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Engineering » Biomedical Engineering » "Biosensors for Health, Environment and Biosecurity", book edited by Pier Andrea Serra, ISBN 978-953-307-443-6, Published: July 19, 2011 under CC BY-NC-SA 3.0 license. © The Author(s).

Chapter 12

Detecting hypoglycemia by using the brain as a biosensor

By Rasmus Elsborg, Line Remvig, Henning Beck-Nielsen and Claus Juhl
DOI: 10.5772/17018

  1. S. A. Amiel, R. C. Pottinger, H. R. Archibald, G. Chusney, D. T. Cunnah, P. F. Prior, E. A. Gale, 1991 Effect of antecedent glucose control on cerebral function during hypoglycemia. Diabetes Care, 14 2 109 118 .

  2. T. Anderbro, S. Amsberg, U. Adamson, J. Bolinder, P. E. Lins, R. Wredling, E. Moberg, J. Lisspers, U. B. Johansson, 2010 Fear of hypoglycaemia in adults with Type 1 diabetes. Diabet Med, 27 10 1151 1158 .

  3. K. Barnard, S. Thomas, P. Royle, K. Noyes, N. Waugh, 2010 Fear of hypoglycaemia in parents of young children with type 1 diabetes: a systematic review. BMC Pediatr, 10:50.

  4. I. Bendtson, J. Gade, A. M. Rosenfalck, CE Thomsen, G. Wildschiodtz, C. Binder, 1991 Nocturnal electroencephalogram registrations in type 1 (insulin-dependent) diabetic patients with hypoglycaemia. Diabetologia, 34 10 750 756 .

  5. R. M. Bergenstal, W. V. Tamborlane, A. Ahmann, J. B. Buse, G. Dailey, S. N. Davis, C. Joyce, T. Peoples, BA Perkins, J. B. Welsh, S. M. Willi, MA Wood, 2010 Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes. N Engl J Med, 363 4 311 320 .

  6. M. Bjorgaas, T. Sand, T. Vik, R. Jorde, 1998 Quantitative EEG during controlled hypoglycaemia in diabetic and non-diabetic children. Diabet Med, 15 1 30 37 .

  7. C. M. Bishop, 1998 Neural Networks for Pattern Recognition. 1st ed. Oxford University Press, New York, USA.

  8. A. Crespel, P. Gélisse, 2005 Altas of Electroencephalography. 1st ed. John Libbey Eurotext, Montrouge, France.

  9. P. E. Cryer, 2005 Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes. Diabetes, 54 12 3592 3601 .

  10. BM. Frier, 2008 How hypoglycaemia can affect the life of a person with diabetes. Diabetes Metab Res Rev 2008 24 2 87 92 .

  11. J. Geddes, J. E. Schopman, N. N. Zammitt, BM Frier, 2008 Prevalence of impaired awareness of hypoglycaemia in adults with Type 1 diabetes. Diabet Med, 25 4 501 504 .

  12. A. E. Gold, Leod. K. M. Mac, BM Frier, 1994 Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia. Diabetes Care, 17 7 697 703 .

  13. M. Hammer, M. Lammert, S. M. Mejias, W. Kern, BM Frier, 2009 Costs of managing severe hypoglycaemia in three European countries. J Med Econ, 12 4 281 290 .

  14. K. Hojlund, M. Wildner-Christensen, O. Eshoj, C. Skjaerbaek, J. J. Holst, O. Koldkjaer, Jensen. D. Møller, H. Beck-Nielsen, 2001 Reference intervals for glucose, beta-cell polypeptides, and counterregulatory factors during prolonged fasting. Am J Physiol Endocrinol Metab, 280 1 E50 E58 .

  15. K. Howorka, J. Pumprla, B. Saletu, P. Anderer, M. Krieger, A. Schabmann, 2000 Decrease of vigilance assessed by EEG-mapping in type I diabetic patients with history of recurrent severe hypoglycaemia. Psychoneuroendocrinology, 25 1 85 105 .

  16. L. Hyllienmark, J. Maltez, A. Dandenell, J. Ludvigsson, T. Brismar, 2005 EEG abnormalities with and without relation to severe hypoglycaemia in adolescents with type 1 diabetes. Diabetologia, 48 3 412 419 .

  17. F. Iaione, J. L. Marques, 2005 Methodology for hypoglycaemia detection based on the processing.; analysis and classification of the electroencephalogram. Med Biol Eng Comput, 43 4 501 507 .

  18. C. Iber, S. Ancoli-Isreal, A. Chesson, S. F. Quan, 2007 The AASM Manual for the Scoring of Sleep and Associated Events, Rules, Terminology and Technical Specifications. 1st ed. American Academy of Sleep Medicine, Westchester, Illinois.

