Comparative results obtained using new DAQB and different apparatus.
\\n\\n
IntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\\n\\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\\n\\nLaunching 2021
\\n\\nArtificial Intelligence, ISSN 2633-1403
\\n\\nVeterinary Medicine and Science, ISSN 2632-0517
\\n\\nBiochemistry, ISSN 2632-0983
\\n\\nBiomedical Engineering, ISSN 2631-5343
\\n\\nInfectious Diseases, ISSN 2631-6188
\\n\\nPhysiology (Coming Soon)
\\n\\nDentistry (Coming Soon)
\\n\\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\\n\\nNote: Edited in October 2021
\\n"}]',published:!0,mainMedia:{caption:"",originalUrl:"/media/original/132"}},components:[{type:"htmlEditorComponent",content:'With the desire to make book publishing more relevant for the digital age and offer innovative Open Access publishing options, we are thrilled to announce the launch of our new publishing format: IntechOpen Book Series.
\n\nDesigned to cover fast-moving research fields in rapidly expanding areas, our Book Series feature a Topic structure allowing us to present the most relevant sub-disciplines. Book Series are headed by Series Editors, and a team of Topic Editors supported by international Editorial Board members. Topics are always open for submissions, with an Annual Volume published each calendar year.
\n\nAfter a robust peer-review process, accepted works are published quickly, thanks to Online First, ensuring research is made available to the scientific community without delay.
\n\nOur innovative Book Series format brings you:
\n\nIntechOpen Book Series will also publish a program of research-driven Thematic Edited Volumes that focus on specific areas and allow for a more in-depth overview of a particular subject.
\n\nIntechOpen Book Series will be launching regularly to offer our authors and editors exciting opportunities to publish their research Open Access. We will begin by relaunching some of our existing Book Series in this innovative book format, and will expand in 2022 into rapidly growing research fields that are driving and advancing society.
\n\nLaunching 2021
\n\nArtificial Intelligence, ISSN 2633-1403
\n\nVeterinary Medicine and Science, ISSN 2632-0517
\n\nBiochemistry, ISSN 2632-0983
\n\nBiomedical Engineering, ISSN 2631-5343
\n\nInfectious Diseases, ISSN 2631-6188
\n\nPhysiology (Coming Soon)
\n\nDentistry (Coming Soon)
\n\nWe invite you to explore our IntechOpen Book Series, find the right publishing program for you and reach your desired audience in record time.
\n\nNote: Edited in October 2021
\n'}],latestNews:[{slug:"webinar-introduction-to-open-science-wednesday-18-may-1-pm-cest-20220518",title:"Webinar: Introduction to Open Science | Wednesday 18 May, 1 PM CEST"},{slug:"step-in-the-right-direction-intechopen-launches-a-portfolio-of-open-science-journals-20220414",title:"Step in the Right Direction: IntechOpen Launches a Portfolio of Open Science Journals"},{slug:"let-s-meet-at-london-book-fair-5-7-april-2022-olympia-london-20220321",title:"Let’s meet at London Book Fair, 5-7 April 2022, Olympia London"},{slug:"50-books-published-as-part-of-intechopen-and-knowledge-unlatched-ku-collaboration-20220316",title:"50 Books published as part of IntechOpen and Knowledge Unlatched (KU) Collaboration"},{slug:"intechopen-joins-the-united-nations-sustainable-development-goals-publishers-compact-20221702",title:"IntechOpen joins the United Nations Sustainable Development Goals Publishers Compact"},{slug:"intechopen-signs-exclusive-representation-agreement-with-lsr-libros-servicios-y-representaciones-s-a-de-c-v-20211123",title:"IntechOpen Signs Exclusive Representation Agreement with LSR Libros Servicios y Representaciones S.A. de C.V"},{slug:"intechopen-expands-partnership-with-research4life-20211110",title:"IntechOpen Expands Partnership with Research4Life"},{slug:"introducing-intechopen-book-series-a-new-publishing-format-for-oa-books-20210915",title:"Introducing IntechOpen Book Series - A New Publishing Format for OA Books"}]},book:{item:{type:"book",id:"7377",leadTitle:null,fullTitle:"Diesel and Gasoline Engines",title:"Diesel and Gasoline Engines",subtitle:null,reviewType:"peer-reviewed",abstract:"The internal combustion engine was invented around 1790 by various scientists and engineers worldwide. Since then the engines have gone through many modifications and improvements. Today, different applications of engines form a significant technological importance in our everyday lives, leading to the evolution of our modern civilization. The invention of diesel and gasoline engines has definitely changed our lifestyles as well as shaped our priorities. The current engines serve innumerable applications in various types of transportation, in harsh environments, in construction, in diverse industries, and also as back-up power supply systems for hospitals, security departments, and other institutions. However, heavy duty or light duty engines have certain major disadvantages, which are well known to everyone. With the increasing usage of diesel and gasoline engines, and the constantly rising number of vehicles worldwide, the main concern nowadays is engine exhaust emissions. This book looks at basic phenomena related to diesel and gasoline engines, combustion, alternative fuels, exhaust emissions, and mitigations.",isbn:"978-1-78985-447-3",printIsbn:"978-1-78985-248-6",pdfIsbn:"978-1-78985-448-0",doi:"10.5772/intechopen.75259",price:119,priceEur:129,priceUsd:155,slug:"diesel-and-gasoline-engines",numberOfPages:200,isOpenForSubmission:!1,isInWos:null,isInBkci:!1,hash:"dab9fe312a28dd603ac4b21628070d59",bookSignature:"Richard Viskup",publishedDate:"February 26th 2020",coverURL:"https://cdn.intechopen.com/books/images_new/7377.jpg",numberOfDownloads:9802,numberOfWosCitations:13,numberOfCrossrefCitations:22,numberOfCrossrefCitationsByBook:1,numberOfDimensionsCitations:37,numberOfDimensionsCitationsByBook:3,hasAltmetrics:1,numberOfTotalCitations:72,isAvailableForWebshopOrdering:!0,dateEndFirstStepPublish:"June 6th 2019",dateEndSecondStepPublish:"June 24th 2019",dateEndThirdStepPublish:"August 20th 2019",dateEndFourthStepPublish:"November 14th 2019",dateEndFifthStepPublish:"January 13th 2020",currentStepOfPublishingProcess:5,indexedIn:"1,2,3,4,5,6,7",editedByType:"Edited by",kuFlag:!0,featuredMarkup:null,editors:[{id:"103742",title:"Dr.",name:"Richard",middleName:null,surname:"Viskup",slug:"richard-viskup",fullName:"Richard Viskup",profilePictureURL:"https://mts.intechopen.com/storage/users/103742/images/7778_n.jpg",biography:"Richard Viskup was born in Bratislava in the Slovak Republic, formerly Czechoslovakia. He received his Master of Science, Doctor in Natural Science, and Doctor of Philosophy in Physics, Plasma Physics, and Laser Physics, respectively, from Comenius University, Bratislava. He obtained his postgraduate Master of Philosophy in Photonics from Strathclyde University, Glasgow, Scotland, and a Doctor of Engineering in Applied Physics from Johannes Kepler University, Linz, Austria.\nDr. Viskup’s research interests include physics, plasma, lasers, material science and analyses, radiation physics, analytical chemistry, spectroscopy, combustion processes, and environmental science, among others.",institutionString:"Johannes Kepler University",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"5",totalChapterViews:"0",totalEditedBooks:"4",institution:{name:"Johannes Kepler University of Linz",institutionURL:null,country:{name:"Austria"}}}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"829",title:"Automobile Engineering",slug:"vehicle-engineering-automobile-engineering"}],chapters:[{id:"63346",title:"Alternative Fuels for Diesel Engines: New Frontiers",doi:"10.5772/intechopen.80614",slug:"alternative-fuels-for-diesel-engines-new-frontiers",totalDownloads:1882,totalCrossrefCites:5,totalDimensionsCites:7,hasAltmetrics:1,abstract:"The world at present is mainly dependent upon petroleum-derived fuels for meeting its energy requirement. However, perturbation in crude prices, which concerns about long-term availability of these fuels coupled with environmental degradation due to their combustion, has put renewable alternative fuels on the forefront of policy maker’s agenda. The diesel engines are considered workhorse in the global economy due to better thermal efficiency, ruggedness, and load carrying capacity. They, however, are also the main contributor to air pollution as they emit more oxides of nitrogen, suspended particulate matter as compared to gasoline engines. The most potential fuel either to supplement or to substitute diesel is biodiesel, butanol, producer gas, dimethyl ether, hydrogen, and so on. This chapter presents the developments about the use of alternative fuels in diesel engines. The exhaustive literature has evolved the main trends in the development of alternative fuels around the world. The chapter also describes the research directions on production and use of alternative fuels in off-road and transport vehicles powered by diesel engines.",signatures:"Naveen Kumar, Ankit Sonthalia, Harveer S. Pali and Sidharth",downloadPdfUrl:"/chapter/pdf-download/63346",previewPdfUrl:"/chapter/pdf-preview/63346",authors:[{id:"257741",title:"Prof.",name:"Naveen",surname:"Kumar",slug:"naveen-kumar",fullName:"Naveen Kumar"},{id:"267558",title:"Dr.",name:"Harveer Singh",surname:"Pali",slug:"harveer-singh-pali",fullName:"Harveer Singh Pali"},{id:"267559",title:"Mr.",name:"Ankit",surname:"Sonthalia",slug:"ankit-sonthalia",fullName:"Ankit Sonthalia"},{id:"267563",title:"Mr.",name:"Sidharth",surname:"Bansal",slug:"sidharth-bansal",fullName:"Sidharth Bansal"}],corrections:null},{id:"69204",title:"Fuels of the Diesel-Gasoline Engines and Their Properties",doi:"10.5772/intechopen.89044",slug:"fuels-of-the-diesel-gasoline-engines-and-their-properties",totalDownloads:1556,totalCrossrefCites:12,totalDimensionsCites:17,hasAltmetrics:0,abstract:"Hydrocarbon-based fuels which are gasoline, diesel, natural gas, and liquefied petroleum gas (LPG) have been generally used in the diesel and gasoline engines as a fuel. In this study, hydrocarbon-based fuels such as alkanes (paraffins), naphthenes (cycloparaffins), alkenes (olefins), alkynes (acetylenes), and aromatics (benzene derivatives) have been classified. Their molecular structure and properties have been comprehensively explained. In addition to this, some of the important fuel properties of the commonly used fossil-based fuels such as gasoline and diesel in the internal combustion engine have been evaluated. Thus, hydrocarbon derivative fuels which are diesel, gasoline, natural gas, and liquefied petroleum gas (LPG) have been investigated as an internal combustion engine fuel. Their physical and chemical properties were explained and compared to each other. Octane number and cetane number substantially affect the fuel ignition delay period and self-ignition temperature properties. Therefore, the gasoline and diesel engine running is dominantly affected by the octane and cetane numbers, respectively. As a result, fossil-based fuel’s physical and chemical properties, advantages, and disadvantages have been comprehensively explained and compared to each other. The fuels, which are commonly used in the diesel and gasoline engine, have been investigated, and their important properties have been revealed.",signatures:"Selçuk Sarıkoç",downloadPdfUrl:"/chapter/pdf-download/69204",previewPdfUrl:"/chapter/pdf-preview/69204",authors:[{id:"308175",title:"Dr.",name:"Selçuk",surname:"Sarıkoç",slug:"selcuk-sarikoc",fullName:"Selçuk Sarıkoç"}],corrections:null},{id:"64732",title:"Compressed Bio Gas (CBG) in Diesel Engine",doi:"10.5772/intechopen.82206",slug:"compressed-bio-gas-cbg-in-diesel-engine",totalDownloads:800,totalCrossrefCites:0,totalDimensionsCites:2,hasAltmetrics:0,abstract:"In this chapter, as an alternative to conventional engines, compressed biogas (CBG)-fueled compression ignition (CI) engine was evaluated. Biogas fuel is considerably economic due to the local product fuel compared to that of CNG and LPG fuels for many countries. In addition, due to the higher octane rate, biogas is considerably adaptable for the diesel engines. In this issue, CBG diesel-fueled engine was investigated using full geometry 3D computational fluid dynamics (CFD) simulations including intake and exhaust ports were used in optimization process to get the optimum design parameters of the CBG-diesel engine. Usage of CBG fuel in the optimized CBG engine without any constructive change in cylinder block will considerably decrease the cost. During the engine design, one-dimensional (1D) and three-dimensional (3D) CFD codes and multi-objective optimization code were employed by coupling codes. CBG and diesel fuels were defined as leading reactants using user-defined code in dual-fuel diesel engine modeling. CBG and diesel mass flow rates, start of pilot diesel fuel injection, compression ratio, valve timing, and engine speed were defined as input variables in different engine loads and evaluated about 20,000 cases to define the proper operating conditions. CBG-diesel engine and significantly lower NOx emissions were emitted under dual-fuel operation for all cases compared to single-fuel mode at all engine load conditions. Moreover, CBG-diesel engine provided superior performance in reductions of NOx and particulate matter (PM) emissions.",signatures:"Hasan Köten",downloadPdfUrl:"/chapter/pdf-download/64732",previewPdfUrl:"/chapter/pdf-preview/64732",authors:[{id:"255428",title:"Prof.",name:"Hasan",surname:"Koten",slug:"hasan-koten",fullName:"Hasan Koten"}],corrections:null},{id:"69324",title:"Hydrogen Fumigation on HD Diesel Engine: An Experimental and Numerical Study",doi:"10.5772/intechopen.89425",slug:"hydrogen-fumigation-on-hd-diesel-engine-an-experimental-and-numerical-study",totalDownloads:811,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:0,abstract:"The currently reported work was concerned with experimental and numerical evaluation of the potential to partially replace diesel with hydrogen fuel, which continues to attract attention as an alternative longer-term fuel solution. The experimental work was involved with the fumigation of hydrogen on a single cylinder HD diesel engine under two real-world driving conditions at low and mid loads. Highest practical hydrogen substitution ratios could increase indicated efficiency by up to 4.6 and 2.4% while reducing CO2 emissions by 58 and 32% at low and mid loads, respectively. Soot and CO emissions were reduced as more hydrogen was supplied, particularly at low load. The numerical study was made by using two distinct phenomenological models being run in parallel. While, an in-depth evaluation of the unique dual fuel combustion was possible, the arising errors were largely associated with lack of dual fuel burning velocity data, which will remain a key barrier to dual-fuel simulation.",signatures:"Emad Monemian and Alasdair Cairns",downloadPdfUrl:"/chapter/pdf-download/69324",previewPdfUrl:"/chapter/pdf-preview/69324",authors:[{id:"307627",title:"Dr.",name:"Emad",surname:"Monemian",slug:"emad-monemian",fullName:"Emad Monemian"},{id:"310284",title:"Prof.",name:"Alasdair",surname:"Cairns",slug:"alasdair-cairns",fullName:"Alasdair Cairns"}],corrections:null},{id:"70656",title:"Planar Drop-Sizing in Dense Fuel Sprays Using Advanced Laser Diagnostic Techniques",doi:"10.5772/intechopen.90527",slug:"planar-drop-sizing-in-dense-fuel-sprays-using-advanced-laser-diagnostic-techniques",totalDownloads:756,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"A reliable measurement of drop sizes and liquid fuel distribution in a spray is essential for best combustion efficiency and exhaust emission from I.C. engines. The droplet size and fuel distribution control air-fuel mixture formation and, hence, combustion characteristics. The chapter gives a concise summary of recent advances and developments in the LSD technique as a planar drop-sizing technique. The LSD technique relies on the principle that a ratio of planar laser-induced fluorescence (PLIF) and Mie signals is proportional to Sauter mean diameter (SMD). PLIF signal can also be used to determine the distribution of liquid in a spray. This makes LSD an attractive technique in dense spray characterization that can also provide liquid volume fraction distributions. A brief review of laser-based drop-sizing methods and working principle of LSD measurements are first discussed. Different approaches and limitations of the LSD technique are also summarized. Further, sources of error and ways to compensate these errors are explained in detail. Previous studies on LSD measurements in different fuel sprays of stationary combustion devices and I.C. engines are summarized. Finally, improvements in the LSD techniques are suggested, including structured laser illumination planar imaging (SLIPI) measurements, for reliable measurements in dense sprays.",signatures:"Aniket P. Kulkarni and D. Deshmukh",downloadPdfUrl:"/chapter/pdf-download/70656",previewPdfUrl:"/chapter/pdf-preview/70656",authors:[{id:"309850",title:"Dr.",name:"Aniket",surname:"Kulkarni",slug:"aniket-kulkarni",fullName:"Aniket Kulkarni"},{id:"311578",title:"Dr.",name:"Devendra",surname:"Deshmukh",slug:"devendra-deshmukh",fullName:"Devendra Deshmukh"}],corrections:null},{id:"69237",title:"Some Methods to Prevent the Wear of Piston-Cylinder When Using Low Sulphur Fuel Oil (LSFO) for All Ships