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He has authored over seven training manuals for Environmental Health Science, has published in over eighty-seven scientific journals, and has attended several scientific conferences both nationally and internationally.",coeditorThreeBiosketch:"Dr. Adias is a Fellow of the Institute of Biomedical Science (FIBMS), London, UK. His current research interest is focused on Transfusion immunology, safety, alternatives, and hematology of infectious diseases. 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Hamedi Sangari",slug:"h.-hamedi-sangari"}]},{id:"13617",title:"Modeling Moisture Movement in Rice",slug:"modeling-moisture-movement-in-rice",signatures:"Bhagwati Prakash and Zhongli Pan",authors:[{id:"20336",title:"Prof.",name:"Bhagwati",middleName:null,surname:"Prakash",fullName:"Bhagwati Prakash",slug:"bhagwati-prakash"},{id:"20337",title:"Prof.",name:"Zhongli",middleName:null,surname:"Pan",fullName:"Zhongli Pan",slug:"zhongli-pan"}]},{id:"13618",title:"Mass Transfer Mechanisms during Dehydration of Vegetable Food: Traditional and Innovative Approaches",slug:"mass-transfer-mechanisms-during-dehydration-of-vegetable-food-traditional-and-innovative-approaches",signatures:"Derossi A., Severini C. and Cassi D.",authors:[{id:"18604",title:"Dr.",name:"Antonio",middleName:null,surname:"Derossi",fullName:"Antonio Derossi",slug:"antonio-derossi"},{id:"20691",title:"Prof.",name:"Carla",middleName:null,surname:"Severini",fullName:"Carla Severini",slug:"carla-severini"},{id:"20694",title:"Prof.",name:"Davide",middleName:null,surname:"Cassi",fullName:"Davide Cassi",slug:"davide-cassi"}]},{id:"13619",title:"Mass Transfer in Cheese",slug:"mass-transfer-in-cheese",signatures:"Jorge F. Velez-Ruiz",authors:[{id:"19214",title:"Dr.",name:"Jorge",middleName:"Fernando",surname:"Velez-Ruiz",fullName:"Jorge Velez-Ruiz",slug:"jorge-velez-ruiz"}]},{id:"13620",title:"Comprehensive Survey of Multi-Elements in Coastal Sea and Stream Sediments in the Island Arc Region of Japan: Mass Transfer from Terrestrial to Marine Environments",slug:"comprehensive-survey-of-multi-elements-in-coastal-sea-and-stream-sediments-in-the-island-arc-region-",signatures:"Atsuyuki Ohta and Noboru Imai",authors:[{id:"17286",title:"Dr.",name:"Atsuyuki",middleName:null,surname:"Ohta",fullName:"Atsuyuki Ohta",slug:"atsuyuki-ohta"},{id:"24104",title:"Dr.",name:"Noboru",middleName:null,surname:"Imai",fullName:"Noboru Imai",slug:"noboru-imai"}]},{id:"13621",title:"Mass Transfers and Sedimentary Budgets in Geomorphologic Drainage Basin Studies",slug:"mass-transfers-and-sedimentary-budgets-in-geomorphologic-drainage-basin-studies",signatures:"Achim A. Beylich",authors:[{id:"16156",title:"Prof.",name:"Achim A.",middleName:null,surname:"Beylich",fullName:"Achim A. Beylich",slug:"achim-a.-beylich"}]},{id:"13622",title:"Successive Linearisation Solution of Free Convection Non-Darcy Flow with Heat and Mass Transfer",slug:"successive-linearisation-solution-of-free-convection-non-darcy-flow-with-heat-and-mass-transfer",signatures:"Sandile Motsa and Stanford Shateyi",authors:[{id:"16056",title:"Dr.",name:"Stanford",middleName:null,surname:"Shateyi",fullName:"Stanford Shateyi",slug:"stanford-shateyi"},{id:"18031",title:"Prof.",name:"Sandile",middleName:null,surname:"Motsa",fullName:"Sandile Motsa",slug:"sandile-motsa"}]},{id:"13623",title:"Explicit and Approximated Solutions for Heat and Mass Transfer Problems with a Moving Interface",slug:"explicit-and-approximated-solutions-for-heat-and-mass-transfer-problems-with-a-moving-interface",signatures:"Domingo Alberto Tarzia",authors:[{id:"18091",title:"Prof.",name:"Domingo",middleName:"Alberto",surname:"Tarzia",fullName:"Domingo Tarzia",slug:"domingo-tarzia"}]},{id:"13624",title:"Boundary Control Problems for Oberbeck-Boussinesq Model of Heat and Mass Transfer",slug:"boundary-control-problems-for-oberbeck-boussinesq-model-of-heat-and-mass-transfer",signatures:"Gennady Alekseev, Dmitry Tereshko and Vladislav Pukhnachev",authors:[{id:"16032",title:"Prof.",name:"Gennady",middleName:null,surname:"Alekseev",fullName:"Gennady Alekseev",slug:"gennady-alekseev"},{id:"19393",title:"Prof.",name:"Vladislav",middleName:null,surname:"Pukhnachev",fullName:"Vladislav Pukhnachev",slug:"vladislav-pukhnachev"},{id:"19394",title:"Dr.",name:"Dmitry",middleName:null,surname:"Tereshko",fullName:"Dmitry Tereshko",slug:"dmitry-tereshko"}]},{id:"13625",title:"Heat and Mass Transfer in Desiccant Wheels",slug:"heat-and-mass-transfer-in-desiccant-wheels",signatures:"Celestino Ruivo, José Costa and António Rui Figueiredo",authors:[{id:"20069",title:"Dr.",name:"Celestino",middleName:null,surname:"Ruivo",fullName:"Celestino Ruivo",slug:"celestino-ruivo"},{id:"20475",title:"Prof.",name:"José",middleName:null,surname:"Costa",fullName:"José Costa",slug:"jose-costa"},{id:"20476",title:"Prof.",name:"António Rui",middleName:null,surname:"Figueiredo",fullName:"António Rui Figueiredo",slug:"antonio-rui-figueiredo"}]},{id:"13626",title:"Oscillatory Regimes of Solutocapillary Marangoni Convection",slug:"oscillatory-regimes-of-solutocapillary-marangoni-convection",signatures:"Konstantin Kostarev, Andrew Zuev and Antonio Viviani",authors:[{id:"14946",title:"Dr.",name:"Antonio",middleName:null,surname:"Viviani",fullName:"Antonio Viviani",slug:"antonio-viviani"},{id:"18938",title:"Dr.",name:"Konstantin",middleName:null,surname:"Kostarev",fullName:"Konstantin Kostarev",slug:"konstantin-kostarev"},{id:"18939",title:"Dr.",name:"Andrew",middleName:null,surname:"Zuev",fullName:"Andrew Zuev",slug:"andrew-zuev"}]},{id:"13627",title:"Aerodynamics of Ceramic Regular Packing for Heat-Massexchenge 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Dziak",slug:"janusz-dziak"}]}]}],publishedBooks:[{type:"book",id:"36",title:"Heat Transfer",subtitle:"Mathematical Modelling, Numerical Methods and Information Technology",isOpenForSubmission:!1,hash:null,slug:"heat-transfer-mathematical-modelling-numerical-methods-and-information-technology",bookSignature:"Aziz Belmiloudi",coverURL:"https://cdn.intechopen.com/books/images_new/36.jpg",editedByType:"Edited by",editors:[{id:"17391",title:"Prof.",name:"Aziz",surname:"Belmiloudi",slug:"aziz-belmiloudi",fullName:"Aziz Belmiloudi"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"61",title:"Mass Transfer in Multiphase Systems and its Applications",subtitle:null,isOpenForSubmission:!1,hash:null,slug:"mass-transfer-in-multiphase-systems-and-its-applications",bookSignature:"Mohamed El-Amin",coverURL:"https://cdn.intechopen.com/books/images_new/61.jpg",editedByType:"Edited 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Applications",isOpenForSubmission:!1,hash:"7981cc291e9ee4ff4634384466570ec6",slug:"heat-and-mass-transfer-advances-in-modelling-and-experimental-study-for-industrial-applications",bookSignature:"Yong Ren",coverURL:"https://cdn.intechopen.com/books/images_new/6652.jpg",editedByType:"Edited by",editors:[{id:"177059",title:"Dr.",name:"Yong",surname:"Ren",slug:"yong-ren",fullName:"Yong Ren"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}}]},onlineFirst:{chapter:{type:"chapter",id:"73275",title:"Neutrophil Gelatinase-Associated Lipocalin as a Promising Biomarker in Acute Kidney Injury",doi:"10.5772/intechopen.93650",slug:"neutrophil-gelatinase-associated-lipocalin-as-a-promising-biomarker-in-acute-kidney-injury",body:'Acute kidney injury (AKI) is a frequent complication in several clinical settings, including large surgeries [1], emergency departments [2, 3], and intensive care units (ICUs) [4]. The incidence of AKI has been increasing over the years, with about 2 million people being affected in 2010 [5], despite the efforts of researchers and organizations [6, 7, 8]. AKI is commonly followed by worse outcomes: prolonged length of ICU and hospital stay, need for dialysis, decreases in the glomerular filtration rate (GRF), development of chronic kidney disease (CKD), and increases in mortality [9, 10, 11].
In recent decades, therapeutic interventions aimed at reversing kidney dysfunction have had disappointing results in multiple settings; thus, the research focus has shifted from treatment to prevention and early detection by focusing on two main issues: diagnostic criteria and early diagnosis. In 2004, the Acute Dialysis Quality Initiative (ADQI) sought a more uniform definition of AKI, and the most recent consensus definition was published in 2012 by Kidney Disease: Improving Global Outcomes (KDIGO) [8]. The diagnosis of AKI is based on changes in serum creatinine (Scr) and urine output (UO), but neither marker is kidney specific. Efforts have been made to identify novel biomarkers that have high sensitivity and specificity.
The standardization of the diagnosis of AKI allowed us to compare the diagnoses made in different settings. However, the issue of early diagnosis is still a challenge. First, there are limitations regarding the use of Scr and UO. Second, determining the need for renal replacement therapy is difficult due to a lack of information about whether the AKI is transient or persistent. Last, the research advances identifying early biomarkers have thus far been inaccessible in clinical practice [12].
Neutrophil gelatinase-associated lipocalin (NGAL) [13] has been far and away the most promising biomarker to help fill this gap, and its diagnostic capabilities as a biomarker have been confirmed in a large number of clinical trials. This chapter aims to present information on the role of NGAL in the renal injury process, its expression in the kidney, confounding factors, the type of assay used, whether plasma or urine NGAL has better accuracy, the cutoff values in normal individuals, the accuracy of NGAL for diagnosing AKI, and the evaluation of other outcomes.
