About the book
The book will be an updated review on varicella zoster virus (VZV). It will include several sections covering various aspects of the virus. The virus genome, the various genotypes, epigenetic control, and the differences between VZV and other herpes viruses will be highlighted. Also, animal and experimental models of the virus will be discussed. The clinical manifestations and complications of VZV infections in immunocompromised individuals will be discussed thoroughly. However, VZV infection in patients with hematologic malignancies, bone marrow failure, and solid tumors in addition to recipients of various forms of hematopoietic stem cell transplantation will be given special attention. The diagnosis of VZV infections, treatment, vaccination and antiviral prophylaxis in this group of patients will be discussed in details. New literature on the pathogenesis of VZV infections including the cells involved, cellular proteins, extracellular vesicles, micro-RNAs, cytokines, interferons, and signaling pathways will be included. The emerging role of the virus in virotherapy, as well as the recently reported beneficial effects of the virus in immunocompromised hosts such as stimulation of bone marrow activity, antitumor effects, and associations with graft versus host disease, will receive particular attention due to the possible future implications of such discoveries in the treatment of immunocompromised patients.