Sailing on Emission Control Areas (ECAs)",doi:"10.5772/intechopen.89400",slug:"some-methods-to-prevent-the-wear-of-piston-cylinder-when-using-low-sulphur-fuel-oil-lsfo-for-all-shi",totalDownloads:1048,totalCrossrefCites:2,totalDimensionsCites:5,hasAltmetrics:0,abstract:"The IMO (International Maritime Organization) of MARPOL 73/78, Regulations for the Prevention of Air Pollution from Ships, has been adopted and took effect from May 2005 and had significantly to the present. The increases in a number of ships are leading to a large of number of exhaust gas emission into the environment. It is main reason that the Annex VI, MARPOL 73/78 is extremely necessary to require the ships need to comply. Furthermore, the marine fuel is used mainly for marine diesel engine nowadays, heavy fuel oil with high sulphur content. However, the IMO’s regulations show that from January 1, 2020, fuel oil that is used on board should have no more than 0.50% sulphur content in order to protect the environment. Its benefit will have positive effect to the environment. On another side, the diesel engine operation especially the corrosion phenomenon for all piston-cylinder components will have negative effect due to the use of low sulphur fuel oil (LSFO). This chapter concentrates on researching the above phenomenon and gives some methods to restrict the negative influence on using the kind of low sulphur fuel oil. The results are fundamental knowledge for all vessels to comply the regulations of MARPOL 73/78 while sailing on ECAs.",signatures:"Tien Anh Tran",downloadPdfUrl:"/chapter/pdf-download/69237",previewPdfUrl:"/chapter/pdf-preview/69237",authors:[{id:"222497",title:"Dr.",name:"Tien Anh",surname:"Tran",slug:"tien-anh-tran",fullName:"Tien Anh Tran"}],corrections:null},{id:"64933",title:"Ecological Predictive Maintenance of Diesel Engines",doi:"10.5772/intechopen.82599",slug:"ecological-predictive-maintenance-of-diesel-engines",totalDownloads:631,totalCrossrefCites:0,totalDimensionsCites:0,hasAltmetrics:0,abstract:"The ecological predictive maintenance (EPM) of diesel engines is a great contribution to improve the environment and to stimulate good practices with good impact in the human health. The ecology is a rapidly developing scientific discipline with great relevance to a sustainable world, whose development is not complete as a mature theory. There are, however, general principles emerging that may facilitate the development of such theory. In the meantime, these principles can serve as useful guides for EPM. According to the state of the art, it can be stated that through prediction algorithms, the equipment’s performance can be improved. To support this approach, it is necessary to implement a good condition monitoring maintenance. The result permits to maximise the time spacing between interventions and to increase the reliability levels. The condition variables of each equipment can be monitored according to their specificity, such as temperature, humidity, pollutant emissions (NOx, CO2, HC and PM), emitted noise, etc. The environment where the equipment is inserted also must be considered. The assessment of the equipment’s condition can be done by Hidden Markov Models (HMM), namely diesel engines. This chapter presents two algorithms—Viterbi and Baum-Welch algorithms—that, through the prediction of the equipment’s condition, help to increase the efficiency of the maintenance planning.",signatures:"António Simões, José Torres Farinha and Inácio Fonseca",downloadPdfUrl:"/chapter/pdf-download/64933",previewPdfUrl:"/chapter/pdf-preview/64933",authors:[{id:"254272",title:"Ph.D.",name:"António",surname:"Simões",slug:"antonio-simoes",fullName:"António Simões"}],corrections:null},{id:"63995",title:"NOx Pollutants from Diesel Vehicles and Trends in the Control Technologies",doi:"10.5772/intechopen.81112",slug:"no-sub-x-sub-pollutants-from-diesel-vehicles-and-trends-in-the-control-technologies",totalDownloads:1574,totalCrossrefCites:1,totalDimensionsCites:4,hasAltmetrics:0,abstract:"Nowadays, climate change that caused from air pollution has become a major problem on the agenda of almost all countries around the world. Compared to other air pollutants, NOx emissions have an important share in climate change, and especially diesel vehicles are one of the most important sources for the formation of NOx pollutants. This chapter focused on NOx emissions from diesel vehicles and the trends in NOx control technologies; Exhaust Gas Recirculation (EGR), Lean NOx trap (LNT) and Selective Catalytic Reduction of NOx by ammonia (NH3-SCR) and hydrocarbons (HC-SCR). The reasons of the NOx emissions, environmental effects and damages on human health, NOx emissions from diesel engines and diesel engine parameters affecting NOx emissions are handled in detail. The EGR, LNT and SCR technologies that had large reduction rates of NOx emissions and the latest developments in these systems are comprehensively explained.",signatures:"İbrahim Aslan Reşitoğlu",downloadPdfUrl:"/chapter/pdf-download/63995",previewPdfUrl:"/chapter/pdf-preview/63995",authors:[{id:"234058",title:"Dr.",name:"İbrahim Aslan",surname:"Reşitoğlu",slug:"ibrahim-aslan-resitoglu",fullName:"İbrahim Aslan Reşitoğlu"}],corrections:null},{id:"70870",title:"Identification of the Minor Chemical Elements in the Particulate Matter Exhaust Emissions From In-Use Diesel Engine Passenger Vehicles",doi:"10.5772/intechopen.90760",slug:"identification-of-the-minor-chemical-elements-in-the-particulate-matter-exhaust-emissions-from-in-us",totalDownloads:746,totalCrossrefCites:1,totalDimensionsCites:1,hasAltmetrics:1,abstract:"In this research, we investigate the minor chemical elements contained in the particulate matter (PM) exhaust emissions, generated by in-use diesel engine passenger vehicles. For this purpose, we apply a high-resolution optical emission spectroscopy technique, for precise, spectrochemical analysis of diesel particulate matter (DPM). By means of the laser-induced breakdown spectroscopy analytical method, we analyse PM from different road diesel engine vehicles. DPM were obtained from miscellaneous in-use diesel engine passenger vehicles of diverse types and models from major brand car producers in Europe. We analysed particulate matter extracted from the exhaust manifold part, from 67 different passenger vehicles, which are used in daily life environment.",signatures:"Richard Viskup, Christoph Wolf and Werner Baumgartner",downloadPdfUrl:"/chapter/pdf-download/70870",previewPdfUrl:"/chapter/pdf-preview/70870",authors:[{id:"103742",title:"Dr.",name:"Richard",surname:"Viskup",slug:"richard-viskup",fullName:"Richard Viskup"},{id:"305127",title:"M.Sc.",name:"Christoph",surname:"Wolf",slug:"christoph-wolf",fullName:"Christoph Wolf"},{id:"310228",title:"Dr.",name:"Werner",surname:"Baumgartner",slug:"werner-baumgartner",fullName:"Werner Baumgartner"}],corrections:null}],productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},subseries:null,tags:null},relatedBooks:[{type:"book",id:"5236",title:"High Energy and Short Pulse Lasers",subtitle:null,isOpenForSubmission:!1,hash:"481d4221e58d2c90fe398be93d898f43",slug:"high-energy-and-short-pulse-lasers",bookSignature:"Richard Viskup",coverURL:"https://cdn.intechopen.com/books/images_new/5236.jpg",editedByType:"Edited by",editors:[{id:"103742",title:"Dr.",name:"Richard",surname:"Viskup",slug:"richard-viskup",fullName:"Richard Viskup"}],equalEditorOne:null,equalEditorTwo:null,equalEditorThree:null,productType:{id:"1",chapterContentType:"chapter",authoredCaption:"Edited by"}},{type:"book",id:"8813",title:"Introduction to Diesel Emissions",subtitle:null,isOpenForSubmission:!1,hash:"693a8757f50c6f257cca62961cba76c2",slug:"introduction-to-diesel-emissions",bookSignature:"Richard Viskup",coverURL:"https://cdn.intechopen.com/books/images_new/8813.jpg",editedByType:"Edited by",editors:[{id:"103742",title:"Dr.",name:"Richard",surname:"Viskup",slug:"richard-viskup",fullName:"Richard 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\r\n\tWith the discovery of more unconventional heavier crude and alternative hydrocarbon sources, primary upgrading or cracking of the oil into lighter liquid fuel is critical. With increasing concern for environmental sustainability, the regulations on fuel specifications are becoming more stringent. Processing and treating crude oil into a cleaner oil with better quality is equally important. Hence, there has been a relentless and continuous effort to develop new crude upgrading and treating technologies, such as various catalytic systems for more economical and better system performance, as well as cleaner and higher-quality oil.
\r\n\tThis edited book aims to provide the reader with an overview of the state-of-the-art technologies of crude oil downstream processing which include the primary and secondary upgrading or treating processes covering desulfurization, denitrogenation, demetallation, and evidence-based developments in this area.
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Experienced users will be happy to know that many of the problems encountered a few years ago are gone. New users will never realize how difficult it once was to bring up a data acquisition system. These same technology advances have made it even more difficult than ever to select among the many options. The hardware decisions facing a user today require a great deal of study, analysis, and consideration. Every system will work, but some are better than others for each particular application.
\n\t\t\tMost data acquisition hardware is compatible with most popular industrial software, or it comes with a software package of its own. Virtually all these data acquisition devices and systems have the same basic specifications and options on their data sheets: signal conditioning, number of analog input channels, sampling rate, resolution, accuracy etc.
\n\t\t\tThe most DAS’s used in instrumentation are made it by National Instrument, including the software. These boards are plug-in types on ISA or PCI slots of the computers. In this case they will be affected by electromagnetic field. The manufacturer has to take special protection measures that increase the device costs.
\n\t\t\tTaking in consideration all this facts, we have developed a DAQB with data transfer by serial port. A set of drivers and functions specially designed to by access in LabVIEW functions palette we have made.
\n\t\t\tThe EU-funded conference on "Environment, Health, Safety: a challenge for measurements", held in Paris in June 2001, recognized the need to improve the performance of environmental measurement systems and their harmonization at EU level, to foster the dialogue between the providers of measurement methods and the users of measurement results, and to prepare the base - by establishing special communication tools – for the integration of research expertise and resources of environmental monitoring across Europe. The concept presented herein aims to respond to this actual challenge by combining the latest software trends with the newest hardware concepts in environmental monitoring, towards providing reliable measurement results and representative environmental indicators, evaluating trends and quantifying the achieved results in order to manage the potential environmental risk in compliance with European legislation and local particularities.
\n\t\t\tIn the actual development stage of the Romanian residential and industrial areas, the society demands more accurate and elaborated information in every domain. One of great interest is the air pollution filed. Over the last years, the clime changes have made the old prevision for dispersion of the air pollution around the industrial areas no longer accurate.
\n\t\t\tThe atmospheric environment needs to be examined in consideration of the following three phenomena: global warming, ozone-layer depletion, air pollution.
\n\t\t\tAmong these three, global warming is the most critical in terms of environmental conservation. Global warming is a result of greenhouse-gas emissions; therefore, to prevent it, greenhouse-gas emissions must be reduced. A major greenhouse gas is carbon dioxide (CO2). Therefore, reducing energy use, or saving energy, is the most effective way to help prevent global warming. There are some other gases that have a considerable influence on global warming. The first step to cutting the emissions of these gases as another environmental conservation measure is to monitor them in order to find a way to control them.
\n\t\t\tFor this purpose, a new concept of performing high-speed data acquisition based on remote sensors, and an accurate transmission and processing of the meteorological parameters towards obtaining useful data for the users was developed in connection with the centre services. New methods of interconnecting hardware and dedicated software support were successfully implemented in order to increase the quality and precision of measurements.
\n\t\t\tIn the same time, the Web concept itself is changing the way the measurements are made available and the results are distributed/communicated. Many different options are occurring as regards reports publishing, data sharing, and remotely controlling the applications. The LabVIEW environment was incorporated in centre concept towards creating a unique and powerful distributed application, combining together different measurement nodes and multiple users into a unique measurement controlling system, in order to integrate and revolutionize the fundamental architecture of actual PC-based measurement solutions.
\n\t\t\tThe main objective of this work is to realize an intelligent system for environmental quality control and monitoring based on specialized sensors that are connected in a unit system.
\n\t\tThe hardware of environmental quality monitoring systems (sensors, conditioning circuits, acquisition and communication) must usually be complemented with processing blocks to perform different tasks associated to one-dimensional or multi-dimensional data that flow on the system measurement channels.
\n\t\t\tThe architecture is composed as follows: the specialized sensors, detection circuit, a prototype data acquisition board, PC-host. Using all this hardware we are able to perform a study for Taguchi-type gas sensors.
\n\t\t\tIntelligent system achievement which is dedicated for particular application is not easy. It presume a selection of chemical sensors area which provide a large information quantity and complex algorithms development for signal processing.
\n\t\t\tThe developed environmental monitoring systems (EMS), that use a prototype data acquisition board, perform different tasks like: multi-sensors/multi-point measurement, continuum real-time monitoring, across limits warnings, save data etc.
\n\t\t\tAir quality parameters can be monitories, from interested areas like public places, enterprises etc. The desktop PC and LabVIEW software have the fallowing functions:
\n\t\t\t- DAQB control,
- Data processing and results display,
- Data storage and data administration
- User warning,
- Analysis and decision etc.
System architecture.
The data acquisition system is a low cost board realized around the chip LM12H458 that is an integrated DAS and offers a self-calibrating 12-bit a sign A/D converter with choice of single ended, fully differential, or mixed inputs, with on-chip differential reference, 8-input analog multiplexer, sample-and-hold, an impressive, flexible programmable logic system and a choice of speed/power combinations. The programmable logic has the circuitry to perform a number of tasks on its own, freeing the host processor for other tasks. This logic includes:
\n\t\t\t\t1. An instruction RAM that allows the DAS to function on its own (after being programmed by the host processor) with programmable acquisition time, input selection, 8-bit or 12-bit conversion mode.
2. Limit registers for comparison of the inputs against high and low limits in the “watchdog” mode.
3. A 32-word FIFO register to store conversion results until read by the host.
4. Interrupt control logic with interrupt generation for 8 different conditions.
5. A 16-bit timer register.
6. Circuitry to synchronize signal acquisition with external events.
7. A parallel microprocessor/microcontroller interface with selectable 8-bit or 16-bit data access.
The board can be used to develop both software and hardware. Since the parallel port is limited to 8-bit bidirectional data transfers, the BW pin is tied high for 8-bit access. Multiplexed address/data bus architecture was used. The circuit operates on a single +5V supply derived from the external supply using an LM7805 regulator or from USB port. This greatly attenuates noise that may be present on the computer’s power supply lines.
\n\t\t\t\tDigital and analog supply pins are connected together to the same supply voltage but they need separate, multiple bypass capacitors. Multiple capacitors on the supply pins and the reference inputs ensure a low impedance bypass path over a wide frequency range.
\n\t\t\t\tAll digital interface control signals (/RD, /WR, ALE, /INT, /CS), data lines (DB0–DB7), address lines (A0–A4) connections are made through the microcontroller pins ports.
\n\t\t\t\tAll analog signals applied to, or received by, the input multiplexer (IN0–IN7), VREF+, VREF−, VREFOUT, and the SYNC signal input/output are applied through a connector on the rear side of the board.
