Open access peer-reviewed Edited Volume

P-glycoprotein, the Final Frontier

Alina Crenguţa Nicolae

Carol Davila University of Medicine and Pharmacy



Carol Davila University of Medicine and Pharmacy

Ion Bogdan Dumitrescu

Carol Davila University of Medicine and Pharmacy


Efflux Pump Transport ATP-Binding Cassette Drug Resistance Alzheimer's Disease Parkinson's Disease Permeability Drug Retention Oral Bioavailability Xenobiotics Neuroblastoma Cell Line Blood Brain Barrier

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About the book

The effectiveness of central nervous system pharmacotherapy is a major scientific challenge for the third millennium, being considered and called as "the final frontier of pharmacotherapy." This is mainly due to the inability of many drugs to cross the blood-brain barrier (BBB) and to reach concentrations that are sufficiently high in certain target areas of the brain. This barrier is at the level of microvascular cerebral capillary endothelium, and a defining characteristic of the cerebral capillary phenotype is the ATP-dependent expression of ATP-binding cassettes (ABC transporters) found on the endothelial cell luminal plasma membrane. These transporters restrict the absorption of lipophilic xenobiotics which, based on the structure, should easily diffuse through endothelial cell membranes. The most studied in terms of action and regulation mechanisms, is P-glycoprotein (P-gp) which modulates the transport of a very large number of therapeutic substances (it is expressed predominantly in cerebral capillary endothelium).
This book intends to provide the reader with a comprehensive overview of the scientific mechanisms that enhance the multidrug resistance impressed by the activity of the P-gp at the hematoencephalic barrier level: the cerebral oxidative status and the dynamics of the main neurotransmitters.

Publishing process

Book initiated and editor appointed

Date completed: August 7th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: October 27th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: January 15th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: March 15th 2020

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About the editor

Alina Crenguţa Nicolae

Carol Davila University of Medicine and Pharmacy

ALINA CRENGUȚA NICOLAE is currently an associate professor at the Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania. She is managing editor of FARMACIA journal, a major scientific publication gathering important research papers from the pharmaceutical field. In 2013, she completed her doctoral thesis 'Biochemical mechanisms involved in multidrug resistance', and the interest in investigating multidrug resistance has remained a central pillar of her activity. She is passionate about the field of neuropharmacology. Her research projects (conducted so far) focus on the individual neuro-biochemical profile, correlated with age, gender, race, metabolic and genetic profiles, as well as the establishment of predictive biomarkers that trigger the response to pharmacotherapy and multidrug resistance mechanisms modulation, at the level of blood-brain barrier. Mrs. Nicolae's scientific research is supported by many articles published in ISI journals, books and book chapters, among which 'P-glycoprotein and the development of multidrug resistance' represents a complete book revealing all the biochemical mechanisms underlying this vast and intricate process of multidrug resistence that occurs in living cells.

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