Market values and growth rates for different related technologies: Printed electronics, functional printing, inkjet printing, functional inks, and smart products.
\r\n\tWe are living in a particularly challenging historical moment. People have learned that no matter how much they control their lives, their environment, and their relationships, everything can be changed instantly, at the fancy of a virus that does not respect age, nationality, ancestry, intelligence, or skills. People learned that the limitless power of science and technology was purely illusory, in the face of an absolute and overwhelming force of nature that was almost no longer recognized. After all, the balance of forces between Nature and science and technology was inevitably shaken and the certainties with which people built their lives were jeopardized by an unpredictable and constantly changing reality. Uncertainty is one of the biggest challenges we face today. Never, as today, people management can make such a difference in their future, both personally and professionally.
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Inkjet printing (IJP) is a widespread technology used in personal and industrial printers. Recently, it has started to gain traction as a new promising technology for the direct patterning of solution-based functional materials. IJP relies on a non-impact dot-matrix printing technology in which droplets of ink are flown from small openings, called nozzles, directly to a designated position on a media to produce an image. The printed patterns are digitally defined and directly transferred to the printer. The nozzles or the substrate holder move accordingly to a pre-programmed pattern, which allows the printing of virtually any pattern [1, 2].
IJP technique is particularly interesting for applications in the printed electronics field as it allows for rapid prototyping and is compatible with various substrates, and conductive, semiconductive, and dielectric inks that can be cured at low temperatures. As a result, several application examples of this technology have already been advanced in the literature [3, 4, 5, 6, 7, 8, 9]. IJP methods are widely employed in the manufacture of sensors and actuators, and many electrically conductive inks are already commercially available and optimized according to specific characteristics that make them suitable for IJP [10]. Since IJP relies on the use of computer software, it allows for rapid prototyping and freedom of design combined with tunable resolution [11]. Throughout the literature, some examples include IJP temperature sensors [12, 13, 14], humidity sensors [15, 16, 17], and pressure and strain sensors, that can be capacitive [18, 19], piezoresistive [20, 21], and piezoelectric [22, 23, 24]. These sensors and actuators can be integrated into novel smart products.
According to recent technical reports, printed electronics (PE), particularly IJP and its enabling technologies (functional printing and inks) show an increased market interest and growth. Table 1 presents the market expectations related to these technologies.
Printed electronics [25] | Functional printing [26] | Inkjet Printing [27] | Functional inks [28] | |
---|---|---|---|---|
2020 market value, B$ | 7.9 | 8.9 | 40.8 | 0.87 |
2027 market value, B$ | 22.7 | 23.9 | 49.2 | 1.3 |
CAGR, % | 21.5 | 15.1 | 3.11 | 5.3 |
Typical applications | Batteries, sensors, sign boards, labels, PCB, touch panels, LED panels, solar cells | Sensors, displays, batteries, RFID tags, lighting, photovoltaic, electronic components | Flexible OLED displays, wearables, photovoltaic, sensors, PCB | PCB, MEMS, security printing, smart textiles, displays, smart packaging, RFID tags, photovoltaics, biochips |
Market values and growth rates for different related technologies: Printed electronics, functional printing, inkjet printing, functional inks, and smart products.
PE market will continue to expand over the coming years, with a strong emphasis on energy harvesting and storage for electronic cars, gadgets, equipment, components, and other industries that rely on PE to reduce total energy usage. The PE market will be driven by low production costs, environmentally friendly technologies, a diverse choice of substrates, and a rising demand for flexible electronics applications. PE has allowed printing of electronic and electrical components on lightweight, cost-efficient and flexible materials (like cloth, paper, or polymeric films) in conventional electrical circuits. This PE market will continue to expand mainly driven by [29]: (a) the increasing development of smart and connected devices, as demanded by Internet of Things (IoT); (b) the rising demand for energy-effective, thin, and flexible consumer electronics; (c) the substantial costs reduction provided by PE; and (d) the importance of environmentally sustainable technologies.
The increased demand for low-cost and high-volume production of electronics will boost the functional printing market. This is supported by the increased availability of a wide range of substrates, high-throughput manufacturing technologies (e.g., R2R for large-area electronics processing), and a reduced environmental impact (e.g., thin and flexible electronics) [30]. This will be fostered by the development of new products/applications, the introduction of added functionalities into multiple products, and the emergent widespread of digital manufacturing techniques.
After a huge pace of growth, the IJP market is becoming mature, and high-speed inkjet printing devices with enhanced quality and higher productivity are already available. Notwithstanding, the initial costs of equipment are still rather high. Major applications of IJP have been related to graphic communication and packaging labeling, but functional substrates and objects driven by PE and functional printing applications are fostering IJP market. Principal drivers for the adoption of IJP technologies are OLED displays, products/processes digitalization, IoT, Cyber-physical systems (CPS), and Big Data.
Functional inks can be electrically conductive, resistive, dielectric, semi-conductive, or have other special functions, such as thermal conductivity, electroluminescence, light-diffusing, or piezoelectric. Functional inks are key enablers for PE applications. They must combine their functionality with being flexible, processable at low temperature, adhere to a wide range of substrates, in some cases transparent, and straightforward to manufacture. Novel functional inks include suspensions of organic or inorganic nanomaterials, or particle-free solutions of organic materials, which are inherently stretchable, and suitable for applications in e-textiles and in-mold electronics [31].
Smart products are physical objects equipped with sensors, embedded artificial intelligence, communication ability, and information technology. They bridge the physical and digital worlds, sharing information about themselves, their environment, and their use, being supported by emergent technologies of CPS, IoT, and artificial intelligence (AI). Furthermore, smart products are now connected and able of forming product eco-systems; they interact with the user, adding a social layer to these eco-systems. This allows a paradigm shift in the business world: from selling products to offering services, to the “servitization” of products (Figure 1). This transformation towards novel smart products is enabled by the development of emergent technologies simultaneously in both the physical (hardware) and digital (software) worlds, and their interfaces. This chapter focuses attention on product manufacturing (hardware) technologies for smart products, namely those based on PE and functional printing, and more specifically on inkjet printing of functional inks.
System of smart products.
IPJ is an additive manufacturing technique that encompasses an ink reservoir that is connected to a print head device and responsible for jetting ink droplets over a pre-determined substrate. IJP allows for high-resolution 2D patterning, ink economization, and non-contact deposition via a micrometer-sized inkjet nozzle head [32, 33]. Inkjet can be divided into two main distinct processes (Figure 2): Continuous inkjet (CIJ) printing and Drop-on-demand (DoD) printing technologies [35]. As the name suggests, in CIJ printing the droplets are continuously generated and deposited when subjected to an electrostatic field, caused by a charging electrode. DoD printing, on the other hand, relies on the selective activation of the print-head through impulses that can be acoustic, electrostatic, thermal, and piezoelectric (the latter two are the most reported cases) [35].
IJP methods: (a) CIJ, and DOD inkjet printing with (b) piezoelectric and (c) thermal head [
The CIJ process is mainly used in industrial printers, mostly for packaging and graphical applications. In this case, the ink droplets are continuously expelled due to the effect of an electric field that actuates the piezoelectric crystal of the printhead. Although this process can be used for PE it is majorly directed at continuously printing large volumes of nonfunctional inks [36]. Concerning DoD inkjet printing, several sub-methods can be identified. The most disseminated ones are piezoelectric and thermal inkjet printing, nonetheless, there are other methods whose popularity is increasing and can also grant high-quality printing of functional inks [36]. Among those, electrohydrodynamic (EHD)-IJP [37, 38, 39], aerosol jet printing [40], drop impact printing [41], and acoustic printing [42], can be highlighted.
In the piezoelectric IJP method, the ink reservoir is coupled with piezoelectric constrictors that load and expel the ink (print head). In this process, the dimensions of the ink droplet can be controlled, so the ink consumption is very low. To avoid clogging the nozzles, the functional inks must be produced taking into account specific properties, such as particle size, ink viscosity, surface tension, and density [35]. The nozzle is designed to be resistant to organic solvents and is therefore compatible with a wide range of solvents for ink formulation [2]. Table 2 summarizes the main characteristics of the inks that are compatible with each one of the inkjet printing methods and sub-methods. Comparing the different printing sub-methods, it is clear that the thermal and the piezoelectric ones are much more limited in terms of suitable ink viscosity range. Nonetheless, they are still currently the most approachable methods in terms of affordability and widespread commercial availability of the equipment.
Printing Method | Sub-method | Particle size (nm) | Viscosity (cP) | Surface Tension (dynes/cm) | Resolution (μm) |
---|---|---|---|---|---|
CIJ | — | <1000 | 1–10 | 25–70 | |
DoD | Thermal | <1000 | 5–30 | 35–70 | 2–100 |
Piezoelectric | <300 | 1–30 | 35–70 | 2–100 | |
EHD | 3–300 | 1–4000 | 35–70 | 0.2–1 | |
Aerosol | 10–30 | 0.5–2500 | 20–70 | 5–20 | |
Acoustic | <100 | 0.5–25,000 | 15–650 | 10–20 | |
Drop impact | <20,000 | 0.5–33 | 32–70 | 40–960 |
Except for the jetting method, the overall process of printing is common to all CIJ and DoD IJP techniques. The printed patterns are digitally generated (CAD software) and can be easily changed, which makes this printing technique an ideal choice for prototyping and design optimization. Figure 3 depicts the main stages in IJP:
Digital pattern—A CAD software (or other graphic software) is used to digitally generate the printed pattern.
