Health Sciences > Pharmacology, Toxicology and Pharmaceutical Science

Drug Discovery and Development - Present and Future

Edited by: Izet M. Kapetanovic

ISBN 978-953-307-615-7, Hard cover, 528 pages
Publisher: InTech
Publication date: December 2011
Subject: Pharmacology, Toxicology and Pharmaceutical Science

Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.

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Table of Contents

1. Overview of Current Drug Discovery and Development with an Eye towards the Future
   Izet M. Kapetanovic
   193 views, 89 downloads
   
2. Drug Discovery and Ayurveda: Win-Win Relationship Between Contemporary and Ancient Sciences
   Bhushan Patwardhan and Kapil Khambholja
   503 views, 204 downloads
   
3. Evolutionary Biology and Drug Development
   Pierre M. Durand and Theresa L. Coetzer
   370 views, 133 downloads
   
4. Novel Oncology Drug Development Strategies in the Era of Personalised Medicine
   C.R. Lemech, R.S. Kristeleit and H.T. Arkenau
   124 views, 60 downloads
   
5. Drug Discovery into the 21st Century
   Klaus Pors
   242 views, 203 downloads
   
6. Genetically Engineered Mouse Models in Preclinical Anti-Cancer Drug Development
   Sergio Y. Alcoser and Melinda G. Hollingshead
   176 views, 107 downloads
   
7. Genetic Pharmacotherapy
   Celia Gellman, Susana Mingote, Yvonne Wang, Inna Gaisler-Salomon and Stephen Rayport
   110 views, 53 downloads
   
8. Critical Human Hepatocyte-Based In Vitro Assays for the Evaluation of Adverse Drug Effects
   Albert P. Li
   97 views, 73 downloads
   
9. The Use of In Vitro 3D Cell Models in Drug Development for Respiratory Diseases
   Song Huang, Ludovic Wiszniewski and Samuel Constant
   136 views, 84 downloads
   
10. Chemical Biology: What is Its Role in Drug Discovery?
    Lisa Pirrie and Nicholas J. Westwood
    161 views, 103 downloads
    
11. Towards Understanding Drugs on the Molecular Level to Design Drugs of Desired Profiles
    Jolanta Natalia Latosińska and Magdalena Latosińska
    124 views, 69 downloads
    
12. De-Risking Drug Discovery Programmes Early with ADMET
    Katya Tsaioun and Steven A. Kates
    122 views, 62 downloads
    
13. Novel Approach to High Throughput Screening for Activators of Transcription Factors
    Natalya Smirnova, Dmitry Hushpulian, Rajiv Ratan and Irina Gazaryan
    158 views, 63 downloads
    
14. Assessment of Cell Cycle Inhibitors by Flow Cytometry
    Paolo Cappella and Jürgen Moll
    150 views, 62 downloads
    
15. Image-Based High-Content Screening in Drug Discovery
    Marjo Götte and Daniela Gabriel
    110 views, 73 downloads
    
16. Recent Advances in Biotherapeutics Drug Discovery and Development
    Xiaotian Zhong, Peter Neumann, Michael Corbo and Evan Loh
    135 views, 136 downloads
    
17. Drug Discovery by Aptamers in Protozoan Infectious Diseases
    Carsten Wrenger and Henning Ulrich
    124 views, 53 downloads
    
18. Streamlining ICH Q6B Analytical Testing of Biotherapeutics
    Elizabeth Higgins, Elisabeth Kast and Amy Lachapelle
    187 views, 80 downloads
    
19. Biomarkers in Drug Development: A Useful Tool but Discrepant Results May Have a Major Impact
    Abdel-Baset Halim
    137 views, 79 downloads
    
20. Nanotechnology Based Targeted Drug Delivery: Current Status and Future Prospects for Drug Development
    Sadhna Sharma and Amandeep Singh
    169 views, 191 downloads
    
21. Silver Nanoparticles – Universal Multifunctional Nanoparticles for Bio Sensing, Imaging for Diagnostics and Targeted Drug Delivery for Therapeutic Applications
    Anitha Sironmani and Kiruba Daniel
    172 views, 276 downloads
    
22. Mesenchymal Stem Cells as Vehicles for Targeted Therapies
    Gabriele Putz Todd, Michelle A LeRoux and Alla Danilkovitch-Miagkova
    132 views, 91 downloads