In 1993, Kjeldsen et al. [13] isolated lipocalin as a protease-resistant polypeptide covalently bound to neutrophil gelatinase, named neutrophil gelatinase-associated lipocalin (NGAL), also known as siderocalin, lipocalin 2 or oncogene 24p [14].
NGAL is a 25 kilodalton (kDa) protein covalently bound to gelatinase in neutrophil-specific granules. NGAL is expressed at very low levels in various human tissues, including the kidneys, uterus, prostate, salivary gland, trachea, lungs, stomach, and adult and fetal colon [15, 16]. The anti-inflammatory function of NGAL is demonstrated by increased NGAL expression in proliferative epithelia, inflammatory areas, and intestinal malignancies [17].
In normal kidneys, the expression of NGAL is mainly released by the thick ascending limb and the intercalated cells of the thick collecting duct. Some NGAL expression is also present in the proximal tubular epithelium, once NGAL is filtered by the glomerulus and reabsorbed by the proximal tubule in a megalin-dependent manner [17, 18]. The physiological function of NGAL in the kidneys is unknown; however, the role of NGAL in renal morphogenesis is under consideration [19]. NGAL also has a predominant role in the regulation of cell proliferation, repair processes, and tubular reepithelization. NGAL expression corresponds to an additional iron transport pathway, which increases the transcription of hemeoxygenase, an enzyme with proliferative and antiapoptotic effects that protects and preserves proximal tubular cells [20, 21].
Several biological functions for NGAL have been suggested; in the kidney, NGAL release is associated with ischemic or nephrotoxic insults. Additionally, a decrease in tubular reabsorption after AKI may lead to a further increase in urinary NGAL concentration, resulting acquiring a status of the “troponin” of the kidneys [22, 23, 24].
The conditions that can interfere with the performance, sensitivity, and specificity of NGAL, already identified as a biomarker, are sepsis, chronic obstructive pulmonary disease, and cardiac dysfunction, and the presence of these conditions may act as confounding factors for NGAL measurements. The predictive performance of NGAL seems to also be influenced by age (higher predictive value in children than in older patients), sex (higher predictive value in female patients than in male patients), urinary tract infection, and impaired renal function (higher predictive value in patients with chronic kidney disease) [25, 26, 27].
Sepsis will be more thoroughly addressed in the next chapter.
The commercialization of NGAL as the gold standard for the diagnosis of AKI is somewhat controversial [28]. There are many types of NGAL assays available on the market that use different nonautomated ELISA platforms, which makes it difficult for comparisons to be made among studies from around the world.
The first kit for the quantitative and automated determination of NGAL by the ELISA method was developed by Abbott Laboratories (Abbott Park, IL, USA) for the urinary evaluation of NGAL, with a cutoff value of 141 μg/L (95% CI 125–158 μg/L). An EDTA plasma blood test was created by the Triage Meter platform (Biosite-Inverness Medical, Waltham, USA) with a cutoff value of 163 μ/L (CI 109–221 μ/L) [29].
Bioporto (Bioporto Diagnostics A/S, Gentfte, Denmark) developed a new particle-enhanced turbidimetric immunoassay (PETIA) that has the advantages of flexibility (adaptation for clinical use in different analyzers), automation (closer to clinical practice), and applicability in different biological matrices (urine and plasma) [30].
The chemiluminescence test is an alternative to assess NGAL, and it is commonly used to analyze studies with small animals since it is possible to do the analysis with few substrates [31].
Because there are three known molecular forms of NGAL, the assay of interest should differentiate the 25 kDa NGAL monomer produced by the monocyte tubular epithelial cells from other forms of NGAL: 45 kDa NGAL, from the homodimer predominantly secreted by neutrophils, and the 145 kDa NGAL/matrix metalloproteinase-9 (MMP9) covalently complexed heterodimer [32, 33].
According to Mårtensson et al. [34] and Cai et al. [33], the combination of two ELISAs, may improve the diagnostic accuracy of NGAL, one to determine the monomeric form and the other to determine the homodimeric form.
The confounding factor of sepsis is described herein and is dependent on the assay method, as well as whether the chosen kit is less sensitive to 25 kDa NGAL expressed by tubular epithelial cells. The test can also measure the 45 kDa homodimer predominantly secreted by neutrophils, which are common in sepsis, and the increase in neutrophils increases homodimeric NGAL expression and results in false positives.
The consensus is clear that NGAL measured in urine has better performance [35], because the release and increase in NGAL will occur first in urine. However, the collection of urine depends on the urine output, which is sometimes not available. Some benefits of plasma NGAL are that it is available at any time and is more accurate in anuric or oliguric patients.
The issue about the normalization of urinary NGAL by correction for the urinary creatinine level is debatable, but it has been used to correct for urine output in cases of oliguria or pollakiuria, avoiding inaccurate concentration or dilution measurements of the biomarkers. The fact is that the creatinine release time is different from the biomarker release time, and the normalized level will be affected by this difference and will not represent a real physiological value [36].
The determination of normal NGAL levels in healthy adults has been inadequately described in the literature. However, some studies have been performed, such as that of Cullen et al. [26], which analyzed urine by the Abbot-Architec assay in 174 healthy people (100 men and 74 women aged between 19 and 88 years). The value of the immunoassay result was normalized by urinary creatinine, and the cut-off value was 107 μ/mmol (13 μ/mmol). There was a higher concentration of creatinine-normalized urinary NGAL in women, in the elderly and in patients with leukocyturia.
The study reported by Stejkal et al. [37] analyzed BioVendor’s NGAL assay using the serum of 136 healthy, nonobese individuals (53 men and 83 women). The authors reported median NGAL values (78.8 μg/L for men and 80 μg/L for women). Pernnemans et al. [27] analyzed the NGAL ELISA (RD System Europe, Abingdon, UK) and other urinary biomarkers in 338 healthy individuals (199 women and 139 men, aged 0 to 95 years). They reported that the NGAL reference range of the 21–95 years age group was 73.88–211.16 μg/L in women and 149.26–182.58 μg/L in men, and there was higher expression in elderly individuals.
An NGAL PETIA (Bioporto Diagnostics A/S, Gentfte, Denmark) [36] was evaluated for 200 healthy nonobese individuals (137 men and 63 women, with a mean age of 39 years (SD 11.2)). They proposed reference plasma concentrations from 38.7–157.6 ng/ml for women and 24.4–142.5 ng/ml for men and proposed reference urine concentrations of <9–54.5 ng/ml for both sexes. The authors reported that the mean values in men were higher than in women, 78.9 ng/ml vs. 73.8 ng/ml, respectively; there was a significant difference in NGAL in relation to age.
In addition to the variability of the chosen immunoassay, the unit of measurement in the interpretation of the NGAL studies should be considered—the most commonly found are ng/ml, μg/L, ng/dl, mg/ml and μg/mmol.
NGAL is the most widely investigated AKI biomarker. Its performance for predicting AKI has been evaluated in various settings, such as in pediatric and adult cardiac surgery patients, in critically ill patients, and in patients in the emergency room, as well in kidney transplant and other settings [38, 39].
Numerous studies have demonstrated the ability of NGAL to diagnose AKI. For example, the study reported by Constantin et al. [40], that evaluated the plasma NGAL of 88 patients at ICU admission, found a sensitivity of 82%, specificity of 97% and AUC of 0.92 to cut-off value of 155 mmol/L to predictor of AKI.
A multicenter study, reported by Di Somma et al. [41], with 665 patients admitted to the emergency department, assessed plasma NGAL in several points after admission. Serial evaluation of NGAL at times zero and six hours provided a high negative predictive value (NPV) (98%) to rule out the diagnosis of AKI within six hours of the arrival of patients to the emergency department. The NGAL value at admission could demonstrated a strong predictive value for in-hospital mortality of the patient, with a cut-off value of 400 ng/ml.
In the meta-analysis by Haase et al. [42]—with 19 studies, totaling 2538 patients, of whom 487 (19.2%) developed AKI—NGAL was demonstrated to have diagnostic and prognostic value for AKI, with an OR of 18.6 (95% CI 9–38.1) and AUC of 0.81 (95% CI 0.73–0.89). The cut-off value ranged from 100 to 270 ng/ml, but a value of 150 ng/dl was suggested for the diagnosis of AKI.
In another recent meta-analysis by Zhou et al. [39]—with 24 studies, a total of 4066 patients from 9 countries, including studies with serum and urinary NGAL—the sensitivity for the diagnosis of AKI was 0.68 (95% CI, 65–0.70), and the specificity was 0.79 (95% CI 0.77–0.80).
In the study by Singer et al. [38], urinary NGAL was useful for classifying and stratifying patients with established AKI: the level of NGAL>104 μg/L indicated intrinsic AKI (odds ratio of 5.97), while the level of NGAL <47 μg/L indicated unlikely intrinsic AKI (odds ratio of 0.2). In the logistic regression analysis, NGAL was able to predict the worsening of the RIFLE class, the need for RRT and in-hospital mortality. The performance of NGAL to evaluate other outcomes will be discussed in the next chapter.
The study by Bennett et al. [43] clearly indicated that urinary NGAL is a powerful early biomarker of AKI after cardiopulmonary bypass that preceded the increase in serum creatinine by 2–3 days. Studies have shown that elevation of NGAL is detectable after 3 hours and peaks approximately 6–12 hours after injury. The elevation can persist up to 5 days according to the severity of injury [44, 45, 46]. In addition to Benett’s study, other studies in general have failed to reach conclusions about the early timing diagnosis of NGAL, which is the main finding required to reach a therapeutic window and better evaluate future medication targets in AKI.
Several studies have assessed the diagnostic value of NGAL to predict AKI, but only a few have analyzed the early diagnosis in hours/days and compared it with serum creatinine, as seen in the last chapter. Still fewer studies have evaluated the predictive performance of NGAL in other outcomes, such as the need for RRT, recovery of renal function, progression to end stage renal disease (ESRD) and mortality, which will be discussed in this chapter.
In the meta-analysis by Hall et al. [47], for 91 kidney transplant patients, the incidence of need for RRT was 4.3%, and NGAL, in this scenario, had an OR of 12.9 and AUC of 0.78. In the same study, NGAL and urinary IL18 were predictors of the need for RRT up to 1 week after transplantation. NGAL presented a good AUC of 0.81 (95% CI 0.70–0.92) 6 hours after transplantation and was also a predictor of graft recovery for up to 3 months.
In the study conducted by Constantin et al. [40], the cutoff value of NGAL to assess the need for RRT was 330 mmol/L. The value of urinary NGAL (Architect, Abbot Park, IL) was correlated with the need for dialysis (r: 0.48 P: 0.01), presenting an AUC of 0.86 2 hours after cardiopulmonary bypass in children [43].
A recent meta-analysis by Klein et al. analyzed 12 studies to predict the need for RRT and found an AUC of 0.70 (95% CI 0.63–0.80) for NGAL [48].
