Screw parameters of the mechanism.
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More than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\\n\\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\\n\\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\\n\\nAdditionally, each book published by IntechOpen contains original content and research findings.
\\n\\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\\n\\n\\n\\n
\\n"}]',published:!0,mainMedia:null},components:[{type:"htmlEditorComponent",content:'
Simba Information has released its Open Access Book Publishing 2020 - 2024 report and has again identified IntechOpen as the world’s largest Open Access book publisher by title count.
\n\nSimba Information is a leading provider for market intelligence and forecasts in the media and publishing industry. The report, published every year, provides an overview and financial outlook for the global professional e-book publishing market.
\n\nIntechOpen, De Gruyter, and Frontiers are the largest OA book publishers by title count, with IntechOpen coming in at first place with 5,101 OA books published, a good 1,782 titles ahead of the nearest competitor.
\n\nSince the first Open Access Book Publishing report published in 2016, IntechOpen has held the top stop each year.
\n\n\n\nMore than half of the publishers listed alongside IntechOpen (18 out of 30) are Social Science and Humanities publishers. IntechOpen is an exception to this as a leader in not only Open Access content but Open Access content across all scientific disciplines, including Physical Sciences, Engineering and Technology, Health Sciences, Life Science, and Social Sciences and Humanities.
\n\nOur breakdown of titles published demonstrates this with 47% PET, 31% HS, 18% LS, and 4% SSH books published.
\n\n“Even though ItechOpen has shown the potential of sci-tech books using an OA approach,” other publishers “have shown little interest in OA books.”
\n\nAdditionally, each book published by IntechOpen contains original content and research findings.
\n\nWe are honored to be among such prestigious publishers and we hope to continue to spearhead that growth in our quest to promote Open Access as a true pioneer in OA book publishing.
\n\n\n\n
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\r\n\tWhen the diverse types of wear reported in the different industrial segments are studied it is observed that, approximately, 50% of them are related to the action of “abrasive wear” and/or “micro-abrasive wear”, being occasioned, in many circumstances, by natural abrasives. In contrast, the same abrasive materials that cause tribologic damage and financial loss in machines and equipment used in mechanical, metallurgical, materials, mining industries and agricultural sector, are applied on the analysis of dental materials, biomaterials adopted in the manufacturing of orthopaedic implants and complements, as well as industrial processes of manufacturing: conventional machining processes, special machining processes, lapidation and polishing. Consequently, the researches focused on wear analysis occasioned during work become important, as well as the scientific researches with the purpose of to study and to develop materials for the benefit of the human, like materials used in dental and orthopaedic areas. Thereby, this book aims to focus on the topics mentioned above, beyond general aspects related to natural abrasives.
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He conducted his Programs of Master Degree and Doctor Degree in the Department of Mechanical Engineering of the Polytechnic School of the University of São Paulo – 2006 e 2011, respectively; in 2015, he finished the Post-Doctorate in Metallurgical and Materials Engineering, also in the Polytechnic School of the University of São Paulo. Nowadays, Ronaldo Câmara Cozza works as Titular Professor in two Universities: University Center FEI – Educational Foundation of Ignatius “Padre Sabóia de Medeiros” – Departments of Mechanical and Materials – and CEETEPS – State Center of Technological Education “Paula Souza” – Department of Mechanical Manufacturing – both in São Paulo State – Brazil, teaching “Technical Drawing”, “Mechanical Processes of Manufacturing”, “Machine Kinematics and Dynamics” and “Tribology”. Since 2003, Prof. R.C. Cozza researches the fundamentals and tribological behavior of materials under conditions of micro-abrasive wear.",institutionString:"University Center FEI – Educational Foundation of Ignatius “Padre Sabóia de Medeiros”",position:null,outsideEditionCount:0,totalCites:0,totalAuthoredChapters:"1",totalChapterViews:"0",totalEditedBooks:"0",institution:null}],coeditorOne:null,coeditorTwo:null,coeditorThree:null,coeditorFour:null,coeditorFive:null,topics:[{id:"14",title:"Materials Science",slug:"materials-science"}],chapters:null,productType:{id:"1",title:"Edited Volume",chapterContentType:"chapter",authoredCaption:"Edited by"},personalPublishingAssistant:{id:"287827",firstName:"Gordan",lastName:"Tot",middleName:null,title:"Mr.",imageUrl:"https://mts.intechopen.com/storage/users/287827/images/8493_n.png",email:"gordan@intechopen.com",biography:"As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. 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Taking into account this aspect, a simplified trailer model (Figure 1) is modelled and analysed to calculate the SRT factor for LVCs.
\nSimplified trailer model.
The tyres, suspension, fifth wheel, and chassis are directly responsible for the CG movements; these movements are dependent on the forces acting on the trailer CG, such as weight (W), disturbance forces imposed by the ground, and lateral inertial force (may\n) when the vehicle makes a turn. During cornering or evasive manoeuvres, the weight and the lateral inertial force acting on the vehicle centre of gravity cause its displacement, which can lead to vehicle rollover.
\nThe tyres system (tyres and rigid suspension) maintains contact with the ground and filters the disturbances imposed by road imperfections [3]. This system allows two motions of the vehicle: displacement in the z-direction and a roll rotation around the x-axis [4], as shown in Figure 2.
\nTyres system.
Mechanical systems can be represented by kinematic chains composed of links and joints, which facilitate their modelling and analysis [5, 6, 7].
\nThe kinematic chain of the tyres system in Figure 2 has 2-DoF (M = 2), the workspace is planar (λ = 3), and the number of independent loops is one (ν = 1). Based on the mobility equation, the kinematic chain of tyres system should be composed of five links (n = 5) and five joints (j = 5) [7].
\nTo model this system, the following considerations were taken into account:
There are up to three different components of forces acting on the tyre-ground contact i of the vehicle [8, 9, 10], as shown in Figure 3, where Fxi\n is the traction or brake force, Fyi\n is the lateral force, and Fzi\n is the normal force;
However, at rollover threshold, tyres 1 and 4 (outer tyres in the turn, Figure 4) receive greater normal force than tyres 2 and 3 (inner tyre in the turn, Figure 4), and thus tyres 1 and 4 are not prone to slide laterally. We consider that tyres 1 and 4 only allow vehicle rotation along the x-axis. Therefore, tyre-ground contact was modelled as a pure revolute joint R along x-axis.
While tyres 2 and 3 have a lateral deformation and may slide laterally, producing a track width change of their respective axles. As a consequence, tyres 2 and 3 have only a constraint on the z-direction. Therefore, tyre-ground contact was modelled as a prismatic joint P in the y-direction.
Tyres are assumed as flexible mechanical components and can be represented by prismatic joints P, [11, 12].
In vehicles with rigid suspension, tyres remain perpendicular to the axle all the time.
Movement constraints in Tyre-road contact.
Vehicle on a curved path.
Applying these constraints, Figure 5a shows the proposed kinematic chain model of the tyres system.
\n(a) Kinematic chain of the tyres system. (b) Tyres system including actuators.
The kinematic chain is composed of five links identified by letters A (road), B (outer tyre in the turn), C and D (inner tyre in the turn), and E (vehicle axle); and the five joints are identified by numbers as follows: two revolute joints R (tyre-road contact of joints 1 and 4) and three prismatic joints P, two that represent tyres of the system (2 and 5), and one the lateral slide of tyre 2 (3).
\nThe mechanism of Figure 5a has 2-DoF, and it requires two actuators to control its movement. The mechanism has a passive actuator in each prismatic joint of tyres (2 and 5—axial deformation); these actuators control the movement along the x- and z-axes, as shown in Figure 5b.
\nIn this model, the revolute joint (3) and the prismatic joint (4) can be changed by a spherical slider joint (Sd\n), with constraint in the z-axis, as shown in Figure 6.
\nTyres system model.
The movement of this system is orientated by the forces acting on the mechanism (trailer weight (W) and the inertial force (may\n)) [13]. These forces affect the passive actuators of the mechanism, as shown in Figure 7.
\nMovement of tyres system.
\nEqs. (1)–(5) define the kinematics of the tyres system.
\nwhere δT\n is the normal deformation of the tyre [14], ∆F is the algebraic change in the initial load, kt\n is the vertical stiffness of the tyre, ac\n is the regression coefficient, FTi\n is the instantaneous tyre normal load, li\n is the instantaneous dynamic rolling radius of the tyre i, \n
This system comprises the linkage between the sprung and unsprung masses of a vehicle, which reduces the movement of the sprung mass, allowing tyres to maintain contact with the ground, and filtering disturbances imposed by the ground [3]. In heavy vehicles, the suspension system most used is the leaf spring suspension or rigid suspension [15], as shown in Figure 8. For developing this model (trailer), it is assumed that the vehicle has this suspension on the front and rear axles.
\nSolid axle with leaf spring suspension. Source: Adapted from Rill et al. [15].
The rigid suspension is a mechanism that allows the following movements of the vehicle’s body under the action of lateral forces: displacement in the z- and y-direction and a roll rotation about the x-axis [1, 8], as shown in Figure 9a and b.
\n(a) Body motion. (b) Suspension system.
The system of Figure 10a has 3-DoF (M = 3), the workspace is planar (λ = 3) and the number of independent loops is one (ν = 1). From the mobility equation, the kinematic chain of suspension system should be composed of six links (n = 6) and six joints (j = 6).
\n(a) Movement of suspension system. (b) Kinematic chain of suspension system. (c) Suspension system including actuators.
To model this system the following consideration is considered: leaf springs are assumed as flexible mechanical components with an axial deformation and a small shear deformation, and can be represented by prismatic joints P supported in revolute joints R [16].
\nTo allow the rotation of the body in the z-axis, the link between the body and the leaf spring is made with revolute joint. Applying these concepts to the system, a model with the configuration shown in Figure 10b is proposed.
\nThe system is composed of six links identified by letters D (vehicle axle), E and F (spring 1), G and H (spring 2), and I (the vehicle body), and the six joints identified by the following numbers: four revolute joints R (5, 7, 8, and 10) and two prismatic joints P that represent the leaf springs of the system (6 and 9), as shown in Figure 10b.
\nThe mechanism of Figure 10b has 3-DoF, and it requires three actuators to control its movements, applying the technique developed in Section 1.1, the kinematic chain has a passive actuator in the prismatic joints 6 and 9 (axial deformation of the leaf spring), and a passive actuator in the joints 6 and 9 (torsion spring—shear deformation); but the mechanism with four passive actuators is over-constrained, in this case only one equivalent passive actuator is used in the joint 5 or 8, as shown in Figure 10c.
\nThe movement of the suspension is orientated first by the movement of the tyres system, and second by forces acting on the mechanism (vehicle weight (W) and inertial force (may\n)). These forces affect the passive actuators of the mechanism, as shown in Figure 11.
\nMovement of suspension system.
\nEqs. (6)–(12) define the kinematics of the suspension system:
\nwhere Txn\n is the moment around the x-axis on the joint n, kts\n is the spring’s torsion coefficient, δLS\n is the leaf spring deformation [17], ∆F is the algebraic change in the initial load, l is the length of the leaf spring, N is the number of leaves, B is the width of the leaf, T is the thickness of the leaf, Es\n is the modulus of elasticity of a multiple leaf, ln\n is the instantaneous height of the leaf spring n, FLSn\n is the spring normal force n, ls\n is the initial suspension height, kLs\n is the equivalent stiffness of the suspension, ln\n is the instantaneous height of the leaf spring n, b is the lateral separation between the springs, and θn\n is the rotation angle of the revolute joint n.
\nThis system is a coupling device between the tractive unit and the trailer; but in the case of a multiple trailer train, a fifth wheel also can be located on a lead trailer. The fifth wheel allows articulation between the tractive and the towed units.
\nThis system consists of a wheel-shaped deck plate usually designed to tilt or oscillate on mounting pins. The assembly is bolted to the frame of the tractive unit. A sector is cut away in the fifth wheel plate (sometimes called a throat), allowing a trailer kingpin to engage with locking jaws in the centre of the fifth wheel [18]. The trailer kingpin is mounted in the trailer upper coupler assembly. The upper coupler consists of the kingpin and the bolster plate.
\nWhen the vehicle makes different manoeuvres (starting to go uphill or downhill, and during cornering) [18], the fifth wheel allows the free movement of the trailer and more flexibility of the chassis, as shown in Figures 12–14.
\nMovement of the fifth wheel—Starting uphill. Source: Adapted from Saf-Holland [18].
Movement of the fifth wheel—Starting downhill. Source: Adapted from Saf-Holland [18].
Movement of the fifth wheel—Rotation x-axis. Source: Adapted from Saf-Holland [18].
Rotation about the longitudinal axis of up to 3° of movement between the tractor and trailer is permitted. On a standard fifth wheel, this occurs as a result of clearance between the fifth wheel to bracket fit, compression of the rubber bushes, and also the vertical movement between the kingpin and locks may allow some lift of the trailer to one side [18].
\nConsider the third movement of the trailer, the mechanism that represents the fifth wheel has similar design and movements to the suspension mechanism (Figure 15), it is located over the front suspension mechanism.
