These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
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This collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
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To celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
IntechOpen and Knowledge Unlatched formed a partnership to support researchers working in engineering sciences by enabling an easier approach to publishing Open Access content. Using the Knowledge Unlatched crowdfunding model to raise the publishing costs through libraries around the world, Open Access Publishing Fee (OAPF) was not required from the authors.
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Initially, the partnership supported engineering research, but it soon grew to include physical and life sciences, attracting more researchers to the advantages of Open Access publishing.
\n\n\n\n
These books synthesize perspectives of renowned scientists from the world’s most prestigious institutions - from Fukushima Renewable Energy Institute in Japan to Stanford University in the United States, including Columbia University (US), University of Sidney (AU), University of Miami (USA), Cardiff University (UK), and many others.
\n\n
This collaboration embodied the true essence of Open Access by simplifying the approach to OA publishing for Academic editors and authors who contributed their research and allowed the new research to be made available free and open to anyone anywhere in the world.
\n\n
To celebrate the 50 books published, we have gathered them at one location - just one click away, so that you can easily browse the subjects of your interest, download the content directly, share it or read online.
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"8545",leadTitle:null,fullTitle:"Animal Reproduction in Veterinary Medicine",title:"Animal Reproduction in Veterinary Medicine",subtitle:null,reviewType:"peer-reviewed",abstract:"Despite efforts to control udder health in cattle, are the causes of mastitis are on the rise. Although at first glance the birth process seems normal in domestic pigs, what could be the problem? What are the clinical aspects of the oestrus cycle and pregnancy endocrinology in mares? What is Lidia cattle breeding and clinic? Does calf gender affect milk yield? Do insecticides reduce fertility? Could boar pheromones be an option to stimulate sow reproduction? Animal Reproduction in Veterinary Medicine is a book with the answers to such questions. It includes ‘Induction and Synchronization of Estrus’, which describes the protocol principles and tools. The practical approach this book takes will help students, farmers, veterinarians and academics to build an understanding of the concepts and procedures required to answer real questions by comprehending the basic function of real clinic data. Humans often endure results from the misunderstanding that to be doing well, they should make each thing themselves.",isbn:"978-1-83881-937-8",printIsbn:"978-1-83881-936-1",pdfIsbn:"978-1-83881-938-5",doi:"10.5772/intechopen.78921",price:119,priceEur:129,priceUsd:155,slug:"animal-reproduction-in-veterinary-medicine",numberOfPages:258,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"13aaddf5fdbbc78387e77a7da2388bf6",bookSignature:"Faruk Aral, Rita Payan-Carreira and Miguel Quaresma",publishedDate:"January 20th 2021",coverURL:"https://cdn.intechopen.com/books/images_new/8545.jpg",numberOfDownloads:10229,numberOfWosCitations:12,numberOfCrossrefCitations:13,numberOfCrossrefCitationsByBook:0,numberOfDimensionsCitations:23,numberOfDimensionsCitationsByBook:1,hasAltmetrics:1,numberOfTotalCitations:48,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"August 20th 2019",dateEndSecondStepPublish:"February 13th 2020",dateEndThirdStepPublish:"April 13th 2020",dateEndFourthStepPublish:"July 2nd 2020",dateEndFifthStepPublish:"August 31st 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6",editedByType:"Edited by",kuFlag:!1,featuredMarkup:null,editors:[{id:"25600",title:"Prof.",name:"Faruk",middleName:null,surname:"Aral",slug:"faruk-aral",fullName:"Faruk Aral",profilePictureURL:"https://mts.intechopen.com/storage/users/25600/images/system/25600.jpg",biography:"Prof. Dr. Faruk Aral has been a researcher at the Harran and Niğde University for more than 22 years. His practice is not limited to university work. He has worked in several institutions of animal research in public and animal feed manufacturers as well as in the private sector from 1988-1994. He earned his Veterinary Medicine degree from the University of Ankara in 1987, and received his Ph.D. from the Department of Reproduction and Artificial Insemination at the same university (1994). In 2000, he served as Assistant Professor and Associate Professor at the Harran University and in 2010 moved to Nigde University. His research interests are reproduction and artificial insemination, andrology, spermatological studies, biotechnology and toxicology in animal reproduction in livestock animals, fish and bees.",institutionString:"Independent Researcher",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"2",totalChapterViews:"0",totalEditedBooks:"2",institution:{name:"Harran University",institutionURL:null,country:{name:"Turkey"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:{id:"38652",title:"Prof.",name:"Rita",middleName:null,surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRiFPQA0/Profile_Picture_1614601496313",biography:"Rita Payan Carreira earned her Veterinary Degree from the Faculty of Veterinary Medicine in Lisbon, Portugal, in 1985. She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. She is also a frequent referee for various journals.",institutionString:null,position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"6",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"University of Évora",institutionURL:null,country:{name:"Portugal"}}},coeditorTwo:{id:"309250",title:"Dr.",name:"Miguel",middleName:null,surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma",profilePictureURL:"https://mts.intechopen.com/storage/users/309250/images/9059_n.jpg",biography:"Miguel Nuno Pinheiro Quaresma was born on May 26, 1974 in Dili, Timor Island. He is married with two children: a boy and a girl, and he is a resident in Vila Real, Portugal. He graduated in Veterinary Medicine in August 1998 and obtained his Ph.D. degree in Veterinary Sciences -Clinical Area in February 2015, both from the University of Trás-os-Montes e Alto Douro. He is currently enrolled in the Alternative Residency of the European College of Animal Reproduction. He works as a Senior Clinician at the Veterinary Teaching Hospital of UTAD (HVUTAD) with a role in clinical activity in the area of livestock and equine species as well as to support teaching and research in related areas. He teaches as an Invited Professor in Reproduction Medicine I and II of the Master\\'s in Veterinary Medicine degree at UTAD. Currently, he holds the position of Chairman of the Portuguese Buiatrics Association. He is a member of the Consultive Group on Production Animals of the OMV. He has 19 publications in indexed international journals (ISIS), as well as over 60 publications and oral presentations in both Portuguese and international journals and congresses.",institutionString:"University of Trás-os-Montes and Alto Douro",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:{name:"University of Trás-os-Montes and Alto Douro",institutionURL:null,country:{name:"Portugal"}}},coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"1379",title:"Theriogenology",slug:"animal-science-theriogenology"}],chapters:[{id:"70381",title:"Physiological and Clinical Aspects of the Endocrinology of the Estrous Cycle and Pregnancy in Mares",doi:"10.5772/intechopen.90387",slug:"physiological-and-clinical-aspects-of-the-endocrinology-of-the-estrous-cycle-and-pregnancy-in-mares",totalDownloads:701,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"The use of advanced reproductive endocrinology can generate important economic benefits for equine breeding farms. Pregnancy in the mare involves considerable endocrine changes, which can be explained in part by the development of different structures such as embryonic vesicles, primary and secondary CL, endometrial cups and development of fetoplacental units. Both the pregnant mare and the fetus adapt to this development with unique mechanisms, such as alterations in the maternal endocrine metabolism and hormonal feedback. Since the ability to produce a viable foal is critical for the broodmare, the maintenance of the gestation implies almost a year of physiological effort. Therefore, the joint knowledge of basic reproductive science and current clinical endocrinology allows veterinarians and breeders to be better positioned to achieve their objectives. This chapter reviews normal and abnormal endocrine patterns during the equine estrual cycle, pregnancy. We also consider hormonal evaluation related to placentitis, abortions, recurrent pregnancy loss, and premature deliveries. Also, several aspects associated with endocrinological control of the reproductive cycle, ovulation, parturition, high-risk mare, and hormone supplementation will be developed.",signatures:"Katy Satué and Juan Carlos Gardon",downloadPdfUrl:"/chapter/pdf-download/70381",previewPdfUrl:"/chapter/pdf-preview/70381",authors:[{id:"125292",title:"Dr.",name:"Katy",surname:"Satué Ambrojo",slug:"katy-satue-ambrojo",fullName:"Katy Satué Ambrojo"},{id:"251314",title:"Dr.",name:"Juan Carlos",surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón"}],corrections:null},{id:"71105",title:"Understanding Sow Sexual Behavior and the Application of the Boar Pheromone to Stimulate Sow Reproduction",doi:"10.5772/intechopen.90774",slug:"understanding-sow-sexual-behavior-and-the-application-of-the-boar-pheromone-to-stimulate-sow-reprodu",totalDownloads:1171,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:1,abstract:"In this chapter, we review the sexual behavior of domestic pigs, and the visible or measurable anatomical features of the pig that will contribute to detecting sows in estrus. We also summarize olfactory organs, and the effects of a sexual pheromone on pig’s biology and sow reproductive performance. We discuss the role of a live boar in the heat detection where the female is in breeding crates. However, there is an increasing interest in being able to breed sows without a boar present. Farm workers must be trained on the fine points of estrus detection so that they can work in a safe and productive setting. After a review of olfactory biology of the pig, the chapter explains how new pheromonal technology, such as BOARBETTER®, aids in the process of heat detection with or without a live boar. To achieve reproductive success, the persons breeding must assimilate all fine points of pig sexual behavior and possess a clear understanding of what they should be looking for in each sow they expect to breed.",signatures:"John J. McGlone, Edgar O. Aviles-Rosa, Courtney Archer, Meyer M. Wilson, Karlee D. Jones, Elaina M. Matthews, Amanda A. Gonzalez and Erica Reyes",downloadPdfUrl:"/chapter/pdf-download/71105",previewPdfUrl:"/chapter/pdf-preview/71105",authors:[{id:"311962",title:"Prof.",name:"John",surname:"McGlone",slug:"john-mcglone",fullName:"John McGlone"},{id:"315592",title:"Dr.",name:"Edgar",surname:"Aviles-Rosa",slug:"edgar-aviles-rosa",fullName:"Edgar Aviles-Rosa"},{id:"315595",title:"B.Sc.",name:"Courtney",surname:"Archer",slug:"courtney-archer",fullName:"Courtney Archer"},{id:"315596",title:"Ms.",name:"Meyer",surname:"Wilson",slug:"meyer-wilson",fullName:"Meyer Wilson"},{id:"315597",title:"Ms.",name:"Karlee",surname:"Jones",slug:"karlee-jones",fullName:"Karlee Jones"},{id:"315598",title:"Ms.",name:"Elaina",surname:"Mathews",slug:"elaina-mathews",fullName:"Elaina Mathews"},{id:"315599",title:"Ms.",name:"Erica",surname:"Reyes",slug:"erica-reyes",fullName:"Erica Reyes"},{id:"315600",title:"MSc.",name:"Amanda",surname:"Gonzalez",slug:"amanda-gonzalez",fullName:"Amanda Gonzalez"}],corrections:null},{id:"73979",title:"Troubled Process of Parturition of the Domestic Pig",doi:"10.5772/intechopen.94547",slug:"troubled-process-of-parturition-of-the-domestic-pig",totalDownloads:546,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"Over the past three decades, efficient breeding and management have almost doubled the litter size of sows. Simultaneously, duration of farrowing has increased markedly. The expulsion phase of parturition in the hyper prolific sow is now 3 to 5 times longer than it was in the early 1990s. There has also been a constant downward trend in piglet birth weight, along with a similar trend in colostrum intake, which is an important risk factor for piglet mortality. Together with these trends, an increase in farrowing complications, such as postpartum dysgalactia and retention of placenta, has been reported. This paper investigates group housing of sows during gestation, farrowing and lactation, focusing on management strategies of the sow. In short, the sow needs to be given space and enrichment materials for adequate expression of nest-building behavior. Maternal characteristics may be utilized to improve the success rate of reproductive management during farrowing and early lactation. The lower piglet birth weight and compromised immunity of newborn piglets warrant investigation in the search for novel management tools. Robust breeds with somewhat lower litter size, but improved resilience and increased birth weight may be needed in the near future.",signatures:"Claudio Oliviero and Olli Peltoniemi",downloadPdfUrl:"/chapter/pdf-download/73979",previewPdfUrl:"/chapter/pdf-preview/73979",authors:[{id:"45491",title:"Prof.",name:"Olli",surname:"Peltoniemi",slug:"olli-peltoniemi",fullName:"Olli Peltoniemi"},{id:"45504",title:"Dr.",name:"Claudio",surname:"Oliviero",slug:"claudio-oliviero",fullName:"Claudio Oliviero"}],corrections:null},{id:"73371",title:"Reproduction in Small Ruminants (Goats)",doi:"10.5772/intechopen.93481",slug:"reproduction-in-small-ruminants-goats-",totalDownloads:609,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The exploitation of small ruminants (goat and sheep) has always been linked to the development of human civilizations, where they have mainly fed on their derived products such as milk and meat. Currently, the sheep population is around 1 billion head concentrated above 50% in three countries, China, Australia, and New Zealand, contrary to goats with around 720 million heads, distributed mainly in Asia, Africa, and South America. Both species have similar characteristics in some anatomical aspects (a pair of nipples), gestation period (150 days), and presence of seasonal anestrus, differing in terms of magnitude and depth and presence of the male effect. However, they are completely different in feeding habits, nutrient needs, and grazing systems, with differences in terms of the female’s reproductive tract, among other characteristics. Currently, the study of reproduction has intensified over the years in the goats and its counterpart that is the buck. Therefore, in the following topics, the importance of global reproduction of the goat will be discussed, considering that progress has been made today in the application of third generation reproductive techniques and that today they are already consolidated and developed in the bovine species.",signatures:"Fernando Sánchez Dávila and Gerardo Pérez Muñoz",downloadPdfUrl:"/chapter/pdf-download/73371",previewPdfUrl:"/chapter/pdf-preview/73371",authors:[{id:"201830",title:"Dr.",name:"Fernando",surname:"Davila",slug:"fernando-davila",fullName:"Fernando Davila"},{id:"327566",title:"MSc.",name:"Gerardo",surname:"Perez-Muñoz",slug:"gerardo-perez-munoz",fullName:"Gerardo Perez-Muñoz"}],corrections:null},{id:"71297",title:"Tools and Protocols for Managing Hyperprolific Sows at Parturition: Optimizing Piglet Survival and Sows’ Reproductive Health",doi:"10.5772/intechopen.91337",slug:"tools-and-protocols-for-managing-hyperprolific-sows-at-parturition-optimizing-piglet-survival-and-so",totalDownloads:953,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Genetic selection for higher prolificacy is one of the major causes for a decrease in piglet survival and reproductive health of the sow. Large litters increase farrowing duration and decrease piglet birth weight and therefore have an impact on piglet vitality, colostrum uptake, and piglet survival. Large litters also increase the incidence of postpartum dysgalactia syndrome (PDS) and the probability of the sow to be removed from the herd because of reproductive failure. Therefore, hyper-prolificacy challenges the performance of the sow in terms of parturition, colostrum production, neonatal survival, and fertility. In this review, we discuss the tools and protocols for management of parturition, colostrum, and sows’ reproductive health. We provide checklists for the prevention of birth complications and PDS as well as for improvement of mammary gland development and colostrum production.",signatures:"Stefan Björkman and Alexander Grahofer",downloadPdfUrl:"/chapter/pdf-download/71297",previewPdfUrl:"/chapter/pdf-preview/71297",authors:[{id:"311550",title:"Ph.D.",name:"Stefan",surname:"Björkman",slug:"stefan-bjorkman",fullName:"Stefan Björkman"},{id:"317576",title:"Dr.",name:"Alexander",surname:"Grahofer",slug:"alexander-grahofer",fullName:"Alexander Grahofer"}],corrections:null},{id:"72063",title:"The Lidia Breed: Management and Medicine",doi:"10.5772/intechopen.92008",slug:"the-lidia-breed-management-and-medicine",totalDownloads:745,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:1,abstract:"The Lidia breed, originally from Spain, constitutes an important livestock sector in Spain and Portugal. These animals are also bred in southern France and in several countries of South America (Mexico, Colombia, Peru, Ecuador, and Venezuela). The clinical management of this breed is different from other cattle breeds; therefore, it is essential to analyze the characteristics of the farm organization, the selection scheme, the reproduction, feeding, and healthcare management. The sector is currently evolving with high progress in feeding, selection, and assisted reproduction. Not surprisingly, there are several problems that the farmers and veterinarians must overcome such as health problems, the falling syndrome, and the danger of extinction of certain genetic lines.",signatures:"Juan Manuel Lomillos and Marta Elena Alonso",downloadPdfUrl:"/chapter/pdf-download/72063",previewPdfUrl:"/chapter/pdf-preview/72063",authors:[{id:"312934",title:"Ph.D.",name:"Juan Manuel",surname:"Lomillos Perez",slug:"juan-manuel-lomillos-perez",fullName:"Juan Manuel Lomillos Perez"},{id:"316830",title:"Dr.",name:"Marta Elena",surname:"Alonso",slug:"marta-elena-alonso",fullName:"Marta Elena Alonso"}],corrections:null},{id:"70760",title:"Induction and Synchronization of Estrus",doi:"10.5772/intechopen.90769",slug:"induction-and-synchronization-of-estrus",totalDownloads:1720,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Estrus cycle is a rhythmic change that occur in the reproductive system of females starting from one estrus phase to another. The normal duration of estrus cycle is 21 days in cow, sow, and mare, 17 days in ewe, and 20 days in doe. The species which exhibit a single estrus cycle are known as monstrous and species which come into estrus twice or more are termed polyestrous animals. Among them some species have estrus cycles in a particular season and defined as seasonal polyestrous. It includes goats, sheep, and horses. On the other hand, cattle undergo estrus throughout the year. The estrus inducers can grossly be divided into two parts, that is, non-hormonal and hormonal. Non-hormonal treatments include plant-derived heat inducers, mineral supplementation, uterine and ovarian massage, and use of Lugol’s iodine. The hormones that are used in estrus induction are estrogen, progesterone, GnRH, prostaglandin, insulin, and anti-prolactin-based treatment. Synchronization can shorten the breeding period to