Bhavsar et al. [49] concluded that higher levels of NGAL (measured by the Luminex assay) were associated with stage 3 CKD incidence. Some researchers have discussed whether the association of NGAL level is not exclusively related to the increase in neutrophils already described by Tian et al. [50] and maintain that further studies would be needed to elucidate this issue.
In the meta-analysis by Haase et al. [42], the incidence of mortality was 5.4%, and NGAL, in this scenario, showed an OR of 8.8 and AUC of 0.70.
In the Ariza study [51], PNGAL and UNGAL were demonstrated to be strong predictors of prognosis, and UNGAL was significantly predictive of the MELD score using the 28-day mortality score AUC of 0.88 (0.83–0.92).
In the study by Bennett et al. [43], the value of urinary NGAL (Architect, Abbot Park, IL) was also correlated with mortality (r: 0.53 p 0.01), with an AUC of 0.91, 2 hours after cardiopulmonary bypass in children.
The study by Dent et al. [52], using PNGAL (Biosite Inc., San Diego, USA) in 120 children undergoing cardiopulmonary bypass (CBP) and a cut-off value of 150 ng/ml and AKI prediction, found an AUC of 0.96 2 hours after CBP. PNGAL was also strongly correlated with the duration of AKI (r = 0.57, p < 0.001) and hospital stay time (r = 0.44, p < 0.001), and PNGAL at 12 hours was correlated with mortality (r = 0.48, p: 0.004).
In the study by Daniels et al. [53], PNGAL (Alere Inc., Waltham, USA) was measured in 1393 adult patients with cardiovascular disease (CVD) who were followed for 11 years. Of these, 436 did not survive, and 169 died from CVD. PNGAL was a predictor of CVD mortality, with a risk ratio of 1.33% and a risk ratio of 1.19% for all causes of mortality.
This brief review, based on accumulated evidence, discussed the role and value of NGAL in the diagnosis and prognosis of AKI. Studies’ findings suggest that induction of NGAL plays an important role in kidney function preservation, reducing apoptosis, and enhancing proliferative responses. In kidney injury, rapid and massive upregulated synthesis of NGAL occurs in the distal tubule, which quickly increases the concentration of NGAL in urine [54]. In addition, other important considerations have been provided as “key point” to help researchers move the NGAL analysis to clinical practice as soon possible.
The authors declare that there are no conflicts of interest regarding the publication of this chapter.
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Due to its advantages of abundant resources, less in cost, great workability and high physical properties, fly ash leads to achieving high mechanical properties. Fly ash is considered as one of the largest generated industrial solid wastes or so-called industrial by-products, around the world particularly in China, India, and USA. The characteristics of fly ash allow it to be a geotechnical material to produce geopolymer cement or concrete as an alternative of ordinary Portland cement. Many efforts are made in this direction to formulate a suitable mix design of fly ash-based geopolymer by focusing on fly ash as the main prime material. The physical properties, chemical compositions, and chemical activation of fly ash are analyzed and evaluated in this review paper. Reference has been made to different ASTM, ACI standards, and other researches work in geopolymer area.",book:{id:"9916",slug:"zero-energy-buildings-new-approaches-and-technologies",title:"Zero-Energy Buildings",fullTitle:"Zero-Energy Buildings - New Approaches and Technologies"},signatures:"Aissa Bouaissi, Long Yuan Li, Mohd Mustafa Al Bakri Abdullah, Romisuhani Ahmad, Rafiza Abdul Razak and Zarina Yahya",authors:null},{id:"73729",doi:"10.5772/intechopen.93500",title:"Solar Energy and Its Purpose in Net-Zero Energy Building",slug:"solar-energy-and-its-purpose-in-net-zero-energy-building",totalDownloads:603,totalCrossrefCites:3,totalDimensionsCites:5,abstract:"The Net Zero Energy Building is generally described as an extremely energy-efficient building in which the residual electricity demand is provided by renewable energy. Solar power is also regarded to be the most readily available and usable form of renewable electricity produced at the building site. In contrast, energy conservation is viewed as an influential national for achieving a building’s net zero energy status. This chapter aims to show the value of the synergy between energy conservation and solar energy transfer to NZEBs at the global and regional levels. To achieve these goals, both energy demand building and the potential supply of solar energy in buildings have been forecasted in various regions, climatic conditions, and types of buildings. Building energy consumption was evaluated based on a bottom-up energy model developed by 3CSEP and data inputs from the Bottom-Up Energy Analysis System (BUENAS) model under two scenarios of differing degrees of energy efficiency intention. The study results indicate that the acquisition of sustainable energy consumption is critical for solar-powered net zero energy buildings in various building styles and environments. The chapter calls for the value of government measures that incorporate energy conservation and renewable energy.",book:{id:"9916",slug:"zero-energy-buildings-new-approaches-and-technologies",title:"Zero-Energy Buildings",fullTitle:"Zero-Energy Buildings - New Approaches and Technologies"},signatures:"Mostafa Esmaeili Shayan",authors:[{id:"317852",title:"Ph.D.",name:"Mostafa",middleName:null,surname:"Esmaeili Shayan",slug:"mostafa-esmaeili-shayan",fullName:"Mostafa Esmaeili Shayan"}]},{id:"67105",doi:"10.5772/intechopen.86279",title:"Social Innovation and Environmental Sustainability in Social Housing Policies: Learning from Two Experimental Case Studies in Italy",slug:"social-innovation-and-environmental-sustainability-in-social-housing-policies-learning-from-two-expe",totalDownloads:1011,totalCrossrefCites:2,totalDimensionsCites:4,abstract:"This chapter critically examines approaches and solutions developed by social housing to sustainably respond to the housing emergency plaguing contemporary cities and Italian cities in particular. In a broader perspective, we also investigate how housing has become ‘difficult’ in Europe and the poorest segments of the population run the risk of having their right to housing dramatically denied. Analysing housing in terms of its procedural dimension, we focus on two Italian case studies that evoke a new way of inhabiting the city, cases in which high standards characterised social housing and yet remain accessible to all. The Sharing hotel residence in Turin and Zoia social housing in Milan combine housing with other socially innovative measures in a framework of sustainability and avant-garde construction. These are significant examples that speak to issues such as temporariness, flexibility and the coordination of measures. These two cases both pursued objectives having to do with social, planning, architectural and environmental quality, albeit each in their own way. There are by now numerous examples of social housing in Europe and these have recently attracted growing interest in Italy as well; in this country, however, such projects represent valid instances of experimentation but are not at all widespread.",book:{id:"7650",slug:"different-strategies-of-housing-design",title:"Different Strategies of Housing Design",fullTitle:"Different Strategies of Housing Design"},signatures:"Rossana Galdini and Silvia Lucciarini",authors:[{id:"281246",title:"Dr.",name:"Silvia",middleName:null,surname:"Lucciarini",slug:"silvia-lucciarini",fullName:"Silvia Lucciarini"},{id:"282958",title:"Prof.",name:"Rossana",middleName:null,surname:"Galdini",slug:"rossana-galdini",fullName:"Rossana Galdini"}]},{id:"67084",doi:"10.5772/intechopen.86278",title:"Comprehensive Strategy for Sustainable Housing Design",slug:"comprehensive-strategy-for-sustainable-housing-design",totalDownloads:1362,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Sustainable housing needs to be designed to maximize occupants’ well-being and minimize the environmental load. The pursuit of combining these two different aspects toward sustainability is a goal-oriented task. The science of control can be applied to all goal-oriented tasks. Therefore, applying control science, we have been progressing in research on sustainable housing design. Our previous study has produced the control system for promoting sustainable housing design in which sustainable design guidelines and sustainability checklist are incorporated. Based on these accomplished results, this study has comprehensively visualized the process of producing and revising the sustainable design guidelines and sustainability checklist. Following this visualized process, also this study has concretely shown the production and revision processes of the sustainable design guidelines. The study results suggest that the comprehensive visualization can make these processes more manageable and help system designers to produce and revise the guidelines more efficiently. Furthermore, these results have led to indicating how to adjust the guidelines to different countries or regions as well as changing situations over time.",book:{id:"7650",slug:"different-strategies-of-housing-design",title:"Different Strategies of Housing Design",fullTitle:"Different Strategies of Housing Design"},signatures:"Kazutoshi Fujihira",authors:[{id:"69662",title:"BSc.",name:"Kazutoshi",middleName:null,surname:"Fujihira",slug:"kazutoshi-fujihira",fullName:"Kazutoshi Fujihira"}]},{id:"57401",doi:"10.5772/intechopen.71325",title:"Basic Schemes: Preparations for Applying Control Science to Sustainable Design",slug:"basic-schemes-preparations-for-applying-control-science-to-sustainable-design",totalDownloads:1223,totalCrossrefCites:3,totalDimensionsCites:3,abstract:"It is the ultimate goal for humankind to deal with various problems and achieve sustainability. Control science can be applied to all goal-oriented tasks and has already produced remarkable results. Accordingly, applying control science to the task of achieving sustainability is a rational and reliable approach. In order to apply control science to sustainability issues, our first study has shown the “basic control system for sustainability” as well as the “model of sustainability.” After that, in order to identify system components of practical control systems for promoting sustainable design, we have devised “two-step preparatory work for sustainable design.” The two steps of this preparatory work are “determining the relationships between the standard human activities and sustainability” and “sustainability checkup on human activities as an object.”",book:{id:"5692",slug:"sustainable-home-design-by-applying-control-science",title:"Sustainable Home Design by Applying Control Science",fullTitle:"Sustainable Home Design by Applying Control Science"},signatures:"Kazutoshi Fujihira",authors:[{id:"69662",title:"BSc.",name:"Kazutoshi",middleName:null,surname:"Fujihira",slug:"kazutoshi-fujihira",fullName:"Kazutoshi Fujihira"}]}],mostDownloadedChaptersLast30Days:[{id:"71982",title:"Net-Zero Energy Buildings: Principles and Applications",slug:"net-zero-energy-buildings-principles-and-applications",totalDownloads:2226,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"Global warming and climate change are rising issues during the last couple of decades. With residential and commercial buildings being the largest energy consumers, sources are being depleted at a much faster pace in the recent decades. Recent statistics