Genes associated with nitrogen use efficiency in wheat.
\\n\\n
Released this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\\n\\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\\n"}]',published:!0,mainMedia:{caption:"Highly Cited",originalUrl:"/media/original/117"}},components:[{type:"htmlEditorComponent",content:'IntechOpen is proud to announce that 191 of our authors have made the Clarivate™ Highly Cited Researchers List for 2020, ranking them among the top 1% most-cited.
\n\nThroughout the years, the list has named a total of 261 IntechOpen authors as Highly Cited. Of those researchers, 69 have been featured on the list multiple times.
\n\n\n\nReleased this past November, the list is based on data collected from the Web of Science and highlights some of the world’s most influential scientific minds by naming the researchers whose publications over the previous decade have included a high number of Highly Cited Papers placing them among the top 1% most-cited.
\n\nWe wish to congratulate all of the researchers named and especially our authors on this amazing accomplishment! We are happy and proud to share in their success!
Note: Edited in March 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"3705",leadTitle:null,fullTitle:"Programmable Logic Controller",title:"Programmable Logic Controller",subtitle:null,reviewType:"peer-reviewed",abstract:"Despite the great technological advancement experienced in recent years, Programmable Logic Controllers (PLC) are still used in many applications from the real world and still play a central role in infrastructure of industrial automation. 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Field",doi:"10.5772/intechopen.103126",slug:"nitrogen-use-efficiency-in-wheat-genome-to-field",body:'Cereal crops are widely farmed across the world in comparison to other crops. 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The utilization of Nin plants requires multiple phases, such as the initial N intake phase, followed by nitrogen reduction to usable forms, amino acid assimilation, translocation, and lastly, nitrogen remobilization to reproductive organs Figure 1 [5]. The grain yield per unit of nitrogen available in the soil is defined as NUE (nitrogen use efficiency) in the wheat crop Figure 1 [6]. NUE analysis gives information on plant responses to diverse nitrogen availability conditions. Nitrogen use efficiency may be quantified using a variety of formulas and ideas. Cereal NUE is determined by how efficiently plants gather nitrogen (uptake efficiency, NUpE) and how efficiently plants use the nitrogen that has been taken up (utilization efficiency, NUtE) Figure 1 [7]. NUpE is calculated by dividing the total amount of above-ground nitrogen content during harvest by the available N in the soil, whereas NUtE is calculated by dividing the nitrogen in grain tissues by the N in above-ground plant biomass at harvest (Figure 1). As a result, NUE is determined at harvest, i.e., at the conclusion of the crop cycle. The agronomic efficiency of plants evaluates the efficiency with which they convert applied nitrogen to grain yield, whereas the apparent nitrogen efficiency of plants absorbs nitrogen from the soil [8]. The physiological efficiency of plants is determined by the amount of nitrogen collected and converted to grain production. For major cereal crops, improving resource use efficiency is a must to mitigate the negative effects of greater yield with increased input consumption on the environment and natural resources. The challenge here is to pick the most fertilizer-sensitive stage, to create a plant that maximizes early nitrogen uptake, and to have qualities, such as early vegetative vigor and a large root system for effective fertilizer uptake, all while considering above and below ground components. Later in the growth phase, a plant’s ability to absorb and remobilize available nitrogen and carbon to the grain is crucial. Major issues include appropriate root phenotyping, genotype x environmental interactions, soil characteristics, water-nutrient management, and nutrient dynamics balance. The primary question is whether it is feasible to improve nutrient absorption while reducing excessive fertilizer input and safeguarding soil health while maintaining optimal production and grain protein content. Nanotechnology, particularly the use of nanofertilizers (1–100 nm in size), is helpful and has been shown to have positive outcomes, while a further study on the impact of nanofertilizers on specific crops is required [9]. Before delving into the biochemistry and genetics of nitrogen use efficiency improvement in cereal crops, it is necessary to comprehend the new potential source of nitrogen fertilizers, the effect of nitrogen at various stages of growth, the nitrogen status of the crop, and development and NUE in the effect of fertilizers [10]. Anhydrous ammonia (82% N), urea (46% N), ammonium nitrate (34% N), ammonium nitrate sulfate (26% N), and aqua ammonia (25% N) are among the fertilizer sources. Organic and inorganic nitrogen fertilizers are the two primary categories of nitrogen fertilizers. In terms of inorganic fertilizers, anhydrous ammonia application contributes the most nitrogen, i.e., greater than 80%. Aqua ammonia, also known as ammonium hydroxide, is the second most significant source of inorganic nitrogen fertilizers and comprises 25–29% ammonia by weight. Another type of nitrogen fertilizer is ammonium nitrate, which is an agronomically relevant mixture of two distinct types of nitrogen (NH4NO3). This type of fertilizer is said to improve wheat baking quality [11]. Urea [CO(NH2)2] is an organic kind of fertilizer [12].
Schematic representation of the relationship between the nitrogen sources, uptake, utilization, and conversion to the wheat grain yield.
The grain crop goes through numerous stages of development and growth. The rate of nutrient absorption in wheat varies with growth stage, variety, growing conditions, and environment. Detailed research of wheat’s nutrient absorption mechanisms is required to determine the optimal time and exact stage of fertilizer applications. Small amounts of nitrogen are required for seedling viability in the early stages. The mid-tillering stage uses almost half of the nitrogen required [13]. A high nitrogen dose, on the other hand, may damage seedlings and increase vegetative growth early in the season, resulting in poorer yields. Excess nitrogen might cause crop maturity to be pushed back. Nitrogen demand is said to be influenced by a number of factors, and NUE decreases when nitrogen application exceeds demand [14]. NUE is impacted by a number of variables [15], including soil type, the availability of other macro and micronutrients (phosphorus, potassium, etc.) in the soil, and crop rotation, which has been proven to affect nitrogen absorption and utilization [16]. Nitrogen fertilization is influenced by the intensity, timing, and depth of tillage [17, 18]. The most active subject of study to boost N fertilization yield is developing strategies for assessing nitrogen status. Satellite imaging [19], portable hyperspectral sensors [20], drones, chlorophyll meters (SPAD), red edge optical reflectance (R750/R710) [21], NDVI (normalized vegetation index), and RVI (ration vegetation index) [19] all offer the possibility of N estimation in less time.
Wild and primitive cereal crop species are currently undervalued as a source of unique nutrient utilization efficiency differences. Association studies exploiting the best alleles to be assembled in superior varieties, as well as the identification and characterization of candidate genes with non-synonymous and regulatory SNPs, will aid breeders in selecting specific donors to develop resource-efficient high-yielding wheat varieties. Furthermore, because yield and grain protein content, which represent nitrogen use efficiency, are inversely related, it is critical for breeders to design cultivation programs that achieve comparatively successful NUE without sacrificing grain yield [22], and it is critical to understand the details of various genetic, physiological, and biochemical factors affecting NUpE and NUtE to develop such cultivars.
Agronomic practices and field management also had a role in avoiding nitrogen loss to the environment [23]. The present chapter focuses on the myriad biochemical and genetic factors that influence NUE in both direct and indirect ways. The biochemistry of nitrogen absorption and utilization, as well as the genetic system that controls NUE in cereals and the phenotypic results that positively influence NUE, are all covered in this chapter. The associated cereals study will aid in the development of approaches for enhancing NUE while maintaining other desirable characteristics.
Nutrient availability has a big influence on root growth and root system design. To present, little is known about the root architectural plasticity features, genetic foundation, mechanism, control, and function [24] linked to nutrient absorption. The root architecture is thought to be a key factor in NUE enhancement [25]. In cereal crops (wheat, rice, and maize), root systems can be separated into two types—embryonic (seminal roots) and post-embryonic roots (crown roots). The “steep, inexpensive, and deep” root architecture explains nutrient absorption, especially nitrogen absorption, rather well [26]. It specifies that main roots are responsible for obtaining nitrogen from deeper layers, whilst lateral roots with steep angles are responsible for covering a larger area of soil [27]. Lateral roots are said to be more vulnerable to biotic and abiotic stress, as well as fluctuating nitrogen concentration. Low nitrogen concentration promotes lateral root initiation in the early stages, while severe nitrogen deprivation prevents root emergence and elongation. In the soil, a high nitrate to ammonia ratio had a favorable effect on lateral root length [28].
