Open access peer-reviewed Edited Volume

Extracellular Matrix

Rama Sashank Madhurapantula

Illinois Institute of Technology

Most recently, dr. Madhurapantula has been involved with developing microscopy techniques to establish macroscopic stress vs. strain relations in body tissues that present mixed tissue compositions, in conjunction with X-ray diffraction scanning techniques to establish tissue composition.


Collagen Proteoglycans Arthritis Congenital Diseases Osteogenesis Imperfecta Blood Vessels ECM - Tissue Interfaces Elasticity Cartilage Implant Bone Graft Angiogenesis Extracellular Triggers

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About the book

The Extra Cellular Matrix (ECM) connects cells in tissues and provides the organization and support for every organ system of the body. To fully understand physiology, it is important to study cellular biology in the context of its communication with its surrounding environment, a large part of which is the ECM. The ECM is a complex system in mammals which is responsible, not just for structural support, but function. Specific amino acid sequences on ECM elements elicit intra and extracellular biochemical cascades leading to cell division, proliferation, wound healing and inflammation. ECM interactions with transmembrane receptors may induce, accelerate, retard and/or halt intra-cellular processes. There has been a significant increase in the number of people suffering from ECM-related maladies, creating the need for us to understand these diseases at a molecular level, to design novel, smart therapeutic regimens. The development of ECM implants is steadily increasing, with overwhelming market demand.

The aim of this book is to report on the latest developments in the molecular structure-function relationships of various ECM elements. The book will also focus on the latest reports of the role of ECM in various physiological and pathological conditions, and the developments in medical and surgical intervention through tissue engineering (implants).

Publishing process

Book initiated and editor appointed

Date completed: July 3rd 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: September 22nd 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: December 11th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: February 9th 2021

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About the editor

Rama Sashank Madhurapantula

Illinois Institute of Technology

Dr. Madhurapantula holds a Ph.D. in Biology from the Illinois Institute of Technology, Chicago, with a focus on the molecular structure and function of type I collagen. Since obtaining his Ph.D., he has worked on various ECM based research projects on understanding the structural aspects of various fibrous tissue assemblies in the human body, in non-disease and disease conditions. He is an expert in the field of in situ X-ray fiber diffraction. Most recently, he has been involved with developing microscopy techniques to establish macroscopic stress vs. strain relations in body tissues that present mixed tissue compositions, in conjunction with X-ray diffraction scanning techniques to establish tissue composition. These datasets together are being used to develop a high definition model of human heart valves with accurate stress-strain finite element models to improve the characteristics of these tissues in the CAVEMAN full human body simulation, which is further utilized in simulated blast and vehicular accident calculations, and to develop a simulated surgery apparatus to train surgeons.

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