Summary of summation folds of the athletes.
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\r\n\tThe aim of this book project is to compile the updated research work on medicinal applications of noble metal complexes mainly focusing the structure activity relationship of metal complexes with targeting biological components.
Nutrition is strongly linked to health, especially when sports are concerned, due to the increase in energy and nutrient demands. It is necessary to know the physiology of the exercise in order to know the different metabolic pathways that coexist during sports practice. In this way, you can predict the changes that occur in the organism during physical effort, in order to achieve some dietary recommendations.
\nThe nutritional practices of athletes are multifactorial and depend on the habits, culture, or nutritional knowledge of the athlete. So the work of a sports nutritionist is to advise the athlete and his environment to make the necessary changes in his intake and thereby improve sports performance (SP).
\nNutrition is determinant in achieving an adequate SP, which is defined by three variables: training, rest, and feeding. However, the main objective of sports nutrition must be preserving the health of the athlete, which can be achieved with an adequate intake adapted to the type of training performed. Optimal nutrition provides the energy necessary to perform physical exercise while reducing injury rate, a factor that together makes the SP increase by itself.
\nTwo of the aspects that can limit the SP are the state of hydration and the energy contribution. Hypohydration states produce alterations in homeostasis, decreased blood volume, increased heart rate, lower rate of sweating, increased organism temperature, and greater perception of effort which translates into SP deterioration. Likewise, a low energy consumption accentuates fatigue, immunosuppression, and predisposition for injuries, which can interfere in the development of SP.
\nNowadays, an exponential increase in the population that performs physical activity has been reported. In the USA, the total number of runners endorsed in marathon events is 541,000 in 2013, which represents 27% more participants than observed in 2008 in the same trend observed in many countries. For example, in Spain the number of participants increased from 28,000 (2008) to 57,931 (2013), which represented an increase of 101%. These increases far from ceasing have continued growing in the last 5 years. Specifically, marathons of Sevilla and Valencia have reached 14,500 and 20,000 runners in 2018, which contrast with the previous participation observed in 2013 (5963 and 9653 participants, respectively).
\nUnfortunately, sports nutrition is often referenced to sports supplements or “magical” strange diets. In fact 40–70% of athletes use sports supplements without even analyzing if their use is really necessary.
\nThe body composition (BC) of the athletes is related to the SP, as it can be modified throughout the season. There is no single BC for each group of athletes; however, it can serve as a guide for athletes and coaches [1].
\nThe season of the athlete will be divided into different phases throughout the competitive period. Competitive season can be divided in preseason, competitive period, transition period, and in the worst case injury period. Due to different intensities, timing, and types of training, the BC is normally different in the competitive season. Therefore, it is vital to know the BC of the athletes in order to determine the adequacy of the current season stage [2].
\nApart from a higher body mass index (BMI), there are several methods for the evaluation of BC [2]. Dual-energy X-ray absorptiometry (DEXA) is considered the gold standard for the assessment of body fat, mainly due to its high reproducibility and accuracy. However, DEXA has high economic cost, is not portable, and also emits a small radiation, so its use is not very common [3].
\nAmong the most used methods are bioelectrical impedance analysis (BIA) and anthropometry. Impedance is defined as the opposition shown by biological materials to the passage of an electric flow. Tissues with high impedance offer greater resistance (adipose tissue, bone, air in the lungs) and contain less amount of water [4]. The greater the amount of water, the better this electrical flow, will pass through. Therefore, the hydration sate of the individual is the determinant for the BC measurement by BIA. In addition, in order to standardize previous conditions and dismiss errors, certain protocols must be followed prior to the measurement of BC by BIA. That fact makes BIA a rather imprecise method [5].
\nAnthropometry allows the evaluation of different body dimensions and the overall composition of the body. It consists of the measurement of skinfolds, perimeters of the muscles, and bone diameters. This technique must be carried out by experts qualified by the International Society for the Advancement of Kinanthropometry (ISAK) [4]. It is the most widely used method in the sports field, from which the percentages of fat, muscle mass, and bone mass can be obtained by means of mathematic formulas [5]. The most effective way to monitor an athlete using this technique is performing a sum of six bodyfolds (triceps, subscapular, supraspinal, abdominal, thigh, and medial leg) that gives an absolute value [6]. In summary mode, the values for said summation of folds are estimated in physically active people (75 mm men and 100 mm in women), footballers (<50 mm men and <65 mm women), and endurance athletes (<35 mm men and 50 mm women). The minimum values seen in the healthy sports population were 25 mm for men and 42 mm for women (Table 1).
\nPopulation | \nMen (∑six skinfolds) | \nWomen (∑six skinfolds) | \n
---|---|---|
Physically active people | \n75 | \n10 | \n
Footballers | \n<50 | \n<65 | \n
Runners | \n<35 | \n50 | \n
Minimum value | \n25 | \n42 | \n
Summary of summation folds of the athletes.
However, it must be taken into account that BC is not the only thing that will measure sports performance, but it is one more parameter of the measurements that must be made in the athlete.
\nPrior to establishing requirements regarding quantity and timing of macronutrients, a brief approach about different metabolic pathways that provides energy during exercise is necessary. The energy systems are integrated by a set of metabolic pathways that come into operation during exercise, depending on the intensity and duration. In summary, they can be divided into non-oxidative pathways (phosphogenic and glycolytic pathways) and aerobic pathways (nutrient oxidation) [1].
\nBoth pathways aim to generate ATP that will be consumed during the exercise. The non-oxidative pathways occur in the cellular cytosol, do not require oxygen, and are activated during short-time periods (seconds). Phosphagen route uses ATP and phosphocreatine, lasting between 1 and 10 s, and is a route that does not need oxygen and does not generate lactate. Glycolytic pathways metabolize glucose, muscle, and liver glycogen through glycolysis and occur in high-intensity exercises up to 3 min. These glycolytic pathways generate lactate and hydrogen bonds, generating an acidity in the muscle cell—this acidity being one of its limitations [7].
