About the book
Tumorigenesis, the transformation of normal cells into cancer cells, is dependent on the change of primary DNA sequence with the effect of oncogenic mutations, gene fusions and amplifications. Apart from multiple genomic alterations, epigenetic changes such as amino acid modifications in histones and changes in the methylation of cytosine bases are also common in cancer. During continuous proliferation, cancer cells must sustain their energy source and metabolite pools for building macromolecules, which are needed for continuous proliferation. These requirements are accomplished in most cancer cells as an adaptation mechanism of a survival advantage or a consequence of continuous tumor growth The mechanisms behind the reprogramming of cellular metabolism, also include multiple genetic alterations in oncogenes and tumor suppressor genes, epigenetic modifications and mutations in metabolic enzymes. The molecular and metabolic profiles of cancer cells, which are crucial for their unlimited proliferation and survival, are also important to distinguish them from normal cells.