less than 5 days, instead of females being bred over a 21-day period, depending on the treatment regimen. The combination of GnRH with the prostaglandin F2α (PGF2α)- and progesterone-based synchronization program has shown a novel direction in the estrus synchronization of cattle with the follicular development manipulation.",signatures:"Prasanna Pal and Mohammad Rayees Dar",downloadPdfUrl:"/chapter/pdf-download/70760",previewPdfUrl:"/chapter/pdf-preview/70760",authors:[{id:"299126",title:"Dr.",name:"Mohammad Rayees",surname:"Dar",slug:"mohammad-rayees-dar",fullName:"Mohammad Rayees Dar"},{id:"311663",title:"Dr.",name:"Prasanna",surname:"Pal",slug:"prasanna-pal",fullName:"Prasanna Pal"}],corrections:null},{id:"73116",title:"Bovine Mastitis: Part I",doi:"10.5772/intechopen.93483",slug:"bovine-mastitis-part-i",totalDownloads:802,totalCrossrefCites:2,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Bovine mastitis is one of the most important bacterial diseases of dairy cattle throughout the world. Mastitis is responsible for great economic losses to the dairy producer and to the milk processing industry resulting from reduced milk production, alterations in milk composition, discarded milk, increased replacement costs, extra labor, treatment costs, and veterinary services. Economic losses due to bovine mastitis are estimated to be $2 billion in the United States, $400 million in Canada (Canadian Bovine Mastitis and Milk Quality Research Network-CBMQRN) and $130 million in Australia per year. Many factors can influence the development of mastitis; however, inflammation of the mammary gland is usually a consequence of adhesion, invasion, and colonization of the mammary gland by one or more mastitis pathogens such as Staphylococcus aureus, Streptococcus uberis, and Escherichia coli.",signatures:"Oudessa Kerro Dego",downloadPdfUrl:"/chapter/pdf-download/73116",previewPdfUrl:"/chapter/pdf-preview/73116",authors:[{id:"283019",title:"Dr.",name:"Oudessa",surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego"}],corrections:null},{id:"73077",title:"Control and Prevention of Mastitis: Part Two",doi:"10.5772/intechopen.93484",slug:"control-and-prevention-of-mastitis-part-two",totalDownloads:815,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Current mastitis control measures are based upon good milking time hygiene; use of properly functioning milking machines; maintaining clean, dry, comfortable housing areas; segregation and culling of persistently infected animals; dry cow antibiotic therapy; proper identification and treatment of cows with clinical mastitis during lactation; establishing udder health goals; good record-keeping; regular monitoring of udder health status and periodic review of mastitis control program. Despite significant effect of these control measures when fully adopted, especially on contagious mastitis pathogens, these measures are not equally adopted by all farmers, and mastitis continues to be the most common and costly disease of dairy cattle throughout the world.",signatures:"Oudessa Kerro Dego",downloadPdfUrl:"/chapter/pdf-download/73077",previewPdfUrl:"/chapter/pdf-preview/73077",authors:[{id:"283019",title:"Dr.",name:"Oudessa",surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego"}],corrections:null},{id:"73658",title:"Current Status of Antimicrobial Resistance and Prospect for New Vaccines against Major Bacterial Bovine Mastitis Pathogens",doi:"10.5772/intechopen.94227",slug:"current-status-of-antimicrobial-resistance-and-prospect-for-new-vaccines-against-major-bacterial-bov",totalDownloads:838,totalCrossrefCites:2,totalDimensionsCites:3,hasAltmetrics:0,abstract:"Economic losses due to bovine mastitis is estimated to be $2 billion in the United States alone. Antimicrobials are used extensively in dairy farms for prevention and treatment of mastitis and other diseases of dairy cattle. The use of antimicrobials for treatment and prevention of diseases of dairy cattle needs to be prudent to slow down the development, persistence, and spread of antimicrobial-resistant bacteria from dairy farms to humans, animals, and farm environments. Because of public health and food safety concerns regarding antimicrobial resistance and antimicrobial residues in meat and milk, alternative approaches for disease control are required. These include vaccines, improvements in housing, management practices that reduce the likelihood and effect of infectious diseases, management systems and feed formulation, studies to gain a better understanding of animal behavior, and the development of more probiotics and competitive exclusion products. Monitoring antimicrobial resistance patterns of bacterial isolates from cases of mastitis and dairy farm environments is important for treatment decisions and proper design of antimicrobial-resistance mitigation measures. It also helps to determine emergence, persistence, and potential risk of the spread of antimicrobial-resistant bacteria and resistome from these reservoirs in dairy farms to humans, animals, and farm environments.",signatures:"Oudessa Kerro Dego",downloadPdfUrl:"/chapter/pdf-download/73658",previewPdfUrl:"/chapter/pdf-preview/73658",authors:[{id:"283019",title:"Dr.",name:"Oudessa",surname:"Kerro Dego",slug:"oudessa-kerro-dego",fullName:"Oudessa Kerro Dego"}],corrections:null},{id:"73504",title:"Calf-Sex Influence in Bovine Milk Production",doi:"10.5772/intechopen.93966",slug:"calf-sex-influence-in-bovine-milk-production",totalDownloads:570,totalCrossrefCites:0,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The main source of incomes in a dairy farm is milk sales, and any factor altering the production affects the farmers’ income significantly. According to the Trivers-Willard hypothesis, if the cows’ systems are generally good and offer competitive conditions, they produce more milk for bull calves. They also suggest that cows in a worse condition or of a genetically diverging strain invest more milk in heifer calves. The existence of a sex-bias in cows’ milk production remains controversial even if it would open new insights on the economic impacts of using sex-sorted semen to enhance farm productivity. Sex-biased milk production in cows can vary, favoring one sex or the other and, sometimes, none. It seems to favor females in intensive production systems, while in other less intensive systems, this effect seems to disappear. This chapter intends to address available evidence on the sex-biased cows’ milk production and discuss why further research forecasting this issue is needed, including other cattle populations and correlating the investment strategy with an animal welfare index. Besides, other factors, such as different housing and feedings, can impact the calf-sex milk production bias through pathways still to be understood.",signatures:"Miguel Quaresma and R. Payan-Carreira",downloadPdfUrl:"/chapter/pdf-download/73504",previewPdfUrl:"/chapter/pdf-preview/73504",authors:[{id:"38652",title:"Prof.",name:"Rita",surname:"Payan-Carreira",slug:"rita-payan-carreira",fullName:"Rita Payan-Carreira"},{id:"309250",title:"Dr.",name:"Miguel",surname:"Quaresma",slug:"miguel-quaresma",fullName:"Miguel Quaresma"}],corrections:[{id:"74026",title:"Corrigendum to: Calf-Sex Influence in Bovine Milk Production",doi:null,slug:"corrigendum-to-calf-sex-influence-in-bovine-milk-production",totalDownloads:null,totalCrossrefCites:null,correctionPdfUrl:null}]},{id:"72504",title:"Reproductive Toxicity of Insecticides",doi:"10.5772/intechopen.92890",slug:"reproductive-toxicity-of-insecticides",totalDownloads:759,totalCrossrefCites:1,totalDimensionsCites:2,hasAltmetrics:0,abstract:"Pesticides include several classes such as insecticides, herbicides, fungicides, and have widespread usage in agriculture. Different type of pesticides and their combinations affect dairy animals through their lifetime and the livestock industry. Under chronic exposure conditions, hormonal and cellular systems of animals, which play a role in reproduction, are affected dramatically. Some of the insecticides act as endocrine disruptors and impair reproductive hormone metabolic pathways via the hypothalamic-pituitary-gonadal (HPG) axis. Additionally, insecticides could have harmful effects on reproductive organs that may cause infertility. 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She obtained her Ph.D. in Veterinary Sciences from the University of Trás-os-Montes e Alto Douro, Portugal. After almost 32 years of teaching at the University of Trás-os-Montes and Alto Douro, she recently moved to the University of Évora, Department of Veterinary Medicine, where she teaches in the field of Animal Reproduction and Clinics. Her primary research areas include the molecular markers of the endometrial cycle and the embryo–maternal interaction, including oxidative stress and the reproductive physiology and disorders of sexual development, besides the molecular determinants of male and female fertility. She often supervises students preparing their master's or doctoral theses. 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\n\t\t\t
1. Introduction
\n\t\t\t
Model predictive control, MPC, has many interesting features for its application to mobile robot control. It is a more effective advanced control technique, as compared to the standard PID control, and has made a significant impact on industrial process control (Maciejowski, 2002). MPC usually contains the following three ideas:
\n\t\t\t
The model of the process is used to predict the future outputs along a horizon time.
An index of performance is optimized by a control sequence computation.
It is used a receding horizon idea, so at each instant of time the horizon is moved towards the future. It involves the application of the first control signal of the sequence computed at each step.
\n\t\t\t
The majority of the research developed using MPC techniques and their application to WMR (wheeled mobile robots) is based on the fact that the reference trajectory is known beforehand (Klancar & Skrjanc, 2007). The use of mobile robot kinematics to predict future system outputs has been proposed in most of the different research developed (Kühne et al., 2005; Gupta et al., 2005). The use of kinematics have to include velocity and acceleration constraints to prevent WMR of unfeasible trajectory-tracking objectives. MPC applicability to vehicle guidance has been mainly addressed at path-tracking using different on-field fixed trajectories and using kinematics models. However, when dynamic environments or obstacle avoidance policies are considered, the navigation path planning must be constrained to the robot neighborhood where reactive behaviors are expected (Fox et al., 1997; Ögren & Leonard, 2005). Due to the unknown environment uncertainties, short prediction horizons have been proposed (Pacheco et al., 2008). In this context, the use of dynamic input-output models is proposed as a way to include the dynamic constraints within the system model for controller design. In order to do this, a set of dynamic models obtained from experimental robot system identification are used for predicting the horizon of available coordinates. Knowledge of different models can provide information about the dynamics of the robot, and consequently about the reactive parameters, as well as the safe stop distances. This work extends the use of on-line MPC as a suitable local path-tracking methodology by using a set of linear time-varying descriptions of the system dynamics when short prediction horizons are used. In the approach presented, the trajectory is dynamically updated by giving a straight line to be tracked. In this way, the control law considers the local point to be achieved and the WMR coordinates. The cost function is formulated with parameters that involve the capacity of turning and going straight. In the case considered, the Euclidean distance between the robot and the desired trajectory can be used as a potential function. Such functions are CLF (control Lyapunov function), and consequently asymptotic stability with respect to the desired trajectory can be achieved. On-line MPC is tested by using the available WMR. A set of trajectories is used for analyzing the path-tracking performance. In this context, the different parameter weights of the cost function are studied. The experiments are developed by considering five different kinds of trajectories. Therefore, straight, wide left turning, less left turning, wide right turning, and less right turning are tested. Experiments are conducted by using factorial design with two levels of quantitative factors (Box et al., 2005). Studies are used as a way of inferring the weight of the different parameters used in the cost function. Factor tuning is achieved by considering aspects, such as the time taken, or trajectory deviation, within different local trajectories. Factor tuning depicts that flexible cost function as an event of the path to be followed, can improve control performance when compared with fixed cost functions. It is proposed to use local artificial potential attraction field coordinates as a way to attract WMR towards a local desired goal. Experiments are conducted by using a monocular perception system and local MPC path-tracking. On-line MPC is reported as a suitable navigation strategy for dynamics environments.
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This chapter is organized as follows: Section 1 gives a brief presentation about the aim of the present work. In the Section 2, the WMR dynamic models are presented. This section also describes the MPC formulation, algorithms and simulated results for achieving local path-tracking. Section 3 presents the MPC implemented strategies and the experimental results developed in order to adjust the cost function parameters. The use of visual data is presented as a horizon where trajectories can be planned by using MPC strategies. In this context local MPC is tested as a suitable navigation strategy. Finally, in Section 4 some conclusions are made.
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2. The control system identification and the MPC formulation
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This section introduces the necessary previous background used for obtaining the control laws that are tested in this work as a suitable methodology for performing local navigation. The WMR PRIM, available in our lab, has been used in order to test and orient the research (Pacheco et al., 2009). Fig. 1 shows the robot PRIM and sensorial and system blocs used in
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Figure 1.
a) The robot PRIM used in this work; (b) The sensorial and electronic system blocs
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the research work. The mobile robot consists of a differential driven one, with two independent wheels of 16cm diameters actuated by two DC motors. A third spherical omni-directional wheel is used to guarantee the system stability. Next subsection deals with the problem of modeling the dynamics of the WMR system. Furthermore, dynamic MPC techniques for local trajectory tracking and some simulated results are introduced in the remaining subsections. A detailed explanation of the methods introduced in this section can be found in (Pacheco et al., 2008).
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2.1. Experimental model and system identification
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The model is obtained through the approach of a set of lineal transfer functions that include the nonlinearities of the whole system. The parametric identification process is based on black box models (Norton, 1986; Ljung, 1989). The nonholonomic system dealt with in this work is considered initially to be a MIMO (multiple input multiple output) system, as shown in Fig. 2, due to the dynamic influence between two DC motors. This MIMO system is composed of a set of SISO (single input single output) subsystems with coupled connection.
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Figure 2.
The MIMO system structure
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The parameter estimation is done by using a PRBS (Pseudo Random Binary Signal) such as excitation input signal. It guarantees the correct excitation of all dynamic sensible modes of the system along the whole spectral range and thus results in an accurate precision of parameter estimation. The experiments to be realized consist in exciting the two DC motors in different (low, medium and high) ranges of speed. The ARX (auto-regressive with external input) structure has been used to identify the parameters of the system. The problem consists in finding a model that minimizes the error between the real and estimated data. By expressing the ARX equation as a lineal regression, the estimated output can be written as:
with \n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\ty\n\t\t\t\t\t\t\t\t^\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t being the estimated output vector, θ the vector of estimated parameters and φ the vector of measured input and output variables. By using the coupled system structure, the transfer function of the robot can be expressed as follows:
where Y\n\t\t\t\t\t\n\t\t\t\t\t\tR\n\t\t\t\t\t and Y\n\t\t\t\t\t\n\t\t\t\t\t\tL\n\t\t\t\t\t represent the speeds of right and left wheels, and U\n\t\t\t\t\t\n\t\t\t\t\t\tR\n\t\t\t\t\t and U\n\t\t\t\t\t\n\t\t\t\t\t\tL\n\t\t\t\t\t the corresponding speed commands, respectively. In order to know the dynamics of robot system, the matrix of transfer function should be identified. In this way, speed responses to PBRS input signals are analyzed. The filtered data, which represent the average value of five different experiments with the same input signal, are used for identification. The system is identified by using the identification toolbox “ident” of Matlab for the second order models. Table 1 shows the continuous transfer functions obtained for the three different lineal speed models.
The coupling effects should be studied as a way of obtaining a reduced-order dynamic model. It can be seen from Table 1 that the dynamics of two DC motors are different and the steady gains of coupling terms are relatively small (less than 20% of the gains of main diagonal terms). Thus, it is reasonable to neglect the coupling dynamics so as to obtain a simplified model. In order to verify the above facts from real results, a set of experiments have been done by sending a zero speed command to one motor and different non-zero speed commands to the other motor. The experimental result confirms that the coupled dynamics can be neglected. The existence of different gains in steady state is also verified experimentally. Finally, the order reduction of the system model is carried out through the analysis of pole positions by using the root locus method. It reveals the existence of a dominant pole and consequently the model order can be reduced from second order to first order. Table 2 shows the first order transfer functions obtained. Afterwards, the system models are validated through the experimental data by using the PBRS input signal.
2.2. Dynamic MPC techniques for local trajectory tracking
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The minimization of path tracking error is considered to be a challenging subject in mobile robotics. In this subsection the LMPC (local model predictive control) techniques based on the dynamics models obtained in the previous subsection are presented. The use of dynamic models avoids the use of velocity and acceleration constraints used in other MPC research based on kinematic models. Moreover, contractive constraints are proposed as a way of guaranteeing convergence towards the desired coordinates. In addition, real-time implementations are easily implemented due to the fact that short prediction horizons are used. By using LMPC, the idea of a receding horizon can deal with local on-robot sensor information. The LMPC and contractive constraint formulations as well as the algorithms and simulations implemented are introduced in the next subsections.
