means “for the sake of life”, that term was first introduced by Lilly; Stillwel in 1965 to describe substances secreted by a microorganism, which stimulates the growth of another [12, 13, 14]. Fuller (1989) defined probiotics as a supplement composed of live microorganisms that benefit the host’s health through the balance of the intestinal microbiota. The term probiotic can be complemented as a pure culture or composed of living microorganisms that supplied to man or animals benefit the host by stimulating the properties existing in the natural microbiota [15].
Probiotics, after ingested, must be able to survive the stress conditions present in the gastrointestinal tract, such as gastric juice, the presence of bile salts, and digestive enzymes, and maintain their viability and metabolic activity in the intestine to exert beneficial effects on the hosts. As for the technological challenges for the industrial production of cells, they must remain stable and viable at satisfactory levels throughout the product’s validity period [16, 17, 18]. Based on this assumption, there is a recent and growing scientific interest in improving the stability, bioavailability, and shelf life of products with probiotic sources using nanotechnology as an enhancement technique, since nanostructured systems may be able to control stability, improve solubility, bioavailability, and controlling the release of bioactive compounds [19, 20, 21].
The reduction of materials to the nanoscale leads to new and exciting properties and the increase of the surface volume ratio, increasing its reactivity. This characteristic of nanoparticles has attracted commercial interest in the manufacture of nano-ingredients, supplements, and nutraceuticals. Several types of nanoparticles can be found in the literature, such as metallic, semiconductor, carbon-based, metallic, and polymeric oxides, which can be applied in various sectors, predominantly personal care, health care, and cosmetics. The benefits of nanotechnology in the food sector go through the entire food chain, starting from production to processing, transportation, security, storage, and delivery [22, 23]. Based on the above, we will cover in this chapter a review on the use of natural probiotics and nanomaterials, aiming to specify their advantages and methodologies of preparation and characterization.
2. Natural probiotics
Probiotics can be defined as food supplements that contain live microorganisms or microbial components that, when ingested in a certain number, have a beneficial effect on the health and well-being of the host [17].
Among these benefits include antimicrobial activity; control of pathogenic microorganisms [24]; lactose hydrolysis; modulation of constipation; antimutagenic and anticarcinogenic activity [25, 26]; reduction of blood cholesterol, improvement of patients with type 2 diabetes (insulin resistance) and obesity [27, 28, 29]; modulation of the immune system; improvement in inflammatory bowel disease; and suppression of Helicobacter pylori infection [30, 31, 32]. Some of these benefits are already well established, such as constipation and lactose hydrolysis modulation, while other benefits have shown promising results in animal models, requiring further clinical studies [33].
Probiotics can be incorporated into a wide variety of food products, mainly in dairy products, such as milk, ice cream, yogurt, and cheese. Its application has also grown in other types of foods, such as soy milk, mayonnaise, pates, meats, baby food, confectionery, sweets, cakes, and chewing gum [34, 35, 36, 37].
The selection of probiotic bacteria is based on the following criteria: gender, origin (which must be human), stability against stomach acid and bile salts, the ability to adhere to the intestinal mucosa, the ability to colonize, at least temporarily, the human gastrointestinal tract, the ability to produce antimicrobial compounds and metabolic activity in the intestine [38, 39, 40].
In order for the microorganism to be able to promote the aforementioned beneficial effects, a minimum intake of 108–109 colony-forming units (UFC) per day is recommended [41]. In addition, the minimum concentration of live bacteria should not be less than 10 CFU/g of food since many cells die during passage through the gastrointestinal tract (TGI) [1, 42].
2.1 Types of probiotics
Specific probiotic strains give the benefits transmitted to health, and not by specific species or genus. However, that each strain is related to a specific benefit. In this way, no strain will provide all of the proposed benefits. For example, Lactobacillus casei lineage Shirota, in which evidence supports the view that its oral administration can assist in the digestion and absorption of nutrients and restore the normal balance of the intestinal microbiota [43]. Other relevant factors are the addition of mixtures of probiotic cultures instead of individual strains [44] and the number of viable cells of these microorganisms in the marketed product.
In a healthy adult intestine, the predominant microbiota is composed of health-promoting microorganisms (Table 1), mostly belonging to the genera Lactobacillus and Bifidobacterium [45]. Other lactic acid bacteria with probiotic properties are: Ent. faecalis, Ent. faecium, and Sporolactobacillus inulinus, while the microorganisms Bacillus cereus, Escherichia coli Nissle, Propionibacterium freudenreichii, and Saccharomyces cerevisiae have been cited as non-lactic microorganisms associated with probiotic activities mainly for pharmaceutical or animal use [32, 33, 46].
Main microorganisms used for their probiotic properties, in the form of drugs or added to foods.
Strains that have been used in the prevention and treatment of allergic diseases [45].
Some individuals may experience little of the side effects related to the ingestion of probiotics due to the death of pathogens in the intestinal environment since they release toxic cellular products, a reaction called a “die-off reaction”. In such cases, the use of probiotics should be persisted in order to improve symptoms. There is a slight increase in gas production, abdominal discomfort, and even diarrhea, which resolves over time [12].
2.2 Mechanism of action
Three possible mechanisms of action are attributed to probiotics: the suppression of the number of viable cells through the production of compounds with antimicrobial activity, competition for nutrients, and competition for adhesion sites. The second of these mechanisms would be the alteration of microbial metabolism by increasing or decreasing enzyme activity. The third would be to stimulate the host’s immunity by increasing the levels of antibodies and increasing the activity of macrophages. The spectrum of activity of probiotics can be divided into nutritional, physiological, and antimicrobial effects [47, 48]. The direct modulation of the immune system may be secondary to the induction of anti-inflammatory cytokines or by the increase in the production of secretory IgA [45].
Despite the scientific evidence regarding the mechanisms of action of probiotics, there is still a lack in the literature on biochemical and molecular pathways that fully explain these effects, such as, for example, increasing the function of the intestinal barrier. Despite the scientific evidence regarding the mechanisms of action of probiotics, there is still a lack in the literature on biochemical and molecular pathways that fully explain these effects, such as, for example, increasing the function of the intestinal barrier [49].
Currently, the mechanisms of action of probiotics for anticarcinogenic effects have been studied. These are believed to occur through (1) inhibition of bacteria responsible for converting pre-carcinogenic substances (such as polycyclic aromatic hydrocarbons and nitrosamines) into carcinogens; (2) direct inhibition in the formation of tumor cells; and (3) the ability to bind and/or inactivate carcinogenic substances [25]. Several mechanisms of action have been suggested, including the stimulation of the host’s immune response (by increasing phagocytic activity, IgA synthesis, and the activation of T and B lymphocytes), the binding and degradation of compounds with carcinogenic potential, qualitative changes and/or quantitative in the intestinal microbiota involved in the production of carcinogens and promoters (ex: bile acid degradation), production of antitumor or antimutagenic compounds in the colon (such as butyrate), alteration of the metabolic activity of the intestinal microbiota, alteration of the physical- colon chemicals with decreased pH and effects on host physiology [33, 50].
The use of probiotics represents a promising and rapidly growing area for the development of functional foods. Probiotic cultures are successfully applied to different food matrices. However, the development of non-dairy products represents a challenge for the industry, as each food matrix has unique characteristics, and it is necessary to optimize and standardize each type of product [51].
In this context, nanomaterials have been widely studied as a technique to improve the stability of these microorganisms and functional foods, protecting them from unfavorable environments, improving the uptake, absorption, and bioavailability of nutrients for the body (Table 2) [19].
Documented effects on humans and/or animals
Possible immunomodulation mechanism
Local effects
Mucous barrier
Maintenance and repair of the intestinal barrier and intercellular junctions
Reduced permeability and decreased systemic absorption of allergens/antigens
Enterocytes
Increased production of TGF-β and prostaglandin E2 responsible for promoting tolerance of antigen-presenting cells
Reduction of local inflammation and promotion of tolerance
Receivers enterocytes (toll-like)
Anti-inflammatory effects of probiotics mediated by toll-like receptors 9
Inhibition of allergic responses, type Th2: mechanism not yet clarified
Cells presenting antigens (dendritic cells)
Increased activity of dendritic cells in the intestine
Promotion of tolerogenic effect by dendritic cells
Auxiliary (or effector) T cells
Increased Th1-type response
Inhibition of Th2 response differentiation
Regulatory T cells
Production of Il-10 and TGF-β associated with oral tolerance. Increased TGF-β (Th3)
TGF-β produced locally (including by enterocytes) promotes tolerogenic effect by dendritic cells, local IgA, and increased Treg activity
B cells and antibodies
Colonization: enlarged lymphoid tissue
Promotion of a tolerogenic environment
Systemic effects
T cells
Increased Th1 differentiation
Secondary to the effects of T cells in the gastrointestinal tract
B/IGA cells
Increased production of IgA in other tissues (respiratory tract)
Secondary to the effects of B cells in the tract gastrointestinal
Table 2.
Immune mechanisms of action associated with probiotics.
Technological advances aimed at developing imaging equipment and techniques for characterization make it possible to develop and characterize systems on a nanoscale through scanning electron microscopy and transmission electron microscopy. Nanotechnology in the food area is designed to encapsulate, carry, and release bioactive ingredients to incorporate and modify the food structure. In addition, they make it possible to study the structures in detail, make it possible to understand their properties and facilitate their handling to obtain new, high-quality and safe foods [52].
Nanotechnology involves the characterization, fabrication and/or manipulation of structures, devices, or materials that have at least a dimension of about 1–100 nm in length [53, 54] and has emerged as one of the most promising scientific areas of research. Numerous companies are currently specialized in the manufacture of new forms of materials (nanometric size) with typical applications in medical therapy, diagnostics, energy production, molecular computing, and structural materials [55]. This technology in food introduces new opportunities for innovation in the food industry with immense speed. Thus, some of the applications result in the presence of nanoparticles or nanostructured materials in the food. This innovation can be applied to the macroscale characteristics of foods, such as texture, taste, other sensory attributes, color intensity, processability, and stability during shelf life, leading to many new products. In addition, nanoencapsulation technology can also improve water solubility, thermal stability, and oral bioavailability of bioactive compounds [14, 56].