\nKinematic chain of fifth wheel system.
Here lfw\n is the fifth wheel system’s instantaneous height, FFWn\n is the fifth wheel normal load, and lfi\n is the fifth wheel system’s initial height, b1\n is the fifth wheel width.
\nThe chassis is the backbone of the trailer, and it integrates the main truck component systems such as the axles, suspension, power train, and cab. The chassis is also an important part that contributes to the dynamic performance of the whole vehicle. One of the truck’s important dynamic properties is the torsional stiffness, which causes different lateral load transfers (LLT) on the axles of the vehicle [19].
\nAccording to Winkler [20] and Rill [4], the chassis has significant torsional compliance, which would allow its front and rear parts to roll independently; this is because the lateral load transfer is different on the axles of the vehicle. Then, applying the torsion theory, the vehicle frame has similar behaviour with a statically indeterminate torsional shaft, as shown in Figure 16.
\nKinematic chain of the chassis.
Here TCG\n is the torque applied by the forces acting on the CG, Tf\n (T28\n) is the torque applied on the vehicle front axle, Tr\n (T27\n) is the torque applied on the vehicle rear axle, a is the distance from the front axle to the centre of gravity, and L is the wheelbase of the trailer. Applying torsion theory to the statically indeterminate shaft, the next equation is defined:
\nwhere Jf\n and Jr\n are the equivalent polar moments on front and rear sections of the vehicle frame respectively, and G is the modulus of rigidity (or shear modulus).
\nAccording to Kamnik et al. [21] when a trailer model makes a spiral manoeuvre, the LLT on the rear axle is greater than the LLT on the front axle; therefore the equivalent polar moment on the rear (Jr\n) is greater than the equivalent polar moment on the front (Jf\n). These can be expressed as Jr\n = x Jf\n (where x is the constant that allows controlling the torque distribution of the chassis); replacing and simplifying Eq. (13):
\nHowever, when the trailer model makes a turn, the torque applied on the vehicle front axle has two components, as shown in Figure 17 and Eqs. (15) and (16).
\nTorque components.
where Tfx\n (Tx28\n) is the torque applied in the x-axis (this torque acts on the lateral load transfer on front axle), Tfy\n (Ty28\n) is the torque applied in the y-axis, and \n
Considering the systems developed, the model of the trailer (Figure 18) is composed of the following mechanisms:
the front mechanism of the trailer is composed for the tyres, the suspension, and the fifth wheel,
the rear mechanism is composed for the tyres, and the suspension, and
the last mechanism is the chassis and links the front and rear mechanism of the model.
Trailer model.
The kinematic chain of the trailer model (Figure 18) is composed of 28 joints (j = 28; 14 revolute joints ‘R’, 10 prismatic joints ‘P’, 2 spherical joints ‘S’, 2 spherical slider joints ‘Sd’), and 23 links (n = 23).
\nSeveral methodologies allow us to obtain a complete static analysis of the mechanism. For this purpose, the Davies method was used to analyse the mechanisms statically [11, 22, 23, 24, 25, 26, 27, 28, 29]. This method was selected because it offers a straightforward way to obtain a static model of the mechanism, and this model can be easily adaptable using this approach.
\nIn the majority of LCVs, the load on the trailers is fixed and nominally centred; for this reason, the initial position lateral of the centre of gravity is centred and symmetric.
\nUsually, the national regulation boards establish the maximum load capacity of the axles of LCVs; this is based on the design load capacity of the pavement and bridges, so each country has its regulations. In this scope, the designers develop their products considering that the trailer is loaded uniformly, causing the axle’s load distribution to be in accordance with the laws. Figure 19 shows the example of the normal load distribution.
\nNormal load distribution.
However, some loading does not properly distribute the load, which ultimately changes the centre of gravity of the trailer forwards or backwards, as shown in Figure 20 respectively.
\nLongitudinal CG movement.
In Figures 19 and 20, Ff\n and Fr\n are the forces acting on the front and rear axles respectively.
\nGenerally, the CG position is dependent on the type of cargo, and the load distribution on the trailer and it varies in three directions: longitudinal (x-axis), lateral (y-axis), and vertical (z-axis), as shown Figure 21.
\n\nCG displacements.
Here, d1\n denotes the lateral CG displacement, d2\n denotes the longitudinal CG displacement, and d3\n the vertical CG displacement.
\nFurthermore, Figure 22a and b show that only the weight (W) and the lateral inertial force (may\n) act on the trailer CG, but, when the model takes into account the longitudinal slope angle (φ) and the bank angle (ϕ) of the road, these forces have three components, as represented in Eqs. (17)–(19).
\n(a) Longitudinal slope of the road. (b) Banked road.
where Px\n is the force acting on the x-axis, Py\n is the force acting on the y-axis, and Pz\n is the force acting on the z-axis.
\nFinally, the load distribution of the trailer on a road with a slope angle is given by the Figure 23 and Eq. (20).
\nLoad distribution of a trailer on a road with slope angle.
where h2\n is the instantaneous CG height, L is the wheelbase of the trailer, and a is the distance from the front axle to the centre of gravity.
\nScrew theory enables the representation of the mechanism’s instantaneous position in a coordinate system (successive screw displacement method) and the representation of the forces and moments (wrench), replacing the traditional vector representation. All these fundamentals applied to the mechanism are briefly presented below.
\nIn the kinematic model for a mechanism, the successive screws displacement method is used. Figures 24–28 and Table 1 present the screw parameters of the mechanism.
\nVariables of the mechanism position (model of the front of the trailer).
Variables of the mechanism position (model of the rear of the trailer).
Vector along the direction of the screws axis (model of the front and rear of the trailer).
Variables of the mechanism position (side view of the trailer).
Variables of the mechanism position (three-dimensional model).
Joints and points | \n\ns\n | \n\ns0\n\n | \n\nθ\n | \n\nd\n | \n||||
---|---|---|---|---|---|---|---|---|
Joint 1 | \n1 | \n0 | \n0 | \n\n−l13\n\n | \n0 | \n0 | \n\nθ1\n\n | \n0 | \n
Joint 2 | \n0 | \n0 | \n1 | \n\n−l13\n\n | \n0 | \n0 | \n0 | \n\nl1\n\n | \n
Joint 3a | \n0 | \n1 | \n0 | \n\n−l13\n\n | \n0 | \n0 | \n0 | \n\nt1\n\n | \n
Joint 3b | \n1 | \n0 | \n0 | \n\n−l13\n\n | \n0 | \n0 | \n\nθ3\n\n | \n0 | \n
Joint 4 | \n0 | \n0 | \n1 | \n\n−l13\n\n | \n0 | \n0 | \n0 | \n\nl2\n\n | \n
Joint 5 | \n1 | \n0 | \n0 | \n\n−l13\n\n | \n(t2 − b)/2\n | \n0 | \n\nθ5\n\n | \n0 | \n
Joint 6 | \n0 | \n0 | \n1 | \n\n−l13\n\n | \n(t2 − b)/2\n | \n0 | \n0 | \n\nl3\n\n | \n
Joint 7 | \n1 | \n0 | \n0 | \n\n−l13\n\n | \n(t2 − b)/2\n | \n0 | \n\nθ7\n\n | \n0 | \n
Joint 8 | \n1 | \n0 | \n0 | \n\n−l13\n\n | \n(t2 + b)/2\n | \n0 | \n\nθ8\n\n | \n0 | \n
Joint 9 | \n0 | \n0 | \n1 | \n\n−l13\n\n | \n(t2 + b)/2\n | \n0 | \n0 | \n\nl4\n\n | \n
Joint 10 | \n1 | \n0 | \n0 | \n\n−l13\n\n | \n(t2 + b)/2\n | \n0 | \n\nθ10\n\n | \n0 | \n
Joint 11 | \n1 | \n0 | \n0 | \n0 | \n(t2 − b1\n)/2\n | \n0 | \n\nθ11\n\n | \n0 | \n
Joint 12 | \n0 | \n0 | \n1 | \n0 | \n(t2 − b1\n)/2\n | \n0 | \n0 | \n\nl5\n\n | \n
Joint 13 | \n1 | \n0 | \n0 | \n0 | \n(t2 − b1\n)/2\n | \n0 | \n\nθ13\n\n | \n0 | \n
Joint 14 | \n1 | \n0 | \n0 | \n0 | \n(t2 + b1\n)/2\n | \n0 | \n\nθ14\n\n | \n0 | \n
Joint 15 | \n0 | \n0 | \n1 | \n0 | \n(t2 + b1\n)/2\n | \n0 | \n0 | \n\nl6\n\n | \n
Joint 16 | \n1 | \n0 | \n0 | \n0 | \n(t2 + b1\n)/2\n | \n0 | \n\nθ16\n\n | \n0 | \n
Joint 17 | \n1 | \n0 | \n0 | \n\n−L\n | \n0 | \n0 | \n\nθ17\n\n | \n0 | \n
Joint 18 | \n0 | \n0 | \n1 | \n\n−L\n | \n0 | \n0 | \n0 | \n\nl7\n\n | \n
Joint 19a | \n0 | \n1 | \n0 | \n\n−L\n | \n0 | \n0 | \n0 | \n\nt3\n\n | \n
Joint 19b | \n1 | \n0 | \n0 | \n\n−L\n | \n0 | \n0 | \n\nθ19\n\n | \n0 | \n
Joint 20 | \n0 | \n0 | \n1 | \n\n−L\n | \n0 | \n0 | \n0 | \n\nl8\n\n | \n
Joint 21 | \n1 | \n0 | \n0 | \n\n−L\n | \n(t4 − b)/2\n | \n0 | \n\nθ21\n\n | \n0 | \n
Joint 22 | \n0 | \n0 | \n1 | \n\n−L\n | \n(t4 − b)/2\n | \n0 | \n0 | \n\nl9\n\n | \n
Joint 23 | \n1 | \n0 | \n0 | \n\n−L\n | \n(t4 − b)/2\n | \n0 | \n\nθ23\n\n | \n0 | \n
Joint 24 | \n1 | \n0 | \n0 | \n\n−L\n | \n(t4 + b)/2\n | \n0 | \n\nθ24\n\n | \n0 | \n
Joint 25 | \n0 | \n0 | \n1 | \n\n−L\n | \n(t4 + b)/2\n | \n0 | \n0 | \n\nl10\n\n | \n
Joint 26 | \n1 | \n0 | \n0 | \n\n−L\n | \n(t4 + b)/2\n | \n0 | \n\nθ26\n\n | \n0 | \n
Joint 27 | \n1 | \n0 | \n0 | \n\n−L\n | \n\nt4/2\n | \n\n0\n | \n\nθ27\n\n | \n0 | \n
Joint 28 | \n1 | \n0 | \n0 | \n0 | \n\nt2/2\n | \n0 | \n\nθ28\n\n | \n0 | \n
Point 29 | \n0 | \n0 | \n1 | \n0 | \n\nt2/2\n | \n0 | \n\n\n | \n0 | \n
\nCG (30) | \n1 | \n0 | \n0 | \n\n−a ± d2\n\n | \n\n(t4/2) ± d1\n\n | \n\nl12 ± d3\n\n | \n0 | \n0 | \n
Screw parameters of the mechanism.
In Figures 24–28 and Table 1, l13\n is the distance between the fifth wheel and the front axle, l1;2;7;8\n are the dynamic rolling radii of tyres, t1;3\n are the front and rear track widths of the trailer respectively, t2;4\n are the front and rear axle widths respectively, b is the lateral separation between the springs, b1\n is the fifth wheel width, θi\n is the revolution joint angle rotation i, l3;4;9;10\n are the instantaneous heights of the leaf spring, l12\n is the height of CG above the chassis, and ψ is the trailer/trailer angle.
\nThis method enables the determination of the displacement of the mechanism and the instantaneous position vector s0i\n of the joints, and the centre of gravity (The vector s0i\n (Table 2) is obtained from the first three terms of the last column of equations shown in Table 3).
\nReferences | \n\ns0i\n\n | \n||
---|---|---|---|
1 | \n\n\n | \n\n\n | \n0 | \n
2 | \n\n\n | \n\n\n | \n\n\n | \n
3 | \n\n\n | \n\n\n | \n\n\n | \n
4 | \n\n\n | \n\n\n | \n\n\n | \n
5–16 | \n⁞ | \n⁞ | \n⁞ | \n
17 | \n\n\n | \n0 | \n0 | \n
18 | \n\n\n | \n\n\n | \n\n\n | \n
19 | \n\n\n | \n\n\n | \n\n\n | \n
20 | \n\n\n | \n\n\n | \n\n\n | \n
21 | \n\n\n | \n\n\n | \n\n\n | \n
22–23 | \n\n\n | \n\n\n | \n\n\n | \n
24–28 | \n⁞ | \n⁞ | \n⁞ | \n
\nCG\n | \n\n\n | \n*\n | \n*\n | \n
Instantaneous position vector s0i\n.
