Open access peer-reviewed Edited Volume

Fungal Reproduction and Growth

Sadia Sultan

Universiti Teknologi MARA

Dr. Sadia Sultan is the Group Leader of the Biotransformation Group and a member of the American Chemical Society. For her research, she has been awarded several national grants as a principal investigator, including e-Science (Ministry of Science and Technology - MOSTI).


Gurmeet Kaur Surindar Singh

Universiti Teknologi MARA


Fungal Reproduction Fungal Growth Psyclotolerant Fungi Epigenetic Modifier Gene Expression Phenotype State Exogenous Substrate Microbial Transformation Elicitor Volatile Compound Cell End Marker Polarisome

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About the book

Fungi require a lot of organic nutrients for their biochemical processes. Manipulating the culture media can make significant changes in an organism's chemical composition. By using OSMAC (One Strain, Many Compounds) approach, various research groups were able to isolate additional secondary metabolites from a single strain by modifying the culturing media. Modifications of some parameters in culturing conditions such as pH, temperature, and light exposure can also diversify the fungi’s secondary metabolites. The temperature and pH of the broth can affect the activation or deactivation of the fungi’s enzyme involved in secondary metabolites production. Furthermore, light exposure, including the intensity and wavelength, is able to affect photoreceptors in some fungal species. For example, the production of mycophenolic acid by Penicillium brevicompactum can be stimulated by red or blue lights.

Epigenetics is a study of heritable changes in gene expression that occur without changes in DNA sequences. It refers to typically heritable biological mechanisms which facilitate stable yet reversible modifications of gene expression or phenotype state, without alteration of the underlying genetic code. In detail, epigenetic mechanisms allow organisms to control which genes are active at a given time. In eukaryotes, epigenetic mechanisms have essential roles in gene regulation, cellular differentiation, and genetic packaging. These epigenetic mechanisms give rise to functionality which DNA alone is generally incapable of providing. The regulation of enzymes that control secondary metabolites production can be achieved by modifying epigenetic mechanisms such as DNA methylation and histone modifications. Epigenetic modification can be inhibited by histone deacetylase (HDAC) and DNA methyltransferase inhibitors.All of these discoveries show that epigenome manipulation is a promising method to access the silent biosynthetic pathway in fungi that can stimulate the production of new secondary metabolites.

This book intends to provide a comprehensive overview of the effects of different parameters like epigenetic modifiers, volatile compound, etc. on fungal growth and reproduction from various biotopes.

Publishing process

Book initiated and editor appointed

Date completed: April 28th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: May 26th 2021

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Deadline for full chapters: July 25th 2021

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: October 13th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

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Expected publication date: December 12th 2021

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About the editor

Sadia Sultan

Universiti Teknologi MARA

Dr. Sadia Sultan is an Associate Professor of Pharmaceutical Chemistry at the Department of Pharmacology and Chemistry, Faculty of Pharmacy University Technology, MARA UiTM, Malaysia. She received her PhD Degree in 2004. Afterwards, she worked as a chemist in the QA department of Abbot Lab, Pakistan. In June 2006, she was appointed Lecturer in the Faculty of Pharmacy, UiTM Shah Alam and a fellow of Atta-ur-Rahman Institute for Natural Product Discovery (AuRIns). She has 15 years of experience in the field of Natural Product Research and her areas of expertise include biotransformation of exogenous substrates using microorganisms and plant tissue culture technique, exploring bioactive secondary metabolites from plant, soil and marine endophytic fungi (using Dereplication and OSMAC Approach), and biological screening using antimicrobial assays. She is the author of many e-books and chapters, and overall has more than 50 publications (h-index 16). For her research, she has been awarded several national grants as a principal investigator, including the e-Science grant (from Ministry of Science and Technology - MOSTI). Her research findings have also been recognized at several conferences, competitions and exhibitions, and awarded with several awards.

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