Understanding the role of root traits in nutrient uptake and dissecting the genetic basis to maximize the potential to breed high-yielding resource-efficient varieties of cereal crops by using modern biotechnological and bioinformatic approaches is required to address the challenge of efficient nutrient uptake. It is critical to uncover the latent potential of root characteristics for enhancing nutrient absorption and identifying important marker correlations that may be used in molecular breeding to develop resource-efficient cultivars. The use of a suitable root prototype as well as strong marker-trait associations/QTL/candidate genes may help to solve the problem of nutrient insufficiency and inadequate nutrient absorption. Efforts to design a robust root system architecture that combines a variety of root traits (nodal root, root hair length, root hair density, root length density, root dry weight, percent lateral root, root branching, root thickness, and root volume) could be a solution to the problem of efficient nutrient uptake, particularly nitrogen (N) (Figure 2). The development of root architecture is said to be influenced by a number of elements both above and below ground [25]. At different phases of crop growth and development, different root characteristics are critical for nutrient absorption. Root size and morphological features are directly related to nitrogen uptake efficiency, as it has been observed that among the various forms of nitrogenous compounds present in the soil, particularly nitrate, easily escapes the soil system through leaching, implying the need to improve nitrogen uptake by improving root architecture, including depth, density, and capacity of roots for post-anthesis N uptake [29]. Although primary investigations in Arabidopsis were conducted to determine the molecular regulation of root architecture, multiple homologs in rice and other cereal crops have been found [30]. In wheat, the NAM, ATAF, and CUC transcription factors (TaNAC2-5A) stimulated root growth, whereas the NUCLEAR FACTOR Y (TaNFYA-B1) accelerated root development [31].
Role of above and below ground N-affecting factors, G × E × M interactions playing significant roles in the development of root architecture at different stages of plant development.
In wheat, root growth was found to have an important role in increasing nitrogen absorption [32]. As a result, the rooting profile required for nitrate absorption at lower depths was investigated by measuring root length density at a threshold of 1 cm/cm3 [33], where root length density is a measurement of root length per unit volume of soil [24]. Wheat roots showed a significant level of genetic diversity [24, 34]. Furthermore, a variety of environmental conditions, including soil type and nutrient availability, have a significant impact on root spreading characteristics. Deeper rooting systems have been observed in
Along with root length and density, root hairs are an essential feature to consider for increased nitrogen absorption by active transport. Root hairs play a significant role in increasing the surface area of roots, which may boost nitrogen uptake by active transport. It is challenging to target specific genes for enhanced nitrogen absorption since root structure and function appear to be the result of the cumulative influence of numerous genes [36]. The strategy for increasing nitrogen absorption comprises marker-assisted selection and pyramiding numerous advantageous characteristics. The quantitative trait loci (QTL) for traits, such as root length, root hair number, root density, root angle, and root-to-shoot ratio, are well established in wheat [37, 38], but there is a need to understand the mechanism of orchestrated expression of multiple traits affecting root architecture to positively influence nitrogen uptake.
Nitrogen transporters for nitrate (NO3−), ammonium (NH4+), amino acids or peptides, and urea are involved in nitrogen absorption [39, 40]. Nitrogen accumulation by roots is an active process that is mediated by a specific type of nitrogen transport protein. The most common inorganic form of nitrogen in the rhizosphere is NO−3, NH+4 is also present in the soil, although at much lower concentrations than NO3− [41]. The uptake and transport of nitrate in plants are mediated by five transporter families—the Nitrate Transporter 1/Peptide Transporter (NPF) family [42], the Nitrate Transporter 2 (NRT2) family, the Chloride Channel (CLC) family, the Slow Anion Associated Channel Homolog (SLC/SLAH) family, and aluminum-activated malate transporters (ALMT) [42]. Among the five families described above, NPF and NRT2 have been linked to nitrate absorption and plant localization.
Several kinds of plasma membrane-associated transporter proteins have been identified as being engaged in active transport and have been classed as high- and low-affinity transporters [43, 44]. In higher plants, three types of transport systems are active based on affinity and NO3− content in the rhizosphere—inducible high-affinity transport system (iHATS), constitutively expressed high-affinity transport system (cHATS), and nonsaturable low-affinity transport system (LATS). iHATS is activated at low NO3− concentrations (1–200 lM), and its activity varies depending on plant type and environmental conditions [45]. In wheat, iHATS has a Michaelis constant (Km) of around 27 lM and requires a 10-h induction time before commencing the transport process [46] cHATS, as the name implies, is constitutively produced and exhibited on the plasma membrane even in the absence of NO3−. Both cHATS and iHATS have the trait of becoming saturated once the external NO3− concentration reaches a particular threshold. The third, LATS, has low-affinity transporters and is activated when there is a high concentration of NO3− in the soil (250 lM). Unlike cHATS and iHATS, LATS contains nonsaturable transporters [47].
The rhizosphere is the area of the soil that comes into direct contact with the root system, and the organisms that dwell there have a substantial influence on mineral intake, particularly nitrogen uptake by roots [53]. Many higher plants, including wheat, are believed to emit a variety of exudates, including organic acids and sugars, that have a direct influence on the physiological activities of microbes in the root system [54]. Several environmental factors, including climate, water level, soil type, and agricultural practices, also have an influence on these microbial communities [55]. The microbial ecology of the rhizosphere has also been discovered to differ among wheat cultivars [56, 57]. Through the denitrification process, several bacteria minimize nitrogen consumption by converting inorganic nitrates to gaseous nitrogen [58]. As previously stated, denitrification converts nitrogen into an inaccessible form, hence suppressing such processes improves nitrogen absorption; nevertheless, the mechanism in cultivated cereal crops is not well-known [59]. Several attempts have been made to transfer beneficial root-microbial traits from wild relatives of domesticated cereal crops to domesticated cereal crops. A chromosome from Leymusracemosus, a wild wheat relative capable of preventing nitrification in the root rhizosphere, was transferred into cultivated wheat varieties [60, 61].
Improved nitrogen fixation can boost root nitrogen absorption. Although these nitrogen-fixing bacteria are a natural component of the wheat root rhizosphere [62, 63], the artificial introduction of N fixers may increase nitrogen intake, which has a favorable effect on production [64, 65]. The main option for introducing the legume-like system of nitrogen fixation from bacteria to cereal crops is genetic engineering [66]. The non-host-specific endophyte
Nitrate is an essential component of the nitrogen cycle and a major player in inorganic nitrogen assimilation in cereals [75]. The nitrate assimilation is primarily driven by its reduction and incorporation of nitrogen into the carbon skeleton to generate biologically active, organic nitrogen form. Nitrate uptake in plants is root transporter-mediated, inside root cells nitrate is targeted by nitrate reductase (NR) enzyme along with NAD(P)H cofactor. NR is the key enzyme that is involved in the very first step of nitrogen utilization and its conversion into biologically active molecules. It is reported that in hexaploid wheat two genes encode the NADH-dependent nitrate reductase [76]. NR leads to the conversion of nitrate into nitrite. Nitrite is further reduced to ammonia by the action of enzyme nitrite reductase (NiR) which is usually present in plastids of the plant cell [77]. In the case of NiR, ferredoxin is associated with NiR and the electrons for reduction are provided by ferredoxin [78]. Ammonia released by the action of NiR is used for amino acid formation. The primary amino acid involved in ammonia incorporation is glutamate. Glutamine synthetase (GS) and glutamate synthase (GOGAT) are the two enzymes that act in conjugation for amino acid formation [79]. GS is present in two isoforms in different cellular organelles. GS1 is prevalent in the cytosol of plant cells and GS2 works in plastids of roots and etiolated tissues [79]. It is reported that in wheat, the expression of GS2 is uniform throughout the plant development and comes to a halt toward maturity, and the expression of GS1 isoenzyme is consistently observed in senescing tissues and phloem [80]. Second enzyme GOGAt or glutamate synthase works with the primary enzyme in the formation of two amino acids glutamate and glutamine. These two amino acids are further involved in amino acid, nucleic acid formation by acting as donors of the amino group for nitrogen-containing compounds [79]. Two isomeric forms of GOGAT are present in the plant system. Both isoforms vary in terms of cofactors that they use and the process they are involved in. One is FD-GOGAT; this form is ferredoxin dependent; it is involved in the reassimilation of ammonia released from the cycle of photorespiration. The second isoform of GOGAT is NADH dependent which is primarily involved in amino acid synthesis which is channelized for protein formation involved in the growth and development of photosynthetic and accessory organs [79]. Almost 95% of ammonia availed by plants is dependent on GS and GOGAT as reported from several mutational studies [79]. These amino acids lead to increased protein formation which ultimately enhances productivity [81].