\n\t\t\t\tThe voltage applied to VREF− is GND and VREF+ is selected using a jumper. This jumper selects between the LM12H458 internal reference output, VREFOUT, and the voltage applied to the corresponding pin applies it to the LM12H458 VREF+ input.
\n\t\t\t\tA SYNK push button is available on the DAQB. With signal SYNC configured as an input, it is possible to synchronize the start of a conversion to an external event. This is useful in applications such as digital signal processing (DSP) where the exact timing of conversions is important.
\n\t\t\t\tBecause the LM12H458 is so versatile, working with them may appear to be an overwhelming task. However, gaining a basic understanding of the device will prove to be fairly easy and using it to be as easy as programming the host microprocessor or microcontroller (AT90S8515).
\n\t\t\t\tThe DAS is designed to be controlled by a processor, but the DAS functionality off loads most of the data acquisition burden from the processor, resulting in a great reduction of software and processor overhead. The processor downloads a set of operational instructions to the DAS RAM and registers, and then issues a start command to the DAS, which performs conversions and/or comparisons as indicated by the instructions, loading conversion results into the FIFO, while the processor is free to do other chores, or can be idled, if not needed.
\n\t\t\t\tThe DAQB architecture design.
The hardware picture.
After the DAS starts operating, the processor may respond to interrupts from the DAS, or it may interrogate the DAS at any time.
\n\t\t\t\tThe architecture design and the hardware picture are presented in Figure 2 and 3.
\n\t\t\t\tThe main features of our DAQB are: 4 full-differential channels, 12 + sign ADC resolution, 100 ksamples acquisition rate, 20 ksamples transfer rate, 1 LSB linearity, 0,5 LSB accuracy, auto-zero and full calibration procedures, ± 5V input voltage span, 30 mW power dissipation. In Table 1 we present the obtained results using the new DAQB and different apparatus.
\n\t\t\t\tNr. | \n\t\t\t\t\t\t\tGEN DC [V] | \n\t\t\t\t\t\t\tNew DAQB [V] | \n\t\t\t\t\t\t\tKEITHLEY 2000 [V] | \n\t\t\t\t\t\t\tMETERMAN 38XR [V] | \n\t\t\t\t\t\t
1 | \n\t\t\t\t\t\t\t0.010 | \n\t\t\t\t\t\t\t0.0117 | \n\t\t\t\t\t\t\t0.0116 | \n\t\t\t\t\t\t\t0.0114 | \n\t\t\t\t\t\t
2 | \n\t\t\t\t\t\t\t0.020 | \n\t\t\t\t\t\t\t0.0218 | \n\t\t\t\t\t\t\t0.0216 | \n\t\t\t\t\t\t\t0.0213 | \n\t\t\t\t\t\t
3 | \n\t\t\t\t\t\t\t0.040 | \n\t\t\t\t\t\t\t0.0425 | \n\t\t\t\t\t\t\t0.0418 | \n\t\t\t\t\t\t\t0.0414 | \n\t\t\t\t\t\t
4 | \n\t\t\t\t\t\t\t0.060 | \n\t\t\t\t\t\t\t0.0621 | \n\t\t\t\t\t\t\t0.0618 | \n\t\t\t\t\t\t\t0.0615 | \n\t\t\t\t\t\t
5 | \n\t\t\t\t\t\t\t0.080 | \n\t\t\t\t\t\t\t0.0825 | \n\t\t\t\t\t\t\t0.0819 | \n\t\t\t\t\t\t\t0.0816 | \n\t\t\t\t\t\t
6 | \n\t\t\t\t\t\t\t0.100 | \n\t\t\t\t\t\t\t0.0102 | \n\t\t\t\t\t\t\t0.1018 | \n\t\t\t\t\t\t\t0.1015 | \n\t\t\t\t\t\t
7 | \n\t\t\t\t\t\t\t0.500 | \n\t\t\t\t\t\t\t0.0505 | \n\t\t\t\t\t\t\t0.5036 | \n\t\t\t\t\t\t\t0.5034 | \n\t\t\t\t\t\t
8 | \n\t\t\t\t\t\t\t1.000 | \n\t\t\t\t\t\t\t1.0100 | \n\t\t\t\t\t\t\t1.0060 | \n\t\t\t\t\t\t\t1,0020 | \n\t\t\t\t\t\t
9 | \n\t\t\t\t\t\t\t1.500 | \n\t\t\t\t\t\t\t1.5130 | \n\t\t\t\t\t\t\t1.5070 | \n\t\t\t\t\t\t\t1,5040 | \n\t\t\t\t\t\t
10 | \n\t\t\t\t\t\t\t1.700 | \n\t\t\t\t\t\t\t1.7150 | \n\t\t\t\t\t\t\t1.7080 | \n\t\t\t\t\t\t\t1,7050 | \n\t\t\t\t\t\t
11 | \n\t\t\t\t\t\t\t2.000 | \n\t\t\t\t\t\t\t2.0180 | \n\t\t\t\t\t\t\t2.0090 | \n\t\t\t\t\t\t\t2,0060 | \n\t\t\t\t\t\t
12 | \n\t\t\t\t\t\t\t2.200 | \n\t\t\t\t\t\t\t2.2190 | \n\t\t\t\t\t\t\t2.2100 | \n\t\t\t\t\t\t\t2,2070 | \n\t\t\t\t\t\t
13 | \n\t\t\t\t\t\t\t2.400 | \n\t\t\t\t\t\t\t2.4220 | \n\t\t\t\t\t\t\t2.4110 | \n\t\t\t\t\t\t\t2,4070 | \n\t\t\t\t\t\t
14 | \n\t\t\t\t\t\t\t2.500 | \n\t\t\t\t\t\t\t2.4994 | \n\t\t\t\t\t\t\t2.5120 | \n\t\t\t\t\t\t\t2,5090 | \n\t\t\t\t\t\t
Comparative results obtained using new DAQB and different apparatus.
DAQB presented have the capability to perform tasks that diminish the host processor work and is capable to communicate with the host computer by using a set of drivers associated in LabVIEW software. The novelty of the system mostly consists in the drivers and functions associated that are gathered into a library easily accessed by LabVIEW and assure the flexibility and the portability of the system. One of the performances consist in the fact that you can plug-in the DAQB to the running host computer externally.
\n\t\t\t\tDAQB is simple, versatile, flexible, cheap, high-speed digital data acquisition system that combined with LabVIEW software, become a very useful measurement instrument.
\n\t\t\tThe sensitive elements included in analyzed environment are metal oxide semiconductor mainly composed of SnO2 and are tied to the EMS. These elements are heated at a suitable operating temperature by a built-in heater. Exposure of the sensor to a vapour produces a large change in its electrical resistance. In fresh air the sensor resistance is high. When a combustible gas such as propane, methane etc. comes in contact with the sensor surface, the sensor resistance decreases in accordance with the present gas concentration (Figure 4a). Semiconductor gas sensors based on SnO2 are widely used as safety monitors for detecting most combustible and pollution gases. However, most of the commercial gas sensors are not selective enough to detect a single chemical species in a gaseous mixture. It is desirable that a single sensor should be able to selectively detect several kinds of gases.
\n\t\t\t\tRecently, new methods have been proposed for chemical sensing that utilizes the analysis of the stochastic component of the sensor signal in Taguchi type sensors. It has been shown that even a single sensor may be sufficient for realizing a powerful electronic nose.
\n\t\t\t\tOne of the problems appearing when we use sensitive elements like metal oxide semiconductor (SnO2) is the temperature and humidity dependence of sensibility characteristic.
\n\t\t\t\tIn this case the influences of physical environmental parameters must be compensated.
\n\t\t\t\tSensitivity characteristics and detection circuit for a Figarosensor.
The signal conditioning circuits (Figure 4b) associated with Figaro gas sensors (TGS813, TGS 822), have the function to convert ΔRs variation of sensor resistance in ΔV variation of voltage.
\n\t\t\t\tThe change in the sensor resistance is obtained as the change of the output voltage across the load resistor (RL) in series whit the sensor resistance (RS). The constant 5V output of the data acquisition board is available for the heater of the sensor (VH) and for the detecting circuit (VC). The relationship between RS and VRL is expressed by the following equation.
\n\t\t\t\tThe interaction of the chemical with the surface and bulk of the sensor induces spontaneous fluctuations. Recently, new methods have been proposed for chemical sensing that utilizes the analysis of the stochastic component of the sensor signal in Taguchi type sensors. It has been shown that even a single sensor may be sufficient for realizing a powerful electronic nose. However, there are no studies of the power spectrum in different types of commercial gas sensors under different gas atmospheres. This paper studies the stochastic signal in commercial semiconductor gas sensors measured under different atmospheres.
\n\t\t\t\tA unique gas detection block is used for both architectures of the system. It contains an array of five sensors and the corresponding detection circuits (Figure 5).
\n\t\t\t\tTo detect hydrogen sulfide (H2S), ammonia (NH3) and combustible gases we use Taguchi type gas sensors produced by Figaro Co. The detection principle of TGS sensors is based on chemical adsorption and desorption of gases on the sensor surface. The sensing element is a tin dioxide (SnO2) semiconductor that is heated at a suitable operating temperature by a built-in heater. In the presence of a detectable gas, the sensor conductivity increases depending on the gas concentration in the air. A simple electrical circuit converts the change in the sensor resistance to an output voltage, which corresponds to the gas concentration.
\n\t\t\t\tTGS 813 sensor has a good sensitivity to a wide range of combustible gases for concentrations from several ppm to over 10,000 ppm. Because of poor sensor selectivity, it is used only to detect the presence of some flammable gases in the environment (methane, ethanol, isobutane, and hydrogen).
\n\t\t\t\tTGS 825 and TGS 826 sensors have good sensitivity and selectivity to H2S and NH3, respectively. The relationship of sensor resistance to gas concentration is non-linear within the practical range of gas concentration (from several ppm to 100 ppm). In the data processing part, two artificial neural networks approximate the sensitivity characteristics of these sensors for the continual measurement of H2S and NH3 concentration.
\n\t\t\t\tThe signal conditioning circuit.
Using LabVIEW software that has the capability to communicate with the serial port by Inport-Output functions, a driver for this data acquisition board was made it. We created two basic functions Write.vi (Scrie.vi) and Read.vi (Citeste.vi) which are the main functions when communicate with DAQB. The Write and Read functions are used for writing and reading into/from DAS registers.
\n\t\t\t\tConfiguration and monitoring architecture.
Based on functions Write and Read others complex functions are developed and consists in multiple writing and reading operations into and from the board registers using the basic functions. Each is responsible with specific procedures in the board operation. The functions of the virtual library in LabVIEW environment include:
\n\t\t\t\t1. One Push One Channel (acquisition with external start conversion),
2. One Push Multi Channel (acquisition with external start conversion),
3. One Scan One Channel (acquisition without external start conversion),
4. One Scan Multi Channel (acquisition without external start conversion),
5. Waveform multi channel acquisition by interruption,
6.Watchdog/One Push –one channel and acquisition
7.Watchdog/One Push –one channel without acquisition
8.Watchdog/One Push –multi channel and acquisition,
9.Watchdog/One Push –multi channel without acquisition,
10.Watchdog/One Scan –one channel and acquisition,
11.Watchdog/One Scan –one channel without acquisition,
12.Watchdog/One Scan –multi channel and acquisition),
13.Watchdog/One Scan –multi channel without acquisition,
14.Watchdog/Waveform –without acquisition for one channel,
15.Watchdog and alarm without acquisition multi channel.
For LabVIEW, the functions are constituted as sub-VIs that are included into a separate acquisition subpalette, part of the main function palette. The main function palette of the DAQB is LPT-DAS and palette includes other subpalettes:
\n\t\t\t\t1.Analog Input,
2.Calibration and Configuration,
3.Timer,
4.Signal Condit.,
5.Wachdog.
In Figure 7, subpalettes of Analog Input and Wachdog are presented.
\n\t\t\t\tThe functions palette used for communicating with the new DAQB.
The Analog Input subpalette functions contain other tow subpalette functions and simple functions like Write, Read, Start, Stop or Reset (internal sequencer).
\n\t\t\t\tWachdog subpalette contains three functions: Low Limit, High Limit and Low & High Limit.
\n\t\t\t\tNo conversion is performed in the watchdog mode, but the DAS samples the selected input(s) and compares it/them with values of the low and high limits stored in the instruction RAM. This comparison is done with a voltage comparator with one comparator input being the selected multiplexer input (pair) and the other input being the appropriate tap on the internal capacitive ladder of the converter. T his tap is selected by a programmed value in the instruction register. If the input voltage is outside of the user defined and programmed minimum/maximum limits, an interrupt can be generated to indicate a fault condition, and the host processor could then service that interrupt, taking the appropriate action.
\n\t\t\t\tThe flow diagram of the Watchdog One Channel without Acquisition.vi function will be presented. It consists in multiple writing and one final reading operation into and from the board registers. First, the reset operation has to be performed by selecting RAM section 0(RP=00) and write 0002H to CONFIGURATION register. Next, is loading instruction to INSTRUCTION RAM (set the utilized channel, the reference to ground or to other channel and the load impedance threshold. Afterwards, select the RAM section 1(RP=01) and write 0100H to CONFIGURATION register. In this moment it is possible to write the Superior Limit. Afterwards, select the RAM section 2(RP=10, write 0200H to CONFIGURATION register) and write the Inferior Limit. Start the DAS conversion by setting D0 of CONFIGURATION register high. Read the results of conversion from the Limit Status.
\n\t\t\t\tThe flow chart of the Watchdog One Channel without Acquisition.vi.
The Limit Status Register is likewise cleared whenever (Limit Status Register) is read or a device reset is issued.
\n\t\t\tThe virtual instrument is the main part of the monitoring system and, in the same time, the human interface, providing parameters control (Figure 9). The main functions of the VI are:
\n\t\t\t1. SADI programming and communication control using Nr.Scan function from the specific functions palette.
\n\t\t\t2. data processing after data reading from SADI analog input channels
\n\t\t\t3. environmental temperature calculus starting from the analog input voltage(CH2) VT.
\n\t\t\t4. sensors resistance calculus starting from CH0 and CH1 read voltages (VRL1 and VRL2):
\n\t\t\t5. Mean pollutant concentration calculus for a user presetting time interval (ppm/30min, ppm/8h, ppm/24h) for pollution level testing.
\n\t\t\t6. Pollution agent concentration limits exceeding verify for knowing the immediate effects fort health, lighting and voice user warning
\n\t\t\t7. Decrease the environmental temperature influence using a compensation subVI
\n\t\t\t8. Data base saving.
\n\t\t\tFront panel and diagram of VI environmental monitoring system.
Admitting that the temperature and humidity have a great influence to Taguchi sensor resistance we have to make a compensation of the effect very utile when the system is used for outside. Knowing the RS/R0=f(T) dependency characteristic of the sensors and the temperature from AD590 temperature sensor the VI realize a temperature compensation by parts.
\n\t\t\tAt 65% relative humidity, a characteristic linearization is made on the next intervals: -10ºC ÷ 20ºC, 20ºC ÷ 30ºC, 30ºC ÷ 40ºC. A slope determination for the three straight lines is done and for each temperature values is established the compensation factor. The main sub-VI’s are:
\n\t\t\t\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t
where,
\n\t\t\tGs=1/RS is the sensor conductivity at certain methane concentration C.
\n\t\t\tS0, b – constants determinate for two concentration (C1=1000 ppm, C2=3000 ppm) when we know the value of sensor resistance. At VI input is applied the sensor resistance (RS) after the thermal effect compensation obtaining to the output the calculated value of concentration.
\n\t\t\t\n\t\t\t\t
However, in some situation is necessary the identification (recognize) of some gases compound with different smells using complex chemical analyzes.
\n\t\t\tIf the imitation of tactile, additive and visual human senses and there implementation in tele-transmitting automat systems is well known in the literature, the smell sense was ignored. They are many applications where so called electronic nose may detect what is difficult or impossible for human or animal nose (for example, toxic waste identification, combustible mixture analyze, industrial emission monitoring, noninvasive medical analyzes, verification of food qualities, drugs detecting, mine and explosive detecting).
