Open access peer-reviewed Edited Volume

Chromosomal Abnormalities

Subrata Dey

West Bengal University of Technology

A distinguished researcher in human genetics and radiation biology, appointed as Vice-Chancellor of Swami Vivekananda University, India. He has published more than 80 research papers in refereed journals, edited five books on Down syndrome, and has completed eleven research projects funded by the Government Of India. Prof. Dey received a Golden Jubilee Award for excellence in teaching and research.


Chromosome Aberrations Karyotype Trisomy 21 Microdeletion Syndrome Polyploidy Aneuploidy Amniocentesis PCR of Maternal Blood Diagnosis Hermaphroditism Pseudohermaphroditism Chromatid Breaks and Gaps UV Light

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About the book

The chromosome abnormalities account for the loss of a very high proportion of all human conceptions. About 15 to 20% of all recognized pregnancies end in spontaneous miscarriage and many more zygotes and embryos are so abnormal that survival beyond the first few days or weeks of pregnancy is not possible. Given that approximately 50% of all spontaneous miscarriages have a chromosome abnormality which may be either numerical or structural. The incidence of chromosome abnormalities at conception is likely at least as high as 20%. From conception onwards, the incidence of chromosome abnormalities falls rapidly. By birth, it has fallen to a level of 0.5-1%, although the total is much higher if only stillborn infants are considered. It is notable that amongst the commonly recognized aneuploidy syndromes there is also a high proportion of spontaneous pregnancy loss. Besides spontaneous abortion, chromosomal abnormalities result in leukemia and different types of syndromes and congenital anomalies.

This book will intend to provide the reader with a comprehensive overview of the current state of knowledge on chromosome abnormalities and their importance in the health and well-being of people.

Publishing process

Book initiated and editor appointed

Date completed: April 16th 2021

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Deadline for chapter proposals: May 14th 2021

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Deadline for full chapters: July 13th 2021

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Review results due: October 1st 2021

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Expected publication date: November 30th 2021

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About the editor

Subrata Dey

West Bengal University of Technology

Prof. Subrata Dey received his Ph.D. degree from the University of Kalyani, India. He joined the faculty of Maulana Abul Kalam Azad University of Technology (formerly known as West Bengal University of Technology) as Professor of Biotechnology in 2005. His laboratory has long been involved in research on the molecular genetics of Down syndrome and other congenital disorders, the genetics of Alzheimer’s disease, the genetics of congenital heart disease, radiation-induced genomic instability, radioprotection and stem cell biology. Prof. Dey received a Golden Jubilee Award for excellence in teaching and research. He has published more than 80 research papers in referred journals, edited five books on Down syndrome and has completed eleven research projects funded by the Government Of India. Several students also received their Ph.D. under his supervision. Along with teaching and research, Prof. Dey has handled a number of administrative assignments successfully and made dedicated and innovative approaches with great integrity. Major administrative roles were Director of School of Biotechnology and Biological Sciences, Founder Co-ordinator of Centre for Genetic Studies, Member-Coordinator of Ekta Incubation Centre, Pro-Vice Chancellor and Vice-Chancellor of Maulana Abul Kalam Azad University of Technology, Vice Chancellor of Brainware University. Recently he joined as Vice Chancellor of Swami Vivekananda University, West Bengal, India.

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