Open access peer-reviewed Edited Volume

Molecular and Metabolic Alterations in Tumorigenesis

Yasemin Basbinar

Dokuz Eylül University


Gizem Calibasi Kocal

Dokuz Eylül University


Tumorigenesis Gene mutations Tumor suppressor genes Metabolic enzymes Epigenetic modifications Metabolic reprogramming Cellular energy metabolism Mitochondria Metabolomics Aerobic glycolysis Mitochondrial oxidative phosphorylation Metabolic pathways

Register your interest in contributing to this book

Collaborate with our community and contribute your knowledge.

Register here

Deadline Extended: Open for Submissions

About the book

Tumorigenesis, the transformation of normal cells into cancer cells, is dependent on the change of primary DNA sequence with the effect of oncogenic mutations, gene fusions and amplifications. Apart from multiple genomic alterations, epigenetic changes such as amino acid modifications in histones and changes in the methylation of cytosine bases are also common in cancer. During continuous proliferation, cancer cells must sustain their energy source and metabolite pools for building macromolecules, which are needed for continuous proliferation. These requirements are accomplished in most cancer cells as an adaptation mechanism of a survival advantage or a consequence of continuous tumor growth The mechanisms behind the reprogramming of cellular metabolism, also include multiple genetic alterations in oncogenes and tumor suppressor genes, epigenetic modifications and mutations in metabolic enzymes. The molecular and metabolic profiles of cancer cells, which are crucial for their unlimited proliferation and survival, are also important to distinguish them from normal cells.

Publishing process

Book initiated and editor appointed

Date completed: September 23rd 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 13th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 2nd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 1st 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Yasemin Basbinar

Dokuz Eylül University

Dr.Yasemin Basbinar is a professor at the Department of Translational Oncology, Dokuz Eylul University, Institute of Oncology in Turkey. She graduated from Faculty of Medicine, Ege University, Turkey in 1988. She completed her PhD degrees in Biochemistry as well as Basic Oncology at Dokuz Eylul University, Turkey in 1995 and 2006, respectively. She worked in Danish Centre for Human Genome Research as a visiting researcher. She is, now the head of Personalized Medicine and Pharmacogenomics/Genomics Center and Department of Translational Oncology in Dokuz Eylul University. Her primary research focused on cancer pharmacogenomics and proteomics in terms of predictive medicine. She has been awarded by The Scientific and Technological Research Council of Turkey (TUBITAK), Turkish Association for Cancer Research and Control for her achievements. She has more than 70 publications in prestigious journals. She is on review boards of several journals and granting commitees.

View profile

Book chapters authored 1

Books edited 1

Introducing your Author Service Manager

Ms. Rozmari Marijan

As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

Ask a question

Book will be abstracted and indexed in