Multiple factors are reported to affect nitrogen assimilation but carbon metabolism is the major player having direct interaction with nitrogen metabolic pathways. The role of photosynthesis on nitrogen accumulation was analyzed in different target plants to dissect the interaction between carbon and nitrogen metabolic pathways. It was observed that nitrogen assimilation was changed when the photosynthetic rate was changed and vice versa. This is so because carbon fixation requires enzymes, such as RuBISCO, and as enzymes are protein a continuous flow of amino acid is needed for enzyme formation which further depends upon nitrogen availability [82]. So, nitrogen is critically important as it affects the photosynthetic activity which further regulates crop yield. Along with it, nitrogen metabolism is dependent on carbon metabolism as most of the enzymes involved in nitrogen metabolism need electron donors for their activity which is provided by carbon metabolism. Along with it, the GS/GOGAT pathway requires a carbon skeleton (Ketoglutarate) for ammonia assimilation which is the product of the TCA (tri carboxylic acid) cycle, an important regulator of carbon metabolism. So, carbon skeleton and other accessory elements needed for nitrate assimilation are provided by the carbon cycle [83]. So, overall nitrate assimilation is an interlinked metabolic pathway where several factors of carbon metabolism are critically related. Therefore, NUE is affected directly by components of nitrogen metabolic pathways and indirectly by players of carbon metabolism [75]. So, while targeting breeding programs for enhanced NUE enzymes and proteins associated with nitrogen and carbon metabolism can be targeted.
As discussed earlier, carbon fixation is an important process of plant growth and development. Rubisco is the major enzyme regulating the most critical step of Calvin cycle. Rubisco is the most abundant protein in the biosphere. The nitrogen accumulated by the plant is directly related to the amount of Rubisco formed which further defines the photosynthetic activity of the mesophyll cells. Almost 75% of N in wheat leaves is driven toward Rubisco enzyme formation which is important for photosynthesis [84, 85]. It is reported that in nitrogen-limited conditions, Rubisco content decreases which lead to reduced photosynthetic activity and reduced organic matter production. It is observed that photosynthetic activity is associated with leaf morphogenesis as it is the main region for carbon fixation. Leaf structure and canopy directly affect the yield output in crop plants [86]. High NUE increases the nitrogen uptake and utilization which enhances source and sink abilities and increases dry matter output and crop yield. The theory of optimization for canopy photosynthesis indicates that the coefficient of both light gradient (KL) and nitrogen (KN) positively contributes to photosynthesis [86]. Although the gradients for nitrogen observed in wheat were less steep than optimization theory [86]. Nitrogen utilization is majorly affected by the photosynthetic rate per unit of nitrogen. In light-saturated conditions, the photosynthetic rate was increased by 20–30 lmol CO2/m2/s for around 2 g N/m2 in C3 crops, such as wheat. The important aspect to target nitrogen utilization efficiency is to identify wheat cultivars with the capacity of accumulating around 2.0 g N/m2 under favorable conditions. A wide range of genetic variability was observed among various wheat lines specific leaf nitrogen (SLN) which is an indicator of leaf nitrogen content per unit leaf area. In earlier, Araus et al. [87] were grown a panel of 144 durum wheat genotypes in two rain-fed conditions and 125 of these were grown under supplementary irrigation before heading stage, and revealed that the SLN in these genotypes varied from 1.4 to 2.6 g/m2. Another study by Giunta et al. [88] reported that SLN varied from 2.1 to 2.4 g/m2 for the 17 durum wheat cultivars. A study in 16 bread wheat cultivars SLN varied from 1.4 to 2.2 g/m2 [86]. The nitrogen content in different tissues, including stem, leaf lamina, and leaf sheath, at anthesis show heritability of >0.60 under low nitrogen in winter wheat. So, these traits can be used in targeted breeding programs [89]. The genetic diversity associated with nitrogen utilization efficiency in wheat germplasm can be used to achieve the desired modification in photosynthetic components. It was reported earlier that around 30% improvement in photosynthesis can be attained by targeting photo-respiration, along with its other mechanisms contributing to 15–22% increase in photosynthetic activity [90]. There is a need to understand the intricacy of the molecular mechanisms affecting the pathways for leaf development, photorespiration, and majorly photosynthesis. The recent advancement in technologies for gene editings, such as CRISPR-Cas9 or specific promoter expression can be used in regulating pathways for leave development. This can generate diverse germplasm with high NUE and ultimately high yield potential [91].
Nitrogen distribution in the plant is source-sink relation dependent. Initially nitrogen uptake by roots acting as source and transpiration of absorbed nitrogen from roots to leaves and buds acting as major sink organ. This source-sink relation changes with the plant’s developmental stage, as it is observed that toward maturity the capability of the plant for nitrogen uptake decreases so the root does not act as a major source of nitrogen for the rest of the plant. During maturity, the leaf acts as a source, as toward senescence the old leaves die off and their protein components are degraded to release nitrogen which is remobilized to the younger leaves [92]. Leaf lamina is a major storage house of nitrogen in above-ground tissue during anthesis in wheat under optimal N supply. Other tissues, such as true stem, ear, and leaf sheath, also retain nitrogen [93], whereas the trend of nitrogen accumulation changes under nitrogen-limiting conditions, with more nitrogen in ears as compared to other parts of the plant [93]. Although, the NUE is majorly determined by nitrogen remobilization from leaves to its developing parts during the grain-filling stage which further defines the crop yield. So, during the grain-filling stage, the photosynthates and proteins stored in the older leaves act as a major source of nutrients for developing seeds. Autophagy is the basic mechanism that affects remobilization during the grain-filling stage. Autophagy is programmed cell death for the regulated release of stored compounds which is regulated by senescence-associated genes (ATG and metacaspases) [94]. Specific tissue-specific transporters are activated during the reproductive stage which is important for nitrogen remobilization. NRT1.7 is an important nitrogen transporter and its gene is reported to be controlled by nitrogen limitation adaptation regulators which are further under the control of miRNA827 [95]. This double-level control over tissue-specific nitrogen transporters suggests that the remobilization of nitrogen is tightly regulated. The remobilization process is under multiple regulatory controls along with transporters the enzymes, such as GOGAT, are reported to be involved in ammonia recycling during remobilization [96]. Along with its certain transcription factors, such as NAM-B1, efficiently increase nitrogen remobilization toward grains from mature leaves in wheat [97]. As in the case of cereals grain nitrogen, almost 50–90% is contributed by nitrogen from leaves [5]. The stage of nitrogen remobilization in grains from flag leaves can be used as a phenotypic marker [97]. As it is established that an inverse relation exists between grain yield and grain protein content, so higher grain yield is associated with delayed senescence of flag leaf in cereals. Among multiple proteins present in the leaf during senescence, the Rubisco (the most abundant protein in the biosphere) acts as a major contributor to remobilized nitrogen. In older leaves, chloroplast is degraded first as compared to other cellular components because of upregulation of proteases enzymes [98]. The tissue breakdown in older tissue is programmed by autophagy (chloroplast and Rubisco degradation) by the action of exopeptidases and endopeptidases present in cell vacuoles during senescence [98].
The stay-green phenotype is a marker for the tendency of a genotype to remain green during the grain-filling stage. The plants with stay-green phenotype remain photosynthetically active after anthesis [99]. Stay green-phenotype is a trait of interest to enhance NUE in plants and a wide range of genetic diversity is reported for this trait in hexaploid wheat [100]. Along with stay-green phenotypes traits, such as Rubisco degradation, and stem nitrogen assimilation are important targets for efficient nitrogen remobilization to the grains post-anthesis. The target of high yield with balanced protein content in wheat depends on an in-depth understanding of the mechanisms affecting post-anthesis nitrogen accumulation and remobilization toward developing grains.
In cereals, endosperm contributes to the maximum nutritive value of the grain due to its size ratio as compared to germ. The metabolic composition of endosperm is very essential for grain with high nutritive value. In cereals, starch is the prevalent biomolecule, along with its protein is also present with starch. Among different storage forms, Gluten is the major storage fraction of endosperm. Glutens have two components polymeric glutenins and monomeric gliadins. This storage protein contributes to 60–70% of the nitrogen in seed endosperm. Glutens provide the dough-making properties to wheat. Gliadin is responsible for dough viscosity and glutelins ensure dough elasticity. This dough-making capacity is important for consumable products of wheat, including pasta, bread, and noodles. The gluten synthesis is dependent on the protein accumulation which depends on the nitrogen utilization efficiency. Grain protein quality changes under different genetic backgrounds in wheat [101, 102]. Grain protein content and grain yield are both affected by NUtE although they are inversely related to each other [22, 103] which creates a barrier in attaining both simultaneously. The inverse relation between grain yield and grain protein content is due to metabolic competition between carbon and nitrogen fluxes for biomolecule accumulation [104], so dilution in NUtE depends on the accumulation of carbon-based compounds [105]. The efficient nitrogen in grain can be calculated by calculating grain protein deviation (GPD). GPD is a measure of deviation from the regression between grain protein concentration (GPC) and grain yield. Identification of genotypes with higher GPC from an expected GY can be estimated by calculating GPD [106]. In cereals, grain yield is dependent on coordinated regulation between several factors, majorly competition between photosynthesis and photorespiration [107]. The correlation between yield and nitrogen uptake and utilization is important for high wheat yields. There is a need to completely understand the mechanisms and regulatory pathways for nutrient uptake and its transport to stems, sheaths, leaves, and finally to developing grains. Along with this, it is important to understand the mechanisms for improvement of slow and ineffective filling of grains [108].
