Open access peer-reviewed Edited Volume

Gender-related Differences in Health and Disease

Zsuzsanna Suba

National Institute of Oncology


Genetic Alterations Ageing Central Obesity Insulin Resistance Coronary Heart Diseases Menopause Anovulatory Disorders Male Infertility Dementia Genetic Factors

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About the book

There are important biological and behavioral differences between the two genders. These differences strongly affect the epidemiology and pathophysiology of many widespread diseases. The level of sex steroids construes the main physiologic difference between men and women. Estrogen predominance seems to be a health advantage for premenopausal women as compared with men, which may be attributed to their higher estrogen production and an increased transactivation of their estrogen receptors (ERs). In contrast, after menopause with a cessation of ovarian hormone production, women lose their health advantage and they are similarly vulnerable to chronic diseases like men. The paradoxical effects of ovarian hormones on both the promotion and prevention of breast cancer have been debated for over 80 year’s practices of menopausal hormone therapy (MHT). However, the risks and benefits of MHT use may be reconsidered in the light of applied hormone formulas. All toxic complications of synthetic estrogen use and the ambiguous correlations with cancer risk may be explained via understanding the deregulation of ER activation by synthetic estrogens. In contrast, endogenous estrogens are the chief regulators of the genomic machinery in both men and women driving all physiologic functions in healthy cells, whilst inducing apoptotic death in cancer cells.

This book will be a self-contained collection of scholarly papers targeting an audience of practicing researchers, academics, PhD students and other scientists. The contents of the book will be written by multiple authors and edited by experts in the field.

Publishing process

Book initiated and editor appointed

Date completed: October 15th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: January 4th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 24th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 23rd 2020

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About the editor

Zsuzsanna Suba

National Institute of Oncology

Prof. Zsuzsanna Suba is an expert in clinical cancer genetics. She oversees an active research program that investigates the role of genetics in cancer risk and response to therapy. She gained both MD and Ph.D. degrees at the Semmelweis University in Budapest. Working in the 1st Institute of Pathology and Cancer Research, postdoctoral board certification in pathology was fulfilled. She worked in a cancer research team examining the effects of chemotherapeutic agents on in vitro cell cultures and experimental animals. Later, working in the Institute of Oral and Maxillofacial Surgery she gained the leadership of Oral Pathology Unit as a professor of oral pathology. She gained certification in oral pathology at the University of Sheffield. Her working group examined the metabolic and hormonal aspects of oral cancer including insulin resistance and estrogen deficiency as risk factors for cancer development. These investigations ensured successful graduations for her Ph.D. students. The next step was the examination of correlations between hormonal imbalance and genomic instability in men and women. In the National Institute of Oncology (Budapest), the genetic aspects of cancer risk and the possibilities of genomic stabilization in cancer therapy are investigated. Publications: articles: 132 (cumulated IF: 102.647), scientific and teaching books: 12 (4 in English), scientific and teaching book chapters: 43 (33 in English).

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