\n\n
*\n
*\n
Joints and points | \nInstantaneous position matrix | \n
---|---|
Joint 1 | \n\np’1 = A29 A1 p1\n\n | \n
Joint 2 | \n\np’2 = A29 A1 A2 p2\n\n | \n
Joint 3 | \n\np’3 = A29 A\n\n3a\nA3b p3\n\n | \n
Joint 4 | \n\np’4 = A29 A\n\n3a\nA3b A4 p4\n\n | \n
Joint 5 | \n\np’5 = A29 A1 A2 A5 p5\n\n | \n
Joint 6 | \n\np’6 = A29 A1 A2 A5 A6 p6\n\n | \n
Joint 7 | \n\np’7 = A29 A1 A2 A5 A6 A7 p7\n\n | \n
Joint 8 | \n\np’8 = A29 A1 A2 A8 p8\n\n | \n
Joint 9 | \n\np’9 = A29 A1 A2 A8 A9 p9\n\n | \n
Joint 10 | \n\np’10 = A29 A1 A2 A8 A9 A10 p10\n\n | \n
Joint 11 | \n\np’11 = A29 A1 A2 A5 A6 A7 A11 p11\n\n | \n
Joint 12 | \n\np’12 = A29 A1 A2 A5 A6 A7 A11 A12 p12\n\n | \n
Joint 13 | \n\np’13 = A29 A1 A2 A5 A6 A7 A11 A12 A13 p13\n\n | \n
Joint 14 | \n\np’14 = A29 A1 A2 A5 A6 A7 A14 p14\n\n | \n
Joint 15 | \n\np’15 = A29 A1 A2 A5 A6 A7 A14 A15 p15\n\n | \n
Joint 16 | \n\np’16 = A29 A1 A2 A5 A6 A7 A14 A15 A16 p16\n\n | \n
Joint 17 | \n\np’17 = A17 p17\n\n | \n
Joint 18 | \n\np’18 = A17 A18 p18\n\n | \n
Joint 19 | \n\np’19 = A\n\n19a\nA19b p19\n\n | \n
Joint 20 | \n\np’20 = A\n\n19a\nA19b A20 p20\n\n | \n
Joint 21 | \n\np’21 = A17 A18 A21 p21\n\n | \n
Joint 22 | \n\np’22 = A17 A18 A21 A22 p22\n\n | \n
Joint 23 | \n\np’23 = A17 A18 A21 A22 A23 p23\n\n | \n
Joint 24 | \n\np’24 = A17 A18 A24 p24\n\n | \n
Joint 25 | \n\np’25 = A17 A18 A24 A25 p25\n\n | \n
Joint 26 | \n\np’26 = A17 A18 A24 A25 A26 p26\n\n | \n
Joint 27 | \n\np’27 = A17 A18 A21 A22 A23 A27 p27\n\n | \n
Joint 28 | \n\np’28 = A29 A1 A2 A5 A6 A7 A11 A12 A13 A28 p28\n\n | \n
\nCG (30) | \n\np’CG = A17 A18 A21 A22 A23 A27 ACG pCG\n\n | \n
Instantaneous position matrix.
In the static analysis, all forces and moments of the mechanism are represented by wrenches ($A\n) [13]. The wrenches applied can be represented by the vector $A\n = [Mx My Mz Fx Fy Fz\n]\nT\n, where F denotes the forces, and M denotes the moments.
\nTo simplify the model of Figure 28, the following considerations were made:
for the x-direction a steady-state model was used in the analysis;
disturbances imposed by the road and the lateral friction forces (Fy\n) (tyre-ground contact) in the joints 3 and 19 were neglected; and
the components of the trailer weight (W) and the inertial force (may\n) are the only external forces acting on the trailer CG.
Considering a static analysis in a three-dimensional space [7], the corresponding wrenches of each joint and external forces are defined by the parameters of Table 4, where si\n represents the orientation vector of each wrench i.
\nJoints and reference points | \nConstraints and forces | \n\nsi\n\n | \nInst. position vector s0i\n\n | \n||
---|---|---|---|---|---|
Revolute joints 1, 7, 8, 10, 13, 14, 16, 17, 23, 24, and 26 | \n\nFxi\n\n | \n1 | \n0 | \n0 | \nRevolute joints 1, 7, 8, 10, 13, 14, 16, 17, 23, 24, and 26 | \n
\nFyi\n\n | \n0 | \n1 | \n0 | \n||
\nFzi\n\n | \n0 | \n0 | \n1 | \n||
\nMyi\n\n | \n0 | \n1 | \n0 | \n||
\nMzi\n\n | \n0 | \n0 | \n1 | \n||
Spherical slider joints 3 and 19 | \n\nFxi\n\n | \n1 | \n0 | \n0 | \nSpherical slider joints 3 and 19 | \n
\nFzi\n\n | \n0 | \n0 | \n1 | \n||
Revolute joints 5, 11, and 21 | \n\nFxi\n\n | \n1 | \n0 | \n0 | \nRevolute joints 5, 11, and 21 | \n
\nFyi\n\n | \n0 | \n1 | \n0 | \n||
\nFzi\n\n | \n0 | \n0 | \n1 | \n||
\nTxi\n\n | \n1 | \n0 | \n0 | \n||
\nMyi\n\n | \n0 | \n1 | \n0 | \n||
\nMzi\n\n | \n0 | \n0 | \n1 | \n||
Prismatic joints 2, 4, 6, 9, 12, 15, 18, 20, 22 and 25 | \n\nFxi\n\n | \n1 | \n0 | \n0 | \nPrismatic joints 2, 4, 6, 9, 12, 15, 18, 20, 22, and 25 | \n
\nFni\n\n | \n0 | \n\ncos θi−1\n\n | \n\nsin θi−1\n\n | \n||
\nMxi\n\n | \n1 | \n0 | \n0 | \n||
\nMyi\n\n | \n0 | \n1 | \n0 | \n||
\nMzi\n\n | \n0 | \n0 | \n1 | \n||
Prismatic joints 2, 4, 18, and 20 | \n\nFTi\n\n | \n0 | \n\n−sin θi−1\n\n | \n\ncos θi−1\n\n | \nPrismatic joints 2, 4, 18, and 20 | \n
Prismatic joints 6, 9, 22, and 25 | \n\nFLSi\n\n | \n0 | \n\n−sin θi−1\n\n | \n\ncos θi−1\n\n | \nPrismatic joints 6, 9, 22, and 25 | \n
Prismatic joints 12 and 15 | \n\nFFWi\n\n | \n0 | \n\n−sin θi−1\n\n | \n\ncos θi−1\n\n | \nPrismatic joints 12 and 15 | \n
Spherical joints 27 and 28 | \n\nFxi\n\n | \n1 | \n0 | \n0 | \nSpherical joints 27 and 28 | \n
\nFyi\n\n | \n0 | \n1 | \n0 | \n||
\nFzi\n\n | \n0 | \n0 | \n1 | \n||
\nTxi\n\n | \n1 | \n0 | \n0 | \n||
\nCG (30) | \n\nPx\n\n | \n1 | \n0 | \n0 | \n\nCG (30) | \n
\nPy\n\n | \n0 | \n\n−1 | \n0 | \n||
\nPz\n\n | \n0 | \n0 | \n\n−1 | \n
Wrench parameters of the mechanism.
All of the wrenches of the mechanism together comprise the action matrix [Ad\n] given by Eq. (21) (or the amplified matrix of the Eq. (22)).
\nwhere pi\n is a system variable.
\nThe wrench can be represented by a normalised wrench and a magnitude. Therefore, from the Eq. (22) the unit action matrix and the magnitudes action vector are obtained, as represented by Eqs. (23) and (24).
\nKinematic chains and mechanisms are comprised of links and joints, which can be represented by graphs, where the vertices correspond to the links, and the edges correspond to the joints and external forces [5, 7].
\nThe mechanism of the Figure 28 is represented by the direct coupling graph of the Figure 29. This graph has 23 vertices (links) and 31 edges (joints and external forces (Px\n, Py\n, and Pz\n)).
\nDirect coupling graph of the mechanism.
The direct coupling graph (Figure 29) can be represented by the incidence matrix [I]\n23X31\n [30] (Eq. (25)). The incidence matrix provides the mechanism cut-set matrix [Q]\n22X31\n [11, 25, 26, 27, 28, 30] (Eq. (26)) for the mechanism, where each line represents a cut graph and the columns represent the mechanism joints. Besides, this matrix is rearranged, allowing 22 branches (edges 1–3, 5–9, 11–15, 17–19, 21–25, and 27—identity matrix) and 9 chords (edges 4, 10, 16, 20, 26, 28, Px, Py,\n and Pz\n) to be defined, as shown in Figure 30.
\nCut-set action graph of the mechanism.
All constraints are represented as edges, which allows the amplification of the cut-set graph and the cut-set matrix. Additionally, the tyre normal load (FTi\n), spring normal load (FLSi\n), fifth wheel normal load (FFWi\n), and the passive torsional moment (Txi\n) are included.
\n\nFigure 30 presents the cut-set action graph and the Eq. (27) presents the expanded cut-set matrix ([Q]\n22X148\n), where each line represents a cut of the graph, and the columns are the constraints of the joints as well as external forces on the mechanism.
\nUsing the cut-set law [24], the algebraic sum of the normalised wrenches given in Eqs. (23) and (24), that belong to the same cut [Q]\n22X148\n (Figure 30 and Eq. (27)) must be equal to zero. Thus, the statics of the mechanism can be defined, as exemplified in Eq. (28) (or the amplified matrix of the Eq. (29)):
\nIt is necessary to identify the set of primary variables [Ψ\np\n] (known variables), among the variables of Ψ. Once identified, the system of the Eq. (28) is rearranged and divided in two sets, as shown by Eq. (30).
\nwhere [Ψ\np\n] is the primary variable vector, [Ψ\ns\n] is the second variable vector (unknown variables), \n
In this case, the primary variable vector is:
\nand the secondary variable vector is:
\nSolving the system Eq. (30) using the Gauss-Jordan elimination method, all secondary variables being function of the primary variables, the last row of the solution system provides the next equation:
\nreplacing Py\n and Pz\n:
\nwhere P1\n is a system variable (\n
According to the static redundancy problem known as the four-legged table [31, 32], a plane is defined by just three points in space and, consequently, a four-legged table has support plane multiplicities. This is why when one leg loses contact with the ground, the table is supported by the other three, as shown in Figure 31.
\nRedundancy problem of the four-legged table.
The problem of the four-legged table is observed in dynamic rollover tests when the rear inner tyre loses contact with the ground (Fz19 = 0), and the front inner tyre (Fz3\n) does not, as shown, for example, in Figure 32.
\nDynamic rollover test. Source: Adapted of Cabral [33].
Applying this theory to the vehicle stability, when a vehicle makes a turn, it is subjected to an increasing lateral load until it reaches the rollover threshold [32]. During the turning, the rear inner tyre is usually the one that loses contact with the ground. For this condition (Fz19 = 0), and thus:
\nwhere \n
The normal forces Fz3\n and Fz17\n depend on the LLT coefficient in the front and rear axles respectively [4, 21, 34]. Furthermore, this coefficient depends on the vehicle type, speed, suspension, tyres, etc.
\nThis information demonstrates that the \n
where h is the CG height, t is the vehicle track.
\nWith Eq. (36), it is possible to obtain a better vehicle stability representation and the \n
To simplify the solution of the system of equations in Eq. (30), the following hypotheses were considered:
in the majority of LCVs, the load on the trailers is uniformly distributed (Eq. (20));
the lateral load transfer of the trailer model is controlled through the torsional moment of the chassis (spherical joints 27 and 28 (Eqs. (15) and (16))).
\nEq. (38) shows the final static system for the stability analysis, solving this system using the Gauss-Jordan elimination method, all secondary variables are a function of primary variables, (Px\n—force acting on the x-axis, Py\n—force acting on the y-axis, and Pz\n—force acting on the z-axis).
\nIn this study, a B-train trailer with two axles on front and three axles on the rear is analysed. This model has a suspension system with a tandem axle, and its parameters depend on the construction materials. Another important parameter of the model is the dynamic rolling radius or loaded radius li\n. The proposed model considers Michelin XZA® [36] radial tyres. Table 5 shows the parameters of the trailer used in this analysis [32, 38].
\nParameters of the trailer | \nValue | \nUnits | \n
---|---|---|
Trailer weight—W\n | \n355.22 | \nkN | \n
Front and rear track widths (t1,3\n) | \n1.86 | \nm | \n
Front and rear axles widths (t2,4\n) | \n1.86 | \nm | \n
Stiffness of the suspension per axle (ks\n) [37] | \n1800 | \nkN.m−1\n | \n
Number of axles at the front (trailer) (four tyres per axle) | \n2 | \n\n |
Number of axles at the rear (trailer) (four tyres per axle) | \n3 | \n\n |
Vertical stiffness per tyre (kT\n) ([37]) | \n840 | \nkN.m−1\n | \n
Initial suspension height (l3,4,9,10\n) (ls\n) | \n0.205 | \nm | \n
Initial dynamic rolling radius (l1,2,7,8\n) (lr\n) (Michelin XZA® [36]) | \n0.499 | \nm | \n
Initial height of the fifth wheel (lfi\n) | \n0.1 | \nm | \n
Lateral separation between the springs (b) | \n0.95 | \nm | \n
Fifth wheel width (b1\n) | \n0.6 | \nm | \n
\nCG height above the chassis (l12\n) | \n1.346 | \nm | \n
Distance between the fifth wheel and the front axle (l13\n) | \n0.15 | \nm | \n
Wheelbase of the trailer (L) | \n4.26 | \nm | \n
Distance from the front axle to the centre of gravity (a) | \n3 | \nm | \n
Offset of the cargo d1\n\n | \n0.1 | \nm | \n
Trailer/trailer angle (ψ) | \n0 | \n° | \n
Parameters of the trailer model.