\nThe aerobic pathway occurs inside the mitochondria, so it requires the presence of oxygen to metabolize fuels. It is typical of resistance exercises with medium-low intensity and long duration. It includes the oxidation of CHOs, fats, and to a lesser extent proteins. This route generates much more ATP than the anaerobic path but more slowly, speed being the limitation of this path [7].
\nThe key to success for any athlete will be to adapt energy intake to energy expenditure, which allows the correct functioning of the organism while improving BC [1]. However, it can be complicated due to multiple changes in periodization of training and competitions.
\nThe energy demands of athletes differ widely depending on the type of sport, duration, intensity, competitive level, and individual variability of each athlete. The more demanding the competitive levels of the athlete are, the greatest increase in the intensity of both training and competition occurs, which will result in a significant reduction energy reserves that must be replaced by an adequate diet [8].
\nThe objectives of the athletes’ diet are the following: provide the necessary energy for exercise, regulate body metabolism, and provide nutrients to maintain and repair tissues [9]. Due to variation among athletes, different available food options, and individual food patterns, there is no single feeding pattern for athletes, so there are a large number of strategies and options to assess [2].
\nCaloric intakes below the basal metabolic rate (BMR) are not recommended because it can compromise organism functions. Depending on the type of training energy requirement, the following recommendations for athletes can be approached: moderate training 1.7 × BMR, intense training 2.1 × BMR, extreme training 3 × BMR, and with the maximum recommended limit being 4 × BMR.
\nAthletes should bear in mind that it is not enough to pay attention to food only on the day of competition, but daily. Appropriate nutritional guidelines will optimize SP, improve recovery, and reduce the risk of injury and illness [2]. For example, in women daily intake below 30 kcal/kg body mass/day can induce damage to metabolic and hormonal functions that affect SP, growth, and health [10].
\nA varied diet is recommended, covering energetic requirements, and is based on foods as fruits, vegetables, legumes, cereals, dairy products, eggs, fish, and lean meat, in order to provide vitamins and minerals. A poor choice of foods cannot be compensated by the use of supplements [2].
\nIn order to establish recommendations for macronutrients, it is preferable taking into account the body weight (BW) of the athlete, instead of giving the typical percentages based on the total caloric intake of the diet [2]. For this purpose the recommendations will be provided by grams of nutrient/kg of BW.
\nMain energy substrates used for physical exercise are carbohydrates (CHO) and lipids, while proteins as energy substrate are reserved for extreme conditions. The use of energy substrate varies depending on the intensity and duration of the exercise, level of training of the athlete, and the state of pre-workout CHO stores. The use of CHO as energy substrate is produced mainly during high-intensity and short-duration exercises. Meanwhile, less intense and long-term exercises use fats’ main energy substrate [11]. However the use of CHO will also have a great impact on exercises of less intensity and longer duration such as resistance test, showing that depletion of CHO together with dehydration is a major limitation of the SP [12].
\nOne of the big differences between CHO and lipids is their storage in the body. While CHOs have a limited reserve which leads to around 1600–2000 kcal, fats suppose a practically unlimited energy reserve close to 70,000 kcal (depending on fat mass) [7, 11].
\nCurrently, there are a large number of myths related to nutrition, which causes great confusion in general population. One of the most widespread errors is the demonization suffered by the CHO, which has generated some carbophobia in society, including the athlete population [13]. This is a mistake, due to the importance of CHO as energy substrate for the brain and central nervous system. Moreover, they can also be used at different intensities both by anaerobic and aerobic pathways [1].
\nCHO are an energy fuel that provides 4 kcal/g of dry weight. They are stores in liver and muscle in the form of glycogen. Although, these deposits are limited to around 400-500 g, providing 1600- 2000 kcal, they can be depleted if the diet does not contain enough CHO. Glycogen stores in the organism are divided into 350–400 g in the muscle, 75–100 g in the liver, and around 5 g in the plasma [14]. In addition to size differences, the liver is really a store of glycogen, responsible for maintaining blood glucose. Meanwhile, the muscle can be considered a “false” store since it only uses glucose for its own needs. In other words, the liver can contribute to the replacement of muscle glycogen in the event of depletion, something that does not happen in reverse, which can lead to hypoglycemia and considerably affect SP due to fatigue [15].
\nIt is vitally important to maintain high levels of glycogen so as not to compromise the physical demands of physical activity, since low availability can be associated with loss of abilities and impaired decision-making and increases risk of injury and decreases SP. Therefore, it is essential to provide CHO before exercise, as well as during, in order to improve the SP and delay the onset of fatigue [14, 16].
\nA good strategy in order to optimize increased glycogen reserves for a competition is the “CHO overload” in the hours or even days before. In athletes with good training status, it is not necessary to deplete these deposits previously, as was believed decades ago. In fact an intake or around 10 g CHO/kg/day during the previous 36–48 h would be enough [17]. Athletes are advised to test how many CHOs are able to inatek without gastric problems. On the other hand, it is also advisable not to try new things on competition days [14].
\nIn general, the CHO recommendations based on the intensity and duration of physical activity can be summarized as follows [1, 18]:
3–5 g/kg/d of low-intensity training such as recovery days or tactical skills
5–7 g/kg/d for moderate intensity training of 1 h duration
6–10 g/kg/d for moderate–high intensity exercises between 1 and 3 h
8–12 g/kg/d for workouts of more than 4–5 h of moderate-high intensity
During competition as well as during high-intensity training, a high intake of CHO between 3 and 4 h before the beginning of the exercise is convenient, in order to complete glycogen levels [14]. In case of CHO overload, the recommendation ranges from 200 g CHO to 300 g CHO of moderate glycemic index. The intake should be light, easily digestible, and low in fat, protein, and fiber, in order not to decrease glycemia. Also, an intake of 1–4 g/kg of CHO between the previous 1 and 4 h would be recommended. However, some athletes should be careful with the intake of simple CHOs in the hour before the competition, which can cause a reactive hypoglycemia that affects the SP [18].
