About the book
Biopharmaceutical therapeutics comprise of heterogeneous structurally complex drug molecules for potential therapy and diagnosis in diverse clinical settings such as infectious diseases, cancer, metabolic irregularities, and immunizations, etc. Structural complexity and heterogeneity of therapeutic modalities is often required for high specificity, potency, efficacy and safety. However, structural complexity and heterogeneity of these biopharmaceuticals is a major challenge to formulate and deliver intact to their extracellular and intracellular target sites. Biopharmaceuticals - Fabrication of Smart Architectures as Drug Cargoes hopes to highlight recent advances in formulation and delivery strategies from plain drug reformulation and modified release technologies to innovative platforms that hold enormous potential for the effective delivery of heterogeneous drugs. Technologies such as micro- and nanocargoes, stimuli-responsive systems, macromolecular conjugation and microfabricated systems have become more mainstream over recent years. In addition, surface engineered multifunctional polymeric carrier’s technology for diverse range of therapeutic modalities is precisely designed to improve penetration, absorption, and retention of drugs in hard-to-penetrate tissues. Other interesting carrier systems including lipid based vesicles, carbon nanostructures, metallic nanocarriers, immunotherapeutic agents, nucleic acid based structures and biomimics have shown enormous potential not only for targeted delivery of drug but also for diagnostic applications.