About the book
The presented book is devoted to one of the most prevalent spontaneous headache - a migraine. Chapters in the book will comprise of the most important contemporary topics in the field, including pathophysiology of the disease as a basis for migraine treatment, therapy of the disease - both abortive and prophylactic, and therapy of chronic migraine. One chapter on therapy will describe current therapeutic options, including monoclonal antibodies against both molecules of Calcitonin-Genene Related Peptide (CGRP), that plays crucial part in migraine pathophysiology and CGRP receptor as well. The separate chapter devoted to genetics of migraine will describe both monogenic and polygenic components in migraine inheritance. In another chapter, the genetic basis for one of the most established monogenic mutation - familial hemiplegic migraine, as well as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) or mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), will be considered. The neuroradiology part will discuss some techniques that have become widely used methods for measuring more accurately, due to a larger resolution, temporal and spatial image of the brain’s neural activity and its connectivity in migraine as the current development, and in the future. The chapter on chronic migraine will provide profound information on pathophysiology, clinical features and treatment options in this troublesome and unique form of migraine. The book will be indispensable publication for all doctors interested in spontaneous headaches.