\nThe type of exercise, length, and provisioning are determinant factors for the physical exercise. Depending on all the variables, the nutritional strategies will be adapted to the athlete as personalized as possible. To summarize, the recommendations of CHO during the exercise are [19, 20]:
In an exercise of less than 30 min, CHO intake is not necessary.
In exercise lasting 45–75 min, it seems that the intake of CHOs is not necessary and it would be enough to perform mouth rinses. However, ingesting this liquid can promote hydration.
In exercises lasting 1–2 h, the intake of 30 g/h seems to be sufficient, increasing CHO intake up to 60 g/h in case of more delayed sports.
In exercises lasting more than 2.5 h, the intake of CHO should be 90 g/h. High CHO amounts can cause digestive problems; therefore, a previous intestine training is determinant to tolerate such CHO intake.
The rate of glucose oxidation is estimated at 60 g/h. Therefore, the CHO composition must be formed by a combination of CHOs that use different transporters and increase the oxidation rate, such as maltodextrin or sucrose, among others [20]. Consuming 90 g CHOs/h can cause gastrointestinal problems in sports such as continuous running. These gastrointestinal problems may be due to the redistribution of blood flow to the muscles during exercise. Therefore, strategies for bowel training have been proposed to increase the rate of gastric emptying as well as reduce possible discomfort [21]. When it is proposed to reach recommendations, it seems beneficial to alternate different types of drinks, gels, or bars, so that the taste is not monotonous.
\nThe reposition of CHO is determinant in approaching the following training or competitive sessions. After the completion of physical activity, it is vitally important to replenish CHO stores after the training and competition sessions. These replacements of CHO levels can be approached by different methods, depending on the closeness and intensity of the next sporting event. It will be necessary to rehydrate and to ensure glycogen recovery as well as muscle tissue. The optimum approach is a recovery of 150% of BW lost and a CHO intake between 1 and 2 g/kg/h during the following 6 h after exercise. Moreover, it is advisable to take advantage of the first 2 h afterward where the glycogen resynthesis rate is maximum [14, 22].
\nThe contribution of 1 g/kg BW of CHO after the first hour post-exercise has anticatabolic effect, increases insulin secretion, and increases muscle protein synthesis. Moreover, the addition of protein may also increase the glycogen resynthesis, so a less aggressive pattern can be reached by combining a consumption of 0.8 g kg BW/h of CHO together with protein intake of 0.2–0.4 g/kg BW/h [19].
\nThe appropriate intake of CHO before, during and, after exercise ensures a satisfactory energy intake to face both training and competitions. Most CHOs are found in cereals, fruits, legumes, and vegetables and can be found in smaller quantities in dairy products, unless they could have added sugars. Given the importance of CHO, it is considered essential that athletes ingest enough CHO complexes during the course of the day, leaving simple CHOs during and after exercise [2].
\nHowever, in some circumstances in which physiological adaptations to training are the target, different strategies can be handled to those previously mentioned. For example, training with low availability of glycogen induces mitochondrial biogenesis (increase in the number of mitochondria) and thereby enhances lipid oxidation [23]. This strategy can make the athlete more profitable metabolically, allowing a saving of glycogen reserves during exercise and thereby delaying the onset of fatigue. Another purpose of this strategy can be to accustom the athlete to know the feeling of emptiness that can have at the end of a competition and know in advance how to deal with it [24].
\nBecause a reduction in the availability of CHO will affect the quality of the training, these strategies should be carried out with extreme caution and under the supervision of nutritionist and coach. The performance of training under low availability of CHO will be done during low-intensity sessions due to the perception of effort is greater, the immune system can be affected, and the athlete is at greater risk of injury [24].
\nThe proteins are composed of amino acid (AA) chains. There are 20 types of AA, divide into nonessential AAs (can be synthetized by the organism) and essential AAs (must be contributed by the diet) [2]. Within the essential AAs, there are three types of AAs called branched (leucine, valine, and isoleucine). Among them, leucine stands out as a stimulator of the mammalian target of rapamycin (mTOR) pathway, which is related to protein synthesis and hypertrophy [25].
\nAlthough proteins can contribute between 5 and 10% to the total energy used during physical activity, they are not considered as energy source. Proteins constitute the base of muscle tissue and of the immune system and are the major component of muscle enzymes and play a large role in SP [14].
\nRegarding sedentary population, the estimated consumption rate is 0.8 g/kg BW/day. In the athlete population, these requirements are increased to repair muscle damage caused by exercise, enhance metabolic adaptations to training, and avoid possible muscle catabolism [2]. The focus of protein consumption is on estimating an adequate protein intake for each given moment [1].
\nThe current recommendations for athlete population range between 1.2 and 2.0 g/kg BW/day depending on the type of sports performed [1]. Moreover, higher amounts may be reached at exceptional times such as injurious period, high-intensity training, or weight loss plans with caloric restriction. The purpose of this increase is to maintain maximum muscle mass integrity [26].
\nAlthough the most important factor in terms of protein consumption is the overall consumption throughout the day, it may be advisable to divide the protein intake into several intakes. For example, four doses of 0.4 g/kg BW ensuring a total of 1.6 g/kg BW a day [25]. Likewise, it is recommended to ensure a contribution of 3 g of leucine every meal [27]. The optimal timing seems to adjust the intake depending on the moment, type of training, as well as availability of the rest of nutrients and energy. It is important to have an adequate energy and CHO consumption, so that dietary amino acid are used for protein synthesis and not oxidized to obtain energy [28].
\nProtein-rich diets are associated with increased risk of dehydration due to elimination of nitrogenous waste products, an increased cardiovascular disease risk due to the association of fat with protein products, or a shift of CHO [2]. However, even at high doses, no negative effects on renal function have been reported in healthy subjects.