shows that 14% of humans are active participant to protect the environment with an additional 48% sympathetic but not active. In this chapter, net-zero energy buildings design tools and applications are presented that can help designers in the commercial and residential sectors design their buildings to be net-zero energy buildings. Case studies with benefits and challenges will be presented to illustrate the different designs to achieve a net-zero energy building (NZEB).",book:{id:"9916",slug:"zero-energy-buildings-new-approaches-and-technologies",title:"Zero-Energy Buildings",fullTitle:"Zero-Energy Buildings - New Approaches and Technologies"},signatures:"Maher Shehadi",authors:null},{id:"57400",title:"Case Study: Detached House Designed by Following the Control System",slug:"case-study-detached-house-designed-by-following-the-control-system",totalDownloads:1548,totalCrossrefCites:2,totalDimensionsCites:2,abstract:"The previous chapter has demonstrated the control system for promoting sustainable housing design in which the sustainable design guidelines and sustainability checklist are incorporated. Following this control system, we have actually designed and constructed a detached house. To be concrete, the homeowner and the architects of the housing manufacture have designed the home’s parts, or elements, so that as much as possible the elements’ variables meet their desired values. The sustainable design guidelines and sustainability checklist have been readily accepted because the material and spatial elements are equivalent to real parts of the home. After the home started to be used, we have obtained external evaluations of the home’s sustainability performance. For example, CASBEE for Detached Houses, a comprehensive assessment system, has readily ranked the house in the highest “S.” An energy-saving performance assessment has shown that this home has reduced energy consumption by over 70%, as compared with the average home. On the other hand, the reactions of the occupants and visitors have indicated the comfort, healthiness and safety of this house. Furthermore, this home has received a sustainable housing award, especially due to its extremely high sustainability and energy-saving performance.",book:{id:"5692",slug:"sustainable-home-design-by-applying-control-science",title:"Sustainable Home Design by Applying Control Science",fullTitle:"Sustainable Home Design by Applying Control Science"},signatures:"Kazutoshi Fujihira",authors:[{id:"69662",title:"BSc.",name:"Kazutoshi",middleName:null,surname:"Fujihira",slug:"kazutoshi-fujihira",fullName:"Kazutoshi Fujihira"}]},{id:"67084",title:"Comprehensive Strategy for Sustainable Housing Design",slug:"comprehensive-strategy-for-sustainable-housing-design",totalDownloads:1362,totalCrossrefCites:2,totalDimensionsCites:3,abstract:"Sustainable housing needs to be designed to maximize occupants’ well-being and minimize the environmental load. The pursuit of combining these two different aspects toward sustainability is a goal-oriented task. The science of control can be applied to all goal-oriented tasks. Therefore, applying control science, we have been progressing in research on sustainable housing design. Our previous study has produced the control system for promoting sustainable housing design in which sustainable design guidelines and sustainability checklist are incorporated. Based on these accomplished results, this study has comprehensively visualized the process of producing and revising the sustainable design guidelines and sustainability checklist. Following this visualized process, also this study has concretely shown the production and revision processes of the sustainable design guidelines. The study results suggest that the comprehensive visualization can make these processes more manageable and help system designers to produce and revise the guidelines more efficiently. Furthermore, these results have led to indicating how to adjust the guidelines to different countries or regions as well as changing situations over time.",book:{id:"7650",slug:"different-strategies-of-housing-design",title:"Different Strategies of Housing Design",fullTitle:"Different Strategies of Housing Design"},signatures:"Kazutoshi Fujihira",authors:[{id:"69662",title:"BSc.",name:"Kazutoshi",middleName:null,surname:"Fujihira",slug:"kazutoshi-fujihira",fullName:"Kazutoshi Fujihira"}]},{id:"65804",title:"Effects of Street Geometry on Airflow Regimes for Natural Ventilation in Three Different Street Configurations in Enugu City",slug:"effects-of-street-geometry-on-airflow-regimes-for-natural-ventilation-in-three-different-street-conf",totalDownloads:1401,totalCrossrefCites:1,totalDimensionsCites:3,abstract:"Efficient natural ventilation is dependent on the micro climate conditions of an urban environment. This is affected by ambient wind flow, radiation and air temperatures. The airflow within the urban street can be cultivated into two regions. The first is a recirculation region, which forms in the near wake of each building. The Second is a ventilated region downstream of the recirculation region, formed when the street is sufficiently wide. The development of the flow into these two regions depends on geometry. This chapter looks at the impacts of street geometry on these regions of airflow cultivation in three different street configurations in high density residential settlements in Enugu city. It utilized schematic analysis of airflow regimes to identify the behaviors of flow in these street configurations relative to the height and width ratios of the street canyon. This schematic analysis can be utilized in preliminary design studies by city and building designers for justifying street dimensions and configurations in tropical regions where natural ventilation is paramount.",book:{id:"7650",slug:"different-strategies-of-housing-design",title:"Different Strategies of Housing Design",fullTitle:"Different Strategies of Housing Design"},signatures:"Jideofor Anselm Akubue",authors:[{id:"139659",title:"Dr.",name:"Akubue",middleName:"Jideofor",surname:"Anselm",slug:"akubue-anselm",fullName:"Akubue Anselm"}]},{id:"66000",title:"Fundamentals of Natural Ventilation Design within Dwellings",slug:"fundamentals-of-natural-ventilation-design-within-dwellings",totalDownloads:962,totalCrossrefCites:0,totalDimensionsCites:0,abstract:"Along with acoustical and lighting comfort, indoor air quality (IAQ) and thermal comfort upon households are essential to maintain a proper indoor environment, therefore ensuring a welfare toward the occupants. 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Saxena",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRET3QAO/Profile_Picture_2022-05-10T10:10:26.jpeg",institutionString:"King George's Medical University",institution:{name:"King George's Medical University",institutionURL:null,country:{name:"India"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null}]},subseriesFiltersForPublishedBooks:[{group:"subseries",caption:"Bacterial Infectious Diseases",value:3,count:2},{group:"subseries",caption:"Parasitic Infectious Diseases",value:5,count:4},{group:"subseries",caption:"Viral Infectious Diseases",value:6,count:7}],publicationYearFilters:[{group:"publicationYear",caption:"2022",value:2022,count:2},{group:"publicationYear",caption:"2021",value:2021,count:4},{group:"publicationYear",caption:"2020",value:2020,count:3},{group:"publicationYear",caption:"2019",value:2019,count:3},{group:"publicationYear",caption:"2018",value:2018,count:1}],authors:{paginationCount:250,paginationItems:[{id:"274452",title:"Dr.",name:"Yousif",middleName:"Mohamed",surname:"Abdallah",slug:"yousif-abdallah",fullName:"Yousif Abdallah",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/274452/images/8324_n.jpg",biography:"I certainly enjoyed my experience in Radiotherapy and Nuclear Medicine, particularly it has been in different institutions and hospitals with different Medical Cultures and allocated resources. Radiotherapy and Nuclear Medicine Technology has always been my aspiration and my life. As years passed I accumulated a tremendous amount of skills and knowledge in Radiotherapy and Nuclear Medicine, Conventional Radiology, Radiation Protection, Bioinformatics Technology, PACS, Image processing, clinically and lecturing that will enable me to provide a valuable service to the community as a Researcher and Consultant in this field. My method of translating this into day to day in clinical practice is non-exhaustible and my habit of exchanging knowledge and expertise with others in those fields is the code and secret of success.",institutionString:null,institution:{name:"Majmaah University",country:{name:"Saudi Arabia"}}},{id:"313277",title:"Dr.",name:"Bartłomiej",middleName:null,surname:"Płaczek",slug:"bartlomiej-placzek",fullName:"Bartłomiej Płaczek",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/313277/images/system/313277.jpg",biography:"Bartłomiej Płaczek, MSc (2002), Ph.D. (2005), Habilitation (2016), is a professor at the University of Silesia, Institute of Computer Science, Poland, and an expert from the National Centre for Research and Development. His research interests include sensor networks, smart sensors, intelligent systems, and image processing with applications in healthcare and medicine. He is the author or co-author of more than seventy papers in peer-reviewed journals and conferences as well as the co-author of several books. He serves as a reviewer for many scientific journals, international conferences, and research foundations. Since 2010, Dr. Placzek has been a reviewer of grants and projects (including EU projects) in the field of information technologies.",institutionString:"University of Silesia",institution:{name:"University of Silesia",country:{name:"Poland"}}},{id:"35000",title:"Prof.",name:"Ulrich H.P",middleName:"H.P.",surname:"Fischer",slug:"ulrich-h.p-fischer",fullName:"Ulrich H.P Fischer",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/35000/images/3052_n.jpg",biography:"Academic and Professional Background\nUlrich H. P. has Diploma and PhD degrees in Physics from the Free University Berlin, Germany. He has been working on research positions in the Heinrich-Hertz-Institute in Germany. Several international research projects has been performed with European partners from France, Netherlands, Norway and the UK. He is currently Professor of Communications Systems at the Harz University of Applied Sciences, Germany.\n\nPublications and Publishing\nHe has edited one book, a special interest book about ‘Optoelectronic Packaging’ (VDE, Berlin, Germany), and has published over 100 papers and is owner of several international patents for WDM over POF key elements.\n\nKey Research and Consulting Interests\nUlrich’s research activity has always been related to Spectroscopy and Optical Communications Technology. Specific current interests include the validation of complex instruments, and the application of VR technology to the development and testing of measurement systems. He has been reviewer for several publications of the Optical Society of America\\'s including Photonics Technology Letters and Applied Optics.