One of the biggest focuses of nanotechnology in the food industry is encapsulation systems and the controlled release of nutrients. The use of nanomaterials has shown improved properties for the encapsulation of probiotics. Due to their unique physical and chemical properties, nanostructured encapsulating materials show great promise of protecting microorganisms from acidic stomach conditions, increasing absorption and, therefore, allowing the successful release of probiotic cells trapped in the intestinal lumen with natural pH [57, 58].
The clinical efficacy of oral administration of probiotic bacteria is still diminished due to loss of viability during the gastrointestinal passage, resulting in poor intestinal distribution. Microencapsulation technology using nanomaterials is a successful strategy to solve this problem, maintaining the viability of probiotics, thus improving their effectiveness after oral administration [58]. In recent years, the production of probiotic and functional foods using nanotechnology represents one of the main current challenges [59].
The most basic nanomaterials used are nanoparticles. These can be presented in different forms, such as spherical nanoparticles (three nanometric dimensions); nanotubes and nanofibers (elongated structures with two dimensions on a nanoscale), and nanoplates (only have the nanometric thickness). Several examples of nanoparticles are cited in the literature, such as nano-clay, silver (Ag), titanium dioxide (TiO2), and zinc oxide (ZnO) nanoparticles [22].
Different types of nanoformulations can be used, which requires the adequate formulation and timely processing conditions. Among them, polymeric nanoparticles, nanocomposites, solid lipid nanoparticles (NLS), liposomes, and nanoemulsions are suitable for food applications [57, 60].
3.1 Types of systems for encapsulation of bioactive compounds
Nanoparticles (NPs) and nanostructured materials (NSMs) represent an active area of research with application in several domains. They are exciting nanoscale systems due to the ease with which they can be produced in different ways. NPs and NSMs arouse interest due to their adjustable physicochemical characteristics, such as melting point, wettability, electrical and thermal conductivity, catalytic activity, light absorption, and dispersion, resulting in improved performance compared to their mass counterparts [61]. NPs and nanosystems are broadly divided into several categories, depending on their morphology, size, and chemical properties [62]. Currently, some of the most studied nanostructured delivery systems are nanoemulsions, nanoliposomes, nanohydrogels, lipid nanoparticles, and coacervates with application in food (Figure 1) [63].
Figure 1.
Types of nanoparticles. Inorganic nanoparticles, polymeric nanoparticles, solid lipid nanoparticles, nanosomes, nanocrystals or quantum dots, carbon nanotubes, and dendrimers.
3.1.1 Polymeric nanoparticles
Polymeric nanoparticles are formed by a polymeric matrix (nanospheres) or a reservoir system in which the main content is hydrophobic or oily surrounded by a polymeric wall (nanocapsule) [64]. They are among the delivery systems for bioactive compounds most accepted and approved by GRAS [65]. In addition, they gained considerable attention in nanomedicine due to the potential for surface modification, pharmacokinetic control, suitability for targeted delivery of therapies [66], mechanical properties [67], and design flexibility. More specifically, size, surface morphology, chemistry and charge, porosity and diffusivity of the drug, and encapsulation efficiency are properties that push polymeric nanoparticles to the forefront of nanomedicine applications [68] and may behave similarly when incorporated into food.
The chemical and biocompatibility properties of polymeric nanoparticles have been studied extensively in recent years and allow these nanometric delivery systems formed by natural or synthetic polymers to be helpful in the controlled release of natural bioactive compounds, hormones, genes, and anticancer drugs with greater effectiveness than micrometric systems such as microparticles [69]. Due to a high surface contact area occur an intense interaction between the matrix in which they are inserted and the nanoparticles [70].
Currently, the most used polymers for the formation of the nanometric system are poly (lactic acid) (PLA), poly (glycolic acid) (PGA), poly (lactic-co-glycolic acid) - (PLGA), and polycaprolactone (PCL). Nanoparticles and microparticles can be obtained through different techniques that can be classified into four categories. Category 1: a traditional method based on the formation of an emulsion consisting of single emulsion, double emulsion, and multiple emulsions, followed by evaporation of the solvent. Category 2: methods based on nanoprecipitation, the rapid expansion of supercritical fluid in liquid, salting, and dialysis. Category 3: direct composition methods, such as fusion technique, spray-drying, supercritical fluid. Category 4: new approaches, including microfluidic and mold/mold-based techniques [65, 69].
The main active substances used for encapsulation by the methods of obtaining nanoparticles are isolated substances. However, some authors, such as Nascimento et al. [71] and Azevedo et al. [65], developed polymeric nanoparticles of Brazilian red propolis extract contributing to the development of nanostructured technologies for natural products.
3.1.2 Nanoliposomes
Nanoliposomes are defined as spherical lipid bilayer vesicles, resemble the lipid bilayer of cell membranes, and maintain nanometric or submicronic bands during storage and applications [72, 73, 74]. Its bilayer structure, formed by one-half of the lipid bilayer, contains a hydrophilic head and a lipophilic acyl chain. Thus, its amphipathic nature allows it to encapsulate hydrophilic and hydrophobic compounds individually or simultaneously due to its bifunctional physicochemical properties and, consequently, it presents interaction with a wide range and variety of molecules [75]. Nanosystems are drug-carrying structures with potential for application in the medical field and food industry. However, they have low robustness regarding physical and thermal stability and pH variations, being considered significant challenges for their intended commercialization [76].
The most common method used for the production of nanoliposomes is to obtain a double emulsion followed by a microfluidization process at room temperature after the previous removal of the solvent. It is possible to produce nanoliposomes using low-cost natural ingredients (for example, soy, egg yolk, sunflower, milk), optimizing the cost-effectiveness of the final product [72]. The literature reports several clinical trials using nanoliposomes, and studies reveal that they are excellent candidates for various distribution systems, such as anticancer, antifungal and antibiotic drugs, administration of genetic drugs, and administration of anesthetics and anti-inflammatory drugs [77]. Similarly, it will have application in the food area, allowing the incorporation and simultaneous release of two or more bioactive compounds with different solubilities, as is the case of medium-chain liposomes and vitamin C, enhancing food functionality [74].
3.1.3 Solid lipid nanoparticles
Lipid nanoparticles are similar to nanoemulsions in which the oil phase was totally or partially solidified [56]. It is a colloidal carrier system that makes it possible to encapsulate, protect and distribute functional lipophilic components, such as bioactive lipids and drugs [70]. The size and structure of the lipid nanoparticles are similar to nanoemulsions, with a size that usually ranges from 50 to 1000 nm. The lipid nucleus in nanoemulsions is liquid, but the lipid nucleus is in a solid-state [78].
Solid lipid nanoparticles can be classified as solid lipid nanoparticles (SLNs) and nanostructured lipid transporters (NLCs). In general, homogenization techniques of cold or hot high pressure and double emulsions are currently being used more to produce SLNs and NLCs to encapsulate bioactive oils [79]. The composition of SLNs is usually lipids such as triglycerides (tristearin), partial glycerides (glyceryl monostearate), fatty acids (stearic acid), sterols (cholesterol), and waxes (cetyl palmitate) [70].
There is a great difficulty associated with lipophilic bioactive agents in food matrices in the food industry, one of the main problems for manufacturers in the development of nutraceutical and functional foods [80]. Thus, SLNs and NLCs aim to assist as a nanoparticle carrier of bioactive compounds with a lipophilic character. SLNs are nanometric lipid matrices between 50 nm and 1 mm in diameter, and these nanostructured systems are capable of effectively encapsulating active, sensitive molecules that must be protected from different environmental conditions, such as light, moisture, and oxidation. In addition, the solid matrix allows a controlled release and a high capacity to reach the target organ [79]. NLCs, whose matrix consists of a mixture of lipids with different physicochemical properties instead of just one type of lipid, were initially synthesized to avoid SLN problems with loading. They can form physical lipid mixtures through the mixture of solid and liquid lipids (oil), but without crystallization, presenting a more unstructured (entropic) matrix that allows the control of the molecular load [74, 79].
3.1.4 Nanohydrogels
Nanohydrogels are defined as an infinite network of hydrophilic three-dimensional polymers swollen by water without losing their interconnected porous structure, expanding, and disintegrating [81, 82, 83]. For application in food, they must be composed of non-toxic, biodegradable, and biocompatible biopolymers to deliver bioactive compounds in / or through the mucosa of the gastrointestinal tract. Nanohydrogels are soft materials widely used by the food and nutraceutical industries [83].
Generally, hydrogels are formed by chemical or physical cross-linking polymers. They are basically formed by three integral parts: monomer, initiator, and crosslinker [84]. Different techniques can be adapted to obtain the nanohydrogels such as mass polymerization, solution, and suspension, taking into account that the impurities, including unreacted monomer, initiators, crosslinkers, and unwanted products generated, need to be removed after their preparation [81].
Nanohydrogels formed by biopolymeric proteins or polysaccharides are the best alternatives for application in food since they can offer improved functional properties compared to native proteins. The size, structure, load, permeability, porosity, and stability to environmental and solution conditions are essential and fundamental characteristics for nanohydrogels and depend in general on the physicochemical properties of the biopolymers chosen to obtain the gel. [85]. The proper adjustment of these variables allows the functional compounds to be loaded and then released from the polymeric matrix [86]. The choice of the type of polymeric matrix must be adequate considering that hydrophilic compounds can be released from a protein matrix by diffusion, while lipophilic compounds are released mainly by enzymatic degradation of the protein matrix in the GI tract [21, 81, 85].
3.1.5 Nanoemulsion
The definition of nanoemulsion consists of an excellent dispersion composed of an oily phase (triglycerides or hydrocarbons) and an aqueous phase (water or water with some electrolyte or polyol), which appears as spherical drops with a diameter less than 100 nm [70]. The nanoemulsion droplets most often have a core of lipophilic material, which one or more non-polar components may form. The surrounding contents of the nucleus are formed by the material of opposite polarity [81].
There is a wide variety of methods for making stable nanoemulsion. The nanoemulsion preparation is divided according to the energy level adopted in the system as the high and low energy method [87]. The main methods used to obtain a nanoemulsion include high-pressure homogenizers and ultrasound generators representing the high energy method, including microfluidization [88]. Low-energy emulsification methods are cost-effective, in which nanoemulsions with tiny droplets are prepared using low amounts of energy, which stand out the methods of spontaneous emulsification, reverse phase technique, membrane emulsification method, and solvent displacement method [89].