\nRegarding timing of protein intake along with exercise, it seems that the most optimal time is the period after exercise. Better doses ranged between 0.25 and 0.3 g/protein/kg BW (approximately 15–25 g protein) [1]. However, high protein intake is discouraged close to physical exercise, due to possible digestive problems as a result of its long time of gastric emptying. However, in very long duration exercise, there is not such limitation.
\nIn order to stimulate muscle protein synthesis, the intake of 30–40 g of casein is beneficial prior to going to bed, promoting nocturnal recovery due to its slow digestion [29].
\nTo choose protein sources, it is important that animal proteins may be of greater interest. In fact, animal proteins are considered as a complete protein due to the presence of all essential AAs [30].
\nThe main protein sources are lean meat products, fish, eggs, dairy products, and legumes that provide vegetable protein and reduce animal consumption.
\nThe use of protein supplements does not seem to be necessary because protein requirements are usually reached with diet in Western population. However, population that may find it difficult to reach such recommendations should be monitored. These groups includes: vegetarian athletes, young athletes in the growth phase, and athletes who restrict their diet due to religious or cultural reason. can be included [2]. If protein supplementation is chosen, the best option is whey protein for its high content on AAs and leucine content.
\nAlong with the CHO, lipids are major energy substrates during exercise [27]. The difference is that fats are not as profitable per unit of time as CHO and high fat consumption is not associated with improvements in SP [31].
\nLipid consumption is important for both energy intake and essential nutrients such as fat-soluble vitamins A, D, E, and K. Both quantity and quality of fats are determinant in the diet. The quality is often referred by its content on inflammatory fatty acids [2].
\nThe recommendation regarding fat consumption in athletes is similar to that of the general population. It is advisable not to make restrictive consumption of fat, as it can lead to deficit of nutrients such as fat-soluble vitamins and omega-3 fatty acids [1].
\nFatty acid requirements, according to the American College of Sports Medicine (ACSM), are 20–35% of the total kcal of the diet, where 7–10% should correspond to saturated fatty acids, 10% to polyunsaturated fatty acids, and 10–15% to monounsaturated fatty acids [32].
\nAdequate intake of omega-3 fatty acids should be ensured due to its anti-inflammatory effects, improvements in the organism’s coagulation, or increase in omega-3/omega-6 ratio [33].
\nIn particular, food as avocado or olive oil is recommended, due to their high content on monounsaturated fatty acids, which have less susceptible to oxidation.
\nIt is recommended to reduce the consumption of fatty meats, substituting them for lean meats, fish, and legumes. It is also advisable to eliminate the consumption of processed products such as sausages [2].
\nAn excess of polyunsaturated fatty acids carries a risk of lipid peroxidation, so a joint intake with vitamin E is recommend. Moreover, the ratio omega-3/omega-6 series should be greater as possible, because of the greater pro-inflammatory character of omega-6. The recommendations regarding the omega-6/omega-3 range oscillate between 2 and 4/1 in favor of the omega-6, something that is far from the inflammatory level that this entails [33]. In order to reduce the omega-6/omega-3 ratio, it is advisable to reduce consumption of meats and increase consumption of blue fish such as sardines, salmon, tuna, anchovy, and mackerel.
\nDuring exercise, increments of energy requirements are associated to larger production of metabolic heat [34]. Human organism dissipates that extra heat mainly by the mechanism of evaporation, which ultimately induces dehydration [35, 36].
\nOne of the greatest limitations of SP is dehydration. It is estimated that each kg of BW lost during exercise corresponds to 1 L of sweat [35]. The sensitivity to dehydration is personal, but generally no losses greater than 2% of the BW are recommended in order not to compromise the SP [37]. In fact, 1% of BW lost leads to SP decrease by 10%. Some authors have raised the possibility of training dehydration, but there is some controversy about it [38, 39].
\nThe consumption of water is the only method to prevent dehydration and will be essential before, during, and after exercise. However, a large number of athletes usually begin the exercise in a state of hypohydration [40]. Therefore, it is necessary to instruct the athlete to acquire correct hydration habits according to the type of sports, so that the SP is affected as little as possible [12].
\nLosses of electrolytes, especially sodium, occur along with water losses. It has been seen that well-trained athletes “sweat more but swear better,” that is, they sweat more water, but the loss of electrolytes is lower [41]. Recent studies have compared both the rate of sweating and the concentration of sodium in tattooed people versus non-tattooed people, concluding that the most tattooed skin presented lower sweating rate and higher sodium concentration [42].
\nIt seems interesting to perform a sweat test to athletes, in order to know their rate of sweating (liters/hour). To accomplish it, weighing the athlete before and after the exercise session is enough. This data reveals the amount of sweat that is lost at the time, so it can serve to adjust the athlete’s water intake (Figure 1). [43]. In general, the rate of sweating is usually greater than that of gastric emptying. However athletes can be trained to increase gastric emptying during workouts and thereby reduce dehydration as possible [21]. In conditions of higher temperature and humidity, this rate of sweating will rise higher. Another simpler way to determine the state of hydration in athletes is controlling the color of urine (darker colors are associated with enhanced dehydration states) [2].
\nHow to calculate sweat rate? [43].
Wherein some cases, athletes must acclimatize to different temperatures they accustomed. It has been reported that among all factors, the most important factor is the previous state of hydration.
\nIn healthy non-athlete population, the sensation of thirst is an ancestral mechanism that informs of the need to ingest liquid. However, in children, elderly people, and athletes, this mechanism is altered and liquid should be ingested before presenting thirst sensation. In the case of athletes, thirst appears when there is a deficit of 2% dehydration [27]. However, special care should be taken to amateur athletes, who increase their water intake above their needs, which can suffer dilutional hyponatremia “leading to serious problems and even lead to death” [44].