\n\t\t\tIntelligent system achievement which is dedicated for particular application is not easy. It presumes a selection of chemical sensors area which provide a large information quantity and complex algorithms development for signal processing.
\n\t\tFor ages, the human nose has been an important tool in assessing the quality of many products, food products being good examples. While all others parts of production processes, including these of the food industry, were getting more and more automated, there was still no “objective” means for using the “subjective” information confined in the smell of products. This changed in 1982, when Persaud and Dodd introduced the concept of an electronic nose. They proposed a system, comprising an array of essentially non-selective sensors and an appropriate pattern recognition system, often called “e-nose”.
\n\t\t\tThe task of an electronic nose is to identify an odorant sample and perhaps to estimate its concentration. The E-Nose consists of two main components: an array of gas sensors, and a pattern-recognition algorithm. Electronic odour sensing systems can include a combination of hardware components such as sensors, electronics, pumps, fans, air conditioners and flow controllers, and software for hardware observation and data processing. The gas sensors most commonly used in electronic noses are based on metal oxide semiconductor and conducting polymer techniques. Metal oxide sensors were first produced in Japan in the 1960s for use in gas alarms and depend on an alteration in conductance caused by contact with the odour and the reaction that result.
\n\t\t\tThe proposed Web E-Nose consists of three main components: an array of gas sensors, a pattern-recognition algorithm and an Ethernet module with a static IP.
\n\t\t\tWe developed a simple and original WebE-Nose prototype to test pattern recognition techniques that are necessary for building remote electronic nose systems.
\n\t\t\tGas sensors tend to have very broad selectivity, responding to many different substances. This is a disadvantage in most applications, but in the electronic nose, it is an advantage. Although every sensor in an array may respond to a given chemical, these responses will usually be different.
\n\t\t\tSensor array “sniffs” the vapors from a sample and provides a set of measurements. The pattern-recognizer compares the pattern of the measurements to stored patterns for known materials (\n\t\t\t\t\tBranzila M 2007\n\t\t\t\t).
\n\t\t\tThe implemented Web E-Nose system consists in three main components (Figure 10):
\n\t\t\ta gas sensors array,
the pattern recognition algorithm, and
Ethernet with IP static module.
Main components of the Web E-Nose.
The initial experiment was performed with a number of low selectivity gas sensors – calibrated to identify a threshold value of the most important polluting gases occurring in the atmosphere, combined with SHT11 humidity and temperature sensor, allowing immediate temperature and humidity compensation. The sensor array was also trained to recognize, by different sets of measurements, the hazard patterns for different polluting factors acting in the monitored area, as well as identify accidental patterns of polluting factors with external causes. The Ethernet module, having a static IP, give the possibility to share, over the World Wide Web, information’s about “remote polluters and potential effects, hazard level etc.” with a clear identification of the instrument and area. Finally, the result of Web E-Nose expertise may be visualized either as a code image of a given combination of volatile compounds, or may offer a review of the concentrations of individual molecule species detected in a complex environment (Figure 10).
\n\t\t\tThe response of the sensor array is numerically converted using a prototype data acquisition system SADI (integrated data acquisition system). This response is registered by microcontroller as “case pattern”, compared and classified with the ones predefined within the training library. The microcontroller, playing the role of Web E-Nose “brain”, communicates with SADI or with IP-Static module server by a serial interface.
\n\t\t\tHence, the most important function of the Web E-Nose system consists in detecting and evaluating toxic gases or mixtures at minimum threshold quantities, especially those odour-less to human senses. The information, acquired by the gas sensor arrays and rough calibrated by SHT11 temperature and humidity sensor, is subject of further processing for pat-tern recognition and transmission to the decision block by RS232 protocol to the Ethernet server.
\n\t\t\tThe Web E-Nose system has five sequential stages: pre-processing, feature extraction, classification, decision making and decision transmission to the network. The decision making, based on pattern recognition, is assisted by a neural network with both training and extraction functions.
\n\t\t\tIt goes without saying that the Web E-Nose system was not projected to substitute human capability of detecting hazardous situations by “smelling”. In addition, the exquisite sensitivity of the dog\'s nose for sniffing out odours associated to drugs or other hazardous vapours has not yet been matched by currently designed E-nose.
\n\t\t\tBut the system is well suited for repetitive and accurate measurements, and provided not to be affected by saturation, a common disadvantage of natural smelling senses.
\n\t\t\tOur human nose is elegant, sensitive, and self-repairing, but the Web-E-Nose sensors do not fatigue or get the “flu”. Further, the Web-E-Nose can be sent to detect toxic and otherwise hazardous situations that humans may wish to avoid. Sensors can detect toxic CO, which is odorless to humans. And humans are not well suited for repetitive or boring tasks that are better left to machines. No wonder the E-Nose is sometimes referred to as a "sniffer".
\n\t\t\tHowever, the human nose is still preferred for many situations like the selection of a fine wine or to determine the off-odor of recycled plastics. In addition, the exquisite sensitivity of the dog\'s nose for sniffing out drugs or contraband at an airport is legendary already. These skills have not yet been matched by any currently designed E-Nose.
\n\t\t\tWeb E-Nose communication architecture.
The Web concept itself is changing the way the measurements are made available and the results are distributed/communicated. Many different options are occurring as regards reports publishing, data sharing, and remotely controlling the applications.
\n\t\t\tThe low-cost availability of new communication tools based on Internet is opening more and more horizons to remote teaching. Interactive on-line tutorials based on World Wide Web (WWW) sites now can be followed directly on the web site. The hardware of monitoring systems (sensors, conditioning circuits, acquisition and communication) must usually be complemented with processing blocks to perform different tasks associated to one-dimensional or multi-dimensional data that flow on the system measurement channels.
\n\t\t\tThe recent wide diffusion of (i) easy-to-use software tools for the implementation of Graphical User Interfaces (GUIs); and (ii) communication-oriented instrumentation, often provided with Ethernet interface, in addition to the more traditional GPIB and RS-232 ones, can be particularly exploited in the field of measurement teaching. It is well known, in fact, that for a better understanding of the teaching issues in such a field, the students have to practice with real instrumentation. The computer-based simulations are often inadequate to assure a good experience in that direction. The tools mentioned above give the possibility of accessing real measurement instrumentation from a remote location, such as the students’ homes (Arpaia P& Daponte P 1996, 1997, 2000). Moreover, it could be possible to repeat the same experience many times in order to make all students able to operate the measuring instrumentation without devoting expert technicians to such activity for many days [11-15].
\n\t\t\tIn measurement teaching, the great increase of students on the one hand, and the reduced number of technicians on the other, greatly requires the possibility of accessing real measurement instrumentation for remote experiments (Donciu C, 2001), (Donciu C & Rapuano C, 2002).
\n\t\t\tIn electrical and electronic measurement courses, particularly, these problems become more severe as consequences of the more sophisticated and expensive apparatus now avail-able which makes it difficult to keep the technical staff up-to-date, and the necessity for repeating the same experience many times in order to make all students able to operate the measuring instrumentation.
\n\t\t\tThere are two basic options when it comes to atmospheric monitoring: use of portable gas detectors or use of fixed detection systems. Portable monitors are battery-operated, transportable devices worn by the person using it and generally can detect only few gases at a time. There are places where many potentially hazardous gases can be permanently present: refineries, chemical plants, gas production plants, laboratories, mines, a.s.o. In these cases, a fixed system placed in the area where leaks of potentially dangerous gases likely to occur may provide general continuous monitoring.
\n\t\t\tThe objective of our research is the development of compact fixed systems for real-time monitoring of the air contaminants, suited for gas leak detection, environmental control, worker protection or other industrial applications. In the first stage, we have designed a sys-tem capable to detect only several combustible gases, using a Web E-Nose. The monitoring of more air pollutants increases the system complexity.
\n\t\t\tOur system performs the following main functions: detection of combustible gases (methane, ethanol, isobutane, hydrogen) and concentration measurement of toxic gases (carbon monoxide, hydrogen sulfide, ammonia). The system provides an alarm when the concentration of detected gases in the air reaches a dangerous level: % LEL (Lower Explosive Limit) – for combustible gases, TLV/TWA (Threshold Limit Value/Time Weighted Average), IDHL (Immediately Dangerous to Life or Health) – for toxic gases.
\n\t\t\tIt can be very useful in the new society information to create a Virtual Laboratory for a remote teaching [3-4].
\n\t\t\tAn adaptive architecture based on web server application is proposed, in order to increase the performance of the server that hosts a dedicated Web site, and customize the Web site in a manner that emphasizes the interests of the clients. The most virtual laboratories normally provide access either to one remote application, or accept only one user at a time. The system presented below provide a multitask connection, with possible variants for remote education. In this way, two parts compose the architecture of the system:
\n\t\t\tclient user that uses a client computer and
measurement provider who disposes the server with the web site of the virtual laboratory.
The users will be able to perform the lab work, controlling the applications and accessing the virtual library. Number of users connected in the same time is unlimited.
\n\t\t\tThe LabVIEW environment was incorporated in centre concept towards creating a unique and powerful distributed application, combining together different measurement nodes and multiple users into a unique measurement controlling system, in order to integrate and revolutionize the fundamental architecture of actual PC-based measurement solutions. All communication software is designed under LabVIEW graphical programming language.
\n\t\t\tIn the Figure 12 is presented the main web page of application
\n\t\t\tThe main web page of Virtual Laboratory.
The Grid technologies are introduced to build e-Learning environments for engineering education. Service-oriented Grids open new fields of applications, the Learning Grids. The learning services concept based on a learning model and their deployment through Grid technologies are excellent means to integrate virtual laboratories into e-Learning environments for engineering education. Examples from a virtual laboratory demonstrate the advantages of a Grid.
\n\t\t\tRemote or virtual laboratories with real or simulated experiments are becoming accepted in the engineering community for providing distance education and for augmenting traditional laboratories. Students have to modify instruments for a better understanding of the principle on which the plant operates. They even have to set their own conditions. From a pedagogical point of view, in this kind of environments the student has an active and central role in the learning process. Learning activities are inherently aimed at aiding the construction of knowledge and skills in the student, rather than the memorization of information. In keeping the student at the centre of the learning process, personalization and individualization become relevant aspects to be supported by technologies through the creation of the right context. The students can learn through direct experiences. So, the question remains – how do we provide better means for e-Learning environments combined with virtual laboratories while maintaining or improving the quality of learning by new information and communication technologies. A Learning Grid can contribute to the achievement of these objectives through the definition of the learning services concept and their deployment through Grid technologies.
\n\t\t\tGrids yield significant benefits to applications. A Grid is considered as a collection of clustered computational machines, the nodes. In order to have a powerful supercomputer by a Grid the computational problem has to be split into slices and assigned to these nodes. Each node processes its slice individually and after the completion of its slice the results are put back together. Grid nodes do not need to be placed in one geographic location; moreover, machines collaborating in the Grid may have different architectures and operating systems. It is obvious that these nodes need to communicate with each other based on some standards. Therefore a vital topic of security is involved for the interchange of data between nodes. Depending on the application the data should be kept confidential and protected from undesired external changes. Also other issues must be addressed, e.g. redundancy of nodes, quality of service and scalability.
\n\t\t\tThe Grid is applicable only for tasks that can be easily split into smaller slices and that do not require the characteristics of a real-time challenge. In order to reduce the complexity of a Grid, a special layer is introduced that is for gluing the nodes on a logical level. This layer of software sandwiched between the operating system and the applications is commonly called middleware. During recent years a new approach for building Grids has emerged. Instead of perceiving the Grid nodes only as computational elements of an infrastructure they became providers of services. This shift, from strict computational capabilities to service suppliers, opens new fields of applications for Grids. The nodes, instead of only delivering their computational and storage capacity, are now regarded as providers of particular services. They may be parts of some code existing in multiple instances allowing the parallelization of the execution of an application. This new Grid philosophy allows perceiving it in analogy to the commonly known concept of power grids, where the consumer is not aware where and how the power is exactly produced. The consumer only receives the final product with a defined quality.
\n\t\t\t\n\t\t\t\tFigure 13 presents basic interactions between elements of a service-oriented Grid. Services published into a Grid Registry are queried and when discovered then instantiated depending on the user request. Mainly for sake of efficiency the client’s communication with the service is direct but may also be virtualized.
\n\t\t\tStructure of a service-oriented Grid environment.
The main functionalities delivered by the middleware of a service-oriented Grid are:
\n\t\t\t1. Location – allows the determination, whether the required service exists and at which locations it is accessible
2. Instantiation – allows the instantiation of the service on that host, which matches the capabilities required for the service running with a given quality of service.
3. Orchestration – allows the dynamical composition of more complex services.
From real world instruments to Grid structure, through Virtual Laboratory.
Learning Grids contribute to the achievement of the objectives given in the introductory chapter to this article through the definition of the learning services concept and their deployment through Grid technologies. Learning services will be consumed in dynamic virtual communities based on communications and collaborations where learners, through direct experiences, create and share their knowledge in a contextualized and personalized way.
\n\t\t\tThis way of learning using grid resources can become now more open to learners in the engineering domain. The application of Grid technologies in education is of course a much wider topic than presented in this article and by the practical example of a virtual control laboratory. Nonetheless the most important aspects of utilizing service-oriented Grids in distance learning for control education are presented.
\n\t\tThe presented system constitutes a versatile, flexible, cheap, high-speed digital data acquisition system that combined with LabView software give the possibility to easily monitoring the environmental parameters. They are many applications where the system can be used like: toxic waste identification, combustible mixture analyze, industrial emission monitoring, non-invasive medical analyzes, verification of food qualities, drugs detecting, mine and explosive detecting.
\n\t\t\tThis system can be adapted for an intelligent electronic nose with data transfer directly through the internet. I named Web E-Nose.
\n\t\t\tThe Internet continues to become more integrated into our daily lives. This is particularly true for scientists and engineers, because designers of development systems view the Internet as a cost-effective worldwide standard for distributing data.
\n\t\t\tThe paper presents the architecture of a versatile, flexible, cost efficient, high-speed measurement centre, based on remote instrumentation, and having as final purposes the monitoring of the air quality and the advertising of the air pollution. On the other hand the E-Medicine becomes a very interesting domain for physicians and bioengineers. That for the purposed system can be very useful tool for them.
\n\t\t\tIn many locations a basic infrastructure to evaluate the E-Medicine already exists, but a unitary concept of an E-Medicine centre can be used to deliver services of comparable or higher quality, at a clear lower cost and a higher speed and reliability.
\n\t\t\tThe Web-E-Nose system was tested, and provided to be well suited for repetitive and accurate measurements, without being affected by saturation. But the successful implementation of such Web E-Nose concepts for air pollution evaluation at larger scales will require a careful examination of all costs, either direct or indirect, and should demonstrate its societal benefit over time.
\n\t\t\tThe remote and distributed measurement system developed as environmental centre may be also particularized as virtual laboratory for on-line environmental monitoring, helping the formation of well trained specialists in the domain.
\n\t\t\tThe Web E-Nose is a tool that may be used for safety, quality, or process monitoring, accomplishing in a few minutes procedures that may presently require days to complete.
\n\t\t\tThe system performs good and fast measurement, processing and transmission of the odors. It is very useful in the new society information to create a Virtual Laboratory for a remote teaching or to get information about gas mixtures or odours from a remote site.
\n\t\t\tThe application of Grid technologies in education is of course a much wider topic than presented in this article and by the practical example of a virtual control laboratory. Nonetheless the most important aspects of utilizing service-oriented Grids in distance learning for control education are presented.
\n\t\tDental implant service is a life-changing treatment modality for many patients. Giving our patients a fixed restoration is a very rewarding procedure, especially if the patients have difficulties: gage reflex, bulky prostheses, lack in retention, stability, or support. Unfortunately, this is not applicable for all patients, especially patients who cannot afford multiple implants or bone grafting. By considering the strategic implants under the existing removable partial denture (RPD), we make implant treatment simple and affordable for more patients.
