Open access peer-reviewed Edited Volume

Melatonin

Marilena Vlachou

National and Kapodistrian University of Athens

Covering

Biosynthesis Pineal Gland Circadian Rhythms Melatonin Agonists and AntagoinistsTherapeutic Profile Melatoninergics Pharmaceutical Formulations of Melatonin Pharmaceutical Formulations of Synthetic Analogues Immediate release Modified Release MT1/MT2 Selectivity Clinical Uses

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About the book

The pineal hormone melatonin (N-acetyl-5-methoxytryptamine) modulates circadian rhythms and sleep-wake cycles, primarily via activation of the MT1 and MT2 melatonin receptors which exhibit distinct pharmacological profiles. Melatonin has a hypnotic action in animals and humans and there is considerable interest in its therapeutic action in sleep. It also has therapeutic potential in Seasonal Affective Disorders (SAD) and as an agent in restoring circadian rhythms in the blind and where these have been disturbed by shift-work or jet-lag. melatonin has also been implicated in Alzheimer's and other neurodegenerative disorders, in certain cancers, in Parkinson's disease and as an anti-oxidant. This book focuses on the chemistry of a wide range of melatoninergic analogues, their MT1 and MT2 agonistic and antagonistic action, and the controlled release profile of their pharmaceutical formulations, now available. The synthesis and pharmacology of indole and bioisosteric core molecules will be described first, conformationally constrained and chiral compounds second, and molecules with substituted C3-side chains third. An overview of controlled release formulations of melatonin and some analogues from these three classes is also presented.

Publishing process

Book initiated and editor appointed

Date completed: October 28th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline Extended: Open for Submissions

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

Approved chapters written in full and submitted

Deadline for full chapters: April 13th 2020

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: July 2nd 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: August 31st 2020

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About the editor

Marilena Vlachou

National and Kapodistrian University of Athens

Marilena Vlachou is an Assistant Professor at the National and Kapodistrian University of Athens (NKUoA), Greece. She obtained her Pharmacy and PhD (Pharmaceutical Technology) degrees from the NKUoA. Just prior to obtaining her PhD degree she moved to the University of Rhode Island, U.S.A., as a Visiting Research Scientist, to conduct state of the art research related to Pharmaceutical Technology techniques. In NKUoA, she teaches, at both undergraduate and postgraduate level, courses related to the fields of Pharmaceutical Technology, Physical Pharmacy and Nanotechnology. She has co-authored the textbook entitled “Pharmaceutical Technology I: Principles of Physical Pharmacy and Nanotechnology”, 2007, and the following book chapters: • “Melatonin modified release formulations” in C. M. Dragoi Ed. Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches (ISBN 978-953-51-6797-6, DOI: 10.5772/intechopen.78337 (2018)). • “Electrospinning and drug delivery” in Sajjad Haider and Adnan Haider Ed “Electrospinning and Electrospraying - Techniques and Applications”. ISBN 978-1-78984-700-0 DOI: 10.5772/intechopen.86181 (2019). • “Βiopolymers in drug delivery systems”, in C. Demetzos and N. Pippa Eds, “Nanomaterials for Clinical applications”. ISBN: 9780128167052, Εlsevier 2019. She has presented her research work in more than sixty (60) International and Domestic Scientific Conferences. She has published more than forty (40) articles in peer-reviewed Journals and is a member of the Greek Pharmaceutical Society, the Greek Society of Pharmaceutical Technology, and the Greek Section of the Society of Controlled Release of Drugs.

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Book chapters authored 2

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Introducing your Author Service Manager

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As an Author Service Manager my responsibilities include monitoring and facilitating all publishing activities for authors and editors. From chapter submission and review, to approval and revision, copyediting and design, until final publication, I work closely with authors and editors to ensure a simple and easy publishing process. I maintain constant and effective communication with authors, editors and reviewers, which allows for a level of personal support that enables contributors to fully commit and concentrate on the chapters they are writing, editing, or reviewing. I assist authors in the preparation of their full chapter submissions and track important deadlines and ensure they are met. I help to coordinate internal processes such as linguistic review, and monitor the technical aspects of the process. As an ASM I am also involved in the acquisition of editors. Whether that be identifying an exceptional author and proposing an editorship collaboration, or contacting researchers who would like the opportunity to work with IntechOpen, I establish and help manage author and editor acquisition and contact.

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