\nRegarding the drink to be used for sports, it is advisable to use replacement drinks instead of water, due to the CHO and sodium content. Both salts and CHO improve intestinal transport, which facilitates the arrival of fluid in the blood. Prepositional beverages should present an isotonic composition, with the following characteristics [12]:
80–35 kcal
At least 75% of the kcal should be high glycemic index CHO
No more than 90 g CHO/liter
460–1150 mg sodium/liter
Osmolality 200–330 mOsm/kg of water
As commented before, it is advisable to use drink with different CHOs as glucose, sucrose, and maltodextrinas, in order to facilitate the absorption of liquid due to the use of different intestinal transporters. Moreover, the fructose content should not be very high, due to quantities between 20 and 30% can cause intestinal problems [22].
\nThe hydration guidelines indicated for performing physical exercise are [12, 14]:
Ingest between 400 and 600 ml of water along the 4 h before the start of the exercise.
Just at the beginning of the activity, ingest 200–400 ml of water with CHO (5–8%).
During the exercise, ingest 100–200 ml of water every 15–20 min.
After physical activity consume 150% of the BW lost in the 6 h after.
In low-intensity training and short-duration, the intake of water alone is sufficient
The ideal temperature of drinks oscillates between 15 and 21°C
The taste should be pleasant to the palate of the athlete.
In a situation where the environment is very hot and has high humidity, the recommendations of intake of liquid and sodium will be higher [22]. A good strategy can be to make salted snacks in the hours before the exercise or add more salt content to the meals before and after the exercise. Such increase of sodium has a double purpose, on the one hand to increase the intake of liquid through thirst and on the other to favor the retention of that liquid in the organism.
\nFinally, alcohol consumption is discouraged in both athletes and non-athletes. However, there seems to be a high consumption of this substance in team sports and greater consumption in men than women [45]. Among the harmful effects of alcohol consumption, the following can be highlighted: reduction of SP due to decrease in strength, power, speed, and resistance; diuretic effect that affects hydration [46]; diminution of sleep quality, mood, and immune system [47]; elevation of cortisol concentration; and reduction of muscle synthesis up to 24% even when consumed right at the end of the exercise [48].
\nFirst, the effect of exercise between insulin-dependent (type 1) and insulin-dependent (type 2) diabetes should be differentiated. In type 2, you do the exercise to improve insulin resistance, while in type 1, you should adjust and modify the amount of insulin administered, along with the CHO intake.
\nPhysical exercise is one of the most difficult activities to adapt to diabetes, due to the increase in the frequency of hypoglycemia. People with diabetes who perform physical activity on a regular basis have less need for insulin, but this does not ensure adequate glycemic control. The blood glucose value is of multifactorial origin, and one should take into account the CHO intake and type of sports performed as well as adjust the dose of insulin used [49].
\nIn order to avoid hypoglycemia, during the exercise the dose of insulin will be reduced but in no case will be completely eliminated, because the lack of insulin prevents the entry of a sufficient amount of glucose into the cells for obtaining energy. A greater use of fats as fuel can generate an accumulation of ketone bodies and cause ketoacidosis. In the presence of glucose values (>250 mg/dL), ketone levels should be checked, and if elevated (>0.5 mmol/l), postpone the activity [49].
\nThe type of exercise performed by the athlete should be taken into account, since aerobic exercise increases the risk of hypoglycemia during and after exercise, while anaerobes cause hyperglycemia due to counterregulatory hormones (glucagon, cortisol, and catecholamines) [49].
\nPhysical exercise has some ability to introduce glucose into the muscle cell without the need for insulin action. This effect can occur during the 48 h after exercise, so there is a certain risk of suffering hypoglycemia in that period depending on the sports performed. This is due to the fact that during the physical exercise, the reserves of the muscle and liver glycogen have been emptied. Once the exercise is finished and after the intake of CHO, the glucose will be destined to replace the glycogen reserves instead of the blood, which can cause hypoglycemia, so that the high blood glucose value after a type of anaerobic exercise can be deceptive. Therefore, higher consumption of CHO or decreased insulin dose can prevent such hypoglycemia [49].
\nAn ergonomic aid is a product that contains a nutrient or a group of nutrients that improve the SP without taking into account the harmful effects in athletes, while a supplement is a nutritional aid to complete the diet associated with the practice of physical exercise [50].
\nWhen an athlete seeks to improve in the SP, his ability to tolerate intense workouts and hard competitions is crucial to avoid falling into injury or chronic fatigue. To achieve this purpose, an adequate supply of nutrients is essential. However, many times this does not happen, and the use of dietary supplements is resorted to [50].
\nThese supplements must be prescribed individually according to the needs of each person (sex, age, fitness, intensity and duration of the exercise, season, etc.), in order to maintain both the state of health and the improvement of the SP. Dietary supplements must offer maximum possible safety and have a degree of scientific evidence to support their effect [50].
\nCurrently between 40 and 70% of athletes make use of supplements without previously analyzing if necessary. In addition, a large number of sports supplements have not shown empirical evidence to improve SP. Likewise, there is a certain legal vacuum with the labeling of these substances, where 80% of these products do not contain the quantities declared on the label. In addition, 10–15% of these contain prohibited substances, and this can generate a high risk of committing an offense involuntarily by the athlete [51].
\nAccording to the Australian Institute of Sport, supplements are classified into four groups, based on effectiveness and safety [52]:
Group A: based on the evidence. Recommended for athletes.
Useful and timely source of energy or nutrients in the diet of athlete
Scientifically proven their evidence for the improvement of the SP, when they are used with a protocol and specific situation
In this group we can find:
Food for athletes (gels, bars, electrolytes, isotonic drinks, maltodextrins, whey protein)
Medical supplements (vitamin D, probiotics, iron/calcium supplements)
Substances to improve SP (creatine monohydrate, caffeine, beta-alanine, bicarbonate, beet juice)
Group B: more research deserved and advised under research or monitoring protocol.
Some benefit in non-athlete population or have data that suggest possible benefit of SP.
Of particular interest to athletes and coaches.
In this group we can find (quercetin, HMB, glutamine, BCCA, CLA, carnitine).
