About the book
Even after 110 years from Carlos Chagas´ discovery, Chagas disease still poses an important public health problem especially in Latin America, where it is endemic. The limited effect of the current treatment in the chronic phase of the disease, as well as the lacking information about the disease progression, are crucial challenges, justifying the intense efforts directed to this illness. The interaction between the etiological agent Trypanosoma cruzi and its invertebrate and vertebrate hosts involves the regulation of the parasite virulence and host immune responses. T. cruzi presents mechanisms to evade host defenses, including resistance to oxidative species, vesicles secretion, among many others. In this context, a better understanding of the biochemical and molecular features related to the parasite's success inside its hosts could contribute to the development of novel anti-T. cruzi strategies such as prototypes of drugs and vaccines to be tested in preclinical and clinical trials in the future. In this book, the perspectives and limitations of the knowledge in Chagas disease and its etiological agent will be discussed, from the clinically relevant aspects (diagnosis, treatment, biomarkers, etc) to the frontier information about cellular, molecular and biochemical characteristics of the parasite-host interactions.