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2.2.1. The LMPC formulation
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The main objective of highly precise motion tracking consists in minimizing the error between the robot and the desired path. Global path-planning becomes unfeasible since the sensorial system of some robots is just local. In this way, LMPC is proposed in order to use the available local perception data in the navigation strategies. Concretely, LMPC is based on minimizing a cost function related to the objectives for generating the optimal WMR inputs. Define the cost function as follows:
The first term of (3) refers to the attainment of the local desired coordinates, X\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tld\n\t\t\t\t\t\t\n\t\t\t\t\t\t=(x\n\t\t\t\t\t\t\n\t\t\t\t\t\t\td\n\t\t\t\t\t\t\n\t\t\t\t\t\t,y\n\t\t\t\t\t\t\n\t\t\t\t\t\t\td\n\t\t\t\t\t\t), where (x\n\t\t\t\t\t\t\n\t\t\t\t\t\t\td\n\t\t\t\t\t\t\n\t\t\t\t\t\t, y\n\t\t\t\t\t\t\n\t\t\t\t\t\t\td\n\t\t\t\t\t\t) denote the desired Cartesian coordinates. X(k+n/k) represents the terminal value of the predicted output after the horizon of prediction n. The second one can be considered as an orientation term and is related to the distance between the predicted robot positions and the trajectory segment given by a straight line between the initial robot Cartesian coordinates X\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tl0\n\t\t\t\t\t\t\n\t\t\t\t\t\t=(x\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tl0\n\t\t\t\t\t\t\n\t\t\t\t\t\t, y\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tl0\n\t\t\t\t\t\t) from where the last perception was done and the desired local position, X\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tld\n\t\t\t\t\t\t, to be achieved within the perceived field of view. This line orientation is denoted by θ\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tld\n\t\t\t\t\t\t and denotes the desired orientation towards the local objective. X(k+i/k) and θ(k+i/k) (i=1,…n-1) represents the predicted Cartesian and orientation values within the prediction horizon. The third term is the predicted orientation error. The last one is related to the power signals assigned to each DC motor and are denoted as U. The parameters P, Q, R and S are weighting parameters that express the importance of each term. The control horizon is designed by the parameter m. The system constraints are also considered:
where X(k) and θ(k) denote the current WMR coordinates and orientation, X(k+n/k) and θ(k+n/k) denote the final predicted coordinates and orientation, respectively. The limitation of the input signal is taken into account in the first constraint, where G\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t0\n\t\t\t\t\t\t and G\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t1\n\t\t\t\t\t\t respectively denote the dead zone and saturation of the DC motors. The second and third terms are contractive constraints (Wang, 2007), which result in the convergence of coordinates or orientation to the objective, and should be accomplished at each control step.
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2.2.2. The algorithms and simulated results
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By using the basic ideas introduced in the previous subsection, the LMPC algorithms have the following steps:
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Read the current position
Minimize the cost function and to obtain a series of optimal input signals
Choose the first obtained input signal as the command signal.
Go back to the step 1 in the next sampling period.
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The minimization of the cost function is a nonlinear problem in which the following equation should be verified:
The use of interior point methods can solve the above problem (Nesterov et al., 1994; Boyd & Vandenberghe, 2004). Gradient descent method and complete input search can be used for obtaining the optimal input. In order to reduce the set of possibilities, when optimal solution is searched for, some constraints over the DC motor inputs are taken into account:
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The signal increment is kept fixed within the prediction horizon.
The input signals remain constant during the remaining interval of time.
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The above considerations will result in the reduction of the computation time and the smooth behavior of the robot during the prediction horizon (Maciejowski, 2002). Thus, the set of available input is reduced to one value, as it is shown in Fig. 3.
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Figure 3.
LMPC strategy with fixed increment of the input during the control horizon and constant value for the remaining time
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Both search methods perform accurate path-tracking. Optimal input search has better time performance and subinterval gradient descent method does not usually give the optimal solution. Due to these facts obtained from simulations, complete input search is selected for the on-robot experiences presented in the next section.
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The evaluation of the LMPC performance is made by using different parametric values in the proposed cost function (3). In this way, when only the desired coordinates are considered, (P=1, Q=0, R=0, S=0), the trajectory-tracking is done with the inputs that can minimize the cost function by shifting the robot position to the left. The reason can be found in Table 2, where the right motor has more gain than the left one for high speeds. This problem can be solved, (P=1, Q=1, R=0, S=0) or (P=1, Q=0, R=1, S=0) by considering either the straight-line trajectory from the point where the last perception was done to the final desired point belonging to the local field of perception or the predicted orientations. Simulated results by testing both strategies provide similar satisfactory results. Thus, the straight line path or orientation should be considered in the LMPC cost function. Fig. 4 shows a simulated result of LMPC for WMR by using the orientation error, the trajectory distance and the final desired point for the cost function optimization (P=1, Q=1, R=1, S=0). Obtained results show the need of R parameter when meaningful orientation errors are produced.
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The prediction horizon magnitude is also analyzed. The possible coordinates available for prediction when the horizon is larger (n=10, m=5), depict a less dense possibility of coordinates when compared with shorter horizons of prediction. Short prediction horizon strategy is more time effective and performs path-tracking with better accuracy. For these reasons, a short horizon strategy (n=5, m=3) is proposed for implementing experimental results.
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Figure 4.
Trajectory tracking simulated result by using the orientation error, trajectory distance and the final desired point for the optimization.
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The sampling time for each LMPC step was set to 100ms. Simulation time performance of complete input search and gradient descent methods is computed. For short prediction horizon (n=5, m=3), the simulation processing time is less than 3ms for the complete input search strategy and less than 1ms for the gradient descent method when algorithms are running in a standard 2.7 GHz PC. Real on-robot algorithm time performance is also compared for different prediction horizons by using the embedded 700 Mhz PC and additional hardware system. Table 3 shows the LMPC processing time for different horizons of prediction when complete optimal values search or the gradient descent method are used. Surprisingly, when the horizon is increased the computing time is decreased. It is due to the fact that the control horizon is also incremented, and consequently less range of signal increments are possible because the signal increment is kept fixed within the control horizon. Thus, the maximum input value possibilities decrease with larger horizons. Hence for n=5 there are 1764 possibilities (42x42), and for n=10 there are 625 (25x25).
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Horizon of prediction (n)
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Complete search method
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Gradient descent method
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n=5
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45ms
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16ms
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n=8
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34ms
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10ms
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n=10
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25ms
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7ms
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Table 3.
LMPC processing times
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3. Tuning the control law parameters by using path-tracking experimental results
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In this section, path-tracking problem and the cost function parameter weights are analyzed, within a constrained field of perception provided by the on-robot sensor system. The main objective is to obtain further control law analysis by experimenting different kind of trajectories. The importance of the cost function parameter weights is analyzed by developing the factorial design of experiments for a representative set of local trajectories. Statistical results are compared and control law performance is analyzed as a function of the path to be followed. Experimental LMPC results are conducted by considering a constrained horizon of perception provided by a monocular camera where artificial potential fields are used in order to obtain the desired coordinates within the field of view of the robot.
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3.1. The local field of perception
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In order to test the LMPC by using constrained local perception, the field of view obtained by a monocular camera has been used. Ground available scene coordinates appear as an image, in which the camera setup and pose knowledge are used, and projective perspective is assumed to make each pixel coordinate correspond to a 3D scene coordinate (Horn, 1998). Fig. 5 shows a local map provided by the camera, which corresponds to a field of view with a horizontal angle of 48º, a vertical angle of 37º, H set to 109cm and a tilt angle of 32º.
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Figure 5.
Available local map coordinates (in green), the necessary coordinates free of obstacles and the necessary wide-path (in red).
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It is pointed out that the available floor coordinates are reduced due to the WP (wide-path) of the robot (Schilling, 1990). It should also be noted that for each column position corresponding to scene coordinates Y\n\t\t\t\t\t\n\t\t\t\t\t\tj\n\t\t\t\t\t\n\t\t\t\t\t, there are R row coordinates X\n\t\t\t\t\t\n\t\t\t\t\t\ti\n\t\t\t\t\t. Once perception is introduced, the problem is formulated as finding the optimal cell that brings the WMR close to the desired coordinates (X\n\t\t\t\t\t\n\t\t\t\t\t\td\n\t\t\t\t\t\n\t\t\t\t\t, Y\n\t\t\t\t\t\n\t\t\t\t\t\td\n\t\t\t\t\t) by searching for the closest local desired coordinates (X\n\t\t\t\t\t\n\t\t\t\t\t\tld\n\t\t\t\t\t\n\t\t\t\t\t, Y\n\t\t\t\t\t\n\t\t\t\t\t\tld\n\t\t\t\t\t) within the available local coordinates (X\n\t\t\t\t\t\n\t\t\t\t\t\ti\n\t\t\t\t\t\n\t\t\t\t\t, Y\n\t\t\t\t\t\n\t\t\t\t\t\tj\n\t\t\t\t\t). In this sense, perception is considered to be a local receding horizon on which the trajectory is planned. The local desired cell is obtained by minimizing a cost function J that should act as a potential field corridor. Thus, the cost function is minimized by attracting the robot to the desired objective through the free available local cell coordinates. It is noted that from local perception analysis and attraction potential fields a local on field path can be obtained. The subsequent subsections infer control law parameter analysis by considering a set of path possibilities obtained within the perception field mentioned in this section.
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3.2. The path-tracking experimental approach by using LMPC methods
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The path tracking performance is improved by the adequate choice of a cost function that is derived from (3) and consists of a quadratic expression containing some of the following four parameters to be minimized:
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The squared Euclidean approaching point distance (APD) between the local desired coordinates, provided by the on-robot perception system, and the actual robot position. It corresponds with the parameter “P” of the LMPC cost function given by (3).
The squared trajectory deviation distance (TDD) between the actual robot coordinate and a straight line that goes from the robot coordinates, when the local frame perception was acquired, and the local desired coordinates belonging to the referred frame of perception. It corresponds with the parameter “Q” of the cost function shown by (3).
The third parameter consists of the squared orientation deviation (OD); it is expressed by the difference between the robot desired and real orientations. It corresponds with the parameter “R” of the LMPC cost function depicted by (3).
The last parameter refers to changes allowed to the input signal. It corresponds with the parameter “S” of the LMPC cost function given by (3).
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One consideration that should be taken into account is the different distance magnitudes. In general, the approaching distance could be more than one meter. However, the magnitude of the deviation distance is normally in the order of cm, which becomes effective only when the robot is approaching the final desired point. Hence, when reducing the deviation distance further to less than 1cm is attempted, an increase, in the weight value for the deviation distance in the cost function, is proposed.
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The subsequent subsections use statistical knowledge for inferring APD (P) and TDD (Q) or APD (P) and OD (R) factor performances as a function of the kind of paths to be tracked. Other cost function parameters are assumed to be equal to zero.
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3.3. Experimental tuning of APD and TDD factors
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This subsection presents the results achieved by using factorial design in order to study the LMPC cost function tuning when APD and TDD factors are used. Path-tracking performance is analyzed by the mean of the different factor weights. The experiments are developed by considering five different kinds of trajectories within the reduced field of view as shown in Fig. 5. Therefore, straight, wide left turning, less left turning, wide right turning and less right turning trajectories are tested. Experiments are conducted by using factorial design with two levels of quantitative factors (Box et al, 2005). Referred to the cost function, let us assume that high value (H) is equal to “1” and low value (L) is equal to “0.5”. For each combination of factors three different runs are experimented. The averaged value of the three runs allows statistical analysis for each factor combination. From these standard deviations, the importance of the factor effects can be determined by using a rough rule that considers the effects when the value differences are similar or greater than 2 or 3 times their standard deviations. In this context, the main effects and lateral effects, related to APD and TDD, are analyzed. Fig. 6 shows the four factor combinations (APD, TDD) obtained by both factors with two level values.
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Figure 6.
The different factor combinations and the influence directions, in which the performances should be analyzed.
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The combinations used for detecting lateral and main effect combinations are highlighted by blue arrows. Thus, the main effect of APD factor, ME\n\t\t\t\t\t\n\t\t\t\t\t\tAPD\n\t\t\t\t\t, can be computed by the following expression:
Path-tracking statistical performances to be analyzed in this research are represented by Y. The subscripts depict the different factor combinations. The main effect for TDD factor, ME\n\t\t\t\t\t\n\t\t\t\t\t\tTDD\n\t\t\t\t\t, is computed by:
The detailed measured statistics with parameters such as time (T), trajectory error (TE), and averaged speeds (AS) are presented in (Pacheco & Luo, 2011). The results were tested for straight trajectories, wide and less left turnings, and wide and less right turnings. The main and lateral effects are represented in Table 4.
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The performance is analyzed for the different trajectories:
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The factorial analysis for straight line trajectories, (σT = 0.16s, σTE = 0.13cm, σAS = 2.15cm/s), depicts a main time APD effect of -0.45s, and an important lateral effect of -0.6s and -0.32cm. Speed lateral effect of only 1.9cm/s is not considered as meaningful. Considering lateral effects that improve time and accuracy, high values (APD, TDD) are proposed for both factors.
The analysis for wide left turning trajectories, (σT = 0.26s, σTE = 0.09cm, σAS = 0.54cm/s) show negative APD main effect of 0.53s, and 0.15cm. However, the TDD factor tends to decrease the time and trajectory deviation. The 0.3cm/s speed TDD main factor is irrelevant. In this case, low value for APD factor and high value for the TDD factor is proposed.
The factor analysis for less left turning, (σT = 0.29s, σTE = 0.36cm, σAS = 0.84cm/s), depicts a considerable lateral effect of -0.46s and -0.31cm. Speed -0.2cm/s lateral effect is not important. In this sense high values are proposed for APD and TDD factors.
The analysis for wide right turning, (σT = 0.18s, σTE = 0.15cm, σAS = 1.04cm/s) does not provide relevant clues, but small time improvement seems to appear when TDD factor is set to a low value. Low values are proposed for APD and TDD factors.
Finally, the factorial analysis for less right turning trajectories, (σT = 0.12s, σTE = 0.18cm, σAS = 1.94cm/s), depicts APD and lateral effects that increase the trajectory time with 0.32s and 0.44s. Main or lateral effects related to the speed have not been detected. Low values are proposed for APD and TDD factors.
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Straight line trajectory
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Parameter Performance
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Main Effect TDD factor
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Main Effect APD factor
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Lateral Effect TDD & APD factors
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Time
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-0.05s
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-0.45s
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-0.6s
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Trajectory accuracy
\n\t\t\t\t\t\t\t
-0.18cm
\n\t\t\t\t\t\t\t
-0.14cm
\n\t\t\t\t\t\t\t
-0.32cm
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Averaged speed
\n\t\t\t\t\t\t\t
1.25cm/s
\n\t\t\t\t\t\t\t
0.6cm/s
\n\t\t\t\t\t\t\t
1.9cm/s
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Wide left turn trajectory
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Time
\n\t\t\t\t\t\t\t
-0.34s
\n\t\t\t\t\t\t\t
0.53s
\n\t\t\t\t\t\t\t
0.16s
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory accuracy
\n\t\t\t\t\t\t\t
-0.17cm
\n\t\t\t\t\t\t\t
0.15cm
\n\t\t\t\t\t\t\t
-0.01cm
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Averaged speed
\n\t\t\t\t\t\t\t
0.3cm/s
\n\t\t\t\t\t\t\t
0.4cm/s
\n\t\t\t\t\t\t\t
0.7cm/s
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Slight left turn trajectory
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Time
\n\t\t\t\t\t\t\t
-0.24s
\n\t\t\t\t\t\t\t
0.02s
\n\t\t\t\t\t\t\t
-0.46s
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory accuracy
\n\t\t\t\t\t\t\t
-0.14cm
\n\t\t\t\t\t\t\t
-0.17cm
\n\t\t\t\t\t\t\t
-0.31cm
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Averaged speed
\n\t\t\t\t\t\t\t
0.8cm/s
\n\t\t\t\t\t\t\t
-1cm/s
\n\t\t\t\t\t\t\t
-0.2cm/s
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Wide right turn trajectory
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Time
\n\t\t\t\t\t\t\t
0.27s
\n\t\t\t\t\t\t\t
-0.10s
\n\t\t\t\t\t\t\t
0.17s
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory accuracy
\n\t\t\t\t\t\t\t
-0.22cm
\n\t\t\t\t\t\t\t
0.1cm
\n\t\t\t\t\t\t\t
-0.12cm
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Averaged speed
\n\t\t\t\t\t\t\t
0.7cm/s
\n\t\t\t\t\t\t\t
0.2cm/s
\n\t\t\t\t\t\t\t
0.9cm/s
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Slight right turn trajectory
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Time
\n\t\t\t\t\t\t\t
0.12s
\n\t\t\t\t\t\t\t
0.32s
\n\t\t\t\t\t\t\t
0.44s
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory accuracy
\n\t\t\t\t\t\t\t
-0.18cm
\n\t\t\t\t\t\t\t
-0.06cm
\n\t\t\t\t\t\t\t
-0.25cm
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Averaged speed
\n\t\t\t\t\t\t\t
-1.3cm/s
\n\t\t\t\t\t\t\t
2.8cm/s
\n\t\t\t\t\t\t\t
1.5cm/s
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 4.
Main and lateral effects
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.4. Experimental performance by using fixed or flexible APD & TDD factors
\n\t\t\t\t
Once factorial analysis is carried out, this subsection compares path-tracking performance by using different control strategies. The experiments developed consist in analyzing the performance when a fixed factor cost function or a flexible factor cost function is used. The trajectories to be analyzed are formed by straight lines, less right or left turnings, and wide right or left turnings. The fixed factor cost function maintains the high values for APD and TDD factors, while the flexible factor cost function is tested as function of the path to be tracked.
\n\t\t\t\t
Different experiments are done; see (Pacheco & Luo, 2011). As instance one experiment consists in tracking a trajectory that is composed of four points ((0, 0), (-25, 40), (-25, 120), (0, 160)) given as (x, y) coordinates in cm. It consists of wide left turning, straight line and wide right turning trajectories. The results obtained by using fixed and flexible factor cost function are depicted in Table 5. Three runs are obtained for each control strategy and consequently path-tracking performance analysis can be done.
\n\t\t\t\t
Results show that flexible factor strategy improves an 8% the total time performance of the fixed factor strategy. The turning trajectories are done near 50% of the path performed. Remaining path consists of a straight line trajectory that is performed with same cost
\n\t\t\t\t
Figure 7.
a) Trajectory-tracking experimental results by using flexible or fixed cost function. (b) WMR orientation experimental results by using flexible or fixed cost function. (c) Left wheel speed results by using flexible or fixed cost function. (d) Right wheel speed results by using flexible or fixed cost function.