Nanoemulsions offer a wide range of applications due to their composition flexibility in several fields, including food, beverage, and pharmaceutical industries for product storage and delivery. Currently, it can be used to encapsulate lipophilic components, such as vitamins, substances that impart flavors, colors, preservatives, nutraceuticals, and medicines. In addition, it can be applied to preserve food and bioactive compounds, increasing bioavailability and shelf life. Another essential application aimed at the food industry is the possibility of masking unpleasant odors and flavors and protecting bioactive molecules from oxidation and hydrolysis by the action of air and water, respectively [89].
4. Conclusion
Nanotechnology is a potential new technology in food, being one of the primary resources for development and innovation. Reducing the particle size of bioactive compounds can improve bioavailability, release control, delivery targeting, and solubility. The choice of the preparation technique for the nanostructured systems depends on the characteristics of the bioactive compound, such as hydrophilic or lipophilic, solubility, stability, and the desired properties for the product, such as particle size and bioavailability, among others. Thus, it is possible to verify some of the nanoencapsulation techniques that can be used in bioactive compounds, and many undesirable characteristics can be circumvented with nanotechnology.
Acknowledgments
This work was supported by grants of CNPq, CAPES, FAPEAL, and FAPEMIG.
Conflict of interest
The authors declare no conflict of interest.
\n',keywords:"natural probiotics, nanomaterials, new functional foods, nutraceutical characteristics, nanobiotecnology",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/78770.pdf",chapterXML:"https://mts.intechopen.com/source/xml/78770.xml",downloadPdfUrl:"/chapter/pdf-download/78770",previewPdfUrl:"/chapter/pdf-preview/78770",totalDownloads:144,totalViews:0,totalCrossrefCites:1,dateSubmitted:"May 27th 2021",dateReviewed:"June 19th 2021",datePrePublished:"September 27th 2021",datePublished:"April 6th 2022",dateFinished:"September 27th 2021",readingETA:"0",abstract:"Natural probiotics are functional foods with several biological properties and nutritional value inherent to their chemical composition and can play a potentially beneficial role in reducing the risk of chronic degenerative diseases. In order to improve the stability of these compounds, increase the encapsulating power, delay oxidation, increase their effectiveness, control their release and improve the bioavailability of their combination with nanomaterials is a potential tool in the food area enabling the development of new products with functional and nutraceutical characteristics. In addition, the study of nanomaterials in natural probiotics is rarely reported in the literature, being an area of paramount importance in the development of new functional foods. Therefore, in this chapter, a review of nanomaterials’ use in natural probiotics will be addressed to specify their advantages and methodologies of preparation and characterization.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/78770",risUrl:"/chapter/ris/78770",signatures:"Ilza Fernanda Barboza Duarte, Naianny Lívia Oliveira Nascimento Mergulhão, Valdemir da Costa Silva, Laisa Carolina Gomes de Bulhões, Irinaldo Diniz Basílio Júnior and Anielle C.A. Silva",book:{id:"10746",type:"book",title:"Prebiotics and Probiotics",subtitle:"From Food to Health",fullTitle:"Prebiotics and Probiotics - From Food to Health",slug:"prebiotics-and-probiotics-from-food-to-health",publishedDate:"April 6th 2022",bookSignature:"Elena Franco Robles",coverURL:"https://cdn.intechopen.com/books/images_new/10746.jpg",licenceType:"CC BY 3.0",editedByType:"Edited by",isbn:"978-1-83969-576-6",printIsbn:"978-1-83969-575-9",pdfIsbn:"978-1-83969-577-3",isAvailableForWebshopOrdering:!0,editors:[{id:"219102",title:"Dr.",name:"Elena",middleName:null,surname:"Franco-Robles",slug:"elena-franco-robles",fullName:"Elena Franco-Robles"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:[{id:"340051",title:"Prof.",name:"Anielle C.A.",middleName:"Almeida",surname:"Silva",fullName:"Anielle C.A. 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Introduction",level:"1"},{id:"sec_2",title:"2. Natural probiotics",level:"1"},{id:"sec_2_2",title:"2.1 Types of probiotics",level:"2"},{id:"sec_3_2",title:"2.2 Mechanism of action",level:"2"},{id:"sec_5",title:"3. Nanomaterials",level:"1"},{id:"sec_5_2",title:"3.1 Types of systems for encapsulation of bioactive compounds",level:"2"},{id:"sec_5_3",title:"3.1.1 Polymeric nanoparticles",level:"3"},{id:"sec_6_3",title:"3.1.2 Nanoliposomes",level:"3"},{id:"sec_7_3",title:"3.1.3 Solid lipid nanoparticles",level:"3"},{id:"sec_8_3",title:"3.1.4 Nanohydrogels",level:"3"},{id:"sec_9_3",title:"3.1.5 Nanoemulsion",level:"3"},{id:"sec_12",title:"4. Conclusion",level:"1"},{id:"sec_13",title:"Acknowledgments",level:"1"},{id:"sec_16",title:"Conflict of interest",level:"1"}],chapterReferences:[{id:"B1",body:'Farias, TGS, Stamford, TCM, Ribeiro, VMS, Ladislau, HFL, Medeiros, JAC, Arnaud, TMS, Stamford, TLM. 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Mint: O papel da nanotecnologia na redução do estresse oxidativo: uma revisão. Boletim Informativo Geum. 2018; 9: 1.'},{id:"B54",body:'Ferreira, AS. In: Ciência E Tecnologia De Alimentos: Conceitos E Aplicações. Eduft. 2019. p. 109-122.'},{id:"B55",body:'Bazana, MT, Codevilla CF, Silva, CB, Menezes, CR. Mint: Nanoencapsulação de licopeno em alimentos. Ciência e Natura. 2015; 37: 38-48.'},{id:"B56",body:'McClements, DJ. Mint: Edible nanoemulsions: fabrication, properties, and functional performance. Soft Matter. 2011; 7: 2297-2316.'},{id:"B57",body:'Martins, VC, Braga, ECO, Godoy, RLO, Borguin, RG, Pacheco, S, Santiago, MCPA, Nascimento, LSM. Mint: Nanotecnologia em alimentos: Uma breve revisão. Perspectivas da Ciência e Tecnologia. 2015; 7: 25-42.'},{id:"B58",body:'Razavi, S, Janfaza, S, Tasnim, N, Gibson, DL, Hoorfar, M. Mint: Nanomaterial-based encapsulation for controlled gastrointestinal delivery of viable probiotic bactéria. 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Mint: Nanoemulsion: preparation and its application in food industry. Emulsions. 2016: 153-191.'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Ilza Fernanda Barboza Duarte",address:null,affiliation:'
Programa de Pós-Graduação da Rede Nordeste de Biotecnologia (RENORBIO), Federal University of Alagoas, Brazil
Laboratory of New Nanostructured and Functional Materials, Physics Institute, Federal University of Alagoas, Brazil
Programa de Pós-Graduação da Rede Nordeste de Biotecnologia (RENORBIO), Federal University of Alagoas, Brazil
Laboratory of New Nanostructured and Functional Materials, Physics Institute, Federal University of Alagoas, Brazil
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The first part compares the diagnostic efficacy of traditional OCT and cross-polarization OCT (CP OCT); CP OCT and fluorescence cystoscopy (FC) for detecting flat lesions in the bladder at the early stages of cancer. The second part contains a report on achievements in application of CP OCT for detection of recurrent carcinoma in the scar area that is a hardly distinguishable form of bladder cancer using an optimized CP OCT image analysis. The third part of the chapter reviews the results on CP OCT usage for in vivo diagnosis of the bladder cancer after radiation therapy of cervical cancer.",signatures:"Elena Kiseleva, Gladkova Natalia, Streltzova Olga, Kirillin Mikhail,\nMaslennikova Anna, Dudenkova Varvara, Yunusova Katerina and\nSergeeva Ekaterina",authors:[{id:"68196",title:"Prof.",name:"Natalia",surname:"Gladkova",fullName:"Natalia Gladkova",slug:"natalia-gladkova",email:"natalia.gladkova@gmail.com"},{id:"191970",title:"Dr.",name:"Elena",surname:"Kiseleva",fullName:"Elena Kiseleva",slug:"elena-kiseleva",email:"kiseleva84@gmail.com"},{id:"191990",title:"Dr.",name:"Olga",surname:"Streltzova",fullName:"Olga Streltzova",slug:"olga-streltzova",email:"strelzova_uro@mail.ru"},{id:"191992",title:"Mrs.",name:"Varvara",surname:"Dudenkova",fullName:"Varvara Dudenkova",slug:"varvara-dudenkova",email:"orannge@mail.ru"},{id:"191993",title:"Prof.",name:"Anna",surname:"Maslennikova",fullName:"Anna Maslennikova",slug:"anna-maslennikova",email:"maslennikova.anna@gmail.com"},{id:"191994",title:"Dr.",name:"Katerina",surname:"Yunusova",fullName:"Katerina Yunusova",slug:"katerina-yunusova",email:"katyayunusova@yandex.ru"},{id:"191995",title:"Dr.",name:"Mikhail",surname:"Kirillin",fullName:"Mikhail Kirillin",slug:"mikhail-kirillin",email:"mkirillin@yandex.ru"},{id:"193422",title:"Dr.",name:"Ekaterina",surname:"Sergeeva",fullName:"Ekaterina Sergeeva",slug:"ekaterina-sergeeva",email:"sea@ufp.appl.sci-nnov.ru"}],book:{id:"5516",title:"Bladder Cancer",slug:"bladder-cancer-management-of-nmi-and-muscle-invasive-cancer",productType:{id:"1",title:"Edited Volume"}}}],collaborators:[{id:"68196",title:"Prof.",name:"Natalia",surname:"Gladkova",slug:"natalia-gladkova",fullName:"Natalia Gladkova",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Nizhny Novgorod State Medical Academy",institutionURL:null,country:{name:"Russia"}}},{id:"157535",title:"Associate Prof.",name:"Bulent",surname:"Erol",slug:"bulent-erol",fullName:"Bulent Erol",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"191356",title:"Dr.",name:"Alejandro",surname:"Sousa-Escandón",slug:"alejandro-sousa-escandon",fullName:"Alejandro Sousa-Escandón",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Santiago de Compostela",institutionURL:null,country:{name:"Spain"}}},{id:"191970",title:"Dr.",name:"Elena",surname:"Kiseleva",slug:"elena-kiseleva",fullName:"Elena Kiseleva",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/191970/images/system/191970.jpg",biography:"Elena B. Kiseleva, has a PhD in biology (Biophysics), she is a researcher of Laboratory of Optical coherence tomography (OCT) of the Privolzhskiy Research Medical University (Nizhny Novgorod, Russia). Her research ranges from optical imaging of biotissues, in particular, cross-polarization (CP) and angiographic OCT, polarization and nonlinear microscopy to histological evaluation of tumor and normal tissues response to different types of treatment (PDT, radiation therapy). She has contributed to the development of the numerical processing of CP OCT images (quantification of OCT signal and improvement the OCT contrast) for differential diagnostics of mucosal and brain diseases; to studies of myelinated fibers changes due to glioma invasion and radiation-induced changes of bladder and rectum collagen structure. Her research experience includes over 12 years in application of OCT devices in experimental and clinical studies. She is an author more than 70 publication on OCT.",institutionString:"Privolzhskiy Research Medical University",institution:{name:"Nizhny Novgorod State Medical Academy",institutionURL:null,country:{name:"Russia"}}},{id:"192375",title:"Prof.",name:"Mariapia",surname:"Viola-Magni",slug:"mariapia-viola-magni",fullName:"Mariapia Viola-Magni",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Perugia",institutionURL:null,country:{name:"Italy"}}},{id:"192686",title:"Dr.",name:"Turgay",surname:"Turan",slug:"turgay-turan",fullName:"Turgay Turan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"195411",title:"Prof.",name:"Asif",surname:"Yildirim",slug:"asif-yildirim",fullName:"Asif Yildirim",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"195412",title:"Prof.",name:"Turhan",surname:"Caskurlu",slug:"turhan-caskurlu",fullName:"Turhan Caskurlu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:null},{id:"197851",title:"BSc.",name:"Samuela",surname:"Cataldi",slug:"samuela-cataldi",fullName:"Samuela Cataldi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Perugia",institutionURL:null,country:{name:"Italy"}}},{id:"197852",title:"Dr.",name:"Daniela",surname:"Marocco",slug:"daniela-marocco",fullName:"Daniela Marocco",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Perugia",institutionURL:null,country:{name:"Italy"}}}]},generic:{page:{slug:"open-access-funding",title:"Open Access Funding",intro:"