To calculate the SRT factor, the inertial force is increased until the lateral load transfer in the rear axle is complete (the entire load is transferred from the rear inner tyre to the rear outer tyre when the model makes a turn). The reduction in the SRT factor (Eq. (36) and the solution of the system of Eq. (38)) results from the combined action of the trailer systems, which allows a body roll angle of the trailer model (Figure 33) [32]. In this figure, it can be seen how the stability factor varies according to the influence of some of the parameters of the developed model.
\n(a) Roll angle of the trailer (θ). (b) Change in the SRT factor.
When the model considers all parameters, the LLT coefficient on the front axle is approximately 70% of the LLT coefficient on the rear axle [21]. Applying this concept, the SRTall\n factor reduces to 0.3364 g. Finally, the proposed model shows how the lateral offset of the cargo (d1\n = 0.1 m) influences the SRToff\n factor: 2 cm of lateral offset corresponds to a loss of stability of around 0.01 g a reduction similar to that reported by Winkler [20, 32].
\nAdditionally, the proposed model shows how a change in the lateral separation between the springs (b) influences the SRT factor. Some LCVs with tanker trailers have a greater lateral separation between the springs, which leads to a decrease in the roll angle and thus an increase in the SRT factor: 1 cm of lateral separation between the springs corresponds to a gain or loss of stability of around 0.001 g, as shown in Figure 33b [32].
\nThis model also allows the determination of the lateral (h1\n) and vertical (h2\n) CG location (Figure 34).
\nFinally, if we consider the recommended maximum lateral load transfer ratio for the rear axle of 0.6 [39, 40], and also include the recommended bank angle and longitudinal slope of the road [41, 42], we can calculate the SRT factor for a trailer model on downhill and uphill corners. Table 6 shows a trailer model with different trailer/trailer angles (ψ) [32].
\n(a) Lateral CG location. (b) Vertical CG location.
Slope angle (φ)-(%) | \nUphill corners | \n\n | Downhill corners | \n|||||||
---|---|---|---|---|---|---|---|---|---|---|
Trailer/trailer angle (\n | \nBank angle (\n | \n8 | \n6 | \n4 | \n2 | \n0 | \n2 | \n4 | \n6 | \n8 | \n
0 | \n0 | \n0.240 | \n0.223 | \n0.214 | \n0.208 | \n0.202 | \n0.198 | \n0.194 | \n0.190 | \n0.186 | \n
0 | \n2 | \n0.261 | \n0.245 | \n0.235 | \n0.228 | \n0.223 | \n0.218 | \n0.214 | \n0.210 | \n0.206 | \n
0 | \n4 | \n0.283 | \n0.265 | \n0.256 | \n0.249 | \n0.244 | \n0.239 | \n0.234 | \n0.230 | \n0.226 | \n
0 | \n6 | \n0.305 | \n0.286 | \n0.277 | \n0.270 | \n0.265 | \n0.260 | \n0.256 | \n0.252 | \n0.248 | \n
0 | \n8 | \n0.327 | \n0.308 | \n0.299 | \n0.292 | \n0.285 | \n0.281 | \n0.276 | \n0.272 | \n0.268 | \n
0 | \n10 | \n0.350 | \n0.330 | \n0.320 | \n0.313 | \n0.307 | \n0.303 | \n0.298 | \n0.294 | \n0.290 | \n
10 | \n0 | \n0.241 | \n0.223 | \n0.214 | \n0.207 | \n0.202 | \n0.197 | \n0.193 | \n0.189 | \n0.185 | \n
10 | \n2 | \n0.262 | \n0.245 | \n0.234 | \n0.227 | \n0.222 | \n0.217 | \n0.213 | \n0.209 | \n0.205 | \n
10 | \n4 | \n0.283 | \n0.265 | \n0.256 | \n0.249 | \n0.243 | \n0.239 | \n0.233 | \n0.229 | \n0.225 | \n
10 | \n6 | \n0.306 | \n0.286 | \n0.276 | \n0.270 | \n0.264 | \n0.259 | \n0.255 | \n0.251 | \n0.247 | \n
10 | \n8 | \n0.328 | \n0.308 | \n0.298 | \n0.291 | \n0.285 | \n0.280 | \n0.276 | \n0.271 | \n0.267 | \n
10 | \n10 | \n0.351 | \n0.330 | \n0.319 | \n0.312 | \n0.307 | \n0.302 | \n0.297 | \n0.293 | \n0.288 | \n
20 | \n0 | \n0.241 | \n0.222 | \n0.212 | \n0.206 | \n0.200 | \n0.195 | \n0.191 | \n0.187 | \n0.182 | \n
20 | \n2 | \n0.262 | \n0.244 | \n0.233 | \n0.226 | \n0.220 | \n0.216 | \n0.211 | \n0.207 | \n0.203 | \n
20 | \n4 | \n0.283 | \n0.264 | \n0.254 | \n0.247 | \n0.242 | \n0.236 | \n0.232 | \n0.227 | \n0.224 | \n
20 | \n6 | \n0.306 | \n0.285 | \n0.275 | \n0.268 | \n0.262 | \n0.257 | \n0.253 | \n0.249 | \n0.245 | \n
20 | \n8 | \n0.328 | \n0.307 | \n0.297 | \n0.290 | \n0.283 | \n0.278 | \n0.274 | \n0.270 | \n0.265 | \n
20 | \n10 | \n0.351 | \n0.329 | \n0.318 | \n0.311 | \n0.305 | \n0.300 | \n0.295 | \n0.291 | \n0.286 | \n
Static rollover threshold (SRT) of the trailer model with trailer/trailer angle.
In the worst-case scenario, the trailer model, for a downhill corner with a bank angle of 0%, the longitudinal slope of the road of 8%, and a trailer/trailer angle of 20° can reduce the SRT factor of the model by 59.6%, using 0.4511 g as a reference [32].
\nAn analysis of Table 6 leads to the following conclusions for the critical conditions of the trailer:
a 1% bank angle corresponds to gain in the stability of around 0.01 g;
when the trailer is in downhill corners, a 1% slope angle corresponds to a loss of stability of around 0.0021 g;
the trailer/trailer angle is inversely proportional to the SRT factor since when the trailer makes a horizontal curve with a small radio, and the trailer/trailer angle and inertial force are large, the SRT factor is lower.
This study demonstrates that the longitudinal characteristics of a trailer model have an essential influence on the SRT factor calculation. In this case, the SRT factor is approximately 38% lower than the previously reported standard value. This value is very close to that reported by Winkler [20] (i.e. 40%), which suggests that the proposed model provides consistent results [32].
\nThis model also shows that the change in the lateral separation between the springs (b) plays an important role, and thus it should be considered in the design and construction of trailers. Greater lateral separation between the springs will increase the trailer model stability [32].
\nWe also found that the parameters of the road, such as the bank angle and the longitudinal slope angle, can affect vehicle stability. This situation is closer to the actual problem: when the road is not planar, the lateral and the longitudinal load transfer play an important role in reducing the stability. On the other hand, this provides a very important warning, because some simplifications carried out when estimating the SRT factor can lead to a considerably higher stability value. This is a point of concern, leading to the perception that our roads are safer than they really are [32].
\nCarbon materials can be grouped into three classifications based on their period of advancement: classical carbons, nano ones and new carbons. Cracking carbons incorporate engineered graphite squares principally utilized as anodes, carbon blacks, what are more, enacted carbons, for which creation systems were created before [1] the 1960s. During the 1960s, carbon materials not quite the same as these great carbons were designed: carbon filaments from different forerunners, including fume developed carbon filaments; pyrolytic carbons delivered by means of concoction fume testimony forms; glasslike carbons with high hardness and gas impermeability; high-thickness isotropic carbons created by isostatic squeezing; intercalation mixes with various functionalities, for example, high electrical conductivity; and precious stone like carbons as straightforward carbon sheets. These recently evolved carbon materials are grouped as new carbons [2]. Since the 1990s, different fullerenes with shut shell structure, carbon nanotubes with nanometer distances across, and graphene pieces of just a couple molecules’ thickness has stood out from nanotechnology; these are ordered as nanocarbons.
On the off chance that these carbon materials are considered from the perspective of their surface, be that as it may, they might be ordered into two gatherings: nano-textured and nano-sized carbons [3]. Most carbon materials in the new carbon classification are delegated nano-textured carbon, in light of the fact that their nano texture is controlled by means of various procedures in their creation, notwithstanding the basic control. Then again, fullerenes, carbon nanotubes, and graphene can be delegated nano-sized carbon, the shell size of fullerenes, breadth of carbon nanotubes, and thickness of graphene, drops are on the nanometer scale [4]. Carbon blacks in great carbon are made out of nano-sized particles, yet they are not typically named nanocarbons since they have different applications as a mass, not as individual nano-sized particles [5].
Carbon, a basic chemical substance containing 6 as atomic number with 6 electrons tend to occupy s and p orbitals. It can able to undergo hybridization through three different forms such as sp/sp2 or sp3 means. Recent inventions of compact structured carbon materials such as fullerene [6], graphene [7], and carbon nanotubes [8] have envisaged prompt enquiries into this emerging field. Various physical properties of carbon nanotubes were mostly derived from base material (graphene). Such graphene involves the dense packing arrangement of carbon atoms in a regular sp2 pattern bonded to honeycomb based atomic scale structure and especially this pattern is most suitable as a primary structure for other sp2 materials [9]. Based on theoretical judgment, this CNT is explicitly distinct in the cylinder form fabricated of swirled up graphene thick sheet, which can delineate itself to single or multiple well. The single well nanotubes were known as single walled carbon tubes which were investigated during 1993 whereas multi-walled ones were found during 1991 itself [10].
CNTs have outstanding mechanical, thermal, electrical, and optical properties that are being used exclusively or in mix to deliver keen sensors or on the other hand multifunctional materials [11, 12]. They have high angle proportions that are perfect for long and persistent detecting. Their high surface region, for example, can be misused for storing materials to make half breed useful materials or functionalized to make cathodes for an assortment of uses [13]. CNTs are additionally known to display ballistic conductivity because of insignificant electron dispersing in their 1D structure with mean free-ways of the request of several microns [14, 15].
Mechanical strain may cause reproducible changes in the electrical properties of CNT filaments, making it conceivable to misuse them as electromechanical sensors [16, 17]. The partner changes incorporate inductance, capacitance, and obstruction which can be associated to the strain. Of incredible significance is that CNT filaments are receptive to elastic, compressive, flexural, and torsional strain [18].
The working standards of sensors produced using a CNT plainly visible get together incorporate difference in their electrical resistivity or obstruction because of mechanical strain known as piezoresistivity, change of their inductance and capacitance because of mechanical strain, change of their electrical resistivity because of variety in temperature known as thermoresistivity [19], change of their electrical obstruction because of variety in an attractive field known as magnetoresistance [20], and change in their electrical opposition with change of their mechanical thunderous recurrence because of variety of temperature, weight, mass, and strain [11]. The adjustment in conductance or obstruction is substantially more predominant than other variety in electrical properties. This is somewhat in light of the fact that charge transporters are handily isolated under simultaneous deformation prompting an expansion in obstruction. For extremely little strains, the total deformation has demonstrated to be flexible and the conductive system is completely recouped when the strain is evacuated, prompting an abatement in opposition [21]. Thus, the presented chapter highlights the synthesis details, associated properties and current applications of carbon nanotubes.
There are many methods to synthesize CNTs, but these three methods are most important and commonly used methods. They are as follows.
Chemical vapor deposition (CVD): CVD is a technique in which the vaporized reactants react chemically and forms a nanomaterial product that is deposited on the substrate Figure 1.
CVD method.
Sources for carbon: The precursor for carbon nanotubes are hydrocarbon gases such as acetylene, ethylene, methane, etc. [22].
Substrate used: Substrates are materials on which the CNTS are grown. The commonly used substrates in CVD method are zeolite, silica, silicon plate coated with iron particles, etc.
Catalyst used: To produce single-walled carbon nanotubes metal catalyst nanoparticles such as iron, cobalt, nickel, molybdenum, iron-molybdenum alloys, etc. are used.
Sources for CVD used: Based on the heating source, the CVD can be:
Thermal activated CVD which is heated by IR radiation, RF heater, etc.
Photo assisted CVD which is heated by Arc lamps, CO2 laser, Argon ion laser, Nd:YAG laser, etc.
Plasma assisted CVD which is heated by microwave radiation, etc.
