About the book
Pharmacogenetics is the effect of one gene variation on a single drug response while Pharmacogenomics is the effect of the genome (all the genes) on drug responses. Although the field of pharmacogenetics was established in the 1950s, clinical testing for constitutional pharmacogenetic variants implicated in interindividual drug response variability has only recently become available to help clinicians guide pharmacotherapy. In recent years, the convergence of advances in pharmacogenetics with rapid developments in human genomics has resulted in the evolution of pharmacogenetics into pharmacogenomics and led to increasing enthusiasm for the 'translation' of this evolving discipline into clinical practice. On the other hand, the developments of the nanotechnology field generated new potentials of therapeutic nanocarriers in the field of personalized medicine. Although the nanomaterials are of the same dimensions as many cellular types of machinery, their interaction with cells, tissues, and organs of the body are not well understood. This in turn forms the rationale for a comprehensive study of these nanoplatforms in various disease models in terms of their toxicity, pharmacokinetics, pharmacodynamics, and pharmacogenetics. Such a study will significantly aid in our quest in translating its application from bench to bedside.