IntechOpen’s Academic Editors and Authors have received funding for their work through many well-known funders, including: the European Commission, Bill and Melinda Gates Foundation, Wellcome Trust, Chinese Academy of Sciences, Natural Science Foundation of China (NSFC), CGIAR Consortium of International Agricultural Research Centers, National Institute of Health (NIH), National Science Foundation (NSF), National Aeronautics and Space Administration (NASA), National Institute of Standards and Technology (NIST), German Research Foundation (DFG), Research Councils United Kingdom (RCUK), Oswaldo Cruz Foundation, Austrian Science Fund (FWF), Foundation for Science and Technology (FCT), Australian Research Council (ARC).
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\\n\\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\\n\\n
\\n\\t
Does your institution already have a budget for covering Open Access publication costs?
\\n\\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\\n
\\n\\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
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Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
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Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
Open Access publication costs can often be designated directly in the grants or in specific budgets allocated for that purpose. Many of the most important funding organisations encourage, and even request, that the projects they fund are made available at no cost to the wider public. IntechOpen strives to maintain excellent relationships with these funders and ensures compliance with mandates.
\n\n
In order to help Authors identify appropriate funding agencies and institutions, we have created a list, based on extensive research on various OA resources (including ROARMAP and SHERPA/JULIET) of organizations that have funds available. Before consulting our list we encourage you to petition your own institution or organization for Open Access funds or check the specifications of your grant with your funder to ascertain if publication costs are included. Where you are in receipt of a grant you should clarify:
\n\n
\n\t
Does your institution already have a budget for covering Open Access publication costs?
\n\t
Does your grant list Open Access publication fees as legitimate direct/indirect costs?
\n
\n\n
If you are associated with any of the institutions in our list below, you can apply to receive OA publication funds by following the instructions provided in the links. Please consult the Open Access policies or grant Terms and Conditions of any institution with which you are linked to explore ways to cover your publication costs (also accessible by clicking on the link in their title).
\n\n
Please note that this list is not a definitive one and is updated regularly. To suggest possible modifications or the inclusion of your institution/funder, please contact us at funders@intechopen.com
\n\n
Please be aware that you must be a member, or grantee, of the institutions/funders listed in order to apply for their Open Access publication funds.
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Delac received his B.Sc.E.E. degree in 2003 and is currentlypursuing a Ph.D. degree at the University of Zagreb, Faculty of Electrical Engineering andComputing. His current research interests are digital image analysis, pattern recognition andbiometrics.",institutionString:null,institution:{name:"University of Zagreb",country:{name:"Croatia"}}},{id:"557",title:"Dr.",name:"Andon",middleName:"Venelinov",surname:"Topalov",slug:"andon-topalov",fullName:"Andon Topalov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/557/images/1927_n.jpg",biography:"Dr. Andon V. Topalov received the MSc degree in Control Engineering from the Faculty of Information Systems, Technologies, and Automation at Moscow State University of Civil Engineering (MGGU) in 1979. He then received his PhD degree in Control Engineering from the Department of Automation and Remote Control at Moscow State Mining University (MGSU), Moscow, in 1984. From 1985 to 1986, he was a Research Fellow in the Research Institute for Electronic Equipment, ZZU AD, Plovdiv, Bulgaria. In 1986, he joined the Department of Control Systems, Technical University of Sofia at the Plovdiv campus, where he is presently a Full Professor. He has held long-term visiting Professor/Scholar positions at various institutions in South Korea, Turkey, Mexico, Greece, Belgium, UK, and Germany. And he has coauthored one book and authored or coauthored more than 80 research papers in conference proceedings and journals. 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Leite",authors:[{id:"1164",title:"Dr.",name:"Fabio",middleName:"Lima",surname:"Leite",slug:"fabio-leite",fullName:"Fabio Leite"},{id:"136651",title:"MSc.",name:"Ricardo",middleName:null,surname:"De Oliveira",slug:"ricardo-de-oliveira",fullName:"Ricardo De Oliveira"},{id:"136652",title:"M.Sc.",name:"Diego",middleName:"Aparecido Carvalho",surname:"Albuquerque",slug:"diego-albuquerque",fullName:"Diego Albuquerque"},{id:"136653",title:"Prof.",name:"Tersio",middleName:null,surname:"Cruz",slug:"tersio-cruz",fullName:"Tersio Cruz"},{id:"136657",title:"Prof.",name:"Fabio",middleName:null,surname:"Yamaji",slug:"fabio-yamaji",fullName:"Fabio Yamaji"}]},{id:"49054",doi:"10.5772/60952",title:"Anion Exchange Resins as Effective Sorbents for Removal of Acid, Reactive, and Direct Dyes from Textile Wastewaters",slug:"anion-exchange-resins-as-effective-sorbents-for-removal-of-acid-reactive-and-direct-dyes-from-textil",totalDownloads:3184,totalCrossrefCites:24,totalDimensionsCites:47,abstract:"Coloured wastewaters are a consequence of batch processes in both dye-manufacturing and dye-consuming industries. Dyes are widely used in a number of industries, such as textile and leather dyeing, food, cosmetics, paper printing, gasoline, with the textile industry as the largest consumer. Dyeing as a fundamental operation during textile fibre processing causes the production of more or less coloured wastewaters, depending on the degree of fixation of dyes on substrates, which varies with the nature of substances, desired intensity of coloration, and application method. Dye bearing effluents are considered to be a very complex and inconsistent mixture of many pollutants ranging from dyes, dressing substances, alkalis, oils, detergents, salts of organic and inorganic acids to heavy metals.Thus after dyeing wastewaters are characterized not only by intensive and difficult for removal colour but also by high pH, suspended and dissolved solids, chemical and biochemical oxygen demands. Ion exchange is a very versatile and effective tool for treatment of aqueous hazardous wastes including dyes. The role of ion exchange in dye effluents treatment is to reduce the magnitude of hazardous load by converting them into a form in which they can be reused, leaving behind less toxic substances in their places or to facilitate ultimate disposal by reducing the hydraulic flow of the stream bearing toxic substances. Another significant feature of the ion exchange process is that it has the ability to separate as well as to concentrate pollutants. Taking into account high capacity and selectivity of ion exchange resins for different dyes, they seem to be proper materials for dyes sorption from textile effluents. The aim of the paper is to study the removal of the acid, reactive and direct textile dyes such as C.I. Acid Orange 7, C.I. Reactive Black 5 and C.I. Direct Blue 71 on the commercially available anion exchangers (Lewatit MonoPlus MP 62, Lewatit MonoPlus MP 64, Lewatit MonoPlus MP 500, Lewatit MonoPlus M 500, Amberlite IRA 67, Amberlite IRA 478RF, Amberlite IRA 458 and Amberlite IRA 958) differing not only in basicity of the functional groups but also in composition and structure of the matrix. Comparison of the sorption parameters obtained by the batch method taking into account influence of phase contact time, dyes initial concentration and solution pH were discussed in detail. Desorption conditions depending on the dyes sorption mechanism were also presented. Influence of the auxiliaries typically present in textile effluents such as inorganic electrolytes and different surfactants on the amounts of dyes retained by the anion exchangers was presented. The adsorption behaviour of the polyacrylic Amberlite IRA 958 demonstrates that it can be a promising adsorbent for the textile wastewater treatment. The results obtained with raw textile wastewaters purification confirmed this statement.",book:{id:"4599",slug:"ion-exchange-studies-and-applications",title:"Ion Exchange",fullTitle:"Ion Exchange - Studies and Applications"},signatures:"Monika Wawrzkiewicz and Zbigniew Hubicki",authors:[{id:"141883",title:"Prof.",name:"Zbigniew",middleName:null,surname:"Hubicki",slug:"zbigniew-hubicki",fullName:"Zbigniew Hubicki"},{id:"173310",title:"Dr.",name:"Monika",middleName:null,surname:"Wawrzkiewicz",slug:"monika-wawrzkiewicz",fullName:"Monika Wawrzkiewicz"}]},{id:"52110",doi:"10.5772/64935",title:"Electrodeposition from Deep Eutectic Solvents",slug:"electrodeposition-from-deep-eutectic-solvents",totalDownloads:3485,totalCrossrefCites:7,totalDimensionsCites:29,abstract:"Deep eutectic solvents constitute a class of compounds sharing many similarities with properly named ionic liquids. The accepted definition of ionic liquid is a fluid (liquid for T<100 °C) consisting of ions, while DES are eutectic mixtures of Lewis or Brønsted acids and bases. Their most attractive properties are the wide potential windows and the chemical properties largely different from aqueous solutions. In the last few decades, the possibility to electrodeposit decorative and functional coatings employing deep eutectic solvents as electrolytes has been widely investigated. A large number of the deposition procedures described in literature, however, cannot find application in the industrial practice due to competition with existing processes, cost or difficult scalability. From one side, there is the real potential to replace existing plating protocols and to find niche applications for high added-value productions; to the other one, this paves the path towards the electrodeposition of metals and alloys thermodynamically impossible to be obtained via usual aqueous solution processes. The main aim of this chapter is therefore the critical discussion of the applicability of deep eutectic solvents to the electrodeposition of metals and alloys, with a particular attention to the industrial and applicative point of view.",book:{id:"5381",slug:"progress-and-developments-in-ionic-liquids",title:"Ionic Liquids",fullTitle:"Progress and Developments in Ionic Liquids"},signatures:"R. Bernasconi, G. Panzeri, A. Accogli, F. Liberale, L. Nobili and L.