Pharmacology, Toxicology and Pharmaceutical Science » Pharmacology

Topics on Drug Metabolism

Edited by James Paxton, ISBN 978-953-51-0099-7, 306 pages, Publisher: InTech, Chapters published February 22, 2012 under CC BY 3.0 license
DOI: 10.5772/1180
Edited Volume

In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.

Thomson Reuters' Book Citation Index
This book is indexed in the Book Citation Index in Web of Science™ Core Collection (BKCI) and BIOSIS Previews. BKCI is part of the Web of Science Core Collection (WoSCC) together with SCI Expanded, SSCI, AHCI and other databases.