Open access peer-reviewed Edited Volume

Neural Regeneration

Denis Larrivee

Loyola University Chicago


Neurotoxicity and Inflammation Glymphatic System SNARE Activated Synaptogenesis mTOR Regenerative Activation Photobiomodulation Deep Brain Stimulation Tissue Engineered Nerve Implants Astrocyte Microspheres Magnetic Swarm Particles Smart Scaffolds Semaphorin Pluripotent Stem Cells

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About the book

Traumatic injury to the central nervous system is a major health issue affecting patients and families alike, with injuries to brain and spinal cord amounting to 1.5 million and 265,000 new cases each year respectively. To date, therapeutic interventions are limited to nerve grafting alone. A swelling number of key discoveries, however, now offer insight into specific cellular processes occurring during the initial degenerative phase and identifying multiple others that can then be activated during nerve and axonal regeneration. Spanning the range from neurotoxic gliosis to cue directed cell signaling and synaptogenesis this new knowledge is driving the development of allied technologies capable of responding to such cellular mechanisms and stimulating nerve recovery. Smart scaffolds, for example, marry advances in materials science with nanotechnology biosensors to create matrices that guide and activate neurite outgrowth; in other cases, conditioning electrical stimulation is used to initiate growth cone emergence while quantum dots deliver genetic cargo via maneuverable magnetic particles. Despite the significant progress in nerve regeneration, brain trauma remains, on the other hand, a broad frontier in early stages of exploration. Effective strategies here will likely involve non-invasive stimulation and pluripotent stem cell neurogenesis synchronized with multimodal approaches that match the complexity of the brain's neural connectivity, only now underway. This book will cover recent advances in the multifaceted domain of central nervous system regeneration and its alliance with an increasingly sophisticated and tailored biomedical arsenal.

Publishing process

Book initiated and editor appointed

Date completed: October 1st 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 21st 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 10th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 9th 2020

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About the editor

Denis Larrivee

Loyola University Chicago

Dr. Denis Larrivee is a Visiting Scholar at the Mind and Brain Institute, University of Navarra Medical School and Loyola University Chicago and has held professorships at the Weill Cornell University Medical College, NYC, and Purdue University, Indiana. A former fellow at Yale University's Medical School he received the Association for Research in Vision and Ophthalmology's first place award for studies on photoreceptor degenerative and developmental mechanisms. He is the editor of a recently released text on Brain Computer Interfacing with InTech Publishing and an editorial board member of the journals Annals of Neurology and Neurological Sciences (USA) and EC Neurology (UK). An International Neuroethics Society Expert he is the author of more than 80 papers and book chapters in such varied journals/venues as Neurology and Neurological Sciences (USA), Journal of Neuroscience, Journal of Religion and Mental Health, and IEEE Explore. In 2018 he was a finalist in the international Joseph Ratzinger Expanded Reason award.

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Book chapters authored 4

Books edited 3

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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