\n\t\t\t\t
function values for fixed and flexible control laws. It is during the turning actions, where the two control laws have differences, when time improvement is nearly 16%. Fig. 7 shows an example of some results achieved. Path-tracking coordinates, angular position, and speed for the fixed and flexible cost function strategies are shown.
\n\t\t\t\t
It can be seen that flexible cost function, when wide left turning is performed approximately during the first three seconds, produces less maximum speed values when compared with fixed one. However, a major number of local maximum and minimum are obtained. It results in less trajectory deviation when straight line trajectory is commanded. In general flexible cost function produces less trajectory error with less orientation changes and improves time performance.
\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory points: (0,0), (-25,40), (-25,120), (0,160) ((x,y) in cm)
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Time (s)
\n\t\t\t\t\t\t\t
Trajectory error (cm)
\n\t\t\t\t\t\t\t
Averaged Speed (cm/s)
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Experiment
\n\t\t\t\t\t\t\t
Fixed Law
\n\t\t\t\t\t\t\t
Flexible Law
\n\t\t\t\t\t\t\t
Fixed Law
\n\t\t\t\t\t\t\t
Flexible Law
\n\t\t\t\t\t\t\t
Fixed Law
\n\t\t\t\t\t\t\t
Flexible Law
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Run 1
\n\t\t\t\t\t\t\t
10,5
\n\t\t\t\t\t\t\t
10,3
\n\t\t\t\t\t\t\t
3,243
\n\t\t\t\t\t\t\t
3,653
\n\t\t\t\t\t\t\t
18,209
\n\t\t\t\t\t\t\t
16,140
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Run 2
\n\t\t\t\t\t\t\t
10,9
\n\t\t\t\t\t\t\t
9,8
\n\t\t\t\t\t\t\t
3,194
\n\t\t\t\t\t\t\t
2,838
\n\t\t\t\t\t\t\t
16,770
\n\t\t\t\t\t\t\t
16,632
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Mean
\n\t\t\t\t\t\t\t
10,70
\n\t\t\t\t\t\t\t
10,05
\n\t\t\t\t\t\t\t
3,219
\n\t\t\t\t\t\t\t
3,245
\n\t\t\t\t\t\t\t
17,489
\n\t\t\t\t\t\t\t
16,386
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Variance
\n\t\t\t\t\t\t\t
0,0800
\n\t\t\t\t\t\t\t
0,1250
\n\t\t\t\t\t\t\t
0,0012
\n\t\t\t\t\t\t\t
0,3322
\n\t\t\t\t\t\t\t
1,0354
\n\t\t\t\t\t\t\t
0,1210
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Standart deviation
\n\t\t\t\t\t\t\t
0,2828
\n\t\t\t\t\t\t\t
0,3536
\n\t\t\t\t\t\t\t
0,0346
\n\t\t\t\t\t\t\t
0,5764
\n\t\t\t\t\t\t\t
1,0175
\n\t\t\t\t\t\t\t
0,3479
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 5.
Results obtained by using fixed or flexible cost function
\n\t\t\t\t
Developed experiences with our WMR platform show that flexible LMPC cost function related with the path to be tracked can improve the control system performance.
\n\t\t\t
\n\t\t\t
\n\t\t\t\t
3.5. Experimental tuning using APD and OD factors
\n\t\t\t\t
In a similar way APD and OD factors can be used. This subsection compares path-tracking performance by using different control strategies. The experiments developed consist in analyzing the performance when a fixed factor cost function or a flexible factor cost function is used. The trajectories to be analyzed are formed by straight lines, less right or left turnings, and wide right or left turnings. The fixed factor cost function maintains the high values for APD and OD factors, while the flexible factor cost function is tested as function of the path to be tracked. The experiments developed show the measured performance statistics, time, trajectory accuracy, and averaged speeds, for straight trajectories, wide and less left turnings, and wide and less right turnings. The standard deviation obtained as well as the main and lateral effects are represented in Table 6. The time, trajectory error and averaged speed standard deviations are respectively denoted by σT, σTE, and σAS. Table 6 represents the experimental statistic results obtained for the set of proposed trajectories. The standard deviations computed for each kind of trajectory by testing the different factor weights under different runs are also depicted.
\n\t\t\t\t
The main and lateral effects were calculated by using (6), (7), (8), and the mean values obtained for the different factor combinations. Therefore, in Table 6 are highlighted the significant results achieved using experimental factorial analysis. The inferred results obtained can be tested using different trajectories.
\n\t\t\t\t\t\t\t\tWide left turning\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Parameters
\n\t\t\t\t\t\t\t
OD
\n\t\t\t\t\t\t\t
APD
\n\t\t\t\t\t\t\t
APD & OD
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Time (s) σT = 0.06s
\n\t\t\t\t\t\t\t
-0,10
\n\t\t\t\t\t\t\t
0,20
\n\t\t\t\t\t\t\t
0,10
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory error (cm) σTE = 0.18cm
\n\t\t\t\t\t\t\t
0,36
\n\t\t\t\t\t\t\t
0,38
\n\t\t\t\t\t\t\t
0,02
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Speed (cm/s) σAS = 0.59cm/s
\n\t\t\t\t\t\t\t
0,36
\n\t\t\t\t\t\t\t
-0,87
\n\t\t\t\t\t\t\t
-0,52
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Less left turning
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Parameters
\n\t\t\t\t\t\t\t
OD
\n\t\t\t\t\t\t\t
APD
\n\t\t\t\t\t\t\t
APD & OD
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Time (s) σT = 0.09s
\n\t\t\t\t\t\t\t
-0,12
\n\t\t\t\t\t\t\t
0,07
\n\t\t\t\t\t\t\t
-0,05
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory error (cm) σTE = 0.11cm
\n\t\t\t\t\t\t\t
0,58
\n\t\t\t\t\t\t\t
1,08
\n\t\t\t\t\t\t\t
0,50
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Speed (cm/s) σAS = 0.92cm/s
\n\t\t\t\t\t\t\t
0,60
\n\t\t\t\t\t\t\t
-0,13
\n\t\t\t\t\t\t\t
0,47
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\tWide right turning\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Parameters
\n\t\t\t\t\t\t\t
OD
\n\t\t\t\t\t\t\t
APD
\n\t\t\t\t\t\t\t
APD & OD
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Time (s) σT = 0.11s
\n\t\t\t\t\t\t\t
0,10
\n\t\t\t\t\t\t\t
0,35
\n\t\t\t\t\t\t\t
0,45
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory error (cm) σTE = 0.08cm
\n\t\t\t\t\t\t\t
0,44
\n\t\t\t\t\t\t\t
0,45
\n\t\t\t\t\t\t\t
0,01
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Speed (cm/s) σAS = 0.67cm/s
\n\t\t\t\t\t\t\t
-0,58
\n\t\t\t\t\t\t\t
-1,67
\n\t\t\t\t\t\t\t
-2,25
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t\t\tLess right turning\n\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Parameters
\n\t\t\t\t\t\t\t
OD
\n\t\t\t\t\t\t\t
APD
\n\t\t\t\t\t\t\t
APD & OD
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Time (s) σT = 0.26s
\n\t\t\t\t\t\t\t
-0,07
\n\t\t\t\t\t\t\t
0,07
\n\t\t\t\t\t\t\t
0,00
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory error (cm) σTE = 0.20cm
\n\t\t\t\t\t\t\t
1,38
\n\t\t\t\t\t\t\t
0,65
\n\t\t\t\t\t\t\t
-0,73
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Speed (cm/s) σAS = 0.13cm/s
\n\t\t\t\t\t\t\t
-0,33
\n\t\t\t\t\t\t\t
-0,14
\n\t\t\t\t\t\t\t
-0,48
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 6.
Main and lateral effects
\n\t\t\t\t
The experiments developed consist in analyzing the time performance when a fixed factor cost function or a flexible factor cost function is used. The trajectories to be analyzed are formed by straight lines, less right or left turnings, and wide right or left turnings. The fixed factor cost function maintains the high values for APD and OD factors, while the flexible factor cost function is tested as function of the trajectory to be tracked. The experiments presented consist in tracking a trajectory that is composed of three points ((0, 0), (-25, 40), (-25, 120)) given as (x, y) coordinates in cm. The results obtained by using fixed and flexible factor cost function are depicted in Table 7.
\n\t\t\t\t
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\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Trajectory (x,y) in cm: (0,0), (-25,40), (-25,120)
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Features
\n\t\t\t\t\t\t\t
Time (s)
\n\t\t\t\t\t\t\t
Error (cm)
\n\t\t\t\t\t\t\t
Aver. speed (cm/s)
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Experiment
\n\t\t\t\t\t\t\t
Fixed
\n\t\t\t\t\t\t\t
Flexible
\n\t\t\t\t\t\t\t
Fixed
\n\t\t\t\t\t\t\t
Flexible
\n\t\t\t\t\t\t\t
Fixed
\n\t\t\t\t\t\t\t
Flexible
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Run 1
\n\t\t\t\t\t\t\t
7,2
\n\t\t\t\t\t\t\t
7,0
\n\t\t\t\t\t\t\t
3,8
\n\t\t\t\t\t\t\t
3,0
\n\t\t\t\t\t\t\t
19,4
\n\t\t\t\t\t\t\t
17,5
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Run 2
\n\t\t\t\t\t\t\t
7,4
\n\t\t\t\t\t\t\t
6,6
\n\t\t\t\t\t\t\t
2,2
\n\t\t\t\t\t\t\t
3,5
\n\t\t\t\t\t\t\t
16,5
\n\t\t\t\t\t\t\t
20,1
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Mean
\n\t\t\t\t\t\t\t
7,3
\n\t\t\t\t\t\t\t
6,8
\n\t\t\t\t\t\t\t
3,0
\n\t\t\t\t\t\t\t
3,2
\n\t\t\t\t\t\t\t
18,0
\n\t\t\t\t\t\t\t
18,8
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Variance
\n\t\t\t\t\t\t\t
0,02
\n\t\t\t\t\t\t\t
0,1
\n\t\t\t\t\t\t\t
1,3
\n\t\t\t\t\t\t\t
0,1
\n\t\t\t\t\t\t\t
4,2
\n\t\t\t\t\t\t\t
3,4
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t\t
Stand. dev.
\n\t\t\t\t\t\t\t
0,14
\n\t\t\t\t\t\t\t
0,3
\n\t\t\t\t\t\t\t
1,1
\n\t\t\t\t\t\t\t
0,3
\n\t\t\t\t\t\t\t
2,0
\n\t\t\t\t\t\t\t
1,9
\n\t\t\t\t\t\t
\n\t\t\t\t\t
Table 7.
Experimental performances
\n\t\t\t\t
Two runs are obtained for each strategy and consequently time performance analysis can be done. The averaged standard deviation between the two cost function systems is of 0.22s, and the difference of means are 0.5s. Thus, flexible factor strategy improves a 6.85% the time performance of the fixed factor strategy. However, left turning is done only a 33% of the trajectory. Thus, time improvement during the left turning is of near 20%. Fig. 8 shows an example of some results achieved. Path-tracking coordinates, angular position, and speed for the fixed and flexible cost function strategies are shown. Trajectory error and averaged speed statistical results are not significant, due to the fact that the differences of means between fixed and flexible laws are less than two times the standard deviations.
\n\t\t\t\t
Figure 8.
a) Trajectory-tracking experimental results by using flexible or fixed cost function. (b) WMR orientation experimental results by using flexible or fixed cost function. (c) Left wheel speed results by using flexible or fixed cost function. (d) Right wheel speed results by using flexible or fixed cost function.
\n\t\t\t
\n\t\t
\n\t\t
\n\t\t\t
4. Conclusion
\n\t\t\t
This research can be used on dynamic environments in the neighborhood of the robot. On-line LMPC is a suitable solution for low level path-tracking. LMPC is more time expensive when compared with traditional PID controllers. However, instead of PID speed control approaches, LMPC is based on a horizon of available coordinates within short prediction horizons that act as a reactive horizon. Therefore, path planning and convergence to coordinates can be more easily implemented by using LMPC methods. In this way, contractive constraints are used for guaranteeing the convergence towards the desired coordinates. The use of different dynamic models avoids the need of kinematical constraints that are inherent to other MPC techniques applied to WMR. In this context the control law is based on the consideration of two factors that consist of going straight or turning. Therefore, orientation deviation or trajectory deviation distance can be used as turning factors. The methodology used for performing the experiments is shown. From on-robot depicted experiences, the use of flexible cost functions with relationships to the path to be tracked can be considered as an important result. Thus, control system performance can be improved by considering different factor weights as a function of path to be followed.
\n\t\t\t
The necessary horizon of perception is constrained to just few seconds of trajectory planning. The short horizons allow real time implementations and accuracy trajectory tracking. The experimental LMPC processing time was 45ms, (m=3, n=5), running in the WMR embedded PC of 700MHz. The algorithms simplicity is another relevant result obtained. The factorial design, with two levels of quantitative factors, is presented as an easy way to infer experimental statistical data that allow testing feature performances as functionof the different factor combinations. Further studies on LMPC should be done in order to analyze its relative performance with respect to other control laws or to test the cost function performance when other factors are used. The influence of the motor dead zones is also an interesting aspect that should make further efforts to deal with it.
\n\t\t
\n\t
Acknowledgments
\n\t\t\t
This work has been partially funded by the Commission of Science and Technology of Spain (CICYT) through the coordinated projects DPI2007-66796-C03-02 and DPI 2008-06699-C02-01.
