Open access peer-reviewed Edited Volume


Preclinical, Clinical and Translational Aspects

Edited by Berend Olivier

Utrecht University

Major depression is a severe and prevalent brain disorder with a high disability burden, hence the push for effective treatments. Antidepressants have been around since the 1950s, and although current medications are much more effective than early ones, there is still much room for improvement. "Real" antidepressants, defined as those that "repair" or "improve" the depression-causing mechanism in the brains of depressed patients, have yet to be identified. This book presents current research on depression and antidepressants, including use of antidepressants in alcohol use disorders and pregnancy, treatment-resistant depression, and development of potential new medications.

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AntidepressantsPreclinical, Clinical and Translational AspectsEdited by Berend Olivier

Published: November 20th 2019

DOI: 10.5772/intechopen.73911

ISBN: 978-1-78985-277-6

Print ISBN: 978-1-78985-266-0

eBook (PDF) ISBN: 978-1-78985-278-3

Copyright year: 2019

Books open for chapter submissions

1754 Total Chapter Downloads

1 Crossref Citations

2 Dimensions Citations


Open access peer-reviewed

1. Introductory Chapter: Antidepressants - Preclinical, Clinical and Translational Aspects

By Berend Olivier


Open access peer-reviewed

2. Rethinking the Use of Antidepressants to Treat Alcohol Use Disorders and Depression Comorbidity: The Role of Neurogenesis

By Antonio Ballesta, Francisco Alén, Fernando Rodríguez de Fonseca, Raquel Gómez de Heras and Laura Orio


Open access peer-reviewed

3. Resistant Depression

By Jose Alfonso Ontiveros


Open access peer-reviewed

4. Influences of Maternal Vulnerability and Antidepressant Treatment during Pregnancy on the Developing Offspring

By Laura Staal and Jocelien DA Olivier


Open access peer-reviewed

5. Orexin 2 Receptor Antagonists from Prefrontal Cortical Circuitry to Rodent Behavioral Screens

By Gerard J. Marek, Stephen Chaney and Mark J. Benvenga


Open access peer-reviewed

6. The BDNF Loop 4 Dipeptide Mimetic Bis(N-monosuccinyl-L-seryl-L-lysine)hexamethylenediamide Is Active in a Depression Model in Mice after Acute Oral Administration

By Polina Povarnina, Yulia N. Firsova, Anna V. Tallerova, Аrmen G. Mezhlumyan, Sergey V. Kruglov, Tatiana A. Antipova, Tatiana A. Gudasheva and Sergey B. Seredenin


Edited Volume and chapters are indexed in

  • Worldcat
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  • AZ ebsco
  • Base
  • CNKI

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