The removable partial denture (RPD) is the dental prostheses that the patient, who suffers the absence of some but not all the natural teeth, can readily insert and remove from his/her mouth. The prostheses restore the missing teeth as well as the gingiva and the missing bone if needed. Removable partial dentures (RPDs) are indicated for patients with a long edentulous span, too long for a fixed prosthesis. The RPD is indicated for a patient with no posterior abutment to support a fixed prosthesis, and the cantilever bridge is contraindicated. Also, it is preferred if excessive alveolar bone loss is encountered, especially in the esthetic zone. Those patients who are not indicated for bone grafting or unable to afford the costly treatment are good candidates for the removable denture (RD). The acrylic flang is a good approach to compensate for the bone and soft tissue deficiency within a short fabrication time and a less aggressive approach. Moreover, this treatment option allows the patient to remove his prostheses for easier intraoral access, subsequently, better oral hygiene. The RD enables the dentist to repair or adjust the prostheses easily.
On the other hand, RD is less secure with limited retention and stability than fixed prostheses. RD metal clasp may compromise the final esthetic result. It may act as a gum stripper and accelerate alveolar bone resorption. These drawbacks in the RD can be managed by upgrading the RD using strategic implants, which are “the implants that change the prosthetic support type to a more favorable configuration” [1].
In this chapter the folllowing points is going to be discussed:
Classification as a systematic approach for communication and planning:
Kennedy classification system
Steffel classification and modified Steffel classification
Implant-Corrected Kennedy (ICK) Classification System for Partially Edentulous Arches
Strategic mini dental implants (MDI) and standard dental implant (SDI) under existing RPD, how many implant?
The abutment prosthetic value
Immediate and delayed restoration/loading, what is the difference?
Why strategic implant?
Mini-implant-assisted removable partial denture
Conclusion
A classification is a systematic approach in which the items or units are categories in groups or subgroups according to specific criteria. This approach facilitates the discussion regarding the most suitable treatment options, eases the communication between the dentist and the technician. The classification also allows for visualization and differentiation between the RPD support types: tooth-supported, tooth tissue-supported, tissue-supported, implant-supported, implant tissue-supported, and implant tooth-supported.
In 1925 Dr. Edward Kennedy introduced his approach of categorizing partially edentulous arches into four classes. He categorized the partially edentulous arches in a way that considered the edentulous area position in the arch and if it was surrounded with teeth or not. This approach was beneficial in visualizing the cases and reaching the decisions regarding the RPD designs.
The following is the Kennedy classification:
Class I: Edentulous free-end areas located on both sides (bilateral), posterior to the remaining teeth (Figure 1).
Class I maxillary arch.
Class II: Edentulous free-end area located on one side (unilateral), posterior to the remaining teeth (Figure 2).
Class II maxillary arch.
Class III: Edentulous bounded area with natural teeth remaining both anterior and posterior to it (Figure 3). The area is located on one side (unilateral).
Class III maxillary arch.
Class IV: Edentulous bounded area with natural teeth remaining posterior to it. The area is located anteriorly and crossing the mid-line (Figure 4).
Class IV maxillary arch.
In 1965 Applegate’s added eight rules to the classification. The rules can be summarized by the following: The categorization (classification) is always determined by the most posterior edentulous region (or regions). Any additional edentulous area (other than those that define the categorization) is considered a modification (Figures 6 and 7). If the teeth posterior to the edentulous area are not used to support the RPD, the edentulous area is classified as a free end (Figures 5 and 7), and vice versa (Figures 6 and 7). If the posterior free end edentulous region is not going to receive artificial teeth, it will not be considered in the classification (Figures 6–8), and vice versa. Putting the design and the structure of the RPD into consideration is a cornerstone in giving the correct RPD classification. Subsequently, the classification will be the start point making the best clinical decision regarding the number and the position of strategic implants under the RPD.
No rest is going to be costructed on # 38 or 37 → the arch has two free end areas → Class I mandibular arch.
Direct retainer is going to be constructed on 37. No artificial teeth is going to replace 46, 47 or 48 → no free end → Class III mod 1 mandibular arch.
No artificial teeth is going to replace, 48. Direct retainer is going to be constructed on 37 but not on 47 → one free end → Class II mod 3 mandibular arch.
No artificial teeth is going to replace, 38, 37, 36, 47 or 48. Class IV mandibular arch.
In 1962 Steffel described six support possibilities that can be encountered in RPD [2]. He labeled the classification categories from A to F based on the fulcrum, and the number and distribution of the abutments, Figure 9. The fulcrum line is a hypothetical line formed between abutments, teeth or implants. The RPD may rotate somewhat around the fulcrum during function.
Steffel classification.
In this chapter, we suggest a modification to this classification to simplify the communication and decision-making regarding the strategic implant under the existing RPD. In the modification, B, C, and D will be labeled together.
The following is the
Punctual-support, only one abutment.
Linear-support, two abutments; separated with edentulous area or at least one tooth.
Triangular-support, three well-distributed abutments; separated with edentulous area or at least one tooth. One of the abutments should be on the opposite quadrant.
Quadrangular-support, two well-distributed abutments on every quadrant.
Providing the patient with a stable prosthesis is a crucial target for the dentist. However, the RPD is not rigidly attached to the intraoral hard (teeth) and soft (mucosa) tissues, which have different levels of compressibility and mobility. Subsequently, the chewing and occlusal forces may generate different levels of tissue stress and prosthesis mobility. Both (stress and mobility) should be within the physiological level and cause no harm or trauma. Achieving this critical goal depends on the clinician’s understanding of the biomechanics and the different design solutions. The RPD design should consider the unique nature of each clinical case and counter the expected RPD movement in response to loading. The design also should minimize the potentially destructive forces that may affect the supporting tissues; teeth, mucosa, and bone. That can be achieved by avoiding a long lever system, good selection for the RPD supporting elements, and wide symmetrical distribution of the functional forces [3, 4]. Many of the previous points (if not all) can be achieved (fully or partially) by delivering an RPD with quadrangular-support type.
According to the modified Steffel classification, there are four types of prosthetic support: punctual, linear, triangular, and quadrangular. The RPD support improves gradually as the classification change from I to IV. Classification IV provides the best support to the RPD with the highest resistance of rotation. The strategic implant aims to change the prosthetic support type to a more favorable configuration.
One of the simple classification systems for RPD supported with implants or implants and natural teeth is Implant-Corrected Kennedy (ICK) classification system for partially edentulous arches by Al-Johany et al. [5]. The ICK is based on the Kennedy classification system and the Applegate eight rules (Applegate–Kennedy system) [6]. According to the ICK classification system coding guidelines, the Kennedy classification comes first, followed by the number of modification spaces (Applegate rules). Finally, round brackets enclose # followed by the implant’s or implants’ position will be added, Figures 10–18.
ICK I (# 25).
ICK II mod 2 (# 33, 36). Direct retainer is going to be constructed on 28.
ICK II mod 3 (# 13, 23). Direct retainer is going to be constructed on 28.
ICK II mod 1 (# 16, 13, 23).
ICK II (# 35, 33, 43).
ICK III mod 3 (# 41).
ICK III mod 1 (# 34, 42).
ICK III mod 1 (# 13, 23).
ICK IV (# 33, 43). Direct retainers are going to be constructed on 36 and 47. No artificial teeth are going to replace 37 or 38.
Meeting our patient’s expectations is a priority. That cannot be reached if the dentist did not provide the patient with a full straightforward clarification for the treatment plan. The clarification should cover the advantages, disadvantages, risks, time, cost, and alternatives. The explanation should be done in a way that helps both the patient first and the dentist second to reach the decision that best matches the patients’ needs, health status, and financial ability, as well as respect the patient’s chief complaint and consideration. Generally speaking, teeth-implant- or implant-supported removable dentures reduce (and in many cases eliminate) traditional denture problems [1, 7, 8, 9]. It helps the dentist widen his options to meet the patient’s needs and expectations by inserting one or few implants in strategic positions, but how many implants?
The needed number of mini dental implants (MDIs) or standard dental implants (SDIs) under existing RPD is a multifactorial process (see paragraph 2.5) and taken on the quadrant level. To give the patient an RPD with acceptable retention, stability, and support, the abutments should be well distributed. Two abutments on every quadrant in symmetrical position as possible are needed. On every quadrant, the sum of the abutments prosthetic value should be ≥2, Table 1 and Figure 19.
(A1 upper jaw and A2 lower jaw to G1 upper jaw): The recommended number of strategic standard implants (SDIs) or mini dental implants (MDIs) under existing RPD.
The abutments prosthetic value | ||
---|---|---|
Teeth | Upper or lower incisor or lateral incisor | 0–0.5* |
Upper or lower canine | 1.3** | |
Upper or lower premolar or molar | 1*** | |
MDI | Upper MDI | 0.5–0.7**** |
lower MDI | 1 | |
SDI | Upper Standard Implant | 1 |
Lower Standard Implant | 1 |
The prosthetic value of the available teeth and the planned MDIs and SDIs. The recommendations are on the quadrant level.
The numbers represent the prosthetic value if abutment rest is planned; if not, the value will be 0.
If the four natural anterior abutment teeth are missing (11, 12, 13, 14), strategic implant/s is recommended even if all posterior teeth are available, and vice versa.
If there is no space ( edentulous area or at least one natural tooth) between the abutment teeth, the prosthetic value will decrease to 0.5 for each abutment.
Bone quality impacts the MDI prosthetic value.
For partially edentulous patients, the abutments can be implants or natural teeth and should be well-distributed with a sum of the prosthetic value ≥2 on quadrant level.
In the course of formulating the prosthodontic plan, not all teeth or abutments have the same prosthetic value. The prosthetic value stands for the importance of the tooth or implant from a specific prosthodontic point of view. The last first molar (#36) in Figure 20 has a very high prosthetic value than the lateral incisor #32. Extracting #36 shifts the treatment modality (if an implant is not feasible) from fixed partial denture to removable partial denture. Suppose the dentist changes his prosthodontic point of view by selecting RPD as a treatment modality. In that case, the prosthetic value of #36 will be reduced a little for this specific treatment modality. However, the prosthetic value for the same tooth (#36, Figure 20) and the same treatment modality (RPD) will be very high if the patient has a knife-edge thin, sensitive mucosa. Usually, this type of patient can tolerate tooth-tooth-supported RPD better than tooth tissue-supported RPD. Therefore, it can be concluded that:
The #36 has a very high prosthetic value because the extracting change the treatment modality (if implant is not feasible) from fixed partial denture to removable partial denture.
The hidden #23 MDI under the saddle (Figure 21) has a very high esthetic value as it helps the dentist avoid metal clasp in the esthetic zone. In some cases, strategic implants enable the dentist to reduce or remove the flange to achieve a better esthetic result by reducing lip protrusion. In other cases, it gives the dentist the ability to minimize the RPD size (palate, Figure 24) and increase patient acceptance.
The SDI #23 and MDI #33 have very high esthetic value as they help the dentist avoiding anterior metal clasps. #27 and MDI 35 have relatively high prosthetic value as they shift the RPD from tooth tissue supported to more implant tooth-supprted or implat implant-supported RPD.
The prosthetic value (importance) for each abutment is estimated according to Table 1 and mainly the following points: [11, 12, 17, 18].
Periodontal status, mobility, and bone level around the abutment.
Crown-root ratio.
Tooth vitality, size of the defect (caries), size, and type of the restoration.
The shape and number of the abutment roots.
Occlusion, parafunctional activity and opposite jaw status: natural teeth, implant, fixed partial denture, complete denture, or partial denture.
In 1981 Albrektsson et al. suggested a protocol in which the implants are left to heal in situ for at least 3 to 4 months without loading [19]. He considered the non-loading phase a crucial period to achieve successful osseointegration and avoid fibrous tissue formation between the implant surface and the bone. On the other hand, many clinical studies proved that immediate restoration, immediate loading, or early loading are acceptable treatment modalities [20, 21]. These studies were in response to the social and psychological needs of many patients. The immediate or early treatment modalities aim to reduce the overall recovery time between the surgical intervention and the insertion of the final restoration. These approaches are known as immediate restoration protocol, immediate loading protocol, and early loading protocol.
Patients typically are uncomfortable and, in many cases, refuse to stay without their RPD for a long time, especially if it restores a lot of missing teeth or teeth in the esthetic zone. The immediate protocols can reduce the patient concerns related to the final restoration by reducing the waiting period. In some cases, a temporary restoration is immediately delivered to give the patient a hint on the form, size, and position (in some cases, the shade) of the final restoration. Moreover, the second surgical intervention can be averted through immediate protocols. To achieve a good success rate in this treatment modality, a good understanding of the topic, terminology, limitation, and biology is essential. These topics will be discussed in other chapters, but it is crucial to clarify a few terms.
The loading can be classified into four categories:
Conventional loading: The implants are left without loading for around two to three months.
Delayed loading: If the loading on the implant is applied after the conventional loading time, it is classified as delayed. That can be indicated if the tissue needs more healing time, such as external sinus lift with bone grafting. In such cases, the final restoration and implant loading may be applied after six to nine months.
Early loading: The implant is loaded by placing dental restoration in contact with opposing dentition at any time after one week but within two months after implant insertion.
Immediate loading: The dental restoration is inserted intraorally and placed in contact with opposing dentition within one week after the surgical intervention.
The timing of dental restoration can also be categorized to:
Conventional restoration in which the implant is left without temporary or final restoration for around two to three months.
Immediate restoration: The temporary or final restoration is placed within one week after surgical intervention.
Early restoration: The temporary or final restoration is placed any time after one week but within two months after implant insertion.
Delayed restoration: If the dental restoration is placed intraorally after the conventional loading time, the restoration is classified as delayed restoration.
According to the previous classifications, the dentist has different types of intervention. For example, he can go for immediate restoration with conventional loading or implement early restoration with delayed loading.
In the case of the strategic implant under existing RPD, there are seven scenarios: immediate restoration with one of the four loading types, or early restoration with early, conventional, or delayed loading. The decision regarding the best approach is multifactorial: age, esthetic expectations, oral hygiene level, bone quality and quantity, and treatment expenses. According to the 2018 census supported by the International Team for Implantology (ITI), the most critical factors that may impact the loading protocol selection are patient-related factors, especially patient’s general health, implant primary stability (ISQ), bone grafting, the size and shape of the implant, and the doctor skills and experience [22]. Moreover, the ITI tried to unify the two classifications (loading and restoration timing) to make it less complicated for the clinician and easier for the researchers to perform clinical studies and compare their results. They described four protocols:
Immediate loading: Within one week after implant placement, dental implants are linked to a prosthesis in occlusion with the opposing arch.
Immediate restoration: Within one week after implant placement, dental implants are linked to the dental restoration and are kept out of occlusion.
Early loading: Between one week and two months following implant placement, dental implants are linked to the prosthesis.
Conventional loading: dental implants are linked to the prosthesis after two months of implantation.
Improving dental treatment output by using implants to enhance the functional performance of the complete denture is a well-known approach in prosthodontics. The McGill Consensus Statement stated that the first option in treating the lower jaw edentulous patient should be two implants retained overdenture and not lower jaw conventional complete denture (CD) [23]. Overwhelming scientific evidence supports the statement [23]. The evidence emphasized the superiority of two implants retained overdenture treatment modality on the conventional CD in many aspects, such as patients’ chewing efficiency, positive modification in patients’ diet, patients’ satisfaction with the CD stability, retention, and comfort as well as quality of life [23]. Although a lot of scientific evidence highlighted the positive impact of inserting implants under existing RPD, no similar Consensus Statement is available regarding implant-retained or implant-assisted removable partial denture [24, 25, 26].
Not all patients are suitable for implant-supported fixed dental prostheses. For example, many patients are unwilling to have an extra surgical intervention (bone grafting, sinus lifting, bone splitting, or expansion). Other patients are not suitable for such intervention because they are medically compromised or do not have adequate financial flexibility. As an alternative to inserting multiple implants, the dentist can improve the quality of the prosthodontic treatment by changing the support type of the RPD to the quadrangular-support type. The improvement can be achieved by inserting one/two standard implants or one/two/three mini-implants per quadrant to reach a symmetrical quadrangular-support type. The prostheses will be tooth implant-supported RPD instead of tooth tissue-supported RPD. This prosthodontic approach is affordable to many patients.