Conditions maintained: The following conditions are maintained inside the furnace.
Temperature: 500–900°C.
Inert gas atmosphere: Argon gas.
CNTs are synthesized by thermal CVD method by using hydrocarbon gas as carbon source. In this method, a quartz tube is placed inside a furnace maintained at high temperature (500–900°C) heated by RF heater. A crucible containing the substrate coated with catalyst nanoparticles is placed inside quartz tube filled with inert gas such as argon gas. The hydrocarbon gas (carbon source) is pumped into the quartz tube which undergoes pyrolysis reaction and forms vapor carbon atoms. These carbon atoms bind to the substrate and join to eachother by Vanderwaal force of attraction and grow as multi-walled carbon nanotubes (MWCNTs) on the substrate [23]. To synthesize single-walled carbon nanotubes catalyst nanoparticles of Fe, Co, Ni are used. The obtained CNTs are further purified to get the pure form of CNTs.
Carbon nanotubes are synthesized by electric arc discharge method which is also called Plasma Arcing method.
Electrodes: Pure graphite rods (both positive and negative electrode). The positive electrode is adjustable from outside to maintain the gap between the two electrodes.
Diameter of electrodes: 5–20 μm.
Gap between electrodes: 1 mm.
Current: 50–120 amperes.
Voltage: 20–25 V.
Inert gas pressure: 100–500 torr (No CNT formed below 100 torr). Inert gas is used for cooling and condensation of atoms to form the CNTs. Inert gas determines the structure of carbons to be present in CNTS. Commonly used inert gas is helium gas.
Temperature: 3000–3500°C.
Reactor: It contains a quartz chamber which is connected to vacuum pump and a diffusion pump to inert gas supply. Initially the chamber is made vacuum by the vacuum pump and then the chamber is filled with helium gas by the diffusion pump [24].
In this method, a potential of 20–25 V is applied across the pure graphite electrodes separated by 1 mm distance and maintained at 500 torr pressure of flowing helium gas filled inside the quartz chamber Figure 2. When the electrodes are made to strike each other under these conditions it produces an electric arc. The energy produced in the arc is transferred to the anode which ionizes the carbon atoms of pure graphite anode and produces C+ ions and forms plasma (Plasma is atoms or molecules in vapor state at high temperature). These positively charged carbon ions moves towards cathode, gets reduced and deposited and grow as CNTs on the cathode. As the CNTs grow, the length of the anode decreases, but the electrodes are adjusted and always maintain a gap of 1 mm between the two electrodes. If proper cooling of electrodes are achieved uniform deposition of CNTs are formed on the cathode which is achieved by inert gas maintained at proper pressure [25]. By this method multi-walled carbon nanotubes are synthesized and to synthesize single-walled carbon nanotubes catalyst nanoparticles of Fe, Co, and Ni are incorporated in the central portion of the positive electrode. The obtained CNTs are further purified to get the pure form of CNTs.
Electric arc method.
Physical vapor deposition (PVD): PVD is a technique by which a material can be vaporized into gaseous form and then deposited on the surface of a substrate.
Target source: The most common carbon source target used is solid graphite which is irradiated by laser source and vaporized into vapor carbon atoms.
Laser source: Laser source used for vaporization of target material into target vapor atoms can be continuous laser source such as CO2 laser or pulsed laser source such as Nd:YAG laser (Neodymium doped Yttrium Aluminum Garnet, Nd:Y3Al5O12) .
Substrate used: The substrate used in this method is the water cooled copper collector on which the vaporized carbon atoms deposit and grow as CNTs.
Inert gas atmosphere: Argon gas is commonly used as inert gas which flows at a constant flow rate towards the water cooled copper collector.
Laser Ablation method is a Physical Vapor Deposition method in which graphite target is vaporized by laser source Figure 3. In this method the graphite target is placed at the center of quartz chamber filled with argon gas and maintained at 1200°C. The graphite target is vaporized by either continuous laser source or pulsed laser source. The vaporized target atoms (carbon) are sweeped toward cooled copper collector by the flow of argon gas. The carbon atoms are deposited and grown as CNTs on cooled copper collector. In case of continuous laser beam, the carbon atoms are continuously vaporized whereas in case of pulsed laser beam the amount of CNTs produced can be monitored as each shot of pulsed laser beam is directly proportional to the amount of carbon atoms vaporized [26]. By this method multi-walled carbon nanotubes are synthesized and to synthesize single-walled carbon nanotubes catalyst nanoparticles of Fe, Co, Ni are used. The obtained CNTs are further purified to get the pure form of CNTs.
Laser ablation method—schematic representation.
Pulsed Laser deposition is a thin film deposition technique in which the target material is vaporized by pulsed laser beam and vaporized target atoms are made to deposit on substrates Figure 4. The furnace contains a target at bottom and substrate mounted on the top. A pulsed laser beam from Nd:YAG laser source is made to strike the target to produce vaporized target atoms called the plume (plume is vaporized atoms at high temperature) [27]. The plume moves towards the substrate and it is deposited and grown as CNTs. Each shot of laser is directly related to the amount of material ablated, thus deposition rate can be controlled and calibrated.
Pulsed laser ablation method—Schematic representation.
The synthesized CNTs can be separated from the amorphous carbon, carbon nanoparticles, residual catalyst and other impurities by various methods. The conventional methods of purification are not very successful but methods like gas phase, liquid phase and intercalation methods show good results.
Gas phase purification of CNTs: In this method the CNTs are subjected to a high temperature oxidation followed by repeated extractions with nitric acid and hydrochloric acid. This procedure makes the synthesized CNTs purer and high stability with fewer amounts of residual catalyst and other non CNTs forms.
Liquid phase purification of CNTs: A series of steps are followed in the liquid phase purification of synthesized CNTs. They are:
Preliminary filtration to remove bulk graphite particles.
Dissolution in both organic solvents and concentrated acids to remove the fullerenes and catalyst, respectively.
Centrifugal separation of CNTs (Solid part) from the solution (containing impurities).
Microfiltration.
Chromatography to isolate multi-walled carbon nanotubes, single-walled carbon nanotubes, etc.
Intercalation purification of CNTs: In this method the nanoparticle impurities present are oxidized by metallic copper which acts as oxidation catalyst formed from the reduction of copper chloride added during the process. This process introduces intercalate residues and damage CNTs during oxidation process.
There are numerous mechanisms available to build up structures occluded with various characteristics. The sp2 nature of carbon hybridization constructs a layered pattern of arrangement with weaker plane bonding of Vander Waals forces at the outside and strong forces at inner plane bounds. Few numbers of concentric cylinders were equipped with regular spacing of interlayers that are located around central hollow section and demonstrated as multi walled CNTs Figure 5. In general, the real time spacing of MWCNTs contain interlayer spacing in range of 0.35–0.40 nm. The inner diameter of multi-walled CNTs can even range from 0.40 nm to few nanometers [28]. Outer diameter can exist up to 25 nm. The tips on both sides were closed and protruding ends were capped using dome shaped half width fullerene molecules. Axial molecules can exist up to few centimeters. The primary function of half width fullerene molecules is to aid in shutting down the tubes at both the ends. Whereas SWCNT can exist up to 4 nm. Length is up to micrometer range. Such arrangement is organized in a hexagon shape so as to develop a crystal [29].
Graphene to CNT.
Based on wrapping mechanism, three different forms of SWCNTs include chiral, armchair, and zigzag pattern. The single walled structure is primarily characterized by a set of indices (n and m) which describes the vector mechanism of chiral and absolutely it impinges an impact on electrical tendency of both nanotubes Figure 6. As a general predict, when n = m, these nanotubes are known as armchair ones and if m = 0, they are said to be zigzag and for other range as chiral pattern [30].
Different forms of SWCNTs.
The vector value of chiral mechanism can be determined using C = na1 + ma2, where a1 and a2 represent the base vectors of graphite cell and also used to evaluate the tube radius and moreover this vector function also estimates the rolling direction of graphene sheet. Hence, the radius of carbon nanotube can be estimated using.
where a takes the lattice parameter in graphite sheet.
Whenever n − m = 3 times of any value, it indicates the carbon nanotube to be metallic or extremely conducting nature and if it is not so, it can be semi-metallic type or a semi-conductor. At most of the times, armchair type can be referred as metallic one whereas all other forms can be denoted as a semi-conductor. Various involved parameters and vector representations [31] can provide an impinging impact on structure of CNT as follows.
chiral vector = na1 + na2> > (n,m)
Translational vector, T = t1a1 + t2a2 > > (t1, t2)
Chiral vector length, L = a(n2 + n.m + m2)1/2 a is constant of lattice parameter.
angle of chiral vector = (2n + m)/2*(n2 + n.m + m2)1/2
radius = L/2∏
Rotation angle, ᴪ = 2∏/N
vector of symmetry, R = pa1 + qa2
Such MWCNTs can be developed via two distinct models such as Russian doll and Parchment type model. If the diameter of outer CNT exceeds the inner tube, such a model is prescribed as Russian type model whereas, wrapping of a single graphite sheet to many a fold around itself constitutes the simple Parchment model. Both multi walled and single walled CNTs possess similar properties. Due to multi-layered arrangement of multi walled nanotubes, the outer portion not only cover the inner tubes from certain chemical reactions when contaminate with ambient substances but also exhibit greater tensile characteristics, which would be a drawback of single walled CNTs [32].
Owing to the presence of sp2 bonds available betwixt indigenous carbon atoms, CNTs possess higher tensile property compared to steel as well as Kevlar. such a bond exhibits more strength rather than sp3 bonding of diamond. Hence, SWCNTs possess maximum tensile property which may be nearly 100 times as that of steel [33].
An amazing feature of CNTs is its elasticity. Under maximum force and high pressure by exposing it to greater compressive forces along axial direction, it can even bend, kink, twist and ultimately buckle without causing any damage to CNT. Thus nanocarbon tubes can retain its original geometric structure. But sometimes, elasticity tends to cope up with a limit and hence under the influence of stronger physical pressure forces, it can even undergo a temporary deformation to form the nanotube shape. Few defects may weaken its structure which includes the atomic defects or else rearrangement developed on the carbon bonds.
The elasticity property for both single walled and multi walled CNTs is examined by the term known as modulus of elasticity or elastic modulus. Such property of multi-walled CNTs can be analyzed using transmission electron microscopy (TEM). Using such an apparatus, the researchers examine and investigate the molecular vibrations owing to thermal forces created at both edges of tubes [34].
As the atomic bond strength is high, CNTs not only withstand elevated temperature levels but also act as excellent thermal conductors. Hence under vacuum atmospheric pressure ranges, they are able to withstand 2900°C and nearly 800°C at normal pressure conditions. But the prevailing tube temperature and ambient environment may have an impact on thermal conductivity of carbon nanotubes [35]. The prescribed physical properties were outlined in Table 1.
Physical properties | Parameter | Range | References |
---|---|---|---|
Structure during equilibrium | Mean diameter | 1.3–1.5 nm | [31] |
Density | Zig zag (16,0) | 1.33 g/cm3 | [30] |
Armchair (10,9) | 1.32 g/cm3 | [30] | |
Chiral (12,5) | 1.41 g/cm3 | [32] | |
Lattice parameter | Zig zag (16,0) | 16.53 nm | [32] |
Chiral (12,5) | 16.53 nm | [33] | |
Arm chair (10,9) | 16.55 nm | [32] | |
Interlayer distance | Zig zag | 3.40 Å | [33] |
Chiral | 3.38 Å | [33] | |
Arm chair | 3.37 Å | [34] | |
Elastic nature | Young’s modulus | 1.0–1.27 TPa | [35] |
Tensile strength | About 100 GPa | [35] | |
Thermal property | Mean free path | Around 100 nm | [36] |
Thermal conductivity | Around 2000 W/m-K | [37] | |
Electrical behavior | Current density | 1015 A/m2 | [38] |
Conductance | 13.0 (K.Ohms)−1 | [38] |
Physical properties of CNTs.
Various types of indigenous single walled CNTs obtained using chemical vapor deposition technique onto a supporting chemical agent are mostly of semi-conducting nature (I type). Such nanotube type depicts the impact of field transistor (FET) nature at atmospheric conditions and these have been recently attaining greater interest and also achieved extensive exploration towards their application as nanoelectronic materials indulging logic circuit devices and electronic transistors. Such growing CNTs are seemed to be p-type containing doped holes with absolute hole depletion and reduced conductance values (100 kΩ to 1 MΩ) in specific to positive logic gate voltages. in the present context, it has been demonstrated that adsorption of molecular oxygen onto the CNTs is a contributing factor do drive the hole doping effect of SWCNTs. Oxygen removal can even lead to mere existence of semi-conducting nature. Instead, day by day investigations on CNTs reveals that the electrical properties of such carbon nanotubes are much sensitive to chemical doping impacts and charge transfer mechanism in spite of exhibiting extreme robustness [36].
