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Principles of Osteoarthritis- Its Definition, Character, Derivation and Modality-Related Recognition
Edited by Bruce M. Rothschild, ISBN 978-953-51-0063-8, Hard cover, 590 pages, Publisher: InTech, Published: February 22, 2012 under CC BY 3.0 license, in subject Immunology, Allergology and Rheumatology
DOI: 10.5772/1487
This volume addresses the nature of the most common form of arthritis in humans. If osteoarthritis is inevitable (only premature death prevents all of us from being afflicted), it seems essential to facilitate its recognition, prevention, options, and indications for treatment. Progress in understanding this disease has occurred with recognition that it is not simply a degenerative joint disease. Causative factors, such as joint malalignment, ligamentous abnormalities, overuse, and biomechanical and metabolic factors have been recognized as amenable to intervention; genetic factors, less so; with metabolic diseases, intermediate. Its diagnosis is based on recognition of overgrowth of bone at joint margins. This contrasts with overgrowth of bone at vertebral margins, which is not a symptomatic phenomenon and has been renamed spondylosis deformans. Osteoarthritis describes an abnormality of joints, but the severity does not necessarily produce pain. The patient and his/her symptoms need to be treated, not the x-ray.
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Book contents
- Chapter 1Epidemiology and Biomechanics of Osteoarthritis
- Chapter 2Symptoms, Signs and Quality of Life (QoL) in Osteoarthritis (OA)
- Chapter 3An Atlas-Based Approach to Study Morphological Differences in Human Femoral Cartilage Between Subjects from Incidence and Progression Cohorts: MRI Data from Osteoarthritis Initiative
- Chapter 4The Application of Imaging in Osteoarthritis
- Chapter 5Biomarkers and Ultrasound in the Knee Osteoarthrosis Diagnosis
- Chapter 6Biomechanics of Physiological and Pathological Bone Structures
- Chapter 7Subchondral Bone in Osteoarthritis
- Chapter 8The Relationship Between Gait Mechanics and Radiographic Disease Severity in Knee Osteoarthritis
- Chapter 9Osteoarthritis in Sports and Exercise: Risk Factors and Preventive Strategies
- Chapter 10Post-Traumatic Osteoarthritis: Biologic Approaches to Treatment
- Chapter 11The Genetics of Osteoarthritis
- Chapter 12Genetic Association and Linkage Studies in Osteoarthritis
- Chapter 13Genetic Mouse Models for Osteoarthritis Research
- Chapter 14Cartilage Extracellular Matrix Integrity and OA
- Chapter 15Biochemical Mediators Involved in Cartilage Degradation and the Induction of Pain in Osteoarthritis
- Chapter 16Proteases and Cartilage Degradation in Osteoarthritis
- Chapter 17Simple Method Using Gelatin-Coated Film for Comprehensively Assaying Gelatinase Activity in Synovial Fluid
- Chapter 18Toll-Like Receptors: At the Intersection of Osteoarthritis Pathology and Pain
- Chapter 19Anion Channels in Osteoarthritic Chondrocytes
- Chapter 20The Cholinergic System Can Be of Unexpected Importance in Osteoarthritis
- Chapter 21Transcriptional Regulation of Articular Chondrocyte Function and Its Implication in Osteoarthritis
- Chapter 22TGF-β Action in the Cartilage in Health and Disease
- Chapter 23How Important are Innate Immunity Cells in Osteoarthritis Pathology
- Chapter 24The Role of Synovial Macrophages and Macrophage-Produced Mediators in Driving Inflammatory and Destructive Responses in Osteoarthritis
- Chapter 25Cellular Physiology of Articular Cartilage in Health and Disease