Substrate surface preparation—the substrate surface is cleaned with an appropriate cleaning agent; a surface treatment can be selected for better ink adhesion.
Ink preparation—ink can be filtered to remove impurities; ink viscosity can be changed by using an adequate solvent; a surface treatment technique can be applied (e.g., plasma, corona discharge); the ink must be stirred for better particle suspension dispersion.
Inkjet printing—the file is uploaded in the printer software; the reservoir is filled with the ink; the ink can be preheated before printing; the printing parameters are defined, mainly for controlling the printing head (see next section); then, printing takes place.
Post printing—after printing the printed pattern must be sintered/cured (by temperature, photonic, UV light, plasma); a protective layer can be applied (e.g., by lamination, spray coating)
Inkjet printing steps.
The IJP technology for PE applications and its technical-scientific developments have been reviewed over the last decades. Hue P. Le [44], 1999, reported the developments in the various IJP technologies, noting the significant growth rate of inkjet printers market. New ink formulations and new printhead designs were recognized as relevant for new applications. In 2010, the state-of-the-art of IJP of functional materials was reviewed by Raje and Murmu [45]. Improvements in process throughput remained the major challenge. In the same year, Derby reviewed the current understanding of the mechanisms of drop formation and the interactions between drops and the substrate, with a focus on the fabrication of structures for structural or functional materials applications [46]. Two years later, in 2012, Cummins and Desmulliez conducted a review in IJP of conductive materials [47]. IJP process, substrate properties, and types of conductive inks are the various factors that affect the quality of inkjet-printed products and their increasing relevance to the fields of electronics manufacturing, packaging, and assembly. In 2019, Nayak et al. reviewed the IJP of electronic devices, mainly addressing the fluid dynamics of inks and main properties (e.g., viscosity, surface tension, Weber number, Reynolds number, and Ohnesorge number) and their effects on defects appearance (coffee ring formation) [48]. The use of functional inks in sensors, thin-film transistors, and energy storage devices is presented. Ke Yan et al. revised the state-of-the-art related IJP strategies and functional inks for wearable electronic devices (e.g., sensors, displays, transistors, and energy storage devices) [49]. They highlighted the need of having available more intrinsically flexible and stretchable inks for avoiding, cracking, and delamination on highly flexible/stretchable substrates. Also, IJP technology development shall solve nozzle clogging issues for a more stable printing process. Kye-Si Kwon et al. reviewed piezo-driven IJP for PE. Other printing methods for high viscosity ink are also considered and compared (e.g., electrohydrodynamic jet, aerosol jet, and micro-plotter printing) [50]. There is a high demand for high-resolution printing of high viscosity inks for PE. In this case, the functionality of the device is more important than graphism perception, and the development of suitable inks for IJP remains one of the key issues. More recently, Muhammad Ali Shah reviewed the classifications and applications (textile, displays, and wearable devices) of IJP with more attention paid to piezoelectric IJP due to its higher relevance [36]. Various driving-voltage waveforms approaches are compared. Recently published studies on applications of IJP are summarized. Again, high high-viscosity IJP technologies are revised. The performance of IJP shall be improved by the development of new printheads with ink-recirculation and new techniques for printing high viscosity inks.
The use of inks has been around for almost as long as there is human life. It empowered evolution and was responsible for cultural and sociological developments whose footprints can be traced from the Paleolithic to this day [51]. The methods to dispense inks have also evolved with them and the first inkjet-type apparatus was patented in 1858 by William Thomson and Abbe Nollet [52]. The concept of printing functional conducive inks emerged some years later, in the 20th century, and was patented by Albert Hanson [53]. Nonetheless, research in IJP of functional inks exploded only nearly 100 years later, at the turn of the 21stcentury, thanks to the breakthrough development of organic conducting polymers by Heeger, MacDiarmid, and Shirakawa, which rendered them the 2000 Chemistry Nobel Prize [54, 55]. This led to several advancements in the field of PE, including the development of the first high-resolution printed all-polymer transistor circuits [56, 57, 58]. The fact that polymeric inks are more stable, easier to formulate, manipulate, and print was mostly responsible for this paradigm shift [43]. Nonetheless, with the technical developments experienced in this field, metallic-based inks started to be printed shortly after, thanks to the use of stable solvent systems and other additives that allowed to stabilize the metallic particles into homogeneously dispersed formulations with tunable surface tension and viscosity. Thereby, nowadays several base materials can be selected, depending on the final device desired functionality.
Functional inks for inkjet printing can be divided into, conductive, semi-conductive, and dielectric. Conductive inks are usually applied in the development of conductive tracks, vias, and electrodes. They generally rely on the dispersion of metallic nanoparticles, namely Ag [59], Cu [60], and Au [61], on organic or water-based solvents. To aid in the dispersion and grant long-term stability of these inks, surfactants, stabilizers, humectants, and other additive compounds are demanded [32]. To further tune the ink properties conductive nanofillers such as CNT can also be added. Although less conductive than metals, some polymers, metal-oxides, liquid-metal alloys, MXenes, perovskites, quantum-dots, and metal–organic-decomposition inks can also be used in the development of conductive inks. Currently, indium tin oxide (ITO) is still the most used material to produce transparent electrodes for thin-film devices (organic light-emitting diodes, OLED; field-effect transistors, OFET; photovoltaic devices, OPV) [62, 63]. However, the deposition o ITO is usually done by resorting to physical vapor deposition (PVD) which is much more expensive and energy-demanding than printing technologies. Moreover, its over-exploitation is damaging to the environment, and it is only recyclable through energy-consuming processes [64]. MXenes, quantum dots, and perovskites are examples of alternative base materials that can be used to develop inks for inkjet printing transparent electrodes for the above-mentioned applications. As a result, even though they have lower power conversion efficiency, their popularity is increasing [65, 66]. Despite being known for their higher electrical conductivity most inorganic inks are expensive, become brittle after curing, have limited flexibility, and might experience oxidation and loss of performance, if not properly encapsulated. As a result, organic conductive polymers such as poly(3, 4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) [10, 67, 68], poly(3-hexylthiophene-2,5-diyl) (P3HT) [69, 70], and oxidized polyaniline (PANI) [71] are also being used as alternative materials for printing electrodes and conductive tracks. Other highly conductive inks can be developed using carbon allotropes, such as single-walled and multi-walled carbon nanotubes (SWCNT and MWCNT) [72, 73, 74, 75, 76], graphene [77, 78], and fullerenes [79].
Semiconductors have an electrical conductivity that can vary between the conductor and the dielectric. They can be n-type or p-type, depending on the doping atomic impurities added to the structure of the semiconductor. These impurities define the electrical properties, with highly doped semiconductors presenting conductivity values similar to metals. When the semiconducting material is less doped, its conductivity departs further from the conductive range. These semiconductors are crucial for the performance of the final device since their characteristics usually change with environmental physical, or chemical conditions [43, 72]. Less doped inorganic semiconductors include zinc-oxide (ZnO), zinc tin oxide (ZTO), and indium-zinc-oxide (IZO). Another interesting material for the development of semiconductor inkjet inks is the amorphous indium-gallium-zinc-oxide (a-IGZO), as it is processable at low temperatures, being vastly used in thin-film-transistors and solar cells [80]. On the other hand, organic semiconductors can be PEDOT: PSS, rubrene, pentacene, poly(diketopyrrolopyrrole-terthiophene) (PDPP3T), diphenylanthracene (DPA) [43]. PEDOT: PSS and CNT-based composites are vastly used as pressure sensors (piezorresistive materials) [81, 82], and temperature sensors (thermoresistive materials) [83, 84].
Finally, dielectrics exist in the less conductive boundary of the conductivity spectrum. They are used in electrical applications that demand high capacitance and insulation. Some dielectrics inks can be made from metal–organic materials such as aluminum oxide (Al2O3), zirconium oxide (ZrO2), hafnium oxide (HfO2), and yttrium oxide (YO2). Nevertheless, organic dielectric inks can also be formulated from polyvinylpyrrolidone (PVP), Polyvinyl alcohol (PVA), and Polymethyl methacrylate (PMMA), polydimethylsiloxane (PDMS), Polyvinylidene fluoride (PVDF) and its copolymer, polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE). PVDF-based inks are of extreme importance since they are ferroelectric and enable piezoelectric applications. Another inkjet ink is the electrostrictive P(VDF-TrFE-CTFE) terpolymer, which can be used for energy harvesting applications [85, 86, 87]. Table 3 summarizes the different types of printable inks.
