Prof. Reinhart Grundmann

Kreiskliniken, Germany

Dr. Reinhart T. Grundmann works currently as an independent medical expert. He is a professor of surgery at the University of Cologne and he has the qualification of general and vascular surgery. He is the former medical director of the B.Braun company, one of the leading providers of healthcare solutions. In the last eight years he has been working as the medical director of the Clinics Altotting-Burghausen, Germany. Dr. Grundmann was from 1992 until 2008 the managing director of the Zentralblatt fur Chirurgie and he is currently a member of the Editorial Board of World Journal of Gastrointestinal Surgery. He edited from 2001 to 2005 the Jahrbuch der Chirurgie- the book which provides an information on the latest developments in surgery. Dr. Grundmann already published more than 260 scientific publications, including books and the book chapters. His recent research interests lie in the field of efficiency and efectiveness in surgery. In this frame, he published a workflows on liver surgery, gastric cancer, obesity surgery and surgery for abdominal and carotide artery stenosis treatment.

Experience

Education

  • 1969 – 1973

    Medicine, University, Munich

    Surgery

  • 1974 – 1988

    Medicine, University, Cologne

    Surgery

Edited Books

  • Etiology, Pathogenesis and Pathophysiology of Aortic Aneurysms and Aneurysm Rupture

    This book considers mainly etiology, pathogenesis, and pathophysiology of aortic aneurysms (AA) and aneurysm rupture and addresses anyone engaged in treatment and prevention of AA. Multiple factors are implicated in AA pathogenesis, and are outlined here in detail by a team of specialist researchers. Initial pathological events in AA involve recruitment and infiltration of leukocytes into the aortic adventitia and media, which are associated with the production of inflammatory cytokines, chemokine, and reactive oxygen species. AA development is characterized by elastin fragmentation. As the aorta dilates due to loss of elastin and attenuation of the media, the arterial wall thickens as a result of remodeling. Collagen synthesis increases during the early stages of aneurysm formation, suggesting a repair process, but resulting in a less distensible vessel. Proteases identified in excess in AA and other aortic diseases include matrix metalloproteinases (MMPs), cathepsins, chymase and others. The elucidation of these issues will identify new targets for prophylactic and therapeutic intervention.

  • Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms

    This book considers mainly diagnosis, screening, surveillance and treatment of abdominal, thoracoabdominal and thoracic aortic aneurysms. It addresses vascular and cardiothoracic surgeons and interventional radiologists, but also anyone engaged in vascular medicine. The high mortality of ruptured aneurysms certainly favors the recommendation of prophylactic repair of asymptomatic aortic aneurysms (AA) and therewith a generous screening. However, the comorbidities of these patients and their age have to be kept in mind if the efficacy and cost effectiveness of screening and prophylactic surgery should not be overestimated. The treatment recommendations which will be outlined here, have to regard on the one hand the natural course of the disease, the risk of rupture, and the life expectancy of the patient, and on the other hand the morbidity and mortality of the prophylactic surgical intervention. The book describes perioperative mortality after endovascular and open repair of AA, long-term outcome after repair, and the cost-effectiveness of treatment.

  • Diagnosis and Treatment of Abdominal and Thoracic Aortic Aneurysms Including the Ascending Aorta and the Aortic Arch

    This book considers diagnosis and treatment of abdominal and thoracic aortic aneurysms. It addresses vascular and cardiothoracic surgeons and interventional radiologists, but also anyone engaged in vascular medicine. The book focuses amongst other things on operations in the ascending aorta and the aortic arch. Surgical procedures in this area have received increasing attention in the last few years and have been subjected to several modifications. Especially the development of interventional radiological endovascular techniques that reduce the invasive nature of surgery as well as complication rates led to rapid advancements. Thoracoabdominal aortic aneurysm (TAAA) repair still remains a challenging operation since it necessitates extended exposure of the aorta and reimplantation of the vital aortic branches. Among possible postoperative complications, spinal cord injury (SCI) seems one of the most formidable morbidities. Strategies for TAAA repair and the best and most reasonable approach to prevent SCI after TAAA repair are presented.

Publications