Group C: few tests of beneficial effect are not provided to athletes.
Not proven improvement RD despite its widespread use.
Very little or no benefit, and sometimes they even affect the RD in a negative way.
In this group supplements of group A and B may be included when used without an individualized protocol and without a basis in scientific evidence.
Group D: should not be used by athletes.
Are prohibited or have risk of contamination with doping or positive substance by drug
In this group we can find glycerol, ephedrine, sibutramine, and tribulus terrestris.
\nDespite all this information, many athletes believe that supplements are the basis of the athlete’s diet and believe that without that supplement, they will not reach their maximum level. This belief is one of the biggest mistakes in the world of sports nutrition, where the basic diet that is the true pillar on which sports nutrition is based is neglected.
\nThe basis of sports nutrition is a varied diet and individually tailored to the requirements and appetency of each athlete. The athlete should be instructed about the importance of diet, called “invisible training,” which is not only important on competition day. Prior to establishing nutritional guidelines, it is necessary to know and adapt the BC of the athlete in the different periods of the season and make revisions through the sum of six skinfolds.
\nIt is necessary to know some physiology to know the different metabolic pathways that interact during the exercise. In this way depending on the type of sports performed, duration and intensity adapt dietary intake at expense. Macronutrient requirements will be established based on g/kg/BW. With respect to CHOs, recommendations vary between 3 and 12 g/kg/BW to avoid compromising the SP, and protein consumption can vary between 1.2 and 2.0 g/kg/BW, with the total daily intake being more important than the number of intakes. Regarding to fatty acids, quality will prevail, improving the inflammatory profile with an increase in the consumption of omega-3 compared to omega-6.
\nIt is essential to maintain a state of hydration before, during, and after exercise to avoid compromising SP, so it is necessary to instruct the athlete with proper hydration guidelines. It is advisable to train the digestive system during workouts, both for hydration and testing different CHOs doses. It is important not to try new patterns on the day of competition.
\n\n sports performance body composition body mass index dual-energy X-ray absorptiometry bioelectrical impedance analysis International Society for the Advancement of Kinanthropometry carbohydrates basal metabolic rate body weight amino acid mammalian target of rapamycin American College of Sports Medicine
IntechOpen aims to ensure that original material is published while at the same time giving significant freedom to our Authors. To that end we maintain a flexible Copyright Policy guaranteeing that there is no transfer of copyright to the publisher and Authors retain exclusive copyright to their Work.
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\\n\\n1. DEFINITIONS
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\\n\\nBook: The publication as a collection of chapters compiled by IntechOpen including the Chapter. Chapter: The original literary work created by Corresponding Author and any Co-Author that is the subject of this Agreement.
\\n\\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
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\\n\\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\\n\\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Chapter but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Chapter as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\\n\\nThe Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\\n\\nSubject to the license granted above, copyright in the Chapter and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\\n\\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Chapter.
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\\n\\n3. CORRESPONDING AUTHOR'S DUTIES
\\n\\n3.1 When distributing or re-publishing the Chapter, the Corresponding Author agrees to credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Chapter.
\\n\\n3.2 When submitting the Chapter, the Corresponding Author agrees to:
\\n\\nThe Corresponding Author will be held responsible for the payment of the Open Access Publishing Fees.
\\n\\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\\n\\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Chapter worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\\n\\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\\n\\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\\n\\n4. CORRESPONDING AUTHOR'S WARRANTY
\\n\\n4.1 The Corresponding Author represents and warrants that the Chapter does not and will not breach any applicable law or the rights of any third party and, specifically, that the Chapter contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Chapter is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Chapter has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\\n\\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Chapter to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Chapter was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Chapter on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\\n\\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\\n\\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\\n\\n5. TERMINATION
\\n\\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co-Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\\n\\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\\n\\n6. INTECHOPEN’S DUTIES AND RIGHTS
\\n\\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Chapter attributing it to the Corresponding Author and any Co-Author.
\\n\\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Chapter and has the right to contact the Corresponding Author and any Co-Author until the Chapter is publicly available on any platform owned and/or operated by IntechOpen.
\\n\\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Chapter, IntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\\n\\n7. MISCELLANEOUS
\\n\\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\\n\\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\\n\\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\\n\\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\\n\\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\\n\\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\\n\\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\\n\\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\\n\\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\\n\\nLast updated: 2020-11-27
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The Corresponding Author (acting on behalf of all Authors) and INTECHOPEN LIMITED, incorporated and registered in England and Wales with company number 11086078 and a registered office at 5 Princes Gate Court, London, United Kingdom, SW7 2QJ conclude the following Agreement regarding the publication of a Book Chapter:
\n\n1. DEFINITIONS
\n\nCorresponding Author: The Author of the Chapter who serves as a Signatory to this Agreement. The Corresponding Author acts on behalf of any other Co-Author.
\n\nCo-Author: All other Authors of the Chapter besides the Corresponding Author.
\n\nIntechOpen: IntechOpen Ltd., the Publisher of the Book.
\n\nBook: The publication as a collection of chapters compiled by IntechOpen including the Chapter. Chapter: The original literary work created by Corresponding Author and any Co-Author that is the subject of this Agreement.
\n\n2. CORRESPONDING AUTHOR'S GRANT OF RIGHTS
\n\n2.1 Subject to the following Article, the Corresponding Author grants and shall ensure that each Co-Author grants, to IntechOpen, during the full term of copyright and any extensions or renewals of that term the following:
\n\nThe aforementioned licenses shall survive the expiry or termination of this Agreement for any reason.
\n\n2.2 The Corresponding Author (on their own behalf and on behalf of any Co-Author) reserves the following rights to the Chapter but agrees not to exercise them in such a way as to adversely affect IntechOpen's ability to utilize the full benefit of this Publication Agreement: (i) reprographic rights worldwide, other than those which subsist in the typographical arrangement of the Chapter as published by IntechOpen; and (ii) public lending rights arising under the Public Lending Right Act 1979, as amended from time to time, and any similar rights arising in any part of the world.