The strategic implant is “the implant that can change the prosthetic support type to a more favorable configuration” [1]. It is a reliable way of treatment with an implant survival rate of 91.7–100% [4]. Also, it can support both the RPD and the other abutments effectively. In two clinical studies with 2 and 3 years follow-up, the survival rate of the natural teeth abutments was 100% [9, 24].
Moreover, it can improve the survival rate of the RPD. The 10-year survival rate of RPDs; clasp-retained removable partial dentures, conical crown-retained dentures, or a combination of conical crown and clasp-retained dentures is 71.3% [27]. On the other hand, clinical studies with observation periods between 1 and 12.2 years reported survival rates of 90–100% for the implant-assisted removable partial denture prostheses [7, 28, 29, 30, 31]. This remarked difference in the survival rate plays an essential role in formulating the prosthodontic plan.
Many clinical studies have shown that implant placement in strategic locations under an existing RPD can enhance chewing efficiency, dental health-related quality of life, and patient satisfaction with speaking and eating, as well as RPD retention, stability, and support [1, 8, 32]. Above that, it gives the dentist the ability to reduce the tissue coverage and reduce the size of the RPD, which can positively impact the patient’s acceptance of the RPD, especially if he suffers hyperactive gag reflex, Figure 24. Also, it can improve the final esthetic result by avoiding the traditional metal clasp, Figures 19 and 22.
Upgrading the existing clasp retained lower RPD by inserting strategic mini-implants, immediate restoration with immediate loading/soft material. A- Intraoral image with lower RPD before implantation. B- Partial edentulous lower jaw before implantation. C- Tissue surface of the RPD before implantation. D- Four strategic mini-implants in the interforaminal region, tooth 32 was extracted. E- Tissue surface of the RPD after implantation, soft relining in the areas opposing the implants’ head. F- Tissue surface of the RPD after 4 months, the matrix pick-up (housings). G- Intraoral image with lower RPD after the housing, clasps in esthetic zone were removed.
Unfortunately, inserting a standard implant under the existing RPD is not always feasible. The patient may have a very narrow bone that prevents inserting a standard implant without bone grafting. A procedure that is not suitable or acceptable by some patients. In this case, mini-implants can be considered a good alternative, Figures 22 and 25 [1, 8, 16].
In 1976, the U.S. Food and Drug Administration (FDA) approved the 3 mm root-form dental implant. With time, dental implants proved to be a predictable and reliable prosthodontic treatment modality with a high success rate [33, 34, 35]. After 21 years, the approval was cleared for implants less than 3 mm. The approval widens the spectrum of the patients treated with dental implants, particularly the cases with reduced bone width.
In literature, there is no standardization regarding the terminology of dental implant diameter [36]. For example, some authors considered the implants with diameters from 1.8 to 2.9 mm as small implants; others call them mini-implants [37]. Some authors defined the mini-implant as the implant with 2.2 mm [38]. Al-Johany et al. proposed a classification scheme and used four terms: Extra-narrow <3.0 mm, Narrow ≥3.0 mm to <3.75 mm, Standard 3.75 mm to <5 mm, and Wide ≥5 mm [36]. In this text, we will follow the lead of Resnik et al. and Schiegnitz et al. by considering the mini-implant as the implant with a diameter < 3.0 and the narrow-diameter implant as the implant with a diameter ≤ 3.5 [25, 37]. This implant type is mainly used in heavily atrophic jaws but with sufficient bone height. The mini-implant gives the dentist the ability to avoid bone augmentation procedure, which is considered a time and cost-consuming surgical intervention. Avoiding additional surgical procedures can reduce morbidity and possible complications such as nerve trauma, hemorrhage, postoperative pain, or infection [25]. The infection may lead to the failure of bone grafting [25]. Above that, it is less invasive than the standard implant as it requires a smaller implant bed and no flap in a considerable number of cases [26]. Therefore, it is more appropriate for the compromised or elderly patients. Moreover, it is cost-effective and affordable. On the other hand, the small diameter of the implant may create a shear load to the crestal bone. That may increase the risk of bone resorption [37, 39]. Narrow -implant has been linked to biomechanical risk factors as implant fatigue or fracture, particularly when used in the canine area where high occlusal loads are applied or in parafunctional habits patients [40].
A systematic review and meta-analysis reported that mini-implants (diameter < 3.0 mm) performed substantially worse than standard diameter implants with survival rates of 94.7 ± 5% [25]. However, narrow implants with a diameter (3–3.5 mm) have a better survival rate of 97.7 ± 2.3% [25]. Therefore, some researchers believe the best approach for a thin bone is bone augmentation [37]. If this is not feasible, narrow implant, osteoplasty and standard implant, or one-piece mini-implant with ball attachment and removable denture can be considered, Figure 23.
Narrow bone can be treated with bone grafting. Unfortunately, this is not always feasible. A- Biomechanically, the narrow implant is not always the best approach, see paragraph 5. B- Osteoplasty is used to insert a wider implant by increasing the bone width, which will impact the crown-implant ratio negatively and may place the implant near vital anatomical structure. C- One-piece mini-implant with ball attachment and preferable crown-implant ratio can be used to stabilize a complete removable denture or partial removable denture.
The small diameter implant is used to replace missing individual teeth in the anterior region, lower and upper jaw [41, 42]. Mini-implant is used as an orthodontic implant or transitional or provisional implant to support interim prostheses during the healing period after extensive implantations or augmentations and bone grafting [43]. The one-piece mini-implant with ball attachment is used as assisting / anchoring element under the removable denture [1]. Strategic min-implant under existing RPD and CD proved to be a reliable and straightforward approach [1, 8, 44]. New studies reported that the one-piece mini-implant with ball attachment has a significant advantage on the final prosthodontic treatment [1, 8].
The one-piece implant mimics nature by having a solid unibody structure with no microgaps between the implant and the abutment. As a result, the possible biological complication (bone resorption) and structural flaw are reduced. Also, the flap or flapless single-stage surgery allows the dentist to implement immediate loading or immediate restoration [42]. Moreover, delayed loading is possible by preparing a recess against the mini-implant in the RPD’s tissue surface. The treatment protocol can be conventional or delayed loading. However, the recess (cavity) distorts the fit of the RPD’s, Figure 24.
Upgrading the existing double crown retained upper RPD by inserting strategic mini-implants, immediate restoration, and delayed loading. A- Partial edentulous upper jaw before implantation. B- Tissue surface of the RPD before implantation. C- Five strategic mini-implants. D- Tissue surface of the RPD after implantation, recesses (empty notches) against the mini-implants. E- Tissue surface of the RPD after 4 months, the matrix pick-up (housings). The palate coverage was reduced. F- Intraoral image with the RPD after the housing.
On the other hand, if the mini-implants are inserted in a healthy, not compromised patent with insertion torque ≥35 Ncm, immediate loading can be considered. The immediate restoration with immediate loading can be implemented through one of two forms:
immediate loading using soft relining material, Figure 22.
immediate loading using the matrix pick-up (housings), Figure 25.
Upgrading the existing double crown retained lower RPD by inserting strategic mini-implants, immediate restoration and immediate loading. A- Partial edentulous lower jaw before implantation. B- Tissue surface of the RPD before implantation. C- Two strategic mini-implants. D- Tissue surface of the RPD after implantation, the matrix pick-up (housings) inserted in the same implantation session. E- Intraoral image with the RPD in place after implantation.
After implantation, soft relining material can restore the fit of the RPD, ease tissue pressure, and give the patient a secure feeling because the relining material encircles the implant head and minimizes RPD rocking. If all mini-implants have a high insertion torque, the patient can receive the final restoration with matrix pick-up (housings). Subsequently, no additional session for adjusting the RPD is needed. In this approach, the patient can directly feel and recognize the significant improvement in the RPD in many domains especially, retention, support stability, and chewing [1, 8].
Studies proved that inserting strategic implants under existing RPD improves patient satisfaction on short- and medium-term follow-up (3-years) [1, 43]. The improvement can be explained by the symmetrical distribution of the abutments and the increased number of the rests/abutments [1, 17]. Gorai S, et al. study reported a correlation between the rests number and denture usage [17].
To sum it up, using strategic implants under existing RPD upgrade the design to more favorable support type and improve patient satisfaction with the RPD on several domains like speaking, chewing, retention, stability, and support of the RPD. This improvement could be reached earlier if the patient received immediate loading [1].
In many cases, after putting into consideration the patient’s main complaint, expectation, desire, general health, intraoral/extraoral findings, evaluating the risks (do no harm) and the benefits of bone grafting and several implants, the dentist is able to provide his patient with one or few strategic standard or mini-implants that can satisfy the patients’ needs
Strategic implants can also improve chewing ability, stabilize the occlusion, increase bite force and improve patient oral health-related quality of life. Moreover, better distribution of occlusal forces that may reduce bone resorption may be gained. Furthermore, strategic implants can improve comfort, confidence, and esthetics by reducing the RPD size and removing metal clasps from the esthetic zone.
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He is also a faculty member in the Molecular Oncology Program. He obtained his MSc and Ph.D. at Oregon State University and Texas Tech University, respectively. He pursued his postdoctoral studies at Rutgers University Medical School and the National Institutes of Health (NIH/NIDDK), USA. His research focuses on biochemistry, biophysics, genetics, molecular biology, and molecular medicine with specialization in the fields of drug design, protein structure-function, protein folding, prions, microRNA, pseudogenes, molecular cancer, epigenetics, metabolites, proteomics, genomics, protein expression, and characterization by spectroscopic and calorimetric methods.",institutionString:"University of Health Sciences",institution:null},{id:"180528",title:"Dr.",name:"Hiroyuki",middleName:null,surname:"Kagechika",slug:"hiroyuki-kagechika",fullName:"Hiroyuki Kagechika",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/180528/images/system/180528.jpg",biography:"Hiroyuki Kagechika received his bachelor’s degree and Ph.D. in Pharmaceutical Sciences from the University of Tokyo, Japan, where he served as an associate professor until 2004. He is currently a professor at the Institute of Biomaterials and Bioengineering (IBB), Tokyo Medical and Dental University (TMDU). From 2010 to 2012, he was the dean of the Graduate School of Biomedical Science. Since 2012, he has served as the vice dean of the Graduate School of Medical and Dental Sciences. He has been the director of the IBB since 2020. Dr. Kagechika’s major research interests are the medicinal chemistry of retinoids, vitamins D/K, and nuclear receptors. He has developed various compounds including a drug for acute promyelocytic leukemia.",institutionString:"Tokyo Medical and Dental University",institution:{name:"Tokyo Medical and Dental University",country:{name:"Japan"}}},{id:"94311",title:"Prof.",name:"Martins",middleName:"Ochubiojo",surname:"Ochubiojo Emeje",slug:"martins-ochubiojo-emeje",fullName:"Martins Ochubiojo Emeje",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94311/images/system/94311.jpeg",biography:"Martins Emeje obtained a BPharm with distinction from Ahmadu Bello University, Nigeria, and an MPharm and Ph.D. from the University of Nigeria (UNN), where he received the best Ph.D. award and was enlisted as UNN’s “Face of Research.” He established the first nanomedicine center in Nigeria and was the pioneer head of the intellectual property and technology transfer as well as the technology innovation and support center. Prof. Emeje’s several international fellowships include the prestigious Raman fellowship. He has published more than 150 articles and patents. He is also the head of R&D at NIPRD and holds a visiting professor position at Nnamdi Azikiwe University, Nigeria. He has a postgraduate certificate in Project Management from Walden University, Minnesota, as well as a professional teaching certificate and a World Bank certification in Public Procurement. Prof. Emeje was a national chairman of academic pharmacists in Nigeria and the 2021 winner of the May & Baker Nigeria Plc–sponsored prize for professional service in research and innovation.",institutionString:"National Institute for Pharmaceutical Research and Development",institution:{name:"National Institute for Pharmaceutical Research and Development",country:{name:"Nigeria"}}},{id:"268659",title:"Ms.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/268659/images/8143_n.jpg",biography:"Dr. Zhan received his undergraduate and graduate training in the fields of preventive medicine and epidemiology and statistics at the West China University of Medical Sciences in China during 1989 to 1999. He received his post-doctoral training in oncology and cancer proteomics for two years at the Cancer Research Institute of Human Medical University in China. In 2001, he went to the University of Tennessee Health Science Center (UTHSC) in USA, where he was a post-doctoral researcher and focused on mass spectrometry and cancer proteomics. Then, he was appointed as an Assistant Professor of Neurology, UTHSC in 2005. He moved to the Cleveland Clinic in USA as a Project Scientist/Staff in 2006 where he focused on the studies of eye disease proteomics and biomarkers. He returned to UTHSC as an Assistant Professor of Neurology in the end of 2007, engaging in proteomics and biomarker studies of lung diseases and brain tumors, and initiating the studies of predictive, preventive, and personalized medicine (PPPM) in cancer. In 2010, he was promoted to Associate Professor of Neurology, UTHSC. Currently, he is a Professor at Xiangya Hospital of Central South University in China, Fellow of Royal Society of Medicine (FRSM), the European EPMA National Representative in China, Regular Member of American Association for the Advancement of Science (AAAS), European Cooperation of Science and Technology (e-COST) grant evaluator, Associate Editors of BMC Genomics, BMC Medical Genomics, EPMA Journal, and Frontiers in Endocrinology, Executive Editor-in-Chief of Med One. He has\npublished 116 peer-reviewed research articles, 16 book chapters, 2 books, and 2 US patents. His current main research interest focuses on the studies of cancer proteomics and biomarkers, and the use of modern omics techniques and systems biology for PPPM in cancer, and on the development and use of 2DE-LC/MS for the large-scale study of human proteoforms.",institutionString:null,institution:{name:"Xiangya Hospital Central South University",country:{name:"China"}}},{id:"40482",title:null,name:"Rizwan",middleName:null,surname:"Ahmad",slug:"rizwan-ahmad",fullName:"Rizwan Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/40482/images/system/40482.jpeg",biography:"Dr. Rizwan Ahmad is a University Professor and Coordinator, Quality and Development, College of Medicine, Imam Abdulrahman bin Faisal University, Saudi Arabia. Previously, he was Associate Professor of Human Function, Oman Medical College, Oman, and SBS University, Dehradun. Dr. Ahmad completed his education at Aligarh Muslim University, Aligarh. He has published several articles in peer-reviewed journals, chapters, and edited books. His area of specialization is free radical biochemistry and autoimmune diseases.",institutionString:"Imam Abdulrahman Bin Faisal University",institution:{name:"Imam Abdulrahman Bin Faisal University",country:{name:"Saudi Arabia"}}},{id:"41865",title:"Prof.",name:"Farid A.",middleName:null,surname:"Badria",slug:"farid-a.-badria",fullName:"Farid A. Badria",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/41865/images/system/41865.jpg",biography:"Farid A. Badria, Ph.D., is the recipient of several awards, including The World Academy of Sciences (TWAS) Prize for Public Understanding of Science; the World Intellectual Property Organization (WIPO) Gold Medal for best invention; Outstanding Arab Scholar, Kuwait; and the Khwarizmi International Award, Iran. He has 250 publications, 12 books, 20 patents, and several marketed pharmaceutical products to his credit. 