\n\t\t
\n',keywords:null,chapterPDFUrl:"https://cdn.intechopen.com/pdfs/16068.pdf",chapterXML:"https://mts.intechopen.com/source/xml/16068.xml",downloadPdfUrl:"/chapter/pdf-download/16068",previewPdfUrl:"/chapter/pdf-preview/16068",totalDownloads:2648,totalViews:184,totalCrossrefCites:1,totalDimensionsCites:2,totalAltmetricsMentions:1,impactScore:1,impactScorePercentile:61,impactScoreQuartile:3,hasAltmetrics:1,dateSubmitted:"October 25th 2010",dateReviewed:"February 6th 2011",datePrePublished:null,datePublished:"July 5th 2011",dateFinished:null,readingETA:"0",abstract:null,reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/16068",risUrl:"/chapter/ris/16068",book:{id:"160",slug:"advanced-model-predictive-control"},signatures:"Lluís Pacheco, Xavier Cufí and Ningsu Luo",authors:[{id:"30281",title:"Dr.",name:"Lluís",middleName:null,surname:"Pacheco",fullName:"Lluís Pacheco",slug:"lluis-pacheco",email:"lluispa@eia.udg.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"32046",title:"Dr.",name:"Ningsu",middleName:null,surname:"Luo",fullName:"Ningsu Luo",slug:"ningsu-luo",email:"ningsu.luo@udg.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null},{id:"118672",title:"Dr.",name:"Xavier",middleName:null,surname:"Cufí",fullName:"Xavier Cufí",slug:"xavier-cufi",email:"xcuf@eia.udg.edu",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institution:null}],sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_2",title:"2. The control system identification and the MPC formulation",level:"1"},{id:"sec_2_2",title:"2.1. Experimental model and system identification",level:"2"},{id:"sec_3_2",title:"2.2. Dynamic MPC techniques for local trajectory tracking",level:"2"},{id:"sec_3_3",title:"2.2.1. The LMPC formulation",level:"3"},{id:"sec_4_3",title:"Table 3.",level:"3"},{id:"sec_7",title:"3. Tuning the control law parameters by using path-tracking experimental results",level:"1"},{id:"sec_7_2",title:"3.1. The local field of perception",level:"2"},{id:"sec_8_2",title:"3.2. The path-tracking experimental approach by using LMPC methods",level:"2"},{id:"sec_9_2",title:"3.3. Experimental tuning of APD and TDD factors",level:"2"},{id:"sec_10_2",title:"3.4. Experimental performance by using fixed or flexible APD & TDD factors",level:"2"},{id:"sec_11_2",title:"3.5. Experimental tuning using APD and OD factors",level:"2"},{id:"sec_13",title:"4. Conclusion",level:"1"},{id:"sec_14",title:"Acknowledgments",level:"1"}],chapterReferences:[{id:"B1",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBox\n\t\t\t\t\t\t\tG. E. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHunter\n\t\t\t\t\t\t\tJ. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHunter\n\t\t\t\t\t\t\tW. G.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005 Statistics for Experimenters, Ed. John Wiley & Sons, 0-47171-813-0 Jersey (USA).\n\t\t\t'},{id:"B2",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBoyd\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tVandenberghe\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2004 Convex Optimization, Cambridge University Press, 9780521833783 New York (USA).\n\t\t\t'},{id:"B3",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFox\n\t\t\t\t\t\t\tD.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tBurgard\n\t\t\t\t\t\t\tW.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tThrun\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1997 The dynamic window approach to collision avoidance. IEEE Robotics & Automation Magazine, 4\n\t\t\t\t\t1 (Mar 1997) 23-33, 1070-9932\n\t\t\t\t\n\t\t\t'},{id:"B4",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGupta\n\t\t\t\t\t\t\tG. S.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMessom\n\t\t\t\t\t\t\tC. H.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tDemidenko\n\t\t\t\t\t\t\tS.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005 Real-time identification and predictive control of fast mobile robots using global vision sensor. IEEE Trans. On Instr. and Measurement, 54\n\t\t\t\t\t1 (February 2005) 200-214, 1557-9662\n\t\t\t\t\n\t\t\t'},{id:"B5",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tHorn\n\t\t\t\t\t\t\tB. K. P.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1998 Robot Vision. MIT press, Ed. McGraw-Hill, 0-26208-159-8England)\n\t\t\t'},{id:"B6",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKlancar\n\t\t\t\t\t\t\tG.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSkrjanc\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007 Tracking-error model-based predictive control for mobile robots in real time, Robotics and Autonomous Systems, 55\n\t\t\t\t\t6 (June 2007 ), 460\n\t\t\t\t\t469 , 0921-8890\n\t\t\t\t\n\t\t\t'},{id:"B7",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tKühne\n\t\t\t\t\t\t\tF.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLages\n\t\t\t\t\t\t\tW. F.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tGomes\n\t\t\t\t\t\t\tda.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSilva Jr\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t M., 2005 Model predictive control of a mobile robot using input-output linearization, Proceedings of Mechatronics and Robotics, 0-7803-9044-X Niagara Falls Canada, July 2005\n\t\t\t'},{id:"B8",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLjung\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1991 Issues in System Identification. IEEE Control Systems Magazine, 11\n\t\t\t\t\t1 (January 1991) 25-29, 0272-1708\n\t\t\t\t\n\t\t\t'},{id:"B9",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tMaciejowski\n\t\t\t\t\t\t\tJ. M.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2002 Predictive Control with Constraints, Ed. Prentice Hall, 0-20139-823-0England)\n\t\t\t'},{id:"B10",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNesterov\n\t\t\t\t\t\t\tI. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNemirovskii\n\t\t\t\t\t\t\tA.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNesterov\n\t\t\t\t\t\t\tY.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1994 Interior_Point Polynomial Methods in Convex Programming. Siam Studies in Applied Mathematics, 13 Publications, 0-89871-319-6\n\t\t\t\t\n\t\t\t'},{id:"B11",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tNorton\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1986 An Introduction to Identification. Academic Press, 0-12521-730-7 and New York, 1986\n\t\t\t'},{id:"B12",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tÖgren\n\t\t\t\t\t\t\tP.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLeonard\n\t\t\t\t\t\t\tN. E.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2005 A convergent dynamic window approach to obstacle avoidance. IEEE Transaction on Robotics, 21\n\t\t\t\t\t2 , (April 2005) 188-195, 1552-3098\n\t\t\t\t\n\t\t\t'},{id:"B13",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPacheco\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLuo\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCufí\n\t\t\t\t\t\t\tX.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2008 Predictive Control with Local Visual Data, In: Robotics, Automation and Control, Percherková, P., Flídr, M., Duník, J., 289\n\t\t\t\t\t306 , Publisher I-TECH, 978-9-53761-918-4 Printed in Croatia.\n\t\t\t'},{id:"B14",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPacheco\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLuo\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tFerrer\n\t\t\t\t\t\t\tI.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tCufí\n\t\t\t\t\t\t\tX.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2009 Interdisciplinary Knowledge Integration Through an Applied Mobile Robotics Course, The International Journal of Engineering Education, 25\n\t\t\t\t\t4 (July, 2009), 830\n\t\t\t\t\t840 , ISSN: 0949-149X\n\t\t\t'},{id:"B15",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tPacheco\n\t\t\t\t\t\t\tL.\n\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tLuo\n\t\t\t\t\t\t\tN.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2011 Mobile robot local trajectory tracking with dynamic model predictive control techniques, International Journal of Innovative Computing, Information and Control, 7\n\t\t\t\t\t6 (June 2011), in press, 1349-4198\n\t\t\t\t\n\t\t\t'},{id:"B16",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tSchilling\n\t\t\t\t\t\t\tR. J.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t1990 Fundamental of Robotics. Prentice-Hall (Ed.), New Jersey (USA) 1990, 0-13334-376-6\n\t\t\t\t\n\t\t\t'},{id:"B17",body:'\n\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\tWan\n\t\t\t\t\t\t\tJ.\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t2007 Computational reliable approaches of contractive MPC for discrete-time systems, PhD Thesis, University of Girona.\n\t\t\t'}],footnotes:[],contributors:[{corresp:"yes",contributorFullName:"Lluís Pacheco",address:"",affiliation:'
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HMMC (AL6063-SIC-B4C-MG)",doi:"10.5772/intechopen.104160",slug:"selection-and-fabrication-of-hmmc-al6063-sic-b4c-mg",body:'
1. Introduction
Figure 1 displays the flowchart of the HMMC development. During stir casting, a non-homogeneous mixture pattern has been an apprehension. The inclination is due to inappropriate segregation of reinforcement because of incorrect process parameters (rotation of stirrer, angle of stirring application, condition of wetting, and density). The material properties likewise have been reported to modify the characteristics of the homogeneous mix. The main metal matrix melted to obtain a molten state by melting it above its liquid temperature. The preheated reinforcement material is combined gradually so that a semi-solid-state is achieved. Repeatedly, the entire mix is needed to get heated to produce a molten state, and in between, stirring is done to attain the entirely conceivable consistency. The capability of the stir casting method predominantly rests on stirring speed, stirring duration, and stirring temperature [3, 4].
Figure 1.
Flow-chart of HMMC development.
Here a crucible composed of ceramic or graphite is being utilized to melt the parent metal in a furnace. A mechanized stirrer with a graphite impeller with a rotation speed of around 150–800rpm is engaged to agitate the melt (see Figure 2) periodically. The reinforcement materials are preheated to eliminate the humidity substances, facilitating wettability during stirring. Sakthivelu [2] had recommended a maximum limit of 30% of reinforcement for stable composites.
Figure 2.
Stir casting technique for the MMCs fabrication [1].
1.1 Stirring speed
The uniform dissemination of the reinforcement materials in the parent metal is essential for the advance in the coveted properties such as stiffness, toughness, tensile strength, etc. The stirrer with inadequate rpm provides an ineffectual activating force on the central metal matrix, contributing to an inadequate association [5]. Cluster arrangement and agglomeration inclination were recorded at slow rpm of mixing. The stirrer operated at high rpm provides considerable benefits in the creation of the expected composite since, at high rpm, the shear force supports the reinforced material to get the transfer inside the metal matrix dispersed phase and better bonding action with the metal matrix deep inside it, thereby setting up a coherent mix [5]. It has also been reported that porosity inclination can be stepped up at enhanced stirrer speed since gas particles induce inside the matrix.
1.2 Stirring duration
Stirring time likewise influences the distribution of dispersion into the metal matrix. Clustering of the material is observed at the lower stirring time, and further non-uniform mixture with fewer inclusions of reinforcement materials [6].
1.3 Stirring temperature
With a rise in temperature of the matrix metal, the viscosity was established to reduce, generating an effect in the reinforcement materials distribution. In extension, the chemical reaction was further revealed to develop with a rise in the temperature of the molten material [7].
2. Preparation of HMMC materials
The development of HMMC through stir casting typically uses the following phases. Figure 3 illustrates the phases of melting of metal matrix composite to its melting point. The stirring of molten metal is managed to utilize an electric motor.
Figure 3.
Phases of the stir casting process.
Table 1 displays the stir casting process parameters retained during the fabrication of HMMC.
S. No.
Parameters
Values
1
Preheating chamber temperature
850°C
2
Furnace temperature
900°C
3
Core temperature
750-800°C
4
Voltage
440 V
5
Frequency
50 Hz
6
Stirrer speed
300–400 rpm
7
Die pre-heating temperature
200°C
Table 1.
Stir casting process parameters.
The reinforcement material is delivered with continuous stirring movement through a stirrer to associate the reinforcements in the matrix of the parent metal. The mixture is eventually poured into the mold and solidifies naturally. The pertinent equipment employed for HMMC development is summarized.
2.1 Furnace
Figure 4 presents the original furnace adopted for the development of the HMMC. It has a temperature gauge with a regulator switch to regulate the temperature. The maximum temperature obtainable is around 1400°C. A convenient mechanical stir system generates a vortex in the melt, facilitating an exquisite melt blending, composing the metal matrix and related reinforcements. In order to evade the chances of solid particles settlement at the base of the crucible, a bottom pouring furnace is likewise suggested.
Figure 4.
Electric furnace used for HMMC development.
2.2 Mechanical stirrer rotor
The mechanical stirrer plays an essential role in forming an acceptable vortex in the melt to bring about the best possible coherence. Distinctive impeller stirrers can be used, i.e., single, double, and multiblade impeller. The double blade impeller (Figure 5) is employed mainly to develop AMCs. The single and multiblade impeller is handled primarily in chemical industries.
Figure 5.
Actual photo of mechanical stirrer used.
Figure 6 displays impeller stirrers accepted for HMMC development. The blade was applied with a coating of zirconia onto a stainless-steel stirrer. The zirconia layer helps in averting probable reactions between the molted aluminum material and stainless steel of the stirrer. The impellers have been investigated for developing a sufficient vortex during the mixing process.
Figure 6.
Impeller stirrer and types.
2.3 Crucible
Crucible is a container in which the metal matrix is melted to its molten temperature and the desired refracting materials are being added. Nowadays, diverse materials consisting of Alumina, Tungsten, Graphite, etc. are being adopted as a crucible. For HMMC development, the reinforcement materials (SiC and B4C) were pre-heated in the Alumina crucible (Figure 7), whereas the parent metal (Al6063) is melted in a graphite crucible shown in Figure 8.
The Graphite crucible experiences the following advantages.
High melting temperature (2500°C).
It is easily accessible.
The cost is less in comparison to tungsten.
Graphite has good electrical conductivity.
Figure 7.
Alumina crucible.
Figure 8.
Graphite crucible.
2.4 Power supply
The induction resistance furnace with a temperature regulator is linked with a three-phase electricity supply. To control the current and voltage supply, an ammeter and voltmeter were associated with the circuit. Figure 9 illustrates the ammeter and voltmeter. The ammeter indicates the instantaneous current flowing in the circuit. The induction resistance furnace is engaged with moving iron type (M-Tech industries) with range 0-10A. The Voltmeter is likewise utilized for measuring the instantaneous voltage value across the circuit with a range 0–300 volt.
Figure 9.
Ammeter and voltmeter.
The current drawn by the electrical inductor furnace, depends on the furnace size, shape, and capabilities. The furnace shown withdraws around 55A to 75A. The efficiency spectrum of an electrical furnace is surprisingly modest; all modern electrical furnaces have an AFUE of 100%. That means that entire electric furnaces convert electricity into heat energy without any losses. Due to energy losses in ducts and the energy required to run a blower, the electric furnace is slightly expensive for operation [8]. The energy requirement is AC 380/7kw/50 Hz. The induction furnace also comprises a temperature regulator and digital display unit of temperature. Figure 10 shows the Digital display unit with a regulator switch.
Figure 10.
Digital display unit with regulator switch.
2.5 Die
A graphite material die was utilized to shape and solidify molten material obtained after the rigorous stirring of Al 6063, SiC, and B4C. The size of the die is 100 × 50 × 30 with a tapered shape. Figure 11 displays the die adopted for fabrication.
Figure 11.
Graphite die with HMMC brick.
3. Steps accepted for HMMC fabrication
STEP 1: The stir casting setup employed for fabricating 84% Al-10% SiC-5% B4C-1% Mg is shown in Figure 12. It consists of a furnace with a temperature range up to 14,000°C for heating the materials utilizing electrical resistance heating, which is the generally used technique of heat development. The mechanical stirrer fixed to the motor was supported inside the graphite crucible.
Figure 12.
Electric furnace.
STEP 2: A correct weight measurement of the constituents is determined utilizing an electronic balancer (see Figure 13a–c). The silicon carbide and boron carbide particles were preheated at 850-900°C to eliminate any traces of moisture and oxidize their surface, forming a silicon oxide (SiO2) layer (see Figure 14). This layer enhances the wettability of the composite [9].
Figure 13.
Wt. measurement of (a) Al 6063 material, (b) SiC (c) B4C.
Figure 14.
Preheating of SiC and B4C.
STEP 3: The Al 6063 billets were later melted in a new graphite crucible (see Figure 15). The temperature of the furnace was controlled between 850 and 950°C. A less slag was observed on the edges and was cut out by a graphite spoon. A uniform temperature of 700-750°C was secured, and flux was included in the melt to restrain oxidation [10].
Figure 15.
Aluminum billets melting in furnace.
STEP 4: The molten metal was later cooled naturally to a semi-solid state at around 550-600°C, and gradually preheated SiC, and B4C was included in the melt in fragments, and mechanical stirring was performed at 300–400 rpm (Figure 16).
Figure 16.
Motorized stirring of HMMC.
STEP 5: Less than 1% wt of magnesium (Mg) was also added to develop the wettability of the mixture [7]. The mix was continuously stirred for 5 minutes, and the consistent mixture was poured into the die. Figure 17 exhibits the graphite die along with the developed HMMC brick.
Figure 17.
Graphite die with HMMC brick.
STEP 6: The solidified HMMC brick (Figure 18) is taken out from the die and is processed and cut into suitable identical pieces (30 × 20× 5 mm) further for experimentation. The specimens were then packed in polythene pouches with unique identification marks. Few specimens were then forwarded to authorized labs for SEM analysis and mechanical testing.
Figure 18.
Solidified HMMC bricks.
4. Samples of HMMC
Figure 19(a) and (b) show the weight measurement of brick one and brick two. The brick was cut into a smaller size of 30 mm × 20mm × 5 mm for experimentation on Die Sinking EDM. The wire EDM (Annexure 4) was used for preciously cutting the bricks so that the internal grain structures were not disturbed. Figure 20 shows the line diagram of the HMMC sample, and Figure 21 shows the actual sample.
Figure 19.
(a). Wt. measurement of brick 1. (b). Wt. measurement of brick 2.
Figure 20.
Line diagram of the specimen.
Figure 21.
View of the sample.
5. HMMC properties and test analysis
5.1 Properties of the individual constituents
Aluminum 6063 is broadly employed as a general-purpose alloy in many engineering applications such as the extrusion process, owing to its fair strength [11]. Table 2 exhibits the constituents of Al6063.
Table 3 (a-c) presents the physical and thermal properties of B4C [12], Al6063 [4], and SiC [13], respectively.
(a) B4C
(b) SiC
(c) Al 6063
Properties
Value
Properties
Value
Properties
Value
Specific Heat (°C)
700
Coefficient of Thermal Expansion (°C)
4
Coefficient of Thermal Expansion (per o C)
0.000022
Melting Point (°C)
2783
Specific Heat (°C)
750
Thermal Conductivity (cal/cm2/ cm/ Celsius at 25°C)
0.285
Density (g/cm3)
2.55
Melting Point (°C)
2730
Electrical Conductivity (% copper standard at 20 °C)
33.5
Thermal Conductivity (W/mk)
17–42
Density (g/cm3)
3.21
Density (g/cm3)
2.64
Hardness (Kg/mm2)
2900–3580
Thermal Conductivity (W/mk)
120
Freezing Range (°C) approx.
625–525
Table 3.
(a, b) physical properties of B4C and SiC (c) thermal properties of Al6063.
Boron carbide (B4C) is one of the hardest materials available. Above 1250°C, it has been harder than cubic boron nitride and diamond. B4C is an alluring reinforcement substance owing to its unique balance between thermal and chemical properties. Moreover, it possesses a smaller density and greater hardness value of order 30 GPa. Thus, B4C-reinforced HMMCs fabricated through the moderate-cost stir casting structure have gained higher attractiveness among researchers [14, 15]. B4C has good mechanical strength with desired properties of neuron absorption [16].
Silicon carbide (SiC) is constituted of tetrahedra of silicon and carbon atoms with influential bonds in the crystal lattice. The SiC material has less thermal enlargement, immense strength, and thermal conductivity of greater order and has been recorded to be resistant against thermal shock [17, 18]. The SiC can tolerate severe temperatures and has got high hardness coupled with low density.
Magnesium (Mg) is acknowledged for promoting grain refinement, wettability, and reinforcing the solid solution [19].
5.2 Properties of the HMMC
The spark atomic emission spectrometry (SAES) was conducted with ASTM E1251–11 standards (test procedure for Al and Al alloys) to determine the elements present in the HMMC samples. Table 4(a) illustrates the composition and %wt of elements. Table 4(b) indicates the HMMC significant properties. The density of HMMC (2637 kg/m3) as obtained through the test report has been used to calculate the MRR and EWR [20, 21].
(a)
(b)
HMMC
% Wt
HMMC
% Wt
Properties
Value
Al
91.43
Mg
0.087
Si
4.151
Cr
0.037
Melting point
750–800
Cu
1.516
Ti
0.027
U.T.S
110Mps
Zn
1.498
Sn
0.022
Tensile Strength
118 Mpa
Fe
0.806
V
0.006
Break Load
9.44KN
Mn
0.149
Cd
0.0019
Yield Stress
82 Mps
Ni
0.13
Co
<0.001
Hardness
72HB
Pb
0.089
Density
2637 kg/m3
Table 4.
(a) Composition of HMMC (b) significant properties of HMMC.
5.3 SEM analysis of the HMMC
For establishing the homogeneity of the HMMC, the sample was tested by employing scanning electron microscopy (SEM). Figure 22 displays the uniform dispersion of SiC and B4C in the specimen. No segregation of SiC grains along with B4C particles was stationed along the grain edges. Dissemination of grains is acknowledged to be intra-granular, in which the maximum particles locate inside the grains. The uniform distribution is commensurate with the efficient and timely stirring action during the stir casting process [22]. The crater’s size is less with B4C particles this could be because of the creation of a boron oxide (B2O3) layer on the B4C ceramic, because of liquid-to-liquid reaction leading to an expansion in the wettability, which is observable at a specialized high temperature [23]. Many researchers proposed that reinforcement in the particulate form up to wt. 30% may be included in a molten metal matrix to perform a more substantial reinforcement distribution [24]. Reinforcement is added emphatically into the molten stage of aluminum. The stirring speed, time of stir, stirrer blade angle, pouring temperature, solidification rate, reinforcement size, and elements percentage influence the fabricated composite consistency.