Ink | Description | Examples |
---|---|---|
Conductive | Composed of highly conductive materials, mostly metals, metal-based composites, metal oxides, metallic alloys, highly doped conductive organic polymers in solvents, metal-oxide particles suspended in binders or organic-metallic blends | Metallic nanoparticle-based inks; Conductive polymers; Graphene inks; Perovskites; Mxenes; Quantum dots; Metal oxide-based inks; Eutectic liquid metals |
Semi-conductive | Composed of semiconducting organic polyme*rs in solvents, inorganic nanoparticles (Group III-V, II-VI and IV semiconductors and carbon nanotubes) suspended in carrier fluids, or organic–inorganic blends; Also composed of less doped polymers that can be reinforced with carbon nanotubes or wires. | Metal-oxide inks; Semi-conductive polymers; Carbon-based inks |
Dielectric | Organic polymers in solvents, organic polymer thermosets or ceramic-filled organic polymers | Ceramics; Metal–organic materials; Dielectric polymers; Piezoelectric polymers |
Summary of ink types, their description, and some examples.
Both CIJ and DoD printing demand the use of inks with particle size under 1 μm (ideally <300 nm). In the particular case of the piezoelectric DoD method, their viscosity should be in the range of 1-20 cP, and their surface tension between 35 and 70 mN.m−1 [35]. IJP requires no mask, has a low ink waste rate, and typical linewidth resolution of 30-50 μm [88]. DoD has established itself as the main IJP technology, with piezoelectric method being the most widely employed when it comes to IJP printing of functional inks, as it allows less ink consumption [49]. Hence, inks are specifically formulated to meet the requirements of the printing process [49].
To achieve the best possible printing quality, several factors need to be taken into account and studied from an optimization-driven perspective. For instance, the rheological properties of the ink (viscosity, surface tension, and density) interplay with each other and cannot be individually assessed. Similarly, the parameters of the printing process themselves cannot be individually studied. Thus, the printing resolution, printhead speed, printhead height, waveform profile, droplet size, and printhead temperature also influence one another and, as a result, before high-quality printing can be attained, a series of optimization studies need to be conducted for each combination of ink/substrate. Other variables include the pre and post-treatment of the ink, substrate, and printed outputs. The operator experience and the environmental conditions will ultimately also influence the printing process. In Figure 4. the main print quality affecting parameters are summarized in a Fishbone diagram. Since several factors need to be simultaneously studied, a design of experiments approach is frequently performed by researchers aiming to rapidly optimize the process [59, 89, 90, 91].
Potential cause-effect factors influencing printing quality and conductivity.
Even after all parameters are optimized, some issues can still occur during the printing process namely nozzle clogging, printing deficiencies (coffee-ring effect, satellite drops, random electrical interference that causes droplet jetting oddness, missing droplets), loss of ink dispersibility, presence of dirt or dust particles in the ink system or substrate, among other issues [92]. As a result, to use IJP to develop electronic devices in industrial settings in-line quality control methods should be performed as a way of assuring functionality. To prevent the effect of environmental variables, which are often uncontrollable, the printing process should be performed in a controlled clean-room area.
Inks intended for inkjet printing should have linear Newtonian behavior and low viscosity, within a specific range. The drop formation and dynamics of the ink are ruled by three dimensionless numbers, that are related to the ink rheological and physical properties, namely the Reynolds number (
where,
Ohnesorge diagram, evidencing the fundamental characteristics of the printable fluid and the different drop break-up regimes responsible for printing errors, and requirements summary for developing a printable fluid.
Another parameter that demands the previous study when planning inkjet printing is the adhesion between ink and substrate. This may affect the final printing result and additional procedures might be needed to assure compatibility. For ink to adhere well to a substrate, it must present appropriate wettability and adhesive bondability [96], meaning the surface tension of the ink must be lower than the wetting tension of the substrate (surface energy). To test this parameter, the substrate must be completely dry and free of any contaminants to start with. If after cleaning the substrate it still presents low wettability, surface pre-treatments may be needed. Such treatments include surface modification resorting to chemical modification, coating with hydrophilic moieties (such as PVP and PVA solutions) [97, 98], plasma activation [98, 99, 100], mechanical abrasion, or superficial integration of nanoparticles or nanoclays [101], which increase surface roughness. Plasma activation is usually done by resorting to corona discharge plasma treatment and relies on the production of a high voltage electrical discharge that ionizes the molecules of the treated surface, positively changing its polarity (or oxidizing it) [99, 102, 103].
To improve the printability of the ink some actions can be taken. Re-dispersion followed by filtration of the ink before use is effective in removing impurities and potential particle agglomerates that could clog the microscopic nozzles. The presence of trapped air bubbles in the ink is also damaging to the printing process. To prevent trapped bubbles, the ink should be degassed after filtering and left to rest for at least 30 minutes after filling the cartridge with it.
After printing, the ink must dry to become functional. When printing over paper and textiles, the ink is easily absorbed, and drying is not usually necessary, however, when using polymeric substrates it is preferable to promote the drying of the ink by thermal or UV curing [104]. In the case of thermal curing, heat is applied to facilitate the evaporation of the liquid ink carrier, which can be water or organic solvent. To render high printing quality and good electrical conductivity the curing temperature needs to be carefully chosen to prevent deformation, melting, or degradation of the substrate, as well as preserve the ink properties and avoid cracking [89]. To assure the homogeneous heating of the final printed patterns, an oven or an environmental chamber is usually used. Alternatively, cross-linkable inks are instantaneously cured using UV irradiation.
Regarding the drying of the ink itself, residual tensions might cause the ink not to dry homogeneously, leading to a phenomenon known as the coffee ring effect, which impairs the quality of the final print and is pictured in Figure 6. The coffee ring effect is characterized by a ring-like morphology formed during ink evaporation, resulting from the solute segregation and accumulation along the drop periphery due to capillary flow. This issue occurs frequently when using nanoparticle inks and is caused by the convective macroscopic flow (Marangori flow) that occurs during the drying process and pushes the particles to the borders of the printed fluid [107], causing irregularities in thickness or coalescence between printed droplets.
Ring formation in colloidal droplets dried at room temperature versus uniform particle deposition of evaporating the same colloidal system in an environmental chamber at an elevated temperature. Reproduced with permission from refs. [
Factors that influence the coffee ring effect are the evaporation rate and the particle concentration in the ink. A lower evaporation rate promotes ink homogeneity and can be reduced by lowering substrate temperature. Thus, the drying temperature and time also need to be optimized. Moreover, superficial cleaning, treatment, and heating must be performed homogeneously throughout the entire surface of interest. Since the ink starts its drying process as soon as it hits the substrate, the final curing step in the oven might not be sufficient to grant homogeneous drying. As a result, some printers encompass an integrated substrate heating feature, which can facilitate the bonding of the ink to the substrate and in between layers (when more than one layer of ink is printed). Using a solvent with a high boiling point, adding additives, reducing drop volume, and increasing the particle diameter can also help reduce the coffee ring effect.
Features | ||||||
---|---|---|---|---|---|---|
System Type | Examples | Max. Jetting Frequency (kHz) | Print Width (mm) | Dropplet Volume (pL) | Resolution (dpi) | Number of nozzles |
Printheads for industrial applications | Xaar, Hitachi Ricoh, Konica Minolta, Kyocera | 45–100 | 72–116 | 1.5–21 | 360–400 | 1024–5680 |
Laboratory and research systems | Microdrop,Microfab, Fujifilm Dimatix | 30 | 64.96 | 12–33 | 1200 | 1024 |
The general inkjet printer setup can be seen in Figure 7a. A 3-degree of freedom (DOF) system is the most frequently adopted and allows for efficient printing. Usually, the printhead only prints in one of the directions x-y directions (left-to-right).
(a) Illustration of the XYZ cartesian inkjet printing system with mounted printhead. (b) Depiction of the Printhead in its native position and rotated at a 30-degree angle [
In an inkjet printer the following parameters can be adjusted:
In practice, higher resolution is associated with a higher density of drops per area, which in turn, provides higher conductivity when printing conductive inks. Nonetheless, some issues might arise when the drops are too distanced (low resolution) or too overlapped (high resolution) and printing errors such as flooding, lack of superficial homogeneity, and loss of conductivity can occur, as illustrated in Figure 8. Moreover, if several passes are demanded additional attention must be given to assure correct angle alignment [109]. Some designs can also be prone to variability and errors, particularly if the image has sharp right-angle corners or lines whose width does not obey critical spacing rules [108].
Illustration evidencing the relationship between dot spacing and morphology of printed lines. (a) Large dot spacing caused drops to be isolated from each other. (b) Less drop spacing merges drops but their round edges are still visible. (c) Ideally merged drops forming a homogeneously printed line. (d and e) low drop spacing causing localized bleeding and coffee ring effect at the edges of the printed line, respectively. Reprinted with permission from [
Since inkjet printers usually print exclusively when moving in the left–right direction, different orientations of the same patterns may experience differences in the quality output, especially when higher resolutions are involved (> native resolution). This is particularly noticeable if the manual setting of the saber angle is not perfectly aligned. Considering this, to print the correct resolution in the precise position, the inkjet printer software is programmed to compensate for the angular displacement of the head. When this happens, even a slight imprecision during the printhead assembly can propagate printing errors across several printing passes (In Table 5, the major figures of merit that allow to identify the quality of printing are summarized, along with their description and observational examples).
