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Colorectal Cancer Biology - From Genes to Tumor
Edited by Rajunor Ettarh, ISBN 978-953-51-0062-1, Hard cover, 446 pages, Publisher: InTech, Published: February 10, 2012 under CC BY 3.0 license, in subject Oncology
DOI: 10.5772/1163
Colorectal cancer is a common disease, affecting millions worldwide and represents a global health problem. Effective therapeutic solutions and control measures for the disease will come from the collective research efforts of clinicians and scientists worldwide. This book presents the current status of the strides being made to understand the fundamental scientific basis of colorectal cancer. It provides contributions from scientists, clinicians and investigators from 20 different countries. The four sections of this volume examine the evidence and data in relation to genes and various polymorphisms, tumor microenvironment and infections associated with colorectal cancer. An increasingly better appreciation of the complex inter-connected basic biology of colorectal cancer will translate into effective measures for management and treatment of the disease. Research scientists and investigators as well as clinicians searching for a good understanding of the disease will find this book useful.
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Book contents
- Chapter 1Colorectal Cancer: It Starts and It Runs
- Chapter 2Germline Genetics in Colorectal Cancer Susceptibility and Prognosis
- Chapter 3The Role of Modifier Genes in Lynch Syndrome
- Chapter 4Cytokine Gene Polymorphisms in Colorectal Cancer
- Chapter 5Glutathione-S-Transferases in Development, Progression and Therapy of Colorectal Cancer
- Chapter 6Distinct Pathologic Roles for Glycogen Synthase Kinase 3β in Colorectal Cancer Progression
- Chapter 7Molecular Traits of the Budding Colorectal Cancer Cells
- Chapter 8Lipid Peroxidation in Colorectal Carcinogenesis: Bad and Good News
- Chapter 9Growth Factors and the Redox State as New Therapeutic Targets for Colorectal Cancer
- Chapter 10Human Tip60 (NuA4) Complex and Cancer
- Chapter 11Characterization of the Cell Membrane During Cancer Transformation
- Chapter 12Emergent Concepts from the Intestinal Guanylyl Cyclase C Pathway
- Chapter 13Molecular Mechanisms of Lymphatic Metastasis
- Chapter 14Modulation of Tumor Angiogenesis by a Host Anti-Tumor Response in Colorectal Cancer
- Chapter 15Adaptive and Innate Immunity, Non Clonal Players in Colorectal Cancer Progression
- Chapter 16The Role of Infectious Agents in Colorectal Carcinogenesis
- Chapter 17Streptococcus bovis/gallolyticus Induce the Development of Colorectal Cancer
- Chapter 18Intestinal Host-Microbiome Interactions
- Chapter 19Tumor Infiltrating Lymphocytes as Prognostic Factor of Early Recurrence and Poor Prognosis of Colorectal Cancer After Radical Surgical Treatment
- Chapter 20Fluorescent Biomarker in Colorectal Cancer
