Open access peer-reviewed Edited Volume

Chagas Disease - From Cellular and Molecular Aspects of Trypanosoma cruzi-Host Interactions to the Clinical Intervention

Rubem Menna-Barreto

Fundação Oswaldo Cruz

Dr. Menna-Barreto received his PhD in cellular and molecular biology from Fundação Oswaldo Cruz, Brazil. Full researcher in cell biology and protozoology, author of 118 articles in indexed international journals.


Chagas Disease Neglected Diseases Diagnosis T. cruzi Host Cell Oxidative Stress Mammalian Cell Triatomine Chemotherapy Biomarkers Vaccine High Throughput Screening

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About the book

Even after 110 years from Carlos Chagas´ discovery, Chagas disease still poses an important public health problem especially in Latin America, where it is endemic. The limited effect of the current treatment in the chronic phase of the disease, as well as the lacking information about the disease progression, are crucial challenges, justifying the intense efforts directed to this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species, vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features related to the parasite's success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines to be tested in preclinical and clinical trials in the future. In this book, the perspectives and limitations of the knowledge in Chagas disease and its etiological agent will be discussed, from the clinically relevant aspects (diagnosis, treatment, biomarkers, etc) to the frontier information about cellular, molecular and biochemical characteristics of the parasite-host interactions.

Publishing process

Book initiated and editor appointed

Date completed: October 6th 2021

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: November 3rd 2021

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Approved chapters written in full and submitted

Deadline for full chapters: January 2nd 2022

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 23rd 2022

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

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Expected publication date: May 22nd 2022

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About the editor

Rubem Menna-Barreto

Fundação Oswaldo Cruz

Formation: graduated in biology (USU, 1999-2003); PhD in cellular and molecular biology (FIOCRUZ, 2006-2008); posdoc in mitochondrial metabolism (UFRJ, 2009-2010). Professional position: Full researcher in Public Health, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, Brazil Research lines: (a) Autophagy and pathogenic protozoa; (b) Energetic and redox metabolism of trypanosomatids; (c) Proteomics of trypanosomatids; (d) Experimental chemotherapy for Chagas disease and leishmaniasis Editorial board: Frontiers in Medicine (review editor in Infectious Diseases – Surveillance, Prevention and Treatment, 2021 - up to now); Frontiers in Cellular and Infection Microbiology (Research Topic, 2021); Bio Collection (FIOCRUZ, 2020 - up to now) Publications: 118 articles in indexed international journals, 12 book chapters, and 3 editted books.

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Book chapters authored 2

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