\nMagagnin",authors:[{id:"188210",title:"Associate Prof.",name:"Luca",middleName:null,surname:"Magagnin",slug:"luca-magagnin",fullName:"Luca Magagnin"},{id:"194387",title:"MSc.",name:"Roberto",middleName:null,surname:"Bernasconi",slug:"roberto-bernasconi",fullName:"Roberto Bernasconi"},{id:"194388",title:"MSc.",name:"Gabriele",middleName:null,surname:"Panzeri",slug:"gabriele-panzeri",fullName:"Gabriele Panzeri"},{id:"194389",title:"MSc.",name:"Alessandra",middleName:null,surname:"Accogli",slug:"alessandra-accogli",fullName:"Alessandra Accogli"},{id:"194390",title:"MSc.",name:"Francesco",middleName:null,surname:"Liberale",slug:"francesco-liberale",fullName:"Francesco Liberale"},{id:"194391",title:"Prof.",name:"Luca",middleName:null,surname:"Nobili",slug:"luca-nobili",fullName:"Luca Nobili"}]},{id:"25422",doi:"10.5772/28293",title:"Electrochemical Polymerization of Aniline",slug:"electrochemical-polymerization-of-aniline",totalDownloads:11460,totalCrossrefCites:3,totalDimensionsCites:29,abstract:null,book:{id:"607",slug:"electropolymerization",title:"Electropolymerization",fullTitle:"Electropolymerization"},signatures:"Milica M. Gvozdenović, Branimir Z. Jugović, Jasmina S. Stevanović, Tomislav Lj. Trišović and Branimir N. Grgur",authors:[{id:"73400",title:"Dr.",name:"Milica",middleName:null,surname:"Gvozdenović",slug:"milica-gvozdenovic",fullName:"Milica Gvozdenović"},{id:"78801",title:"Dr.",name:"Branimir",middleName:null,surname:"Jugović",slug:"branimir-jugovic",fullName:"Branimir Jugović"},{id:"78807",title:"Dr.",name:"Jasmina",middleName:null,surname:"Stevanović",slug:"jasmina-stevanovic",fullName:"Jasmina Stevanović"},{id:"120374",title:"Dr.",name:"Tomislav",middleName:null,surname:"Trišović",slug:"tomislav-trisovic",fullName:"Tomislav Trišović"},{id:"120376",title:"Prof.",name:"Branimir",middleName:null,surname:"Grgur",slug:"branimir-grgur",fullName:"Branimir Grgur"}]}],mostDownloadedChaptersLast30Days:[{id:"52110",title:"Electrodeposition from Deep Eutectic Solvents",slug:"electrodeposition-from-deep-eutectic-solvents",totalDownloads:3487,totalCrossrefCites:7,totalDimensionsCites:29,abstract:"Deep eutectic solvents constitute a class of compounds sharing many similarities with properly named ionic liquids. The accepted definition of ionic liquid is a fluid (liquid for T<100 °C) consisting of ions, while DES are eutectic mixtures of Lewis or Brønsted acids and bases. Their most attractive properties are the wide potential windows and the chemical properties largely different from aqueous solutions. In the last few decades, the possibility to electrodeposit decorative and functional coatings employing deep eutectic solvents as electrolytes has been widely investigated. A large number of the deposition procedures described in literature, however, cannot find application in the industrial practice due to competition with existing processes, cost or difficult scalability. From one side, there is the real potential to replace existing plating protocols and to find niche applications for high added-value productions; to the other one, this paves the path towards the electrodeposition of metals and alloys thermodynamically impossible to be obtained via usual aqueous solution processes. The main aim of this chapter is therefore the critical discussion of the applicability of deep eutectic solvents to the electrodeposition of metals and alloys, with a particular attention to the industrial and applicative point of view.",book:{id:"5381",slug:"progress-and-developments-in-ionic-liquids",title:"Ionic Liquids",fullTitle:"Progress and Developments in Ionic Liquids"},signatures:"R. Bernasconi, G. Panzeri, A. Accogli, F. Liberale, L. Nobili and L.\nMagagnin",authors:[{id:"188210",title:"Associate Prof.",name:"Luca",middleName:null,surname:"Magagnin",slug:"luca-magagnin",fullName:"Luca Magagnin"},{id:"194387",title:"MSc.",name:"Roberto",middleName:null,surname:"Bernasconi",slug:"roberto-bernasconi",fullName:"Roberto Bernasconi"},{id:"194388",title:"MSc.",name:"Gabriele",middleName:null,surname:"Panzeri",slug:"gabriele-panzeri",fullName:"Gabriele Panzeri"},{id:"194389",title:"MSc.",name:"Alessandra",middleName:null,surname:"Accogli",slug:"alessandra-accogli",fullName:"Alessandra Accogli"},{id:"194390",title:"MSc.",name:"Francesco",middleName:null,surname:"Liberale",slug:"francesco-liberale",fullName:"Francesco Liberale"},{id:"194391",title:"Prof.",name:"Luca",middleName:null,surname:"Nobili",slug:"luca-nobili",fullName:"Luca Nobili"}]},{id:"74147",title:"Electrochemical Impedance Spectroscopy (EIS): A Review Study of Basic Aspects of the Corrosion Mechanism Applied to Steels",slug:"electrochemical-impedance-spectroscopy-eis-a-review-study-of-basic-aspects-of-the-corrosion-mechanis",totalDownloads:2662,totalCrossrefCites:11,totalDimensionsCites:21,abstract:"AC impedance measurements have been applied for over twenty years in electrochemistry and physics to investigate the electrical properties of conductive materials and their interfaces using an external electrical impulse (VOLTAGE, V or CURRENT, I) as driving force. Furthermore, its application has recently appeared to be destined in the Biotechnology field as an effective tool for rapid microbiologic diagnosis of living organism in situ. However, there is no doubt that the electrochemical impedance spectroscopy (EIS) is still one of the most useful techniques around the world for metal corrosion control and its monitoring. Corrosion has long been recognized as one of the most expensive stumbling blocks that concern many industries and government agencies, because it is a steel destructive phenomenon that occurs due to the chemical interaction with aqueous environments and takes place at the interface between metal and electrolyte producing an electrical charge transfer or ion diffusion process. Consequently, it is experimentally possible to determine through the EIS technique the mechanism and control that kinectics of corrosion reactions encounter. First, EIS data is collected through a potentiostat/galvanostat apparatus. After, it is fitted to a mathematical model (i.e. an equivalent electrical circuit, EEC) for its interpretation and analysis, fundamentally seeking a meaningful physical interpretation. Finally, this review reports some basic aspects of the corrosion mechanism applied to steels through the experimental EIS response using Nyquist or Bode plots. Examples are given for different applied electrochemical impedance cases in which steel is under study intentionally exposed to a corrosive aqueous solution by applying a sinusoidal potential at various test conditions.",book:{id:"10054",slug:"electrochemical-impedance-spectroscopy",title:"Electrochemical Impedance Spectroscopy",fullTitle:"Electrochemical Impedance Spectroscopy"},signatures:"Héctor Herrera Hernández, Adriana M. Ruiz Reynoso, Juan C. Trinidad González, Carlos O. González Morán, José G. Miranda Hernández, Araceli Mandujano Ruiz, Jorge Morales Hernández and Ricardo Orozco Cruz",authors:[{id:"114381",title:"Dr.",name:"Jorge",middleName:null,surname:"Morales-Hernandez",slug:"jorge-morales-hernandez",fullName:"Jorge Morales-Hernandez"},{id:"215540",title:"Dr.",name:"Araceli",middleName:null,surname:"Mandujano Ruiz",slug:"araceli-mandujano-ruiz",fullName:"Araceli Mandujano Ruiz"},{id:"268773",title:"Dr.",name:"Hector",middleName:null,surname:"Herrera Hernandez",slug:"hector-herrera-hernandez",fullName:"Hector Herrera Hernandez"},{id:"268774",title:"Dr.",name:"Carlos O.",middleName:null,surname:"Gonzalez Moran",slug:"carlos-o.-gonzalez-moran",fullName:"Carlos O. Gonzalez Moran"},{id:"314695",title:"Dr.",name:"Adriana Mercedes",middleName:null,surname:"Ruiz Reynoso",slug:"adriana-mercedes-ruiz-reynoso",fullName:"Adriana Mercedes Ruiz Reynoso"}]},{id:"62242",title:"Oxygen Reduction Reaction",slug:"oxygen-reduction-reaction",totalDownloads:4028,totalCrossrefCites:8,totalDimensionsCites:18,abstract:"In this chapter, the oxygen reduction reaction (ORR), which is one of the most important reactions in energy conversion systems such as fuel cells, including its reaction kinetics, is presented. Recent developments in electrocatalysts for ORR in fuel cells, including low and non-Pt electrocatalysts, metal oxides, transition metal macrocycles and chalgogenides, are discussed. Understanding of the interdependence of size, shape and activity of the electrocatalysts is evaluated. The recent development of ORR electrocatalysts with novel nanostructures is also reported. The mechanism catalysed by these electrocatalysts is presented. Finally, the perspectives of future trends for ORR are discussed.",book:{id:"6778",slug:"electrocatalysts-for-fuel-cells-and-hydrogen-evolution-theory-to-design",title:"Electrocatalysts for Fuel Cells and Hydrogen Evolution",fullTitle:"Electrocatalysts for Fuel Cells and Hydrogen Evolution - Theory to Design"},signatures:"Lindiwe Khotseng",authors:[{id:"236596",title:"Dr.",name:"Lindiwe Eudora",middleName:null,surname:"Khotseng",slug:"lindiwe-eudora-khotseng",fullName:"Lindiwe Eudora Khotseng"}]},{id:"40709",title:"The Role of Ion Exchange Chromatography in Purification and Characterization of Molecules",slug:"the-role-of-ion-exchange-chromatography-in-purification-and-characterization-of-molecules",totalDownloads:12954,totalCrossrefCites:2,totalDimensionsCites:9,abstract:null,book:{id:"2549",slug:"ion-exchange-technologies",title:"Ion Exchange Technologies",fullTitle:"Ion Exchange Technologies"},signatures:"Hidayat Ullah Khan",authors:[{id:"140538",title:"Dr.",name:"Hidayat",middleName:null,surname:"Khan",slug:"hidayat-khan",fullName:"Hidayat Khan"}]},{id:"49055",title:"Ion Exchange Method for