Figures of merit | Description | Observations |
---|---|---|
Uniformity and homogeneity | Uniformity relates to ink thickness and width irregularities (e.g., line width, raggedness, blurriness). Homogeneity is linked to distribution of ink in the printed pattern area. | Coffee ring effect is an ink inhomogeneity feature. The size of a printed line depends on drop volume and droplet-substrate interactions. Typically, printed line width is higher that the design value. Ink thickness is measured by profilometry or confocal microscopy. Its morphology by optical or SEM. Image analyzer are used for quantitative characterization. Inconsistency due to misfiring, nozzle-plate flooding and satellite drop formation (related to the ink rheology and surface tension) |
Consistency | Consistency of ink flow guaranteeing a constant process (drop volume, full dot drop) | |
Resolution | Capacity to reproduce printed pattern details | Addressability (dpi, lpi of a inkjet printer or npi of a printhead); dot spacing; sharpness and contrast; |
Drop placement error | Difference between the target and impact locations, related to printing accuracy and precision. | Error influenced by the precision of the nozzle manufacturing and the nozzle-substrate distance. |
Repeatability | Agreement between successive measurements of drop placement | Can be tested through observation or electrical conductivity measurements (consistent for the same patterns over different prints) |
Wettability | Preference of a fluid to maximize the surface contact with the substrate and spread over it | Weber number, Z number, contact angle, surface tension |
Adhesion | Adhesion of the ink to the substrate and cohesion between layers | Surface tension, surface energy of the substrate, topography of substrate |
Electrical resistivity | Can be measured as surface or volume resistivities | Two-point probes method or Van der Paw method (for better accuracy) |
Electromechanical behavior | Deformability of the printed pattern | Gauge factor; geometrical layout of printed pattern |
Ink fracture | Crackling of the deposited ink | Optical analysis |
Flexibility/stretchability | How much the ink is able to deform and return to its native state without losing its properties | Intrinsically flexible/stretchable inks; Flexible/stretchable substrates; design of patterns to withstand repetitive stress loading |
Summary of figures of merit used to classify the quality of the inkjet printing process.
(a) Simple depiction of a waveform. (I) Negative pulse that eliminates residual oscillations after each drop ejection; (II) and (III) are the pressurization and ejection phase, respectively; (b) nozzle pressure chamber as the piezoelectric crystal (darker blue) deforms due to step (III) [
Jetting behavior with increasing frequency. Reprinted from [
(a) IJP metal track generation along the x-axis (mask-less): From a CAD layout drawing (a vector file) to a binary plane (a bmp file) and from the binary plane to a physical substrate surface. (b) a unidirectional IJP system. (c) Microscopic images of the two printed lines with varying vector spacings from 190 to 450 μm (scale bar is 500 μm).
Fabrication of PE devices using IJP faces a series of challenges for enhancing the technology merit indicators, which are application dependent. These relate mainly to printing quality indicators (printed pattern homogeneity, resolution, consistency), electrical conductivity, mechanical durability, and device flexibility/stretchability. In IJP, the printing quality involves complicated interactions between many factors including the printer, the printhead, the substrate, and the ink [49].
Printed pattern resolution and uniformity are determined by droplet-substrate interactions, ink solvent evaporation rate, and capillary flow inside the ink droplet. The printed lines’ dimensions, namely their width, depend upon the drop spacing and coalescing time. There is a relationship between drop spacing, line width, and electrical resistance. The electrical resistance is directly proportional to the drop spacing and inversely proportional to the line width.
IJP is already ubiquitously employed for printing decorative layers of products. In addition to this, during the past decade, it has also started to establish itself as a low-cost manufacturing process for large-area electronics applied to smart devices [43, 50]. As previously stated, potential markets include the development of electrodes and charge transport layers for thin-film devices, energy storage devices, electronic textiles, wearables, and smart tags and sensors for remote monitoring and logistics of marketable goods. In some of these cases, technological advancements have already allowed products to emerge and enter the market [120, 121].
Many devices nowadays encompass screens made from transparent electrodes. These are usually obtained using metal oxides (such as ITO) and employed in light-emitting diodes (LED) devices. As stated above, however, ITO is brittle, and its exploitation and end-of-life cycle processing damaging to the environment. Hence, organic and hybrid alternatives, such as OLED and quantum-dot light-emitting diode (QLED) displays are starting to dominate the markets [122]. Thanks to the characteristics of the employed materials, inkjet printing is often a great manufacturing pathway to develop these devices [123]. As seen in Figure 12, ITO-free OLED can be obtained using inkjet-printed and low-temperature plasma-sintered Ag electrodes. A MOD ink was used to optimize the reduction effect of the plasma treatment, and the emissive layer of Super yellow was spin-coated.
Overview of the device fabrication. Reproduced from [
Regarding organic printable materials capable of replacing the ITO electrodes, PEDOT:PSS is the favored organic semiconductor. Jürgensen et al. studied the tuning of a PEDOT:PSS solution with surfactants, as a way of inkjet printing green electrodes in OLED with reduced surface tension [124]. Moreover, Cinquino et al. concluded that by granting a surface tension value of28 – 40 mN/m and adding 40 vol.% of a low-boiling-point co-solvent proper substrate wetting was granted [125]. As for inorganic materials, perovskite nanocrystal (PeNC) solutions have also been investigated as inkjet printable color conversion layers (CCL) in PeNC/OLED hybrid displays [126]. These displays are used universally in entertainment devices, including augmented and virtual reality devices with enhanced performance. Another field of application of these displays respects healthcare devices and photomedicine, in particular, in the development of displays for photodynamic therapy (PDT), which vows to attack cancer cells using specific light-emitting wavelengths [127].
Similarly, regarding OPV cells, the tendency is also to replace metal-oxide alloys with more environmentally friendly and easy to process materials. As an example, Alamri et al. developed fully-inkjet-printed hybrid perovskite photodetectors using Graphene/Perovskite/Graphene [128]. Schackmar and co-workers also came up with an approach to develop all-inkjet-printed absorbers and change transport layers [129]. As seen in Figure 13a), a p–i–n-perovskite solar cell architecture was created. The triple-cation perovskite absorber layer (TCP, brown) and the double layer ETL made of PCBM and BCP (pink and purple, respectively) were deposited by inkjet printing. Bihar et al. also developed a fully-inkjet printed alternative to develop OPV in which PEDOT:PSS was used to develop the electrodes (Figure 13b) [69].
(a) Schematic of the p–i–n-perovskite solar cell architecture with printed absorber and extraction layers. Reprinted from [
Inkjet printing technology is being vastly employed in the development of supercapacitors (SC), triboelectric nanogenerators, and batteries. Even though many challenges still have to be overcome for these devices to reach competitive performance, promising alternatives already exist [130]. For example, graphene-based solutions are vastly studied throughout the literature for IJP of supercapacitors [131, 132]. Li et al. inkjet printed disposable micro-supercapacitors (MSC) on paper using conductive inks based on the ternary composite of PEDOT:PSS, graphene quantum dots, and graphene [133]. In Figure 14, the resulting MSC are pictured in different array dispositions.
(a) Microsupercapacitor (MSC) printed on photo paper for flexibility performance test, (b) fully-printed MSC array with 4 MSC connected in series on carton paper, (c) fully-printed MSC array with 4 MSC connected in parallel on carton paper. The bus lines were printed with 17 passes. Reprinted from [
Giannakou and colleagues developed 3D conformable supercapacitors intended for epidermal energy storage. To achieve this, they inkjet-printed nickel (II) oxide active electrodes over PVA substrate. As a proof-of-concept, the SC was used on the skin of test subjects, and energy from their movements was successfully harvested to light a LED [134]. Energy harvesters can also be printed over textiles as a way of obtaining self-powered garments with sensing and monitoring abilities [135].
VARTA company has recently started to apply inkjet printing to the development of batteries to power sensors, and smart tags for intelligent packaging applications. Different electrochemical systems and electrodes can be printed in a stacked or co-planar manner depending on the envisioned design of the battery [136].
Sensors are vital to transduce physical changes into readable data. Several inkjet-able materials can be used as the functional part of sensors, whose electrical conductivity varies according to those changes and is later processed into digital outputs for monitoring. The most frequently developed physical sensors measure mechanical (pressure, force, strain), temperature, and humidity changes. Metal nanowires [137], metallic nanoparticles [138], polymer micro/nanostructures [139], CNT, and graphene have been applied to the design of piezoresistive flexible tactile sensors [140, 141, 142]. To work efficiently, the latter ones must be homogeneously dispersed in an elastomeric matrix, in concentrations above the electrical conductivity percolation threshold [143]. To produce piezoelectric pressure sensors the most used materials are piezoelectric ceramics, ceramic/polymer composites, and single crystals [144, 145]. As for capacitive sensing applications, SWNT/PDMS electrodes are effective options [145, 146]. Inkjet printing has also been extensively used to produce temperature, and humidity sensors that can be applied in standalone settings or, thanks to the development of the IoT can work as scattered sensor networks for remote and connected monitoring applications. Thanks to their inherent conformability, low-cost, biocompatibility, tunability, accuracy, and adequate sensing range, the pressure, temperature, and humidity printable sensors, have started to be applied in e-textiles and biomonitoring applications. As an example, Farooqui et al. successfully developed a smart bandage to remotely monitor chronic wounds through inkjet printing of a resistive sensor sensitive to pH [147].