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He has more than sixteen years of teaching experience and has supervised numerous postgraduate and Ph.D. students. He has to his credit more than seventy papers in SCI- and SCOPUS-indexed journals, fifty-five conference proceedings, four books, six Best Paper Awards, and five projects from different government agencies. He is currently an editorial board member of eight international journals and a reviewer for more than fifty scientific journals. He received Top Reviewer and Excellent Peer Reviewer Awards from Publons in 2016 and 2017, respectively. He is also on the panel of The International Reviewer for reviewing research proposals for grants from the Royal Society. He also serves as a Publons Academy mentor and Bentham brand ambassador.",institutionString:"Punjab Technical University",institution:{name:"Punjab Technical University",country:{name:"India"}}},{id:"142388",title:"Dr.",name:"Thiago",middleName:"Gomes",surname:"Gomes Heck",slug:"thiago-gomes-heck",fullName:"Thiago Gomes Heck",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/142388/images/7259_n.jpg",biography:null,institutionString:null,institution:{name:"Universidade Regional do Noroeste do Estado do Rio Grande do Sul",country:{name:"Brazil"}}},{id:"336273",title:"Assistant Prof.",name:"Janja",middleName:null,surname:"Zupan",slug:"janja-zupan",fullName:"Janja Zupan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/336273/images/14853_n.jpeg",biography:"Janja Zupan graduated in 2005 at the Department of Clinical Biochemistry (superviser prof. dr. Janja Marc) in the field of genetics of osteoporosis. Since November 2009 she is working as a Teaching Assistant at the Faculty of Pharmacy, Department of Clinical Biochemistry. In 2011 she completed part of her research and PhD work at Institute of Genetics and Molecular Medicine, University of Edinburgh. She finished her PhD entitled The influence of the proinflammatory cytokines on the RANK/RANKL/OPG in bone tissue of osteoporotic and osteoarthritic patients in 2012. From 2014-2016 she worked at the Institute of Biomedical Sciences, University of Aberdeen as a postdoctoral research fellow on UK Arthritis research project where she gained knowledge in mesenchymal stem cells and regenerative medicine. She returned back to University of Ljubljana, Faculty of Pharmacy in 2016. She is currently leading project entitled Mesenchymal stem cells-the keepers of tissue endogenous regenerative capacity facing up to aging of the musculoskeletal system funded by Slovenian Research Agency.",institutionString:null,institution:{name:"University of Ljubljana",country:{name:"Slovenia"}}},{id:"357453",title:"Dr.",name:"Radheshyam",middleName:null,surname:"Maurya",slug:"radheshyam-maurya",fullName:"Radheshyam Maurya",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/357453/images/16535_n.jpg",biography:null,institutionString:null,institution:{name:"University of Hyderabad",country:{name:"India"}}},{id:"418340",title:"Dr.",name:"Jyotirmoi",middleName:null,surname:"Aich",slug:"jyotirmoi-aich",fullName:"Jyotirmoi Aich",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000038Ugi5QAC/Profile_Picture_2022-04-15T07:48:28.png",biography:"Biotechnologist with 15 years of research including 6 years of teaching experience. Demonstrated record of scientific achievements through consistent publication record (H index = 13, with 874 citations) in high impact journals such as Nature Communications, Oncotarget, Annals of Oncology, PNAS, and AJRCCM, etc. Strong research professional with a post-doctorate from ACTREC where I gained experimental oncology experience in clinical settings and a doctorate from IGIB where I gained expertise in asthma pathophysiology. A well-trained biotechnologist with diverse experience on the bench across different research themes ranging from asthma to cancer and other infectious diseases. An individual with a strong commitment and innovative mindset. Have the ability to work on diverse projects such as regenerative and molecular medicine with an overall mindset of improving healthcare.",institutionString:"DY Patil Deemed to Be University",institution:null},{id:"349288",title:"Prof.",name:"Soumya",middleName:null,surname:"Basu",slug:"soumya-basu",fullName:"Soumya Basu",position:null,profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0033Y000035QxIDQA0/Profile_Picture_2022-04-15T07:47:01.jpg",biography:"Soumya Basu, Ph.D., is currently working as an Associate Professor at Dr. D. Y. Patil Biotechnology and Bioinformatics Institute, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India. With 16+ years of trans-disciplinary research experience in Drug Design, development, and pre-clinical validation; 20+ research article publications in journals of repute, 9+ years of teaching experience, trained with cross-disciplinary education, Dr. Basu is a life-long learner and always thrives for new challenges.\r\nHer research area is the design and synthesis of small molecule partial agonists of PPAR-γ in lung cancer. She is also using artificial intelligence and deep learning methods to understand the exosomal miRNA’s role in cancer metastasis. Dr. Basu is the recipient of many awards including the Early Career Research Award from the Department of Science and Technology, Govt. of India. She is a reviewer of many journals like Molecular Biology Reports, Frontiers in Oncology, RSC Advances, PLOS ONE, Journal of Biomolecular Structure & Dynamics, Journal of Molecular Graphics and Modelling, etc. She has edited and authored/co-authored 21 journal papers, 3 book chapters, and 15 abstracts. She is a Board of Studies member at her university. She is a life member of 'The Cytometry Society”-in India and 'All India Cell Biology Society”- in India.",institutionString:"Dr. D.Y. Patil Vidyapeeth, Pune",institution:{name:"Dr. D.Y. Patil Vidyapeeth, Pune",country:{name:"India"}}},{id:"354817",title:"Dr.",name:"Anubhab",middleName:null,surname:"Mukherjee",slug:"anubhab-mukherjee",fullName:"Anubhab Mukherjee",position:null,profilePictureURL:"https://intech-files.s3.amazonaws.com/0033Y0000365PbRQAU/ProfilePicture%202022-04-15%2005%3A11%3A18.480",biography:"A former member of Laboratory of Nanomedicine, Brigham and Women’s Hospital, Harvard University, Boston, USA, Dr. Anubhab Mukherjee is an ardent votary of science who strives to make an impact in the lives of those afflicted with cancer and other chronic/acute ailments. He completed his Ph.D. from CSIR-Indian Institute of Chemical Technology, Hyderabad, India, having been skilled with RNAi, liposomal drug delivery, preclinical cell and animal studies. He pursued post-doctoral research at College of Pharmacy, Health Science Center, Texas A & M University and was involved in another postdoctoral research at Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute, Santa Monica, California. In 2015, he worked in Harvard-MIT Health Sciences & Technology as a visiting scientist. He has substantial experience in nanotechnology-based formulation development and successfully served various Indian organizations to develop pharmaceuticals and nutraceutical products. He is an inventor in many US patents and an author in many peer-reviewed articles, book chapters and books published in various media of international repute. Dr. Mukherjee is currently serving as Principal Scientist, R&D at Esperer Onco Nutrition (EON) Pvt. Ltd. and heads the Hyderabad R&D center of the organization.",institutionString:"Esperer Onco Nutrition Pvt Ltd.",institution:null},{id:"319365",title:"Assistant Prof.",name:"Manash K.",middleName:null,surname:"Paul",slug:"manash-k.-paul",fullName:"Manash K. Paul",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/319365/images/system/319365.png",biography:"Manash K. Paul is a Principal Investigator and Scientist at the University of California Los Angeles. He has contributed significantly to the fields of stem cell biology, regenerative medicine, and lung cancer. His research focuses on various signaling processes involved in maintaining stem cell homeostasis during the injury-repair process, deciphering lung stem cell niche, pulmonary disease modeling, immuno-oncology, and drug discovery. He is currently investigating the role of extracellular vesicles in premalignant lung cell migration and detecting the metastatic phenotype of lung cancer via machine-learning-based analyses of exosomal signatures. Dr. Paul has published in more than fifty peer-reviewed international journals and is highly cited. He is the recipient of many awards, including the UCLA Vice Chancellor’s award, a senior member of the Institute of Electrical and Electronics Engineers (IEEE), and an editorial board member for several international journals.",institutionString:"University of California Los Angeles",institution:{name:"University of California Los Angeles",country:{name:"United States of America"}}},{id:"311457",title:"Dr.",name:"Júlia",middleName:null,surname:"Scherer Santos",slug:"julia-scherer-santos",fullName:"Júlia Scherer Santos",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/311457/images/system/311457.jpg",biography:"Dr. Júlia Scherer Santos works in the areas of cosmetology, nanotechnology, pharmaceutical technology, beauty, and aesthetics. Dr. Santos also has experience as a professor of graduate courses. Graduated in Pharmacy, specialization in Cosmetology and Cosmeceuticals applied to aesthetics, specialization in Aesthetic and Cosmetic Health, and a doctorate in Pharmaceutical Nanotechnology. Teaching experience in Pharmacy and Aesthetics and Cosmetics courses. She works mainly on the following subjects: nanotechnology, cosmetology, pharmaceutical technology, aesthetics.",institutionString:"Universidade Federal de Juiz de Fora",institution:{name:"Universidade Federal de Juiz de Fora",country:{name:"Brazil"}}},{id:"219081",title:"Dr.",name:"Abdulsamed",middleName:null,surname:"Kükürt",slug:"abdulsamed-kukurt",fullName:"Abdulsamed Kükürt",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/219081/images/system/219081.png",biography:"Dr. Kükürt graduated from Uludağ University in Turkey. He started his academic career as a Research Assistant in the Department of Biochemistry at Kafkas University. In 2019, he completed his Ph.D. program in the Department of Biochemistry at the Institute of Health Sciences. He is currently working at the Department of Biochemistry, Kafkas University. He has 27 published research articles in academic journals, 11 book chapters, and 37 papers. He took part in 10 academic projects. He served as a reviewer for many articles. He still serves as a member of the review board in many academic journals. He is currently working on the protective activity of phenolic compounds in disorders associated with oxidative stress and inflammation.",institutionString:null,institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"178366",title:"Dr.",name:"Volkan",middleName:null,surname:"Gelen",slug:"volkan-gelen",fullName:"Volkan Gelen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/178366/images/system/178366.jpg",biography:"Volkan Gelen is a Physiology specialist who received his veterinary degree from Kafkas University in 2011. Between 2011-2015, he worked as an assistant at Atatürk University, Faculty of Veterinary Medicine, Department of Physiology. In 2016, he joined Kafkas University, Faculty of Veterinary Medicine, Department of Physiology as an assistant professor. Dr. Gelen has been engaged in various academic activities at Kafkas University since 2016. There he completed 5 projects and has 3 ongoing projects. He has 60 articles published in scientific journals and 20 poster presentations in scientific congresses. His research interests include physiology, endocrine system, cancer, diabetes, cardiovascular system diseases, and isolated organ bath system studies.",institutionString:"Kafkas University",institution:{name:"Kafkas University",country:{name:"Turkey"}}},{id:"418963",title:"Dr.",name:"Augustine Ododo",middleName:"Augustine",surname:"Osagie",slug:"augustine-ododo-osagie",fullName:"Augustine Ododo Osagie",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/418963/images/16900_n.jpg",biography:"Born into the family of Osagie, a prince of the Benin Kingdom. I am currently an academic in the Department of Medical Biochemistry, University of Benin. Part of the duties are to teach undergraduate students and conduct academic research.",institutionString:null,institution:{name:"University of Benin",country:{name:"Nigeria"}}},{id:"192992",title:"Prof.",name:"Shagufta",middleName:null,surname:"Perveen",slug:"shagufta-perveen",fullName:"Shagufta Perveen",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/192992/images/system/192992.png",biography:"Prof. Shagufta Perveen is a Distinguish Professor in the Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. Dr. Perveen has acted as the principal investigator of major research projects funded by the research unit of King Saud University. She has more than ninety original research papers in peer-reviewed journals of international repute to her credit. She is a fellow member of the Royal Society of Chemistry UK and the American Chemical Society of the United States.",institutionString:"King Saud University",institution:{name:"King Saud University",country:{name:"Saudi Arabia"}}},{id:"49848",title:"Dr.",name:"Wen-Long",middleName:null,surname:"Hu",slug:"wen-long-hu",fullName:"Wen-Long Hu",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/49848/images/system/49848.jpg",biography:"Wen-Long Hu is Chief of the Division of Acupuncture, Department of Chinese Medicine at Kaohsiung Chang Gung Memorial Hospital, as well as an adjunct associate professor at Fooyin University and Kaohsiung Medical University. Wen-Long is President of Taiwan Traditional Chinese Medicine Medical Association. He has 28 years of experience in clinical practice in laser acupuncture therapy and 34 years in acupuncture. He is an invited speaker for lectures and workshops in laser acupuncture at many symposiums held by medical associations. He owns the patent for herbal preparation and producing, and for the supercritical fluid-treated needle. Dr. Hu has published three books, 12 book chapters, and more than 30 papers in reputed journals, besides serving as an editorial board member of repute.",institutionString:"Kaohsiung Chang Gung Memorial Hospital",institution:{name:"Kaohsiung Chang Gung Memorial Hospital",country:{name:"Taiwan"}}},{id:"298472",title:"Prof.",name:"Andrey V.",middleName:null,surname:"Grechko",slug:"andrey-v.-grechko",fullName:"Andrey V. Grechko",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/298472/images/system/298472.png",biography:"Andrey Vyacheslavovich Grechko, Ph.D., Professor, is a Corresponding Member of the Russian Academy of Sciences. He graduated from the Semashko Moscow Medical Institute (Semashko National Research Institute of Public Health) with a degree in Medicine (1998), the Clinical Department of Dermatovenerology (2000), and received a second higher education in Psychology (2009). Professor A.V. Grechko held the position of Сhief Physician of the Central Clinical Hospital in Moscow. He worked as a professor at the faculty and was engaged in scientific research at the Medical University. Starting in 2013, he has been the initiator of the creation of the Federal Scientific and Clinical Center for Intensive Care and Rehabilitology, Moscow, Russian Federation, where he also serves as Director since 2015. He has many years of experience in research and teaching in various fields of medicine, is an author/co-author of more than 200 scientific publications, 13 patents, 15 medical books/chapters, including Chapter in Book «Metabolomics», IntechOpen, 2020 «Metabolomic Discovery of Microbiota Dysfunction as the Cause of Pathology».",institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"199461",title:"Prof.",name:"Natalia V.",middleName:null,surname:"Beloborodova",slug:"natalia-v.-beloborodova",fullName:"Natalia V. Beloborodova",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/199461/images/system/199461.jpg",biography:'Natalia Vladimirovna Beloborodova was educated at the Pirogov Russian National Research Medical University, with a degree in pediatrics in 1980, a Ph.D. in 1987, and a specialization in Clinical Microbiology from First Moscow State Medical University in 2004. She has been a Professor since 1996. Currently, she is the Head of the Laboratory of Metabolism, a division of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russian Federation. N.V. Beloborodova has many years of clinical experience in the field of intensive care and surgery. She studies infectious complications and sepsis. She initiated a series of interdisciplinary clinical and experimental studies based on the concept of integrating human metabolism and its microbiota. Her scientific achievements are widely known: she is the recipient of the Marie E. Coates Award \\"Best lecturer-scientist\\" Gustafsson Fund, Karolinska Institutes, Stockholm, Sweden, and the International Sepsis Forum Award, Pasteur Institute, Paris, France (2014), etc. Professor N.V. Beloborodova wrote 210 papers, five books, 10 chapters and has edited four books.',institutionString:"Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology",institution:null},{id:"354260",title:"Ph.D.",name:"Tércio Elyan",middleName:"Azevedo",surname:"Azevedo Martins",slug:"tercio-elyan-azevedo-martins",fullName:"Tércio Elyan Azevedo Martins",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/354260/images/16241_n.jpg",biography:"Graduated in Pharmacy from the Federal University of Ceará with the modality in Industrial Pharmacy, Specialist in Production and Control of Medicines from the University of São Paulo (USP), Master in Pharmaceuticals and Medicines from the University of São Paulo (USP) and Doctor of Science in the program of Pharmaceuticals and Medicines by the University of São Paulo. Professor at Universidade Paulista (UNIP) in the areas of chemistry, cosmetology and trichology. Assistant Coordinator of the Higher Course in Aesthetic and Cosmetic Technology at Universidade Paulista Campus Chácara Santo Antônio. Experience in the Pharmacy area, with emphasis on Pharmacotechnics, Pharmaceutical Technology, Research and Development of Cosmetics, acting mainly on topics such as cosmetology, antioxidant activity, aesthetics, photoprotection, cyclodextrin and thermal analysis.",institutionString:null,institution:{name:"University of Sao Paulo",country:{name:"Brazil"}}},{id:"334285",title:"Ph.D. Student",name:"Sameer",middleName:"Kumar",surname:"Jagirdar",slug:"sameer-jagirdar",fullName:"Sameer Jagirdar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/334285/images/14691_n.jpg",biography:"I\\'m a graduate student at the center for biosystems science and engineering at the Indian Institute of Science, Bangalore, India. I am interested in studying host-pathogen interactions at the biomaterial interface.",institutionString:null,institution:{name:"Indian Institute of Science Bangalore",country:{name:"India"}}},{id:"329248",title:"Dr.",name:"Md. Faheem",middleName:null,surname:"Haider",slug:"md.