Removal and Separation of Noble Metal Ions",slug:"ion-exchange-method-for-removal-and-separation-of-noble-metal-ions",totalDownloads:3029,totalCrossrefCites:6,totalDimensionsCites:12,abstract:"Ion exchange has been widely applied in technology of chemical separation of noble metal ions. This is associated with dissemination of methods using various ion exchange resins which are indispensable in many fields of chemical industry. Due to small amounts of noble elements in nature and constant impoverishment of their natural raw materials, of particular importance are physicochemical methods of their recovery from the second sources e.g. worn out converters of exhausted gases, chemical catalysts, dental alloys, anodic sludges from cooper and nickiel electrorefining as well as waste waters and running off waters from refineries containing trace amount of noble metals. It should be stated that these waste materials are usually pyro- and hydrometallurgically processed. Recovery of noble metals, from such raw materials requires individual approach to each material and application of selective methods for their removal. Moreover, separation of noble metals, particularly platinum metals and gold from geological samples, industrial products, synthetic mixtures along with other elements is a problem of significant importance nowadays. In the paper the research on the applicability of different types of ion exchangers for the separation of noble metals will be presented. The effect of the different parameters on their separation will be also discussed. The examples of the removal of noble metals chlorocomplexes will also be presented in detail.",book:{id:"4599",slug:"ion-exchange-studies-and-applications",title:"Ion Exchange",fullTitle:"Ion Exchange - Studies and Applications"},signatures:"Zbigniew Hubicki, Monika Wawrzkiewicz, Grzegorz Wójcik, Dorota\nKołodyńska and Anna Wołowicz",authors:[{id:"141883",title:"Prof.",name:"Zbigniew",middleName:null,surname:"Hubicki",slug:"zbigniew-hubicki",fullName:"Zbigniew Hubicki"},{id:"173610",title:"Dr.",name:"Dorota",middleName:null,surname:"Kołodyńska",slug:"dorota-kolodynska",fullName:"Dorota Kołodyńska"}]}],onlineFirstChaptersFilter:{topicId:"505",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:8,limit:8,total:0},allSeries:{pteSeriesList:[{id:"14",title:"Artificial Intelligence",numberOfPublishedBooks:9,numberOfPublishedChapters:90,numberOfOpenTopics:6,numberOfUpcomingTopics:0,issn:"2633-1403",doi:"10.5772/intechopen.79920",isOpenForSubmission:!0},{id:"7",title:"Biomedical Engineering",numberOfPublishedBooks:12,numberOfPublishedChapters:107,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2631-5343",doi:"10.5772/intechopen.71985",isOpenForSubmission:!0}],lsSeriesList:[{id:"11",title:"Biochemistry",numberOfPublishedBooks:33,numberOfPublishedChapters:330,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2632-0983",doi:"10.5772/intechopen.72877",isOpenForSubmission:!0},{id:"25",title:"Environmental Sciences",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2754-6713",doi:"10.5772/intechopen.100362",isOpenForSubmission:!0},{id:"10",title:"Physiology",numberOfPublishedBooks:14,numberOfPublishedChapters:145,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-8261",doi:"10.5772/intechopen.72796",isOpenForSubmission:!0}],hsSeriesList:[{id:"3",title:"Dentistry",numberOfPublishedBooks:9,numberOfPublishedChapters:139,numberOfOpenTopics:2,numberOfUpcomingTopics:0,issn:"2631-6218",doi:"10.5772/intechopen.71199",isOpenForSubmission:!0},{id:"6",title:"Infectious Diseases",numberOfPublishedBooks:13,numberOfPublishedChapters:122,numberOfOpenTopics:4,numberOfUpcomingTopics:0,issn:"2631-6188",doi:"10.5772/intechopen.71852",isOpenForSubmission:!0},{id:"13",title:"Veterinary Medicine and Science",numberOfPublishedBooks:11,numberOfPublishedChapters:112,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2632-0517",doi:"10.5772/intechopen.73681",isOpenForSubmission:!0}],sshSeriesList:[{id:"22",title:"Business, Management and Economics",numberOfPublishedBooks:1,numberOfPublishedChapters:21,numberOfOpenTopics:3,numberOfUpcomingTopics:0,issn:"2753-894X",doi:"10.5772/intechopen.100359",isOpenForSubmission:!0},{id:"23",title:"Education and Human Development",numberOfPublishedBooks:0,numberOfPublishedChapters:10,numberOfOpenTopics:1,numberOfUpcomingTopics:1,issn:null,doi:"10.5772/intechopen.100360",isOpenForSubmission:!0},{id:"24",title:"Sustainable Development",numberOfPublishedBooks:1,numberOfPublishedChapters:19,numberOfOpenTopics:5,numberOfUpcomingTopics:0,issn:"2753-6580",doi:"10.5772/intechopen.100361",isOpenForSubmission:!0}],testimonialsList:[{id:"6",text:"It is great to work with the IntechOpen to produce a worthwhile collection of research that also becomes a great educational resource and guide for future research endeavors.",author:{id:"259298",name:"Edward",surname:"Narayan",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259298/images/system/259298.jpeg",slug:"edward-narayan",institution:{id:"3",name:"University of Queensland",country:{id:null,name:"Australia"}}}},{id:"13",text:"The collaboration with and support of the technical staff of IntechOpen is fantastic. The whole process of submitting an article and editing of the submitted article goes extremely smooth and fast, the number of reads and downloads of chapters is high, and the contributions are also frequently cited.",author:{id:"55578",name:"Antonio",surname:"Jurado-Navas",institutionString:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRisIQAS/Profile_Picture_1626166543950",slug:"antonio-jurado-navas",institution:{id:"720",name:"University of Malaga",country:{id:null,name:"Spain"}}}}]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:"2753-6580",scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
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\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
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\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
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\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
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\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
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\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
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\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
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\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"August 2nd, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:1,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. 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He is an academic staff member of the Department of Reproduction and Artificial Insemination, Selçuk University, Turkey. He manages several studies on sperms and embryos and is an editorial board member for several international journals. His studies include sperm cryobiology, in vitro fertilization, and embryo production in animals.",institutionString:"Selçuk University, Faculty of Veterinary Medicine",institution:null},{id:"90846",title:"Prof.",name:"Yusuf",middleName:null,surname:"Bozkurt",slug:"yusuf-bozkurt",fullName:"Yusuf Bozkurt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/90846/images/system/90846.jpg",biography:"Yusuf Bozkurt has a BSc, MSc, and Ph.D. from Ankara University, Turkey. He is currently a Professor of Biotechnology of Reproduction in the field of Aquaculture, İskenderun Technical University, Turkey. His research interests include reproductive biology and biotechnology with an emphasis on cryo-conservation. He is on the editorial board of several international peer-reviewed journals and has published many papers. Additionally, he has participated in many international and national congresses, seminars, and workshops with oral and poster presentations. He is an active member of many local and international organizations.",institutionString:"İskenderun Technical University",institution:{name:"İskenderun Technical University",country:{name:"Turkey"}}},{id:"61139",title:"Dr.",name:"Sergey",middleName:null,surname:"Tkachev",slug:"sergey-tkachev",fullName:"Sergey Tkachev",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/61139/images/system/61139.png",biography:"Dr. Sergey Tkachev is a senior research scientist at the Institute of Fundamental Medicine and Biology, Kazan Federal University, Russia, and at the Institute of Chemical Biology and Fundamental Medicine SB RAS, Novosibirsk, Russia. He received his Ph.D. in Molecular Biology with his thesis “Genetic variability of the tick-borne encephalitis virus in natural foci of Novosibirsk city and its suburbs.” His primary field is molecular virology with research emphasis on vector-borne viruses, especially tick-borne encephalitis virus, Kemerovo virus and Omsk hemorrhagic fever virus, rabies virus, molecular genetics, biology, and epidemiology of virus pathogens.",institutionString:"Russian Academy of Sciences",institution:{name:"Russian Academy of Sciences",country:{name:"Russia"}}},{id:"310962",title:"Dr.",name:"Amlan",middleName:"Kumar",surname:"Patra",slug:"amlan-patra",fullName:"Amlan Patra",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/310962/images/system/310962.jpg",biography:"Amlan K. Patra, FRSB, obtained a Ph.D. in Animal Nutrition from Indian Veterinary Research Institute, India, in 2002. He is currently an associate professor at West Bengal University of Animal and Fishery Sciences. He has more than twenty years of research and teaching experience. He held previous positions at the American Institute for Goat Research, The Ohio State University, Columbus, USA, and Free University of Berlin, Germany. His research focuses on animal nutrition, particularly ruminants and poultry nutrition, gastrointestinal electrophysiology, meta-analysis and modeling in nutrition, and livestock–environment interaction. He has authored around 175 articles in journals, book chapters, and proceedings. Dr. Patra serves on the editorial boards of several reputed journals.",institutionString:null,institution:{name:"West Bengal University of Animal and Fishery Sciences",country:{name:"India"}}},{id:"53998",title:"Prof.",name:"László",middleName:null,surname:"Babinszky",slug:"laszlo-babinszky",fullName:"László Babinszky",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/53998/images/system/53998.png",biography:"László Babinszky is Professor Emeritus, Department of Animal Nutrition Physiology, University of Debrecen, Hungary. He has also worked in the Department of Animal Nutrition, University of Wageningen, Netherlands; the Institute for Livestock Feeding and Nutrition (IVVO), Lelystad, Netherlands; the Agricultural University of Vienna (BOKU); the Institute for Animal Breeding and Nutrition, Austria; and the Oscar Kellner Research Institute for Animal Nutrition, Rostock, Germany. In 1992, Dr. Babinszky obtained a Ph.D. in Animal Nutrition from the University of Wageningen. His main research areas are swine and poultry nutrition. He has authored more than 300 publications (papers, book chapters) and edited four books and fourteen international conference proceedings.",institutionString:"University of Debrecen",institution:{name:"University of Debrecen",country:{name:"Hungary"}}},{id:"201830",title:"Dr.",name:"Fernando",middleName:"Sanchez",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201830/images/5017_n.jpg",biography:"I am a professor at UANL since 1988. My research lines are the development of reproductive techniques in small ruminants. We also conducted research on sexual and social behavior in males.