Wearables and electronic textiles can be used for applications ranging from human-machine interaction (HMI), fashion, haptics, and biomonitoring. Regarding biomonitoring, different sensors can be inkjet-printed over textiles or conformable polymeric substrates (PDMS, PET, PEN, PEEK) and retrieve accurate biological data, thanks to the close proximity to the body. Pressure, strain [67], temperature [148], and humidity sensors [17], are the most frequently printed, nonetheless, photoplethysmography (PPG), electrocardiography (ECG), and electroencephalogram (EEG) sensors can be inkjet-printed as well [49, 135, 149, 150, 151, 152]. Electroluminescent devices can also be printed over textiles to enhance their functionality [153].
Flexible printed and biocompatible sensors placed in direct contact with the human body are also valuable for sensing specific biomarkers. This can be achieved by IJP of enzyme-functionalized inks [154]. Mass et al. enzyme-functionalized silica nanoparticles and mixed them with SWCNT to create a bio-ink with catalytic activity [154]. Biocompatible graphene-based biosensors can be printed as well to monitor the effect of antiviral drugs through impedance analysis [155]. Bihar and colleagues also developed a disposable glucose sensor by inkjet printing PEDOT:PSS as electrodes, and a glucose oxidase solution as the sensing material [156]. A dielectric ink was printed to isolate the electrode interconnects as depicted in Figure 15.
(a) Inkjet-printed glucose biosensors; (b) fully printed biosensor and identification of the different printed layers, namely the electrode (PEDOT:PSS), the dielectric, the biological coating containing the enzyme and the mediator, and the encapsulation layer. Reprinted from [
Inkjet printing can be used in the development of antennas, radio frequency identifier (RFID) chips, and near-field communication (NFC) chips, which can work as smart labels and sensor tags. Temperature, humidity, and strain sensors are usually paired with these labels to develop intelligent packaging and/or tracking applications [157, 158]. For this purpose, paper is one of the most used substrates [159]. Another important application for smart tags is food quality monitoring. By combining humidity, ammonia, temperature, and volatile organic compounds (VOC) sensors the state of perishable goods can be evaluated and the food supply chain optimized accordingly [160]. For this purpose, Quintero et al. developed a multi-sensing platform where an RFID chip was integrated with inkjet-printed sensors (ammonia, humidity, and temperature) over a PEN substrate [160]. Baubauer and co-workers also studied the printing of different types of passive tags over flexible substrates, when integrated with a rigid RFID chip, as illustrated in Figure 16 [161]. In this case, the purpose of the tags was to serve as user-interactive touch sensors. One interesting asset of these types of labels is the fact that they can be reset and reprogrammed. Since packaging is meant to be disposable, by recovering and reprogramming the tags they can be reused in other applications before being ultimately recycled [162].
Three types of printed, passive tags on a flexible substrate for operation in the UHF RFID band (902–928 MHz). Reprinted from [
IJP is a mature technology and recently has been used to print functional inks for PE devices. This novel use demanded developments in terms of new printing equipment and inks. As a result, advanced IJP technologies have emerged, responding to the requirements of novel applications. These advanced technologies are focused on increasing printing resolution and speed, printing of high viscosity inks (with higher electrical conductivity), printing over non-planar substrates, and enlarging the range of materials that can be printed.
A novel double-shot IJP technique has been developed, which allows for the deposition of two types of inks at the same position [163]. In this way, conductive and dielectric inks can be printed at the same position, allowing the construction of devices. Reactive inkjet printing, which also uses two nozzles, combines the processes of material deposition and chemical reaction to print over a substrate material, enlarging the type of ink materials.
EHD-IJP allowed high-resolution printing, paving its use in micro/nano manufacturing of electronic devices [45]. EHD-IJP is a direct patterning technique that can also be used as a thin film deposition technique (e.g., electrospraying, electrospinning). Furthermore, multi-nozzle implementation has been proposed, but nozzle density is still low [50]. EHD-IJP also allows printing of high viscosity inks and consequently has huge potential for fabricating 3D patterns [163].
Needle-based printing is a recent technology to dispense relatively high viscosity ink through a fine nozzle [50]. Droplets are ejected from the nozzle exit by the motion of the needle, which can be operated by air pressure or piezoelectric actuator. This technique can handle high viscosity inks.
Micro-plotter is a technology that also allows dispensing of relatively high viscosity ink through a fine nozzle [50]. The dispensing mechanism is based on the ultrasonic pumping action at the core of the micro-plotter head, a micropipette. The mechanism is capable of depositing ink droplets with dot size of less than 2 μm, which is smaller than an inkjet system, even when using relatively high viscosity inks (up to 450 cP).
Other droplet-based techniques have been developed, mainly for printing on non-planar substrates, such as aerosol jet printing, surpassing the limitations of both inkjet and EHD-IJP techniques. Aerosol jet printing uses high-speed ejection of aerosols instead of liquid droplets [164, 165]. The aerosol is produced by atomization of ink, which produces very small droplets with diameters in the range of 1 to 5 μm. Due to the aerodynamic effect, it also allows higher resolution for fabricating micro- and nanoscale devices. Furthermore, aerosol jetting allows different inks to be conformably printed onto the substrate.
High-resolution 3D patterning combines IJP with 3D printing technologies [166]. High-resolution insulating and conductive layers can be printed using multiple printheads in the same printing system. However, this requires a high degree of deposition precision that can be achieved by the use of phase-change inks (activated by chemical or thermal triggers) with no solvents. 3D structures can also be produced by IJP, by deposition of layer-by-layer of two reactive components, followed by polymerization. This is a technology of current intense research and fast growth.
In this chapter, the main topics concerning the IJP manufacturing of printed electronics have been discussed. Being an additive manufacturing technology, some of its advantages concern lower associated costs, material economization, and design freedom. Since its establishment as an alternative for electronics manufacturing, different variations of this technology have emerged, nonetheless, piezoelectric IJP is the most widespread method. Many functional inks have already been optimized for IJP and are commercially available. Despite this, several factors linked to the printing process can still negatively influence the printing output in terms of both printing quality and electrical conductivity and demand optimization.
As for IJP application in the current PE market, there is an undeniable growing tendency. However, it is still early to anticipate the potential of IJP technology in the long run because of all the other options currently being developed. Because of the drawbacks associated with piezoelectric IJP, namely the tendency for nozzles to clog, the limited ink viscosity range (and consequently limited electrical conductivity), and the elevated number of factors that influence the printing process, it is possible that IJP gets to be used in specific niche applications, whereas needle-based and EHD-IJP might ultimately transcend piezoelectric IJP in terms of applicability.
This work has been supported by NORTE-06-3559-FSE-000018, integrated invitation NORTE-59-2018-2041, aiming Hiring of Highly Qualified Human Resources, co-financed by the Regional Operational Programme North 2020, thematic area of Competitiveness and Employment, through the European Social Fund, and by the scope of projects with references UIDB/05256/2020 and UIDP/05256/2020, financed by FCT—Fundação para a Ciência e Tecnologia, Portugal.