\n\nThe Corresponding Author confirms that they (and any Co-Author) are and will remain a member of any applicable licensing and collecting society and any successor to that body responsible for administering royalties for the reprographic reproduction of copyright works.
\n\nSubject to the license granted above, copyright in the Chapter and all versions of it created during IntechOpen's editing process (including the published version) is retained by the Corresponding Author and any Co-Author.
\n\nSubject to the license granted above, the Corresponding Author and any Co-Author retains patent, trademark and other intellectual property rights to the Chapter.
\n\n2.3 All rights granted to IntechOpen in this Article are assignable, sublicensable or otherwise transferrable to third parties without the Corresponding Author's or any Co-Author’s specific approval.
\n\n2.4 The Corresponding Author (on their own behalf and on behalf of each Co-Author) will not assert any rights under the Copyright, Designs and Patents Act 1988 to object to derogatory treatment of the Chapter as a consequence of IntechOpen's changes to the Chapter arising from translation of it, corrections and edits for house style, removal of problematic material and other reasonable edits.
\n\n3. CORRESPONDING AUTHOR'S DUTIES
\n\n3.1 When distributing or re-publishing the Chapter, the Corresponding Author agrees to credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen. The Corresponding Author warrants that each Co-Author will also credit the Book in which the Chapter has been published as the source of first publication, as well as IntechOpen, when they are distributing or re-publishing the Chapter.
\n\n3.2 When submitting the Chapter, the Corresponding Author agrees to:
\n\nThe Corresponding Author will be held responsible for the payment of the Open Access Publishing Fees.
\n\nAll payments shall be due 30 days from the date of the issued invoice. The Corresponding Author or the payer on the Corresponding Author's and Co-Authors' behalf will bear all banking and similar charges incurred.
\n\n3.3 The Corresponding Author shall obtain in writing all consents necessary for the reproduction of any material in which a third-party right exists, including quotations, photographs and illustrations, in all editions of the Chapter worldwide for the full term of the above licenses, and shall provide to IntechOpen upon request the original copies of such consents for inspection (at IntechOpen's option) or photocopies of such consents.
\n\nThe Corresponding Author shall obtain written informed consent for publication from people who might recognize themselves or be identified by others (e.g. from case reports or photographs).
\n\n3.4 The Corresponding Author and any Co-Author shall respect confidentiality rights during and after the termination of this Agreement. The information contained in all correspondence and documents as part of the publishing activity between IntechOpen and the Corresponding Author and any Co-Author are confidential and are intended only for the recipient. The contents may not be disclosed publicly and are not intended for unauthorized use or distribution. Any use, disclosure, copying, or distribution is prohibited and may be unlawful.
\n\n4. CORRESPONDING AUTHOR'S WARRANTY
\n\n4.1 The Corresponding Author represents and warrants that the Chapter does not and will not breach any applicable law or the rights of any third party and, specifically, that the Chapter contains no matter that is defamatory or that infringes any literary or proprietary rights, intellectual property rights, or any rights of privacy. The Corresponding Author warrants and represents that: (i) the Chapter is the original work of themselves and any Co-Author and is not copied wholly or substantially from any other work or material or any other source; (ii) the Chapter has not been formally published in any other peer-reviewed journal or in a book or edited collection, and is not under consideration for any such publication; (iii) they themselves and any Co-Author are qualifying persons under section 154 of the Copyright, Designs and Patents Act 1988; (iv) they themselves and any Co-Author have not assigned and will not during the term of this Publication Agreement purport to assign any of the rights granted to IntechOpen under this Publication Agreement; and (v) the rights granted by this Publication Agreement are free from any security interest, option, mortgage, charge or lien.
\n\nThe Corresponding Author also warrants and represents that: (i) they have the full power to enter into this Publication Agreement on their own behalf and on behalf of each Co-Author; and (ii) they have the necessary rights and/or title in and to the Chapter to grant IntechOpen, on behalf of themselves and any Co-Author, the rights and licenses expressed to be granted in this Publication Agreement. If the Chapter was prepared jointly by the Corresponding Author and any Co-Author, the Corresponding Author warrants and represents that: (i) each Co-Author agrees to the submission, license and publication of the Chapter on the terms of this Publication Agreement; and (ii) they have the authority to enter into this Publication Agreement on behalf of and bind each Co-Author. The Corresponding Author shall: (i) ensure each Co-Author complies with all relevant provisions of this Publication Agreement, including those relating to confidentiality, performance and standards, as if a party to this Publication Agreement; and (ii) remain primarily liable for all acts and/or omissions of each such Co-Author.
\n\nThe Corresponding Author agrees to indemnify and hold IntechOpen harmless against all liabilities, costs, expenses, damages and losses and all reasonable legal costs and expenses suffered or incurred by IntechOpen arising out of or in connection with any breach of the aforementioned representations and warranties. This indemnity shall not cover IntechOpen to the extent that a claim under it results from IntechOpen's negligence or willful misconduct.
\n\n4.2 Nothing in this Publication Agreement shall have the effect of excluding or limiting any liability for death or personal injury caused by negligence or any other liability that cannot be excluded or limited by applicable law.
\n\n5. TERMINATION
\n\n5.1 IntechOpen has a right to terminate this Publication Agreement for quality, program, technical or other reasons with immediate effect, including without limitation (i) if the Corresponding Author or any Co-Author commits a material breach of this Publication Agreement; (ii) if the Corresponding Author or any Co-Author (being an individual) is the subject of a bankruptcy petition, application or order; or (iii) if the Corresponding Author or any Co-Author (being a company) commences negotiations with all or any class of its creditors with a view to rescheduling any of its debts, or makes a proposal for or enters into any compromise or arrangement with any of its creditors.
\n\nIn case of termination, IntechOpen will notify the Corresponding Author, in writing, of the decision.