The II type CNTs developed by CVD technique appears to be quasi metallic consisting smaller band gaps in the order of 10 meV. Such CNTs are not sensitive compared to semi-conducting type due to their electrostatic doping mechanism through gate potentials but exhibit a mere conductance dip occluded with that of smaller band gap. These CNTs origin towards a class of non-armchair single walled CNTs and band origin may be due to shift of sp2 to sp3 orbital hybridization which occurs prominently by the existence of non-flat hexagonal nature of tube walls. Quasi metallic types exhibit enhanced electrical conductivity at low temperature levels when subjected to temperature dependent experimental studies [37].
Even quantum interfering impacts were also being observed: (1) phonon acts as the basic scattering mechanism existing in single walled CNTs at ambient conditions and (2) excellent levels of ohmic frequency contacts can be proliferated in the nanotubes with a probability of adequate transmission T = 1 and 3 electron transfer is explicitly phase coherent along with ballistic ability in CNTs at even low temperature levels. This also suggest a lengthy mean distance for ballistic electron transfer in super quality CVD developed SWCNTs [39].
Schematic pattern of growth has been extensively used to obtain suspended CNTs in single wall across certain trenches along with normal nanotubes which may be electrically wired up with relative easiness. By manipulating a suspended CNT using an AFM probe while measuring its electrical conductivity, the impact of mechanical deformation on electrical characteristics of CNT can be judged. The wide scope of CNTs based on nanoelectro-mechanic (NEM) devices are invented to explore twisting pattern of single nanowires, pure stretching levels and also due to their high frequency characteristics of resonance measurements. Operated NEMs switches and accessible memory devices have also been envisioned in nearby future. Powerful control and deterministic mode of synthesis of CNT will further explore exciting opportunities and greater possibilities of finding novel nanomaterials and other devices [38].
SWCNTs are mostly inert in nature. The covalent attachment agglomerated the molecular species with fully bonded sp2 hybridization onto sidewalls of CNT proves to be complex. The adsorbed molecules onto CNTs through the development of non-covalent forces has evidently turned to be facile and consequently lead to possible effects on their physical properties and also with their potential applications. Desorption of orientation molecules from single walled tubes can be achieved by heating the nanotubes to higher temperature levels [40].
Similarly, illumination of UV light at low photon intensity forces a drastic molecular desorption rate from SWCNTs at even ambient conditions whereas, wavelength governing measurements predict that photo-desorption process may occur due to sudden excitation of electrons occluded in the nanotubes and perhaps it is a non-thermal process. The excitation of electrons in specific by ∏ plasmons included in SWCNTs due to UV light results in electron/hole pair formation which occur through Landau damping. The studies portray that surface and photochemistry problems are much predominant to exhibit properties and to create molecular nano surface wires that possess ultrahigh surface distribution with each and every atom accommodating onto the surface. Therefore, surface science study can be evaluated at single wire level itself by incorporating both chemical and electrical properties of CNTs as thin probes [41].
Carbon nanotubes have helpful assimilation, photoluminescence (fluorescence), and Raman spectroscopy properties. Spectroscopic strategies offer the chance of speedy and non-dangerous portrayal of moderately a lot of carbon nanotubes. There is a solid interest for such portrayal from the mechanical perspective: various parameters of nanotube union can be changed, purposefully or accidentally, to modify the nanotube quality. As demonstrated as follows, optical assimilation, photoluminescence, and Raman spectroscopies permit brisk and solid portrayal of this “nanotube quality” as far as non-rounded carbon content, structure (chirality) of the delivered nanotubes, and auxiliary imperfections. These highlights decide about some other properties, for example, optical, mechanical, and electrical properties [42].
Carbon nanotubes are novel “one-dimensional frameworks” which can be imagined as moved single sheets of graphite (or all the more accurately graphene). This rolling should be possible at various points and ebbs and flows bringing about various nanotube properties. The width normally fluctuates in the range 0.4–40 nm (i.e., “just” ~100 times), yet the length can shift ~100,000,000,000 times, from 0.14 nm to 55.5 cm [43]. The nanotube perspective proportion, or the length-to-breadth proportion, can be as high as 132,000,000:1 [44] which is unmatched by some other material. Thusly, all the properties of the carbon nanotubes comparative with those of common semiconductors are incredibly anisotropic (directionally reliant) and tunable.
While mechanical, electrical, and electrochemical (supercapacitor) properties of the carbon nanotubes are entrenched and have quick applications, the down to earth utilization of optical properties is yet muddled. The previously mentioned tunability of properties is conceivably helpful in optics and photonics. Specifically, light-discharging diodes (LEDs) and photograph detectors dependent on a solitary nanotube have been created in the lab. Their exceptional element is not the effectiveness, which is yet moderately low, however the limited selectivity in the frequency of discharge and recognition of light and the chance of its adjusting through the nanotube structure. What’s more, bolometer and optoelectronic memory gadgets have been acknowledged on groups of single-walled carbon nanotubes [45].
Crystallographic absconds additionally influence the cylinder’s electrical properties. A typical outcome is brought down conductivity through the flawed space of the cylinder. An imperfection in easy chair type tubes (which can lead power) can make the encompassing area become semiconducting, and single monatomic opening incite attractive properties.
The characteristic properties ascertained to CNTs are really enthusiastic. in the last decades, many research studies have proposed potential uses of CNTs and also have remarkably portrayed promising applications when such newly developed materials are joined together with typical scientific products, for example, nanorods production using such CNTs as reactive template materials.
Applications of CNTs encompass major fields and various disciplines, which include nanotechnology, medicine, construction, manufacturing, electronics, peripheral hardware, software and so on Figure 7. The mentioned applications can be considered: actuators, composites with maximum strength, energy storage as well as energy conversion equipment, media for H2 storage, nanosensors and probes, electronic instruments and process catalysis. Anyway the forthcoming sections will highlight detailed applications of CNTs in biomedical field. There are three parameters which may act as barriers before using CNTs in the fields of biotechnology and biomedical based industry. These barriers have to be overcome: toxicity, pharmacology and functionalization perspectives of CNTs [46].
CNT applications in biomedical field.
The most prominent barrier is toxic nature of CNTs. In general, the coexistence of maximum surface area rendered by CNT along with the intrinsic toxic nature of nano surface can become most important for the harmful impacts of aggregated nanoparticles. The toxic nature of CNTs can be influenced by the particle size of designed nanotubes. If the particles are less than a size of 100 nm, they are able to exhibit definite harmful effects such as enhanced potential hazard to the liver, lung, protein structure modification, escape from usual phagocytic powerful attacks, activation of immunological and inflammatory responses, and explicit redistribution strategy from their spot of tube deposition [47].
Another predominant barrier with CNT is the pharmacokinetics and bio-distribution of aggregated nanoparticles which are in-turn influenced by distinct physicochemical attributes such as size, shape, aggregation capacity, chemical composition, solubility of surface and effective fictionalization. Previously made studies have demonstrated that CNTs of water soluble nature are much more biocompatible with the inbuilt human body fluids and also do not show any toxic ill-effects or abnormal mortality [48].
The most notable disadvantage of CNTs is the lack of aqueous solubility when exposed to any media and in order to eradicate such a problem, surface modification is introduced on the carbon nanotubes, that is, stable fictionalization of surface with suitable hydrophilic substituents and reaction chemistries which can improve both aqueous solubility as well as biocompatibility of CNT [49].
Nanomaterials portray their chosen probability and thrusted promise in the field of regenerative medicine due to their extraneous physical/chemical properties. In general, the rejected implant materials which may be the cause for post administration implant pain and in order to avoid such rejection, nanotubes were attached to amino acids and to proteins, thereby achieved a promising development. Both the single and multi-walled forms can be effectively utilized as implants which may be either artificial joints or else other implant materials without any kind of host rejection output response. Perhaps, due to its unique material properties such as maximum tensile strength, these can effectively act as implant materials for bone substitutes and if suitably filled with calcium, such implants can be shaped or arranged within the bone structure [50, 51].
It has also been invented that proliferation and cellular adhesion can increase with the availability of SW and MW carbon nanotube composites and hence, these can be essentially integrated into natural nanomaterials and synthetic type materials to fabricate suitable nanocomposites. The specific type of CNT accustomed to artificial implants was represented in Table 2.
Type of CNT | Background materials | Properties | References |
---|---|---|---|
SWCNT impregnated | Chitosan type | Enhancement in cell morphology and growth | [50] |
SWCNT (pore type) | Membrane of polycarbonates | Increase cytoskeletal extensions | [51] |
SWCNT | Sodium alginate | Elevate proliferation | [51] |
MWCNT | Collagen type | Enhancement in cellular adhesion | [52] |
MWCNT | Poly-acrylic acid type | Improves cellular discrimination | [53] |
Nature of CNT in artificial implants application.
The scope of tissue engineering lies in the substitution of damaged tissue using biological alternatives that can possibly replace/repair original and normal function. The recent advances in the emerging fields of material science have been promisingly supported in the growth of tissue engineering and regenerative medicine [54].
CNTs can be recommended for use in the field of tissue engineering under four different perspectives. They are cell tracking/labeling, sensing cellular nature and mechanism, augmenting the mechanism and enhancing the tissue matrices. Cell tracking/labeling is the specific capacity to identify implanted cell structures and to record the noteworthy improvement of tissue growth in vivo as well noninvasively [52]. Labeling of transferred cells by implants not only permits the evaluation of engineered tissue viability but also promotes a deep understanding of migration, bio-distribution, movement pathways and relocation of implanted cells. The non-invasive techniques nowadays become more familiar than traditional techniques such as cytometry owing to more time consumption and practical challenges associated with handling of usage. Hence, CNTs can be more feasible as contrast imaging agents for optical resolution, magnetic resonance behavior and also for radio tracer simulating models [54].
One of the prominent applications of CNTs in the study of tissue engineering is its ability to bio-distribution measurement and also it can be systematically varied using radiotracers applicable to gamma scintigraphy. The proper design of engineered tissue structures enhances and promotes monitoring of cellular physiology that includes protein/metabolite secretion rate, enzyme and other cofactor interactions, cellular growth/mechanism and molecules/ions transport. Novel nanosensors will be effectively utilized in such a way to determine continuous monitoring associated towards the working performance of engineered tissues.
Numerous and popular features involved in the structure of CNTs envisage them to become key elements for nanosensing devices owing to its maximum surface area and DNA or protein immobilizing capacity along with electrical properties [53].
Moreover, these carbon nanotubes possess distinctive electronic structures make the invention of redox active proteins and also amino acids thereby rendering the cell monitoring activity in engineered tissue patterns. In another research, MWNTs were combined with that of platinum micro nanoparticles and also able to identify thiols such as prescribed amino acids which include glutathione and L-cysteine observations in rat.
The cell matrix predominates its function in tissue engineering. Even though, PLA and PLGA have been utilized for tissue engineering, they tend to adopt the inbuilt mechanical strength and cannot be just functionalized pertaining to controversial version of synthetic polymer compounds. Hence, CNTs have potential applications as tissue scaffolds and able to ascertain the structural reinforcement. The only demerit of CNTs is such that they are not biodegradable. When CNTs are dissolved in certain quantity of polymeric substance, rapid enhancement in mechanical strength has been promptly noted. If these MWNTs combine with chitosan material it may lead to advancement in properties whereas SWNT on blending with natural collagen improves the cell growth of smooth muscles [43].
Nanodevices have been investigated that has the effective potential to generate new techniques in cancer treatment, diagnosis as well as detection. The geometric structures of these nanomaterials may be very small (< 100 nm) such that the body will evacuate it rapidly so as to become more efficient either through detection or by imaging and thereby enter the damaged cells and organelles inside the body to have interaction with DNA or protein molecules. The possible detection of cervical cancer causing cells among human beings can be improved by carrying out modification on the graphene electrode using peptide form of nanotube folic acid [55].
As large quantity of cancer types is truly asymptotic throughout their initial stage and also due to absence of specific morphologic modifications among most of the neoplastic disorders in preliminary stage, possibly traditional cancer imaging and clinical methods such as X-ray, CT scan and even MRI scan does not require any kind of spatial resolution for such disease detection in initial stages. Imaging analysis using single walled CNTs have been explored for the past few decades. Coupling of radioisotopes with single walled CNTs along with imaging techniques based on radio nucleotides can progress advancement in tissue sensitivity, penetration as well as nano medium spatial resolution.
Many sophisticated protein biomarkers are available which are often overexpressed in the interior of cancer cells and they offer an entry mark for preliminary diagnosis, maintaining surveillance, prognosis, curative surgery techniques, advancement in disease monitoring therapy and finally detecting therapeutic response. Special categories of tumor biomarkers have been tremendously applied and also conceivably utilized in diagnosis and treatment of hepatocellular carcinoma, pancreatic, colorectal cancer, prostate cancer, ovarian tumor on epithelial cells which includes CA19-9 (carbohydrate antigen), carcinoembryonic antigen (CEA), alpha fetoprotein (AFP), human chorionic gonadotropin (hCG), carcinoma antigen 125 (CA125) and specific antigen to prostate (PSA) [27].
