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Medicine » Mental and Behavioural Disorders and Diseases of the Nervous System » "Anxiety and Related Disorders", book edited by Ágnes Szirmai, ISBN 978-953-307-254-8, Published: August 29, 2011 under CC BY-NC-SA 3.0 license. © The Author(s).

Chapter 7

Generalised Anxiety Disorder, Mortality and Disease: A Stronger Predictor than Major Depressive Disorder

By Anna C. Phillips
DOI: 10.5772/19467

  1. D. K. Ahern, L. Gorkin, J. L. Anderson, C. Tierney, A. Hallstrom, C. Ewart, et al.1990Biobehavioral variables and mortality or cardiac arrest in the Cardiac Arrhythmia Pilot Study (CAPS). American Journal of Cardiology, 665962

  2. American Psychiatric Association,1980Diagnostic and statistical manual of mental disorders (3rd. edition). American Psychiatric Association, Washington DC.

  3. G. D. Batty, M. J. Shipley, L. Mortensen, S. H. Boyle, J. Barefoot, M. Grønbaek, et al.2008IQ in late adolescence/early adulthood, risk factors in middle-age, and later all-cause mortality in men: the Vietnam Experience Study. Journal of Epidemiology and Community Health, 62522531

  4. L. J. Beilin, 1987Epidemiology of alcohol and hypertension. Adv Alcohol Subst Abuse, 669 EOF87 EOF

  5. J. A. Boscarino, 1997Diseases among men 20 years after exposure to severe stress: implications for clinical research and medical care. Psychosomatic Medicine, 59605614

  6. J. A. Boscarino, 2004Posttraumatic stress disorder and physical illness: results from clinical and epidemiologic studies. Annals of the New York Academy of Sciences, 1032141153

  7. J. A. Boscarino, 2006aExternal-cause mortality after psychologic trauma: the effects of stress exposure and predisposition. Comparative Psychiatry, 47503514

  8. J. A. Boscarino, 2006bPosttraumatic stress disorder and mortality among U.S. Army veterans 30 years after military service. Annals of Epidemiology, 16248256

  9. J. A. Boscarino, J. Chang, 1999Higher abnormal leukocyte and lymphocyte counts 20 years after exposure to severe stress: research and clinical implications. Psychosomatic Medicine, 61378386

  10. E. S. Brown, F. P. Varghese, B. S. Mc Ewen, 2004Association of depression with medical illness: does cortisol play a role? Biological Psychiatry, 5519

  11. J. R. Chiong, 2008Controlling hypertension from a public health perspective. International Journal of Cardiology, 127151156

  12. H. M. Colhoun, H. Hemingway, N. R. Poulter, 1998Socio-economic status and blood pressure: an overview analysis. Journal of Human Hypertension, 1291110

  13. J. Denollet, D. L. Brutsaert, 1998Personality, disease severity, and the risk of long-term cardiac events in patients with a decreased ejection fraction after myocardial infarction. Circulation, 97167173

  14. B. P. Dohrenwend, J. B. Turner, N. A. Turse, B. G. Adams, K. C. Koenen, R. Marshall, 2006The psychological risks of Vietnam for U.S. veterans: a revisit with new data and methods. Science,313979982

  15. B. P. Dohrenwend, J. B. Turner, N. A. Turse, B. G. Adams, K. C. Koenen, R. Marshall, 2007Continuing controversy over the psychological risks of Vietnam for U.S. veterans. Journal of Trauma and Stress, 20449465

  16. J. A. Dunbar, P. Reddy, N. Davis-Lameloise, B. Philpot, T. Laatikainen, A. Kilkkinen, et al.2008Depression: an important co morbidity with metabolic syndrome in a general population. Diabetes Care, 3123682373

  17. E. D. Eaker, L. M. Sullivan, M. Kelly-Hayes, R. B. D’Agostino, Sr , E. J. Benjamin, 2005Tension and anxiety and the prediction of the 10-year incidence of coronary heart disease, atrial fibrillation, and total mortality: the Framingham Offspring Study. Psychosomatic Medicine, 67692696

  18. N. Frasure-Smith, F. Lesperance, 2003Depression and other psychological risks following myocardial infarction. Archives of General Psychiatry, 60627 EOF36 EOF

  19. N. Frasure-Smith, F. Lesperance, M. Talajic, 1995The impact of negative emotions on prognosis following myocardial infarction: is it more than depression? Health Psychology, 14

  20. K. M. Gaylord, 2006The psychosocial effects of combat: the frequently unseen injury. Critical Care Nursing Clinician North America, 18349357

