About the book
The pineal hormone melatonin (N-acetyl-5-methoxytryptamine) modulates circadian rhythms and sleep-wake cycles, primarily via activation of the MT1 and MT2 melatonin receptors which exhibit distinct pharmacological profiles. Melatonin has a hypnotic action in animals and humans and there is considerable interest in its therapeutic action in sleep. It also has therapeutic potential in Seasonal Affective Disorders (SAD) and as an agent in restoring circadian rhythms in the blind and where these have been disturbed by shift-work or jet-lag. melatonin has also been implicated in Alzheimer's and other neurodegenerative disorders, in certain cancers, in Parkinson's disease and as an anti-oxidant. This book focuses on the chemistry of a wide range of melatoninergic analogues, their MT1 and MT2 agonistic and antagonistic action, and the controlled release profile of their pharmaceutical formulations, now available. The synthesis and pharmacology of indole and bioisosteric core molecules will be described first, conformationally constrained and chiral compounds second, and molecules with substituted C3-side chains third. An overview of controlled release formulations of melatonin and some analogues from these three classes is also presented.