Open access peer-reviewed Edited Volume

Bioreactors for Tissue Engineering and Regenerative Medicine

Dan Simionescu

Clemson University

Dr. Dan Simionescu is the Harriet and Jerry Dempsey Professor of Bioengineering and Director of the Biocompatibility and Tissue Regeneration Laboratories at the Clemson University, Clemson, SC, he has published more than 95 peer-reviewed papers.


Agneta Simionescu

Clemson University

Dr. Agneta Simionescu published and presented multiple peer-reviewed papers and patents in the field of cardiovascular engineering (HI=16) and received several presentation awards, in addition, she has built a variety of bioreactors for a heart valve, myocardial and vascular studies in her lab.

Leslie Sierad

Aptus LLC

Dr. Leslie Sierad is the Founder and President of Aptus Bioreactors whos goal is to provide sophisticated cardiovascular bioreactor systems to researchers all around the world, to date, the company has leased or sold 26 cardiovascular bioreactor systems to 8 different research groups on 3 continents.


Perfusion Bioreactors Devices Cardiovascular Engineering Bioreactors Pulsatility Orthopedic/Musculoskeletal Engineering Compression Nutrient and Gas Exchange Sterilization Safety Assembly Data Collection Parameter Control

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About the book

Bioreactors have become an integral part of tissue engineering and regenerative medicine enterprise. In the traditional paradigm of tissue engineering, cells are added to scaffolds by seeding and then the living constructs need to be maintained in physiologic conditions of temperature, flow of nutrients and gases, and mechanical or electrical stimuli typical of the target tissues. In many instances, the living constructs need to be exposed to additional specific stimuli for adaptation and maturation. Depending on the intended application, constructs will be kept alive for extended periods to serve as in vivo testing platforms, or prepared for implantation by in vitro conditioning. During this phase, cell phenotypes need to be maintained quiescent, under ideal perfusion conditions, with manual or automatic control over all parameters. To achieve these requirements, we need to design modular systems capable of exposing the constructs to stimuli in a measurable and controllable manner. This requires specific expertise in CAD, 3D printing, sterilization, parameter controls, instrumentation, software, hardware, pneumatics, biomechanics and cell biology, among others.

This book intends to provide the reader with an overview of the requirements for bioreactor design and implementation as well as specific applications for tissue engineering and regenerative medicine.

Publishing process

Book initiated and editor appointed

Date completed: September 18th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: December 15th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 5th 2021

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 4th 2021

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About the editor

Dan Simionescu

Clemson University

Dr. Dan Simionescu is the Harriet and Jerry Dempsey Professor of Bioengineering and Director of the Biocompatibility and Tissue Regeneration Laboratories at the Clemson University, Clemson, SC. He has published more than 95 peer-reviewed papers in highly ranked journals such as Circulation, Cardiovascular Pathology, American Journal of Pathology, Tissue Engineering, and Biomaterials and has more than 180 peer-reviewed conference proceedings presented worldwide. Dr. Simionescu’s general research interests include cardiovascular biology, pathology, and regeneration using scaffolds, stem cells and bioreactors. His current interest is preclinical validation of translational tissue engineering approaches and is being generously funded by the NIH and the biomedical industry for his efforts in the field of cardiovascular biology, pathology, and regenerative medicine.

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