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He is a full professor of signal processing and pattern recognition and is head of the Signals and Communications Department at ULPGC, teaching from 2001 on subjects on signal processing and learning theory. His research lines are biometrics, biomedical signals and images, data mining, classification system, signal and image processing, machine learning, and environmental intelligence. He has researched in 52 international and Spanish research projects, some of them as head researcher. He is co-author of 4 books, co-editor of 27 proceedings books, guest editor for 8 JCR-ISI international journals, and up to 24 book chapters. He has over 450 papers published in international journals and conferences (81 of them indexed on JCR – ISI - Web of Science). He has published seven patents in the Spanish Patent and Trademark Office. He has been a supervisor on 8 Ph.D. theses (11 more are under supervision), and 130 master theses. 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He is currently a principal researcher in data analytics and optimisation at TECNALIA (Spain), a visiting fellow at the Basque Center for Applied Mathematics (BCAM) and a part-time lecturer at the University of the Basque Country (UPV/EHU). His research interests gravitate on the use of descriptive, prescriptive and predictive algorithms for data mining and optimization in a diverse range of application fields such as Energy, Transport, Telecommunications, Health and Industry, among others. In these fields he has published more than 240 articles, co-supervised 8 Ph.D. theses, edited 6 books, coauthored 7 patents and participated/led more than 40 research projects. 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He is currently a full professor in\nthe Department of Automation and Applied Informatics at the\nsame university. Dr. Voloşencu is the author of ten books, seven\nbook chapters, and more than 160 papers published in journals\nand conference proceedings. He has also edited twelve books and\nhas twenty-seven patents to his name. He is a manager of research grants, editor in\nchief and member of international journal editorial boards, a former plenary speaker, a member of scientific committees, and chair at international conferences. His\nresearch is in the fields of control systems, control of electric drives, fuzzy control\nsystems, neural network applications, fault detection and diagnosis, sensor network\napplications, monitoring of distributed parameter systems, and power ultrasound\napplications. 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He is currently the Director of the Postgraduate Program in Implantology of the Bioface/UCAM/PgO (Montevideo, Uruguay), Director of the Cathedra of Biotechnology of the Catholic University of Murcia (Murcia, Spain), an Extraordinary Full Professor of the Catholic University of Murcia (Murcia, Spain) as well as the Director of the private center of research Biotecnos – Technology and Science (Montevideo, Uruguay). Applied biomaterials, cellular and molecular biology, and dental implants are among his research interests. He has published several original papers in renowned journals. 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She is also Invisalign certified. She’s working as a Senior Lecturer in the Department of Orthodontics, SRM Dental College since November 2019. She is actively involved in teaching orthodontics to the undergraduates and the postgraduates. Her clinical research topics include new orthodontic brackets, fixed appliances and TADs. She’s published 4 articles in well renowned indexed journals and has a published patency of her own. Her private practice is currently limited to orthodontics and works as a consultant in various clinics.",institutionString:null,institution:{name:"SRM Dental College",country:{name:"India"}}},{id:"323731",title:"Prof.",name:"Deepak M.",middleName:"Macchindra",surname:"Vikhe",slug:"deepak-m.-vikhe",fullName:"Deepak M. Vikhe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/323731/images/13613_n.jpg",biography:"Dr Deepak M.Vikhe .\n\n\t\n\tDr Deepak M.Vikhe , completed his Masters & PhD in Prosthodontics from Rural Dental College, Loni securing third rank in the Pravara Institute of Medical Sciences Deemed University. He was awarded Dr.G.C.DAS Memorial Award for Research on Implants at 39th IPS conference Dubai (U A E).He has two patents under his name. He has received Dr.Saraswati medal award for best research for implant study in 2017.He has received Fully funded scholarship to Spain ,university of Santiago de Compostela. He has completed fellowship in Implantlogy from Noble Biocare. \nHe has attended various conferences and CDE programmes and has national publications to his credit. His field of interest is in Implant supported prosthesis. Presently he is working as a associate professor in the Dept of Prosthodontics, Rural Dental College, Loni and maintains a successful private practice specialising in Implantology at Rahata.\n\nEmail: drdeepak_mvikhe@yahoo.com..................",institutionString:null,institution:{name:"Pravara Institute of Medical Sciences",country:{name:"India"}}},{id:"204110",title:"Dr.",name:"Ahmed A.",middleName:null,surname:"Madfa",slug:"ahmed-a.-madfa",fullName:"Ahmed A. Madfa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204110/images/system/204110.jpg",biography:"Dr. Madfa is currently Associate Professor of Endodontics at Thamar University and a visiting lecturer at Sana'a University and University of Sciences and Technology. He has more than 6 years of experience in teaching. 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Dr. Madfa also regularly attends international conferences and holds administrative positions (Deputy Dean of the Faculty for Students’ & Academic Affairs and Deputy Head of Research Unit).",institutionString:"Thamar University",institution:null},{id:"210472",title:"Dr.",name:"Nermin",middleName:"Mohammed Ahmed",surname:"Yussif",slug:"nermin-yussif",fullName:"Nermin Yussif",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/210472/images/system/210472.jpg",biography:"Dr. Nermin Mohammed Ahmed Yussif is working at the Faculty of dentistry, University for October university for modern sciences and arts (MSA). Her areas of expertise include: periodontology, dental laserology, oral implantology, periodontal plastic surgeries, oral mesotherapy, nutrition, dental pharmacology. She is an editor and reviewer in numerous international journals.",institutionString:"MSA University",institution:null},{id:"204606",title:"Dr.",name:"Serdar",middleName:null,surname:"Gözler",slug:"serdar-gozler",fullName:"Serdar Gözler",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/204606/images/system/204606.jpeg",biography:"Dr. Serdar Gözler has completed his undergraduate studies at the Marmara University Faculty of Dentistry in 1978, followed by an assistantship in the Prosthesis Department of Dicle University Faculty of Dentistry. Starting his PhD work on non-resilient overdentures with Assoc. Prof. Hüsnü Yavuzyılmaz, he continued his studies with Prof. Dr. Gürbüz Öztürk of Istanbul University Faculty of Dentistry Department of Prosthodontics, this time on Gnatology. He attended training programs on occlusion, neurology, neurophysiology, EMG, radiology and biostatistics. In 1982, he presented his PhD thesis \\Gerber and Lauritzen Occlusion Analysis Techniques: Diagnosis Values,\\ at Istanbul University School of Dentistry, Department of Prosthodontics. As he was also working with Prof. Senih Çalıkkocaoğlu on The Physiology of Chewing at the same time, Gözler has written a chapter in Çalıkkocaoğlu\\'s book \\Complete Prostheses\\ entitled \\The Place of Neuromuscular Mechanism in Prosthetic Dentistry.\\ The book was published five times since by the Istanbul University Publications. Having presented in various conferences about occlusion analysis until 1998, Dr. Gözler has also decided to use the T-Scan II occlusion analysis method. Having been personally trained by Dr. Robert Kerstein on this method, Dr. Gözler has been lecturing on the T-Scan Occlusion Analysis Method in conferences both in Turkey and abroad. Dr. Gözler has various articles and presentations on Digital Occlusion Analysis methods. He is now Head of the TMD Clinic at Prosthodontic Department of Faculty of Dentistry , Istanbul Aydın University , Turkey.",institutionString:"Istanbul Aydin University",institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"256417",title:"Associate Prof.",name:"Sanaz",middleName:null,surname:"Sadry",slug:"sanaz-sadry",fullName:"Sanaz Sadry",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256417/images/8106_n.jpg",biography:null,institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"240870",title:"Ph.D.",name:"Alaa Eddin Omar",middleName:null,surname:"Al Ostwani",slug:"alaa-eddin-omar-al-ostwani",fullName:"Alaa Eddin Omar Al Ostwani",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/240870/images/system/240870.jpeg",biography:"Dr. Al Ostwani Alaa Eddin Omar received his Master in dentistry from Damascus University in 2010, and his Ph.D. in Pediatric Dentistry from Damascus University in 2014. Dr. Al Ostwani is an assistant professor and faculty member at IUST University since 2014. \nDuring his academic experience, he has received several awards including the scientific research award from the Union of Arab Universities, the Syrian gold medal and the international gold medal for invention and creativity. Dr. Al Ostwani is a Member of the International Association of Dental Traumatology and the Syrian Society for Research and Preventive Dentistry since 2017. He is also a Member of the Reviewer Board of International Journal of Dental Medicine (IJDM), and the Indian Journal of Conservative and Endodontics since 2016.",institutionString:"International University for Science and Technology.",institution:{name:"Islamic University of Science and Technology",country:{name:"India"}}},{id:"42847",title:"Dr.",name:"Belma",middleName:null,surname:"Işik Aslan",slug:"belma-isik-aslan",fullName:"Belma Işik Aslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/42847/images/system/42847.jpg",biography:"Dr. Belma IşIk Aslan was born in 1976 in Ankara-TURKEY. After graduating from TED Ankara College in 1994, she attended to Gazi University, Faculty of Dentistry in Ankara. She completed her PhD in orthodontic education at Gazi University between 1999-2005. Dr. Işık Aslan stayed at the Providence Hospital Craniofacial Institude and Reconstructive Surgery in Michigan, USA for three months as an observer. She worked as a specialist doctor at Gazi University, Dentistry Faculty, Department of Orthodontics between 2005-2014. She was appointed as associate professor in January, 2014 and as professor in 2021. Dr. Işık Aslan still works as an instructor at the same faculty. She has published a total of 35 articles, 10 book chapters, 39 conference proceedings both internationally and nationally. Also she was the academic editor of the international book 'Current Advances in Orthodontics'. She is a member of the Turkish Orthodontic Society and Turkish Cleft Lip and Palate Society. She is married and has 2 children. Her knowledge of English is at an advanced level.",institutionString:"Gazi University Dentistry Faculty Department of Orthodontics",institution:null},{id:"202198",title:"Dr.",name:"Buket",middleName:null,surname:"Aybar",slug:"buket-aybar",fullName:"Buket Aybar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/202198/images/6955_n.jpg",biography:"Buket Aybar, DDS, PhD, was born in 1971. She graduated from Istanbul University, Faculty of Dentistry, in 1992 and completed her PhD degree on Oral and Maxillofacial Surgery in Istanbul University in 1997.