\n\nPersonal Interests\nThese include motor cycling in a very relaxed manner and performing martial arts.",institutionString:null,institution:{name:"Charité",country:{name:"Germany"}}},{id:"341622",title:"Ph.D.",name:"Eduardo",middleName:null,surname:"Rojas Alvarez",slug:"eduardo-rojas-alvarez",fullName:"Eduardo Rojas Alvarez",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/341622/images/15892_n.jpg",biography:null,institutionString:null,institution:{name:"University of Cuenca",country:{name:"Ecuador"}}},{id:"215610",title:"Prof.",name:"Muhammad",middleName:null,surname:"Sarfraz",slug:"muhammad-sarfraz",fullName:"Muhammad Sarfraz",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/215610/images/system/215610.jpeg",biography:"Muhammad Sarfraz is a professor in the Department of Information Science, Kuwait University. His research interests include computer graphics, computer vision, image processing, machine learning, pattern recognition, soft computing, data science, intelligent systems, information technology, and information systems. Prof. Sarfraz has been a keynote/invited speaker on various platforms around the globe. He has advised various students for their MSc and Ph.D. theses. He has published more than 400 publications as books, journal articles, and conference papers. He is a member of various professional societies and a chair and member of the International Advisory Committees and Organizing Committees of various international conferences. Prof. Sarfraz is also an editor-in-chief and editor of various international journals.",institutionString:"Kuwait University",institution:{name:"Kuwait University",country:{name:"Kuwait"}}},{id:"32650",title:"Prof.",name:"Lukas",middleName:"Willem",surname:"Snyman",slug:"lukas-snyman",fullName:"Lukas Snyman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/32650/images/4136_n.jpg",biography:"Lukas Willem Snyman received his basic education at primary and high schools in South Africa, Eastern Cape. He enrolled at today's Nelson Metropolitan University and graduated from this university with a BSc in Physics and Mathematics, B.Sc Honors in Physics, MSc in Semiconductor Physics, and a Ph.D. in Semiconductor Physics in 1987. After his studies, he chose an academic career and devoted his energy to the teaching of physics to first, second, and third-year students. After positions as a lecturer at the University of Port Elizabeth, he accepted a position as Associate Professor at the University of Pretoria, South Africa.\r\n\r\nIn 1992, he motivates the concept of 'television and computer-based education” as means to reach large student numbers with only the best of teaching expertise and publishes an article on the concept in the SA Journal of Higher Education of 1993 (and later in 2003). The University of Pretoria subsequently approved a series of test projects on the concept with outreach to Mamelodi and Eerste Rust in 1993. In 1994, the University established a 'Unit for Telematic Education ' as a support section for multiple faculties at the University of Pretoria. In subsequent years, the concept of 'telematic education” subsequently becomes well established in academic circles in South Africa, grew in popularity, and is adopted by many universities and colleges throughout South Africa as a medium of enhancing education and training, as a method to reaching out to far out communities, and as a means to enhance study from the home environment.\r\n\r\nProfessor Snyman in subsequent years pursued research in semiconductor physics, semiconductor devices, microelectronics, and optoelectronics.\r\n\r\nIn 2000 he joined the TUT as a full professor. Here served for a period as head of the Department of Electronic Engineering. Here he makes contributions to solar energy development, microwave and optoelectronic device development, silicon photonics, as well as contributions to new mobile telecommunication systems and network planning in SA.\r\n\r\nCurrently, he teaches electronics and telecommunications at the TUT to audiences ranging from first-year students to Ph.D. level.\r\n\r\nFor his research in the field of 'Silicon Photonics” since 1990, he has published (as author and co-author) about thirty internationally reviewed articles in scientific journals, contributed to more than forty international conferences, about 25 South African provisional patents (as inventor and co-inventor), 8 PCT international patent applications until now. Of these, two USA patents applications, two European Patents, two Korean patents, and ten SA patents have been granted. A further 4 USA patents, 5 European patents, 3 Korean patents, 3 Chinese patents, and 3 Japanese patents are currently under consideration.\r\n\r\nRecently he has also published an extensive scholarly chapter in an internet open access book on 'Integrating Microphotonic Systems and MOEMS into standard Silicon CMOS Integrated circuitry”.\r\n\r\nFurthermore, Professor Snyman recently steered a new initiative at the TUT by introducing a 'Laboratory for Innovative Electronic Systems ' at the Department of Electrical Engineering. The model of this laboratory or center is to primarily combine outputs as achieved by high-level research with lower-level system development and entrepreneurship in a technical university environment. Students are allocated to projects at different levels with PhDs and Master students allocated to the generation of new knowledge and new technologies, while students at the diploma and Baccalaureus level are allocated to electronic systems development with a direct and a near application for application in industry or the commercial and public sectors in South Africa.\r\n\r\nProfessor Snyman received the WIRSAM Award of 1983 and the WIRSAM Award in 1985 in South Africa for best research papers by a young scientist at two international conferences on electron microscopy in South Africa. He subsequently received the SA Microelectronics Award for the best dissertation emanating from studies executed at a South African university in the field of Physics and Microelectronics in South Africa in 1987. In October of 2011, Professor Snyman received the prestigious Institutional Award for 'Innovator of the Year” for 2010 at the Tshwane University of Technology, South Africa. This award was based on the number of patents recognized and granted by local and international institutions as well as for his contributions concerning innovation at the TUT.",institutionString:null,institution:{name:"University of South Africa",country:{name:"South Africa"}}},{id:"317279",title:"Mr.",name:"Ali",middleName:"Usama",surname:"Syed",slug:"ali-syed",fullName:"Ali Syed",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/317279/images/16024_n.png",biography:"A creative, talented, and innovative young professional who is dedicated, well organized, and capable research fellow with two years of experience in graduate-level research, published in engineering journals and book, with related expertise in Bio-robotics, equally passionate about the aesthetics of the mechanical and electronic system, obtained expertise in the use of MS Office, MATLAB, SolidWorks, LabVIEW, Proteus, Fusion 360, having a grasp on python, C++ and assembly language, possess proven ability in acquiring research grants, previous appointments with social and educational societies with experience in administration, current affiliations with IEEE and Web of Science, a confident presenter at conferences and teacher in classrooms, able to explain complex information to audiences of all levels.",institutionString:null,institution:{name:"Air University",country:{name:"Pakistan"}}},{id:"75526",title:"Ph.D.",name:"Zihni Onur",middleName:null,surname:"Uygun",slug:"zihni-onur-uygun",fullName:"Zihni Onur Uygun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/75526/images/12_n.jpg",biography:"My undergraduate education and my Master of Science educations at Ege University and at Çanakkale Onsekiz Mart University have given me a firm foundation in Biochemistry, Analytical Chemistry, Biosensors, Bioelectronics, Physical Chemistry and Medicine. After obtaining my degree as a MSc in analytical chemistry, I started working as a research assistant in Ege University Medical Faculty in 2014. In parallel, I enrolled to the MSc program at the Department of Medical Biochemistry at Ege University to gain deeper knowledge on medical and biochemical sciences as well as clinical chemistry in 2014. In my PhD I deeply researched on biosensors and bioelectronics and finished in 2020. Now I have eleven SCI-Expanded Index published papers, 6 international book chapters, referee assignments for different SCIE journals, one international patent pending, several international awards, projects and bursaries. In parallel to my research assistant position at Ege University Medical Faculty, Department of Medical Biochemistry, in April 2016, I also founded a Start-Up Company (Denosens Biotechnology LTD) by the support of The Scientific and Technological Research Council of Turkey. Currently, I am also working as a CEO in Denosens Biotechnology. The main purposes of the company, which carries out R&D as a research center, are to develop new generation biosensors and sensors for both point-of-care diagnostics; such as glucose, lactate, cholesterol and cancer biomarker detections. My specific experimental and instrumental skills are Biochemistry, Biosensor, Analytical Chemistry, Electrochemistry, Mobile phone based point-of-care diagnostic device, POCTs and Patient interface designs, HPLC, Tandem Mass Spectrometry, Spectrophotometry, ELISA.",institutionString:null,institution:{name:"Ege University",country:{name:"Turkey"}}},{id:"267434",title:"Dr.",name:"Rohit",middleName:null,surname:"Raja",slug:"rohit-raja",fullName:"Rohit Raja",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/267434/images/system/267434.jpg",biography:"Dr. Rohit Raja received Ph.D. in Computer Science and Engineering from Dr. CVRAMAN University in 2016. His main research interest includes Face recognition and Identification, Digital Image Processing, Signal Processing, and Networking. Presently he is working as Associate Professor in IT Department, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur (CG), India. He has authored several Journal and Conference Papers. He has good Academics & Research experience in various areas of CSE and IT. He has filed and successfully published 27 Patents. He has received many time invitations to be a Guest at IEEE Conferences. He has published 100 research papers in various International/National Journals (including IEEE, Springer, etc.) and Proceedings of the reputed International/ National Conferences (including Springer and IEEE). He has been nominated to the board of editors/reviewers of many peer-reviewed and refereed Journals (including IEEE, Springer).",institutionString:"Guru Ghasidas Vishwavidyalaya",institution:{name:"Guru Ghasidas Vishwavidyalaya",country:{name:"India"}}},{id:"246502",title:"Dr.",name:"Jaya T.",middleName:"T",surname:"Varkey",slug:"jaya-t.-varkey",fullName:"Jaya T. Varkey",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/246502/images/11160_n.jpg",biography:"Jaya T. Varkey, PhD, graduated with a degree in Chemistry from Cochin University of Science and Technology, Kerala, India. She obtained a PhD in Chemistry from the School of Chemical Sciences, Mahatma Gandhi University, Kerala, India, and completed a post-doctoral fellowship at the University of Minnesota, USA. She is a research guide at Mahatma Gandhi University and Associate Professor in Chemistry, St. Teresa’s College, Kochi, Kerala, India.