About the book
The chromosome abnormalities account for the loss of a very high proportion of all human conceptions. About 15 to 20% of all recognized pregnancies end in spontaneous miscarriage and many more zygotes and embryos are so abnormal that survival beyond the first few days or weeks of pregnancy is not possible. Given that approximately 50% of all spontaneous miscarriages have a chromosome abnormality which may be either numerical or structural. The incidence of chromosome abnormalities at conception is likely at least as high as 20%. From conception onwards, the incidence of chromosome abnormalities falls rapidly. By birth, it has fallen to a level of 0.5-1%, although the total is much higher if only stillborn infants are considered. It is notable that amongst the commonly recognized aneuploidy syndromes there is also a high proportion of spontaneous pregnancy loss. Besides spontaneous abortion, chromosomal abnormalities result in leukemia and different types of syndromes and congenital anomalies.
This book will intend to provide the reader with a comprehensive overview of the current state of knowledge on chromosome abnormalities and their importance in the health and well-being of people.