Open access peer-reviewed Edited Volume

Lipoproteins and Apolipoproteins - New Perspectives and Applications

Miljana Jovandaric

Clinical Center of Serbia

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Pregnancy Asphyxia Ischaemia Blood Vessels Lipids Mortality Morbidity Obesity Free Radicals Oxidative Stress Athletes Training Length

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About the book

"Cholesterol, triglycerides, and high-density lipoproteins are important constituents of the lipid fraction of the human body. Cholesterol is an unsaturated alcohol of the steroid family of compounds. It is essential for the normal function of all animal cells and is a fundamental element of their cell membranes. It is also a precursor to various critical substances such as adrenal and gonadal steroid hormones and bile acids. Triglycerides are fatty acid esters of glycerol and represent the major lipid component of dietary fat and fat depots of animals.Cholesterol and triglycerides, being nonpolar lipid substances (insoluble in water), need to be transported in the plasma associated with various lipoprotein particles. Plasma lipoproteins are separated by hydrated density, electrophretic mobility, size and their relative content of cholesterol, triglycerides, and protein into five major classes: chylomicrons, very-low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins (LDL), and high-density lipoproteins ( HDL).

Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins. They transport lipids (and fat soluble vitamins) in blood, cerebrospinal fluid and lymph.The lipid components of lipoproteins are insoluble in water. However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating a lipoprotein particle that is itself water-soluble, and can thus be carried through water-based circulation.

In addition to stabilizing lipoprotein structure and solubilizing the lipid component, apolipoproteins interact with lipoprotein receptors and lipid transport proteins, thus participating in lipoprotein uptake and clearance. They also serve as enzyme cofactors for specific enzymes involved in the metabolism of lipoproteins.

Lipoprotein and apoliprotein concentrations change in different states. The study has implications for the prevention of diseases accompanying hypo or hyperliproteinemia with apolipoprotein concentration disorder"

Publishing process

Book initiated and editor appointed

Date completed: October 9th 2019

Applications to edit the book are assessed and a suitable editor is selected, at which point the process begins.

Chapter proposals submitted and reviewed

Deadline for chapter proposals: October 30th 2019

Potential authors submit chapter proposals ready for review by the academic editor and our publishing review team.

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Approved chapters written in full and submitted

Deadline for full chapters: December 29th 2019

Once approved by the academic editor and publishing review team, chapters are written and submitted according to pre-agreed parameters

Full chapters peer reviewed

Review results due: March 18th 2020

Full chapter manuscripts are screened for plagiarism and undergo a Main Editor Peer Review. Results are sent to authors within 30 days of submission, with suggestions for rounds of revisions.

Book compiled, published and promoted

Expected publication date: May 17th 2020

All chapters are copy-checked and typesetted before being published. IntechOpen regularly submits its books to major databases for evaluation and coverage, including the Clarivate Analytics Book Citation Index in the Web of ScienceTM Core Collection. Other discipline-specific databases are also targeted, such as Web of Science's BIOSIS Previews.

About the editor

Miljana Jovandaric

Clinical Center of Serbia

Dr. Miljana Jovandaric was born in Serbia in 1963. She graduated from the Faculty of Medicine - University of Belgrade. Dr. Jovandaric completed Specialist Examination in Pediatrics at the University Children's Hospital, Belgrade. Her narrow specialization in neonatology work is "Comparative Analysis of Newborns of Mothers Suffering from Gestational Diabetes and Pregestational Mellitus". She completed her MSc in neonatology ("Analysis of Lipid Infants of Women Suffering from Gestational Diabetes Mellitus (GDM)"), and defended her doctoral dissertation ("Effect of Hypoxia on Electrolyte and Lipid Levels in Term Newborns"), at the School of Medicine, University of Belgrade, Serbia. Dr. Jovandaric authored and co-authored 74 scientific papers, which were presented at both national and international conferences, and in journals. Currently, she is Head of the Department of Newborns, Clinic of Gynecology and Obstetrics, Department of Neonatology, Clinical Center of Serbia, Belgrade. Dr. Jovandaric acts as a member of numerous editorial boards and as a reviewer for a large number of journals. Her research interest include neonatology, metabolism, and perinatology.

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