\r\nDr. Aybar is currently a full-time professor in Istanbul University, Faculty of Dentistry Department of Oral and Maxillofacial Surgery. She has teaching responsibilities in graduate and postgraduate programs. Her clinical practice includes mainly dentoalveolar surgery.\r\nHer topics of interest are biomaterials science and cell culture studies. She has many articles in international and national scientific journals and chapters in books; she also has participated in several scientific projects supported by Istanbul University Research fund.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178412",title:"Associate Prof.",name:"Guhan",middleName:null,surname:"Dergin",slug:"guhan-dergin",fullName:"Guhan Dergin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178412/images/6954_n.jpg",biography:"Assoc. Prof. Dr. Gühan Dergin was born in 1973 in Izmit. He graduated from Marmara University Faculty of Dentistry in 1999. He completed his specialty of OMFS surgery in Marmara University Faculty of Dentistry and obtained his PhD degree in 2006. In 2005, he was invited as a visiting doctor in the Oral and Maxillofacial Surgery Department of the University of North Carolina, USA, where he went on a scholarship. Dr. Dergin still continues his academic career as an associate professor in Marmara University Faculty of Dentistry. He has many articles in international and national scientific journals and chapters in books.",institutionString:null,institution:{name:"Marmara University",country:{name:"Turkey"}}},{id:"178414",title:"Prof.",name:"Yusuf",middleName:null,surname:"Emes",slug:"yusuf-emes",fullName:"Yusuf Emes",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178414/images/6953_n.jpg",biography:"Born in Istanbul in 1974, Dr. Emes graduated from Istanbul University Faculty of Dentistry in 1997 and completed his PhD degree in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery in 2005. He has papers published in international and national scientific journals, including research articles on implantology, oroantral fistulas, odontogenic cysts, and temporomandibular disorders. Dr. Emes is currently working as a full-time academic staff in Istanbul University faculty of Dentistry Department of Oral and Maxillofacial Surgery.",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"192229",title:"Ph.D.",name:"Ana Luiza",middleName:null,surname:"De Carvalho Felippini",slug:"ana-luiza-de-carvalho-felippini",fullName:"Ana Luiza De Carvalho Felippini",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192229/images/system/192229.jpg",biography:null,institutionString:"University of São Paulo",institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"256851",title:"Prof.",name:"Ayşe",middleName:null,surname:"Gülşen",slug:"ayse-gulsen",fullName:"Ayşe Gülşen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/256851/images/9696_n.jpg",biography:"Dr. Ayşe Gülşen graduated in 1990 from Faculty of Dentistry, University of Ankara and did a postgraduate program at University of Gazi. \nShe worked as an observer and research assistant in Craniofacial Surgery Departments in New York, Providence Hospital in Michigan and Chang Gung Memorial Hospital in Taiwan. \nShe works as Craniofacial Orthodontist in Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi, Ankara Turkey since 2004.",institutionString:"Orthodontist, Assoc Prof in the Department of Aesthetic, Plastic and Reconstructive Surgery, Faculty of Medicine, University of Gazi",institution:null},{id:"255366",title:"Prof.",name:"Tosun",middleName:null,surname:"Tosun",slug:"tosun-tosun",fullName:"Tosun Tosun",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255366/images/7347_n.jpg",biography:"Graduated at the Faculty of Dentistry, University of Istanbul, Turkey in 1989;\nVisitor Assistant at the University of Padua, Italy and Branemark Osseointegration Center of Treviso, Italy between 1993-94;\nPhD thesis on oral implantology in University of Istanbul and was awarded the academic title “Dr.med.dent.”, 1997;\nHe was awarded the academic title “Doç.Dr.” (Associated Professor) in 2003;\nProficiency in Botulinum Toxin Applications, Reading-UK in 2009;\nMastership, RWTH Certificate in Laser Therapy in Dentistry, AALZ-Aachen University, Germany 2009-11;\nMaster of Science (MSc) in Laser Dentistry, University of Genoa, Italy 2013-14.\n\nDr.Tosun worked as Research Assistant in the Department of Oral Implantology, Faculty of Dentistry, University of Istanbul between 1990-2002. \nHe worked part-time as Consultant surgeon in Harvard Medical International Hospitals and John Hopkins Medicine, Istanbul between years 2007-09.\u2028He was contract Professor in the Department of Surgical and Diagnostic Sciences (DI.S.C.), Medical School, University of Genova, Italy between years 2011-16. \nSince 2015 he is visiting Professor at Medical School, University of Plovdiv, Bulgaria. \nCurrently he is Associated Prof.Dr. at the Dental School, Oral Surgery Dept., Istanbul Aydin University and since 2003 he works in his own private clinic in Istanbul, Turkey.\u2028\nDr.Tosun is reviewer in journal ‘Laser in Medical Sciences’, reviewer in journal ‘Folia Medica\\', a Fellow of the International Team for Implantology, Clinical Lecturer of DGZI German Association of Oral Implantology, Expert Lecturer of Laser&Health Academy, Country Representative of World Federation for Laser Dentistry, member of European Federation of Periodontology, member of Academy of Laser Dentistry. Dr.Tosun presents papers in international and national congresses and has scientific publications in international and national journals. He speaks english, spanish, italian and french.",institutionString:null,institution:{name:"Istanbul Aydın University",country:{name:"Turkey"}}},{id:"260116",title:"Dr.",name:"Mehmet",middleName:null,surname:"Yaltirik",slug:"mehmet-yaltirik",fullName:"Mehmet Yaltirik",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/260116/images/7413_n.jpg",biography:"Birth Date 25.09.1965\r\nBirth Place Adana- Turkey\r\nSex Male\r\nMarrial Status Bachelor\r\nDriving License Acquired\r\nMother Tongue Turkish\r\n\r\nAddress:\r\nWork:University of Istanbul,Faculty of Dentistry, Department of Oral Surgery and Oral Medicine 34093 Capa,Istanbul- TURKIYE",institutionString:null,institution:{name:"Istanbul University",country:{name:"Turkey"}}},{id:"171887",title:"Prof.",name:"Zühre",middleName:null,surname:"Akarslan",slug:"zuhre-akarslan",fullName:"Zühre Akarslan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/171887/images/system/171887.jpg",biography:"Zühre Akarslan was born in 1977 in Cyprus. She graduated from Gazi University Faculty of Dentistry, Ankara, Turkey in 2000. \r\nLater she received her Ph.D. degree from the Oral Diagnosis and Radiology Department; which was recently renamed as Oral and Dentomaxillofacial Radiology, from the same university. \r\nShe is working as a full-time Associate Professor and is a lecturer and an academic researcher. \r\nHer expertise areas are dental caries, cancer, dental fear and anxiety, gag reflex in dentistry, oral medicine, and dentomaxillofacial radiology.",institutionString:"Gazi University",institution:{name:"Gazi University",country:{name:"Turkey"}}},{id:"272237",title:"Dr.",name:"Pinar",middleName:"Kiymet",surname:"Karataban",slug:"pinar-karataban",fullName:"Pinar Karataban",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/272237/images/8911_n.png",biography:"Assist.Prof.Dr.Pınar Kıymet Karataban, DDS PhD \n\nDr.Pınar Kıymet Karataban was born in Istanbul in 1975. After her graduation from Marmara University Faculty of Dentistry in 1998 she started her PhD in Paediatric Dentistry focused on children with special needs; mainly children with Cerebral Palsy. She finished her pHD thesis entitled \\'Investigation of occlusion via cast analysis and evaluation of dental caries prevalance, periodontal status and muscle dysfunctions in children with cerebral palsy” in 2008. She got her Assist. Proffessor degree in Istanbul Aydın University Paediatric Dentistry Department in 2015-2018. ın 2019 she started her new career in Bahcesehir University, Istanbul as Head of Department of Pediatric Dentistry. In 2020 she was accepted to BAU International University, Batumi as Professor of Pediatric Dentistry. She’s a lecturer in the same university meanwhile working part-time in private practice in Ege Dental Studio (https://www.egedisklinigi.com/) a multidisciplinary dental clinic in Istanbul. Her main interests are paleodontology, ancient and contemporary dentistry, oral microbiology, cerebral palsy and special care dentistry. She has national and international publications, scientific reports and is a member of IAPO (International Association for Paleodontology), IADH (International Association of Disability and Oral Health) and EAPD (European Association of Pediatric