Figure 22.
SEM image of the stir casted HMMC.
6. Environmental concerns
The stir casting process involves melting the metal at around 800-1000°C. The metal matrix used is Aluminum 6063 with Boron Carbide (B4C) and Silicon Carbide (SiC) as reinforced materials. The melting operation produces specific unwanted gases and residual waste, which must be discussed. Table 5 illustrates the relevant unwanted gases/residual waste with apprehensions on the environment and human beings [27].
Sr. No
Unwanted Gases/ Residual Waste
Environmental concerns and human health
1
Aluminum hydroxide
Exposure to Aluminum hydroxide may cause repulsion, vomiting, hyperacidity, pungency, Low blood phosphates (hypophosphatemia), distaste, causticity leading to bowel obstruction, Fecal impaction [25].
2
Aluminum oxides
Indicative toxicity has been reported, followed by chronic inhalation of the aluminum oxides. Long-term aluminum oxide inhalation may cause pneumoconiosis with cold and exertion and a restrictive pattern of rib cage function. In severe cases, death has been reported due to respiratory failure.
3
Aluminum sulfates
Eating or gulping aluminum sulfate produces serious disturbance to the digestive organs and stomach. An influenced individual may encounter retching, queasiness, and runs, adding water to aluminum sulfate can make a sulfuric acid structure. The sulfuric acid may cause soil damage by reducing its constituents.
4
Boron Oxides
Acute effects: The boron oxides contacts can aggravate the skin and eyes. Breathing in Boron Oxide can bother the nose and throat, causing hacking and wheezing. Introduction to Boron Oxide may cause heaving wooziness, cerebral pain, sickness, and so forth.
Chronic Effects: The accompanying long-haul wellbeing influences may happen after some time getting an introduction to Boron Oxide and can keep going for months to years [26]. Boron oxide may make permanent damage to kidney and livers.
5
Silicon Dioxide
Silicon Dioxide exists naturally on earth and our bodies. No evidence has been reported to advocate its implication on human health, but more research is required to ascertain its role on the body. Inhalation of silica dust may cause diseases related to breathing.
6
Fly Ash particles
It can get placed in the deepest part of the lungs, where it may cause an asthmatic attack, inflammation, and immunological reactions. They contribute to Particulate Matter 2.5 and 10.
7
Magnesium Oxide
Exposure to Magnesium Oxide can cause “metal fume fever” which is a symptom in which the patent gets a metallic taste in the throat with headache, sneezing symptoms, cold symptoms.
Table 5.
List of unwanted gases/residual waste/effects on the environment.
7. Summary
This chapter focuses on the comprehensive development stages of the HMMC (84%wt of Al 6063–10%wt of SiC-5%wt of B4C with 1%wt. of Mg) through the stir casting method. A comprehensive description of the essential ingredients (electric furnace, stirrer, the crucible, die) required for HMMC fabrication and the procedures has been covered. Reinforcement is added emphatically into the molten stage of aluminum. The stirring speed, time of stir, stirrer blade angle, pouring temperature, solidification rate, reinforcement size, and elements percentage influence the fabricated composite consistency. The developed HMMC was further analyzed for composition and specific mechanical and thermal tests. The HMMC density of 2700 kg/m3 was noted for MRR calculations. For confirming the homogeneity of the HMMC, the sample was analyzed using an SEM test. Dissemination of grains was noticed to be intra-granular, in which the maximum particles reside inside the grains. The uniform distribution is proportional due to the efficient and timely stirring action during the stir casting process. The crater’s size is observed to be less with B4C particles because of the creation of a boron oxide (B2O3) layer on the B4C ceramic because of liquid-to-liquid reaction leading to an expansion in the wettability, which is observable at a specialized high temperature. During the stir casting process, the melting action of material emits out certain gases and residuals apart from the required composite. The residuals have specific environmental concerns. The severe effects caused by aluminum hydroxide, aluminum oxide, aluminum sulfate, boron oxide, silicon dioxide, magnesium oxide, and fly ash on the environment have also been covered.
\n',keywords:"hybrid metal matrix composite, stir casting, aluminum composite, environment",chapterPDFUrl:"https://cdn.intechopen.com/pdfs/82183.pdf",chapterXML:"https://mts.intechopen.com/source/xml/82183.xml",downloadPdfUrl:"/chapter/pdf-download/82183",previewPdfUrl:"/chapter/pdf-preview/82183",totalDownloads:3,totalViews:0,totalCrossrefCites:0,dateSubmitted:"February 19th 2022",dateReviewed:"March 2nd 2022",datePrePublished:"June 10th 2022",datePublished:null,dateFinished:"June 10th 2022",readingETA:"0",abstract:"This unit deals with the selection and fabrication of HMMC (Al6063-10SiC-5B4C-Mg) constituents by extensive biography review and satisfactory fabrication design. Researchers have promoted an extensive collection of Al6063 composites employing organic and inorganic reinforcements. The fundamental purpose of the broken-up stages is to constrain the metal matrix in a relevant capacity to strengthen the properties of the base materials. In the case of Al6063, the reinforcement weighty subject matter in the composite varies from 5 wt.% to 30 wt.%. Diverse classes of reinforcements had sought to integrate and operate in the composite formulation as hybrid reinforcements. This chapter further discusses the comprehensive development stages of 84% wt of Al 6063, 10% wt of SiC, 5% wt of B4C with 1% wt of Mg hybrid metal matrix composite (HMMC) through the stir casting approach. During the stir casting process, the melting action of the material emanates numerous gases and residuals apart from the expected composite. The residuals have numerous environmental concerns, which require discussion since some of the vapors and substantial waste can lead to detrimental effects on the environment in terms of air and soil pollution.",reviewType:"peer-reviewed",bibtexUrl:"/chapter/bibtex/82183",risUrl:"/chapter/ris/82183",signatures:"Gurpreet Singh Matharou and Simran Kaur",book:{id:"11184",type:"book",title:"Optimum Composite Structures - Recent Advances, New Perspectives and Applications",subtitle:null,fullTitle:"Optimum Composite Structures - Recent Advances, New Perspectives and Applications",slug:null,publishedDate:null,bookSignature:"Dr. Samson Jerold Samuel Chelladurai and Prof. Ramakrishnan Thirumalaisamy",coverURL:"https://cdn.intechopen.com/books/images_new/11184.jpg",licenceType:"CC BY 3.0",editedByType:null,isbn:"978-1-80355-673-4",printIsbn:"978-1-80355-672-7",pdfIsbn:"978-1-80355-674-1",isAvailableForWebshopOrdering:!0,editors:[{id:"247421",title:"Dr.",name:"Samson Jerold Samuel",middleName:null,surname:"Chelladurai",slug:"samson-jerold-samuel-chelladurai",fullName:"Samson Jerold Samuel Chelladurai"}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"}},authors:null,sections:[{id:"sec_1",title:"1. Introduction",level:"1"},{id:"sec_1_2",title:"1.1 Stirring speed",level:"2"},{id:"sec_2_2",title:"1.2 Stirring duration",level:"2"},{id:"sec_3_2",title:"1.3 Stirring temperature",level:"2"},{id:"sec_5",title:"2. Preparation of HMMC materials",level:"1"},{id:"sec_5_2",title:"2.1 Furnace",level:"2"},{id:"sec_6_2",title:"2.2 Mechanical stirrer rotor",level:"2"},{id:"sec_7_2",title:"2.3 Crucible",level:"2"},{id:"sec_8_2",title:"2.4 Power supply",level:"2"},{id:"sec_9_2",title:"2.5 Die",level:"2"},{id:"sec_11",title:"3. Steps accepted for HMMC fabrication",level:"1"},{id:"sec_12",title:"4. Samples of HMMC",level:"1"},{id:"sec_13",title:"5. HMMC properties and test analysis",level:"1"},{id:"sec_13_2",title:"5.1 Properties of the individual constituents",level:"2"},{id:"sec_14_2",title:"5.2 Properties of the HMMC",level:"2"},{id:"sec_15_2",title:"5.3 SEM analysis of the HMMC",level:"2"},{id:"sec_17",title:"6. Environmental concerns",level:"1"},{id:"sec_18",title:"7. Summary",level:"1"}],chapterReferences:[{id:"B1",body:'Mishra D, Tulasi T. Experimental Investigation on Stir Casting Processing and Properties of Al 6082/SiC Metal Matrix Composites. In: GSVL N, Babu AV, Reddy SS, Dhanasekaran R, editors. Recent Trends in Mechanical Engineering. Vol. 14. Singapore: Springer; 2020. pp. 159-168. DOI: 10.1007/978-981-15-1124-0_14'},{id:"B2",body:'Sakthivelu S, Sethusundaram PP, Meignanamoorthy M, Ravichandran M. Synthesis of metal matrix composites through stir casting process – a review. Mechanics and Mechanical Engineering. 2018;22:357-370. DOI: 10.2478/mme-2018-0029'},{id:"B3",body:'Kareem A, Qudeiri JA, Abdudeen A, Ahammed T, Ziout A. A review on AA 6061 metal matrix composites produced by stir casting. Materials. 2021;14:175. DOI: 10.3390/ma14010175'},{id:"B4",body:'Matharou GS, Bhuyan BK. Experimental investigation of surface roughness in electric discharge machining of hybrid metal matrix composite. In: Govindan K, Kumar H, Yadav S, editors. Advances in Mechanical and Materials Technology. Vol. 20. Singapore: Springer; 2022. pp. 333-343. DOI: 10.1007/978-981-16-2794-1_30'},{id:"B5",body:'Mehta VR, Sutaria MP. Investigation on the effect of stirring process parameters on the dispersion of SiC particles inside melting crucible. Metals and Materials International. 2020;27:2989-3002. DOI: 10.1007/s12540-020-00612-0'},{id:"B6",body:'Sahu MK, Sahu RK. Fabrication of aluminum matrix composites by stir casting technique and stirring process parameters optimization. In: Vijayaram TR, editor. Advanced Casting Technologies. London, UK: InTech; 2018. DOI: 10.5772/intechopen.73485'},{id:"B7",body:'Sozhamannan GG, Prabu SB, Venkatagalapathy VSK. Effect of processing Paramters on metal matrix composites: Stir casting process. JSEMAT. 2012;02:11-15. DOI: 10.4236/jsemat.2012.21002'},{id:"B8",body:'Ravichandran M, Meignanamoorthy M, Chellasivam GP, Vairamuthu J, Kumar AS, Stalin B. Effect of stir casting parameters on properties of cast metal matrix composite. Materials Today: Proceedings. 2020;22:2606-2613. DOI: 10.1016/j.matpr.2020.03.391'},{id:"B9",body:'Bodukuri AK, Eswaraiah K, Pradeep V. Investigation on machining of hybrid metal matrix composite. MSF. 2019;969:846-851. DOI: 10.4028/www.scientific.net/MSF.969.846'},{id:"B10",body:'Bains PS, Sidhu SS, Payal HS. Fabrication and machining of metal matrix composites: A review. Materials and Manufacturing Processes. 2016;31:553-573. DOI: 10.1080/10426914.2015.1025976'},{id:"B11",body:'Venkatesulu M, Rama Kotaiah K. Production and mechanical properties of AL 6063/B4C composites. JMERD. 2019;42:46-49. DOI: 10.26480/jmerd.01.2019.46.49'},{id:"B12",body:'Gudipudi S, Nagamuthu S, Subbian KS, Chilakalapalli SPR. Enhanced mechanical properties of AA6061-B4C composites developed by a novel ultra-sonic assisted stir casting. Engineering Science and Technology, an International Journal. 2020;23:1233-1243. DOI: 10.1016/j.jestch.2020.01.010'},{id:"B13",body:'Das S, Acharya U, Rao SVVNS, Paul S, Roy BS. Assessment of the surface characteristics of aerospace grade AA6092/17.5 SiCp-T6 composite processed through EDM. CIRP Journal of Manufacturing Science and Technology. 2021;33:123-132. DOI: 10.1016/j.cirpj.2021.03.005'},{id:"B14",body:'Patidar D, Rana RS. Effect of B 4 C particle reinforcement on the various properties of aluminium matrix composites: A survey paper. Materials Today: Proceedings. 2017;4:2981-2988. DOI: 10.1016/j.matpr.2017.02.180'},{id:"B15",body:'Toptan F, Kilicarslan A, Karaaslan A, Cigdem M, Kerti I. Processing and microstructural characterisation of AA 1070 and AA 6063 matrix B4Cp reinforced composites. Materials & Design. 2010;31:S87-S91. DOI: 10.1016/j.matdes.2009.11.064'},{id:"B16",body:'Naidu VVB, Varaprasad KC, Prahlada Rao K. Machinability analysis on wire electrical discharge machining of stir casted AA2024/Al 2 O 3/BN hybrid composite for aerospace applications. Materials and Manufacturing Processes. 2021;36:730-743. DOI: 10.1080/10426914.2020.1854466'},{id:"B17",body:'Pul M. Effect of sintering on mechanical property of SiC/B 4 C reinforced aluminum. Materials Research Express. 2018;6:016541. DOI: 10.1088/2053-1591/aacee1'},{id:"B18",body:'Sivananthan, S., Ravi, K., Samson Jerold Samuel, C., 2020. Effect of SiC particles reinforcement on mechanical properties of aluminium 6061 alloy processed using stir casting route. Materials Today: Proceedings 21, 968–970. doi:10.1016/j.matpr.2019.09.068'},{id:"B19",body:'Suneesh E, Sivapragash M. Comprehensive studies on processing and characterization of hybrid magnesium composites. Materials and Manufacturing Processes. 2018;33:1324-1345. DOI: 10.1080/10426914.2018.1453155'},{id:"B20",body:'Matharou GS, Bhuyan BK. Parametric optimization of EDM processes for aluminum hybrid metal matrix composite using GRA-PCA approach. International Journal of Mechanical and Production Engineering Research and Development. 2020; 10: 367–378. DOI: 10.24247/ijmperdjun202034.'},{id:"B21",body:'Matharou GS, Bhuyan BK. Modelling and combined effect analysis of electric discharge Machining process using response surface methodology. Materials Today: Proceedings. 2021;46:6638-6643. DOI: 10.1016/j.matpr.2021.04.103'},{id:"B22",body:'Senthilkumar TS, Muralikannan R. Role of TiC and h-BN particles on morphological characterization and surface effects of Al 4032 hybrid composites using EDM process. Journal of Mechanical Science and Technology. 2019;33:4255-4264. DOI: 10.1007/s12206-019-0822-z'},{id:"B23",body:'Bystrenko O, Jiang J, Dong F, Li X, Qiu J, Liu J, et al. Kinetics of bonds at structural breakdown in boron carbide under intensive loads: A molecular dynamics study. Computational Materials Science. 2020;180:109711. DOI: 10.1016/j.commatsci.2020.109711'},{id:"B24",body:'Garg P, Jamwal A, Kumar D, Sadasivuni KK, Hussain CM, Gupta P. Advance research progresses in aluminium matrix composites: Manufacturing & applications. Journal of Materials Research and Technology. 2019;8:4924-4939. DOI: 10.1016/j.jmrt.2019.06.028'},{id:"B25",body:'Bahrami A, Soltani N, Pech-Canul MI, Gutiérrez CA. Development of metal-matrix composites from industrial/agricultural waste materials and their derivatives. Critical Reviews in Environmental Science and Technology. 2016;46:143-208. DOI: 10.1080/10643389.2015.1077067'},{id:"B26",body:'Wang QG, Crepeau PN, Davidson CJ, Griffiths JR. Oxide films, pores and the fatigue lives of cast aluminum alloys. Metallurgical and Materials Transactions B. 2006;37:887-895. DOI: 10.1007/BF02735010'},{id:"B27",body:'Matharou GS, Bhuyan BK. Hybrid Metal Matrix Composite Development by Stir Casting and Environmental Concerns. Vol. 17. Singapore: Advances in Engineering Materials Springer; 2021. pp. 377-386. DOI: 10.1007%2F978-981-33-6029-7_35'}],footnotes:[],contributors:[{corresp:null,contributorFullName:"Gurpreet Singh Matharou",address:null,affiliation:'
Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India
Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India
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He began his scientific training at the University of Queensland where he studied as an undergraduate and subsequently as a research student. He graduated with a B.S. degree (honors, first class) in 1975 and an M.S. degree in 1978, having published the first molecular genetic studies of bacterial degradation of the herbicide 2,4D. He then moved to the Australian National University in Canberra where he conducted his Ph.D. studies on photosensory and thermosensory signal transduction in the multicellular migratory form (slug) of the cellular slime mould Dictyostelium discoideum. The next move was to the Max Planck Institute for Biochemistry in Munich, Germany, where he worked for 5 years on photosensory, thermosensory, and chemosensory responses in the multicellular and unicellular stages of the Dictyostelium life cycle. In 1985, he took up a position at La Trobe University where he remained until appointed to the Chair of Microbiology in 2004. In the 1990s, a serendipitous discovery resulted in a change in his research direction and led him to initiate the study of mitochondrial biogenesis and disease in Dictyostelium. In 2007, he was awarded the prestigious Australasian Science Prize for the discovery in his laboratory the Dictyostelium model; the cytopathology of mitochondrial disease is caused not by a lack of ATP but by the chronic activity of AMP-activated protein kinase (AMPK), an energy-sensing alarm protein. 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At IntechOpen, we not only specialize in the publication of Book Chapters as part of our Edited Volumes, but also the publication and dissemination of longer manuscripts, known as Long Form Monographs. Monographs allow Authors to focus on presenting a single subject or a specific aspect of that subject and publish their research in detail.
