Open access peer-reviewed Edited Volume

Advances in the Preclinical Study of Ischemic Stroke

Edited by Maurizio Balestrino

University of Genoa, Italy

This book reports innovations in the preclinical study of stroke, including - novel tools and findings in animal models of stroke, - novel biochemical mechanisms through which ischemic damage may be both generated and limited, - novel pathways to neuroprotection. Although hypothermia has been so far the sole "neuroprotection" treatment that has survived the translation from preclinical to clinical studies, progress in both preclinical studies and in the design of clinical trials will hopefully provide more and better treatments for ischemic stroke. This book aims at providing the preclinical scientist with innovative knowledge and tools to investigate novel mechanisms of, and treatments for, ischemic brain damage.

Read more >Order hardcopy
Advances in the Preclinical Study of Ischemic StrokeEdited by Maurizio Balestrino

Published: March 16th 2012

DOI: 10.5772/1082

ISBN: 978-953-51-0290-8

eBook (PDF) ISBN: 978-953-51-5240-8

Copyright year: 2012

Books open for chapter submissions

47087 Total Chapter Downloads

21 Crossref Citations

24 Web of Science Citations

38 Dimensions Citations


Open access peer-reviewed

1. Ischemic Neurodegeneration in Stroke-Prone Spontaneously Hypertensive Rats and Its Prevention with Antioxidants Such as Polyphenols

By Kazuo Yamagata


Open access peer-reviewed

2. Frameless Stereotaxy in Sheep - Neurosurgical and Imaging Techniques for Translational Stroke Research

By Antje Dreyer, Albrecht Stroh, Claudia Pösel, Matthias Findeisen, Teresa von Geymüller, Donald Lobsien, Björn Nitzsche and Johannes Boltze


Open access peer-reviewed

3. A Master Key to Assess Stroke Consequences Across Species: The Adhesive Removal Test

By Valentine Bouet and Thomas Freret


Open access peer-reviewed

4. Variations in Origin of Arteries Supplying the Brain in Rabbit and Their Impact on Total Cerebral Ischemia

By David Mazensky, Jan Danko, Emil Pilipcinec, Eva Petrovova and Lenka Luptakova


Open access peer-reviewed

5. Cerebral Ischemia Induced Proteomic Alterations: Consequences for the Synapse and Organelles

By Willard J. Costain, Arsalan S. Haqqani, Ingrid Rasquinha, Marie-Soleil Giguere and Jacqueline Slinn


Open access peer-reviewed

6. Delayed Neuronal Death in Ischemic Stroke: Molecular Pathways

By Victor Li, Xiaoying Bi, Paul Szelemej and Jiming Kong


Open access peer-reviewed

7. The Matrix Metalloproteinases and Cerebral Ischemia

By Wan Yang and Guangqin Li


Open access peer-reviewed

8. Folate Deficiency Enhances Delayed Neuronal Death in the Hippocampus After Transient Cerebral Ischemia

By Jun Hyun Yoo


Open access peer-reviewed

9. Glial Cells, Inflammation and Heat Shock Proteins in Cerebral Ischemia

By Vivianne L. Tawfik, Robin E. White and Rona Giffard


Open access peer-reviewed

10. Role of Creatine Kinase – Hexokinase Complex in the Migration of Adenine Nucleotides in Mitochondrial Dysfunction

By Elena Erlykina and Tatiana Sergeeva


Open access peer-reviewed

11. Diabetes-Mediated Exacerbation of Neuronal Damage and Inflammation After Cerebral Ischemia in Rat: Protective Effects of Water-Soluble Extract from Culture Medium of Ganoderma lucidum Mycelia

By Naohiro Iwata, Mari Okazaki, Rika Nakano, Chisato Kasahara, Shinya Kamiuchi, Fumiko Suzuki, Hiroshi Iizuka, Hirokazu Matsuzaki and Yasuhide Hibino


Open access peer-reviewed

12. Mechanisms of Ischemic Induced Neuronal Death and Ischemic Tolerance

By Jan Lehotsky, Martina Pavlikova, Stanislav Straka, Maria Kovalska, Peter Kaplan and Zuzana Tatarkova


Open access peer-reviewed

13. Mitochondrial Ceramide in Stroke

By Tatyana I. Gudz and Sergei A. Novgorodov


Open access peer-reviewed

14. Neuroprotection in Animal Models of Global Cerebral Ischemia

By Miguel Cervantes, Ignacio González-Burgos, Graciela Letechipía-Vallejo, María Esther Olvera-Cortés and Gabriela Moralí


Open access peer-reviewed

15. Nrf2 Activation, an Innovative Therapeutic Alternative in Cerebral Ischemia

By Carlos Silva-Islas, Ricardo A. Santana, Ana L. Colín-González and Perla D. Maldonado


Open access peer-reviewed

16. Preconditioning and Postconditioning

By Joseph T. McCabe, Michael W. Bentley and Joseph C. O’Sullivan


Open access peer-reviewed

17. Could Mannitol-Induced Delay of Anoxic Depolarization be Relevant in Stroke Patients?

By Maurizio Balestrino, Enrico Adriano and Patrizia Garbati


Open access peer-reviewed

18. Fasudil (a Rho Kinase Inhibitor) Specifically Increases Cerebral Blood Flow in Area of Vasospasm After Subarachnoid Hemorrhage

By Masato Shibuya, Kenko Meda and Akira Ikeda


Open access peer-reviewed

19. Endogenous Agents That Contribute to Generate or Prevent Ischemic Damage

By Ornella Piazza and Giuliana Scarpati


Open access peer-reviewed

20. Time-Window of Progesterone Neuroprotection After Stroke and Its Underlying Molecular Mechanisms

By Weiyan Cai, Masahiro Sokabe and Ling Chen


Open access peer-reviewed

21. The Na+/H+ Exchanger-1 as a New Molecular Target in Stroke Interventions

By Vishal Chanana, Dandan Sun and Peter Ferrazzano


Open access peer-reviewed

22. PPAR Agonism as New Pharmacological Approach to the Management of Acute Ischemic Stroke

By Elisa Benetti, Nimesh Patel and Massimo Collino


Edited Volume and chapters are indexed in

  • Worldcat
  • OpenAIRE
  • Google Scholar
  • AZ ebsco
  • Base
  • CNKI

Order a hardcopy of the Edited Volume

Free shipping with DHL Express

Hardcover (ex. VAT)£159

Order now

Residents of European Union countries need to add a Book Value-Added Tax of 5%. Institutions and companies, registered as VAT taxable entities in their own EU member state, will not pay VAT by providing IntechOpen with their VAT registration number. This is made possible by the EU reverse charge method.

Special discount for IntechOpen contributors

All IntechOpen contributors are offered special discounts starting at 40% OFF available through your personal dashboard

Login and purchase