Dentistry).",institutionString:null,institution:null},{id:"172009",title:"Dr.",name:"Fatma Deniz",middleName:null,surname:"Uzuner",slug:"fatma-deniz-uzuner",fullName:"Fatma Deniz Uzuner",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/172009/images/7122_n.jpg",biography:"Dr. Deniz Uzuner was born in 1969 in Kocaeli-TURKEY. After graduating from TED Ankara College in 1986, she attended the Hacettepe University, Faculty of Dentistry in Ankara. \nIn 1993 she attended the Gazi University, Faculty of Dentistry, Department of Orthodontics for her PhD education. After finishing the PhD education, she worked as orthodontist in Ankara Dental Hospital under the Turkish Government, Ministry of Health and in a special Orthodontic Clinic till 2011. Between 2011 and 2016, Dr. Deniz Uzuner worked as a specialist in the Department of Orthodontics, Faculty of Dentistry, Gazi University in Ankara/Turkey. In 2016, she was appointed associate professor. Dr. Deniz Uzuner has authored 23 Journal Papers, 3 Book Chapters and has had 39 oral/poster presentations. She is a member of the Turkish Orthodontic Society. Her knowledge of English is at an advanced level.",institutionString:null,institution:null},{id:"332914",title:"Dr.",name:"Muhammad Saad",middleName:null,surname:"Shaikh",slug:"muhammad-saad-shaikh",fullName:"Muhammad Saad Shaikh",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Jinnah Sindh Medical University",country:{name:"Pakistan"}}},{id:"315775",title:"Dr.",name:"Feng",middleName:null,surname:"Luo",slug:"feng-luo",fullName:"Feng Luo",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Sichuan University",country:{name:"China"}}},{id:"344229",title:"Dr.",name:"Sankeshan",middleName:null,surname:"Padayachee",slug:"sankeshan-padayachee",fullName:"Sankeshan Padayachee",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"315727",title:"Ms.",name:"Kelebogile A.",middleName:null,surname:"Mothupi",slug:"kelebogile-a.-mothupi",fullName:"Kelebogile A. Mothupi",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"423519",title:"Dr.",name:"Sizakele",middleName:null,surname:"Ngwenya",slug:"sizakele-ngwenya",fullName:"Sizakele Ngwenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"337613",title:"Mrs.",name:"Tshakane",middleName:null,surname:"R.M.D. Ralephenya",slug:"tshakane-r.m.d.-ralephenya",fullName:"Tshakane R.M.D. Ralephenya",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of the Witwatersrand",country:{name:"South Africa"}}},{id:"419270",title:"Dr.",name:"Ann",middleName:null,surname:"Chianchitlert",slug:"ann-chianchitlert",fullName:"Ann Chianchitlert",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419271",title:"Dr.",name:"Diane",middleName:null,surname:"Selvido",slug:"diane-selvido",fullName:"Diane Selvido",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}},{id:"419272",title:"Dr.",name:"Irin",middleName:null,surname:"Sirisoontorn",slug:"irin-sirisoontorn",fullName:"Irin Sirisoontorn",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Walailak University",country:{name:"Thailand"}}}]}},subseries:{item:{id:"14",type:"subseries",title:"Cell and Molecular Biology",keywords:"Omics (Transcriptomics; Proteomics; Metabolomics), Molecular Biology, Cell Biology, Signal Transduction and Regulation, Cell Growth and Differentiation, Apoptosis, Necroptosis, Ferroptosis, Autophagy, Cell Cycle, Macromolecules and Complexes, Gene Expression",scope:"The Cell and Molecular Biology topic within the IntechOpen Biochemistry Series aims to rapidly publish contributions on all aspects of cell and molecular biology, including aspects related to biochemical and genetic research (not only in humans but all living beings). We encourage the submission of manuscripts that provide novel and mechanistic insights that report significant advances in the fields. Topics include, but are not limited to: Advanced techniques of cellular and molecular biology (Molecular methodologies, imaging techniques, and bioinformatics); Biological activities at the molecular level; Biological processes of cell functions, cell division, senescence, maintenance, and cell death; Biomolecules interactions; Cancer; Cell biology; Chemical biology; Computational biology; Cytochemistry; Developmental biology; Disease mechanisms and therapeutics; DNA, and RNA metabolism; Gene functions, genetics, and genomics; Genetics; Immunology; Medical microbiology; Molecular biology; Molecular genetics; Molecular processes of cell and organelle dynamics; Neuroscience; Protein biosynthesis, degradation, and functions; Regulation of molecular interactions in a cell; Signalling networks and system biology; Structural biology; Virology and microbiology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/14.jpg",hasOnlineFirst:!0,hasPublishedBooks:!0,annualVolume:11410,editor:{id:"165627",title:"Dr.",name:"Rosa María",middleName:null,surname:"Martínez-Espinosa",slug:"rosa-maria-martinez-espinosa",fullName:"Rosa María Martínez-Espinosa",profilePictureURL:"https://mts.intechopen.com/storage/users/165627/images/system/165627.jpeg",biography:"Dr. Rosa María Martínez-Espinosa has been a Spanish Full Professor since 2020 (Biochemistry and Molecular Biology) and is currently Vice-President of International Relations and Cooperation development and leader of the research group 'Applied Biochemistry” (University of Alicante, Spain). Other positions she has held at the university include Vice-Dean of Master Programs, Vice-Dean of the Degree in Biology and Vice-Dean for Mobility and Enterprise and Engagement at the Faculty of Science (University of Alicante). She received her Bachelor in Biology in 1998 (University of Alicante) and her PhD in 2003 (Biochemistry, University of Alicante). She undertook post-doctoral research at the University of East Anglia (Norwich, U.K. 2004-2005; 2007-2008).\nHer multidisciplinary research focuses on investigating archaea and their potential applications in biotechnology. She has an H-index of 21. She has authored one patent and has published more than 70 indexed papers and around 60 book chapters.\nShe has contributed to more than 150 national and international meetings during the last 15 years. Her research interests include archaea metabolism, enzymes purification and characterization, gene regulation, carotenoids and bioplastics production, antioxidant\ncompounds, waste water treatments, and brines bioremediation.\nRosa María’s other roles include editorial board member for several journals related\nto biochemistry, reviewer for more than 60 journals (biochemistry, molecular biology, biotechnology, chemistry and microbiology) and president of several organizing committees in international meetings related to the N-cycle or respiratory processes.",institutionString:null,institution:{name:"University of Alicante",institutionURL:null,country:{name:"Spain"}}},editorTwo:null,editorThree:null,series:{id:"11",title:"Biochemistry",doi:"10.5772/intechopen.72877",issn:"2632-0983"},editorialBoard:[{id:"79367",title:"Dr.",name:"Ana Isabel",middleName:null,surname:"Flores",slug:"ana-isabel-flores",fullName:"Ana Isabel Flores",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bRpIOQA0/Profile_Picture_1632418099564",institutionString:null,institution:{name:"Hospital Universitario 12 De Octubre",institutionURL:null,country:{name:"Spain"}}},{id:"328234",title:"Ph.D.",name:"Christian",middleName:null,surname:"Palavecino",slug:"christian-palavecino",fullName:"Christian Palavecino",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000030DhEhQAK/Profile_Picture_1628835318625",institutionString:null,institution:{name:"Central University of Chile",institutionURL:null,country:{name:"Chile"}}},{id:"186585",title:"Dr.",name:"Francisco Javier",middleName:null,surname:"Martin-Romero",slug:"francisco-javier-martin-romero",fullName:"Francisco Javier Martin-Romero",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bSB3HQAW/Profile_Picture_1631258137641",institutionString:null,institution:{name:"University of Extremadura",institutionURL:null,country:{name:"Spain"}}}]},onlineFirstChapters:{paginationCount:17,paginationItems:[{id:"82751",title:"Mitochondria-Endoplasmic Reticulum Interaction in Central Neurons",doi:"10.5772/intechopen.105738",signatures:"Liliya Kushnireva and Eduard Korkotian",slug:"mitochondria-endoplasmic-reticulum-interaction-in-central-neurons",totalDownloads:6,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82716",title:"Advanced glycation end product induced endothelial dysfunction through ER stress: Unravelling the role of Paraoxonase 2",doi:"10.5772/intechopen.106018",signatures:"Ramya Ravi and Bharathidevi Subramaniam Rajesh",slug:"advanced-glycation-end-product-induced-endothelial-dysfunction-through-er-stress-unravelling-the-rol",totalDownloads:13,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82195",title:"Endoplasmic Reticulum: A Hub in Lipid Homeostasis",doi:"10.5772/intechopen.105450",signatures:"Raúl Ventura and María Isabel Hernández-Alvarez",slug:"endoplasmic-reticulum-a-hub-in-lipid-homeostasis",totalDownloads:17,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"82103",title:"The Role of Endoplasmic Reticulum Stress and Its Regulation in the Progression of Neurological and Infectious Diseases",doi:"10.5772/intechopen.105543",signatures:"Mary Dover, Michael Kishek, Miranda Eddins, Naneeta Desar, Ketema Paul and Milan Fiala",slug:"the-role-of-endoplasmic-reticulum-stress-and-its-regulation-in-the-progression-of-neurological-and-i",totalDownloads:15,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Updates on Endoplasmic Reticulum",coverURL:"https://cdn.intechopen.com/books/images_new/11674.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"80954",title:"Ion Channels and Neurodegenerative Disease Aging Related",doi:"10.5772/intechopen.103074",signatures:"Marika Cordaro, Salvatore Cuzzocrea and Rosanna Di Paola",slug:"ion-channels-and-neurodegenerative-disease-aging-related",totalDownloads:12,totalCrossrefCites:0,totalDimensionsCites:0,authors:null,book:{title:"Ion Channels - From Basic Properties to Medical Treatment",coverURL:"https://cdn.intechopen.com/books/images_new/10838.jpg",subseries:{id:"14",title:"Cell and Molecular Biology"}}},{id:"81647",title:"Diabetes and Epigenetics",doi:"10.5772/intechopen.104653",signatures:"Rasha A. 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