  21. E. M. Goldbacher, K. A. Matthews, 2007Are psychological characteristics related to risk of the metabolic syndrome? A review of the literature. Annals of Behavioral Medicine, 34240 EOF252 EOF

  22. M. S. Green, E. Jucha, Y. Luz, 1986Blood pressure in smokers and nonsmokers: epidemiologic findings. American Heart Journal, 111932940

  23. A. P. Haines, J. D. Imeson, T. W. Meade, 1987Phobic anxiety and ischaemic heart disease. BMJ, 295297299

  24. T. Hallstrom, L. Lapidus, C. Bengtsson, K. Edstrom, 1986Psychosocial factors and risk of ischaemic heart disease and death in women: a twelve-year follow-up of participants in the population study of women in Gothenburg, Sweden. Journal of Psychosomatic Research, 30451459

  25. C. S. Hankin, A. Spiro, D. R. 3rd Miller, L. Kazis, 1999Mental disorders and mental health treatment among U.S. Department of Veterans Affairs outpatients: the Veterans Health Study. American Journal of Psychiatry, 15619241930

  26. T. H. Heiskanen, L. K. Niskanen, J. J. Hintikka, H. T. Koivumaa-Honkanen, K. M. Honkalampi, K. M. Haatainen, et al.2006Metabolic syndrome and depression: a cross-sectional analysis. Journal of Clinical Psychiatry, 67, 14221427

  27. C. Herrmann, S. Brand-Driehorst, B. Kaminsky, E. Leibing, H. Staats, U. Ruger, 1998Diagnostic groups and depressed mood as predictors of 22-month mortality in medical inpatients.Psychosomatic Medicine60570577

  28. A. Herva, P. Rasanen, J. Miettunen, M. Timonen, K. Laksy, J. Veijola, et al.2006Co-occurrence of metabolic syndrome with depression and anxiety in young adults: the Northern Finland 1966 Birth Cohort Study. Psychosomatic Medicine, 68213216

  29. C. W. Hoge, J. L. Auchterlonie, C. S. Milliken, 2006Mental health problems, use of mental health services, and attrition from military service after returning from deployment to Iraq or Afghanistan. Journal of the American Medical Association, 29510231032

  30. C. W. Hoge, C. A. Castro, S. C. Messer, D. Mc Gurk, D. I. Cotting, R. L. Koffman, 2004Combat duty in Iraq and Afghanistan, mental health problems, and barriers to care. New England Journal of Medicine, 3511322

  31. T. J. Holwerda, R. A. Schoevers, J. Dekker, D. J. Deeg, C. Jonker, A. T. Beekman, 2007The relationship between generalized anxiety disorder, depression and mortality in old age. International Journal of Geriatric Psychiatry, 22241249

  32. B. Isomaa, P. Almgren, T. Tuomi, B. Forsen, K. Lahti, M. Nissen, et al.2001Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care, 24683689

  33. J. R. Jennings, M. F. Muldoon, M. Hall, D. J. Buysse, S. B. Manuck, 2007Self-reported sleep quality is associated with the metabolic syndrome. Sleep, 30219223

  34. B. S. Jonas, P. Franks, D. D. Ingram, 1997Are symptoms of anxiety and depression risk factors for hypertension? Longitudinal evidence from the National Health and Nutrition Examination Survey I Epidemiologic Follow-up Study. Archives of Family Medicine, 64349

  35. R. C. Kessler, P. Berglund, O. Demler, R. Jin, K. R. Merikangas, E. E. Walters, 2005Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry, 62593602

  36. R. C. Kessler, W. T. Chiu, O. Demler, K. R. Merikangas, E. E. Walters, 2005Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry,, 62617627

  37. R. C. Kessler, Pont. R. L. Du, P. Berglund, H. U. Wittchen, 1999Impairment in pure and comorbid generalized anxiety disorder and major depression at 12 months in two national surveys. American Journal of Psychiatry, 15619151923

  38. L. S. Kinder, K. A. Bradley, W. J. Katon, E. Ludman, M. B. Mc Donell, C. L. Bryson, 2008Depression, posttraumatic stress disorder, and mortality. Psychosomatic Medicine, 70

  39. L. S. Kinder, M. R. Carnethon, L. P. Palaniappan, A. C. King, S. P. Fortmann, 2004Depression and the metabolic syndrome in young adults: findings from the Third National Health and Nutrition Examination Survey. Psychosomatic Medicine, 66316322

