Open access peer-reviewed Edited Volume


Mani T. Valarmathi

The University of Alabama at Birmingham

Dr. Mani T. Valarmathi has had extensive experience in research on various types of stem cells. He is a member of Society for Stem Cell Research, American Association for Cancer Research, American Society for Investigative Pathology, American Chemical Society, European Society of Cardiology, American Society of Gene & Cell Therapy, American Heart Association.


Organoid Culture Organoid Protocols Stem Cell-derived Organoids Organoids Embryo Development Organoids Cancer Research Organoids and Disease Modeling Organoids in Personalized Medicine Organoids in Precision Medicine Organoids in Drug Development Organoids Biomarker Organoids-by-design Cryopreservation of Organoids

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About the book

Organoids are three-dimensional (3D) miniaturized self-organizing multicellular structures that are derived either from pluripotent and/or multipotent stem cells or from a tissue in culture. Organoid technology bridges the gap between conventional two-dimensional (2D) cell line culture and in vivo models, however, diverse drawbacks make these conventional models to be suboptimal. The near-physiological technology, organoid technology, enables us to investigate the early-stages of mammalian organogenesis in vitro, in the context of both physiological and pathological conditions. Besides, human organoid cultures provide the potential to explore human development and model disease processes. This novel human organoid model system allows us to study complex disease phenotypes and genetic variability among individuals using patient-derived stem cells and/or tissues. In recent years, there is substantial amount of advancement in the area of organoid biology, especially organoid generation, differentiation, and their cellular interactions, as well as in organoid engineering, for instance organoids-by-design and organoids-on-a-chip. In addition, since the advent of various emerging technologies, such as stem cell technology, genome editing technology, as well as developmental tissue engineering – stem cell-derived organoids are utilized more and more as a therapeutic tool not only in the area of tissue engineering and regenerative medicine but also in the areas of precision medicine, thus, the potentials, challenges, and limitations of human organoid research need to be addressed.

Therefore, the purpose of this book is to consolidate the recent advances in area of organoid biology/technology covering a broad-spectrum of interrelated topics in a timely fashion and to disseminate that knowledge in a comprehensible way to a greater scientific and clinical audience; topics of interest include but are not limited to the following:

• Organoids – Organoid Technology – Methods/Applications/Ethical Implications
• Organoids – Modeling Mammalian Development/Stem Cell Niche
• Organoids – Modeling of Mammalian Diseases (Cancer/Immunological/Genetic, etc.)
• Organoids – Genetic Engineering/Personalized Medicine
• Organoids – Drug Development/Toxicity Testing
• Organoids – Biomarkers/Therapeutic Agents
• Organoids – Biobanking/Cryopreservation
• Organoids – Tissue Engineering/Regenerative Medicine
• Organoids-By-Design/Organoids-On-A-Chip Technology

Publishing process

Book initiated and editor appointed

Date completed: July 2nd 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: September 21st 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: December 10th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: February 8th 2021

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Mani T. Valarmathi

The University of Alabama at Birmingham

Mani T. Valarmathi is presently an assistant professor at the University of Alabama at Birmingham, USA. He began his scientific career as a cancer geneticist, but soon became captivated with the emerging and translational fields of stem cell biology, tissue engineering, and regenerative medicine. After completing his Bachelor’s degree in Chemistry at the University of Madras, he received his MBBS in Medicine and Surgery and MD in Pathology from the University of Madras, as well as his PhD in Medical Biotechnology from All-India Institute of Medical Sciences, New Delhi, India. For over 15 years, he has had extensive experience in research on various types of stem cells, including adult, embryonic (pluripotent), and induced pluripotent stem cells. Currently, his research work focuses on generating three-dimensional vascularized tissues and/or organs for implantation purposes. He is a member of many prestigious national and international professional societies and scientific organizations, such as ISSCR, TERMIS, AACR, ASIP, ACS, ESC, ISHR, ASGCT, and AHA.

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Book chapters authored 2

Books edited 2

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