  19. JDRF CGM Study Group. 2010 Prolonged nocturnal hypoglycemia is common during 12 months of continuous glucose monitoring in children and adults with type 1 diabetes. Diabetes Care, 33 5 1004 1008 .

  20. JDRF CGM Study Group. 2008 Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med, 359 1464 1476 .

  21. T. Joakims, 2002 Leaning to Classify test using Support Vector Machines. 1st ed. Kluwer Academic Publishers. Boston, USA.

  22. C. B. Juhl, K. Hojlund, R. Elsborg, M. K. Poulsen, P. E. Selmar, J. J. Holst, C. Christiansen, H. Beck-Nielsen, 2010 Automated detection of hypoglycemia-induced EEG changes recorded by subcutaneous electrodes in subjects with type 1 diabetes-The brain as a biosensor. Diabetes Res Clin Pract, 88 1 22 28 .

  23. M. Lammert, M. Hammer, BM Frier, 2009 Management of severe hypoglycaemia: cultural similarities.; differences and resource consumption in three European countries. J Med Econ, 12 4 269 280 .

  24. M. Monami, N. Marchionni, E. Mannucci, 2009 Long-acting insulin analogues vs. NPH human insulin in type 1 diabetes. A meta-analysis. Diabetes Obes Metab, 11 4 372 378 .

  25. U. Pedersen-Bjergaard, S. Pramming, S. R. Heller, T. M. Wallace, A. K. Rasmussen, H. V. Jorgensen, D. R. Matthews, P. Hougaard, B. Thorsteinsson, 2004 Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selection. Diabetes Metab Res Rev, 20 6 479 486 .

  26. J. C. Pickup, A. J. Sutton, 2008 Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion. Diabet Med, 25 7 765 774 .

  27. S. Pramming, B. Thorsteinsson, B. Stigsby, C. Binder, 1988 Glycaemic threshold for changes in electroencephalograms during hypoglycaemia in patients with insulin dependent diabetes. Br Med J (Clin Res Ed) 296 6623 665 677 .

  28. S. Pramming, B. Thorsteinsson, I. Bendtson, C. Binder, 1990 The relationship between symptomatic and biochemical hypoglycaemia in insulin-dependent diabetic patients. J Intern Med, 228 6 641 646 .

  29. P. F. Regan, A. N. Browne-Mayers, 1956 Electroencephalography, frequency analysis and consciousness, a correlation during insulin-induced hypoglycemia. J Nerv Ment Dis, 124 2 142 147 .

  30. I. S. Ross, L. H. Loeser, 1951 Electroencephalographic findings in essential hypoglycemia. Electroencephalogr Clin Neurophysiol, 3 2 141 148 .

  31. S. Sigurdsson, J. Larsen, L. K. Hansen, P. A. Philipsen, H. C. Wulf, 2002 Outlier estimation and detection: Application to Skin Lesion Classification. Proceedings of IEEE International conference on acoustics.; speech and signal processing.

  32. W. V. Tamborlane, R. W. Beck, B. W. Bode, B. Buckingham, H. P. Chase, R. Clemons, R. Fiallo-Scharer, L. A. Fox, L. K. Gilliam, I. B. Hirsch, E. S. Huang, C. Kollman, A. J. Kowalski, L. Laffel, J. M. Lawrence, J. Lee, N. Mauras, M. O’Grady, K. J. Ruedy, M. Tansey, E. Tsalikian, S. Weinzimer, D. M. Wilson, H. Wolpert, T. Wysocki, Dl. Xing, 2008 Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med, 359 14 1464 1476 .

  33. G. Tamburrano, A. Lala, N. Locuratolo, F. Leonetti, P. Sbraccia, A. Giaccari, S. Busco, S. Porcu, 1988 Electroencephalography and visually evoked potentials during moderate hypoglycemia. J Clin Endocrinol Metab, 66 6 1301 1306 .

  34. The Diabetes Control and Complications Trial Research Group. 2009 The effect of continuous glucose monitoring in well-controlled type 1 diabetes. Diabetes Care, 32 8 1378 1383 .

  35. G. Tribl, K. Howorka, G. Heger, P. Anderer, H. Thoma, J. Zeitlhofer, 1996 EEG topography during insulin-induced hypoglycemia in patients with insulin-dependent diabetes mellitus. Eur Neurol, 36 5 303 309 .

  36. Enden. A. W. M. Van Den, N. A. M. Verhoeckx, 1989 Discrete-time signal processing. Prentice Hall. Hertfordshire, UK.

  37. A. Woodward, P. Weston, I. F. Casson, G. V. Gill, 2009 Nocturnal hypoglycaemia in type 1 diabetes-frequency and predictive factors. QJM, 102 9 603 607 .