\n\n6. INTECHOPEN’S DUTIES AND RIGHTS
\n\n6.1 Unless prevented from doing so by events outside its reasonable control, IntechOpen, in its discretion, agrees to publish the Chapter attributing it to the Corresponding Author and any Co-Author.
\n\n6.2 IntechOpen has the right to use the Corresponding Author’s and any Co-Author’s names and likeness in connection with scientific dissemination, retrieval, archiving, web hosting and promotion and marketing of the Chapter and has the right to contact the Corresponding Author and any Co-Author until the Chapter is publicly available on any platform owned and/or operated by IntechOpen.
\n\n6.3 IntechOpen is granted the authority to enforce the rights from this Publication Agreement, on behalf of the Corresponding Author and any Co-Author, against third parties (for example in cases of plagiarism or copyright infringements). In respect of any such infringement or suspected infringement of the copyright in the Chapter, IntechOpen shall have absolute discretion in addressing any such infringement which is likely to affect IntechOpen's rights under this Publication Agreement, including issuing and conducting proceedings against the suspected infringer.
\n\n7. MISCELLANEOUS
\n\n7.1 Further Assurance: The Corresponding Author shall and will ensure that any relevant third party (including any Co-Author) shall, execute and deliver whatever further documents or deeds and perform such acts as IntechOpen reasonably requires from time to time for the purpose of giving IntechOpen the full benefit of the provisions of this Publication Agreement.
\n\n7.2 Third Party Rights: A person who is not a party to this Publication Agreement may not enforce any of its provisions under the Contracts (Rights of Third Parties) Act 1999.
\n\n7.3 Entire Agreement: This Publication Agreement constitutes the entire agreement between the parties in relation to its subject matter. It replaces and extinguishes all prior agreements, draft agreements, arrangements, collateral warranties, collateral contracts, statements, assurances, representations and undertakings of any nature made by or on behalf of the parties, whether oral or written, in relation to that subject matter. Each party acknowledges that in entering into this Publication Agreement it has not relied upon any oral or written statements, collateral or other warranties, assurances, representations or undertakings which were made by or on behalf of the other party in relation to the subject matter of this Publication Agreement at any time before its signature (together "Pre-Contractual Statements"), other than those which are set out in this Publication Agreement. Each party hereby waives all rights and remedies which might otherwise be available to it in relation to such Pre-Contractual Statements. Nothing in this clause shall exclude or restrict the liability of either party arising out of its pre-contract fraudulent misrepresentation or fraudulent concealment.
\n\n7.4 Waiver: No failure or delay by a party to exercise any right or remedy provided under this Publication Agreement or by law shall constitute a waiver of that or any other right or remedy, nor shall it preclude or restrict the further exercise of that or any other right or remedy. No single or partial exercise of such right or remedy shall preclude or restrict the further exercise of that or any other right or remedy.
\n\n7.5 Variation: No variation of this Publication Agreement shall be effective unless it is in writing and signed by the parties (or their duly authorized representatives).
\n\n7.6 Severance: If any provision or part-provision of this Publication Agreement is or becomes invalid, illegal or unenforceable, it shall be deemed modified to the minimum extent necessary to make it valid, legal and enforceable. If such modification is not possible, the relevant provision or part-provision shall be deemed deleted.
\n\nAny modification to or deletion of a provision or part-provision under this clause shall not affect the validity and enforceability of the rest of this Publication Agreement.
\n\n7.7 No partnership: Nothing in this Publication Agreement is intended to, or shall be deemed to, establish or create any partnership or joint venture or the relationship of principal and agent or employer and employee between IntechOpen and the Corresponding Author or any Co-Author, nor authorize any party to make or enter into any commitments for or on behalf of any other party.
\n\n7.8 Governing law: This Publication Agreement and any dispute or claim (including non-contractual disputes or claims) arising out of or in connection with it or its subject matter or formation shall be governed by and construed in accordance with the law of England and Wales. The parties submit to the exclusive jurisdiction of the English courts to settle any dispute or claim arising out of or in connection with this Publication Agreement (including any non-contractual disputes or claims).
\n\nLast updated: 2020-11-27
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I am also a member of the team in charge for the supervision of Ph.D. students in the fields of development of silicon based planar waveguide sensor devices, study of inelastic electron tunnelling in planar tunnelling nanostructures for sensing applications and development of organotellurium(IV) compounds for semiconductor applications. I am a specialist in data analysis techniques and nanosurface structure. 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After obtaining a Master's degree in Mechanical Engineering, he continued his PhD studies in Robotics at the Vienna University of Technology. Here he worked as a robotic researcher with the university's Intelligent Manufacturing Systems Group as well as a guest researcher at various European universities, including the Swiss Federal Institute of Technology Lausanne (EPFL). During this time he published more than 20 scientific papers, gave presentations, served as a reviewer for major robotic journals and conferences and most importantly he co-founded and built the International Journal of Advanced Robotic Systems- world's first Open Access journal in the field of robotics. Starting this journal was a pivotal point in his career, since it was a pathway to founding IntechOpen - Open Access publisher focused on addressing academic researchers needs. Alex is a personification of IntechOpen key values being trusted, open and entrepreneurial. Today his focus is on defining the growth and development strategy for the company.",institutionString:null,institution:{name:"TU Wien",country:{name:"Austria"}}},{id:"19816",title:"Prof.",name:"Alexander",middleName:null,surname:"Kokorin",slug:"alexander-kokorin",fullName:"Alexander Kokorin",position:null,profilePictureURL:"https://mts.intechopen.com/storage/users/19816/images/1607_n.jpg",biography:"Alexander I. Kokorin: born: 1947, Moscow; DSc., PhD; Principal Research Fellow (Research Professor) of Department of Kinetics and Catalysis, N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow.\r\nArea of research interests: physical chemistry of complex-organized molecular and nanosized systems, including polymer-metal complexes; the surface of doped oxide semiconductors. 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