\nI am Mexican and study my professional career as an engineer in agriculture and animal science at UANL. Then take a masters degree in science in Germany (Animal breeding). Take a doctorate in animal science at the UANL.",institutionString:null,institution:{name:"Universidad Autónoma de Nuevo León",country:{name:"Mexico"}}},{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",institution:{name:"University of Trás-os-Montes and Alto Douro",country:{name:"Portugal"}}},{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,institution:{name:"University of Évora",country:{name:"Portugal"}}},{id:"283019",title:"Dr.",name:"Oudessa",middleName:null,surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/283019/images/system/283019.png",biography:"Dr. Kerro Dego is a veterinary microbiologist with training in veterinary medicine, microbiology, and anatomic pathology. Dr. Kerro Dego is an assistant professor of dairy health in the department of animal science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. He received his D.V.M. (1997), M.S. (2002), and Ph.D. (2008) degrees in Veterinary Medicine, Animal Pathology and Veterinary Microbiology from College of Veterinary Medicine, Addis Ababa University, Ethiopia; College of Veterinary Medicine, Utrecht University, the Netherlands and Western College of Veterinary Medicine, University of Saskatchewan, Canada respectively. He did his Postdoctoral training in microbial pathogenesis (2009 - 2015) in the Department of Animal Science, the University of Tennessee, Institute of Agriculture, Knoxville, Tennessee. Dr. Kerro Dego’s research focuses on the prevention and control of infectious diseases of farm animals, particularly mastitis, improving dairy food safety, and mitigation of antimicrobial resistance. Dr. Kerro Dego has extensive experience in studying the pathogenesis of bacterial infections, identification of virulence factors, and vaccine development and efficacy testing against major bacterial mastitis pathogens. Dr. Kerro Dego conducted numerous controlled experimental and field vaccine efficacy studies, vaccination, and evaluation of immunological responses in several species of animals, including rodents (mice) and large animals (bovine and ovine).",institutionString:"University of Tennessee at Knoxville",institution:{name:"University of Tennessee at Knoxville",country:{name:"United States of America"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón Poggi",slug:"juan-carlos-gardon-poggi",fullName:"Juan Carlos Gardón Poggi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",biography:"Juan Carlos Gardón Poggi received University degree from the Faculty of Agrarian Science in Argentina, in 1983. Also he received Masters Degree and PhD from Córdoba University, Spain. He is currently a Professor at the Catholic University of Valencia San Vicente Mártir, at the Department of Medicine and Animal Surgery. He teaches diverse courses in the field of Animal Reproduction and he is the Director of the Veterinary Farm. He also participates in academic postgraduate activities at the Veterinary Faculty of Murcia University, Spain. His research areas include animal physiology, physiology and biotechnology of reproduction either in males or females, the study of gametes under in vitro conditions and the use of ultrasound as a complement to physiological studies and development of applied biotechnologies. Routinely, he supervises students preparing their doctoral, master thesis or final degree projects.",institutionString:null,institution:{name:"Valencia Catholic University Saint Vincent Martyr",country:{name:"Spain"}}},{id:"309529",title:"Dr.",name:"Albert",middleName:null,surname:"Rizvanov",slug:"albert-rizvanov",fullName:"Albert Rizvanov",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/309529/images/9189_n.jpg",biography:'Albert A. Rizvanov is a Professor and Director of the Center for Precision and Regenerative Medicine at the Institute of Fundamental Medicine and Biology, Kazan Federal University (KFU), Russia. He is the Head of the Center of Excellence “Regenerative Medicine” and Vice-Director of Strategic Academic Unit \\"Translational 7P Medicine\\". Albert completed his Ph.D. at the University of Nevada, Reno, USA and Dr.Sci. at KFU. He is a corresponding member of the Tatarstan Academy of Sciences, Russian Federation. Albert is an author of more than 300 peer-reviewed journal articles and 22 patents. He has supervised 11 Ph.D. and 2 Dr.Sci. dissertations. Albert is the Head of the Dissertation Committee on Biochemistry, Microbiology, and Genetics at KFU.\nORCID https://orcid.org/0000-0002-9427-5739\nWebsite https://kpfu.ru/Albert.Rizvanov?p_lang=2',institutionString:"Kazan Federal University",institution:{name:"Kazan Federal University",country:{name:"Russia"}}},{id:"210551",title:"Dr.",name:"Arbab",middleName:null,surname:"Sikandar",slug:"arbab-sikandar",fullName:"Arbab Sikandar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210551/images/system/210551.jpg",biography:"Dr. Arbab Sikandar, PhD, M. Phil, DVM was born on April 05, 1981. He is currently working at the College of Veterinary & Animal Sciences as an Assistant Professor. He previously worked as a lecturer at the same University. \nHe is a Member/Secretory of Ethics committee (No. CVAS-9377 dated 18-04-18), Member of the QEC committee CVAS, Jhang (Regr/Gen/69/873, dated 26-10-2017), Member, Board of studies of Department of Basic Sciences (No. CVAS. 2851 Dated. 12-04-13, and No. CVAS, 9024 dated 20/11/17), Member of Academic Committee, CVAS, Jhang (No. CVAS/2004, Dated, 25-08-12), Member of the technical committee (No. CVAS/ 4085, dated 20,03, 2010 till 2016).\n\nDr. Arbab Sikandar contributed in five days hands-on-training on Histopathology at the Department of Pathology, UVAS from 12-16 June 2017. He received a Certificate of appreciation for contributions for Popularization of Science and Technology in the Society on 17-11-15. He was the resource person in the lecture series- ‘scientific writing’ at the Department of Anatomy and Histology, UVAS, Lahore on 29th October 2015. He won a full fellowship as a principal candidate for the year 2015 in the field of Agriculture, EICA, Egypt with ref. to the Notification No. 12(11) ACS/Egypt/2014 from 10 July 2015 to 25th September 2015.; he received a grant of Rs. 55000/- as research incentives from Director, Advanced Studies and Research, UVAS, Lahore upon publications of research papers in IF Journals (DR/215, dated 19-5-2014.. He obtained his PhD by winning a HEC Pakistan indigenous Scholarship, ‘Ph.D. fellowship for 5000 scholars – Phase II’ (2av1-147), 17-6/HEC/HRD/IS-II/12, November 15, 2012. \n\nDr. Sikandar is a member of numerous societies: Registered Veterinary Medical Practitioner (life member) and Registered Veterinary Medical Faculty of Pakistan Veterinary Medical Council. The Registration code of PVMC is RVMP/4298 and RVMF/ 0102.; Life member of the University of Veterinary and Animal Sciences, Lahore, Alumni Association with S# 664, dated: 6-4-12. ; Member 'Vets Care Organization Pakistan” with Reference No. VCO-605-149, dated 05-04-06. :Member 'Vet Crescent” (Society of Animal Health and Production), UVAS, Lahore.",institutionString:"University of Veterinary & Animal Science",institution:{name:"University of Veterinary and Animal Sciences",country:{name:"Pakistan"}}},{id:"311663",title:"Dr.",name:"Prasanna",middleName:null,surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311663/images/13261_n.jpg",biography:null,institutionString:null,institution:{name:"National Dairy Research Institute",country:{name:"India"}}},{id:"202192",title:"Dr.",name:"Catrin",middleName:null,surname:"Rutland",slug:"catrin-rutland",fullName:"Catrin Rutland",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",biography:"Catrin Rutland is an Associate Professor of Anatomy and Developmental Genetics at the University of Nottingham, UK. She obtained a BSc from the University of Derby, England, a master’s degree from Technische Universität München, Germany, and a Ph.D. from the University of Nottingham. She undertook a post-doctoral research fellowship in the School of Medicine before accepting tenure in Veterinary Medicine and Science. Dr. Rutland also obtained an MMedSci (Medical Education) and a Postgraduate Certificate in Higher Education (PGCHE). She is the author of more than sixty peer-reviewed journal articles, twelve books/book chapters, and more than 100 research abstracts in cardiovascular biology and oncology. She is a board member of the European Association of Veterinary Anatomists, Fellow of the Anatomical Society, and Senior Fellow of the Higher Education Academy. Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",country:{name:"United Kingdom"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",biography:"Samir El-Gendy is a Professor of anatomy and embryology at the faculty of veterinary medicine, Alexandria University, Egypt. Samir obtained his PhD in veterinary science in 2007 from the faculty of veterinary medicine, Alexandria University and has been a professor since 2017. Samir is an author on 24 articles at Scopus and 12 articles within local journals and 2 books/book chapters. His research focuses on applied anatomy, imaging techniques and computed tomography. Samir worked as a member of different local projects on E-learning and he is a board member of the African Association of Veterinary Anatomists and of anatomy societies and as an associated author at local and international journals. Orcid: https://orcid.org/0000-0002-6180-389X",institutionString:null,institution:{name:"Alexandria University",country:{name:"Egypt"}}},{id:"246149",title:"Dr.",name:"Valentina",middleName:null,surname:"Kubale",slug:"valentina-kubale",fullName:"Valentina Kubale",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246149/images/system/246149.jpg",biography:"Valentina Kubale is Associate Professor of Veterinary Medicine at the Veterinary Faculty, University of Ljubljana, Slovenia. Since graduating from the Veterinary faculty she obtained her PhD in 2007, performed collaboration with the Department of Pharmacology, University of Copenhagen, Denmark. She continued as a post-doctoral fellow at the University of Copenhagen with a Lundbeck foundation fellowship. She is the editor of three books and author/coauthor of 23 articles in peer-reviewed scientific journals, 16 book chapters, and 68 communications at scientific congresses. Since 2008 she has been the Editor Assistant for the Slovenian Veterinary Research journal. She is a member of Slovenian Biochemical Society, The Endocrine Society, European Association of Veterinary Anatomists and Society for Laboratory Animals, where she is board member.",institutionString:"University of Ljubljana",institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"258334",title:"Dr.",name:"Carlos Eduardo",middleName:null,surname:"Fonseca-Alves",slug:"carlos-eduardo-fonseca-alves",fullName:"Carlos Eduardo Fonseca-Alves",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/258334/images/system/258334.jpg",biography:"Dr. Fonseca-Alves earned his DVM from Federal University of Goias – UFG in 2008. He completed an internship in small animal internal medicine at UPIS university in 2011, earned his MSc in 2013 and PhD in 2015 both in Veterinary Medicine at Sao Paulo State University – UNESP. Dr. Fonseca-Alves currently serves as an Assistant Professor at Paulista University – UNIP teaching small animal internal medicine.",institutionString:null,institution:{name:"Universidade Paulista",country:{name:"Brazil"}}},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",biography:"María de la Luz García Pardo is an agricultural engineer from Universitat Politècnica de València, Spain. She has a Ph.D. in Animal Genetics. Currently, she is a lecturer at the Agrofood Technology Department of Miguel Hernández University, Spain. Her research is focused on genetics and reproduction in rabbits. The major goal of her research is the genetics of litter size through novel methods such as selection by the environmental sensibility of litter size, with forays into the field of animal welfare by analysing the impact on the susceptibility to diseases and stress of the does. Details of her publications can be found at https://orcid.org/0000-0001-9504-8290.",institutionString:null,institution:{name:"Miguel Hernandez University",country:{name:"Spain"}}},{id:"350704",title:"M.Sc.",name:"Camila",middleName:"Silva Costa",surname:"Ferreira",slug:"camila-ferreira",fullName:"Camila Ferreira",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/350704/images/17280_n.jpg",biography:"Graduated in Veterinary Medicine at the Fluminense Federal University, specialist in Equine Reproduction at the Brazilian Veterinary Institute (IBVET) and Master in Clinical Veterinary Medicine and Animal Reproduction at the Fluminense Federal University. She has experience in analyzing zootechnical indices in dairy cattle and organizing events related to Veterinary Medicine through extension grants. I have experience in the field of diagnostic imaging and animal reproduction in veterinary medicine through monitoring and scientific initiation scholarships. I worked at the Equus Central Reproduction Equine located in Santo Antônio de Jesus – BA in the 2016/2017 breeding season. I am currently a doctoral student with a scholarship from CAPES of the Postgraduate Program in Veterinary Medicine (Pathology and Clinical Sciences) at the Federal Rural University of Rio de Janeiro (UFRRJ) with a research project with an emphasis on equine endometritis.",institutionString:null,institution:null},{id:"41319",title:"Prof.",name:"Lung-Kwang",middleName:null,surname:"Pan",slug:"lung-kwang-pan",fullName:"Lung-Kwang Pan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41319/images/84_n.jpg",biography:null,institutionString:null,institution:null},{id:"125292",title:"Dr.",name:"Katy",middleName:null,surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/125292/images/system/125292.jpeg",biography:"Katy Satué Ambrojo received her Veterinary Medicine degree, Master degree in Equine Technology and doctorate in Veterinary Medicine from the Faculty of Veterinary, CEU-Cardenal Herrera University in Valencia, Spain.Dr. Satué is accredited as a Private University Doctor Professor, Doctor Assistant, and Contracted Doctor by AVAP (Agència Valenciana d'Avaluació i Prospectiva) and currently, as a full professor by ANECA (since January 2022). To date, Katy has taught 22 years in the Department of Animal Medicine and Surgery at the CEU-Cardenal Herrera University in undergraduate courses in Veterinary Medicine (General Pathology, integrated into the Applied Basis of Veterinary Medicine module of the 2nd year, Clinical Equine I of 3rd year, and Equine Clinic II of 4th year). Dr. Satué research activity is in the field of Endocrinology, Hematology, Biochemistry, and Immunology in the Spanish Purebred mare. She has directed 5 Doctoral Theses and 5 Diplomas of Advanced Studies, and participated in 11 research projects as a collaborating researcher. She has written 2 books and 14 book chapters in international publishers related to the area, and 68 scientific publications in international journals. Dr. Satué has attended 63 congresses, participating with 132 communications in international congresses and 19 in national congresses related to the area. Dr. Satué is a scientific reviewer for various prestigious international journals such as Animals, American Journal of Obstetrics and Gynecology, Veterinary Clinical Pathology, Journal of Equine Veterinary Science, Reproduction in Domestic Animals, Research Veterinary Science, Brazilian Journal of Medical and Biological Research, Livestock Production Science and Theriogenology, among others. Since 2014 she has been responsible for the Clinical Analysis Laboratory of the CEU-Cardenal Herrera University Veterinary Clinical Hospital.",institutionString:null,institution:null},{id:"201721",title:"Dr.",name:"Beatrice",middleName:null,surname:"Funiciello",slug:"beatrice-funiciello",fullName:"Beatrice Funiciello",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/201721/images/11089_n.jpg",biography:"Graduated from the University of Milan in 2011, my post-graduate education included CertAVP modules mainly on equines (dermatology and internal medicine) and a few on small animal (dermatology and anaesthesia) at the University of Liverpool. After a general CertAVP (2015) I gained the designated Certificate in Veterinary Dermatology (2017) after taking the synoptic examination and then applied for the RCVS ADvanced Practitioner status. After that, I completed the Postgraduate Diploma in Veterinary Professional Studies at the University of Liverpool (2018). My main area of work is cross-species veterinary dermatology.",institutionString:null,institution:null},{id:"291226",title:"Dr.",name:"Monica",middleName:null,surname:"Cassel",slug:"monica-cassel",fullName:"Monica Cassel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/291226/images/8232_n.jpg",biography:'Degree in Biological Sciences at the Federal University of Mato Grosso with scholarship for Scientific Initiation by FAPEMAT (2008/1) and CNPq (2008/2-2009/2): Project \\"Histological evidence of reproductive activity in lizards of the Manso region, Chapada dos Guimarães, Mato Grosso, Brazil\\". Master\\\'s degree in Ecology and Biodiversity Conservation at Federal University of Mato Grosso with a scholarship by CAPES/REUNI program: Project \\"Reproductive biology of Melanorivulus punctatus\\". PhD\\\'s degree in Science (Cell and Tissue Biology Area) \n at University of Sao Paulo with scholarship granted by FAPESP; Project \\"Development of morphofunctional changes in ovary of Astyanax altiparanae Garutti & Britski, 2000 (Teleostei, Characidae)\\". She has experience in Reproduction of vertebrates and Morphology, with emphasis in Cellular Biology and Histology. She is currently a teacher in the medium / technical level courses at IFMT-Alta Floresta, as well as in the Bachelor\\\'s degree in Animal Science and in the Bachelor\\\'s degree in Business.',institutionString:null,institution:null},{id:"442807",title:"Dr.",name:"Busani",middleName:null,surname:"Moyo",slug:"busani-moyo",fullName:"Busani Moyo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Gwanda State University",country:{name:"Zimbabwe"}}},{id:"439435",title:"Dr.",name:"Feda S.",middleName:null,surname:"Aljaser",slug:"feda-s.-aljaser",fullName:"Feda S. 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The applications of this research cover many related fields, such as biotechnology and medicine, where, for example, Bioinformatics contributes to faster drug design, DNA analysis in forensics, and DNA sequence analysis in the field of personalized medicine. Personalized medicine is a type of medical care in which treatment is customized individually for each patient. Personalized medicine enables more effective therapy, reduces the costs of therapy and clinical trials, and also minimizes the risk of side effects. Nevertheless, advances in personalized medicine would not have been possible without bioinformatics, which can analyze the human genome and other vast amounts of biomedical data, especially in genetics. The rapid growth of information technology enabled the development of new tools to decode human genomes, large-scale studies of genetic variations and medical informatics. The considerable development of technology, including the computing power of computers, is also conducive to the development of bioinformatics, including personalized medicine. In an era of rapidly growing data volumes and ever lower costs of generating, storing and computing data, personalized medicine holds great promises. Modern computational methods used as bioinformatics tools can integrate multi-scale, multi-modal and longitudinal patient data to create even more effective and safer therapy and disease prevention methods. Main aspects of the topic are: Applying bioinformatics in drug discovery and development; Bioinformatics in clinical diagnostics (genetic variants that act as markers for a condition or a disease); Blockchain and Artificial Intelligence/Machine Learning in personalized medicine; Customize disease-prevention strategies in personalized medicine; Big data analysis in personalized medicine; Translating stratification algorithms into clinical practice of personalized medicine.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/7.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11403,editor:{id:"351533",title:"Dr.",name:"Slawomir",middleName:null,surname:"Wilczynski",slug:"slawomir-wilczynski",fullName:"Slawomir Wilczynski",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035U1loQAC/Profile_Picture_1630074514792",biography:"Professor Sławomir Wilczyński, Head of the Chair of Department of Basic Biomedical Sciences, Faculty of Pharmaceutical Sciences, Medical University of Silesia in Katowice, Poland. 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