Open access peer-reviewed Edited Volume

Multiple Organ Dysfunction Syndrome

Endre Zima

Semmelweis University


Enikő Kovács

Semmelweis University


Community Acquired Infection Nosocomial Infection Inflammation Systemic Immune Response Risk of Mortality Organ Injury Biomarkers Peripheral Hypoperfusion Early Antobiotic Therapy Acute Kidney Injury Fever Target Temperature Management Resuscitation

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About the book

This book aims to provide an up-to-date overview of the historic perspective on the specific diagnostic and therapeutic aspects of multiple organ failure (MOF) patient population treated in intensive care units. Sepsis with MOF is a life threatening syndrome with a high mortality rate (40-60%), that is based on clinical diagnosis. The epidemiology of multiple organ failure (MOF) is determined on the localisation patogene, and type of the first and the secondary patogenes. Pathomechanism of MOF may start from a banal inflammation, but systemic immune response syndrome and cytokine storm, vasodilation and hypoperfusion lead to the end-organ dysfunction and failure. Well-established old and novel comprehensive grading systems, biomakers urge the early aggressive therapeutic approach in the detected high risk patient population. Septic shock with peripherial hypoperfusion develops auto-augmented immunosuppression and indicates early antibiotic therapy and targeted shock resuscitation.

Publishing process

Book initiated and editor appointed

Date completed: August 26th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: November 15th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: February 3rd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: April 3rd 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Endre Zima

Semmelweis University

Dr. Zima works as the chief of Cardiac ICU at Semmelweis University Heart and Vascular Center. Dr. Zima is specialized in anesthesiology-intensive care and cardiology. Since 2006, he has been holding graduate and postraduate lectures and practices in anesthesiology and since 2008 in cardiology. He is a PhD Lecturer in Semmelweis University since 2010. He obtains an accreditation of EHRA on Cardiac Pacing and Implantable Cardioverter Defibrillators, he is accredited AALS Instructor of European Resuscitation Council. Dr. Zima authored 9 book chapters and more than 60 journal papers. He is a fellow of the European Heart Rhythm Association and Acute Cardiovascular Care Association, board member of the Hungarian Society of Cardiology, WG on Cardiac Pacing, WG of Heart Failure. Dr. Zima is also a member of the following societies: Hungarian Society of Resuscitation, Hungarian Society of Anesthesiology. His fields of interest are acute and intensive cardiac care, CPR and post-cardiac arrest intensive care, heart failure and cardiogenic shock, device therapy of arrhythmias, defibrillator waveform and AED development.

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