The number of genetic factors is associated with controlling NUE traits for cereal crops that include majorly six categories—transporters, signal molecules, amino acid biosynthesis, nitrate assimilation, transcription factors, and other genes. The upregulation and downregulation of these genes depend on nitrogen levels in the environment and thus are controlled by mechanisms as discussed in the following text.
One of the complex quantitative traits is nitrogen use efficiency (NUE) which is controlled by multiple genes and dissected using a powerful tool called QTL mapping [109, 110]. A successful QTL mapping for such a complicated trait relies on various factors, such as the selection of suitable parents, appropriate population size, multi-location testing, and genome coverage. QTL is conventionally affected by environmental variation where constitutive QTL is consistent over environments, while adaptive QTL shows an expression in a specific environment, or modulates its effect with a change in an environment. QTL analysis provides ample opportunities to identify correlations among different traits. A genetically and functionally linked trait is evident through co-localized QTL linked to phenotypically different traits.
Nitrogen use efficiency of cereal crops can be improved by employing classical genetics involving both conventional breeding and QTL mapping in combination with marker-assisted selection (MAS). To develop genomic knowledge for complex genomes of cereal crops, such as wheat, advances in next-generation sequencing and agronomically relevant traits can now be identified [111]. Wheat improvement could be heightened with the identification of cheap, easy-to-use, widely distributed, codominant, trait-associated, and regulatory SNPs, candidate genes, and regulatory pathways. Association mapping studies assist in accessing allelic diversity and identifying the best alleles to be assembled in superior varieties. Accuracy for identifying QTL for nitrogen uptake and utilization-related traits can be improved by using high-throughput genotyping techniques. In this regard, several promising means have also been proposed, such as focusing on root architecture [112] or senescence and remobilization [113].
Previous case studies reported various QTLs for NUE in the model crop plant, i.e.,
The identification of genomic regions (QTL) associated with nitrogen response would enable more efficient cultivar selection [121]. This approach allows breeders to proficiently develop high nitrogen use efficient cultivars by screening germplasm and studying the genetic markers associated with nitrogen response. As per previous work on rice and wheat, identification of the novel traits, alleles, genes/QTL, adapted breeding lines, landraces, and wild relatives improving NUE differences in cereal crops were well established. Using bi-parental populations, genes/QTL influencing nitrogen uptake have been mapped in wheat under different doses of fertilizer application [122, 123]. Genome-wide association studies for nitrogen uptake and use efficiency associated with variability and marker-trait selection have been reported [95, 124]. The development of synthetic wheat introgression libraries through Genome-wide association studies (GWAS) was made possible at Punjab Agricultural University, Ludhiana (India) to exploit their phenotypic variability. Several marker-trait associations related to root and plant morphological traits, grain yield, and yield-related traits have been well documented. Other than wheat, rice also shows highly conserved sequences, new genes, and regulatory elements to link genomes, genes, proteins, and traits controlling traits of interest across different species and genera through comparative mapping. These inter-genome relational patterns can lead to new hypotheses, knowledge, and predictions about the related species and can pave the way for genetic gain for future cereal crops.
Regulation of nitrogen utilization efficiencies, such as nitrogen absorption, accumulation, and remobilization, is controlled by multiple sets of genes in crop plants (wheat, rice, etc.). These genes are majorly classified into six categories, including transporters, signal molecules, amino acid biosynthesis, nitrate assimilation, transcription factors, and other genes. The detailed description of genes regulating nitrogen use efficiency in wheat crops is presented in Table 1. Transporters and nitrate assimilation genes actively participate in nitrogen uptake, while amino acid biosynthesis genes are involved in nitrogen utilization. On the contrary, signaling molecules, transcription factors, and other genes have a passive role in both nitrogen uptake and nitrogen utilization [126, 127]. Nitrate, being the most common form of nitrogen present in soil needs to be transported in a plant which is done by nitrate transporters that encode for NRT families. The first reported case was studied in
Category | Gene | Chr | Location | IWGSC Gene ID | References |
---|---|---|---|---|---|
Nitrogen transporters | 1A | 373,766,258–373,768,702 | [125] | ||
1A | 14,519,757–14,525,659 | [125] | |||
1A | 355,624,056–355,628,073 | [5] | |||
1B | 385,644,930–385,648,470 | [5] | |||
1D | 284,040,636–284,044,349 | [5] | |||
2A | 17,869,278–17,871,731 | [125] | |||
3A | 540,654,271–540,656,804 | [125] | |||
3A | 660,436,466–660,444,074 | [125] | |||
3B | 457,633,984–457,635,782 | [5] | |||
3D | 356,623,041–356,624,585 | [5] | |||
4A | 640,232,228–640,233,158 | [5] | |||
4B | 483,508,916–483,514,108 | [5] | |||
5A | 3,085,412–3,088,853 | [125] | |||
5A | 34,980,804–34,986,700 | [125] | |||
5A | 599,204,895–599,208,619 | [125] | |||
6A | 486,547,388–486,550,355 | [125] | |||
6AL/BL/DL | 486,547,388–486,550,355 | [125] | |||
6B | 415,788,848–415,790,024 | [5] | |||
6B | 458,486,050–458,487,918 | [5] | |||
6D | 267,236,634–267,237,837 | [5] | |||
6D | 293,801,873–293,803,683 | [5] | |||
7A | 169,020,411–169,025,550 | [42] | |||
7A | 109,262,804–109,265,004 | [5] | |||
7B | 583,923,053–583,926,829 | [5] | |||
N assimilation | 6B | 636,392,631–636,397,024 | [5] | ||
6D | 422,078,484–422,081,985 | [5] | |||
Amino acid biosynthesis (glutamine synthase) | 1A | 71,689,760–71,695,155 | [5] | ||
1A | 553,535,726–553,542,082 | [5] | |||
1A | 287,681,550–287,684,692 | [5] | |||
1B | 112,748,629–112,753,960 | [5] | |||
1B | 635,920,024–635,926,285 | [5] | |||
1B | 317,791,804–317,795,107 | [5] | |||
1D | 221,915,283–221,918,343 | [5] | |||
2D | 301,816,850–301,819,891 | [5] | |||
3A | 541,257,235–541,261,301 | [5] | |||
3B | 536,074,881–536,079,450 | [5] | |||
3B | 481,595,302–481,606,660 | [5] | |||
3D | 369,790,549–369,802,074 | [5] | |||
4B | 417,737,785–417,741,607 | [5] | |||
4B | 499,898,695–499,901,767 | [5] | |||
4B | 573,273,107–573,276,702 | [5] | |||
4B | 363,644,060–363,647,074 | [5] | |||
5B | 74,659,823–74,670,378 | [5] | |||
5B | 107,190,378–107,196,256 | [5] | |||
5D | 494,216,160–494,219,691 | [5] | |||
6B | 668,432,728–668,437,537 | [5] | |||
6B | 577,183,711–577,187,787 | [5] | |||
6AL/BL/DL | 531,394,366–531,398,363 | [125] | |||
Transcription factors | 1A | 572,334,701–572,336,969 | [5] | ||
1B | 662,783,949–662,786,278 | [5] | |||
3B | 605,665,548–605,668,470 | [5] | |||
3D | 458,624,044–458,626,934 | [5] | |||
4B | 639,452,139–639,453,299 | [5] | |||
5B | 133,417,326–133,419,111 | [5] | |||
5B | 13,081,769–13,086,120 | [5] | |||
5D | 13,313,304–13,318,505 | [5] | |||
6B/1B | 51,579,298–51,580,659 | [5] | |||
Other genes (kinases) | 1A | 381,819,326–381,822,599 | [5] | ||
1B | 411,987,863–411,990,884 | [5] | |||
1D | 304,838,300–304,841,343 | [5] | |||
(Rubisco) | 2A | 171,076,784–171,079,172 | [89] |
Genes associated with nitrogen use efficiency in wheat.
