Open access peer-reviewed Edited Volume

Graves' Disease

Robert Gensure

Tufts Medical Center

A physician-scientist with significant experience in basic science and clinical research in pediatric endocrinology, bone, and mineral metabolism, and with clinical experience serving as chief of pediatric endocrinology at Tufts Medical Center.

Covering

Autoimmune Disorders Thyroid-stimulating Immunoglobulin Toxic Diffuse Goiter Hashitoxicosis Methimazole Beta-blockers Iodine Rates of Remission Rates of Relapse Radioactive Iodine Activation and Flair with Pregnancy Medical Therapy and Birth Defects Remission Rates

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About the book

Graves' disease was first described in 1835, taking its name from the physician who identified it, Dr. Robert Graves. Mainstays of treatment have included antithyroid medication and surgical removal of the thyroid gland. More recent advances in both diagnostic and treatment modalities have led to alterations in clinical management of Graves disease. Much of this has been enabled by enhancements in our understanding of the pathology of the disorder. Enhanced understanding of the natural course of the disease, including patterns of remission and relapse, have reduced the need for more definitive therapy. There are also more options for definitive therapy, with radio ablation of the thyroid gland has increased in popularity over thyroidectomy. As with so many disorders, there are special considerations in pregnancy and with pediatric patients.

The purpose of this publication will be to review our current understanding of Graves disease and the evolving recommendations for the diagnosis and treatment of this disorder.

Publishing process

Book initiated and editor appointed

Date completed: September 11th 2020

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 9th 2020

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Deadline for full chapters: December 8th 2020

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Full chapters peer reviewed

Review results due: February 26th 2021

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Expected publication date: April 27th 2021

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About the editor

Robert Gensure

Tufts Medical Center

CURRICULUM VITAE ROBERT CHARLES GENSURE, M.D. 1. Date of Birth: November 19, 1966 2. Education and Postgraduate Training: 09/1984-05/1987 The Johns Hopkins University, Baltimore, Maryland BS 06/1987-08/1988 Associate Engineer, United Technologies Norden Systems, Norwalk, CT (work position) 09/1988-05/1993 Tulane University, New Orleans, Louisiana PhD 09/1988-06/1995 Tulane University School of Medicine, New Orleans, Louisiana MD 06/1993-06/1995 Research Fellow in Endocrine Physiology, Tulane University School of Medicine, New Orleans, Louisiana 07/1995-06/1998 Pediatric Resident, Massachusetts General Hospital, Boston, Massachusetts 07/1998-06/2001 Clinical Fellow in Pediatric Endocrinology, Massachusetts General Hospital, Boston, Massachusetts 07/1999-06/2001 Research Fellow in Medicine, Massachusetts General Hospital, Boston, Massachusetts 3. Professional Appointments: A. University 07/2001-11/2003 Instructor in Pediatrics, Harvard Medical School, Boston, Massachusetts. 07/2001-11/2003 Instructor in Medicine, Harvard Medical School, Boston, Massachusetts. 11/2003-04/2005 Assistant Professor of Pediatrics, Tulane University, School of Medicine, New Orleans, Louisiana. 04/2005-08/2010 Associate Professor in Pediatrics, Ochsner Clinic Foundation, New Orleans, Louisiana 08/2010-08/2011 Assistant Professor in Pediatrics, Albert Einstein College of Medicine, Bronx, NY 08/2011-12/2015 Associate Professor in Pediatrics, Albert Einstein College of Medicine, Bronx, NY B. Hospital 07/2001-11/2003 Assistant in Pediatrics, Massachusetts General Hospital, Boston, Massachusetts. 11/2003-04/2005 Section Chief of Pediatric Endocrinology, Tulane University, School of Medicine, New Orleans, Louisiana. 04/2005-08/2010 Section Chief of Pediatric Endocrinology, Ochsner Clinic Foundation, New Orleans, Louisiana. 08/2010-12/2015 Attending Physician, Pediatric Endocrinology, Children’s Hospital at Montefiore, Bronx, New York 01/2016-present Chief, Pediatric Endocrinology, Tufts Medical Center/Floating Hospital for Children, Boston, MA 4. Medical License: #258253(New York) Certification: American Board of Pediatrics 2001-2011 American Board of Pediatric Endocrinology 2003-2022 International Society for Clinical Densitometry 2011-2015 5. Professional Society Memberships: 1993 Endocrine Society 2002 American Society of Bone and Mineral Research 2008 American Society of Clinical Endocrinologists 2008 International Bone and Mineral Society 2008-2010 Southern Society for Pediatric Research 2009 International Society for Clinical Densitometry 2010 European Society for Dermatologic Research 2012 Society for Investigative Dermatology 2014 National Osteoporosis Foundation 6. Awards and Honors: 1990 McGraw-Hill Book Award, Tulane University School of Medicine 1990-1991 Louisiana Superior Student Stipend Award 1991 Travel Award, The Endocrine Society 1991-1993 Howard Hughes Medical Institute Predoctoral Fellowship 1995 DiLuzio Award in Physiology 2002 John Haddad Young Investigator Award 2004 American Society for Bone and Mineral Research Young Investigator Award 2006 Excellence in Research Award, Pediatrics, Ochsner Clinic Foundation 7. Other Professional Activities: National Committees, Advisory Groups, Study Sections, Consultantships 2001-Present Reviewer: New England Journal of Medicine 2003-Present Reviewer: Journal of Molecular Endocrinology 2008-Present Genentech Physician Advisory Board 2009-Present Chief Medical Officer, BiologicsMD, Fayetteville, AK 2012-Present Reviewer: GeneReview 2013-Present Reviewer: International Journal of Case Reports and Images 2014-Present Alexion Physican Advisory Board 2010-Present Reviewer, Clinical Pediatrics 2013-Present Editorial Board, Journal of Clinical and Translational Endocrinology 2015-Present Editorial Board , Journal of Pediatric Endocrinology 2015-Present Reviewer: Journal of Experimental Biology and Medicine 2017-Present Board Member, Advances in Mineral Metabolism 8. Patents: 20100129341 (Europe – EP2155874, world WO/2008/124166) Fusion proteins of collagen binding domain and parathyroid hormone (currently sublicensed to BiologicsMD, Fayetteville, AK) 2004017685 (world - WO/2002/068585) TIP39 polypeptides

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