\nDr. Varkey received a National Young Scientist award from the Indian Science Congress (1995), a UGC Research award (2016–2018), an Indian National Science Academy (INSA) Visiting Scientist award (2018–2019), and a Best Innovative Faculty award from the All India Association for Christian Higher Education (AIACHE) (2019). She Hashas received the Sr. Mary Cecil prize for best research paper three times. She was also awarded a start-up to develop a tea bag water filter. \nDr. Varkey has published two international books and twenty-seven international journal publications. She is an editorial board member for five international journals.",institutionString:"St. Teresa’s College",institution:null},{id:"250668",title:"Dr.",name:"Ali",middleName:null,surname:"Nabipour Chakoli",slug:"ali-nabipour-chakoli",fullName:"Ali Nabipour Chakoli",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/250668/images/system/250668.jpg",biography:"Academic Qualification:\r\n•\tPhD in Materials Physics and Chemistry, From: Sep. 2006, to: Sep. 2010, School of Materials Science and Engineering, Harbin Institute of Technology, Thesis: Structure and Shape Memory Effect of Functionalized MWCNTs/poly (L-lactide-co-ε-caprolactone) Nanocomposites. Supervisor: Prof. Wei Cai,\r\n•\tM.Sc in Applied Physics, From: 1996, to: 1998, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Determination of Boron in Micro alloy Steels with solid state nuclear track detectors by neutron induced auto radiography, Supervisors: Dr. M. Hosseini Ashrafi and Dr. A. Hosseini.\r\n•\tB.Sc. in Applied Physics, From: 1991, to: 1996, Faculty of Physics & Nuclear Science, Amirkabir Uni. of Technology, Tehran, Iran, Thesis: Design of shielding for Am-Be neutron sources for In Vivo neutron activation analysis, Supervisor: Dr. M. Hosseini Ashrafi.\r\n\r\nResearch Experiences:\r\n1.\tNanomaterials, Carbon Nanotubes, Graphene: Synthesis, Functionalization and Characterization,\r\n2.\tMWCNTs/Polymer Composites: Fabrication and Characterization, \r\n3.\tShape Memory Polymers, Biodegradable Polymers, ORC, Collagen,\r\n4.\tMaterials Analysis and Characterizations: TEM, SEM, XPS, FT-IR, Raman, DSC, DMA, TGA, XRD, GPC, Fluoroscopy, \r\n5.\tInteraction of Radiation with Mater, Nuclear Safety and Security, NDT(RT),\r\n6.\tRadiation Detectors, Calibration (SSDL),\r\n7.\tCompleted IAEA e-learning Courses:\r\nNuclear Security (15 Modules),\r\nNuclear Safety:\r\nTSA 2: Regulatory Protection in Occupational Exposure,\r\nTips & Tricks: Radiation Protection in Radiography,\r\nSafety and Quality in Radiotherapy,\r\nCourse on Sealed Radioactive Sources,\r\nCourse on Fundamentals of Environmental Remediation,\r\nCourse on Planning for Environmental Remediation,\r\nKnowledge Management Orientation Course,\r\nFood Irradiation - Technology, Applications and Good Practices,\r\nEmployment:\r\nFrom 2010 to now: Academic staff, Nuclear Science and Technology Research Institute, Kargar Shomali, Tehran, Iran, P.O. Box: 14395-836.\r\nFrom 1997 to 2006: Expert of Materials Analysis and Characterization. Research Center of Agriculture and Medicine. Rajaeeshahr, Karaj, Iran, P. O. Box: 31585-498.",institutionString:"Atomic Energy Organization of Iran",institution:{name:"Atomic Energy Organization of Iran",country:{name:"Iran"}}},{id:"248279",title:"Dr.",name:"Monika",middleName:"Elzbieta",surname:"Machoy",slug:"monika-machoy",fullName:"Monika Machoy",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/248279/images/system/248279.jpeg",biography:"Monika Elżbieta Machoy, MD, graduated with distinction from the Faculty of Medicine and Dentistry at the Pomeranian Medical University in 2009, defended her PhD thesis with summa cum laude in 2016 and is currently employed as a researcher at the Department of Orthodontics of the Pomeranian Medical University. She expanded her professional knowledge during a one-year scholarship program at the Ernst Moritz Arndt University in Greifswald, Germany and during a three-year internship at the Technical University in Dresden, Germany. She has been a speaker at numerous orthodontic conferences, among others, American Association of Orthodontics, European Orthodontic Symposium and numerous conferences of the Polish Orthodontic Society. She conducts research focusing on the effect of orthodontic treatment on dental and periodontal tissues and the causes of pain in orthodontic patients.",institutionString:"Pomeranian Medical University",institution:{name:"Pomeranian Medical University",country:{name:"Poland"}}},{id:"252743",title:"Prof.",name:"Aswini",middleName:"Kumar",surname:"Kar",slug:"aswini-kar",fullName:"Aswini Kar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/252743/images/10381_n.jpg",biography:"uploaded in cv",institutionString:null,institution:{name:"KIIT University",country:{name:"India"}}},{id:"204256",title:"Dr.",name:"Anil",middleName:"Kumar",surname:"Kumar Sahu",slug:"anil-kumar-sahu",fullName:"Anil Kumar Sahu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204256/images/14201_n.jpg",biography:"I have nearly 11 years of research and teaching experience. I have done my master degree from University Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh India. I have published 16 review and research articles in international and national journals and published 4 chapters in IntechOpen, the world’s leading publisher of Open access books. I have presented many papers at national and international conferences. I have received research award from Indian Drug Manufacturers Association in year 2015. My research interest extends from novel lymphatic drug delivery systems, oral delivery system for herbal bioactive to formulation optimization.",institutionString:null,institution:{name:"Chhattisgarh Swami Vivekanand Technical University",country:{name:"India"}}},{id:"253468",title:"Dr.",name:"Mariusz",middleName:null,surname:"Marzec",slug:"mariusz-marzec",fullName:"Mariusz Marzec",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/253468/images/system/253468.png",biography:"An assistant professor at Department of Biomedical Computer Systems, at Institute of Computer Science, Silesian University in Katowice. Scientific interests: computer analysis and processing of images, biomedical images, databases and programming languages. He is an author and co-author of scientific publications covering analysis and processing of biomedical images and development of database systems.",institutionString:"University of Silesia",institution:null},{id:"212432",title:"Prof.",name:"Hadi",middleName:null,surname:"Mohammadi",slug:"hadi-mohammadi",fullName:"Hadi Mohammadi",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/212432/images/system/212432.jpeg",biography:"Dr. Hadi Mohammadi is a biomedical engineer with hands-on experience in the design and development of many engineering structures and medical devices through various projects that he has been involved in over the past twenty years. Dr. Mohammadi received his BSc. and MSc. degrees in Mechanical Engineering from Sharif University of Technology, Tehran, Iran, and his PhD. degree in Biomedical Engineering (biomaterials) from the University of Western Ontario. He was a postdoctoral trainee for almost four years at University of Calgary and Harvard Medical School. He is an industry innovator having created the technology to produce lifelike synthetic platforms that can be used for the simulation of almost all cardiovascular reconstructive surgeries. He’s been heavily involved in the design and development of cardiovascular devices and technology for the past 10 years. He is currently an Assistant Professor with the University of British Colombia, Canada.",institutionString:"University of British Columbia",institution:{name:"University of British Columbia",country:{name:"Canada"}}},{id:"254463",title:"Prof.",name:"Haisheng",middleName:null,surname:"Yang",slug:"haisheng-yang",fullName:"Haisheng Yang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/254463/images/system/254463.jpeg",biography:"Haisheng Yang, Ph.D., Professor and Director of the Department of Biomedical Engineering, College of Life Science and Bioengineering, Beijing University of Technology. He received his Ph.D. degree in Mechanics/Biomechanics from Harbin Institute of Technology (jointly with University of California, Berkeley). Afterwards, he worked as a Postdoctoral Research Associate in the Purdue Musculoskeletal Biology and Mechanics Lab at the Department of Basic Medical Sciences, Purdue University, USA. He also conducted research in the Research Centre of Shriners Hospitals for Children-Canada at McGill University, Canada. Dr. Yang has over 10 years research experience in orthopaedic biomechanics and mechanobiology of bone adaptation and regeneration. He earned an award from Beijing Overseas Talents Aggregation program in 2017 and serves as Beijing Distinguished Professor.",institutionString:null,institution:{name:"Beijing University of Technology",country:{name:"China"}}},{id:"89721",title:"Dr.",name:"Mehmet",middleName:"Cuneyt",surname:"Ozmen",slug:"mehmet-ozmen",fullName:"Mehmet Ozmen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/89721/images/7289_n.jpg",biography:null,institutionString:null,institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"243698",title:"M.D.",name:"Xiaogang",middleName:null,surname:"Wang",slug:"xiaogang-wang",fullName:"Xiaogang Wang",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/243698/images/system/243698.png",biography:"Dr. Xiaogang Wang, a faculty member of Shanxi Eye Hospital specializing in the treatment of cataract and retinal disease and a tutor for postgraduate students of Shanxi Medical University, worked in the COOL Lab as an international visiting scholar under the supervision of Dr. David Huang and Yali Jia from October 2012 through November 2013. Dr. Wang earned an MD from Shanxi Medical University and a Ph.D. from Shanghai Jiao Tong University. Dr. Wang was awarded two research project grants focused on multimodal optical coherence tomography imaging and deep learning in cataract and retinal disease, from the National Natural Science Foundation of China. He has published around 30 peer-reviewed journal papers and four book chapters and co-edited one book.",institutionString:"Shanxi Eye Hospital",institution:{name:"Shanxi Eye Hospital",country:{name:"China"}}},{id:"242893",title:"Ph.D. Student",name:"Joaquim",middleName:null,surname:"De Moura",slug:"joaquim-de-moura",fullName:"Joaquim De Moura",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/242893/images/7133_n.jpg",biography:"Joaquim de Moura received his degree in Computer Engineering in 2014 from the University of A Coruña (Spain). In 2016, he received his M.Sc degree in Computer Engineering from the same university. He is currently pursuing his Ph.D degree in Computer Science in a collaborative project between ophthalmology centers in Galicia and the University of A Coruña. His research interests include computer vision, machine learning algorithms and analysis and medical imaging processing of various kinds.",institutionString:null,institution:{name:"University of A Coruña",country:{name:"Spain"}}},{id:"294334",title:"B.Sc.",name:"Marc",middleName:null,surname:"Bruggeman",slug:"marc-bruggeman",fullName:"Marc Bruggeman",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/294334/images/8242_n.jpg",biography:"Chemical engineer graduate, with a passion for material science and specific interest in polymers - their near infinite applications intrigue me. \n\nI plan to continue my scientific career in the field of polymeric biomaterials as I am fascinated by intelligent, bioactive and biomimetic materials for use in both consumer and medical applications.",institutionString:null,institution:null},{id:"255757",title:"Dr.",name:"Igor",middleName:"Victorovich",surname:"Lakhno",slug:"igor-lakhno",fullName:"Igor Lakhno",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255757/images/system/255757.jpg",biography:"Igor Victorovich Lakhno was born in 1971 in Kharkiv (Ukraine). \nMD – 1994, Kharkiv National Medical Univesity.