There are various interim obstacles associated with conventional application and administration of chemo-therapic agents which includes system toxicity, lack of proper sensitivity/selectivity, minimum solubility, poor cellular distribution, lagging of certain clinical procedures, and inefficiency of specific drugs to overcome the cellular barriers for achieving the treatment of multidrug resistive cancer disease. Scientists and research experts have conceptualized various drug handling/delivery systems to combat these terrific issues using silica nanomaterials, quantum dots, polymeric materials, dendrimers, liposomes, emulsions, micelles and even molecular conjugates [56, 57].
As discussed above Table 3, CNTs possess specific features such as ultrapure/maximum surface distribution, which essentially provoke them to act as a promising tool for drug delivery, nucleic acids and peptides. The selective drug or desired gene can be effectively coupled with tips and walls of carbon nanotubes and can easily trace out specific cancer causing receptors that are available on the cell structure and thereby such CNTs can even over cross the cell membrane of mammals through the mechanism of endocytosis or other plausible procedures. Thus, it can recognize the therapeutic drugs/genes much more reliably and safely in the affected cells that are reluctantly inaccessible during previous procedures.
Nucleic acid/drug-CNT type | Cell/tissue | Properties |
---|---|---|
Doxorubicin—SWCNT | Colon cancer | Efficient take up of cancer causing cells and then transfers to nucleus |
Radionuclide-SWCNT | Burkitt lymphocytes | Targeted tumor both in vitro/in vivo |
siRNA-SWCNT | Human neuro cells | Improves the working of siRNA assisted gastrin peptide receptor |
Toxic siRNA—MWCNT | Human lung system | Inhibits discrete tumor growth |
Cisplatin—SWCNT | Neuro Carcinoma | Tumor development—drastic recession |
Paclitaxel—SWCNT | Breast cancer | Improved efficacy in treatment with minimal effects |
Release of drugs from CNTs.
Recent discoveries of research experts paved the way to invent novel and efficient single walled CNT based drug delivery tool for targeting tumor which comprises of targeting ligands for tumor, drugs for anticancer treatment and also functionalized single walled CNTs. If such system has an interaction with cancer causing cells, it can provoke the receptor assisted endocytosis by identifying specific receptors to cancer cells onto the affected cell surface and perhaps specifically and efficiently release the active chemotherapeutic agents [58]. The release of drugs using CNTs were highlighted in Table 3.
In cardiology field, the CNTs are used for artificial valves to heart blocks, pacemakers, etc. These CNTs may be involved either as individual or in combined form to synthesize smart sensors and various multi-functional materials. They possess maximum aspect ratios that make the CNT to be extremely ideal for operating longer duration and of course continuous sensing. Their greater surface distribution shall be definitely exploited for providing material deposition in order to generate hybrid variety of functional materials or better functionalized to formulate different electrodes for certain applications [59].
CNTs are much prone to promote its ballistic conductivity which may occur owing to minimum scattering of electrons in their one dimensional solid structure containing mean free paths in the measurable range of tens to microns. The exerted mechanical stress/strain can even aid few reproducible changes acquainted with the electrical properties involved in CNT fibers, thereby felicitating it extremely viable to act as electro mechanical sensor devices. The occluded changes are noted as capacitance, inductance and electric resistance which can be directly correlated to the impact of strain Figure 8. Moreover, such CNTs are hugely responsive to compressive, flexural, tensile /torsional strain [60, 61].
Nanosensor schematic representation.
The working mechanism of sensors derived from a simple CNT macroscopic assembly inculcate the change of their electrical resistance or resistivity resulting from mechanical strain is said to be piezo-resistivity, change of its inductance/capacitance via mechanical strain, variation of its electrical resistivity with a plausible variation with temperature is said to be thermo resistivity and a magnetoresistance may result due to variation in electrical resistance which may be due to varying magnetic field is known as magnetoresistance [62].
Even electrical resistance change can occur owing to variation in mechanical resonance frequency thereby resulting change in temperature, mass, pressure and strain. In contrast, the simultaneous change in electrical conductance/resistance is most predominant than any other mild variation accustomed in electrical properties. This happens partially due to selective and simple separation of charge carriers under the influence of temporary/permanent deformation which may lead to certain elevation in resistance. For every minute strain effects, the deformation is shown to be extremely elastic and the electrically conductive mechanism can be completely withdrawn due to its associated strain removal and thereby leads to a deduction in resistance [63]. However, plastic deformation has been proved to be much different. Though the resistance approaches zero due to strain removal and hence hysteresis curve has been fully observed. The various sensors involved with such CNT fiber yawns were strain type, pressure sensor devices, chemical sensors, and even mass sensors.
Nanomaterials provide an enriched knowledge on distinct probability and also definitely sound well in biomedical regenerative therapy for its uniqueness owing to its excellent physical as well as chemical properties. Thus, CNT both in modified and purified type have a definite potential of establishing promising applications in wide sectors of scientific fields. Perhaps, the prompt impregnation of other substituents in carbon nanoforms would confirm its strong perspective for their enhancing biomedical applications and in general medicine. Still then, there exist questions on unsolved issues whereas proximate homogeneity of the selected nanomaterial contains extensive distribution of nanotubes radius, unlike its geometric structures, classification of nanotubes, trace inclusion of residual elements, and a marked sensitivity to different species and other toxic gases.
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She performed research in perioperative autotransfusion and obtained the degree of PhD in 1993 publishing Peri-operative autotransfusion by means of a blood cell separator.\nBlood transfusion had her special interest being the president of the Haemovigilance Chamber TRIP and performing several tasks in local and national blood bank and anticoagulant-blood transfusion guidelines committees. Currently, she is working as an associate professor and up till recently was the dean at the Albert Schweitzer Hospital Dordrecht. She performed (inter)national tasks as vice-president of the Concilium Anaesthesia and related committees. \nShe performed research in several fields, with over 100 publications in (inter)national journals and numerous papers on scientific conferences. \nShe received several awards and is a member of Honour of the Dutch Society of Anaesthesia.",institutionString:null,institution:{name:"Albert Schweitzer Hospital",country:{name:"Gabon"}}},{id:"83089",title:"Prof.",name:"Aaron",middleName:null,surname:"Ojule",slug:"aaron-ojule",fullName:"Aaron Ojule",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Port Harcourt",country:{name:"Nigeria"}}},{id:"295748",title:"Mr.",name:"Abayomi",middleName:null,surname:"Modupe",slug:"abayomi-modupe",fullName:"Abayomi Modupe",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/no_image.jpg",biography:null,institutionString:null,institution:{name:"Landmark University",country:{name:"Nigeria"}}},{id:"94191",title:"Prof.",name:"Abbas",middleName:null,surname:"Moustafa",slug:"abbas-moustafa",fullName:"Abbas Moustafa",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/94191/images/96_n.jpg",biography:"Prof. Moustafa got his doctoral degree in earthquake engineering and structural safety from Indian Institute of Science in 2002. He is currently an associate professor at Department of Civil Engineering, Minia University, Egypt and the chairman of Department of Civil Engineering, High Institute of Engineering and Technology, Giza, Egypt. He is also a consultant engineer and head of structural group at Hamza Associates, Giza, Egypt. Dr. Moustafa was a senior research associate at Vanderbilt University and a JSPS fellow at Kyoto and Nagasaki Universities. He has more than 40 research papers published in international journals and conferences. He acts as an editorial board member and a reviewer for several regional and international journals. His research interest includes earthquake engineering, seismic design, nonlinear dynamics, random vibration, structural reliability, structural health monitoring and uncertainty modeling.",institutionString:null,institution:{name:"Minia University",country:{name:"Egypt"}}},{id:"84562",title:"Dr.",name:"Abbyssinia",middleName:null,surname:"Mushunje",slug:"abbyssinia-mushunje",fullName:"Abbyssinia Mushunje",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"University of Fort Hare",country:{name:"South Africa"}}},{id:"202206",title:"Associate Prof.",name:"Abd Elmoniem",middleName:"Ahmed",surname:"Elzain",slug:"abd-elmoniem-elzain",fullName:"Abd Elmoniem Elzain",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Kassala University",country:{name:"Sudan"}}},{id:"98127",title:"Dr.",name:"Abdallah",middleName:null,surname:"Handoura",slug:"abdallah-handoura",fullName:"Abdallah Handoura",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"École Supérieure des Télécommunications",country:{name:"Morocco"}}},{id:"91404",title:"Prof.",name:"Abdecharif",middleName:null,surname:"Boumaza",slug:"abdecharif-boumaza",fullName:"Abdecharif Boumaza",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"Abbès Laghrour University of Khenchela",country:{name:"Algeria"}}},{id:"105795",title:"Prof.",name:"Abdel Ghani",middleName:null,surname:"Aissaoui",slug:"abdel-ghani-aissaoui",fullName:"Abdel Ghani Aissaoui",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/105795/images/system/105795.jpeg",biography:"Abdel Ghani AISSAOUI is a Full Professor of electrical engineering at University of Bechar (ALGERIA). He was born in 1969 in Naama, Algeria. He received his BS degree in 1993, the MS degree in 1997, the PhD degree in 2007 from the Electrical Engineering Institute of Djilali Liabes University of Sidi Bel Abbes (ALGERIA). He is an active member of IRECOM (Interaction Réseaux Electriques - COnvertisseurs Machines) Laboratory and IEEE senior member. He is an editor member for many international journals (IJET, RSE, MER, IJECE, etc.), he serves as a reviewer in international journals (IJAC, ECPS, COMPEL, etc.). He serves as member in technical committee (TPC) and reviewer in international conferences (CHUSER 2011, SHUSER 2012, PECON 2012, SAI 2013, SCSE2013, SDM2014, SEB2014, PEMC2014, PEAM2014, SEB (2014, 2015), ICRERA (2015, 2016, 2017, 2018,-2019), etc.). His current research interest includes power electronics, control of electrical machines, artificial intelligence and Renewable energies.",institutionString:"University of Béchar",institution:{name:"University of Béchar",country:{name:"Algeria"}}},{id:"99749",title:"Dr.",name:"Abdel Hafid",middleName:null,surname:"Essadki",slug:"abdel-hafid-essadki",fullName:"Abdel Hafid Essadki",position:null,profilePictureURL:"//cdnintech.com/web/frontend/www/assets/author.svg",biography:null,institutionString:null,institution:{name:"École Nationale Supérieure de Technologie",country:{name:"Algeria"}}},{id:"101208",title:"Prof.",name:"Abdel Karim",middleName:"Mohamad",surname:"El Hemaly",slug:"abdel-karim-el-hemaly",fullName:"Abdel Karim El Hemaly",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/101208/images/733_n.jpg",biography:"OBGYN.net Editorial Advisor Urogynecology.\nAbdel Karim M. A. El-Hemaly, MRCOG, FRCS � Egypt.\n \nAbdel Karim M. A. El-Hemaly\nProfessor OB/GYN & Urogynecology\nFaculty of medicine, Al-Azhar University \nPersonal Information: \nMarried with two children\nWife: Professor Laila A. Moussa MD.\nSons: Mohamad A. M. El-Hemaly Jr. MD. Died March 25-2007\nMostafa A. M. El-Hemaly, Computer Scientist working at Microsoft Seatle, USA. \nQualifications: \n1.\tM.B.-Bch Cairo Univ. June 1963. \n2.