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Even if you have an area of research that does not at first sight fit within a previously defined IntechOpen project, we can still offer support and help you in publishing your individual research. Publishing your IntechOpen book in the form of a Long Form Monograph is a viable alternative.
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MONOGRAPH - LONG FORM MANUSCRIPT
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130 - 500 pages
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Primary research and original scholarship presented in detail
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*The price does not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate applied in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT by providing us with their VAT registration number. This is made possible by the EU reverse charge method.
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IntechOpen has collaborated with Enago, through its sister brand, Ulatus, which is one of the world’s leading providers of book translation services. The services are designed to convey the essence of your work to readers from across the globe in a language they understand. Enago’s expert translators incorporate cultural nuances in translations to make the content relevant for local audiences while retaining the original meaning and style. Enago translators are equipped to handle all complex and multiple overlapping themes encompassed in a single book and their high degree of linguistic and subject expertise enables them to deliver a superior quality output.
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FUNDING
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We feel that financial barriers should never prevent researchers from publishing their work. Please consult our Open Access Funding page to explore funding opportunities and learn more about how you can finance your IntechOpen publication.
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BENEFITS
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Your published content is immediately available to read, share and download for free
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Primary research and original scholarship presented in detail
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Single or multiple author manuscript
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Conference Proceedings - collection of papers presented at a conference published in book format
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COST
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10,000 GBP Monograph - Long Form
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The final price includes project management, editorial and peer-review services, technical editing, language copyediting, cover design, book layout, book promotion and ISBN assignment.
\n\n
*The price does not include Value-Added Tax (VAT). Residents of European Union countries need to add VAT based on the specific rate applied in their country of residence. Institutions and companies registered as VAT taxable entities in their own EU member state will not pay VAT by providing us with their VAT registration number. This is made possible by the EU reverse charge method.
\n\n
Optional Services
\n\n
IntechOpen has collaborated with Enago, through its sister brand, Ulatus, which is one of the world’s leading providers of book translation services. The services are designed to convey the essence of your work to readers from across the globe in a language they understand. Enago’s expert translators incorporate cultural nuances in translations to make the content relevant for local audiences while retaining the original meaning and style. Enago translators are equipped to handle all complex and multiple overlapping themes encompassed in a single book and their high degree of linguistic and subject expertise enables them to deliver a superior quality output.
\n\n
IntechOpen Authors that wish to use this service will receive a 20% discount on all translation services. To find out more information or obtain a quote, please visit: https://www.enago.com/intech.
\n\n
FUNDING
\n\n
We feel that financial barriers should never prevent researchers from publishing their work. Please consult our Open Access Funding page to explore funding opportunities and learn more about how you can finance your IntechOpen publication.
\n\n
BENEFITS
\n\n
\n\t
Your published content is immediately available to read, share and download for free
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+3.3 million unique visitors per month
\n\t
+184,650 Web Of Science citations
\n\t
You retain copyright to your work
\n\t
Chapter and book statistics performance reports allowing you to examine the reach of your content
\n\t
Full PDF version of your book available to download
\n\t
Rapid publishing process with personal support
\n\t
Competitive pricing for publishing services and print products
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by"}}],booksByTopicTotal:14,seriesByTopicCollection:[],seriesByTopicTotal:0,mostCitedChapters:[{id:"60895",doi:"10.5772/intechopen.76558",title:"An Overview of Cancer Treatment Modalities",slug:"an-overview-of-cancer-treatment-modalities",totalDownloads:3027,totalCrossrefCites:28,totalDimensionsCites:55,abstract:"Cancer is a global issue majorly affecting developing countries. According to a survey, 63% of deaths due to cancer are reported from developing countries. There are different conventional treatment modalities that are available to treat and manage cancer. However, new cancer treatment options are being explored continuously as over 60% of all current experimental trials worldwide are focusing on tumor cure. The success of treatment depends upon the type of cancer, locality of tumor, and its stage of progression. Surgery, radiation-based surgical knives, chemotherapy, and radiotherapy are some of the traditional and most widely used treatment options. Some of the modern modalities include hormone-based therapy, anti-angiogenic modalities, stem cell therapies, and dendritic cell-based immunotherapy. This chapter discusses different traditional and novel treatment modalities to combat different types of cancer.",book:{id:"6313",slug:"neoplasm",title:"Neoplasm",fullTitle:"Neoplasm"},signatures:"Zaigham Abbas and Sakina Rehman",authors:[{id:"214546",title:"Dr.",name:"Zaigham",middleName:null,surname:"Abbas",slug:"zaigham-abbas",fullName:"Zaigham Abbas"}]},{id:"64178",doi:"10.5772/intechopen.81517",title:"Zebrafish (Danio rerio) as a Model Organism",slug:"zebrafish-em-danio-rerio-em-as-a-model-organism",totalDownloads:2762,totalCrossrefCites:4,totalDimensionsCites:24,abstract:"Animals as model organisms, the silent sentinels, stand watch over the environmental health of the world. These are non-human animal species which can be used to understand specific biological processes and to obtain informations which can provide an insight into working of other organisms. Among the model organisms, the zebrafish (Danio rerio) is one of the best leading models to study developmental biology, cancer, toxicology, drug discovery, and molecular genetics. In addition, the zebrafish is increasingly used as a genetic model organism for aquaculture species and in toxicogenomics and also to generate zebrafish disease models for application in human biomedicines. This tiny fish is a versatile model organism for many fields of research because of its easy maintenance, breeding, and transparent body during early development.",book:{id:"7054",slug:"current-trends-in-cancer-management",title:"Current Trends in Cancer Management",fullTitle:"Current Trends in Cancer Management"},signatures:"Farmanur Rahman Khan and Saleh Sulaiman Alhewairini",authors:[{id:"221847",title:"Dr.",name:"Saleh",middleName:null,surname:"Alhewairini",slug:"saleh-alhewairini",fullName:"Saleh Alhewairini"},{id:"258210",title:"Dr.",name:"Farmanur Rahman",middleName:null,surname:"Khan",slug:"farmanur-rahman-khan",fullName:"Farmanur Rahman Khan"}]},{id:"61662",doi:"10.5772/intechopen.78271",title:"The Human Epidermal Growth Factor Receptor 2 (HER2) as a Prognostic and Predictive Biomarker: Molecular Insights into HER2 Activation and Diagnostic Implications",slug:"the-human-epidermal-growth-factor-receptor-2-her2-as-a-prognostic-and-predictive-biomarker-molecular",totalDownloads:1699,totalCrossrefCites:6,totalDimensionsCites:9,abstract:"The human epidermal growth factor receptor 2 (HER2) is a transmembrane tyrosine kinase receptor protein. HER2 gene amplification and receptor overexpression, which occur in 15–20% of breast cancer patients, are important markers for poor prognosis. Moreover, HER2-positive status is considered a predictive marker of response to HER2 inhibitors including trastuzumab and lapatinib. Therefore, reliable HER2 determination is essential to determine the eligibility of breast cancer patients to targeted anti-HER2 therapies. In this chapter, we aim to illustrate important aspects of the HER2 receptor as well as the molecular consequences of its aberrant constitutive activation in breast cancer. In addition, we will present the methods that can be used for the evaluation of HER2 status at different levels (protein, RNA, and DNA level) in clinical practice.",book:{id:"6813",slug:"cancer-prognosis",title:"Cancer Prognosis",fullTitle:"Cancer Prognosis"},signatures:"Daniela Furrer, Claudie Paquet, Simon Jacob and Caroline Diorio",authors:null},{id:"67964",doi:"10.5772/intechopen.87963",title:"Protein Tyrosine Phosphatases in Tumor Progression and Metastasis: Promoter or Protection?",slug:"protein-tyrosine-phosphatases-in-tumor-progression-and-metastasis-promoter-or-protection-",totalDownloads:919,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"Reversible phosphorylation of proteins, executed by kinases and phosphatases, is the major posttranslational protein modification in eukaryotic cells, causing them to become activated or deactivated. This intracellular event represents a critical regulatory mechanism of several signaling pathways and can be related to a broad number of diseases, including cancer. Few decades ago, protein tyrosine phosphatases (PTPs) were considered as tumor suppressors. However, nowadays, accumulating evidence demonstrates that a misregulation of PTP activities plays a crucial and decisive role in cancer progression and metastasis. In this chapter, we will focus on the molecular aspects that support the crucial role of PTPs in cancer and in turn make them promising for prediction, monitoring, and rational appropriate therapy selection of individual patients.",book:{id:"8002",slug:"tumor-progression-and-metastasis",title:"Tumor Progression and Metastasis",fullTitle:"Tumor Progression and Metastasis"},signatures:"Carmen V. Ferreira-Halder, Stefano Piatto Clerici, Alessandra V. Sousa Faria, Patrícia Fernandes de Souza Oliveira, Helon Guimarães Cordeiro and Erica Akagi",authors:[{id:"61709",title:"Prof.",name:"Carmen",middleName:null,surname:"Ferreira",slug:"carmen-ferreira",fullName:"Carmen Ferreira"},{id:"307647",title:"MSc.",name:"Stefano",middleName:null,surname:"Piatto Clerici",slug:"stefano-piatto-clerici",fullName:"Stefano Piatto Clerici"},{id:"307648",title:"Ph.D. Student",name:"Alessandra",middleName:"V. S.",surname:"Faria",slug:"alessandra-faria",fullName:"Alessandra Faria"},{id:"307649",title:"MSc.",name:"Patrícia",middleName:null,surname:"Oliveira",slug:"patricia-oliveira",fullName:"Patrícia Oliveira"},{id:"307650",title:"MSc.",name:"Helon",middleName:null,surname:"Cordeiro",slug:"helon-cordeiro",fullName:"Helon Cordeiro"},{id:"307651",title:"Dr.",name:"Erica",middleName:null,surname:"Akagi",slug:"erica-akagi",fullName:"Erica Akagi"}]},{id:"55760",doi:"10.5772/intechopen.69397",title:"Exosomes and Their Role in Viral Infections",slug:"exosomes-and-their-role-in-viral-infections",totalDownloads:2378,totalCrossrefCites:2,totalDimensionsCites:5,abstract:"Exosomes are excretory nano-vesicles that are formed by the cell’s endocytic system and shed from the surface of almost all types of cells. These tiny extracellular vesicles, once thought to be “garbage bags for cells,” carry a wide variety of molecules of cellular origin, including proteins, lipids, and RNAs, that are selectively incorporated during the formation of exosomes. Exosomes are now known to play a central role in several important biological processes such as cellular communication, intercellular transfer of bioactive molecules, and immune modulation. Recent advances in the field have shown that a number of animal viruses can exploit the exosomal pathway by incorporating specific cellular or viral factors within exosomes, in order to modulate the cellular microenvironment and influence downstream processes such as host immunity and virus spread. In this chapter, we provide an overview of our current understanding of exosome biogenesis and how this normal physiological process is hijacked by some pathogenic viruses. Viral components that appear to be selectively incorporated into exosomes and the potential role of these exosomes in viral pathogenesis are discussed. Identifying viral signatures in exosomes and their mode of action is fundamental for any future diagnostic and therapeutic strategies for viral infections.",book:{id:"5793",slug:"novel-implications-of-exosomes-in-diagnosis-and-treatment-of-cancer-and-infectious-diseases",title:"Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases",fullTitle:"Novel Implications of Exosomes in Diagnosis and Treatment of Cancer and Infectious Diseases"},signatures:"Gulfaraz Khan, Waqar Ahmed and Pretty S. Philip",authors:[{id:"199889",title:"Prof.",name:"Gulfaraz",middleName:null,surname:"Khan",slug:"gulfaraz-khan",fullName:"Gulfaraz Khan"},{id:"201764",title:"Mr.",name:"Waqar",middleName:null,surname:"Ahmed",slug:"waqar-ahmed",fullName:"Waqar Ahmed"},{id:"201766",title:"Ms.",name:"Pretty",middleName:null,surname:"Philip",slug:"pretty-philip",fullName:"Pretty Philip"}]}],mostDownloadedChaptersLast30Days:[{id:"60895",title:"An Overview of Cancer Treatment Modalities",slug:"an-overview-of-cancer-treatment-modalities",totalDownloads:3027,totalCrossrefCites:28,totalDimensionsCites:55,abstract:"Cancer is a global issue majorly affecting developing countries. According to a survey, 63% of deaths due to cancer are reported from developing countries. There are different conventional treatment modalities that are available to treat and manage cancer. However, new cancer treatment options are being explored continuously as over 60% of all current experimental trials worldwide are focusing on tumor cure. The success of treatment depends upon the type of cancer, locality of tumor, and its stage of progression. Surgery, radiation-based surgical knives, chemotherapy, and radiotherapy are some of the traditional and most widely used treatment options. Some of the modern modalities include hormone-based therapy, anti-angiogenic modalities, stem cell therapies, and dendritic cell-based immunotherapy. This chapter discusses different traditional and novel treatment modalities to combat different types of cancer.",book:{id:"6313",slug:"neoplasm",title:"Neoplasm",fullTitle:"Neoplasm"},signatures:"Zaigham Abbas and Sakina Rehman",authors:[{id:"214546",title:"Dr.",name:"Zaigham",middleName:null,surname:"Abbas",slug:"zaigham-abbas",fullName:"Zaigham Abbas"}]},{id:"64178",title:"Zebrafish (Danio rerio) as a Model Organism",slug:"zebrafish-em-danio-rerio-em-as-a-model-organism",totalDownloads:2762,totalCrossrefCites:4,totalDimensionsCites:24,abstract:"Animals as model organisms, the silent sentinels, stand watch over the environmental health of the world. These are non-human animal species which can be used to understand specific biological processes and to obtain informations which can provide an insight into working of other organisms. Among the model organisms, the zebrafish (Danio rerio) is one of the best leading models to study developmental biology, cancer, toxicology, drug discovery, and molecular genetics. In addition, the zebrafish is increasingly used as a genetic model organism for aquaculture species and in toxicogenomics and also to generate zebrafish disease models for application in human biomedicines. This tiny fish is a versatile model organism for many fields of research because of its easy maintenance, breeding, and transparent body during early development.",book:{id:"7054",slug:"current-trends-in-cancer-management",title:"Current Trends in Cancer Management",fullTitle:"Current Trends in Cancer Management"},signatures:"Farmanur Rahman Khan and Saleh Sulaiman Alhewairini",authors:[{id:"221847",title:"Dr.",name:"Saleh",middleName:null,surname:"Alhewairini",slug:"saleh-alhewairini",fullName:"Saleh Alhewairini"},{id:"258210",title:"Dr.",name:"Farmanur Rahman",middleName:null,surname:"Khan",slug:"farmanur-rahman-khan",fullName:"Farmanur Rahman Khan"}]},{id:"70898",title:"MicroRNA: A Signature for Cancer Diagnostics",slug:"microrna-a-signature-for-cancer-diagnostics",totalDownloads:956,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Various tools and techniques are being used for the diagnosis of cancer, but not a sole technique provides powerful result at the very early stages of cancer. This provides the need for type of tools which could detect cancer at early stages so that survival rate could be augmented. There are various diagnostic ways to identify cancer, but in each case, there are always circumstances to compromise on the sensitivity. In this framework, a new and more advanced approach of diagnosis for cancer is microRNA (miRNA). miRNAs are conserved regions among humans and animals, and their synthesis takes place in the nucleus and cytoplasm. There are several types of microRNAs that could be upregulated and downregulated in various cancers. A cancer cell could be identified by measurement of the expression pattern of miRNA. By examining the expression level for different types of cancers, miRNA can be used as biomarker for early detection of cancer in human beings.",book:{id:"9172",slug:"current-cancer-treatment",title:"Current Cancer Treatment",fullTitle:"Current Cancer Treatment"},signatures:"Ayesha Siddiqua, Sumaira Kousar, Amer Jamil, Riaz Tabassum, Tariq Mehmood and Nusrat Shafiq",authors:null},{id:"63685",title:"A Molecular Link between the Circadian Clock, DNA Damage Responses, and Oncogene Activation",slug:"a-molecular-link-between-the-circadian-clock-dna-damage-responses-and-oncogene-activation",totalDownloads:1391,totalCrossrefCites:0,totalDimensionsCites:1,abstract:"Circadian clocks enhance the efficiency and survival of living things by organizing their behavior and body functions. There has been a long history of research seeking a link between circadian clock and tumorigenesis. Studies of animal models and human tumor samples have revealed that the dysregulation of circadian clocks is an important endogenous factor causing mammalian cancer development. The core circadian clock regulators have been implicated in the control of both the cell cycle and DNA damage responses (DDR). Conversely, several intracellular signaling cascades that play important roles in regulation of the cell cycle and the DDR also contribute to circadian clock regulation. This review describes selected regulatory aspects of circadian clocks, providing evidence of a molecular link of the circadian clocks with cellular DDR.",book:{id:"7281",slug:"oncogenes-and-carcinogenesis",title:"Oncogenes and Carcinogenesis",fullTitle:"Oncogenes and Carcinogenesis"},signatures:"Yoshimi Okamoto-Uchida, Junko Izawa and Jun Hirayama",authors:[{id:"246364",title:"Prof.",name:"Jun",middleName:null,surname:"Hirayama",slug:"jun-hirayama",fullName:"Jun Hirayama"}]},{id:"67447",title:"Molecular Pathogenesis of Oral Squamous Cell Carcinoma",slug:"molecular-pathogenesis-of-oral-squamous-cell-carcinoma",totalDownloads:3777,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Oral carcinogenesis is a molecular and histological multistage process featuring genetic and phenotypic molecular markers which involves enhanced function of several protooncogenes, oncogenes and/or the deactivation of tumor suppressor genes, resulting in the over activity of growth factors and its cell surface receptors, which could enhance messenger signaling intracellularly, and/or leads to the increased production of transcription factors. Alone oncogenes are not responsible for carcinogenesis, genes having tumor suppressor activity, leads to a phenotypic change in cell which is responsible for increased cell proliferation, loss of cellular cohesion, and the ability to infiltrate local tissue and spread to distant sites. Understanding the molecular interplay of both onco and tumor genes will allow more accurate diagnosis and assessment of prognosis, which might lead the way for novel approaches to treatment.",book:{id:"8211",slug:"squamous-cell-carcinoma-hallmark-and-treatment-modalities",title:"Squamous Cell Carcinoma",fullTitle:"Squamous Cell Carcinoma - Hallmark and Treatment Modalities"},signatures:"Anshi Jain",authors:[{id:"280692",title:"Dr.",name:"Anshi",middleName:null,surname:"Jain",slug:"anshi-jain",fullName:"Anshi Jain"}]}],onlineFirstChaptersFilter:{topicId:"428",limit:6,offset:0},onlineFirstChaptersCollection:[],onlineFirstChaptersTotal:0},preDownload:{success:null,errors:{}},subscriptionForm:{success:null,errors:{}},aboutIntechopen:{},privacyPolicy:{},peerReviewing:{},howOpenAccessPublishingWithIntechopenWorks:{},sponsorshipBooks:{sponsorshipBooks:[],offset:0,limit:8,total:null},allSeries:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],testimonialsList:[]},series:{item:{id:"24",title:"Sustainable Development",doi:"10.5772/intechopen.100361",issn:null,scope:"
\r\n\tTransforming our World: the 2030 Agenda for Sustainable Development endorsed by United Nations and 193 Member States, came into effect on Jan 1, 2016, to guide decision making and actions to the year 2030 and beyond. Central to this Agenda are 17 Goals, 169 associated targets and over 230 indicators that are reviewed annually. The vision envisaged in the implementation of the SDGs is centered on the five Ps: People, Planet, Prosperity, Peace and Partnership. This call for renewed focused efforts ensure we have a safe and healthy planet for current and future generations.