  40. H. Koponen, J. Jokelainen, S. Keinanen-Kiukaanniemi, E. Kumpusalo, M. Vanhala, 2008Metabolic syndrome predisposes to depressive symptoms: a population-based 7-year follow-up study. Journal of Clinical Psychiatry, 69178182

  41. H. M. Lakka, D. E. Laaksonen, T. A. Lakka, L. K. Niskanen, E. Kumpusalo, J. Tuomilehto, et al.2002The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. Journal of the American Medical Association, 28827092716

  42. D. Lane, D. Carroll, C. Ring, D. G. Beevers, G. Y. Lip, 2001Mortality and quality of life 12 months after myocardial infarction: effects of depression and anxiety. Psychosomatic Medicine, 63221230

  43. J. H. Markovitz, K. A. Matthews, W. B. Kannel, J. L. Cobb, R. B. D’Agostino, 1993Psychological predictors of hypertension in the Framingham Study. Is there tension in hypertension? Journal of the American Medical Association, 27024392443

  44. J. M. Mc Caffery, R. Niaura, J. F. Todaro, G. E. Swan, D. Carmelli, 2003Depressive symptoms and metabolic risk in adult male twins enrolled in the National Heart, Lung, and Blood Institute twin study. Psychosomatic Medicine, 65490497

  45. J. M. Murphy, R. R. Monson, D. C. Olivier, A. M. Sobol, A. H. Leighton, 1987Affective disorders and mortality. A general population study. Archives of General Psychiatry, 44473480

  46. D. L. Musselman, D. L. Evans, C. B. Nemeroff, 1998The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment. Archives of General Psychiatry, 55580592

  47. D. A. O’Leary, A. S. Lee, 1996Seven year prognosis in depression. Mortality and readmission risk in the Nottingham ECT cohort. British Journal of Psychiatry, 169423429

  48. U. Osby, L. Brandt, N. Correia, A. Ekbom, P. Sparen, 2001Excess mortality in bipolar and unipolar disorder in Sweden. Archives of General Psychiatry, 58844850

  49. S. B. Patten, C. A. Beck, A. Kassam, J. V. Williams, C. Barbui, L. M. Metz, 2005Long-term medical conditions and major depression: strength of association for specific conditions in the general population. Canadian Journal of Psychiatry, 50195202

  50. S. B. Patten, J. V. Williams, D. H. Lavorato, N. R. Campbell, M. Eliasziw, T. S. Campbell, 2009Major depression as a risk factor for high blood pressure: epidemiologic evidence from a national longitudinal study. Psychosomatic Medicine, 71273279

  51. A. J. Pelle, Y. Y. Gidron, B. M. Szabo, J. Denollet, 2008Psychological predictors of prognosis in chronic heart failure. Journal of Cardiac Failure, 14341350

  52. M. Prince, V. Patel, S. Saxena, M. Maj, J. Maselko, M. R. Phillips, et al.2007No health without mental health. The Lancet, 370859877

  53. K. Raikkonen, K. A. Matthews, L. H. Kuller, 2002The relationship between psychological risk attributes and the metabolic syndrome in healthy women: antecedent or consequence? Metabolism, 5115731577

  54. K. Raikkonen, K. A. Matthews, L. H. Kuller, 2007Depressive symptoms and stressful life events predict metabolic syndrome among middle-aged women: a comparison of World Health Organization, Adult Treatment Panel III, and International Diabetes Foundation definitions. Diabetes Care, 30872877

  55. R. R. Reeves, J. D. Parker, D. J. Konkle-Parker, 2005War-related mental health problems of today’s veterans: new clinical awareness. Journal of Psychosocial Nursing and Mental Health Services, 431828

  56. J. H. Riskind, A. T. Beck, R. J. Berchick, G. Brown, R. A. Steer, 1987Reliability of DSM-III diagnoses for major depression and generalized anxiety disorder using the structured clinical interview for DSM-III. Archives of General Psychiatry, 44817820

  57. L. Robins, J. Helzer, L. Cottler, 1987Diagnostic Interview Schedule (version III-A) Training Manual. Veterans Administration, St Louis.