-faheem-haider",fullName:"Md. Faheem Haider",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329248/images/system/329248.jpg",biography:"Dr. Md. Faheem Haider completed his BPharm in 2012 at Integral University, Lucknow, India. In 2014, he completed his MPharm with specialization in Pharmaceutics at Babasaheb Bhimrao Ambedkar University, Lucknow, India. He received his Ph.D. degree from Jamia Hamdard University, New Delhi, India, in 2018. He was selected for the GPAT six times and his best All India Rank was 34. Currently, he is an assistant professor at Integral University. Previously he was an assistant professor at IIMT University, Meerut, India. He has experience teaching DPharm, Pharm.D, BPharm, and MPharm students. He has more than five publications in reputed journals to his credit. Dr. Faheem’s research area is the development and characterization of nanoformulation for the delivery of drugs to various organs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"329795",title:"Dr.",name:"Mohd Aftab",middleName:"Aftab",surname:"Siddiqui",slug:"mohd-aftab-siddiqui",fullName:"Mohd Aftab Siddiqui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/329795/images/system/329795.png",biography:"Dr. Mohd Aftab Siddiqui is an assistant professor in the Faculty of Pharmacy, Integral University, Lucknow, India, where he obtained a Ph.D. in Pharmacology in 2020. He also obtained a BPharm and MPharm from the same university in 2013 and 2015, respectively. His area of research is the pharmacological screening of herbal drugs/natural products in liver cancer and cardiac diseases. He is a member of many professional bodies and has guided many MPharm and PharmD research projects. Dr. Siddiqui has many national and international publications and one German patent to his credit.",institutionString:"Integral University",institution:null},{id:"255360",title:"Dr.",name:"Usama",middleName:null,surname:"Ahmad",slug:"usama-ahmad",fullName:"Usama Ahmad",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/255360/images/system/255360.png",biography:"Dr. Usama Ahmad holds a specialization in Pharmaceutics from Amity University, Lucknow, India. He received his Ph.D. from Integral University, Lucknow, India, with his work titled ‘Development and evaluation of silymarin nanoformulation for hepatic carcinoma’. Currently, he is an Assistant Professor of Pharmaceutics, at the Faculty of Pharmacy, Integral University. He has been teaching PharmD, BPharm, and MPharm students and conducting research in the novel drug delivery domain. From 2013 to 2014 he worked on a research project funded by SERB-DST, Government of India. He has a rich publication record with more than twenty-four original journal articles, two edited books, four book chapters, and several scientific articles to his credit. He is a member of the American Association for Cancer Research, the International Association for the Study of Lung Cancer, and the British Society for Nanomedicine. Dr. Ahmad’s research focus is on the development of nanoformulations to facilitate the delivery of drugs.",institutionString:"Integral University",institution:{name:"Integral University",country:{name:"India"}}},{id:"333824",title:"Dr.",name:"Ahmad Farouk",middleName:null,surname:"Musa",slug:"ahmad-farouk-musa",fullName:"Ahmad Farouk Musa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/333824/images/22684_n.jpg",biography:"Dato’ Dr Ahmad Farouk Musa\nMD, MMED (Surgery) (Mal), Fellowship in Cardiothoracic Surgery (Monash Health, Aust), Graduate Certificate in Higher Education (Aust), Academy of Medicine (Mal)\n\n\n\nDato’ Dr Ahmad Farouk Musa obtained his Doctor of Medicine from USM in 1992. He then obtained his Master of Medicine in Surgery from the same university in the year 2000 before subspecialising in Cardiothoracic Surgery at Institut Jantung Negara (IJN), Kuala Lumpur from 2002 until 2005. He then completed his Fellowship in Cardiothoracic Surgery at Monash Health, Melbourne, Australia in 2008. He has served in the Malaysian army as a Medical Officer with the rank of Captain upon completing his Internship before joining USM as a trainee lecturer. He is now serving as an academic and researcher at Monash University Malaysia. He is a life-member of the Malaysian Association of Thoracic & Cardiovascular Surgery (MATCVS) and a committee member of the MATCVS Database. He is also a life-member of the College of Surgeons, Academy of Medicine of Malaysia; a life-member of Malaysian Medical Association (MMA), and a life-member of Islamic Medical Association of Malaysia (IMAM). Recently he was appointed as an Interim Chairperson of Examination & Assessment Subcommittee of the UiTM-IJN Cardiothoracic Surgery Postgraduate Program. As an academic, he has published numerous research papers and book chapters. He has also been appointed to review many scientific manuscripts by established journals such as the British Medical Journal (BMJ). He has presented his research works at numerous local and international conferences such as the European Association for Cardiothoracic Surgery (EACTS) and the European Society of Cardiovascular Surgery (ESCVS), to name a few. He has also won many awards for his research presentations at meetings and conferences like the prestigious International Invention, Innovation & Technology Exhibition (ITEX); Design, Research and Innovation Exhibition, the National Conference on Medical Sciences and the Annual Scientific Meetings of the Malaysian Association for Thoracic and Cardiovascular Surgery. He was awarded the Darjah Setia Pangkuan Negeri (DSPN) by the Governor of Penang in July, 2015.",institutionString:null,institution:{name:"Monash University Malaysia",country:{name:"Malaysia"}}},{id:"30568",title:"Prof.",name:"Madhu",middleName:null,surname:"Khullar",slug:"madhu-khullar",fullName:"Madhu Khullar",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/30568/images/system/30568.jpg",biography:"Dr. Madhu Khullar is a Professor of Experimental Medicine and Biotechnology at the Post Graduate Institute of Medical Education and Research, Chandigarh, India. She completed her Post Doctorate in hypertension research at the Henry Ford Hospital, Detroit, USA in 1985. She is an editor and reviewer of several international journals, and a fellow and member of several cardiovascular research societies. Dr. Khullar has a keen research interest in genetics of hypertension, and is currently studying pharmacogenetics of hypertension.",institutionString:"Post Graduate Institute of Medical Education and Research",institution:{name:"Post Graduate Institute of Medical Education and Research",country:{name:"India"}}},{id:"223233",title:"Prof.",name:"Xianquan",middleName:null,surname:"Zhan",slug:"xianquan-zhan",fullName:"Xianquan Zhan",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/223233/images/system/223233.png",biography:"Xianquan Zhan received his MD and Ph.D. in Preventive Medicine at West China University of Medical Sciences. He received his post-doctoral training in oncology and cancer proteomics at the Central South University, China, and the University of Tennessee Health Science Center (UTHSC), USA. He worked at UTHSC and the Cleveland Clinic in 2001–2012 and achieved the rank of associate professor at UTHSC. Currently, he is a full professor at Central South University and Shandong First Medical University, and an advisor to MS/PhD students and postdoctoral fellows. He is also a fellow of the Royal Society of Medicine and European Association for Predictive Preventive Personalized Medicine (EPMA), a national representative of EPMA, and a member of the American Society of Clinical Oncology (ASCO) and the American Association for the Advancement of Sciences (AAAS). He is also the editor in chief of International Journal of Chronic Diseases & Therapy, an associate editor of EPMA Journal, Frontiers in Endocrinology, and BMC Medical Genomics, and a guest editor of Mass Spectrometry Reviews, Frontiers in Endocrinology, EPMA Journal, and Oxidative Medicine and Cellular Longevity. He has published more than 148 articles, 28 book chapters, 6 books, and 2 US patents in the field of clinical proteomics and biomarkers.",institutionString:"Shandong First Medical University",institution:{name:"Affiliated Hospital of Shandong Academy of Medical Sciences",country:{name:"China"}}}]}},subseries:{item:{id:"4",type:"subseries",title:"Fungal Infectious Diseases",keywords:"Emerging Fungal Pathogens, Invasive Infections, Epidemiology, Cell Membrane, Fungal Virulence, Diagnosis, Treatment",scope:"Fungi are ubiquitous and there are almost no non-pathogenic fungi. Fungal infectious illness prevalence and prognosis are determined by the exposure between fungi and host, host immunological state, fungal virulence, and early and accurate diagnosis and treatment. \r\nPatients with both congenital and acquired immunodeficiency are more likely to be infected with opportunistic mycosis. Fungal infectious disease outbreaks are common during the post- disaster rebuilding era, which is characterised by high population density, migration, and poor health and medical conditions.\r\nSystemic or local fungal infection is mainly associated with the fungi directly inhaled or inoculated in the environment during the disaster. The most common fungal infection pathways are human to human (anthropophilic), animal to human (zoophilic), and environment to human (soilophile). Diseases are common as a result of widespread exposure to pathogenic fungus dispersed into the environment. \r\nFungi that are both common and emerging are intertwined. In Southeast Asia, for example, Talaromyces marneffei is an important pathogenic thermally dimorphic fungus that causes systemic mycosis. Widespread fungal infections with complicated and variable clinical manifestations, such as Candida auris infection resistant to several antifungal medicines, Covid-19 associated with Trichoderma, and terbinafine resistant dermatophytosis in India, are among the most serious disorders. \r\nInappropriate local or systemic use of glucocorticoids, as well as their immunosuppressive effects, may lead to changes in fungal infection spectrum and clinical characteristics. Hematogenous candidiasis is a worrisome issue that affects people all over the world, particularly ICU patients. CARD9 deficiency and fungal infection have been major issues in recent years. Invasive aspergillosis is associated with a significant death rate. Special attention should be given to endemic fungal infections, identification of important clinical fungal infections advanced in yeasts, filamentous fungal infections, skin mycobiome and fungal genomes, and immunity to fungal infections.\r\nIn addition, endemic fungal diseases or uncommon fungal infections caused by Mucor irregularis, dermatophytosis, Malassezia, cryptococcosis, chromoblastomycosis, coccidiosis, blastomycosis, histoplasmosis, sporotrichosis, and other fungi, should be monitored. \r\nThis topic includes the research progress on the etiology and pathogenesis of fungal infections, new methods of isolation and identification, rapid detection, drug sensitivity testing, new antifungal drugs, schemes and case series reports. It will provide significant opportunities and support for scientists, clinical doctors, mycologists, antifungal drug researchers, public health practitioners, and epidemiologists from all over the world to share new research, ideas and solutions to promote the development and progress of medical mycology.",coverUrl:"https://cdn.intechopen.com/series_topics/covers/4.jpg",hasOnlineFirst:!0,hasPublishedBooks:!1,annualVolume:11400,editor:{id:"174134",title:"Dr.",name:"Yuping",middleName:null,surname:"Ran",slug:"yuping-ran",fullName:"Yuping Ran",profilePictureURL:"https://s3.us-east-1.amazonaws.com/intech-files/0030O00002bS9d6QAC/Profile_Picture_1630330675373",biography:"Dr. Yuping Ran, Professor, Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China. Completed the Course Medical Mycology, the Centraalbureau voor Schimmelcultures (CBS), Fungal Biodiversity Centre, Netherlands (2006). International Union of Microbiological Societies (IUMS) Fellow, and International Emerging Infectious Diseases (IEID) Fellow, Centers for Diseases Control and Prevention (CDC), Atlanta, USA. Diploma of Dermatological Scientist, Japanese Society for Investigative Dermatology. Ph.D. of Juntendo University, Japan. Bachelor’s and Master’s degree, Medicine, West China University of Medical Sciences. Chair of Sichuan Medical Association Dermatology Committee. General Secretary of The 19th Annual Meeting of Chinese Society of Dermatology and the Asia Pacific Society for Medical Mycology (2013). In charge of the Annual Medical Mycology Course over 20-years authorized by National Continue Medical Education Committee of China. Member of the board of directors of the Asia-Pacific Society for Medical Mycology (APSMM). Associate editor of Mycopathologia. Vice-chief of the editorial board of Chinses Journal of Mycology, China. Board Member and Chair of Mycology Group of Chinese Society of Dermatology.",institutionString:null,institution:{name:"Sichuan University",institutionURL:null,country:{name:"China"}}},editorTwo:null,editorThree:null,series:{id:"6",title:"Infectious Diseases",doi:"10.5772/intechopen.71852",issn:"2631-6188"},editorialBoard:[{id:"302145",title:"Dr.",name:"Felix",middleName:null,surname:"Bongomin",slug:"felix-bongomin",fullName:"Felix Bongomin",profilePictureURL:"https://mts.intechopen.com/storage/users/302145/images/system/302145.jpg",institutionString:null,institution:{name:"Gulu University",institutionURL:null,country:{name:"Uganda"}}},{id:"45803",title:"Ph.D.",name:"Payam",middleName:null,surname:"Behzadi",slug:"payam-behzadi",fullName:"Payam Behzadi",profilePictureURL:"https://mts.intechopen.com/storage/users/45803/images/system/45803.jpg",institutionString:"Islamic Azad University, Tehran",institution:{name:"Islamic Azad University, Tehran",institutionURL:null,country:{name:"Iran"}}}]},onlineFirstChapters:{paginationCount:7,paginationItems:[{id:"82405",title:"Does Board Structure Matter in CSR Spending of Commercial Banks? 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Biochemistry examines macromolecules - proteins, nucleic acids, carbohydrates, and lipids – and their building blocks, structures, functions, and interactions. Much of biochemistry is devoted to enzymes, proteins that catalyze chemical reactions, enzyme structures, mechanisms of action and their roles within cells. Biochemistry also studies small signaling molecules, coenzymes, inhibitors, vitamins, and hormones, which play roles in life processes. Biochemical experimentation, besides coopting classical chemistry methods, e.g., chromatography, adopted new techniques, e.g., X-ray diffraction, electron microscopy, NMR, radioisotopes, and developed sophisticated microbial genetic tools, e.g., auxotroph mutants and their revertants, fermentation, etc. More recently, biochemistry embraced the ‘big data’ omics systems. Initial biochemical studies have been exclusively analytic: dissecting, purifying, and examining individual components of a biological system; in the apt words of Efraim Racker (1913 –1991), “Don’t waste clean thinking on dirty enzymes.” Today, however, biochemistry is becoming more agglomerative and comprehensive, setting out to integrate and describe entirely particular biological systems. The ‘big data’ metabolomics can define the complement of small molecules, e.g., in a soil or biofilm sample; proteomics can distinguish all the comprising proteins, e.g., serum; metagenomics can identify all the genes in a complex environment, e.g., the bovine rumen. 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Dr. Blumenberg’s research is focused on the epidermis, expression of keratin genes, transcription profiling, keratinocyte differentiation, inflammatory diseases and cancers, and most recently the effects of the microbiome on the skin. 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In recent years, the application of chemistry to biological molecules has gained significant interest in medicinal and pharmacological studies. This topic will be devoted to understanding the interplay between biomolecules and chemical compounds, their structure and function, and their potential applications in related fields. Being a part of the biochemistry discipline, the ideas and concepts that have emerged from Chemical Biology have affected other related areas. 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Behind these definitions are hidden all the aspects of normal and pathological functioning of all processes that the topic ‘Metabolism’ will cover within the Biochemistry Series. 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Thus proteomics, an area of research that detects all protein forms expressed in an organism, including splice isoforms and post-translational modifications, is more suitable than genomics for a comprehensive understanding of the biochemical processes that govern life. The most common proteomics applications are currently in the clinical field for the identification, in a variety of biological matrices, of biomarkers for diagnosis and therapeutic intervention of disorders. From the comparison of proteomic profiles of control and disease or different physiological states, which may emerge, changes in protein expression can provide new insights into the roles played by some proteins in human pathologies. Understanding how proteins function and interact with each other is another goal of proteomics that makes this approach even more intriguing. Specialized technology and expertise are required to assess the proteome of any biological sample. Currently, proteomics relies mainly on mass spectrometry (MS) combined with electrophoretic (1 or 2-DE-MS) and/or chromatographic techniques (LC-MS/MS). MS is an excellent tool that has gained popularity in proteomics because of its ability to gather a complex body of information such as cataloging protein expression, identifying protein modification sites, and defining protein interactions. 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