Nitrate transporters, although are the main players in nitrogen uptake in most plants, in certain cases, such as rice, ammonia is the predominant form in the soil. Nitrogen uptake is followed by nitrogen assimilation. A crucial metabolic step regulating the grain yield and NUE is the nitrogen uptake followed by nitrogen assimilation in the form of amino acids which is usually carried out by glutamine synthetase (GS)/glutamate synthase (GOGAT) cycle. Increased GS1 activity is observed in the leaves of wheat crop directing an accumulation of nitrogen in grains and also enhanced dry grain matter. At high N content, the GS1 gene gets overexpressed thereby enhancing the nitrogen harvest index and NUE while at low N content, NUE does not change. Nitrogen remobilization is the last step in nitrogen use efficiency (NUE) for seeds during maturity. Generally monocots, dicots, C3, and C4 plants share a common mechanism for the nitrogen remobilization [5]. Asparagine and glutamine are common amino acid transport forms for nitrogen remobilization from leaves to reproductive tissues catalyzed by enzymes GS and GOGAT, respectively [129]. In durum wheat, asparagine synthetase encoding genes (AsnS1) are prominent for nitrogen remobilization from flag leaf to developing grains where their concentration increase in phloem sap during senescence of leaves [130]. Leaf senescence affects high yield in cereal crops as even though delayed leaf promotes prolonged photosynthesis for improving grain yield, it however decreases nitrogen remobilization efficiency and grain protein content [5].
Plant regulatory network is governed by transcription factors and like several other metabolic processes, NUE imperatively relies on coordinated transcription factors presented in Table 1 [131]. Transcription factors for lateral root growth in response to nitrate belong to the MADS-box family analogous to ANR1, a transcription factor reported in
miRNAs have been reported to play a significant role in NUE along with several transcription factors. The miRNA169 family is instigated to regulate the expression of genes for nitrogen transport in durum wheat under the nitrogen starvation stage in both roots and leaves [133]. In a recent study on the durum wheat plant, ttu-miR169h and ttu-miR169c at the seedling and grain-filling stages and ttu-novel-61 belonging to the miR169family showed down-regulation under nitrogen-deficient conditions in both roots and leaves. These miRNAs negatively regulate the CCAAT box-binding transcription factors in several tissues influencing NUE-related genes in durum wheat plants [133]. Another report indicated the role of the NAM-B1 gene in bread wheat as a NAC transcription factor that affects the grain nutrient concentration as well as increases the remobilization of nutrients from leaves to developing grains in wild wheat [134].
At low nitrogen levels, upregulation of TaMIR1129, TaMIR1118, and TaMIR1136 and downregulation of TaMIR1133 in roots of wheat were reported. The miRNA expression was inversely proportional to the concentration and duration of nitrogen application [135]. A gradual uprise in the expression of TaMIR2275 during nitrogen starvation was observed which was restored progressively once nitrogen level is recovered. Overexpression of produced plants with increased nitrogen accumulation and biomass is obtained from overexpression of TaMIR2275, while knockdown mutants showed the reverse. Inevitably, several classes of miRNAs are involved in nitrogen metabolism by altering multiple processes associated directly or indirectly with NUE. To comprehend, it is crucial to have a deep understanding of the precise network of miRNA expression and interaction for channelizing the mechanism underlying NUE.
The development of nutrient efficient varieties calls for the identification of suitable traits, and candidate genes underlying QTL that may provide new opportunities for the introgression of these QTL and genes into elite genetic backgrounds (Figure 3).
Schematic representation of flow work to the development of nitrogen-efficient wheat genotypes.
Immense use of nitrogen fertilizers even though uplift grain yields of cereal crops, negatively affect the environment by causing water, soil, air pollution, and greenhouse gas emissions. It thus poses an economic impact globally due to the high production costs of nitrogen fertilizer. To combat this, the challenge to improve NUE in cereal crops lies in achieving both high yield and high nitrogen use efficiency (NUE) simultaneously. Crop improvement can be achieved by improving our knowledge of agronomic management, suitable traits, QTL, genes, and the mechanisms and functions of genes associated with nitrogen use efficiency. Selection of diverse genotypes, exploitation of natural variation, exploring root architecture, high-throughput precise phenotyping, standardized field trials, new techniques for efficient fertilizer application, appropriate field management practices, and identification of new QTL/genes/nitrogen transporters, as well as signaling molecules, could contribute in reducing fertilizer consumption in the near future. Thus, an improvement in basic research in combination with agronomical, marker-aided molecular breeding and biotechnological strategies will help to achieve higher nitrogen use efficiency in cereal crops.
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His research interest focuses on computational chemistry and molecular modeling of diverse systems of pharmacological, food, and alternative energy interests by resorting to DFT and Conceptual DFT. He has authored a coauthored more than 255 peer-reviewed papers, 32 book chapters, and 2 edited books. He has delivered speeches at many international and domestic conferences. He serves as a reviewer for more than eighty international journals, books, and research proposals as well as an editor for special issues of renowned scientific journals.",institutionString:"Centro de Investigación en Materiales Avanzados",institution:{name:"Centro de Investigación en Materiales Avanzados",country:{name:"Mexico"}}},{id:"76477",title:"Prof.",name:"Mirza",middleName:null,surname:"Hasanuzzaman",slug:"mirza-hasanuzzaman",fullName:"Mirza Hasanuzzaman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/76477/images/system/76477.png",biography:"Dr. Mirza Hasanuzzaman is a Professor of Agronomy at Sher-e-Bangla Agricultural University, Bangladesh. He received his Ph.D. in Plant Stress Physiology and Antioxidant Metabolism from Ehime University, Japan, with a scholarship from the Japanese Government (MEXT). Later, he completed his postdoctoral research at the Center of Molecular Biosciences, University of the Ryukyus, Japan, as a recipient of the Japan Society for the Promotion of Science (JSPS) postdoctoral fellowship. He was also the recipient of the Australian Government Endeavour Research Fellowship for postdoctoral research as an adjunct senior researcher at the University of Tasmania, Australia. Dr. Hasanuzzaman’s current work is focused on the physiological and molecular mechanisms of environmental stress tolerance. Dr. Hasanuzzaman has published more than 150 articles in peer-reviewed journals. He has edited ten books and written more than forty book chapters on important aspects of plant physiology, plant stress tolerance, and crop production. According to Scopus, Dr. Hasanuzzaman’s publications have received more than 10,500 citations with an h-index of 53. He has been named a Highly Cited Researcher by Clarivate. He is an editor and reviewer for more than fifty peer-reviewed international journals and was a recipient of the “Publons Peer Review Award” in 2017, 2018, and 2019. He has been honored by different authorities for his outstanding performance in various fields like research and education, and he has received the World Academy of Science Young Scientist Award (2014) and the University Grants Commission (UGC) Award 2018. He is a fellow of the Bangladesh Academy of Sciences (BAS) and the Royal Society of Biology.",institutionString:"Sher-e-Bangla Agricultural University",institution:{name:"Sher-e-Bangla Agricultural University",country:{name:"Bangladesh"}}},{id:"187859",title:"Prof.",name:"Kusal",middleName:"K.",surname:"Das",slug:"kusal-das",fullName:"Kusal Das",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSBDeQAO/Profile_Picture_1623411145568",biography:"Kusal K. Das is a Distinguished Chair Professor of Physiology, Shri B. M. Patil Medical College and Director, Centre for Advanced Medical Research (CAMR), BLDE (Deemed to be University), Vijayapur, Karnataka, India. Dr. Das did his M.S. and Ph.D. in Human Physiology from the University of Calcutta, Kolkata. His area of research is focused on understanding of molecular mechanisms of heavy metal activated low oxygen sensing pathways in vascular pathophysiology. He has invented a new method of estimation of serum vitamin E. His expertise in critical experimental protocols on vascular functions in experimental animals was well documented by his quality of publications. He was a Visiting Professor of Medicine at University of Leeds, United Kingdom (2014-2016) and Tulane University, New Orleans, USA (2017). For his immense contribution in medical research Ministry of Science and Technology, Government of India conferred him 'G.P. Chatterjee Memorial Research Prize-2019” and he is also the recipient of 'Dr.Raja Ramanna State Scientist Award 2015” by Government of Karnataka. He is a Fellow of the Royal Society of Biology (FRSB), London and Honorary Fellow of Karnataka Science and Technology Academy, Department of Science and Technology, Government of Karnataka.",institutionString:"BLDE (Deemed to be University), India",institution:null},{id:"243660",title:"Dr.",name:"Mallanagouda Shivanagouda",middleName:null,surname:"Biradar",slug:"mallanagouda-shivanagouda-biradar",fullName:"Mallanagouda Shivanagouda Biradar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243660/images/system/243660.jpeg",biography:"M. S. Biradar is Vice Chancellor and Professor of Medicine of\nBLDE (Deemed to be University), Vijayapura, Karnataka, India.