  58. R. Rugulies, 2002Depression as a predictor for coronary heart disease. a review and meta-analysis. American Journal of Preventative Medicine, 235161

  59. J. Sareen, B. J. Cox, T. O. Afifi, M. B. Stein, S. L. Belik, G. Meadows, et al.2007Combat and peacekeeping operations in relation to prevalence of mental disorders and perceived need for mental health care: findings from a large representative sample of military personnel. Archives of General Psychiatry, 64843852

  60. L. Sevincok, A. Buyukozturk, F. Dereboy, 2001Serum lipid concentrations in patients with comorbid generalized anxiety disorder and major depressive disorder. Canadian Journal of Psychiatry, 466871

  61. M. R. Skilton, P. Moulin, J. L. Terra, F. Bonnet, 2007Associations between anxiety, depression, and the metabolic syndrome. Biological Psychiatry, 6212511257

  62. T. M. Spruill, T. G. Pickering, J. E. Schwartz, E. Mostofsky, G. Ogedegbe, L. Clemow, et al.2007The impact of perceived hypertension status on anxiety and the white coat effect. Annals of Behavioral Medicine, 3419

  63. T. W. Strine, A. H. Mokdad, S. R. Dube, L. S. Balluz, O. Gonzalez, J. T. Berry, et al.2008The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults. General Hospital Psychiatry, 30127137

  64. J. Suls, J. Bunde, 2005Anger, anxiety, and depression as risk factors for cardiovascular disease: the problems and implications of overlapping affective dispositions. Psychological Bulletin, 131260300

  65. P. G. Surtees, C. Barkley, 1994Future imperfect: the long-term outcome of depression. British Journal of Psychiatry, 164327341

  66. The Centers for Disease Control Vietnam Experience Study,1987Postservice mortality among Vietnam veterans. Journal of the American Medical Association, 257790795

  67. The Centers for Disease Control Vietnam Experience Study,1988aHealth status of Vietnam veterans. I. Psychosocial characteristics. Journal of the American Medical Association, 25927012707

  68. The Centers for Disease Control Vietnam Experience Study,1988bHealth status of Vietnam veterans. II. Physical Health. Journal of the American Medical Association, 25927082714

  69. F. Therrien, V. Drapeau, S. J. Lupien, S. Beaulieu, J. Dore, A. Tremblay, et al.2008Awakening cortisol response in relation to psychosocial profiles and eating behaviors. Physiology of Behavior, 93282288

  70. G. N. Thomas, C. M. Schooling, S. M. Mc Ghee, S. Y. Ho, B. M. Cheung, N. M. Wat, et al.2007Metabolic syndrome increases all-cause and vascular mortality: the Hong Kong Cardiovascular Risk Factor Study. Clinical Endocrinology, 66666671

  71. D. J. Torpy, N. Mullen, I. Ilias, L. K. Nieman, 2002Association of hypertension and hypokalemia with Cushing’s syndrome caused by ectopic ACTH secretion: a series of 58 cases. Annals of the New York Academy of Science, 970134144

  72. M. Trevisan, J. Liu, F. B. Bahsas, A. Menotti, 1998Syndrome X and mortality: a population-based study. Risk Factor and Life Expectancy Research Group. American Journal of Epidemiology, 148958 EOF66 EOF

  73. P. Tyrer, D. Baldwin, 2006Generalised anxiety disorder. The Lancet, 36821562166

  74. V. Vaccarino, C. Mc Clure, B. D. Johnson, D. S. Sheps, V. Bittner, T. Rutledge, et al.2008Depression, the metabolic syndrome and cardiovascular risk. Psychosomatic Medicine, 704048

  75. H. P. van Hout, A. T. Beekman, E. de Beurs, H. Comijs, H. van Marwijk, M. de Haan, et al.2004Anxiety and the risk of death in older men and women. British Journal of Psychiatry, 185399404

  76. T. Vogt, C. Pope, J. Mullooly, J. Hollis, 1994Mental health status as a predictor of morbidity and mortality: a 15-year follow-up of members of a health maintenance organization. American Journal of Public Health, 84227231

  77. M. M. Weissman, J. S. Markowitz, R. Ouellette, S. Greenwald, J. P. Kahn, 1990Panic disorder and cardiovascular/cerebrovascular problems: results from a community survey. American Journal of Psychiatry, 14715041508

  78. World Health Organisation,1992International Statistical Classification of Diseases and related health problems. WHO, Geneva.

  79. M. A. Whooley, C. M. Caska, B. E. Hendrickson, M. A. Rourke, J. Ho, S. Ali, 2007Depression and inflammation in patients with coronary heart disease: findings from the Heart and Soul Study. Biological Psychiatry, 62314320

  80. L. R. Wulsin, G. E. Vaillant, V. E. Wells, 1999A systematic review of the mortality of depression. Psychosomatic Medicine, 61617

  81. L. L. Yan, K. Liu, K. A. Matthews, M. L. Daviglus, T. F. Ferguson, C. I. Kiefe, 2003Psychosocial factors and risk of hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Journal of the American Medical Association, 29021382148