\nOb&Gyn; – 1997, master courses in Kharkiv Medical Academy of Postgraduate Education.\nPh.D. – 1999, Kharkiv National Medical Univesity.\nDSC – 2019, PL Shupik National Academy of Postgraduate Education \nProfessor – 2021, Department of Obstetrics and Gynecology of VN Karazin Kharkiv National University\nHead of Department – 2021, Department of Perinatology, Obstetrics and gynecology of Kharkiv Medical Academy of Postgraduate Education\nIgor Lakhno has been graduated from international training courses on reproductive medicine and family planning held at Debrecen University (Hungary) in 1997. Since 1998 Lakhno Igor has worked as an associate professor in the department of obstetrics and gynecology of VN Karazin National University and an associate professor of the perinatology, obstetrics, and gynecology department of Kharkiv Medical Academy of Postgraduate Education. Since June 2019 he’s been a professor in the department of obstetrics and gynecology of VN Karazin National University and a professor of the perinatology, obstetrics, and gynecology department. He’s affiliated with Kharkiv Medical Academy of Postgraduate Education as a Head of Department from November 2021. Igor Lakhno has participated in several international projects on fetal non-invasive electrocardiography (with Dr. J. A. Behar (Technion), Prof. D. Hoyer (Jena University), and José Alejandro Díaz Méndez (National Institute of Astrophysics, Optics, and Electronics, Mexico). He’s an author of about 200 printed works and there are 31 of them in Scopus or Web of Science databases. Igor Lakhno is a member of the Editorial Board of Reproductive Health of Woman, Emergency Medicine, and Technology Transfer Innovative Solutions in Medicine (Estonia). He is a medical Editor of “Z turbotoyu pro zhinku”. Igor Lakhno is a reviewer of the Journal of Obstetrics and Gynaecology (Taylor and Francis), British Journal of Obstetrics and Gynecology (Wiley), Informatics in Medicine Unlocked (Elsevier), The Journal of Obstetrics and Gynecology Research (Wiley), Endocrine, Metabolic & Immune Disorders-Drug Targets (Bentham Open), The Open Biomedical Engineering Journal (Bentham Open), etc. He’s defended a dissertation for a DSc degree “Pre-eclampsia: prediction, prevention, and treatment”. Three years ago Igor Lakhno has participated in a training course on innovative technologies in medical education at Lublin Medical University (Poland). Lakhno Igor has participated as a speaker in several international conferences and congresses (International Conference on Biological Oscillations April 10th-14th 2016, Lancaster, UK, The 9th conference of the European Study Group on Cardiovascular Oscillations). His main scientific interests: are obstetrics, women’s health, fetal medicine, and cardiovascular medicine. \nIgor Lakhno is a consultant at Kharkiv municipal perinatal center. He’s graduated from training courses on endoscopy in gynecology. He has 28 years of practical experience in the field.",institutionString:null,institution:null},{id:"244950",title:"Dr.",name:"Salvatore",middleName:null,surname:"Di Lauro",slug:"salvatore-di-lauro",fullName:"Salvatore Di Lauro",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0030O00002bSF1HQAW/ProfilePicture%202021-12-20%2014%3A54%3A14.482",biography:"Name:\n\tSALVATORE DI LAURO\nAddress:\n\tHospital Clínico Universitario Valladolid\nAvda Ramón y Cajal 3\n47005, Valladolid\nSpain\nPhone number: \nFax\nE-mail:\n\t+34 983420000 ext 292\n+34 983420084\nsadilauro@live.it\nDate and place of Birth:\nID Number\nMedical Licence \nLanguages\t09-05-1985. Villaricca (Italy)\n\nY1281863H\n474707061\nItalian (native language)\nSpanish (read, written, spoken)\nEnglish (read, written, spoken)\nPortuguese (read, spoken)\nFrench (read)\n\t\t\nCurrent position (title and company)\tDate (Year)\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. Private practise.\t2017-today\n\n2019-today\n\t\n\t\nEducation (High school, university and postgraduate training > 3 months)\tDate (Year)\nDegree in Medicine and Surgery. University of Neaples 'Federico II”\nResident in Opthalmology. Hospital Clinico Universitario Valladolid\nMaster in Vitreo-Retina. IOBA. University of Valladolid\nFellow of the European Board of Ophthalmology. Paris\nMaster in Research in Ophthalmology. University of Valladolid\t2003-2009\n2012-2016\n2016-2017\n2016\n2012-2013\n\t\nEmployments (company and positions)\tDate (Year)\nResident in Ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl.\nFellow in Vitreo-Retina. IOBA. University of Valladolid\nVitreo-Retinal consultant in ophthalmology. Hospital Clinico Universitario Valladolid. Sacyl. National Health System.\nVitreo-Retinal consultant in ophthalmology. Instituto Oftalmologico Recoletas. Red Hospitalaria Recoletas. \n\t2012-2016\n2016-2017\n2017-today\n\n2019-Today\n\n\n\t\nClinical Research Experience (tasks and role)\tDate (Year)\nAssociated investigator\n\n' FIS PI20/00740: DESARROLLO DE UNA CALCULADORA DE RIESGO DE\nAPARICION DE RETINOPATIA DIABETICA BASADA EN TECNICAS DE IMAGEN MULTIMODAL EN PACIENTES DIABETICOS TIPO 1. Grant by: Ministerio de Ciencia e Innovacion \n\n' (BIO/VA23/14) Estudio clínico multicéntrico y prospectivo para validar dos\nbiomarcadores ubicados en los genes p53 y MDM2 en la predicción de los resultados funcionales de la cirugía del desprendimiento de retina regmatógeno. Grant by: Gerencia Regional de Salud de la Junta de Castilla y León.\n' Estudio multicéntrico, aleatorizado, con enmascaramiento doble, en 2 grupos\nparalelos y de 52 semanas de duración para comparar la eficacia, seguridad e inmunogenicidad de SOK583A1 respecto a Eylea® en pacientes con degeneración macular neovascular asociada a la edad' (CSOK583A12301; N.EUDRA: 2019-004838-41; FASE III). Grant by Hexal AG\n\n' Estudio de fase III, aleatorizado, doble ciego, con grupos paralelos, multicéntrico para comparar la eficacia y la seguridad de QL1205 frente a Lucentis® en pacientes con degeneración macular neovascular asociada a la edad. (EUDRACT: 2018-004486-13). Grant by Qilu Pharmaceutical Co\n\n' Estudio NEUTON: Ensayo clinico en fase IV para evaluar la eficacia de aflibercept en pacientes Naive con Edema MacUlar secundario a Oclusion de Vena CenTral de la Retina (OVCR) en regimen de tratamientO iNdividualizado Treat and Extend (TAE)”, (2014-000975-21). Grant by Fundacion Retinaplus\n\n' Evaluación de la seguridad y bioactividad de anillos de tensión capsular en conejo. Proyecto Procusens. Grant by AJL, S.A.\n\n'Estudio epidemiológico, prospectivo, multicéntrico y abierto\\npara valorar la frecuencia de la conjuntivitis adenovírica diagnosticada mediante el test AdenoPlus®\\nTest en pacientes enfermos de conjuntivitis aguda”\\n. National, multicenter study. Grant by: NICOX.\n\nEuropean multicentric trial: 'Evaluation of clinical outcomes following the use of Systane Hydration in patients with dry eye”. Study Phase 4. Grant by: Alcon Labs'\n\nVLPs Injection and Activation in a Rabbit Model of Uveal Melanoma. Grant by Aura Bioscience\n\nUpdating and characterization of a rabbit model of uveal melanoma. Grant by Aura Bioscience\n\nEnsayo clínico en fase IV para evaluar las variantes genéticas de la vía del VEGF como biomarcadores de eficacia del tratamiento con aflibercept en pacientes con degeneración macular asociada a la edad (DMAE) neovascular. Estudio BIOIMAGE. IMO-AFLI-2013-01\n\nEstudio In-Eye:Ensayo clínico en fase IV, abierto, aleatorizado, de 2 brazos,\nmulticçentrico y de 12 meses de duración, para evaluar la eficacia y seguridad de un régimen de PRN flexible individualizado de 'esperar y extender' versus un régimen PRN según criterios de estabilización mediante evaluaciones mensuales de inyecciones intravítreas de ranibizumab 0,5 mg en pacientes naive con neovascularización coriodea secunaria a la degeneración macular relacionada con la edad. CP: CRFB002AES03T\n\nTREND: Estudio Fase IIIb multicéntrico, randomizado, de 12 meses de\nseguimiento con evaluador de la agudeza visual enmascarado, para evaluar la eficacia y la seguridad de ranibizumab 0.5mg en un régimen de tratar y extender comparado con un régimen mensual, en pacientes con degeneración macular neovascular asociada a la edad. CP: CRFB002A2411 Código Eudra CT:\n2013-002626-23\n\n\n\nPublications\t\n\n2021\n\n\n\n\n2015\n\n\n\n\n2021\n\n\n\n\n\n2021\n\n\n\n\n2015\n\n\n\n\n2015\n\n\n2014\n\n\n\n\n2015-16\n\n\n\n2015\n\n\n2014\n\n\n2014\n\n\n\n\n2014\n\n\n\n\n\n\n\n2014\n\nJose Carlos Pastor; Jimena Rojas; Salvador Pastor-Idoate; Salvatore Di Lauro; Lucia Gonzalez-Buendia; Santiago Delgado-Tirado. Proliferative vitreoretinopathy: A new concept of disease pathogenesis and practical\nconsequences. Progress in Retinal and Eye Research. 51, pp. 125 - 155. 03/2016. DOI: 10.1016/j.preteyeres.2015.07.005\n\n\nLabrador-Velandia S; Alonso-Alonso ML; Di Lauro S; García-Gutierrez MT; Srivastava GK; Pastor JC; Fernandez-Bueno I. Mesenchymal stem cells provide paracrine neuroprotective resources that delay degeneration of co-cultured organotypic neuroretinal cultures.Experimental Eye Research. 185, 17/05/2019. DOI: 10.1016/j.exer.2019.05.011\n\nSalvatore Di Lauro; Maria Teresa Garcia Gutierrez; Ivan Fernandez Bueno. Quantification of pigment epithelium-derived factor (PEDF) in an ex vivo coculture of retinal pigment epithelium cells and neuroretina.\nJournal of Allbiosolution. 2019. ISSN 2605-3535\n\nSonia Labrador Velandia; Salvatore Di Lauro; Alonso-Alonso ML; Tabera Bartolomé S; Srivastava GK; Pastor JC; Fernandez-Bueno I. Biocompatibility of intravitreal injection of human mesenchymal stem cells in immunocompetent rabbits. Graefe's archive for clinical and experimental ophthalmology. 256 - 1, pp. 125 - 134. 01/2018. DOI: 10.1007/s00417-017-3842-3\n\n\nSalvatore Di Lauro, David Rodriguez-Crespo, Manuel J Gayoso, Maria T Garcia-Gutierrez, J Carlos Pastor, Girish K Srivastava, Ivan Fernandez-Bueno. A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells. Molecular Vision. 2016 - 22, pp. 243 - 253. 01/2016.\n\nSalvatore Di Lauro. Classifications for Proliferative Vitreoretinopathy ({PVR}): An Analysis of Their Use in Publications over the Last 15 Years. Journal of Ophthalmology. 2016, pp. 1 - 6. 01/2016. DOI: 10.1155/2016/7807596\n\nSalvatore Di Lauro; Rosa Maria Coco; Rosa Maria Sanabria; Enrique Rodriguez de la Rua; Jose Carlos Pastor. Loss of Visual Acuity after Successful Surgery for Macula-On Rhegmatogenous Retinal Detachment in a Prospective Multicentre Study. Journal of Ophthalmology. 2015:821864, 2015. DOI: 10.1155/2015/821864\n\nIvan Fernandez-Bueno; Salvatore Di Lauro; Ivan Alvarez; Jose Carlos Lopez; Maria Teresa Garcia-Gutierrez; Itziar Fernandez; Eva Larra; Jose Carlos Pastor. Safety and Biocompatibility of a New High-Density Polyethylene-Based\nSpherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits. Journal of Ophthalmology. 2015:904096, 2015. DOI: 10.1155/2015/904096\n\nPastor JC; Pastor-Idoate S; Rodríguez-Hernandez I; Rojas J; Fernandez I; Gonzalez-Buendia L; Di Lauro S; Gonzalez-Sarmiento R. Genetics of PVR and RD. Ophthalmologica. 232 - Suppl 1, pp. 28 - 29. 2014\n\nRodriguez-Crespo D; Di Lauro S; Singh AK; Garcia-Gutierrez MT; Garrosa M; Pastor JC; Fernandez-Bueno I; Srivastava GK. Triple-layered mixed co-culture model of RPE cells with neuroretina for evaluating the neuroprotective effects of adipose-MSCs. Cell Tissue Res. 358 - 3, pp. 705 - 716. 2014.