\r\n
\r\n\t
\r\n
\r\n\tThis Series focuses on covering research and applied research involving the five Ps through the following topics:
\r\n
\r\n\t
\r\n
\r\n\t1. Sustainable Economy and Fair Society that relates to SDG 1 on No Poverty, SDG 2 on Zero Hunger, SDG 8 on Decent Work and Economic Growth, SDG 10 on Reduced Inequalities, SDG 12 on Responsible Consumption and Production, and SDG 17 Partnership for the Goals
\r\n
\r\n\t
\r\n
\r\n\t2. Health and Wellbeing focusing on SDG 3 on Good Health and Wellbeing and SDG 6 on Clean Water and Sanitation
\r\n
\r\n\t
\r\n
\r\n\t3. Inclusivity and Social Equality involving SDG 4 on Quality Education, SDG 5 on Gender Equality, and SDG 16 on Peace, Justice and Strong Institutions
\r\n
\r\n\t
\r\n
\r\n\t4. Climate Change and Environmental Sustainability comprising SDG 13 on Climate Action, SDG 14 on Life Below Water, and SDG 15 on Life on Land
\r\n
\r\n\t
\r\n
\r\n\t5. Urban Planning and Environmental Management embracing SDG 7 on Affordable Clean Energy, SDG 9 on Industry, Innovation and Infrastructure, and SDG 11 on Sustainable Cities and Communities.
\r\n
\r\n\t
\r\n
\r\n\tThe series also seeks to support the use of cross cutting SDGs, as many of the goals listed above, targets and indicators are all interconnected to impact our lives and the decisions we make on a daily basis, making them impossible to tie to a single topic.
",coverUrl:"https://cdn.intechopen.com/series/covers/24.jpg",latestPublicationDate:"June 28th, 2022",hasOnlineFirst:!0,numberOfPublishedBooks:0,editor:{id:"262440",title:"Prof.",name:"Usha",middleName:null,surname:"Iyer-Raniga",slug:"usha-iyer-raniga",fullName:"Usha Iyer-Raniga",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRYSXQA4/Profile_Picture_2022-02-28T13:55:36.jpeg",biography:"Usha Iyer-Raniga is a professor in the School of Property and Construction Management at RMIT University. Usha co-leads the One Planet Network’s Sustainable Buildings and Construction Programme (SBC), a United Nations 10 Year Framework of Programmes on Sustainable Consumption and Production (UN 10FYP SCP) aligned with Sustainable Development Goal 12. The work also directly impacts SDG 11 on Sustainable Cities and Communities. She completed her undergraduate degree as an architect before obtaining her Masters degree from Canada and her Doctorate in Australia. Usha has been a keynote speaker as well as an invited speaker at national and international conferences, seminars and workshops. Her teaching experience includes teaching in Asian countries. She has advised Austrade, APEC, national, state and local governments. She serves as a reviewer and a member of the scientific committee for national and international refereed journals and refereed conferences. She is on the editorial board for refereed journals and has worked on Special Issues. Usha has served and continues to serve on the Boards of several not-for-profit organisations and she has also served as panel judge for a number of awards including the Premiers Sustainability Award in Victoria and the International Green Gown Awards. Usha has published over 100 publications, including research and consulting reports. Her publications cover a wide range of scientific and technical research publications that include edited books, book chapters, refereed journals, refereed conference papers and reports for local, state and federal government clients. She has also produced podcasts for various organisations and participated in media interviews. She has received state, national and international funding worth over USD $25 million. Usha has been awarded the Quarterly Franklin Membership by London Journals Press (UK). Her biography has been included in the Marquis Who's Who in the World® 2018, 2016 (33rd Edition), along with approximately 55,000 of the most accomplished men and women from around the world, including luminaries as U.N. Secretary-General Ban Ki-moon. In 2017, Usha was awarded the Marquis Who’s Who Lifetime Achiever Award.",institutionString:null,institution:{name:"RMIT University",institutionURL:null,country:{name:"Australia"}}},editorTwo:null,editorThree:null},subseries:{paginationCount:5,paginationItems:[{id:"91",title:"Sustainable Economy and Fair Society",coverUrl:"https://cdn.intechopen.com/series_topics/covers/91.jpg",isOpenForSubmission:!0,editor:{id:"181603",title:"Dr.",name:"Antonella",middleName:null,surname:"Petrillo",slug:"antonella-petrillo",fullName:"Antonella Petrillo",profilePictureURL:"https://mts.intechopen.com/storage/users/181603/images/system/181603.jpg",biography:"Antonella Petrillo is a Professor at the Department of Engineering of the University of Naples “Parthenope”, Italy. She received her Ph.D. in Mechanical Engineering from the University of Cassino. Her research interests include multi-criteria decision analysis, industrial plant, logistics, manufacturing and safety. She serves as an Associate Editor for the International Journal of the Analytic Hierarchy Process. She is a member of AHP Academy and a member of several editorial boards. She has over 160 Scientific Publications in International Journals and Conferences and she is the author of 5 books on Innovation and Decision Making in Industrial Applications and Engineering.",institutionString:null,institution:{name:"Parthenope University of Naples",institutionURL:null,country:{name:"Italy"}}},editorTwo:null,editorThree:null},{id:"92",title:"Health and Wellbeing",coverUrl:"https://cdn.intechopen.com/series_topics/covers/92.jpg",isOpenForSubmission:!0,editor:{id:"348225",title:"Prof.",name:"Ann",middleName:null,surname:"Hemingway",slug:"ann-hemingway",fullName:"Ann Hemingway",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035LZFoQAO/Profile_Picture_2022-04-11T14:55:40.jpg",biography:"Professor Hemingway is a public health researcher, Bournemouth University, undertaking international and UK research focused on reducing inequalities in health outcomes for marginalised and excluded populations and more recently focused on equine assisted interventions.",institutionString:null,institution:{name:"Bournemouth University",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null},{id:"93",title:"Inclusivity and Social Equity",coverUrl:"https://cdn.intechopen.com/series_topics/covers/93.jpg",isOpenForSubmission:!0,editor:{id:"210060",title:"Prof. Dr.",name:"Ebba",middleName:null,surname:"Ossiannilsson",slug:"ebba-ossiannilsson",fullName:"Ebba Ossiannilsson",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6LkBQAU/Profile_Picture_2022-02-28T13:31:48.png",biography:"Professor Dr. Ebba Ossiannilsson is an independent researcher, expert, consultant, quality auditor and influencer in the fields of open, flexible online and distance learning (OFDL) and the 'new normal'. Her focus is on quality, innovation, leadership, and personalised learning. She works primarily at the strategic and policy levels, both nationally and internationally, and with key international organisations. She is committed to promoting and improving OFDL in the context of SDG4 and the future of education. Ossiannilsson has more than 20 years of experience in her current field, but more than 40 years in the education sector. She works as a reviewer and expert for the European Commission and collaborates with the Joint Research Centre for Quality in Open Education. Ossiannilsson also collaborates with ITCILO and ICoBC (International Council on Badges and Credentials). She is a member of the ICDE Board of Directors and has previously served on the boards of EDEN and EUCEN. Ossiannilsson is a quality expert and reviewer for ICDE, EDEN and the EADTU. She chairs the ICDE OER Advocacy Committee and is a member of the ICDE Quality Network. She is regularly invited as a keynote speaker at conferences. She is a guest editor for several special issues and a member of the editorial board of several scientific journals. She has published more than 200 articles and is currently working on book projects in the field of OFDL. Ossiannilsson is a visiting professor at several international universities and was recently appointed Professor and Research Fellow at Victoria University of Wellington, NZ. Ossiannilsson has been awarded the following fellowships: EDEN Fellows, EDEN Council of Fellows, and Open Education Europe. She is a ICDE OER Ambassador, Open Education Europe Ambassador, GIZ Ambassador for Quality in Digital Learning, and part of the Globe-Community of Digital Learning and Champion of SPARC Europe. On a national level, she is a quality developer at the Swedish Institute for Standards (SIS) and for ISO. She is a member of the Digital Skills and Jobs Coalition Sweden and Vice President of the Swedish Association for Distance Education. She is currently working on a government initiative on quality in distance education at the National Council for Higher Education. She holds a Ph.D. from the University of Oulu, Finland.",institutionString:"Swedish Association for Distance Education, Sweden",institution:null},editorTwo:null,editorThree:null},{id:"94",title:"Climate Change and Environmental Sustainability",coverUrl:"https://cdn.intechopen.com/series_topics/covers/94.jpg",isOpenForSubmission:!0,editor:{id:"61855",title:"Dr.",name:"Yixin",middleName:null,surname:"Zhang",slug:"yixin-zhang",fullName:"Yixin Zhang",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYWJgQAO/Profile_Picture_2022-06-09T11:36:35.jpg",biography:"Professor Yixin Zhang is an aquatic ecologist with over 30 years of research and teaching experience in three continents (Asia, Europe, and North America) in Stream Ecology, Riparian Ecology, Urban Ecology, and Ecosystem Restoration and Aquatic Conservation, Human-Nature Interactions and Sustainability, Urbanization Impact on Aquatic Ecosystems. He got his Ph.D. in Animal Ecology at Umeå University in Sweden in 1998. He conducted postdoc research in stream ecology at the University of California at Santa Barbara in the USA. After that, he was a postdoc research fellow at the University of British Columbia in Canada to do research on large-scale stream experimental manipulation and watershed ecological survey in temperate rainforests of BC. He was a faculty member at the University of Hong Kong to run ecological research projects on aquatic insects, fishes, and newts in Tropical Asian streams. He also conducted research in streams, rivers, and caves in Texas, USA, to study the ecology of macroinvertebrates, big-claw river shrimp, fish, turtles, and bats. 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Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. His research interests include root canal morphology, functionally graded concept, dental biomaterials, epidemiology and dental education, biomimetic restoration, finite element analysis and endodontic regeneration. Dr. Madfa has numerous international publications, full articles, two patents, a book and a book chapter. Furthermore, he won 14 international scientific awards. Furthermore, he is involved in many academic activities ranging from editorial board member, reviewer for many international journals and postgraduate students' supervisor. Besides, I deliver many courses and training workshops at various scientific events. Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Univeristy of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:null},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:null},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"355660",title:"Dr.",name:"Anitha",middleName:null,surname:"Mani",slug:"anitha-mani",fullName:"Anitha Mani",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"355612",title:"Dr.",name:"Janani",middleName:null,surname:"Karthikeyan",slug:"janani-karthikeyan",fullName:"Janani Karthikeyan",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"334400",title:"Dr.",name:"Suvetha",middleName:null,surname:"Siva",slug:"suvetha-siva",fullName:"Suvetha Siva",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}}]}},subseries:{item:{id:"10",type:"subseries",title:"Animal Physiology",keywords:"Physiology, Comparative, Evolution, Biomolecules, Organ, Homeostasis, Anatomy, Pathology, Medical, Cell Division, Cell Signaling, Cell Growth, Cell Metabolism, Endocrine, Neuroscience, Cardiovascular, Development, Aging, Development",scope:"Physiology, the scientific study of functions and mechanisms of living systems, is an essential area of research in its own right, but also in relation to medicine and health sciences. The scope of this topic will range from molecular, biochemical, cellular, and physiological processes in all animal species. Work pertaining to the whole organism, organ systems, individual organs and tissues, cells, and biomolecules will be included. Medical, animal, cell, and comparative physiology and allied fields such as anatomy, histology, and pathology with physiology links will be covered in this topic. 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Dr. Rutland has also written popular science books for the public. https://orcid.org/0000-0002-2009-4898. www.nottingham.ac.uk/vet/people/catrin.rutland",institutionString:null,institution:{name:"University of Nottingham",institutionURL:null,country:{name:"United Kingdom"}}},editorTwo:null,editorThree:null,series:{id:"10",title:"Physiology",doi:"10.5772/intechopen.72796",issn:"2631-8261"},editorialBoard:[{id:"306970",title:"Mr.",name:"Amin",middleName:null,surname:"Tamadon",slug:"amin-tamadon",fullName:"Amin Tamadon",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002oHR5wQAG/Profile_Picture_1623910304139",institutionString:null,institution:{name:"Bushehr University of Medical Sciences",institutionURL:null,country:{name:"Iran"}}},{id:"251314",title:"Dr.",name:"Juan Carlos",middleName:null,surname:"Gardón",slug:"juan-carlos-gardon",fullName:"Juan Carlos Gardón",profilePictureURL:"https://mts.intechopen.com/storage/users/251314/images/system/251314.jpeg",institutionString:"Catholic University of Valencia San Vicente Mártir, Spain",institution:null},{id:"245306",title:"Dr.",name:"María Luz",middleName:null,surname:"Garcia Pardo",slug:"maria-luz-garcia-pardo",fullName:"María Luz Garcia Pardo",profilePictureURL:"https://mts.intechopen.com/storage/users/245306/images/system/245306.png",institutionString:null,institution:{name:"Miguel Hernandez University",institutionURL:null,country:{name:"Spain"}}},{id:"283315",title:"Prof.",name:"Samir",middleName:null,surname:"El-Gendy",slug:"samir-el-gendy",fullName:"Samir El-Gendy",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRduYQAS/Profile_Picture_1606215849748",institutionString:null,institution:{name:"Alexandria University",institutionURL:null,country:{name:"Egypt"}}}]},onlineFirstChapters:{},publishedBooks:{},testimonialsList:[{id:"27",text:"The opportunity to work with a prestigious publisher allows for the possibility to collaborate with more research groups interested in animal nutrition, leading to the development of new feeding strategies and food valuation while being more sustainable with the environment, allowing more readers to learn about the subject.",author:{id:"175967",name:"Manuel",surname:"Gonzalez Ronquillo",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/175967/images/system/175967.png",slug:"manuel-gonzalez-ronquillo",institution:{id:"6221",name:"Universidad Autónoma del Estado de México",country:{id:null,name:"Mexico"}}}},{id:"18",text:"It was great publishing with IntechOpen, the process was straightforward and I had support all along.",author:{id:"71579",name:"Berend",surname:"Olivier",institutionString:"Utrecht University",profilePictureURL:"https://mts.intechopen.com/storage/users/71579/images/system/71579.png",slug:"berend-olivier",institution:{id:"253",name:"Utrecht University",country:{id:null,name:"Netherlands"}}}},{id:"8",text:"I work with IntechOpen for a number of reasons: their professionalism, their mission in support of Open Access publishing, and the quality of their peer-reviewed publications, but also because they believe in equality.",author:{id:"202192",name:"Catrin",surname:"Rutland",institutionString:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202192/images/system/202192.png",slug:"catrin-rutland",institution:{id:"134",name:"University of Nottingham",country:{id:null,name:"United Kingdom"}}}}]},submityourwork:{pteSeriesList:[],lsSeriesList:[],hsSeriesList:[],sshSeriesList:[],subseriesList:[],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:null},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/16068",hash:"",query:{},params:{id:"16068"},fullPath:"/chapters/16068",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var t;(t=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(t)}()