\nHe obtained his MD with a gold medal in General Medicine and\nhas devoted himself to medical teaching, research, and administrations. He has also immensely contributed to medical research\non vascular medicine, which is reflected by his numerous publications including books and book chapters. Professor Biradar was\nalso Visiting Professor at Tulane University School of Medicine, New Orleans, USA.",institutionString:"BLDE (Deemed to be University)",institution:{name:"BLDE University",country:{name:"India"}}},{id:"289796",title:"Dr.",name:"Swastika",middleName:null,surname:"Das",slug:"swastika-das",fullName:"Swastika Das",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/289796/images/system/289796.jpeg",biography:"Swastika N. Das is Professor of Chemistry at the V. P. Dr. P. G.\nHalakatti College of Engineering and Technology, BLDE (Deemed\nto be University), Vijayapura, Karnataka, India. She obtained an\nMSc, MPhil, and PhD in Chemistry from Sambalpur University,\nOdisha, India. Her areas of research interest are medicinal chemistry, chemical kinetics, and free radical chemistry. She is a member\nof the investigators who invented a new modified method of estimation of serum vitamin E. She has authored numerous publications including book\nchapters and is a mentor of doctoral curriculum at her university.",institutionString:"BLDEA’s V.P.Dr.P.G.Halakatti College of Engineering & Technology",institution:{name:"BLDE University",country:{name:"India"}}},{id:"248459",title:"Dr.",name:"Akikazu",middleName:null,surname:"Takada",slug:"akikazu-takada",fullName:"Akikazu Takada",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248459/images/system/248459.png",biography:"Akikazu Takada was born in Japan, 1935. After graduation from\nKeio University School of Medicine and finishing his post-graduate studies, he worked at Roswell Park Memorial Institute NY,\nUSA. He then took a professorship at Hamamatsu University\nSchool of Medicine. In thrombosis studies, he found the SK\npotentiator that enhances plasminogen activation by streptokinase. He is very much interested in simultaneous measurements\nof fatty acids, amino acids, and tryptophan degradation products. By using fatty\nacid analyses, he indicated that plasma levels of trans-fatty acids of old men were\nfar higher in the US than Japanese men. . He also showed that eicosapentaenoic acid\n(EPA) and docosahexaenoic acid (DHA) levels are higher, and arachidonic acid\nlevels are lower in Japanese than US people. By using simultaneous LC/MS analyses\nof plasma levels of tryptophan metabolites, he recently found that plasma levels of\nserotonin, kynurenine, or 5-HIAA were higher in patients of mono- and bipolar\ndepression, which are significantly different from observations reported before. In\nview of recent reports that plasma tryptophan metabolites are mainly produced by\nmicrobiota. He is now working on the relationships between microbiota and depression or autism.",institutionString:"Hamamatsu University School of Medicine",institution:{name:"Hamamatsu University School of Medicine",country:{name:"Japan"}}},{id:"137240",title:"Prof.",name:"Mohammed",middleName:null,surname:"Khalid",slug:"mohammed-khalid",fullName:"Mohammed Khalid",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/137240/images/system/137240.png",biography:"Mohammed Khalid received his B.S. degree in chemistry in 2000 and Ph.D. degree in physical chemistry in 2007 from the University of Khartoum, Sudan. He moved to School of Chemistry, Faculty of Science, University of Sydney, Australia in 2009 and joined Dr. Ron Clarke as a postdoctoral fellow where he worked on the interaction of ATP with the phosphoenzyme of the Na+/K+-ATPase and dual mechanisms of allosteric acceleration of the Na+/K+-ATPase by ATP; then he went back to Department of Chemistry, University of Khartoum as an assistant professor, and in 2014 he was promoted as an associate professor. In 2011, he joined the staff of Department of Chemistry at Taif University, Saudi Arabia, where he is currently an assistant professor. His research interests include the following: P-Type ATPase enzyme kinetics and mechanisms, kinetics and mechanisms of redox reactions, autocatalytic reactions, computational enzyme kinetics, allosteric acceleration of P-type ATPases by ATP, exploring of allosteric sites of ATPases, and interaction of ATP with ATPases located in cell membranes.",institutionString:"Taif University",institution:{name:"Taif University",country:{name:"Saudi Arabia"}}},{id:"63810",title:"Prof.",name:"Jorge",middleName:null,surname:"Morales-Montor",slug:"jorge-morales-montor",fullName:"Jorge Morales-Montor",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/63810/images/system/63810.png",biography:"Dr. Jorge Morales-Montor was recognized with the Lola and Igo Flisser PUIS Award for best graduate thesis at the national level in the field of parasitology. He received a fellowship from the Fogarty Foundation to perform postdoctoral research stay at the University of Georgia. He has 153 journal articles to his credit. He has also edited several books and published more than fifty-five book chapters. He is a member of the Mexican Academy of Sciences, Latin American Academy of Sciences, and the National Academy of Medicine. He has received more than thirty-five awards and has supervised numerous bachelor’s, master’s, and Ph.D. students. Dr. Morales-Montor is the past president of the Mexican Society of Parasitology.",institutionString:"National Autonomous University of Mexico",institution:{name:"National Autonomous University of Mexico",country:{name:"Mexico"}}},{id:"217215",title:"Dr.",name:"Palash",middleName:null,surname:"Mandal",slug:"palash-mandal",fullName:"Palash Mandal",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217215/images/system/217215.jpeg",biography:null,institutionString:"Charusat University",institution:null},{id:"49739",title:"Dr.",name:"Leszek",middleName:null,surname:"Szablewski",slug:"leszek-szablewski",fullName:"Leszek Szablewski",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49739/images/system/49739.jpg",biography:"Leszek Szablewski is a professor of medical sciences. He received his M.S. in the Faculty of Biology from the University of Warsaw and his PhD degree from the Institute of Experimental Biology Polish Academy of Sciences. He habilitated in the Medical University of Warsaw, and he obtained his degree of Professor from the President of Poland. Professor Szablewski is the Head of Chair and Department of General Biology and Parasitology, Medical University of Warsaw. Professor Szablewski has published over 80 peer-reviewed papers in journals such as Journal of Alzheimer’s Disease, Biochim. Biophys. Acta Reviews of Cancer, Biol. Chem., J. Biomed. Sci., and Diabetes/Metabol. Res. Rev, Endocrine. He is the author of two books and four book chapters. He has edited four books, written 15 scripts for students, is the ad hoc reviewer of over 30 peer-reviewed journals, and editorial member of peer-reviewed journals. Prof. Szablewski’s research focuses on cell physiology, genetics, and pathophysiology. He works on the damage caused by lack of glucose homeostasis and changes in the expression and/or function of glucose transporters due to various diseases. He has given lectures, seminars, and exercises for students at the Medical University.",institutionString:"Medical University of Warsaw",institution:{name:"Medical University of Warsaw",country:{name:"Poland"}}},{id:"173123",title:"Dr.",name:"Maitham",middleName:null,surname:"Khajah",slug:"maitham-khajah",fullName:"Maitham Khajah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/173123/images/system/173123.jpeg",biography:"Dr. Maitham A. Khajah received his degree in Pharmacy from Faculty of Pharmacy, Kuwait University, in 2003 and obtained his PhD degree in December 2009 from the University of Calgary, Canada (Gastrointestinal Science and Immunology). Since January 2010 he has been assistant professor in Kuwait University, Faculty of Pharmacy, Department of Pharmacology and Therapeutics. His research interest are molecular targets for the treatment of inflammatory bowel disease (IBD) and the mechanisms responsible for immune cell chemotaxis. He cosupervised many students for the MSc Molecular Biology Program, College of Graduate Studies, Kuwait University. Ever since joining Kuwait University in 2010, he got various grants as PI and Co-I. He was awarded the Best Young Researcher Award by Kuwait University, Research Sector, for the Year 2013–2014. He was a member in the organizing committee for three conferences organized by Kuwait University, Faculty of Pharmacy, as cochair and a member in the scientific committee (the 3rd, 4th, and 5th Kuwait International Pharmacy Conference).",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"195136",title:"Dr.",name:"Aya",middleName:null,surname:"Adel",slug:"aya-adel",fullName:"Aya Adel",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/195136/images/system/195136.jpg",biography:"Dr. Adel works as an Assistant Lecturer in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. Dr. Adel is especially interested in joint attention and its impairment in autism spectrum disorder",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"94911",title:"Dr.",name:"Boulenouar",middleName:null,surname:"Mesraoua",slug:"boulenouar-mesraoua",fullName:"Boulenouar Mesraoua",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94911/images/system/94911.png",biography:"Dr