\nDOI: 10.1007/s00441-014-1987-5\n\nCarlo De Werra; Salvatore Condurro; Salvatore Tramontano; Mario Perone; Ivana Donzelli; Salvatore Di Lauro; Massimo Di Giuseppe; Rosa Di Micco; Annalisa Pascariello; Antonio Pastore; Giorgio Diamantis; Giuseppe Galloro. Hydatid disease of the liver: thirty years of surgical experience.Chirurgia italiana. 59 - 5, pp. 611 - 636.\n(Italia): 2007. ISSN 0009-4773\n\nChapters in books\n\t\n' Salvador Pastor Idoate; Salvatore Di Lauro; Jose Carlos Pastor Jimeno. PVR: Pathogenesis, Histopathology and Classification. Proliferative Vitreoretinopathy with Small Gauge Vitrectomy. Springer, 2018. ISBN 978-3-319-78445-8\nDOI: 10.1007/978-3-319-78446-5_2. \n\n' Salvatore Di Lauro; Maria Isabel Lopez Galvez. Quistes vítreos en una mujer joven. Problemas diagnósticos en patología retinocoroidea. Sociedad Española de Retina-Vitreo. 2018.\n\n' Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor Jimeno. iOCT in PVR management. OCT Applications in Opthalmology. pp. 1 - 8. INTECH, 2018. DOI: 10.5772/intechopen.78774.\n\n' Rosa Coco Martin; Salvatore Di Lauro; Salvador Pastor Idoate; Jose Carlos Pastor. amponadores, manipuladores y tinciones en la cirugía del traumatismo ocular.Trauma Ocular. Ponencia de la SEO 2018..\n\n' LOPEZ GALVEZ; DI LAURO; CRESPO. OCT angiografia y complicaciones retinianas de la diabetes. PONENCIA SEO 2021, CAPITULO 20. (España): 2021.\n\n' Múltiples desprendimientos neurosensoriales bilaterales en paciente joven. Enfermedades Degenerativas De Retina Y Coroides. SERV 04/2016. \n' González-Buendía L; Di Lauro S; Pastor-Idoate S; Pastor Jimeno JC. Vitreorretinopatía proliferante (VRP) e inflamación: LA INFLAMACIÓN in «INMUNOMODULADORES Y ANTIINFLAMATORIOS: MÁS ALLÁ DE LOS CORTICOIDES. 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We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics can include but are not limited to: Biotechnology such as biotechnological products and process engineering; Biotechnologically relevant enzymes and proteins; Bioenergy and biofuels; Applied genetics and molecular biotechnology; Genomics, transcriptomics, proteomics; Applied microbial and cell physiology; Environmental biotechnology; Methods and protocols. Moreover, topics in biosensor technology, like sensors that incorporate enzymes, antibodies, nucleic acids, whole cells, tissues and organelles, and other biological or biologically inspired components will be considered, and topics exploring transducers, including those based on electrochemical and optical piezoelectric, thermal, magnetic, and micromechanical elements. Chapters exploring biomaterial approaches such as polymer synthesis and characterization, drug and gene vector design, biocompatibility, immunology and toxicology, and self-assembly at the nanoscale, are welcome. Finally, the tissue engineering subcategory will support topics such as the fundamentals of stem cells and progenitor cells and their proliferation, differentiation, bioreactors for three-dimensional culture and studies of phenotypic changes, stem and progenitor cells, both short and long term, ex vivo and in vivo implantation both in preclinical models and also in clinical trials.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/9.jpg",keywords:"Biotechnology, Biosensors, Biomaterials, Tissue Engineering"}],annualVolumeBook:{},thematicCollection:[],selectedSeries:null,selectedSubseries:null},seriesLanding:{item:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983",scope:"Biochemistry, the study of chemical transformations occurring within living organisms, impacts all areas of life sciences, from molecular crystallography and genetics to ecology, medicine, and population biology. Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. This Biochemistry Series will address the current research on biomolecules and the emerging trends with great promise.",coverUrl:"https://cdn.intechopen.com/series/covers/11.jpg",latestPublicationDate:"June 24th, 2022",hasOnlineFirst:!0,numberOfOpenTopics:4,numberOfPublishedChapters:314,numberOfPublishedBooks:31,editor:{id:"31610",title:"Dr.",name:"Miroslav",middleName:null,surname:"Blumenberg",fullName:"Miroslav Blumenberg",profilePictureURL:"https://mts.intechopen.com/storage/users/31610/images/system/31610.jpg",biography:"Miroslav Blumenberg, Ph.D., was born in Subotica and received his BSc in Belgrade, Yugoslavia. He completed his Ph.D. at MIT in Organic Chemistry; he followed up his Ph.D. with two postdoctoral study periods at Stanford University. Since 1983, he has been a faculty member of the RO Perelman Department of Dermatology, NYU School of Medicine, where he is codirector of a training grant in cutaneous biology. Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. He has published more than 100 peer-reviewed research articles and graduated numerous Ph.D. and postdoctoral students.",institutionString:null,institution:{name:"New York University Langone Medical Center",institutionURL:null,country:{name:"United States of America"}}},subseries:[{id:"14",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",annualVolume:11410,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},{id:"15",title:"Chemical Biology",keywords:"Phenolic Compounds, Essential Oils, Modification of Biomolecules, Glycobiology, Combinatorial Chemistry, Therapeutic peptides, Enzyme Inhibitors",scope:"Chemical biology spans the fields of chemistry and biology involving the application of biological and chemical molecules and techniques. In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. This topic will closely deal with all emerging trends in this discipline.",annualVolume:11411,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/15.jpg",editor:{id:"441442",title:"Dr.",name:"Şükrü",middleName:null,surname:"Beydemir",fullName:"Şükrü Beydemir",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y00003GsUoIQAV/Profile_Picture_1634557147521",institutionString:null,institution:{name:"Anadolu University",institutionURL:null,country:{name:"Turkey"}}},editorTwo:{id:"13652",title:"Prof.",name:"Deniz",middleName:null,surname:"Ekinci",fullName:"Deniz Ekinci",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002aYLT1QAO/Profile_Picture_1634557223079",institutionString:null,institution:{name:"Ondokuz Mayıs University",institutionURL:null,country:{name:"Turkey"}}},editorThree:null,editorialBoard:[{id:"241413",title:"Dr.",name:"Azhar",middleName:null,surname:"Rasul",fullName:"Azhar Rasul",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRT1oQAG/Profile_Picture_1635251978933",institutionString:null,institution:{name:"Government College University, Faisalabad",institutionURL:null,country:{name:"Pakistan"}}},{id:"178316",title:"Ph.D.",name:"Sergey",middleName:null,surname:"Sedykh",fullName:"Sergey Sedykh",profilePictureURL:"https://mts.intechopen.com/storage/users/178316/images/system/178316.jfif",institutionString:null,institution:{name:"Novosibirsk State University",institutionURL:null,country:{name:"Russia"}}}]},{id:"17",title:"Metabolism",keywords:"Biomolecules Metabolism, Energy Metabolism, Metabolic Pathways, Key Metabolic Enzymes, Metabolic Adaptation",scope:"Metabolism is frequently defined in biochemistry textbooks as the overall process that allows living systems to acquire and use the free energy they need for their vital functions or the chemical processes that occur within a living organism to maintain life. Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. Thus all studies on metabolism will be considered for publication.",annualVolume:11413,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/17.jpg",editor:{id:"138626",title:"Dr.",name:"Yannis",middleName:null,surname:"Karamanos",fullName:"Yannis Karamanos",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002g6Jv2QAE/Profile_Picture_1629356660984",institutionString:null,institution:{name:"Artois University",institutionURL:null,country:{name:"France"}}},editorTwo:null,editorThree:null,editorialBoard:[{id:"243049",title:"Dr.",name:"Anca",middleName:null,surname:"Pantea Stoian",fullName:"Anca Pantea Stoian",profilePictureURL:"https://mts.intechopen.com/storage/users/243049/images/system/243049.jpg",institutionString:null,institution:{name:"Carol Davila University of Medicine and Pharmacy",institutionURL:null,country:{name:"Romania"}}},{id:"203824",title:"Dr.",name:"Attilio",middleName:null,surname:"Rigotti",fullName:"Attilio Rigotti",profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",institutionString:null,institution:{name:"Pontifical Catholic University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"300470",title:"Dr.",name:"Yanfei (Jacob)",middleName:null,surname:"Qi",fullName:"Yanfei (Jacob) Qi",profilePictureURL:"https://mts.intechopen.com/storage/users/300470/images/system/300470.jpg",institutionString:null,institution:{name:"Centenary Institute of Cancer Medicine and Cell Biology",institutionURL:null,country:{name:"Australia"}}}]},{id:"18",title:"Proteomics",keywords:"Mono- and Two-Dimensional Gel Electrophoresis (1-and 2-DE), Liquid Chromatography (LC), Mass Spectrometry/Tandem Mass Spectrometry (MS; MS/MS), Proteins",scope:"With the recognition that the human genome cannot provide answers to the etiology of a disorder, changes in the proteins expressed by a genome became a focus in research. Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. The Proteomics topic aims to attract contributions on all aspects of MS-based proteomics that, by pushing the boundaries of MS capabilities, may address biological problems that have not been resolved yet.",annualVolume:11414,isOpenForSubmission:!0,coverUrl:"https://cdn.intechopen.com/series_topics/covers/18.jpg",editor:{id:"200689",title:"Prof.",name:"Paolo",middleName:null,surname:"Iadarola",fullName:"Paolo Iadarola",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSCl8QAG/Profile_Picture_1623568118342",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorTwo:{id:"201414",title:"Dr.",name:"Simona",middleName:null,surname:"Viglio",fullName:"Simona Viglio",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRKDHQA4/Profile_Picture_1630402531487",institutionString:null,institution:{name:"University of Pavia",institutionURL:null,country:{name:"Italy"}}},editorThree:null,editorialBoard:[{id:"72288",title:"Dr.",name:"Arli Aditya",middleName:null,surname:"Parikesit",fullName:"Arli Aditya Parikesit",profilePictureURL:"https://mts.intechopen.com/storage/users/72288/images/system/72288.jpg",institutionString:null,institution:{name:"Indonesia International Institute for Life Sciences",institutionURL:null,country:{name:"Indonesia"}}},{id:"40928",title:"Dr.",name:"Cesar",middleName:null,surname:"Lopez-Camarillo",fullName:"Cesar Lopez-Camarillo",profilePictureURL:"https://mts.intechopen.com/storage/users/40928/images/3884_n.png",institutionString:null,institution:{name:"Universidad Autónoma de la Ciudad de México",institutionURL:null,country:{name:"Mexico"}}},{id:"81926",title:"Dr.",name:"Shymaa",middleName:null,surname:"Enany",fullName:"Shymaa Enany",profilePictureURL:"https://mts.intechopen.com/storage/users/81926/images/system/81926.png",institutionString:"Suez Canal University",institution:{name:"Suez Canal University",institutionURL:null,country:{name:"Egypt"}}}]}]}},libraryRecommendation:{success:null,errors:{},institutions:[]},route:{name:"chapter.detail",path:"/chapters/13538",hash:"",query:{},params:{id:"13538"},fullPath:"/chapters/13538",meta:{},from:{name:null,path:"/",hash:"",query:{},params:{},fullPath:"/",meta:{}}}},function(){var e;(e=document.currentScript||document.scripts[document.scripts.length-1]).parentNode.removeChild(e)}()