\tDiploma Ob./Gyn. Cairo Univ. April 1966. \n3.\tDiploma Surgery Cairo Univ. Oct. 1966. \n4.\tMRCOG London Feb. 1975. \n5.\tF.R.C.S. Glasgow June 1976. \n6.\tPopulation Study Johns Hopkins 1981. \n7.\tGyn. Oncology Johns Hopkins 1983. \n8.\tAdvanced Laparoscopic Surgery, with Prof. Paulson, Alexandria, Virginia USA 1993. \nSocieties & Associations: \n1.\t Member of the Royal College of Ob./Gyn. London. \n2.\tFellow of the Royal College of Surgeons Glasgow UK. \n3.\tMember of the advisory board on urogyn. FIGO. \n4.\tMember of the New York Academy of Sciences. \n5.\tMember of the American Association for the Advancement of Science. \n6.\tFeatured in �Who is Who in the World� from the 16th edition to the 20th edition. \n7.\tFeatured in �Who is Who in Science and Engineering� in the 7th edition. \n8.\tMember of the Egyptian Fertility & Sterility Society. \n9.\tMember of the Egyptian Society of Ob./Gyn. \n10.\tMember of the Egyptian Society of Urogyn. \n\nScientific Publications & Communications:\n1- Abdel Karim M. El Hemaly*, Ibrahim M. Kandil, Asim Kurjak, Ahmad G. Serour, Laila A. S. Mousa, Amr M. Zaied, Khalid Z. El Sheikha. \nImaging the Internal Urethral Sphincter and the Vagina in Normal Women and Women Suffering from Stress Urinary Incontinence and Vaginal Prolapse. Gynaecologia Et Perinatologia, Vol18, No 4; 169-286 October-December 2009.\n2- Abdel Karim M. El Hemaly*, Laila A. S. Mousa Ibrahim M. Kandil, Fatma S. El Sokkary, Ahmad G. Serour, Hossam Hussein.\nFecal Incontinence, A Novel Concept: The Role of the internal Anal sphincter (IAS) in defecation and fecal incontinence. Gynaecologia Et Perinatologia, Vol19, No 2; 79-85 April -June 2010.\n3- Abdel Karim M. El Hemaly*, Laila A. S. Mousa Ibrahim M. Kandil, Fatma S. El Sokkary, Ahmad G. Serour, Hossam Hussein.\nSurgical Treatment of Stress Urinary Incontinence, Fecal Incontinence and Vaginal Prolapse By A Novel Operation \n"Urethro-Ano-Vaginoplasty"\n Gynaecologia Et Perinatologia, Vol19, No 3; 129-188 July-September 2010.\n4- Abdel Karim M. El Hemaly*, Ibrahim M. Kandil, Laila A. S. Mousa and Mohamad A.K.M.El Hemaly.\nUrethro-vaginoplasty, an innovated operation for the treatment of: Stress Urinary Incontinence (SUI), Detursor Overactivity (DO), Mixed Urinary Incontinence and Anterior Vaginal Wall Descent. \nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/ urethro-vaginoplasty_01\n\n5- Abdel Karim M. El Hemaly, Ibrahim M Kandil, Mohamed M. Radwan.\n Urethro-raphy a new technique for surgical management of Stress Urinary Incontinence.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/\nnew-tech-urethro\n\n6- Abdel Karim M. El Hemaly, Ibrahim M Kandil, Mohamad A. Rizk, Nabil Abdel Maksoud H., Mohamad M. Radwan, Khalid Z. El Shieka, Mohamad A. K. M. El Hemaly, and Ahmad T. El Saban.\nUrethro-raphy The New Operation for the treatment of stress urinary incontinence, SUI, detrusor instability, DI, and mixed-type of urinary incontinence; short and long term results. \nhttp://www.obgyn.net/urogyn/urogyn.asp?page=urogyn/articles/\nurethroraphy-09280\n\n7-Abdel Karim M. El Hemaly, Ibrahim M Kandil, and Bahaa E. El Mohamady. Menopause, and Voiding troubles. \nhttp://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly03/el-hemaly03-ss\n\n8-El Hemaly AKMA, Mousa L.A. Micturition and Urinary\tContinence. Int J Gynecol Obstet 1996; 42: 291-2. \n\n9-Abdel Karim M. El Hemaly.\n Urinary incontinence in gynecology, a review article.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/abs-urinary_incotinence_gyn_ehemaly \n\n10-El Hemaly AKMA. Nocturnal Enuresis: Pathogenesis and Treatment. \nInt Urogynecol J Pelvic Floor Dysfunct 1998;9: 129-31.\n \n11-El Hemaly AKMA, Mousa L.A.E. Stress Urinary Incontinence, a New Concept. Eur J Obstet Gynecol Reprod Biol 1996; 68: 129-35. \n\n12- El Hemaly AKMA, Kandil I. M. Stress Urinary Incontinence SUI facts and fiction. Is SUI a puzzle?! http://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly/el-hemaly-ss\n\n13-Abdel Karim El Hemaly, Nabil Abdel Maksoud, Laila A. Mousa, Ibrahim M. Kandil, Asem Anwar, M.A.K El Hemaly and Bahaa E. El Mohamady. \nEvidence based Facts on the Pathogenesis and Management of SUI. http://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly02/el-hemaly02-ss\n\n14- Abdel Karim M. El Hemaly*, Ibrahim M. Kandil, Mohamad A. Rizk and Mohamad A.K.M.El Hemaly.\n Urethro-plasty, a Novel Operation based on a New Concept, for the Treatment of Stress Urinary Incontinence, S.U.I., Detrusor Instability, D.I., and Mixed-type of Urinary Incontinence.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/urethro-plasty_01\n\n15-Ibrahim M. Kandil, Abdel Karim M. El Hemaly, Mohamad M. Radwan: Ultrasonic Assessment of the Internal Urethral Sphincter in Stress Urinary Incontinence. The Internet Journal of Gynecology and Obstetrics. 2003. Volume 2 Number 1. \n\n\n16-Abdel Karim M. El Hemaly. Nocturnal Enureses: A Novel Concept on its pathogenesis and Treatment.\nhttp://www.obgyn.net/urogynecolgy/?page=articles/nocturnal_enuresis\n\n17- Abdel Karim M. El Hemaly. Nocturnal Enureses: An Update on the pathogenesis and Treatment.\nhttp://www.obgyn.net/urogynecology/?page=/ENHLIDH/PUBD/FEATURES/\nPresentations/ Nocturnal_Enuresis/nocturnal_enuresis\n\n18-Maternal Mortality in Egypt, a cry for help and attention. The Second International Conference of the African Society of Organization & Gestosis, 1998, 3rd Annual International Conference of Ob/Gyn Department � Sohag Faculty of Medicine University. Feb. 11-13. Luxor, Egypt. \n19-Postmenopausal Osteprosis. The 2nd annual conference of Health Insurance Organization on Family Planning and its role in primary health care. Zagaziz, Egypt, February 26-27, 1997, Center of Complementary Services for Maternity and childhood care. \n20-Laparoscopic Assisted vaginal hysterectomy. 10th International Annual Congress Modern Trends in Reproductive Techniques 23-24 March 1995. Alexandria, Egypt. \n21-Immunological Studies in Pre-eclamptic Toxaemia. Proceedings of 10th Annual Ain Shams Medical Congress. Cairo, Egypt, March 6-10, 1987. \n22-Socio-demographic factorse affecting acceptability of the long-acting contraceptive injections in a rural Egyptian community. Journal of Biosocial Science 29:305, 1987. \n23-Plasma fibronectin levels hypertension during pregnancy. The Journal of the Egypt. Soc. of Ob./Gyn. 13:1, 17-21, Jan. 1987. \n24-Effect of smoking on pregnancy. Journal of Egypt. Soc. of Ob./Gyn. 12:3, 111-121, Sept 1986. \n25-Socio-demographic aspects of nausea and vomiting in early pregnancy. Journal of the Egypt. Soc. of Ob./Gyn. 12:3, 35-42, Sept. 1986. \n26-Effect of intrapartum oxygen inhalation on maternofetal blood gases and pH. Journal of the Egypt. Soc. of Ob./Gyn. 12:3, 57-64, Sept. 1986. \n27-The effect of severe pre-eclampsia on serum transaminases. The Egypt. J. Med. Sci. 7(2): 479-485, 1986. \n28-A study of placental immunoreceptors in pre-eclampsia. The Egypt. J. Med. Sci. 7(2): 211-216, 1986. \n29-Serum human placental lactogen (hpl) in normal, toxaemic and diabetic pregnant women, during pregnancy and its relation to the outcome of pregnancy. Journal of the Egypt. Soc. of Ob./Gyn. 12:2, 11-23, May 1986. \n30-Pregnancy specific B1 Glycoprotein and free estriol in the serum of normal, toxaemic and diabetic pregnant women during pregnancy and after delivery. Journal of the Egypt. Soc. of Ob./Gyn. 12:1, 63-70, Jan. 1986. Also was accepted and presented at Xith World Congress of Gynecology and Obstetrics, Berlin (West), September 15-20, 1985. \n31-Pregnancy and labor in women over the age of forty years. Accepted and presented at Al-Azhar International Medical Conference, Cairo 28-31 Dec. 1985. \n32-Effect of Copper T intra-uterine device on cervico-vaginal flora. Int. J. Gynaecol. Obstet. 23:2, 153-156, April 1985. \n33-Factors affecting the occurrence of post-Caesarean section febrile morbidity. Population Sciences, 6, 139-149, 1985. \n34-Pre-eclamptic toxaemia and its relation to H.L.A. system. Population Sciences, 6, 131-139, 1985. \n35-The menstrual pattern and occurrence of pregnancy one year after discontinuation of Depo-medroxy progesterone acetate as a postpartum contraceptive. Population Sciences, 6, 105-111, 1985. \n36-The menstrual pattern and side effects of Depo-medroxy progesterone acetate as postpartum contraceptive. Population Sciences, 6, 97-105, 1985. \n37-Actinomyces in the vaginas of women with and without intrauterine contraceptive devices. Population Sciences, 6, 77-85, 1985. \n38-Comparative efficacy of ibuprofen and etamsylate in the treatment of I.U.D. menorrhagia. Population Sciences, 6, 63-77, 1985. \n39-Changes in cervical mucus copper and zinc in women using I.U.D.�s. Population Sciences, 6, 35-41, 1985. \n40-Histochemical study of the endometrium of infertile women. Egypt. J. Histol. 8(1) 63-66, 1985. \n41-Genital flora in pre- and post-menopausal women. Egypt. J. Med. Sci. 4(2), 165-172, 1983. \n42-Evaluation of the vaginal rugae and thickness in 8 different groups. Journal of the Egypt. Soc. of Ob./Gyn. 9:2, 101-114, May 1983. \n43-The effect of menopausal status and conjugated oestrogen therapy on serum cholesterol, triglycerides and electrophoretic lipoprotein patterns. Al-Azhar Medical Journal, 12:2, 113-119, April 1983. \n44-Laparoscopic ventrosuspension: A New Technique. Int. J. Gynaecol. Obstet., 20, 129-31, 1982. \n45-The laparoscope: A useful diagnostic tool in general surgery. Al-Azhar Medical Journal, 11:4, 397-401, Oct. 1982. \n46-The value of the laparoscope in the diagnosis of polycystic ovary. Al-Azhar Medical Journal, 11:2, 153-159, April 1982. \n47-An anaesthetic approach to the management of eclampsia. Ain Shams Medical Journal, accepted for publication 1981. \n48-Laparoscopy on patients with previous lower abdominal surgery. Fertility management edited by E. Osman and M. Wahba 1981. \n49-Heart diseases with pregnancy. Population Sciences, 11, 121-130, 1981. \n50-A study of the biosocial factors affecting perinatal mortality in an Egyptian maternity hospital. Population Sciences, 6, 71-90, 1981. \n51-Pregnancy Wastage. Journal of the Egypt. Soc. of Ob./Gyn. 11:3, 57-67, Sept. 1980. \n52-Analysis of maternal deaths in Egyptian maternity hospitals. Population Sciences, 1, 59-65, 1979. \nArticles published on OBGYN.net: \n1- Abdel Karim M. El Hemaly*, Ibrahim M. Kandil, Laila A. S. Mousa and Mohamad A.K.M.El Hemaly.\nUrethro-vaginoplasty, an innovated operation for the treatment of: Stress Urinary Incontinence (SUI), Detursor Overactivity (DO), Mixed Urinary Incontinence and Anterior Vaginal Wall Descent. \nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/ urethro-vaginoplasty_01\n\n2- Abdel Karim M. El Hemaly, Ibrahim M Kandil, Mohamed M. Radwan.\n Urethro-raphy a new technique for surgical management of Stress Urinary Incontinence.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/\nnew-tech-urethro\n\n3- Abdel Karim M. El Hemaly, Ibrahim M Kandil, Mohamad A. Rizk, Nabil Abdel Maksoud H., Mohamad M. Radwan, Khalid Z. El Shieka, Mohamad A. K. M. El Hemaly, and Ahmad T. El Saban.\nUrethro-raphy The New Operation for the treatment of stress urinary incontinence, SUI, detrusor instability, DI, and mixed-type of urinary incontinence; short and long term results. \nhttp://www.obgyn.net/urogyn/urogyn.asp?page=urogyn/articles/\nurethroraphy-09280\n\n4-Abdel Karim M. El Hemaly, Ibrahim M Kandil, and Bahaa E. El Mohamady. Menopause, and Voiding troubles. \nhttp://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly03/el-hemaly03-ss\n\n5-El Hemaly AKMA, Mousa L.A. Micturition and Urinary\tContinence. Int J Gynecol Obstet 1996; 42: 291-2. \n\n6-Abdel Karim M. El Hemaly.\n Urinary incontinence in gynecology, a review article.\nhttp://www.obgyn.net/urogyn/urogyn.asp?page=/urogyn/articles/abs-urinary_incotinence_gyn_ehemaly \n\n7-El Hemaly AKMA. Nocturnal Enuresis: Pathogenesis and Treatment. \nInt Urogynecol J Pelvic Floor Dysfunct 1998;9: 129-31.\n \n8-El Hemaly AKMA, Mousa L.A.E. Stress Urinary Incontinence, a New Concept. Eur J Obstet Gynecol Reprod Biol 1996; 68: 129-35. \n\n9- El Hemaly AKMA, Kandil I. M. Stress Urinary Incontinence SUI facts and fiction. Is SUI a puzzle?! http://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly/el-hemaly-ss\n\n10-Abdel Karim El Hemaly, Nabil Abdel Maksoud, Laila A. Mousa, Ibrahim M. Kandil, Asem Anwar, M.A.K El Hemaly and Bahaa E. El Mohamady. \nEvidence based Facts on the Pathogenesis and Management of SUI. http://www.obgyn.net/displayppt.asp?page=/English/pubs/features/presentations/El-Hemaly02/el-hemaly02-ss\n\n11- Abdel Karim M. El Hemaly*, Ibrahim M. 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