About the book
This book aims to provide an up-to-date overview of the historic perspective on the specific diagnostic and therapeutic aspects of multiple organ failure (MOF) patient population treated in intensive care units. Sepsis with MOF is a life threatening syndrome with a high mortality rate (40-60%), that is based on clinical diagnosis. The epidemiology of multiple organ failure (MOF) is determined on the localisation patogene, and type of the first and the secondary patogenes. Pathomechanism of MOF may start from a banal inflammation, but systemic immune response syndrome and cytokine storm, vasodilation and hypoperfusion lead to the end-organ dysfunction and failure. Well-established old and novel comprehensive grading systems, biomakers urge the early aggressive therapeutic approach in the detected high risk patient population. Septic shock with peripherial hypoperfusion develops auto-augmented immunosuppression and indicates early antibiotic therapy and targeted shock resuscitation.