Boulenouar Mesraoua is the Associate Professor of Clinical Neurology at Weill Cornell Medical College-Qatar and a Consultant Neurologist at Hamad Medical Corporation at the Neuroscience Department; He graduated as a Medical Doctor from the University of Oran, Algeria; he then moved to Belgium, the City of Liege, for a Residency in Internal Medicine and Neurology at Liege University; after getting the Belgian Board of Neurology (with high marks), he went to the National Hospital for Nervous Diseases, Queen Square, London, United Kingdom for a fellowship in Clinical Neurophysiology, under Pr Willison ; Dr Mesraoua had also further training in Epilepsy and Continuous EEG Monitoring for two years (from 2001-2003) in the Neurophysiology department of Zurich University, Switzerland, under late Pr Hans Gregor Wieser ,an internationally known epileptologist expert. \n\nDr B. Mesraoua is the Director of the Neurology Fellowship Program at the Neurology Section and an active member of the newly created Comprehensive Epilepsy Program at Hamad General Hospital, Doha, Qatar; he is also Assistant Director of the Residency Program at the Qatar Medical School. \nDr B. Mesraoua's main interests are Epilepsy, Multiple Sclerosis, and Clinical Neurology; He is the Chairman and the Organizer of the well known Qatar Epilepsy Symposium, he is running yearly for the past 14 years and which is considered a landmark in the Gulf region; He has also started last year , together with other epileptologists from Qatar, the region and elsewhere, a yearly International Epilepsy School Course, which was attended by many neurologists from the Area.\n\nInternationally, Dr Mesraoua is an active and elected member of the Commission on Eastern Mediterranean Region (EMR ) , a regional branch of the International League Against Epilepsy (ILAE), where he represents the Middle East and North Africa(MENA ) and where he holds the position of chief of the Epilepsy Epidemiology Section; Dr Mesraoua is a member of the American Academy of Neurology, the Europeen Academy of Neurology and the American Epilepsy Society.\n\nDr Mesraoua's main objectives are to encourage frequent gathering of the epileptologists/neurologists from the MENA region and the rest of the world, promote Epilepsy Teaching in the MENA Region, and encourage multicenter studies involving neurologists and epileptologists in the MENA region, particularly epilepsy epidemiological studies. \n\nDr. Mesraoua is the recipient of two research Grants, as the Lead Principal Investigator (750.000 USD and 250.000 USD) from the Qatar National Research Fund (QNRF) and the Hamad Hospital Internal Research Grant (IRGC), on the following topics : “Continuous EEG Monitoring in the ICU “ and on “Alpha-lactoalbumin , proof of concept in the treatment of epilepsy” .Dr Mesraoua is a reviewer for the journal \"seizures\" (Europeen Epilepsy Journal ) as well as dove journals ; Dr Mesraoua is the author and co-author of many peer reviewed publications and four book chapters in the field of Epilepsy and Clinical Neurology",institutionString:"Weill Cornell Medical College in Qatar",institution:{name:"Weill Cornell Medical College in Qatar",country:{name:"Qatar"}}},{id:"282429",title:"Prof.",name:"Covanis",middleName:null,surname:"Athanasios",slug:"covanis-athanasios",fullName:"Covanis Athanasios",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/282429/images/system/282429.jpg",biography:null,institutionString:"Neurology-Neurophysiology Department of the Children Hospital Agia Sophia",institution:null},{id:"190980",title:"Prof.",name:"Marwa",middleName:null,surname:"Mahmoud Saleh",slug:"marwa-mahmoud-saleh",fullName:"Marwa Mahmoud Saleh",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/190980/images/system/190980.jpg",biography:"Professor Marwa Mahmoud Saleh is a doctor of medicine and currently works in the unit of Phoniatrics, Department of Otolaryngology, Ain Shams University in Cairo, Egypt. She got her doctoral degree in 1991 and her doctoral thesis was accomplished in the University of Iowa, United States. Her publications covered a multitude of topics as videokymography, cochlear implants, stuttering, and dysphagia. She has lectured Egyptian phonology for many years. Her recent research interest is joint attention in autism.",institutionString:"Ain Shams University",institution:{name:"Ain Shams University",country:{name:"Egypt"}}},{id:"259190",title:"Dr.",name:"Syed Ali Raza",middleName:null,surname:"Naqvi",slug:"syed-ali-raza-naqvi",fullName:"Syed Ali Raza Naqvi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/259190/images/system/259190.png",biography:"Dr. Naqvi is a radioanalytical chemist and is working as an associate professor of analytical chemistry in the Department of Chemistry, Government College University, Faisalabad, Pakistan. Advance separation techniques, nuclear analytical techniques and radiopharmaceutical analysis are the main courses that he is teaching to graduate and post-graduate students. In the research area, he is focusing on the development of organic- and biomolecule-based radiopharmaceuticals for diagnosis and therapy of infectious and cancerous diseases. Under the supervision of Dr. Naqvi, three students have completed their Ph.D. degrees and 41 students have completed their MS degrees. He has completed three research projects and is currently working on 2 projects entitled “Radiolabeling of fluoroquinolone derivatives for the diagnosis of deep-seated bacterial infections” and “Radiolabeled minigastrin peptides for diagnosis and therapy of NETs”. He has published about 100 research articles in international reputed journals and 7 book chapters. Pakistan Institute of Nuclear Science & Technology (PINSTECH) Islamabad, Punjab Institute of Nuclear Medicine (PINM), Faisalabad and Institute of Nuclear Medicine and Radiology (INOR) Abbottabad are the main collaborating institutes.",institutionString:"Government College University",institution:{name:"Government College University, Faisalabad",country:{name:"Pakistan"}}},{id:"58390",title:"Dr.",name:"Gyula",middleName:null,surname:"Mozsik",slug:"gyula-mozsik",fullName:"Gyula Mozsik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/58390/images/system/58390.png",biography:"Gyula Mózsik MD, Ph.D., ScD (med), is an emeritus professor of Medicine at the First Department of Medicine, Univesity of Pécs, Hungary. He was head of this department from 1993 to 2003. His specializations are medicine, gastroenterology, clinical pharmacology, clinical nutrition, and dietetics. His research fields are biochemical pharmacological examinations in the human gastrointestinal (GI) mucosa, mechanisms of retinoids, drugs, capsaicin-sensitive afferent nerves, and innovative pharmacological, pharmaceutical, and nutritional (dietary) research in humans. He has published about 360 peer-reviewed papers, 197 book chapters, 692 abstracts, 19 monographs, and has edited 37 books. He has given about 1120 regular and review lectures. He has organized thirty-eight national and international congresses and symposia. He is the founder of the International Conference on Ulcer Research (ICUR); International Union of Pharmacology, Gastrointestinal Section (IUPHAR-GI); Brain-Gut Society symposiums, and gastrointestinal cytoprotective symposiums. He received the Andre Robert Award from IUPHAR-GI in 2014. Fifteen of his students have been appointed as full professors in Egypt, Cuba, and Hungary.",institutionString:"University of Pécs",institution:{name:"University of Pecs",country:{name:"Hungary"}}},{id:"277367",title:"M.Sc.",name:"Daniel",middleName:"Martin",surname:"Márquez López",slug:"daniel-marquez-lopez",fullName:"Daniel Márquez López",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/277367/images/7909_n.jpg",biography:"Msc Daniel Martin Márquez López has a bachelor degree in Industrial Chemical Engineering, a Master of science degree in the same área and he is a PhD candidate for the Instituto Politécnico Nacional. His Works are realted to the Green chemistry field, biolubricants, biodiesel, transesterification reactions for biodiesel production and the manipulation of oils for therapeutic purposes.",institutionString:null,institution:{name:"Instituto Politécnico Nacional",country:{name:"Mexico"}}},{id:"196544",title:"Prof.",name:"Angel",middleName:null,surname:"Catala",slug:"angel-catala",fullName:"Angel Catala",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/196544/images/system/196544.jpg",biography:"Angel Catalá studied chemistry at Universidad Nacional de La Plata, Argentina, where he received a Ph.D. in Chemistry (Biological Branch) in 1965. From 1964 to 1974, he worked as an Assistant in Biochemistry at the School of Medicine at the same university. From 1974 to 1976, he was a fellow of the National Institutes of Health (NIH) at the University of Connecticut, Health Center, USA. From 1985 to 2004, he served as a Full Professor of Biochemistry at the Universidad Nacional de La Plata. He is a member of the National Research Council (CONICET), Argentina, and the Argentine Society for Biochemistry and Molecular Biology (SAIB). His laboratory has been interested for many years in the lipid peroxidation of biological membranes from various tissues and different species. Dr. Catalá has directed twelve doctoral theses, published more than 100 papers in peer-reviewed journals, several chapters in books, and edited twelve books. He received awards at the 40th International Conference Biochemistry of Lipids 1999 in Dijon, France. He is the winner of the Bimbo Pan-American Nutrition, Food Science and Technology Award 2006 and 2012, South America, Human Nutrition, Professional Category. In 2006, he won the Bernardo Houssay award in pharmacology, in recognition of his meritorious works of research. Dr. Catalá belongs to the editorial board of several journals including Journal of Lipids; International Review of Biophysical Chemistry; Frontiers in Membrane Physiology and Biophysics; World Journal of Experimental Medicine and Biochemistry Research International; World Journal of Biological Chemistry, Diabetes, and the Pancreas; International Journal of Chronic Diseases & Therapy; and International Journal of Nutrition. He is the co-editor of The Open Biology Journal and associate editor for Oxidative Medicine and Cellular Longevity.",institutionString:"Universidad Nacional de La Plata",institution:{name:"National University of La Plata",country:{name:"Argentina"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",biography:"Francisco Javier Martín-Romero (Javier) is a Professor of Biochemistry and Molecular Biology at the University of Extremadura, Spain. He is also a group leader at the Biomarkers Institute of Molecular Pathology. Javier received his Ph.D. in 1998 in Biochemistry and Biophysics. At the National Cancer Institute (National Institute of Health, Bethesda, MD) he worked as a research associate on the molecular biology of selenium and its role in health and disease. After postdoctoral collaborations with Carlos Gutierrez-Merino (University of Extremadura, Spain) and Dario Alessi (University of Dundee, UK), he established his own laboratory in 2008. The interest of Javier's lab is the study of cell signaling with a special focus on Ca2+ signaling, and how Ca2+ transport modulates the cytoskeleton, migration, differentiation, cell death, etc. He is especially interested in the study of Ca2+ channels, and the role of STIM1 in the initiation of pathological events.",institutionString:null,institution:{name:"University of Extremadura",country:{name:"Spain"}}},{id:"217323",title:"Prof.",name:"Guang-Jer",middleName:null,surname:"Wu",slug:"guang-jer-wu",fullName:"Guang-Jer Wu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/217323/images/8027_n.jpg",biography:null,institutionString:null,institution:null},{id:"148546",title:"Dr.",name:"Norma Francenia",middleName:null,surname:"Santos-Sánchez",slug:"norma-francenia-santos-sanchez",fullName:"Norma Francenia Santos-Sánchez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/148546/images/4640_n.jpg",biography:null,institutionString:null,institution:null},{id:"272889",title:"Dr.",name:"Narendra",middleName:null,surname:"Maddu",slug:"narendra-maddu",fullName:"Narendra Maddu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272889/images/10758_n.jpg",biography:null,institutionString:null,institution:null},{id:"242491",title:"Prof.",name:"Angelica",middleName:null,surname:"Rueda",slug:"angelica-rueda",fullName:"Angelica Rueda",position:"Investigador Cinvestav 3B",profilePictureURL:"https://mts.intechopen.com/storage/users/242491/images/6765_n.jpg",biography:null,institutionString:null,institution:null},{id:"88631",title:"Dr.",name:"Ivan",middleName:null,surname:"Petyaev",slug:"ivan-petyaev",fullName:"Ivan Petyaev",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Lycotec (United Kingdom)",country:{name:"United Kingdom"}}},{id:"423869",title:"Ms.",name:"Smita",middleName:null,surname:"Rai",slug:"smita-rai",fullName:"Smita Rai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424024",title:"Prof.",name:"Swati",middleName:null,surname:"Sharma",slug:"swati-sharma",fullName:"Swati Sharma",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"439112",title:"MSc.",name:"Touseef",middleName:null,surname:"Fatima",slug:"touseef-fatima",fullName:"Touseef Fatima",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Integral University",country:{name:"India"}}},{id:"424836",title:"Dr.",name:"Orsolya",middleName:null,surname:"Borsai",slug:"orsolya-borsai",fullName:"Orsolya Borsai",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca",country:{name:"Romania"}}},{id:"422262",title:"Ph.D.",name:"Paola Andrea",middleName:null,surname:"Palmeros-Suárez",slug:"paola-andrea-palmeros-suarez",fullName:"Paola Andrea Palmeros-Suárez",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Guadalajara",country:{name:"Mexico"}}}]}},subseries:{item:{id:"5",type:"subseries",title:"Parasitic Infectious Diseases",keywords:"Blood Borne Parasites, Intestinal Parasites, Protozoa, Helminths, Arthropods, Water Born Parasites, Epidemiology, Molecular Biology, Systematics, Genomics, Proteomics, Ecology",scope:"Parasitic diseases have evolved alongside their human hosts. In many cases, these diseases have adapted so well that they have developed efficient resilience methods in the human host and can live in the host for years. Others, particularly some blood parasites, can cause very acute diseases and are responsible for millions of deaths yearly. Many parasitic diseases are classified as neglected tropical diseases because they have received minimal funding over recent years and, in many cases, are under-reported despite the critical role they play in morbidity and mortality among human and animal hosts. The current topic, Parasitic Infectious Diseases, in the Infectious Diseases Series aims to publish studies on the systematics, epidemiology, molecular biology, genomics, pathogenesis, genetics, and clinical significance of parasitic diseases from blood borne to intestinal parasites as well as zoonotic parasites. We hope to cover all aspects of parasitic diseases to provide current and relevant research data on these very important diseases. In the current atmosphere of the Coronavirus pandemic, communities around the world, particularly those in different underdeveloped areas, are faced with the growing challenges of the high burden of parasitic diseases. At the same time, they are faced with the Covid-19 pandemic leading to what some authors have called potential syndemics that might worsen the outcome of such infections. Therefore, it is important to conduct studies that examine parasitic infections in the context of the coronavirus pandemic for the benefit of all communities to help foster more informed decisions for the betterment of human and animal health.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/5.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11401,editor:{id:"67907",title:"Dr.",name:"Amidou",middleName:null,surname:"Samie",slug:"amidou-samie",fullName:"Amidou Samie",profilePictureURL:"https://mts.intechopen.com/storage/users/67907/images/system/67907.jpg",biography:"Dr. Amidou Samie is an Associate Professor of Microbiology at the University of Venda, in South Africa, where he graduated for his PhD in May 2008. He joined the Department of Microbiology the same year and has been giving lectures on topics covering parasitology, immunology, molecular biology and industrial microbiology. He is currently a rated researcher by the National Research Foundation of South Africa at category C2. He has published widely in the field of infectious diseases and has overseen several MSc’s and PhDs. His research activities mostly cover topics on infectious diseases from epidemiology to control. His particular interest lies in the study of intestinal protozoan parasites and opportunistic infections among HIV patients as well as the potential impact of childhood diarrhoea on growth and child development. He also conducts research on water-borne diseases and water quality and is involved in the evaluation of point-of-use water treatment technologies using silver and copper nanoparticles in collaboration with the University of Virginia, USA. He also studies the use of medicinal plants for the control of infectious diseases as well as antimicrobial drug resistance.",institutionString:null,institution:{name:"University of Venda",institutionURL:null,country:{name:"South Africa"}}},editorTwo:null,editorThree:null,series:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188"},editorialBoard:[{id:"188881",title:"Dr.",name:"Fernando José",middleName:null,surname:"Andrade-Narváez",slug:"fernando-jose-andrade-narvaez",fullName:"Fernando José Andrade-Narváez",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRIV7QAO/Profile_Picture_1628834308121",institutionString:null,institution:{name:"Autonomous University of Yucatán",institutionURL:null,country:{name:"Mexico"}}},{id:"269120",title:"Dr.",name:"Rajeev",middleName:"K.",surname:"Tyagi",slug:"rajeev-tyagi",fullName:"Rajeev Tyagi",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRaBqQAK/Profile_Picture_1644331884726",institutionString:"CSIR - Institute of Microbial Technology, India",institution:null},{id:"336849",title:"Prof.",name:"Ricardo",middleName:null,surname:"Izurieta",slug:"ricardo-izurieta",fullName:"Ricardo Izurieta",profilePictureURL:"https://mts.intechopen.com/storage/users/293169/images/system/293169.png",institutionString:null,institution:{name:"University of South Florida",institutionURL:null,country:{name:"United States of America"}}}]},onlineFirstChapters:{paginationCount:1,paginationItems:[{id:"81644",title:"Perspective Chapter: Ethics of Using Placebo Controlled Trials for Covid-19 Vaccine Development in Vulnerable Populations",doi:"10.5772/intechopen.104776",signatures:"Lesley Burgess, Jurie Jordaan and Matthew Wilson",slug:"perspective-chapter-ethics-of-using-placebo-controlled-trials-for-covid-19-vaccine-development-in-vu",totalDownloads:9,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"SARS-CoV-2 Variants - Two Years After",coverURL:"https://cdn.intechopen.com/books/images_new/11573.jpg",subseries:{id:"6",title:"Viral Infectious Diseases"}}}]},publishedBooks:{},testimonialsList:[{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}},{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/16279",hash:"",query:{},params:{id:"16279"},fullPath:"/chapters/16279",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()